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Conserved domains on  [gi|1034593342|ref|XP_016878338|]
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cadherin-13 isoform X3 [Homo sapiens]

Protein Classification

Cadherin_pro domain-containing protein( domain architecture ID 10555544)

Cadherin_pro domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cadherin_pro super family cl07391
Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent ...
 74-158 7.14e-34

Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent cell-cell adhesion. They are activated through cleavage of a prosequence in the late Golgi. This domain corresponds to the folded region of the prosequence, and is termed the prodomain. The prodomain shows structural resemblance to the cadherin domain, but lacks all the features known to be important for cadherin-cadherin interactions.


The actual alignment was detected with superfamily member pfam08758:

Pssm-ID: 471661  Cd Length: 90  Bit Score: 117.04  E-value: 7.14e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034593342  74 CTPGFQQKVFHINQPAEFIEDQSILNLTFSDCKGNDKLRYEVSSPYFKVNSDGGLVALRNITAVGK--TLFVHARTPHAE 151
Cdd:pfam08758   2 CKPGFSEEVYTFSVPRRLEEGQPLLNVKFNDCTGRKKTLYESSDPRFKVNTDGTVTAKRPVTLHGRqtSFLVHAWDSHGE 81


                  ....*..
gi 1034593342 152 DMAELVI 158
Cdd:pfam08758  82 KMASVKV 88
 
Name Accession Description Interval E-value
Cadherin_pro pfam08758
Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent ...
 74-158 7.14e-34

Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent cell-cell adhesion. They are activated through cleavage of a prosequence in the late Golgi. This domain corresponds to the folded region of the prosequence, and is termed the prodomain. The prodomain shows structural resemblance to the cadherin domain, but lacks all the features known to be important for cadherin-cadherin interactions.


Pssm-ID: 462590  Cd Length: 90  Bit Score: 117.04  E-value: 7.14e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034593342  74 CTPGFQQKVFHINQPAEFIEDQSILNLTFSDCKGNDKLRYEVSSPYFKVNSDGGLVALRNITAVGK--TLFVHARTPHAE 151
Cdd:pfam08758   2 CKPGFSEEVYTFSVPRRLEEGQPLLNVKFNDCTGRKKTLYESSDPRFKVNTDGTVTAKRPVTLHGRqtSFLVHAWDSHGE 81


                  ....*..
gi 1034593342 152 DMAELVI 158
Cdd:pfam08758  82 KMASVKV 88
Cadherin_pro smart01055
Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent ...
 74-158 1.77e-22

Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent cell-cell adhesion. They are activated through cleavage of a prosequence in the late Golgi. This domain corresponds to the folded region of the prosequence, and is termed the prodomain. The prodomain shows structural resemblance to the cadherin domain, but lacks all the features known to be important for cadherin-cadherin interactions.


Pssm-ID: 214999  Cd Length: 87  Bit Score: 87.72  E-value: 1.77e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034593342   74 CTPGFQQKVFHINQPAEFIEDQSILNLTFSDCKGNDKLRYEVSSPYFKVNSDGGLVALRNITAVG--KTLFVHARTPHAE 151
Cdd:smart01055   1 CKPGFSEEKYTFHVPSHLEAGQPLGRVNFEECLGSARLQFESSDPDFRVLEDGTVYATRPVSLSSekKSFTVLAWDSQGQ 80


                   ....*..
gi 1034593342  152 DMAELVI 158
Cdd:smart01055  81 EKKEIKV 87
 
Name Accession Description Interval E-value
Cadherin_pro pfam08758
Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent ...
 74-158 7.14e-34

Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent cell-cell adhesion. They are activated through cleavage of a prosequence in the late Golgi. This domain corresponds to the folded region of the prosequence, and is termed the prodomain. The prodomain shows structural resemblance to the cadherin domain, but lacks all the features known to be important for cadherin-cadherin interactions.


Pssm-ID: 462590  Cd Length: 90  Bit Score: 117.04  E-value: 7.14e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034593342  74 CTPGFQQKVFHINQPAEFIEDQSILNLTFSDCKGNDKLRYEVSSPYFKVNSDGGLVALRNITAVGK--TLFVHARTPHAE 151
Cdd:pfam08758   2 CKPGFSEEVYTFSVPRRLEEGQPLLNVKFNDCTGRKKTLYESSDPRFKVNTDGTVTAKRPVTLHGRqtSFLVHAWDSHGE 81


                  ....*..
gi 1034593342 152 DMAELVI 158
Cdd:pfam08758  82 KMASVKV 88
Cadherin_pro smart01055
Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent ...
 74-158 1.77e-22

Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent cell-cell adhesion. They are activated through cleavage of a prosequence in the late Golgi. This domain corresponds to the folded region of the prosequence, and is termed the prodomain. The prodomain shows structural resemblance to the cadherin domain, but lacks all the features known to be important for cadherin-cadherin interactions.


Pssm-ID: 214999  Cd Length: 87  Bit Score: 87.72  E-value: 1.77e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034593342   74 CTPGFQQKVFHINQPAEFIEDQSILNLTFSDCKGNDKLRYEVSSPYFKVNSDGGLVALRNITAVG--KTLFVHARTPHAE 151
Cdd:smart01055   1 CKPGFSEEKYTFHVPSHLEAGQPLGRVNFEECLGSARLQFESSDPDFRVLEDGTVYATRPVSLSSekKSFTVLAWDSQGQ 80


                   ....*..
gi 1034593342  152 DMAELVI 158
Cdd:smart01055  81 EKKEIKV 87
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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