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Conserved domains on  [gi|1034609383|ref|XP_016882756|]
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zinc finger protein 227 isoform X3 [Homo sapiens]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12017129)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development, and in regulating viral replication and transcription

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 23-63 4.45e-19

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


:

Pssm-ID: 460171  Cd Length: 42  Bit Score: 80.98  E-value: 4.45e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1034609383  23 VTFKDVAVVFSREELRLLDLTQRKLYRDVMVENFKNLVAVG 63
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
378-751 3.26e-10

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 63.18  E-value: 3.26e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034609383 378 KPYKCEECGKGFTQAAHFHIHQRVHTGEKPYKCDV--CGKGFSHNSPLICHRRVHTGEKPYKCEACGKGFTRNTDLHIHF 455
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034609383 456 RVHTGE-KPYKCKECGKGFSQ--------ASNLQVHQNVHTGEKRFKCET--------------CGKGFSQSSKLQTHQR 512
Cdd:COG5048   112 SSSSNSnDNNLLSSHSLPPSSrdpqlpdlLSISNLRNNPLPGNNSSSVNTpqsnslhpplpansLSKDPSSNLSLLISSN 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034609383 513 VHTGEKPYRCDVCGKDFSYSSNLKLHQVIHTGEKPYKCEECGKGF------SWRSNLHAHQRVHSGEKPYKCEQCDKSFS 586
Cdd:COG5048   192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSpksllsQSPSSLSSSDSSSSASESPRSSLPTASSQ 271

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034609383 587 QAIDFRVHQRVHTG-EKPYKCGVCGKGFSQSSGLQSHQR--VHTGE--KPYKCDV--CGKGFRYSSQFIYHQRGHTGEKP 659
Cdd:COG5048   272 SSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISP 351

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034609383 660 YKC--EECGKGFGRSLNLRHHQRVH-----TGEKPHICE--ECGKAFSLPSNLRVHLGVHT--REKLFKCEECGKGFSQS 728
Cdd:COG5048   352 AKEklLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETLsnSCIRNFKRDSNLSLHIITHLsfRPYNCKNPPCSKSFNRH 431

                         410       420
                  ....*....|....*....|...
gi 1034609383 729 ARLEAHQRVHTGEKPYKCDICDK 751
Cdd:COG5048   432 YNLIPHKKIHTNHAPLLCSILKS 454
zf-H2C2_2 pfam13465
Zinc-finger double domain;
314-335 2.97e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.97e-03
                          10        20
                  ....*....|....*....|..
gi 1034609383 314 HYRTHTGEKPYKCEECGKCFSQ 335
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 23-63 4.45e-19

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 80.98  E-value: 4.45e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1034609383  23 VTFKDVAVVFSREELRLLDLTQRKLYRDVMVENFKNLVAVG 63
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
23-65 4.49e-19

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 81.48  E-value: 4.49e-19
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1034609383   23 VTFKDVAVVFSREELRLLDLTQRKLYRDVMVENFKNLVAVGSK 65
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQ 43
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 23-60 5.93e-15

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 69.12  E-value: 5.93e-15
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1034609383  23 VTFKDVAVVFSREELRLLDLTQRKLYRDVMVENFKNLV 60
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLV 38
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
378-751 3.26e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 63.18  E-value: 3.26e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034609383 378 KPYKCEECGKGFTQAAHFHIHQRVHTGEKPYKCDV--CGKGFSHNSPLICHRRVHTGEKPYKCEACGKGFTRNTDLHIHF 455
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034609383 456 RVHTGE-KPYKCKECGKGFSQ--------ASNLQVHQNVHTGEKRFKCET--------------CGKGFSQSSKLQTHQR 512
Cdd:COG5048   112 SSSSNSnDNNLLSSHSLPPSSrdpqlpdlLSISNLRNNPLPGNNSSSVNTpqsnslhpplpansLSKDPSSNLSLLISSN 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034609383 513 VHTGEKPYRCDVCGKDFSYSSNLKLHQVIHTGEKPYKCEECGKGF------SWRSNLHAHQRVHSGEKPYKCEQCDKSFS 586
Cdd:COG5048   192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSpksllsQSPSSLSSSDSSSSASESPRSSLPTASSQ 271

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034609383 587 QAIDFRVHQRVHTG-EKPYKCGVCGKGFSQSSGLQSHQR--VHTGE--KPYKCDV--CGKGFRYSSQFIYHQRGHTGEKP 659
Cdd:COG5048   272 SSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISP 351

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034609383 660 YKC--EECGKGFGRSLNLRHHQRVH-----TGEKPHICE--ECGKAFSLPSNLRVHLGVHT--REKLFKCEECGKGFSQS 728
Cdd:COG5048   352 AKEklLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETLsnSCIRNFKRDSNLSLHIITHLsfRPYNCKNPPCSKSFNRH 431

                         410       420
                  ....*....|....*....|...
gi 1034609383 729 ARLEAHQRVHTGEKPYKCDICDK 751
Cdd:COG5048   432 YNLIPHKKIHTNHAPLLCSILKS 454
zf-H2C2_2 pfam13465
Zinc-finger double domain;
366-391 7.59e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 7.59e-04
                          10        20
                  ....*....|....*....|....*.
gi 1034609383 366 NLRVHQRVHRGEKPYKCEECGKGFTQ 391
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
314-335 2.97e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.97e-03
                          10        20
                  ....*....|....*....|..
gi 1034609383 314 HYRTHTGEKPYKCEECGKCFSQ 335
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 23-63 4.45e-19

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 80.98  E-value: 4.45e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1034609383  23 VTFKDVAVVFSREELRLLDLTQRKLYRDVMVENFKNLVAVG 63
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
23-65 4.49e-19

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 81.48  E-value: 4.49e-19
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1034609383   23 VTFKDVAVVFSREELRLLDLTQRKLYRDVMVENFKNLVAVGSK 65
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQ 43
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 23-60 5.93e-15

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 69.12  E-value: 5.93e-15
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1034609383  23 VTFKDVAVVFSREELRLLDLTQRKLYRDVMVENFKNLV 60
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLV 38
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
378-751 3.26e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 63.18  E-value: 3.26e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034609383 378 KPYKCEECGKGFTQAAHFHIHQRVHTGEKPYKCDV--CGKGFSHNSPLICHRRVHTGEKPYKCEACGKGFTRNTDLHIHF 455
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034609383 456 RVHTGE-KPYKCKECGKGFSQ--------ASNLQVHQNVHTGEKRFKCET--------------CGKGFSQSSKLQTHQR 512
Cdd:COG5048   112 SSSSNSnDNNLLSSHSLPPSSrdpqlpdlLSISNLRNNPLPGNNSSSVNTpqsnslhpplpansLSKDPSSNLSLLISSN 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034609383 513 VHTGEKPYRCDVCGKDFSYSSNLKLHQVIHTGEKPYKCEECGKGF------SWRSNLHAHQRVHSGEKPYKCEQCDKSFS 586
Cdd:COG5048   192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSpksllsQSPSSLSSSDSSSSASESPRSSLPTASSQ 271

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034609383 587 QAIDFRVHQRVHTG-EKPYKCGVCGKGFSQSSGLQSHQR--VHTGE--KPYKCDV--CGKGFRYSSQFIYHQRGHTGEKP 659
Cdd:COG5048   272 SSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISP 351

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034609383 660 YKC--EECGKGFGRSLNLRHHQRVH-----TGEKPHICE--ECGKAFSLPSNLRVHLGVHT--REKLFKCEECGKGFSQS 728
Cdd:COG5048   352 AKEklLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETLsnSCIRNFKRDSNLSLHIITHLsfRPYNCKNPPCSKSFNRH 431

                         410       420
                  ....*....|....*....|...
gi 1034609383 729 ARLEAHQRVHTGEKPYKCDICDK 751
Cdd:COG5048   432 YNLIPHKKIHTNHAPLLCSILKS 454
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
247-678 1.42e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 61.25  E-value: 1.42e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034609383 247 EKCFSQSSHLRTHQRIHPGEKLNRCHESGD---CFNKSSFHSYQSNHTGEKSYRC-DSCGKGFSSSTGLIIHYRTHTGEK 322
Cdd:COG5048    40 TDSFSRLEHLTRHIRSHTGEKPSQCSYSGCdksFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLSSSSSNSND 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034609383 323 PYKCEECGKCFSQSSNFQCHQRVHTEEKPYKCEECGkgfgwsvnlrvhqrvhrgekpykceecGKGFTQAAHFHIHQRVH 402
Cdd:COG5048   120 NNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNN---------------------------SSSVNTPQSNSLHPPLP 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034609383 403 TGEKpykcdvCGKGFSHNSPLICHRRVHTGEKPYKCEACGKgFTRNTDLHIHFRVHTGEKPYKCKECGKGFSQASNLQVH 482
Cdd:COG5048   173 ANSL------SKDPSSNLSLLISSNVSTSIPSSSENSPLSS-SYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSP 245

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034609383 483 QNVHTGEKRFKCETCG------KGFSQSSKLQTHQRVHTG-EKPYRCDVCGKDFSYSSNLKLHQ--VIHTGE--KPYKCE 551
Cdd:COG5048   246 SSLSSSDSSSSASESPrsslptASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCP 325

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034609383 552 E--CGKGFSWRSNLHAHQRVHSGEKPYKC--EQCDKSFSQAIDFRVHQRV--HTGEKPYKCGV-----CGKGFSQSSGLQ 620
Cdd:COG5048   326 YslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLqqYKDLKNDKKSEtlsnsCIRNFKRDSNLS 405

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034609383 621 SHQRVHTGEKP--YKCDVCGKGFRYSSQFIYHQRGHTGEKPYKCEECGKgFGRSLNLRHH 678
Cdd:COG5048   406 LHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNH 464
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 572-655 2.26e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 47.41  E-value: 2.26e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034609383 572 GEKPYKCE--QCDKSFSQAIDFRVHqRVHtgekpykcGVCGKGFSQSSGLQSHQRVHTGEKPYKCDVCGKGFRYSSQFIY 649
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYH-MLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ....*.
gi 1034609383 650 HqRGHT 655
Cdd:COG5189   417 H-RKHS 421
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
492-770 1.79e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 44.69  E-value: 1.79e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034609383 492 FKCETCGKGFSQSSKLQTHQRVHTGEKPYRCDVCGKDFSYSSNLKL--HQVIHTGEKPYKCEECGKG--FSWRSNLHAHQ 567
Cdd:COG5048    34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELsrHLRTHHNNPSDLNSKSLPLsnSKASSSSLSSS 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034609383 568 RVHS--GEKPYKCEQCDKSFSQAIDFRVHQRVHTGEKPYKCGVCGKGFSQSSGLQ-------------------SHQRVH 626
Cdd:COG5048   114 SSNSndNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHpplpanslskdpssnlsllISSNVS 193

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034609383 627 TGEKPYKCDVCGKGFRYSSQFIYHQRGHTGEKPYKCEECGKGFGRSLNLRHHQRVHTGEKPHICEECG------KAFSLP 700
Cdd:COG5048   194 TSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPrsslptASSQSS 273

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1034609383 701 SNLRVHLGVHTREKL-FKCEECGKGFSQSARLEAHQR--VHTGE--KPYKCDI--CDKDFRHRSRLTYHQKVHTGKK 770
Cdd:COG5048   274 SPNESDSSSEKGFSLpIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSIS 350
zf-H2C2_2 pfam13465
Zinc-finger double domain;
366-391 7.59e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 7.59e-04
                          10        20
                  ....*....|....*....|....*.
gi 1034609383 366 NLRVHQRVHRGEKPYKCEECGKGFTQ 391
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
619-643 7.97e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 7.97e-04
                          10        20
                  ....*....|....*....|....*
gi 1034609383 619 LQSHQRVHTGEKPYKCDVCGKGFRY 643
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
507-531 8.21e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 8.21e-04
                          10        20
                  ....*....|....*....|....*
gi 1034609383 507 LQTHQRVHTGEKPYRCDVCGKDFSY 531
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 460-538 1.08e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.40  E-value: 1.08e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034609383 460 GEKPYKCK--ECGKGFSQASNLQVHQnvhtgekrfKCETCGKGFSQSSKLQTHQRVHTGEKPYRCDVCGKDFSYSSNLKL 537
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHM---------LHGHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  .
gi 1034609383 538 H 538
Cdd:COG5189   417 H 417
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 589-683 1.42e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.01  E-value: 1.42e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034609383 589 IDFRVHQRVHTGEKPYKCGV--CGKGFSQSSGLQSHqRVHTGEKPYKCDVCGKgfryssqfIYHQRGHTGEKPYKCEECG 666
Cdd:COG5189   335 IDTPSRMLKVKDGKPYKCPVegCNKKYKNQNGLKYH-MLHGHQNQKLHENPSP--------EKMNIFSAKDKPYRCEVCD 405

                          90
                  ....*....|....*..
gi 1034609383 667 KGFGRSLNLRHHqRVHT 683
Cdd:COG5189   406 KRYKNLNGLKYH-RKHS 421
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 544-627 1.42e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.01  E-value: 1.42e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034609383 544 GEKPYKCE--ECGKGFSWRSNLHAHqRVHSGEKPYKCEQCDKSfsqaidfrVHQRVHTGEKPYKCGVCGKGFSQSSGLQS 621
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYH-MLHGHQNQKLHENPSPE--------KMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ....*.
gi 1034609383 622 HqRVHT 627
Cdd:COG5189   417 H-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
730-755 2.30e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 2.30e-03
                          10        20
                  ....*....|....*....|....*.
gi 1034609383 730 RLEAHQRVHTGEKPYKCDICDKDFRH 755
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
534-558 2.89e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.89e-03
                          10        20
                  ....*....|....*....|....*
gi 1034609383 534 NLKLHQVIHTGEKPYKCEECGKGFS 558
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
314-335 2.97e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.97e-03
                          10        20
                  ....*....|....*....|..
gi 1034609383 314 HYRTHTGEKPYKCEECGKCFSQ 335
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 684-764 3.58e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.47  E-value: 3.58e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034609383 684 GEKPHICE--ECGKAFSLPSNLRVHLgvhtreklfKCEECGKGFSQSARLEAHQRVHTGEKPYKCDICDKDFRHRSRLTY 761
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHM---------LHGHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ...
gi 1034609383 762 HQK 764
Cdd:COG5189   417 HRK 419
zf-H2C2_2 pfam13465
Zinc-finger double domain;
566-587 4.45e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 4.45e-03
                          10        20
                  ....*....|....*....|..
gi 1034609383 566 HQRVHSGEKPYKCEQCDKSFSQ 587
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
454-475 5.58e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 5.58e-03
                          10        20
                  ....*....|....*....|..
gi 1034609383 454 HFRVHTGEKPYKCKECGKGFSQ 475
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
398-419 5.74e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 5.74e-03
                          10        20
                  ....*....|....*....|..
gi 1034609383 398 HQRVHTGEKPYKCDVCGKGFSH 419
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 376-427 6.06e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 39.70  E-value: 6.06e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1034609383 376 GEKPYKCE--ECGKGFTQA-------AHFHIHQRVH------------TGEKPYKCDVCGKGFSHNSPLICHR 427
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQnglkyhmLHGHQNQKLHenpspekmnifsAKDKPYRCEVCDKRYKNLNGLKYHR 418
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 628-708 6.67e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 39.70  E-value: 6.67e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034609383 628 GEKPYKCDVCGKGFRYSSQF--IYHQR-GHTGEKPYKCEECGKgfgrslnlrhHQRVHTGEKPHICEECGKAFSLPSNLR 704
Cdd:COG5189   346 DGKPYKCPVEGCNKKYKNQNglKYHMLhGHQNQKLHENPSPEK----------MNIFSAKDKPYRCEVCDKRYKNLNGLK 415


                  ....
gi 1034609383 705 VHLG 708
Cdd:COG5189   416 YHRK 419
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 464-486 7.97e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.58  E-value: 7.97e-03
                          10        20
                  ....*....|....*....|...
gi 1034609383 464 YKCKECGKGFSQASNLQVHQNVH 486
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
590-615 8.26e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 8.26e-03
                          10        20
                  ....*....|....*....|....*.
gi 1034609383 590 DFRVHQRVHTGEKPYKCGVCGKGFSQ 615
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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