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Conserved domains on  [gi|1034640891|ref|XP_016864013|]
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relaxin receptor 1 isoform X9 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
126-336 2.67e-26

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 108.48  E-value: 2.67e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640891 126 SNVTAMSLQWNLIRKLPPDcFKNYHDLQKLYLQNNKITSISIyAFRGLNSLTKLYLSHNRITFLkPGVFEDLHRLEWLII 205
Cdd:COG4886   113 TNLESLDLSGNQLTDLPEE-LANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDL 189

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640891 206 EDNHLSRIsPPTFYGLNSLILLVLMNNVLTRLPDkPLcQHMPRLHWLVMRKNKINHLNEntFAPLQKLDELDLGSNKIEN 285
Cdd:COG4886   190 SNNQITDL-PEPLGNLTNLEELDLSGNQLTDLPE-PL-ANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTD 264

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1034640891 286 LPPLifKDLKELSQLNLSYNPIQKIQANQFDYLVKLKSLSLEGIEISNIQQ 336
Cdd:COG4886   265 LPPL--ANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLEL 313
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 27-62 2.86e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 51.82  E-value: 2.86e-09
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1034640891  27 CSLGYFPCGNiTKCLPQLLHCNGVDDCGNQADEDNC 62
Cdd:cd00112     1 CPPNEFRCAN-GRCIPSSWVCDGEDDCGDGSDEENC 35
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
126-336 2.67e-26

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 108.48  E-value: 2.67e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640891 126 SNVTAMSLQWNLIRKLPPDcFKNYHDLQKLYLQNNKITSISIyAFRGLNSLTKLYLSHNRITFLkPGVFEDLHRLEWLII 205
Cdd:COG4886   113 TNLESLDLSGNQLTDLPEE-LANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDL 189

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640891 206 EDNHLSRIsPPTFYGLNSLILLVLMNNVLTRLPDkPLcQHMPRLHWLVMRKNKINHLNEntFAPLQKLDELDLGSNKIEN 285
Cdd:COG4886   190 SNNQITDL-PEPLGNLTNLEELDLSGNQLTDLPE-PL-ANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTD 264

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1034640891 286 LPPLifKDLKELSQLNLSYNPIQKIQANQFDYLVKLKSLSLEGIEISNIQQ 336
Cdd:COG4886   265 LPPL--ANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLEL 313
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 111-348 3.10e-15

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 73.67  E-value: 3.10e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640891 111 LDCDETNLRAVPSVSS--NVTAMSLQWNLIRKLPP-DCFKNyhdLQKLYLQNNKITSISiyAFRGLNSLTKLYLSHNRIT 187
Cdd:cd21340     7 LYLNDKNITKIDNLSLckNLKVLYLYDNKITKIENlEFLTN---LTHLYLQNNQIEKIE--NLENLVNLKKLYLGGNRIS 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640891 188 FLKpGvFEDLHRLEWLIIEDNHLSRISPPTFyGLNSLILLVlmnnvltrlpdkplcqhmPRLHWLVMRKNKINHLNEntF 267
Cdd:cd21340    82 VVE-G-LENLTNLEELHIENQRLPPGEKLTF-DPRSLAALS------------------NSLRVLNISGNNIDSLEP--L 138

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640891 268 APLQKLDELDLGSNKIENLPPL--IFKDLKELSQLNLSYNPIQKiQANQFDYLVkLKSLSLE---GIEISNiQQRMFrpL 342
Cdd:cd21340   139 APLRNLEQLDASNNQISDLEELldLLSSWPSLRELDLTGNPVCK-KPKYRDKII-LASKSLEvldGKEITD-TERQF--L 213


                  ....*.
gi 1034640891 343 MNLSHM 348
Cdd:cd21340   214 KRLKAR 219
LRR_8 pfam13855
Leucine rich repeat;
152-210 1.43e-14

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 67.55  E-value: 1.43e-14
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1034640891 152 LQKLYLQNNKITSISIYAFRGLNSLTKLYLSHNRITFLKPGVFEDLHRLEWLIIEDNHL 210
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 27-62 2.86e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 51.82  E-value: 2.86e-09
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1034640891  27 CSLGYFPCGNiTKCLPQLLHCNGVDDCGNQADEDNC 62
Cdd:cd00112     1 CPPNEFRCAN-GRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 26-59 6.89e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 48.01  E-value: 6.89e-08
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1034640891   26 KCSLGYFPCGNiTKCLPQLLHCNGVDDCGNQADE 59
Cdd:smart00192   1 TCPPGEFQCDN-GRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
25-62 1.99e-06

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 43.78  E-value: 1.99e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1034640891  25 VKCSLGYFPCGNiTKCLPQLLHCNGVDDCGNQADEDNC 62
Cdd:pfam00057   1 STCSPNEFQCGS-GECIPRSWVCDGDPDCGDGSDEENC 37
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 176-326 4.21e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 48.69  E-value: 4.21e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640891 176 LTKLYLSHNRITFLKPGVFEDLHRLEWLIIEDNHLSRISPPTFYGLNSLILLVLMNNVLT-RLPDKPLcqHMPRLHWLVM 254
Cdd:PLN00113  382 LFKLILFSNSLEGEIPKSLGACRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQgRINSRKW--DMPSLQMLSL 459

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1034640891 255 RKNKINHLNENTFAPlQKLDELDLGSNKIENLPPLIFKDLKELSQLNLSYNPIQKIQANQFDYLVKLKSLSL 326
Cdd:PLN00113  460 ARNKFFGGLPDSFGS-KRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDL 530
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
126-336 2.67e-26

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 108.48  E-value: 2.67e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640891 126 SNVTAMSLQWNLIRKLPPDcFKNYHDLQKLYLQNNKITSISIyAFRGLNSLTKLYLSHNRITFLkPGVFEDLHRLEWLII 205
Cdd:COG4886   113 TNLESLDLSGNQLTDLPEE-LANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDL 189

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640891 206 EDNHLSRIsPPTFYGLNSLILLVLMNNVLTRLPDkPLcQHMPRLHWLVMRKNKINHLNEntFAPLQKLDELDLGSNKIEN 285
Cdd:COG4886   190 SNNQITDL-PEPLGNLTNLEELDLSGNQLTDLPE-PL-ANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTD 264

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1034640891 286 LPPLifKDLKELSQLNLSYNPIQKIQANQFDYLVKLKSLSLEGIEISNIQQ 336
Cdd:COG4886   265 LPPL--ANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLEL 313
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
146-335 2.82e-23

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 100.01  E-value: 2.82e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640891 146 FKNYHDLQKLYLQNNKITSISIyAFRGLNSLTKLYLSHNRITFLkPGVFEDLHRLEWLIIEDNHLSRIsPPTFYGLNSLI 225
Cdd:COG4886   109 LSNLTNLESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLK 185

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640891 226 LLVLMNNVLTRLPDkPLCQhMPRLHWLVMRKNKINHLNENtFAPLQKLDELDLGSNKIENLPPLifKDLKELSQLNLSYN 305
Cdd:COG4886   186 ELDLSNNQITDLPE-PLGN-LTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNNQLTDLPEL--GNLTNLEELDLSNN 260

                         170       180       190
                  ....*....|....*....|....*....|
gi 1034640891 306 PIQKIqaNQFDYLVKLKSLSLEGIEISNIQ 335
Cdd:COG4886   261 QLTDL--PPLANLTNLKTLDLSNNQLTDLK 288
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
157-334 2.96e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 76.51  E-value: 2.96e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640891 157 LQNNKITSISIYAFRGLNSLTKLYLSHNRItflkpgvFEDLHRLEWLIIEDNHLSRIsPPTFYGLNSLILLVLMNNVLTR 236
Cdd:COG4886    79 LLLLSLLLLGLTDLGDLTNLTELDLSGNEE-------LSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTD 150

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640891 237 LPDKplCQHMPRLHWLVMRKNKINHLNENtFAPLQKLDELDLGSNKIENLPPLIFKdLKELSQLNLSYNPIQKIqANQFD 316
Cdd:COG4886   151 LPEP--LGNLTNLKSLDLSNNQLTDLPEE-LGNLTNLKELDLSNNQITDLPEPLGN-LTNLEELDLSGNQLTDL-PEPLA 225

                         170
                  ....*....|....*...
gi 1034640891 317 YLVKLKSLSLEGIEISNI 334
Cdd:COG4886   226 NLTNLETLDLSNNQLTDL 243
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 111-348 3.10e-15

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 73.67  E-value: 3.10e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640891 111 LDCDETNLRAVPSVSS--NVTAMSLQWNLIRKLPP-DCFKNyhdLQKLYLQNNKITSISiyAFRGLNSLTKLYLSHNRIT 187
Cdd:cd21340     7 LYLNDKNITKIDNLSLckNLKVLYLYDNKITKIENlEFLTN---LTHLYLQNNQIEKIE--NLENLVNLKKLYLGGNRIS 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640891 188 FLKpGvFEDLHRLEWLIIEDNHLSRISPPTFyGLNSLILLVlmnnvltrlpdkplcqhmPRLHWLVMRKNKINHLNEntF 267
Cdd:cd21340    82 VVE-G-LENLTNLEELHIENQRLPPGEKLTF-DPRSLAALS------------------NSLRVLNISGNNIDSLEP--L 138

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640891 268 APLQKLDELDLGSNKIENLPPL--IFKDLKELSQLNLSYNPIQKiQANQFDYLVkLKSLSLE---GIEISNiQQRMFrpL 342
Cdd:cd21340   139 APLRNLEQLDASNNQISDLEELldLLSSWPSLRELDLTGNPVCK-KPKYRDKII-LASKSLEvldGKEITD-TERQF--L 213


                  ....*.
gi 1034640891 343 MNLSHM 348
Cdd:cd21340   214 KRLKAR 219
LRR_8 pfam13855
Leucine rich repeat;
152-210 1.43e-14

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 67.55  E-value: 1.43e-14
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1034640891 152 LQKLYLQNNKITSISIYAFRGLNSLTKLYLSHNRITFLKPGVFEDLHRLEWLIIEDNHL 210
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
175-234 8.21e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 59.85  E-value: 8.21e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640891 175 SLTKLYLSHNRITFLKPGVFEDLHRLEWLIIEDNHLSRISPPTFYGLNSLILLVLMNNVL 234
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
126-186 1.84e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 58.69  E-value: 1.84e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1034640891 126 SNVTAMSLQWNLIRKLPPDCFKNYHDLQKLYLQNNKITSISIYAFRGLNSLTKLYLSHNRI 186
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 27-62 2.86e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 51.82  E-value: 2.86e-09
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1034640891  27 CSLGYFPCGNiTKCLPQLLHCNGVDDCGNQADEDNC 62
Cdd:cd00112     1 CPPNEFRCAN-GRCIPSSWVCDGEDDCGDGSDEENC 35
LRR_8 pfam13855
Leucine rich repeat;
247-307 7.45e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 51.37  E-value: 7.45e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1034640891 247 PRLHWLVMRKNKINHLNENTFAPLQKLDELDLGSNKIENLPPLIFKDLKELSQLNLSYNPI 307
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
271-328 3.91e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.45  E-value: 3.91e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1034640891 271 QKLDELDLGSNKIENLPPLIFKDLKELSQLNLSYNPIQKIQANQFDYLVKLKSLSLEG 328
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSG 58
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 26-59 6.89e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 48.01  E-value: 6.89e-08
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1034640891   26 KCSLGYFPCGNiTKCLPQLLHCNGVDDCGNQADE 59
Cdd:smart00192   1 TCPPGEFQCDN-GRCIPSSWVCDGVDDCGDGSDE 33
LRR_8 pfam13855
Leucine rich repeat;
199-283 7.48e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.98  E-value: 7.48e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640891 199 RLEWLIIEDNHLSRISPPTFYGLNSLILLVLmnnvltrlpdkplcqhmprlhwlvmRKNKINHLNENTFAPLQKLDELDL 278
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDL-------------------------SNNLLTTLSPGAFSGLPSLRYLDL 56


                  ....*
gi 1034640891 279 GSNKI 283
Cdd:pfam13855  57 SGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 140-307 7.66e-07

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 50.05  E-value: 7.66e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640891 140 KLPPDCFKNYHDLQKLYLQNNKIT---SISIYAFRGLNSLTKLYLSHNRI-----TFLKPGVFEDLHRLEWLIIEDNHLS 211
Cdd:cd00116    71 QSLLQGLTKGCGLQELDLSDNALGpdgCGVLESLLRSSSLQELKLNNNGLgdrglRLLAKGLKDLPPALEKLVLGRNRLE 150

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640891 212 RIS----PPTFYGLNSLILLVLMNNVLTRLPDKPLCQ---HMPRLHWLVMRKNKINHLN----ENTFAPLQKLDELDLGS 280
Cdd:cd00116   151 GAScealAKALRANRDLKELNLANNGIGDAGIRALAEglkANCNLEVLDLNNNGLTDEGasalAETLASLKSLEVLNLGD 230

                         170       180       190
                  ....*....|....*....|....*....|..
gi 1034640891 281 NKIENLPPLIFKD-LKELSQ----LNLSYNPI 307
Cdd:cd00116   231 NNLTDAGAAALASaLLSPNIslltLSLSCNDI 262
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
25-62 1.99e-06

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 43.78  E-value: 1.99e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1034640891  25 VKCSLGYFPCGNiTKCLPQLLHCNGVDDCGNQADEDNC 62
Cdd:pfam00057   1 STCSPNEFQCGS-GECIPRSWVCDGDPDCGDGSDEENC 37
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 169-331 2.63e-06

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 48.51  E-value: 2.63e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640891 169 AFRGLNSLTKLYLSHNRITFLKPGVFEDLHR---LEWLIIEDNHLS-RISPPTFYGLNSLIL----LVLMNNVLTRLPDK 240
Cdd:cd00116    76 GLTKGCGLQELDLSDNALGPDGCGVLESLLRsssLQELKLNNNGLGdRGLRLLAKGLKDLPPalekLVLGRNRLEGASCE 155

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640891 241 PLC---QHMPRLHWLVMRKNKIN-----HLNEnTFAPLQKLDELDLGSNKI--ENLPPL--IFKDLKELSQLNLSYNPIQ 308
Cdd:cd00116   156 ALAkalRANRDLKELNLANNGIGdagirALAE-GLKANCNLEVLDLNNNGLtdEGASALaeTLASLKSLEVLNLGDNNLT 234

                         170       180
                  ....*....|....*....|....*...
gi 1034640891 309 KIQANQFD-----YLVKLKSLSLEGIEI 331
Cdd:cd00116   235 DAGAAALAsallsPNISLLTLSLSCNDI 262
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 176-326 4.21e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 48.69  E-value: 4.21e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640891 176 LTKLYLSHNRITFLKPGVFEDLHRLEWLIIEDNHLSRISPPTFYGLNSLILLVLMNNVLT-RLPDKPLcqHMPRLHWLVM 254
Cdd:PLN00113  382 LFKLILFSNSLEGEIPKSLGACRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQgRINSRKW--DMPSLQMLSL 459

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1034640891 255 RKNKINHLNENTFAPlQKLDELDLGSNKIENLPPLIFKDLKELSQLNLSYNPIQKIQANQFDYLVKLKSLSL 326
Cdd:PLN00113  460 ARNKFFGGLPDSFGS-KRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDL 530
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 152-305 6.08e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 48.31  E-value: 6.08e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640891 152 LQKLYLQNNKITSISIYAFRGLNSLTKLYLSHNRITFLKPGVFEDLHRLEWLIIEDNHLSRISPPTFYGLNSLILLVLMN 231
Cdd:PLN00113  214 LKWIYLGYNNLSGEIPYEIGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSD 293

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1034640891 232 NVLT-RLPDkpLCQHMPRLHWLVMRKNKINHLNENTFAPLQKLDELDLGSNKIENLPPLIFKDLKELSQLNLSYN 305
Cdd:PLN00113  294 NSLSgEIPE--LVIQLQNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSNKFSGEIPKNLGKHNNLTVLDLSTN 366
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
110-294 2.26e-05

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 46.08  E-value: 2.26e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640891 110 ELDCDETNLRAVPSV---SSNVTAMSLQWNLIRKLPpdCFKNYHDLQKLYLQNNKITSISIYAfrGLNSLTKLYLSHNRI 186
Cdd:COG4886   209 ELDLSGNQLTDLPEPlanLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQL 284

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640891 187 TFLKPGVFEDLHRLEWLIIEDNHLSRISPPTFYGLNSLILLVLMNNVLTRLPDKPLCQHMPRLHWLVMRKNKINHLNENT 266
Cdd:COG4886   285 TDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLT 364

                         170       180
                  ....*....|....*....|....*...
gi 1034640891 267 FAPLQKLDELDLGSNKIENLPPLIFKDL 294
Cdd:COG4886   365 LLLTLGLLGLLEATLLTLALLLLTLLLL 392
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 173-336 3.74e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 44.39  E-value: 3.74e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640891 173 LNSLTKLYLSHNRITFLkpGVFEDLHRLEWLIIEDNHLSRISpptfyGLNSLILLV---LMNNVLTRLPDkplCQHMPRL 249
Cdd:cd21340     1 LKRITHLYLNDKNITKI--DNLSLCKNLKVLYLYDNKITKIE-----NLEFLTNLThlyLQNNQIEKIEN---LENLVNL 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640891 250 HWLVMRKNKINHLN--ENtfapLQKLDELDLGSNKIENLPPLIFKD------LKELSQLNLSYNPIQKIQanQFDYLVKL 321
Cdd:cd21340    71 KKLYLGGNRISVVEglEN----LTNLEELHIENQRLPPGEKLTFDPrslaalSNSLRVLNISGNNIDSLE--PLAPLRNL 144

                         170
                  ....*....|....*
gi 1034640891 322 KSLSLEGIEISNIQQ 336
Cdd:cd21340   145 EQLDASNNQISDLEE 159
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 136-351 6.15e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 44.84  E-value: 6.15e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640891 136 NLIRKLPPDCFKNYHDLQKLYLQNNKIT-SISiyafRG-LNSLTKLYLSHNRITFLKPGVFEDLHRLEWLIIEDNHLSRI 213
Cdd:PLN00113  104 QLSGPIPDDIFTTSSSLRYLNLSNNNFTgSIP----RGsIPNLETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVLVGK 179

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640891 214 SPPTFYGLNSLILLVLMNNVLTRLPDKPLCQhMPRLHWLVMRKNKINHLNENTFAPLQKLDELDLGSNKIENLPPLIFKD 293
Cdd:PLN00113  180 IPNSLTNLTSLEFLTLASNQLVGQIPRELGQ-MKSLKWIYLGYNNLSGEIPYEIGGLTSLNHLDLVYNNLTGPIPSSLGN 258

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1034640891 294 LKELSQLNLSYNPIQ-KIQANQFDyLVKLKSLSLEGIEISNIQQRMFRPLMNLS--HMYHN 351
Cdd:PLN00113  259 LKNLQYLFLYQNKLSgPIPPSIFS-LQKLISLDLSDNSLSGEIPELVIQLQNLEilHLFSN 318
LRR_5 pfam13306
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ...
 140-233 3.46e-04

BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.


Pssm-ID: 463839 [Multi-domain]  Cd Length: 127  Bit Score: 39.84  E-value: 3.46e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640891 140 KLPPDCFKNyHDLQKLYLQNNkITSISIYAFRGLNSLTKLYLShNRITFLKPGVFEDLHrLEWLIIEDNhLSRISPPTFY 219
Cdd:pfam13306   2 SIGSYAFYN-CSLTSITIPSS-LTSIGEYAFSNCTSLKSITLP-SSLTSIGSYAFYNCS-LTSITIPSS-LTSIGEYAFS 76

                          90
                  ....*....|....
gi 1034640891 220 GLNSLILLVLMNNV 233
Cdd:pfam13306  77 NCSNLKSITLPSNL 90
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 126-313 3.76e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 42.53  E-value: 3.76e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640891 126 SNVTAMSLQWNLIRKLPPDCFKNYHDLQKLYLQNNKITSISIYAFRGLNSLTKLYLSHNRITFLKPGVFEDLHRLEWLII 205
Cdd:PLN00113  356 NNLTVLDLSTNNLTGEIPEGLCSSGNLFKLILFSNSLEGEIPKSLGACRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDI 435

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640891 206 EDNHLSRISPPTFYGLNSLILLVL-MNNVLTRLPDK---------PLCQH------------MPRLHWLVMRKNKINHLN 263
Cdd:PLN00113  436 SNNNLQGRINSRKWDMPSLQMLSLaRNKFFGGLPDSfgskrlenlDLSRNqfsgavprklgsLSELMQLKLSENKLSGEI 515

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1034640891 264 ENTFAPLQKLDELDLGSNKIENLPPLIFKDLKELSQLNLSYNPIQ-KIQAN 313
Cdd:PLN00113  516 PDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQNQLSgEIPKN 566
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 152-184 5.45e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 37.22  E-value: 5.45e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1034640891 152 LQKLYLQNNKITSISiyAFRGLNSLTKLYLSHN 184
Cdd:pfam12799   3 LEVLDLSNNQITDIP--PLAKLPNLETLDLSGN 33
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 125-234 6.51e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 41.76  E-value: 6.51e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640891 125 SSNVTAMSLQWNLIRKLPPDCFKNYHDLQKLYLQNNKITSISIYAFRGLNSLTKLYLSHNRITFLKPGVFEDLHRLEWLI 204
Cdd:PLN00113  474 SKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLD 553

                          90       100       110
                  ....*....|....*....|....*....|
gi 1034640891 205 IEDNHLSRISPPTFYGLNSLILLVLMNNVL 234
Cdd:PLN00113  554 LSQNQLSGEIPKNLGNVESLVQVNISHNHL 583
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 126-305 1.23e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 40.99  E-value: 1.23e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640891 126 SNVTAMSLQWNLIRKLPPDCFKNYHDLQKLYLQNNKITSISIYAFRGLNSLTKLYLSHNRITFLKPGVFEDLHRLEWLII 205
Cdd:PLN00113  140 PNLETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLVGQIPRELGQMKSLKWIYL 219

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640891 206 EDNHLSRISPPTFYGLNSLILLVLMNNVLTRlPDKPLCQHMPRLHWLVMRKNKINHLNENTFAPLQKLDELDLGSNKIEN 285
Cdd:PLN00113  220 GYNNLSGEIPYEIGGLTSLNHLDLVYNNLTG-PIPSSLGNLKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLSG 298

                         170       180
                  ....*....|....*....|
gi 1034640891 286 LPPLIFKDLKELSQLNLSYN 305
Cdd:PLN00113  299 EIPELVIQLQNLEILHLFSN 318
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 147-324 3.18e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 39.39  E-value: 3.18e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640891 147 KNYHDLQKLYLQNNKIT---SISI-YAFRGLNSLTKLYLSHNRITFlkPGVFEDLHRLEwliiednhlsrispptfyGLN 222
Cdd:COG5238   261 KNNTTVETLYLSGNQIGaegAIALaKALQGNTTLTSLDLSVNRIGD--EGAIALAEGLQ------------------GNK 320

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640891 223 SLILLVLMNNVLTRLPDKPLCQHM---PRLHWLVMRKNKI---------NHLNENTfaplqKLDELDLGSNKIENLPPL- 289
Cdd:COG5238   321 TLHTLNLAYNGIGAQGAIALAKALqenTTLHSLDLSDNQIgdegaialaKYLEGNT-----TLRELNLGKNNIGKQGAEa 395

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1034640891 290 IFKDLKE--LSQLNLSYNPI-QKIQANQFDYLVKLKSL 324
Cdd:COG5238   396 LIDALQTnrLHTLILDGNLIgAEAQQRLEQLLERIKSV 433
LRR_9 pfam14580
Leucine-rich repeat;
245-340 3.74e-03

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 37.82  E-value: 3.74e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640891 245 HMPRLHWLVMRKNKINHLNENTFAPLQKLDELDLGSNKIE---NLPPLIfkDLKELSQLNLSYNPIQKIQANQFDYLVKL 321
Cdd:pfam14580  62 LLRRLKTLLLNNNRICRIGEGLGEALPNLTELILTNNNLQelgDLDPLA--SLKKLTFLSLLRNPVTNKPHYRLYVIYKV 139

                          90       100
                  ....*....|....*....|....
gi 1034640891 322 KSLSLEGIEISNIQQR-----MFR 340
Cdd:pfam14580 140 PQLRLLDFRKVKQKERqaaekMFR 163
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 136-326 7.54e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 38.29  E-value: 7.54e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640891 136 NLIRKLPPDcFKNYHDLQKLYLQNNKITSI---SIYAFRGL-------NSLTK--------------LYLSHNRITFLKP 191
Cdd:PLN00113  247 NLTGPIPSS-LGNLKNLQYLFLYQNKLSGPippSIFSLQKLisldlsdNSLSGeipelviqlqnleiLHLFSNNFTGKIP 325

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640891 192 GVFEDLHRLEWLIIEDNHLSRISPPTFYGLNSLILLVLMNNVLT-RLPDKpLCQHmPRLHWLVMRKNKINHLNENTFAPL 270
Cdd:PLN00113  326 VALTSLPRLQVLQLWSNKFSGEIPKNLGKHNNLTVLDLSTNNLTgEIPEG-LCSS-GNLFKLILFSNSLEGEIPKSLGAC 403

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1034640891 271 QKLDELDLGSNKIENLPPLIFKDLKELSQLNLSYNPIQ-KIQANQFDyLVKLKSLSL 326
Cdd:PLN00113  404 RSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQgRINSRKWD-MPSLQMLSL 459
LRR_8 pfam13855
Leucine rich repeat;
296-353 9.20e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 34.42  E-value: 9.20e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640891 296 ELSQLNLSYNPIQKIQANQFDYLVKLKSLSLEGIEISNIQQRMFRPLMNLSHMY--HNLL 353
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDlsGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 152-332 9.45e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 37.91  E-value: 9.45e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640891 152 LQKLYLQNNKITSISIYAFRGLNSLTKLYLSHNRITFLKPGVFEDLHRLEWLIIEDNHLSRISPPTFYGLNSLILLVLMN 231
Cdd:PLN00113  334 LQVLQLWSNKFSGEIPKNLGKHNNLTVLDLSTNNLTGEIPEGLCSSGNLFKLILFSNSLEGEIPKSLGACRSLRRVRLQD 413

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640891 232 NVLT-RLPDKplCQHMPRLHWLVMRKNKINHLNENTFAPLQKLDELDLGSNKIENLPPLIFKDlKELSQLNLSYNPIQKI 310
Cdd:PLN00113  414 NSFSgELPSE--FTKLPLVYFLDISNNNLQGRINSRKWDMPSLQMLSLARNKFFGGLPDSFGS-KRLENLDLSRNQFSGA 490

                         170       180
                  ....*....|....*....|..
gi 1034640891 311 QANQFDYLVKLKSLSLEGIEIS 332
Cdd:PLN00113  491 VPRKLGSLSELMQLKLSENKLS 512
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 175-305 9.61e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 37.91  E-value: 9.61e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640891 175 SLTKLYLSHNRITFLKPGVFEDlHRLEWLIIEDNHLSRISPPTFYGLNSLILLVLMNNVLT-RLPDK-PLCQHMPRLHwl 252
Cdd:PLN00113  453 SLQMLSLARNKFFGGLPDSFGS-KRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSgEIPDElSSCKKLVSLD-- 529

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1034640891 253 vMRKNKINHLNENTFAPLQKLDELDLGSNKIENLPPLIFKDLKELSQLNLSYN 305
Cdd:PLN00113  530 -LSHNQLSGQIPASFSEMPVLSQLDLSQNQLSGEIPKNLGNVESLVQVNISHN 581
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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