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Conserved domains on  [gi|1034604750|ref|XP_016881482|]
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GREB1-like protein isoform X6 [Homo sapiens]

Protein Classification

GREB1 domain-containing protein( domain architecture ID 12174538)

GREB1 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GREB1 pfam15782
GREB1 N-terminal region; GREB1 (gene regulated by estrogen in breast cancer 1) was first ...
 1-1111 0e+00

GREB1 N-terminal region; GREB1 (gene regulated by estrogen in breast cancer 1) was first identified as an oestrogen-regulated gene expressed in breast cancer. Its exact function is not known but its expression is regulated by the coordinated binding of oestrogen-receptors to distal sites interacting with Pol II to activate gene transcription from core promoters located at a considerable distance from the greb1 gene.


:

Pssm-ID: 464866  Cd Length: 1102  Bit Score: 1924.16  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034604750    1 MGNSYAGQLKSARFEEALHNSIEASLRCSSVVPRPIFSQLYLDPDQH-PFSSADVKPKVEDLDKDlvnrytQNGSldfsn 79
Cdd:pfam15782    1 MGNSYAGQLKTTRFEEVLHNSIEASLRSNSVVPRPVFSQLYLEAEQQlSSLEGGSRNENDDEEED------EDGS----- 69

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034604750   80 nltvnemeddeddeemsDSNSPPIPYSQKPAPEGSCTTDGFCQAGKDLRLVSLCMEQIDIPAGFLLVGAKSPNLPEHILV 159
Cdd:pfam15782   70 -----------------ESNSPPIPYQMKPPPEGCCTTDGFCQAGKDLRLVSLASEQIDVPAGFLLVGAKSPSLPEHLLV 132

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034604750  160 CAVDKRFLPDDHGKNALLGFSGNCIGCGERGFRYFTEFSNHINLKLTTQPKKQKHLKYYLVRSSQGVLSKGPLICWK--E 237
Cdd:pfam15782  133 CAVDKRFLPDDNGRNALLGFSGNCVGCGEKGFRYFTEFSNHINLKLTTQPKKQKHLKYYLVRNSQGVLVKGPLICWKgsE 212

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034604750  238 CRSRQSSASCHSIKPSSSVSSTVTPENGTTNGYKSGFTQTD-------AANGNSSHGGKGSASSSTPAHtGNYSLSPRPS 310
Cdd:pfam15782  213 CRSRQSSASTCSSTPTSSPESPGLSANGSSEPYPTPASQLDsghepqtAAVSHQVSNGNQSPPSSTLAK-LNPSAPPRPS 291

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034604750  311 YasgdQATMFISGPPKKRHRGWYPGSPLPQPGLVVPVPTVRPLSRTEPLLSAPVPQTPLTGILQPRPIPA-----GETVI 385
Cdd:pfam15782  292 V----LGTHSNSGPPKKRHKGWSPESSVPDSTLKVPVPSSRPSTSVSSVLTNGSPQSCLTQVLPPGPASAplvppGESVI 367

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034604750  386 VPENLLSNSGVRPVILIGYGTLPYFYGNVGDIVVSPLLVNCYKIPQLENKDLEKLGLTGSQFLSVENMILLTIQYLVRLG 465
Cdd:pfam15782  368 VPDNLLNTCRLRPVILKGHGNLPYLTGNVNDVVVSPLLVSCYKSSQTLPRAYEQYGLSPIQPLSVEMQILLTVYYLVQLG 447

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034604750  466 PDQVPLREEFEQIMLKAMQEFTLRE--RALQIGAQCVP--------VSPGQLPWLARLIASVSQDLVHVVVTQNSLAEGI 535
Cdd:pfam15782  448 PDQVPLIEDLEQIFMRSWRESHLSEirQYQQMHAQCLPqtpssqqpVTPAQLPWLAQLAASSCNEGVVVVECQYSLAEGL 527

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034604750  536 SETLRTLSEMRHYQRlpDYVVVICASKIRGNEFCVVVLGQHQSRALAESMLTTSEFLKEISYELITGKVSFLASHFKTTS 615
Cdd:pfam15782  528 SETFRRLMEGKLENT--NYVVIICASRGRGTESCVVVTGKHQARALAESMLSPSEGLKEISYELITGKVSELASHFKTLC 605

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034604750  616 LGDDLDKLLEKMQQRRGDSVVTPFDGDLNECVSPQEAAAMIPTQNLDLDNETFHIYQPQLTVARKLLSQVCAIADSGSQS 695
Cdd:pfam15782  606 PDGDLDKLLDKFQQERQGEVSSPLSGSQEEAVSSQEAAAMVPTTCTEYSVEWHEIRPIQLAVARKLLSHVCAIADSSTQN 685

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034604750  696 LDLGHFSKVDFIIIVPRSEVLVQQTLQRIRQSGVLVDLGLEENGTAHQRAEKYVVRLDNEIQTKFEVFMRRVKQNPYTLF 775
Cdd:pfam15782  686 LDLGSFSKVDFLILVPPSEVTYQQTVLHLWQSGVLVDLGLEQASTSKQKAEQYVVKLDSEAQAKFESFLQEVKQNPYTLF 765

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034604750  776 VLVHDNSHVELTSVISGSLSHSEPSHGLADRVINCREVLEAFNLLVLQVSSFPYTLQTQQSRISSSNEVHWIQL-DTGED 854
Cdd:pfam15782  766 VLVHDHAHWDLTSAISSSYSHSESGLGLVDRLLNCREVKDAPNILILHVTSFPYALQTQQTRISPYNEIHWPSAfSNGVD 845

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034604750  855 VGCEEKLYFGLSEYSKSLQWGITSPLLRCDETFEKMVNTLLERYPRLHSMVVRCYLLIQQYSEALMALTTMASLRDHSTP 934
Cdd:pfam15782  846 LYHERTRYFGLSEYLESTQSGHSLPLLRYDSSFESMVSALLERFPKLHSAVIRTYVLIQHYSAALMAVSGSSQLKDHTSV 925

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034604750  935 ETLSIMDDLISSPGKNKSGRGHMLIIRVPSVQLAMLAKERLQEVRDKLGLQYRFEIILGNPATELSVATHFVARLKSWRG 1014
Cdd:pfam15782  926 ETLEIVQDLINAPQQCPSGHGHMVLLRIPSLQLAMVAYERLCRVRDKLGLEYRFEIILGNPNSELTIGKHFVDQLKAWRK 1005

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034604750 1015 NEPEEWIPRTYQDLDGLPCIVILTGKDPLGETFPRSLKYCDLRLIDSSYLTRTALEQEVGLACCYVSKEVIRGPTVALDL 1094
Cdd:pfam15782 1006 IEDADWVPRTYLELEGLPCILILSGKDPLGESLPRSLKYCDLRLINSSYLTRTALEQELGLAAYYVSKEVPREPGVGSDL 1085

                         1130
                   ....*....|....*..
gi 1034604750 1095 SGKEQERAAVSENDSDE 1111
Cdd:pfam15782 1086 SESDAEKLSSTDNEDEE 1102
GREB1_C super family cl48431
GREB1 C-terminal region; GREB1 (gene regulated by estrogen in breast cancer 1) was first ...
 1229-1826 0e+00

GREB1 C-terminal region; GREB1 (gene regulated by estrogen in breast cancer 1) was first identified as an oestrogen-regulated gene expressed in breast cancer. Its exact function is not known but its expression is regulated by the coordinated binding of oestrogen-receptors to distal sites interacting with Pol II to activate gene transcription from core promoters located at a considerable distance from the greb1 gene.


The actual alignment was detected with superfamily member pfam20267:

Pssm-ID: 466417  Cd Length: 688  Bit Score: 1127.93  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034604750 1229 PPVVILSKAAYSLLGSQKSGKLPSSSSLLPHADVAWVSSLRPLLNKDMSSEEQSLYYRQWTLARQHHADYSNQldPASGT 1308
Cdd:pfam20267    1 PPIVILPKAAYDIITSSDSSGLPRSSSLLPHASVAWASSFRPLLSKMMTCTEQSLYYRQWTVPRQHHMDYSNR--TEGRS 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034604750 1309 RNFHPRRLLLTGPPQVGKTGSYLQFLRILFRMLIRLLEVDVYDEEEINTD-HNESSEVSQSEGEPWPDIESFSKMPFDVS 1387
Cdd:pfam20267   79 DNFHPRRLLLSGPPQVGKTGAYLQFLRILSRMLIRLLEVDVYDEEEININrQSESVQHYHQPNDPWPDLEIFKKMPFDYT 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034604750 1388 VHDPKYSLMSLVYTEkLAGVKQEVIKESKVEE--PRKRETVSIMLTKYAAYNTFHHCEQCRQYMDFTSASQMSDSTLHAF 1465
Cdd:pfam20267  159 IHDPKYEDASPVYSP-LYKPKSEGKPNPRRQEdvYLRRRTTRIRLSKYAAYNTYHHCEQCHQYMGFNPRYQMYESTLHAF 237

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034604750 1466 TFSSSMLGEEVQLYFIIPKSKESHFVFSKQGKHLESMRLPLVSDKqNLNAVKSPIFTPSSGRHEHGLLNLFHAMEGISHL 1545
Cdd:pfam20267  238 TFSSSMLGEEIQLHFIIPKSKEHHFVFSQPGGQLESMRLPLVSDK-NPDCIKSPIFTPTTGRHEHGLFNLYHAMDGASHL 316

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034604750 1546 HLLVVKEYEMPLYRKYWPNHIMLVLPGMFNNAGVGAARFLIKELSYHNLELERNRLEELGIKRQCVWPFIVMMDDSCVLW 1625
Cdd:pfam20267  317 HILVVKEYEMAVYKKYWPNHIMLVLPSIFNGAGVGAAHFLIKELSYHNLELERNRQEELGVKRQDVWPFIVIADDSCVMW 396

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034604750 1626 NIHSVQEPSsqpmevGVSSKNVSLKTVLQHIEATPKIVHYAILGIQKWSSKLTSQSLKAPFSRCHVHDFILLNTDLTQNV 1705
Cdd:pfam20267  397 NAVDVDAES------GPSERNVSLKQVLQHMEATPKITHYALLGIRKWSSKLLSKKLKEPFSRCHLHDFILLNVDLTQNV 470

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034604750 1706 QYDFNRYFCEDADFNLRTNSSGLLICRFNNFSLMKKHVQVGGQRDFIIKPKIMvsESLAPILPLQYICAPDSEHTLLAAP 1785
Cdd:pfam20267  471 QYDQNRFTCEDVDFNLRLHSAGLLICRFNNFSVMKKQIAVGGYRDFHIKPKVS--DNPTSVSPSQYICAPDSKHTFLAAP 548

                          570       580       590       600
                   ....*....|....*....|....*....|....*....|.
gi 1034604750 1786 AQFLLEKFLQHASYKLFPKAIHNFRSPVLAIDCYLNIGPEV 1826
Cdd:pfam20267  549 AQLLLEKYLQHTSHKLFPLSLKNYNHPVLSVDCYLNLGPEI 589
 
Name Accession Description Interval E-value
GREB1 pfam15782
GREB1 N-terminal region; GREB1 (gene regulated by estrogen in breast cancer 1) was first ...
 1-1111 0e+00

GREB1 N-terminal region; GREB1 (gene regulated by estrogen in breast cancer 1) was first identified as an oestrogen-regulated gene expressed in breast cancer. Its exact function is not known but its expression is regulated by the coordinated binding of oestrogen-receptors to distal sites interacting with Pol II to activate gene transcription from core promoters located at a considerable distance from the greb1 gene.


Pssm-ID: 464866  Cd Length: 1102  Bit Score: 1924.16  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034604750    1 MGNSYAGQLKSARFEEALHNSIEASLRCSSVVPRPIFSQLYLDPDQH-PFSSADVKPKVEDLDKDlvnrytQNGSldfsn 79
Cdd:pfam15782    1 MGNSYAGQLKTTRFEEVLHNSIEASLRSNSVVPRPVFSQLYLEAEQQlSSLEGGSRNENDDEEED------EDGS----- 69

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034604750   80 nltvnemeddeddeemsDSNSPPIPYSQKPAPEGSCTTDGFCQAGKDLRLVSLCMEQIDIPAGFLLVGAKSPNLPEHILV 159
Cdd:pfam15782   70 -----------------ESNSPPIPYQMKPPPEGCCTTDGFCQAGKDLRLVSLASEQIDVPAGFLLVGAKSPSLPEHLLV 132

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034604750  160 CAVDKRFLPDDHGKNALLGFSGNCIGCGERGFRYFTEFSNHINLKLTTQPKKQKHLKYYLVRSSQGVLSKGPLICWK--E 237
Cdd:pfam15782  133 CAVDKRFLPDDNGRNALLGFSGNCVGCGEKGFRYFTEFSNHINLKLTTQPKKQKHLKYYLVRNSQGVLVKGPLICWKgsE 212

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034604750  238 CRSRQSSASCHSIKPSSSVSSTVTPENGTTNGYKSGFTQTD-------AANGNSSHGGKGSASSSTPAHtGNYSLSPRPS 310
Cdd:pfam15782  213 CRSRQSSASTCSSTPTSSPESPGLSANGSSEPYPTPASQLDsghepqtAAVSHQVSNGNQSPPSSTLAK-LNPSAPPRPS 291

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034604750  311 YasgdQATMFISGPPKKRHRGWYPGSPLPQPGLVVPVPTVRPLSRTEPLLSAPVPQTPLTGILQPRPIPA-----GETVI 385
Cdd:pfam15782  292 V----LGTHSNSGPPKKRHKGWSPESSVPDSTLKVPVPSSRPSTSVSSVLTNGSPQSCLTQVLPPGPASAplvppGESVI 367

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034604750  386 VPENLLSNSGVRPVILIGYGTLPYFYGNVGDIVVSPLLVNCYKIPQLENKDLEKLGLTGSQFLSVENMILLTIQYLVRLG 465
Cdd:pfam15782  368 VPDNLLNTCRLRPVILKGHGNLPYLTGNVNDVVVSPLLVSCYKSSQTLPRAYEQYGLSPIQPLSVEMQILLTVYYLVQLG 447

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034604750  466 PDQVPLREEFEQIMLKAMQEFTLRE--RALQIGAQCVP--------VSPGQLPWLARLIASVSQDLVHVVVTQNSLAEGI 535
Cdd:pfam15782  448 PDQVPLIEDLEQIFMRSWRESHLSEirQYQQMHAQCLPqtpssqqpVTPAQLPWLAQLAASSCNEGVVVVECQYSLAEGL 527

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034604750  536 SETLRTLSEMRHYQRlpDYVVVICASKIRGNEFCVVVLGQHQSRALAESMLTTSEFLKEISYELITGKVSFLASHFKTTS 615
Cdd:pfam15782  528 SETFRRLMEGKLENT--NYVVIICASRGRGTESCVVVTGKHQARALAESMLSPSEGLKEISYELITGKVSELASHFKTLC 605

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034604750  616 LGDDLDKLLEKMQQRRGDSVVTPFDGDLNECVSPQEAAAMIPTQNLDLDNETFHIYQPQLTVARKLLSQVCAIADSGSQS 695
Cdd:pfam15782  606 PDGDLDKLLDKFQQERQGEVSSPLSGSQEEAVSSQEAAAMVPTTCTEYSVEWHEIRPIQLAVARKLLSHVCAIADSSTQN 685

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034604750  696 LDLGHFSKVDFIIIVPRSEVLVQQTLQRIRQSGVLVDLGLEENGTAHQRAEKYVVRLDNEIQTKFEVFMRRVKQNPYTLF 775
Cdd:pfam15782  686 LDLGSFSKVDFLILVPPSEVTYQQTVLHLWQSGVLVDLGLEQASTSKQKAEQYVVKLDSEAQAKFESFLQEVKQNPYTLF 765

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034604750  776 VLVHDNSHVELTSVISGSLSHSEPSHGLADRVINCREVLEAFNLLVLQVSSFPYTLQTQQSRISSSNEVHWIQL-DTGED 854
Cdd:pfam15782  766 VLVHDHAHWDLTSAISSSYSHSESGLGLVDRLLNCREVKDAPNILILHVTSFPYALQTQQTRISPYNEIHWPSAfSNGVD 845

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034604750  855 VGCEEKLYFGLSEYSKSLQWGITSPLLRCDETFEKMVNTLLERYPRLHSMVVRCYLLIQQYSEALMALTTMASLRDHSTP 934
Cdd:pfam15782  846 LYHERTRYFGLSEYLESTQSGHSLPLLRYDSSFESMVSALLERFPKLHSAVIRTYVLIQHYSAALMAVSGSSQLKDHTSV 925

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034604750  935 ETLSIMDDLISSPGKNKSGRGHMLIIRVPSVQLAMLAKERLQEVRDKLGLQYRFEIILGNPATELSVATHFVARLKSWRG 1014
Cdd:pfam15782  926 ETLEIVQDLINAPQQCPSGHGHMVLLRIPSLQLAMVAYERLCRVRDKLGLEYRFEIILGNPNSELTIGKHFVDQLKAWRK 1005

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034604750 1015 NEPEEWIPRTYQDLDGLPCIVILTGKDPLGETFPRSLKYCDLRLIDSSYLTRTALEQEVGLACCYVSKEVIRGPTVALDL 1094
Cdd:pfam15782 1006 IEDADWVPRTYLELEGLPCILILSGKDPLGESLPRSLKYCDLRLINSSYLTRTALEQELGLAAYYVSKEVPREPGVGSDL 1085

                         1130
                   ....*....|....*..
gi 1034604750 1095 SGKEQERAAVSENDSDE 1111
Cdd:pfam15782 1086 SESDAEKLSSTDNEDEE 1102
GREB1_C pfam20267
GREB1 C-terminal region; GREB1 (gene regulated by estrogen in breast cancer 1) was first ...
 1229-1826 0e+00

GREB1 C-terminal region; GREB1 (gene regulated by estrogen in breast cancer 1) was first identified as an oestrogen-regulated gene expressed in breast cancer. Its exact function is not known but its expression is regulated by the coordinated binding of oestrogen-receptors to distal sites interacting with Pol II to activate gene transcription from core promoters located at a considerable distance from the greb1 gene.


Pssm-ID: 466417  Cd Length: 688  Bit Score: 1127.93  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034604750 1229 PPVVILSKAAYSLLGSQKSGKLPSSSSLLPHADVAWVSSLRPLLNKDMSSEEQSLYYRQWTLARQHHADYSNQldPASGT 1308
Cdd:pfam20267    1 PPIVILPKAAYDIITSSDSSGLPRSSSLLPHASVAWASSFRPLLSKMMTCTEQSLYYRQWTVPRQHHMDYSNR--TEGRS 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034604750 1309 RNFHPRRLLLTGPPQVGKTGSYLQFLRILFRMLIRLLEVDVYDEEEINTD-HNESSEVSQSEGEPWPDIESFSKMPFDVS 1387
Cdd:pfam20267   79 DNFHPRRLLLSGPPQVGKTGAYLQFLRILSRMLIRLLEVDVYDEEEININrQSESVQHYHQPNDPWPDLEIFKKMPFDYT 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034604750 1388 VHDPKYSLMSLVYTEkLAGVKQEVIKESKVEE--PRKRETVSIMLTKYAAYNTFHHCEQCRQYMDFTSASQMSDSTLHAF 1465
Cdd:pfam20267  159 IHDPKYEDASPVYSP-LYKPKSEGKPNPRRQEdvYLRRRTTRIRLSKYAAYNTYHHCEQCHQYMGFNPRYQMYESTLHAF 237

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034604750 1466 TFSSSMLGEEVQLYFIIPKSKESHFVFSKQGKHLESMRLPLVSDKqNLNAVKSPIFTPSSGRHEHGLLNLFHAMEGISHL 1545
Cdd:pfam20267  238 TFSSSMLGEEIQLHFIIPKSKEHHFVFSQPGGQLESMRLPLVSDK-NPDCIKSPIFTPTTGRHEHGLFNLYHAMDGASHL 316

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034604750 1546 HLLVVKEYEMPLYRKYWPNHIMLVLPGMFNNAGVGAARFLIKELSYHNLELERNRLEELGIKRQCVWPFIVMMDDSCVLW 1625
Cdd:pfam20267  317 HILVVKEYEMAVYKKYWPNHIMLVLPSIFNGAGVGAAHFLIKELSYHNLELERNRQEELGVKRQDVWPFIVIADDSCVMW 396

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034604750 1626 NIHSVQEPSsqpmevGVSSKNVSLKTVLQHIEATPKIVHYAILGIQKWSSKLTSQSLKAPFSRCHVHDFILLNTDLTQNV 1705
Cdd:pfam20267  397 NAVDVDAES------GPSERNVSLKQVLQHMEATPKITHYALLGIRKWSSKLLSKKLKEPFSRCHLHDFILLNVDLTQNV 470

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034604750 1706 QYDFNRYFCEDADFNLRTNSSGLLICRFNNFSLMKKHVQVGGQRDFIIKPKIMvsESLAPILPLQYICAPDSEHTLLAAP 1785
Cdd:pfam20267  471 QYDQNRFTCEDVDFNLRLHSAGLLICRFNNFSVMKKQIAVGGYRDFHIKPKVS--DNPTSVSPSQYICAPDSKHTFLAAP 548

                          570       580       590       600
                   ....*....|....*....|....*....|....*....|.
gi 1034604750 1786 AQFLLEKFLQHASYKLFPKAIHNFRSPVLAIDCYLNIGPEV 1826
Cdd:pfam20267  549 AQLLLEKYLQHTSHKLFPLSLKNYNHPVLSVDCYLNLGPEI 589
 
Name Accession Description Interval E-value
GREB1 pfam15782
GREB1 N-terminal region; GREB1 (gene regulated by estrogen in breast cancer 1) was first ...
 1-1111 0e+00

GREB1 N-terminal region; GREB1 (gene regulated by estrogen in breast cancer 1) was first identified as an oestrogen-regulated gene expressed in breast cancer. Its exact function is not known but its expression is regulated by the coordinated binding of oestrogen-receptors to distal sites interacting with Pol II to activate gene transcription from core promoters located at a considerable distance from the greb1 gene.


Pssm-ID: 464866  Cd Length: 1102  Bit Score: 1924.16  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034604750    1 MGNSYAGQLKSARFEEALHNSIEASLRCSSVVPRPIFSQLYLDPDQH-PFSSADVKPKVEDLDKDlvnrytQNGSldfsn 79
Cdd:pfam15782    1 MGNSYAGQLKTTRFEEVLHNSIEASLRSNSVVPRPVFSQLYLEAEQQlSSLEGGSRNENDDEEED------EDGS----- 69

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034604750   80 nltvnemeddeddeemsDSNSPPIPYSQKPAPEGSCTTDGFCQAGKDLRLVSLCMEQIDIPAGFLLVGAKSPNLPEHILV 159
Cdd:pfam15782   70 -----------------ESNSPPIPYQMKPPPEGCCTTDGFCQAGKDLRLVSLASEQIDVPAGFLLVGAKSPSLPEHLLV 132

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034604750  160 CAVDKRFLPDDHGKNALLGFSGNCIGCGERGFRYFTEFSNHINLKLTTQPKKQKHLKYYLVRSSQGVLSKGPLICWK--E 237
Cdd:pfam15782  133 CAVDKRFLPDDNGRNALLGFSGNCVGCGEKGFRYFTEFSNHINLKLTTQPKKQKHLKYYLVRNSQGVLVKGPLICWKgsE 212

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034604750  238 CRSRQSSASCHSIKPSSSVSSTVTPENGTTNGYKSGFTQTD-------AANGNSSHGGKGSASSSTPAHtGNYSLSPRPS 310
Cdd:pfam15782  213 CRSRQSSASTCSSTPTSSPESPGLSANGSSEPYPTPASQLDsghepqtAAVSHQVSNGNQSPPSSTLAK-LNPSAPPRPS 291

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034604750  311 YasgdQATMFISGPPKKRHRGWYPGSPLPQPGLVVPVPTVRPLSRTEPLLSAPVPQTPLTGILQPRPIPA-----GETVI 385
Cdd:pfam15782  292 V----LGTHSNSGPPKKRHKGWSPESSVPDSTLKVPVPSSRPSTSVSSVLTNGSPQSCLTQVLPPGPASAplvppGESVI 367

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034604750  386 VPENLLSNSGVRPVILIGYGTLPYFYGNVGDIVVSPLLVNCYKIPQLENKDLEKLGLTGSQFLSVENMILLTIQYLVRLG 465
Cdd:pfam15782  368 VPDNLLNTCRLRPVILKGHGNLPYLTGNVNDVVVSPLLVSCYKSSQTLPRAYEQYGLSPIQPLSVEMQILLTVYYLVQLG 447

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034604750  466 PDQVPLREEFEQIMLKAMQEFTLRE--RALQIGAQCVP--------VSPGQLPWLARLIASVSQDLVHVVVTQNSLAEGI 535
Cdd:pfam15782  448 PDQVPLIEDLEQIFMRSWRESHLSEirQYQQMHAQCLPqtpssqqpVTPAQLPWLAQLAASSCNEGVVVVECQYSLAEGL 527

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034604750  536 SETLRTLSEMRHYQRlpDYVVVICASKIRGNEFCVVVLGQHQSRALAESMLTTSEFLKEISYELITGKVSFLASHFKTTS 615
Cdd:pfam15782  528 SETFRRLMEGKLENT--NYVVIICASRGRGTESCVVVTGKHQARALAESMLSPSEGLKEISYELITGKVSELASHFKTLC 605

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034604750  616 LGDDLDKLLEKMQQRRGDSVVTPFDGDLNECVSPQEAAAMIPTQNLDLDNETFHIYQPQLTVARKLLSQVCAIADSGSQS 695
Cdd:pfam15782  606 PDGDLDKLLDKFQQERQGEVSSPLSGSQEEAVSSQEAAAMVPTTCTEYSVEWHEIRPIQLAVARKLLSHVCAIADSSTQN 685

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034604750  696 LDLGHFSKVDFIIIVPRSEVLVQQTLQRIRQSGVLVDLGLEENGTAHQRAEKYVVRLDNEIQTKFEVFMRRVKQNPYTLF 775
Cdd:pfam15782  686 LDLGSFSKVDFLILVPPSEVTYQQTVLHLWQSGVLVDLGLEQASTSKQKAEQYVVKLDSEAQAKFESFLQEVKQNPYTLF 765

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034604750  776 VLVHDNSHVELTSVISGSLSHSEPSHGLADRVINCREVLEAFNLLVLQVSSFPYTLQTQQSRISSSNEVHWIQL-DTGED 854
Cdd:pfam15782  766 VLVHDHAHWDLTSAISSSYSHSESGLGLVDRLLNCREVKDAPNILILHVTSFPYALQTQQTRISPYNEIHWPSAfSNGVD 845

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034604750  855 VGCEEKLYFGLSEYSKSLQWGITSPLLRCDETFEKMVNTLLERYPRLHSMVVRCYLLIQQYSEALMALTTMASLRDHSTP 934
Cdd:pfam15782  846 LYHERTRYFGLSEYLESTQSGHSLPLLRYDSSFESMVSALLERFPKLHSAVIRTYVLIQHYSAALMAVSGSSQLKDHTSV 925

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034604750  935 ETLSIMDDLISSPGKNKSGRGHMLIIRVPSVQLAMLAKERLQEVRDKLGLQYRFEIILGNPATELSVATHFVARLKSWRG 1014
Cdd:pfam15782  926 ETLEIVQDLINAPQQCPSGHGHMVLLRIPSLQLAMVAYERLCRVRDKLGLEYRFEIILGNPNSELTIGKHFVDQLKAWRK 1005

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034604750 1015 NEPEEWIPRTYQDLDGLPCIVILTGKDPLGETFPRSLKYCDLRLIDSSYLTRTALEQEVGLACCYVSKEVIRGPTVALDL 1094
Cdd:pfam15782 1006 IEDADWVPRTYLELEGLPCILILSGKDPLGESLPRSLKYCDLRLINSSYLTRTALEQELGLAAYYVSKEVPREPGVGSDL 1085

                         1130
                   ....*....|....*..
gi 1034604750 1095 SGKEQERAAVSENDSDE 1111
Cdd:pfam15782 1086 SESDAEKLSSTDNEDEE 1102
GREB1_C pfam20267
GREB1 C-terminal region; GREB1 (gene regulated by estrogen in breast cancer 1) was first ...
 1229-1826 0e+00

GREB1 C-terminal region; GREB1 (gene regulated by estrogen in breast cancer 1) was first identified as an oestrogen-regulated gene expressed in breast cancer. Its exact function is not known but its expression is regulated by the coordinated binding of oestrogen-receptors to distal sites interacting with Pol II to activate gene transcription from core promoters located at a considerable distance from the greb1 gene.


Pssm-ID: 466417  Cd Length: 688  Bit Score: 1127.93  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034604750 1229 PPVVILSKAAYSLLGSQKSGKLPSSSSLLPHADVAWVSSLRPLLNKDMSSEEQSLYYRQWTLARQHHADYSNQldPASGT 1308
Cdd:pfam20267    1 PPIVILPKAAYDIITSSDSSGLPRSSSLLPHASVAWASSFRPLLSKMMTCTEQSLYYRQWTVPRQHHMDYSNR--TEGRS 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034604750 1309 RNFHPRRLLLTGPPQVGKTGSYLQFLRILFRMLIRLLEVDVYDEEEINTD-HNESSEVSQSEGEPWPDIESFSKMPFDVS 1387
Cdd:pfam20267   79 DNFHPRRLLLSGPPQVGKTGAYLQFLRILSRMLIRLLEVDVYDEEEININrQSESVQHYHQPNDPWPDLEIFKKMPFDYT 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034604750 1388 VHDPKYSLMSLVYTEkLAGVKQEVIKESKVEE--PRKRETVSIMLTKYAAYNTFHHCEQCRQYMDFTSASQMSDSTLHAF 1465
Cdd:pfam20267  159 IHDPKYEDASPVYSP-LYKPKSEGKPNPRRQEdvYLRRRTTRIRLSKYAAYNTYHHCEQCHQYMGFNPRYQMYESTLHAF 237

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034604750 1466 TFSSSMLGEEVQLYFIIPKSKESHFVFSKQGKHLESMRLPLVSDKqNLNAVKSPIFTPSSGRHEHGLLNLFHAMEGISHL 1545
Cdd:pfam20267  238 TFSSSMLGEEIQLHFIIPKSKEHHFVFSQPGGQLESMRLPLVSDK-NPDCIKSPIFTPTTGRHEHGLFNLYHAMDGASHL 316

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034604750 1546 HLLVVKEYEMPLYRKYWPNHIMLVLPGMFNNAGVGAARFLIKELSYHNLELERNRLEELGIKRQCVWPFIVMMDDSCVLW 1625
Cdd:pfam20267  317 HILVVKEYEMAVYKKYWPNHIMLVLPSIFNGAGVGAAHFLIKELSYHNLELERNRQEELGVKRQDVWPFIVIADDSCVMW 396

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034604750 1626 NIHSVQEPSsqpmevGVSSKNVSLKTVLQHIEATPKIVHYAILGIQKWSSKLTSQSLKAPFSRCHVHDFILLNTDLTQNV 1705
Cdd:pfam20267  397 NAVDVDAES------GPSERNVSLKQVLQHMEATPKITHYALLGIRKWSSKLLSKKLKEPFSRCHLHDFILLNVDLTQNV 470

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034604750 1706 QYDFNRYFCEDADFNLRTNSSGLLICRFNNFSLMKKHVQVGGQRDFIIKPKIMvsESLAPILPLQYICAPDSEHTLLAAP 1785
Cdd:pfam20267  471 QYDQNRFTCEDVDFNLRLHSAGLLICRFNNFSVMKKQIAVGGYRDFHIKPKVS--DNPTSVSPSQYICAPDSKHTFLAAP 548

                          570       580       590       600
                   ....*....|....*....|....*....|....*....|.
gi 1034604750 1786 AQFLLEKFLQHASYKLFPKAIHNFRSPVLAIDCYLNIGPEV 1826
Cdd:pfam20267  549 AQLLLEKYLQHTSHKLFPLSLKNYNHPVLSVDCYLNLGPEI 589
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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