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Conserved domains on  [gi|2217336345|ref|XP_016883586|]
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solute carrier family 4 member 11 isoform X8 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HCO3_cotransp super family cl46638
HCO3- transporter family; This family contains Band 3 anion exchange proteins that exchange ...
 368-456 2.79e-35

HCO3- transporter family; This family contains Band 3 anion exchange proteins that exchange CL-/HCO3-. This family also includes cotransporters of Na+/HCO3-.


The actual alignment was detected with superfamily member pfam00955:

Pssm-ID: 480978  Cd Length: 497  Bit Score: 136.89  E-value: 2.79e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217336345 368 PFGkGIREDIARRFPLYPLDFTDGIigknkaVGKYITTTLFLYFACLLPTIAFGSLNDENTDGAIDVQKTIAGQSIGGLL 447
Cdd:pfam00955   2 LFG-GLINDIKRRYPHYLSDFTDAL------NLQCLASIIFLYFACLSPAITFGGLLGDATDGYIGVSESILSQAIGGII 74


                  ....*....
gi 2217336345 448 YALFSGQPL 456
Cdd:pfam00955  75 FALFAGQPL 83
Band_3_cyto super family cl26877
Band 3 cytoplasmic domain; This family contains the cytoplasmic domain of the Band 3 anion ...
 274-456 3.63e-17

Band 3 cytoplasmic domain; This family contains the cytoplasmic domain of the Band 3 anion exchange proteins that exchange Cl-/HCO3-. Band 3 constitutes the most abundant polypeptide in the red blood cell membrane, comprising 25% of the total membrane protein. The cytoplasmic domain of band 3 functions primarily as an anchoring site for other membrane-associated proteins. Included among the protein ligands of cdb3 are ankyrin, protein 4.2, protein 4.1, glyceraldehyde-3-phosphate dehydrogenase (GAPDH), phosphofructokinase, aldolase, hemoglobin, hemichromes, and the protein tyrosine kinase (p72syk).


The actual alignment was detected with superfamily member TIGR00834:

Pssm-ID: 452680 [Multi-domain]  Cd Length: 900  Bit Score: 84.43  E-value: 3.63e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217336345 274 VRFVILVLAP--PKMKSTktamEVARTFATMFSDIAF---------RQKLLETRTE---------------EEFKEALVH 327
Cdd:TIGR00834 220 VRFLFVLLGPsgPGKDYH----EIGRAIATLMSDEVFhdaayladdRDDLLAGIDEfldcsivlppgewdpEIRLEPPAP 295

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217336345 328 -QRQLL-------TMVSHGPVAPRTKERSTVSLPAHRHPEPPKCKDFVPFGKGIReDIARRFPLYPLDFTDGIigkNKAV 399
Cdd:TIGR00834 296 lQRELLrkryepsTVRPENPTMGGDTEPEDGGSEGPHGDDDPLQRTGRPFGGLIR-DIKRRYPHYLSDFTDAL---NPQC 371

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2217336345 400 gkyITTTLFLYFACLLPTIAFGSLNDENTDGAIDVQKTIAGQSIGGLLYALFSGQPL 456
Cdd:TIGR00834 372 ---LAAVIFIYFAALSPAITFGGLLGEKTRNMMGVSELLISTAVQGVLFALLAAQPL 425
 
Name Accession Description Interval E-value
HCO3_cotransp pfam00955
HCO3- transporter family; This family contains Band 3 anion exchange proteins that exchange ...
 368-456 2.79e-35

HCO3- transporter family; This family contains Band 3 anion exchange proteins that exchange CL-/HCO3-. This family also includes cotransporters of Na+/HCO3-.


Pssm-ID: 460009  Cd Length: 497  Bit Score: 136.89  E-value: 2.79e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217336345 368 PFGkGIREDIARRFPLYPLDFTDGIigknkaVGKYITTTLFLYFACLLPTIAFGSLNDENTDGAIDVQKTIAGQSIGGLL 447
Cdd:pfam00955   2 LFG-GLINDIKRRYPHYLSDFTDAL------NLQCLASIIFLYFACLSPAITFGGLLGDATDGYIGVSESILSQAIGGII 74


                  ....*....
gi 2217336345 448 YALFSGQPL 456
Cdd:pfam00955  75 FALFAGQPL 83
ae TIGR00834
anion exchange protein; The Anion Exchanger (AE) Family (TC 2.A.31)Characterized protein ...
 274-456 3.63e-17

anion exchange protein; The Anion Exchanger (AE) Family (TC 2.A.31)Characterized protein members of the AE family are found only in animals.They preferentially catalyze anion exchange (antiport) reactions, typically acting as HCO3-:Cl- antiporters, but also transporting a range of other inorganic and organic anions. Additionally, renal Na+:HCO3- cotransporters have been found to be members of the AE family. They catalyze the reabsorption of HCO3- in the renal proximal tubule. [Transport and binding proteins, Anions]


Pssm-ID: 273290 [Multi-domain]  Cd Length: 900  Bit Score: 84.43  E-value: 3.63e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217336345 274 VRFVILVLAP--PKMKSTktamEVARTFATMFSDIAF---------RQKLLETRTE---------------EEFKEALVH 327
Cdd:TIGR00834 220 VRFLFVLLGPsgPGKDYH----EIGRAIATLMSDEVFhdaayladdRDDLLAGIDEfldcsivlppgewdpEIRLEPPAP 295

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217336345 328 -QRQLL-------TMVSHGPVAPRTKERSTVSLPAHRHPEPPKCKDFVPFGKGIReDIARRFPLYPLDFTDGIigkNKAV 399
Cdd:TIGR00834 296 lQRELLrkryepsTVRPENPTMGGDTEPEDGGSEGPHGDDDPLQRTGRPFGGLIR-DIKRRYPHYLSDFTDAL---NPQC 371

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2217336345 400 gkyITTTLFLYFACLLPTIAFGSLNDENTDGAIDVQKTIAGQSIGGLLYALFSGQPL 456
Cdd:TIGR00834 372 ---LAAVIFIYFAALSPAITFGGLLGEKTRNMMGVSELLISTAVQGVLFALLAAQPL 425
PtsN COG1762
Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type) [Carbohydrate ...
 249-327 1.57e-05

Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type) [Carbohydrate transport and metabolism, Signal transduction mechanisms];


Pssm-ID: 441368 [Multi-domain]  Cd Length: 150  Bit Score: 44.84  E-value: 1.57e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217336345 249 KALQKRHVCISRLVRPQNWGENSCE-VRFVILVLAPPKmkSTKTAMEVARTFATMFSDIAFRQKLLETRTEEEFKEALVH 327
Cdd:COG1762    71 EGVKKPGIAVARLKEPVDFGAMDGEpVDLVFLLAAPED--DSEEHLKLLAELARLLSDEEFREKLLNAKSPEEILELLKE 148
 
Name Accession Description Interval E-value
HCO3_cotransp pfam00955
HCO3- transporter family; This family contains Band 3 anion exchange proteins that exchange ...
 368-456 2.79e-35

HCO3- transporter family; This family contains Band 3 anion exchange proteins that exchange CL-/HCO3-. This family also includes cotransporters of Na+/HCO3-.


Pssm-ID: 460009  Cd Length: 497  Bit Score: 136.89  E-value: 2.79e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217336345 368 PFGkGIREDIARRFPLYPLDFTDGIigknkaVGKYITTTLFLYFACLLPTIAFGSLNDENTDGAIDVQKTIAGQSIGGLL 447
Cdd:pfam00955   2 LFG-GLINDIKRRYPHYLSDFTDAL------NLQCLASIIFLYFACLSPAITFGGLLGDATDGYIGVSESILSQAIGGII 74


                  ....*....
gi 2217336345 448 YALFSGQPL 456
Cdd:pfam00955  75 FALFAGQPL 83
ae TIGR00834
anion exchange protein; The Anion Exchanger (AE) Family (TC 2.A.31)Characterized protein ...
 274-456 3.63e-17

anion exchange protein; The Anion Exchanger (AE) Family (TC 2.A.31)Characterized protein members of the AE family are found only in animals.They preferentially catalyze anion exchange (antiport) reactions, typically acting as HCO3-:Cl- antiporters, but also transporting a range of other inorganic and organic anions. Additionally, renal Na+:HCO3- cotransporters have been found to be members of the AE family. They catalyze the reabsorption of HCO3- in the renal proximal tubule. [Transport and binding proteins, Anions]


Pssm-ID: 273290 [Multi-domain]  Cd Length: 900  Bit Score: 84.43  E-value: 3.63e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217336345 274 VRFVILVLAP--PKMKSTktamEVARTFATMFSDIAF---------RQKLLETRTE---------------EEFKEALVH 327
Cdd:TIGR00834 220 VRFLFVLLGPsgPGKDYH----EIGRAIATLMSDEVFhdaayladdRDDLLAGIDEfldcsivlppgewdpEIRLEPPAP 295

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217336345 328 -QRQLL-------TMVSHGPVAPRTKERSTVSLPAHRHPEPPKCKDFVPFGKGIReDIARRFPLYPLDFTDGIigkNKAV 399
Cdd:TIGR00834 296 lQRELLrkryepsTVRPENPTMGGDTEPEDGGSEGPHGDDDPLQRTGRPFGGLIR-DIKRRYPHYLSDFTDAL---NPQC 371

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2217336345 400 gkyITTTLFLYFACLLPTIAFGSLNDENTDGAIDVQKTIAGQSIGGLLYALFSGQPL 456
Cdd:TIGR00834 372 ---LAAVIFIYFAALSPAITFGGLLGEKTRNMMGVSELLISTAVQGVLFALLAAQPL 425
PtsN COG1762
Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type) [Carbohydrate ...
 249-327 1.57e-05

Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type) [Carbohydrate transport and metabolism, Signal transduction mechanisms];


Pssm-ID: 441368 [Multi-domain]  Cd Length: 150  Bit Score: 44.84  E-value: 1.57e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217336345 249 KALQKRHVCISRLVRPQNWGENSCE-VRFVILVLAPPKmkSTKTAMEVARTFATMFSDIAFRQKLLETRTEEEFKEALVH 327
Cdd:COG1762    71 EGVKKPGIAVARLKEPVDFGAMDGEpVDLVFLLAAPED--DSEEHLKLLAELARLLSDEEFREKLLNAKSPEEILELLKE 148
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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