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Conserved domains on  [gi|1034583933|ref|XP_016875912|]
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leucine-rich repeat-containing protein 63 isoform X3 [Homo sapiens]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
256-419 1.20e-27

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 115.03  E-value: 1.20e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034583933 256 ETITAMTNLAIVNCQVYGRNALNLKGFFILNCPDLTPLAF--QLIYLNLSFNDLHYFPTEILCLKNLQILKLRNNPIKEI 333
Cdd:COG4886    72 LLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNltNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDL 151

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034583933 334 PSEIQQLEFLRIFTIAFNLITVLPIGLFSLSYLEELDVSYNELTFIPNEIQKLRSLEKLTVDGNELSFFPHGILKL-NLT 412
Cdd:COG4886   152 PEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLtNLE 231


                  ....*..
gi 1034583933 413 KIQFENN 419
Cdd:COG4886   232 TLDLSNN 238
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
256-419 1.20e-27

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 115.03  E-value: 1.20e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034583933 256 ETITAMTNLAIVNCQVYGRNALNLKGFFILNCPDLTPLAF--QLIYLNLSFNDLHYFPTEILCLKNLQILKLRNNPIKEI 333
Cdd:COG4886    72 LLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNltNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDL 151

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034583933 334 PSEIQQLEFLRIFTIAFNLITVLPIGLFSLSYLEELDVSYNELTFIPNEIQKLRSLEKLTVDGNELSFFPHGILKL-NLT 412
Cdd:COG4886   152 PEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLtNLE 231


                  ....*..
gi 1034583933 413 KIQFENN 419
Cdd:COG4886   232 TLDLSNN 238
LRR_8 pfam13855
Leucine rich repeat;
343-399 2.55e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 53.30  E-value: 2.55e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1034583933 343 LRIFTIAFNLITVLPIGLFS-LSYLEELDVSYNELTFI-PNEIQKLRSLEKLTVDGNEL 399
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKgLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
PLN03150 PLN03150
hypothetical protein; Provisional
 323-400 1.70e-06

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 50.58  E-value: 1.70e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034583933 323 LKLRNNPIK-EIPSEIQQLEFLRIFTIAFNLIT-VLPIGLFSLSYLEELDVSYNELT-FIPNEIQKLRSLEKLTVDGNEL 399
Cdd:PLN03150  423 LGLDNQGLRgFIPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLNGNSL 502


                  .
gi 1034583933 400 S 400
Cdd:PLN03150  503 S 503
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 302-464 1.36e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 43.24  E-value: 1.36e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034583933 302 LSFNDLH--YFPTEILClKNLQILKLRNNPIKEIP------------------SEIQQLEFLRIFT---IAFNLITVLpI 358
Cdd:cd21340     7 LYLNDKNitKIDNLSLC-KNLKVLYLYDNKITKIEnlefltnlthlylqnnqiEKIENLENLVNLKklyLGGNRISVV-E 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034583933 359 GLFSLSYLEELDVSY------NELTFIPNEIQKL-RSLEKLTVDGNELSfFPHGILKL-NLTKIQFENnfthpcfwrdNY 430
Cdd:cd21340    85 GLENLTNLEELHIENqrlppgEKLTFDPRSLAALsNSLRVLNISGNNID-SLEPLAPLrNLEQLDASN----------NQ 153

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1034583933 431 LNNPQQLTQIIS-------LFIVQN---KLHKFYDKIPVEVQKL 464
Cdd:cd21340   154 ISDLEELLDLLSswpslreLDLTGNpvcKKPKYRDKIILASKSL 197
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
256-419 1.20e-27

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 115.03  E-value: 1.20e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034583933 256 ETITAMTNLAIVNCQVYGRNALNLKGFFILNCPDLTPLAF--QLIYLNLSFNDLHYFPTEILCLKNLQILKLRNNPIKEI 333
Cdd:COG4886    72 LLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNltNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDL 151

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034583933 334 PSEIQQLEFLRIFTIAFNLITVLPIGLFSLSYLEELDVSYNELTFIPNEIQKLRSLEKLTVDGNELSFFPHGILKL-NLT 412
Cdd:COG4886   152 PEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLtNLE 231


                  ....*..
gi 1034583933 413 KIQFENN 419
Cdd:COG4886   232 TLDLSNN 238
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
293-419 2.98e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 77.67  E-value: 2.98e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034583933 293 LAFQLIYLNLSFNDLHYFPTEILCLKNLQILKLRNNPikeipsEIQQLEFLRIFTIAFNLITVLPIGLFSLSYLEELDVS 372
Cdd:COG4886    71 LLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE------ELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLS 144

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1034583933 373 YNELTFIPNEIQKLRSLEKLTVDGNELSFFPHGILKL-NLTKIQFENN 419
Cdd:COG4886   145 NNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLtNLKELDLSNN 192
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
256-465 2.66e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 68.81  E-value: 2.66e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034583933 256 ETITAMTNLAIVNCqvyGRNALNLKGFFILNCPdltplafQLIYLNLSFNDLHYFPTEILCLKNLQILKLRNNPIKEIPS 335
Cdd:COG4886   153 EPLGNLTNLKSLDL---SNNQLTDLPEELGNLT-------NLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPE 222

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034583933 336 EIQQLEFLRIFTIAFNLITVLPI---------------------GLFSLSYLEELDVSYNELTFIPNEIQKLRSLEKLTV 394
Cdd:COG4886   223 PLANLTNLETLDLSNNQLTDLPElgnltnleeldlsnnqltdlpPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLL 302

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1034583933 395 DGNELSFFPHGILKLNLTKIQFENNFTHPCFWRDNYLNNPQQLTQIISLFIVQNKLHKFYDKIPVEVQKLL 465
Cdd:COG4886   303 LLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLG 373
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
249-419 5.06e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 64.57  E-value: 5.06e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034583933 249 TVAATRYETITAMTNLAIVNCQVYGRNALNLKGFFILNCPDLTPLAFQLIYLNLSFNDLHYFPTEILCLKNLQILKLRNN 328
Cdd:COG4886     4 LLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLS 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034583933 329 PIKEIPSEIQQLEFLRIFTIAFNLitvlpiGLFSLSYLEELDVSYNELTFIPNEIQKLRSLEKLTVDGNELSFFPHGILK 408
Cdd:COG4886    84 LLLLGLTDLGDLTNLTELDLSGNE------ELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGN 157

                         170
                  ....*....|..
gi 1034583933 409 L-NLTKIQFENN 419
Cdd:COG4886   158 LtNLKSLDLSNN 169
LRR_8 pfam13855
Leucine rich repeat;
343-399 2.55e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 53.30  E-value: 2.55e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1034583933 343 LRIFTIAFNLITVLPIGLFS-LSYLEELDVSYNELTFI-PNEIQKLRSLEKLTVDGNEL 399
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKgLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
PLN03150 PLN03150
hypothetical protein; Provisional
 323-400 1.70e-06

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 50.58  E-value: 1.70e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034583933 323 LKLRNNPIK-EIPSEIQQLEFLRIFTIAFNLIT-VLPIGLFSLSYLEELDVSYNELT-FIPNEIQKLRSLEKLTVDGNEL 399
Cdd:PLN03150  423 LGLDNQGLRgFIPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLNGNSL 502


                  .
gi 1034583933 400 S 400
Cdd:PLN03150  503 S 503
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 295-464 5.35e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 49.46  E-value: 5.35e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034583933 295 FQLIYLNLSFNDL-HYFPTEILCLKNLQILKLRNNP-IKEIPSEIQQLEFLRIFTIAFN-LITVLPIGLFSLSYLEELDV 371
Cdd:PLN00113  164 SSLKVLDLGGNVLvGKIPNSLTNLTSLEFLTLASNQlVGQIPRELGQMKSLKWIYLGYNnLSGEIPYEIGGLTSLNHLDL 243

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034583933 372 SYNELTF-IPNEIQKLRSLEKLTVDGNELSF-FPHGILKL-NLTKIQFEnnfthpcfwrDNYLNN--PQQLTQIISLFIV 446
Cdd:PLN00113  244 VYNNLTGpIPSSLGNLKNLQYLFLYQNKLSGpIPPSIFSLqKLISLDLS----------DNSLSGeiPELVIQLQNLEIL 313

                         170
                  ....*....|....*...
gi 1034583933 447 QNKLHKFYDKIPVEVQKL 464
Cdd:PLN00113  314 HLFSNNFTGKIPVALTSL 331
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
251-421 2.56e-05

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 47.00  E-value: 2.56e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034583933 251 AATRYETITAMTNlaivnCQVYGRNALNLKGFFILNCPDLTPLafQLIYLNLSFNDLHYFPTEILclKNLQILKLRNNPI 330
Cdd:PRK15370  162 AANREEAVQRMRD-----CLKNNKTELRLKILGLTTIPACIPE--QITTLILDNNELKSLPENLQ--GNIKTLYANSNQL 232

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034583933 331 KEIPSEIQqlEFLRIFTIAFNLITVLPIGLfsLSYLEELDVSYNELTFIPNEIQKlrSLEKLTVDGNEL----SFFPHGI 406
Cdd:PRK15370  233 TSIPATLP--DTIQEMELSINRITELPERL--PSALQSLDLFHNKISCLPENLPE--ELRYLSVYDNSIrtlpAHLPSGI 306

                         170
                  ....*....|....*
gi 1034583933 407 LKLNLtkiqFENNFT 421
Cdd:PRK15370  307 THLNV----QSNSLT 317
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 302-464 1.36e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 43.24  E-value: 1.36e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034583933 302 LSFNDLH--YFPTEILClKNLQILKLRNNPIKEIP------------------SEIQQLEFLRIFT---IAFNLITVLpI 358
Cdd:cd21340     7 LYLNDKNitKIDNLSLC-KNLKVLYLYDNKITKIEnlefltnlthlylqnnqiEKIENLENLVNLKklyLGGNRISVV-E 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034583933 359 GLFSLSYLEELDVSY------NELTFIPNEIQKL-RSLEKLTVDGNELSfFPHGILKL-NLTKIQFENnfthpcfwrdNY 430
Cdd:cd21340    85 GLENLTNLEELHIENqrlppgEKLTFDPRSLAALsNSLRVLNISGNNID-SLEPLAPLrNLEQLDASN----------NQ 153

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1034583933 431 LNNPQQLTQIIS-------LFIVQN---KLHKFYDKIPVEVQKL 464
Cdd:cd21340   154 ISDLEELLDLLSswpslreLDLTGNpvcKKPKYRDKIILASKSL 197
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
256-451 2.59e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 43.38  E-value: 2.59e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034583933 256 ETITAMTNLAIVNCqvyGRNALNlkgffilNCPDLTPLAfQLIYLNLSFNDLHYFPtEILCLKNLQILKLRNNPIKEIPS 335
Cdd:COG4886   222 EPLANLTNLETLDL---SNNQLT-------DLPELGNLT-NLEELDLSNNQLTDLP-PLANLTNLKTLDLSNNQLTDLKL 289

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034583933 336 EIQQLEFLRIFTIAFNLITVLPIGLFSLSYLEELDVSYNELTFIPNEIQKLRSLEKLTVDGNELSFFPHGILKLNLTkIQ 415
Cdd:COG4886   290 KELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLL-LT 368

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1034583933 416 FENNFTHPCFWRDNYLNNPQQLTQIISLFIVQNKLH 451
Cdd:COG4886   369 LGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLT 404
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 290-399 6.15e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 39.45  E-value: 6.15e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034583933 290 LTPLAFQLIYL---NLSFNDLHY-FPTEILCL-KNLQILKLRNNPIK-EIPS-EIQQLEFLRIFTIAFNLITVLPIGLFS 362
Cdd:PLN00113   85 ISSAIFRLPYIqtiNLSNNQLSGpIPDDIFTTsSSLRYLNLSNNNFTgSIPRgSIPNLETLDLSNNMLSGEIPNDIGSFS 164

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1034583933 363 lsYLEELDVSYNELT-FIPNEIQKLRSLEKLTVDGNEL 399
Cdd:PLN00113  165 --SLKVLDLGGNVLVgKIPNSLTNLTSLEFLTLASNQL 200
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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