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Conserved domains on  [gi|1039736202|ref|XP_017169851|]
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nuclear receptor corepressor 1 isoform X8 [Mus musculus]

Protein Classification

nuclear receptor corepressor 1( domain architecture ID 15502538)

nuclear receptor corepressor 1 (NCOR1) is a transcriptional coregulatory protein which assists nuclear receptors in the down regulation of gene expression

CATH:  1.20.58.1880
Gene Ontology:  GO:0006355|GO:0003700|GO:0003677
PubMed:  8882580|20084085
SCOP:  4000317

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GPS2_interact super family cl24372
G-protein pathway suppressor 2-interacting domain; GPS2_interact is the more N-terminal domain ...
 150-239 9.60e-27

G-protein pathway suppressor 2-interacting domain; GPS2_interact is the more N-terminal domain of two co-repressor protein-families found in vertebrates. The domain is found in NCoR and SMRT proteins; N-CoR (nuclear receptor co-repressor) and SMRT (silencing mediator for retinoid and thyroid receptors) are related corepressors that mediate transcriptional repression by unliganded nuclear receptors and other classes of transcriptional repressors. GPS2 is a stoichiometric subunit of the N-CoR-HDAC3 complex. GPS2 links the complex to membrane receptor-related intracellular JNK (c-Jun amino-terminal kinase) signalling pathways.


The actual alignment was detected with superfamily member pfam15784:

Pssm-ID: 464868 [Multi-domain]  Cd Length: 89  Bit Score: 105.71  E-value: 9.60e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736202  150 FGSKHEAPSSPLAGqPCGDDQNASPSKLSKEELIQSMDRVDREIAKVEQQILKLKKKQQQLEEEAAKPPEPEKPVSPPPV 229
Cdd:pfam15784    1 YYPQVEAISPTLPS-PEGQDQELSPFRSSKDELLQNIDKVDREIAKVEQQISKLKKKQQQLEEEAAKPPEPEEPVSPPPS 79

                           90
                   ....*....|
gi 1039736202  230 EQKHRSIVQI 239
Cdd:pfam15784   80 ESKHRSLAQI 89
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 628-671 6.37e-12

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


:

Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 62.14  E-value: 6.37e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1039736202  628 RWTEEEMEVAKKGLVEHGRNWAAIAKMVGTKSEAQCKNFYFNYK 671
Cdd:pfam00249    3 PWTPEEDELLLEAVEKLGNRWKKIAKLLPGRTDNQCKNRWQNYL 46
MDN1 super family cl34967
Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal ...
 718-917 7.85e-06

Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis];


The actual alignment was detected with superfamily member COG5271:

Pssm-ID: 444083 [Multi-domain]  Cd Length: 1028  Bit Score: 51.55  E-value: 7.85e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736202  718 DEDIEASNEEENPEDSEGAENSSDTESAPSPSPVEAAKSSEDSSENAASRGNTEPVAE------LEATTDPAPcASPSSA 791
Cdd:COG5271    454 DEEEEAEAELDTEEDTESAEEDADGDEATDEDDASDDGDEEEAEEDAEAEADSDELTAeetsadDGADTDAAA-DPEDSD 532

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736202  792 VPTTKPAERESVEAQVTDSASAETAEPMDVDHEECGAEGSS-VLDPPAPTKADSVDPEMQvpENTASKGEGDAKERDLES 870
Cdd:COG5271    533 EDALEDETEGEENAPGSDQDADETDEPEATAEEDEPDEAEAeTEDATENADADETEESAD--ESEEAEASEDEAAEEEEA 610

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1039736202  871 TSEKTEArDEDVVVAEQIERPEPQSDDDSS----ATCSADEGVDGEPERQR 917
Cdd:COG5271    611 DDDEADA-DADGAADEEETEEEAAEDEAAEpetdASEAADEDADAETEAEA 660
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 441-483 1.31e-04

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


:

Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 41.41  E-value: 1.31e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1039736202  441 WTDHEKEIFKDKFIQHP-KNFGLIASYLERKSVPDCVLYYYLTK 483
Cdd:cd00167      2 WTEEEDELLLEAVKKYGkNNWEKIAKELPGRTPKQCRERWRNLL 45
 
Name Accession Description Interval E-value
GPS2_interact pfam15784
G-protein pathway suppressor 2-interacting domain; GPS2_interact is the more N-terminal domain ...
 150-239 9.60e-27

G-protein pathway suppressor 2-interacting domain; GPS2_interact is the more N-terminal domain of two co-repressor protein-families found in vertebrates. The domain is found in NCoR and SMRT proteins; N-CoR (nuclear receptor co-repressor) and SMRT (silencing mediator for retinoid and thyroid receptors) are related corepressors that mediate transcriptional repression by unliganded nuclear receptors and other classes of transcriptional repressors. GPS2 is a stoichiometric subunit of the N-CoR-HDAC3 complex. GPS2 links the complex to membrane receptor-related intracellular JNK (c-Jun amino-terminal kinase) signalling pathways.


Pssm-ID: 464868 [Multi-domain]  Cd Length: 89  Bit Score: 105.71  E-value: 9.60e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736202  150 FGSKHEAPSSPLAGqPCGDDQNASPSKLSKEELIQSMDRVDREIAKVEQQILKLKKKQQQLEEEAAKPPEPEKPVSPPPV 229
Cdd:pfam15784    1 YYPQVEAISPTLPS-PEGQDQELSPFRSSKDELLQNIDKVDREIAKVEQQISKLKKKQQQLEEEAAKPPEPEEPVSPPPS 79

                           90
                   ....*....|
gi 1039736202  230 EQKHRSIVQI 239
Cdd:pfam15784   80 ESKHRSLAQI 89
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 628-671 6.37e-12

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 62.14  E-value: 6.37e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1039736202  628 RWTEEEMEVAKKGLVEHGRNWAAIAKMVGTKSEAQCKNFYFNYK 671
Cdd:pfam00249    3 PWTPEEDELLLEAVEKLGNRWKKIAKLLPGRTDNQCKNRWQNYL 46
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 628-671 1.38e-10

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 58.36  E-value: 1.38e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 1039736202  628 RWTEEEMEVAKKGLVEHG-RNWAAIAKMVGTKSEAQCKNFYFNYK 671
Cdd:cd00167      1 PWTEEEDELLLEAVKKYGkNNWEKIAKELPGRTPKQCRERWRNLL 45
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
628-673 2.19e-10

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 58.00  E-value: 2.19e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*..
gi 1039736202   628 RWTEEEMEVAKKGLVEHG-RNWAAIAKMVGTKSEAQCKNFYFNYKRR 673
Cdd:smart00717    3 EWTEEEDELLIELVKKYGkNNWEKIAKELPGRTAEQCRERWRNLLKP 49
MDN1 COG5271
Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal ...
 718-917 7.85e-06

Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444083 [Multi-domain]  Cd Length: 1028  Bit Score: 51.55  E-value: 7.85e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736202  718 DEDIEASNEEENPEDSEGAENSSDTESAPSPSPVEAAKSSEDSSENAASRGNTEPVAE------LEATTDPAPcASPSSA 791
Cdd:COG5271    454 DEEEEAEAELDTEEDTESAEEDADGDEATDEDDASDDGDEEEAEEDAEAEADSDELTAeetsadDGADTDAAA-DPEDSD 532

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736202  792 VPTTKPAERESVEAQVTDSASAETAEPMDVDHEECGAEGSS-VLDPPAPTKADSVDPEMQvpENTASKGEGDAKERDLES 870
Cdd:COG5271    533 EDALEDETEGEENAPGSDQDADETDEPEATAEEDEPDEAEAeTEDATENADADETEESAD--ESEEAEASEDEAAEEEEA 610

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1039736202  871 TSEKTEArDEDVVVAEQIERPEPQSDDDSS----ATCSADEGVDGEPERQR 917
Cdd:COG5271    611 DDDEADA-DADGAADEEETEEEAAEDEAAEpetdASEAADEDADAETEAEA 660
PRK13108 PRK13108
prolipoprotein diacylglyceryl transferase; Reviewed
 752-917 7.63e-05

prolipoprotein diacylglyceryl transferase; Reviewed


Pssm-ID: 237284 [Multi-domain]  Cd Length: 460  Bit Score: 48.05  E-value: 7.63e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736202  752 EAAKSSEDSSENAASRGNTEPVAELEATT--DPAPCASPSSAVPTTKPAERESVEAQVTDSASAETAEPMDVDHEEcGAE 829
Cdd:PRK13108   283 GALRGSEYVVDEALEREPAELAAAAVASAasAVGPVGPGEPNQPDDVAEAVKAEVAEVTDEVAAESVVQVADRDGE-STP 361

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736202  830 GSSVLDPPAPTKADSVDPEMQVPENTASKGEGDAKErDLESTSEKTEARDEDVVVAEQIERPEPQSDDDSSATCSADEGV 909
Cdd:PRK13108   362 AVEETSEADIEREQPGDLAGQAPAAHQVDAEAASAA-PEEPAALASEAHDETEPEVPEKAAPIPDPAKPDELAVAGPGDD 440


                   ....*...
gi 1039736202  910 DGEPERQR 917
Cdd:PRK13108   441 PAEPDGIR 448
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 441-483 1.31e-04

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 41.41  E-value: 1.31e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1039736202  441 WTDHEKEIFKDKFIQHP-KNFGLIASYLERKSVPDCVLYYYLTK 483
Cdd:cd00167      2 WTEEEDELLLEAVKKYGkNNWEKIAKELPGRTPKQCRERWRNLL 45
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
439-484 4.06e-04

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 40.28  E-value: 4.06e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*..
gi 1039736202   439 NVWTDHEKEIFKDKFIQHP-KNFGLIASYLERKSVPDCVLYYYLTKK 484
Cdd:smart00717    2 GEWTEEEDELLIELVKKYGkNNWEKIAKELPGRTAEQCRERWRNLLK 48
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 441-480 5.39e-04

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 39.79  E-value: 5.39e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1039736202  441 WTDHEKEIFKDKFIQHPKNFGLIASYLERKSVPDCVLYYY 480
Cdd:pfam00249    4 WTPEEDELLLEAVEKLGNRWKKIAKLLPGRTDNQCKNRWQ 43
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 684-912 7.59e-03

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 41.90  E-value: 7.59e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736202  684 KQKVSRAVVASRKPREE---RDVSQCESVAStvSAQEDEDIEASNEEENPEDSEG-AENSSDTES---APSPSPVEAAKS 756
Cdd:TIGR00927  613 KEQLSRRPVAKVMALGDlskGDVAEAEHTGE--RTGEEGERPTEAEGENGEESGGeAEQEGETETkgeNESEGEIPAERK 690

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736202  757 SEDSSENAASRGNTEPVAELEATTDPAPCASPSSAVPTTKPAERESVEAQVTDSASAETAEPMDVDHEECGAEGSSVLDP 836
Cdd:TIGR00927  691 GEQEGEGEIEAKEADHKGETEAEEVEHEGETEAEGTEDEGEIETGEEGEEVEDEGEGEAEGKHEVETEGDRKETEHEGET 770

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736202  837 PAPTKADSVDPEMQVPENTASKGEGDAKERDLESTSEKTEARDEDVVVAEQIERPEPQSDDDSSATCSAD---------E 907
Cdd:TIGR00927  771 EAEGKEDEDEGEIQAGEDGEMKGDEGAEGKVEHEGETEAGEKDEHEGQSETQADDTEVKDETGEQELNAEnqgeakqdeK 850


                   ....*
gi 1039736202  908 GVDGE 912
Cdd:TIGR00927  851 GVDGG 855
 
Name Accession Description Interval E-value
GPS2_interact pfam15784
G-protein pathway suppressor 2-interacting domain; GPS2_interact is the more N-terminal domain ...
 150-239 9.60e-27

G-protein pathway suppressor 2-interacting domain; GPS2_interact is the more N-terminal domain of two co-repressor protein-families found in vertebrates. The domain is found in NCoR and SMRT proteins; N-CoR (nuclear receptor co-repressor) and SMRT (silencing mediator for retinoid and thyroid receptors) are related corepressors that mediate transcriptional repression by unliganded nuclear receptors and other classes of transcriptional repressors. GPS2 is a stoichiometric subunit of the N-CoR-HDAC3 complex. GPS2 links the complex to membrane receptor-related intracellular JNK (c-Jun amino-terminal kinase) signalling pathways.


Pssm-ID: 464868 [Multi-domain]  Cd Length: 89  Bit Score: 105.71  E-value: 9.60e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736202  150 FGSKHEAPSSPLAGqPCGDDQNASPSKLSKEELIQSMDRVDREIAKVEQQILKLKKKQQQLEEEAAKPPEPEKPVSPPPV 229
Cdd:pfam15784    1 YYPQVEAISPTLPS-PEGQDQELSPFRSSKDELLQNIDKVDREIAKVEQQISKLKKKQQQLEEEAAKPPEPEEPVSPPPS 79

                           90
                   ....*....|
gi 1039736202  230 EQKHRSIVQI 239
Cdd:pfam15784   80 ESKHRSLAQI 89
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 628-671 6.37e-12

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 62.14  E-value: 6.37e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1039736202  628 RWTEEEMEVAKKGLVEHGRNWAAIAKMVGTKSEAQCKNFYFNYK 671
Cdd:pfam00249    3 PWTPEEDELLLEAVEKLGNRWKKIAKLLPGRTDNQCKNRWQNYL 46
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 628-671 1.38e-10

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 58.36  E-value: 1.38e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 1039736202  628 RWTEEEMEVAKKGLVEHG-RNWAAIAKMVGTKSEAQCKNFYFNYK 671
Cdd:cd00167      1 PWTEEEDELLLEAVKKYGkNNWEKIAKELPGRTPKQCRERWRNLL 45
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
628-673 2.19e-10

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 58.00  E-value: 2.19e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*..
gi 1039736202   628 RWTEEEMEVAKKGLVEHG-RNWAAIAKMVGTKSEAQCKNFYFNYKRR 673
Cdd:smart00717    3 EWTEEEDELLIELVKKYGkNNWEKIAKELPGRTAEQCRERWRNLLKP 49
MDN1 COG5271
Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal ...
 718-917 7.85e-06

Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444083 [Multi-domain]  Cd Length: 1028  Bit Score: 51.55  E-value: 7.85e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736202  718 DEDIEASNEEENPEDSEGAENSSDTESAPSPSPVEAAKSSEDSSENAASRGNTEPVAE------LEATTDPAPcASPSSA 791
Cdd:COG5271    454 DEEEEAEAELDTEEDTESAEEDADGDEATDEDDASDDGDEEEAEEDAEAEADSDELTAeetsadDGADTDAAA-DPEDSD 532

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736202  792 VPTTKPAERESVEAQVTDSASAETAEPMDVDHEECGAEGSS-VLDPPAPTKADSVDPEMQvpENTASKGEGDAKERDLES 870
Cdd:COG5271    533 EDALEDETEGEENAPGSDQDADETDEPEATAEEDEPDEAEAeTEDATENADADETEESAD--ESEEAEASEDEAAEEEEA 610

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1039736202  871 TSEKTEArDEDVVVAEQIERPEPQSDDDSS----ATCSADEGVDGEPERQR 917
Cdd:COG5271    611 DDDEADA-DADGAADEEETEEEAAEDEAAEpetdASEAADEDADAETEAEA 660
MDN1 COG5271
Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal ...
 693-912 4.25e-05

Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444083 [Multi-domain]  Cd Length: 1028  Bit Score: 49.24  E-value: 4.25e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736202  693 ASRKPREERDVSQCESVASTVSAQEDEDIEAS-----NEEENPEDSEGAENSSDTE------SAPSPSPVEAAKSSEDSS 761
Cdd:COG5271    525 AADPEDSDEDALEDETEGEENAPGSDQDADETdepeaTAEEDEPDEAEAETEDATEnadadeTEESADESEEAEASEDEA 604

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736202  762 ENAASRGNTEPVAELEATTDPAPCASPSSAVPTTKP------AERESVEAQVTDSASAETAEPMDVDHEECGAEGSSVL- 834
Cdd:COG5271    605 AEEEEADDDEADADADGAADEEETEEEAAEDEAAEPetdaseAADEDADAETEAEASADESEEEAEDESETSSEDAEEDa 684

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736202  835 -DPPAPTKADSVDPEM---------QVPENTASKGEGDAKERDLESTSEKTEARDE---------DVVVAEQIERPEPQS 895
Cdd:COG5271    685 dAAAAEASDDEEETEEadedaetasEEADAEEADTEADGTAEEAEEAAEEAESADEeaaslpdeaDAEEEAEEAEEAEED 764

                          250
                   ....*....|....*..
gi 1039736202  896 DDDSSATCSADEGVDGE 912
Cdd:COG5271    765 DADGLEEALEEEKADAE 781
PRK13108 PRK13108
prolipoprotein diacylglyceryl transferase; Reviewed
 752-917 7.63e-05

prolipoprotein diacylglyceryl transferase; Reviewed


Pssm-ID: 237284 [Multi-domain]  Cd Length: 460  Bit Score: 48.05  E-value: 7.63e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736202  752 EAAKSSEDSSENAASRGNTEPVAELEATT--DPAPCASPSSAVPTTKPAERESVEAQVTDSASAETAEPMDVDHEEcGAE 829
Cdd:PRK13108   283 GALRGSEYVVDEALEREPAELAAAAVASAasAVGPVGPGEPNQPDDVAEAVKAEVAEVTDEVAAESVVQVADRDGE-STP 361

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736202  830 GSSVLDPPAPTKADSVDPEMQVPENTASKGEGDAKErDLESTSEKTEARDEDVVVAEQIERPEPQSDDDSSATCSADEGV 909
Cdd:PRK13108   362 AVEETSEADIEREQPGDLAGQAPAAHQVDAEAASAA-PEEPAALASEAHDETEPEVPEKAAPIPDPAKPDELAVAGPGDD 440


                   ....*...
gi 1039736202  910 DGEPERQR 917
Cdd:PRK13108   441 PAEPDGIR 448
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 441-483 1.31e-04

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 41.41  E-value: 1.31e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1039736202  441 WTDHEKEIFKDKFIQHP-KNFGLIASYLERKSVPDCVLYYYLTK 483
Cdd:cd00167      2 WTEEEDELLLEAVKKYGkNNWEKIAKELPGRTPKQCRERWRNLL 45
MDN1 COG5271
Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal ...
 707-914 2.61e-04

Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444083 [Multi-domain]  Cd Length: 1028  Bit Score: 46.55  E-value: 2.61e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736202  707 ESVASTVSAQEDEDIEASNEEENPEDSEGAENSSDTESAPSPSPVEAAKSSEDSSENAASRGNTEPVAELEATTDPApcA 786
Cdd:COG5271    561 ATAEEDEPDEAEAETEDATENADADETEESADESEEAEASEDEAAEEEEADDDEADADADGAADEEETEEEAAEDEA--A 638

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736202  787 SPSSAVPTtkpAERESVEAQVTDSASAETAEPMDVDHEEcgaegssVLDPPAPTKADSVDPEMQVPENTASKGEGDAKER 866
Cdd:COG5271    639 EPETDASE---AADEDADAETEAEASADESEEEAEDESE-------TSSEDAEEDADAAAAEASDDEEETEEADEDAETA 708

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*...
gi 1039736202  867 DLESTSEKTEArDEDVVVAEQIERPEPQSDDDSSATcSADEGVDGEPE 914
Cdd:COG5271    709 SEEADAEEADT-EADGTAEEAEEAAEEAESADEEAA-SLPDEADAEEE 754
PRK13108 PRK13108
prolipoprotein diacylglyceryl transferase; Reviewed
 721-877 3.67e-04

prolipoprotein diacylglyceryl transferase; Reviewed


Pssm-ID: 237284 [Multi-domain]  Cd Length: 460  Bit Score: 45.74  E-value: 3.67e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736202  721 IEASNEEENPEDSEGAENSSDTESAPSPSPVEAAKSSEDSSENAASRGNT------------EPVAELEATTDPAPCASP 788
Cdd:PRK13108   273 ILAPKGREAPGALRGSEYVVDEALEREPAELAAAAVASAASAVGPVGPGEpnqpddvaeavkAEVAEVTDEVAAESVVQV 352

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736202  789 SSAVPTTKPAERESVEAQVTDSASAET-AEPMDVDHEECGAEGSSVLDPPAPTKADSVDPEMQVPENTASKGEGDakeRD 867
Cdd:PRK13108   353 ADRDGESTPAVEETSEADIEREQPGDLaGQAPAAHQVDAEAASAAPEEPAALASEAHDETEPEVPEKAAPIPDPA---KP 429

                          170
                   ....*....|
gi 1039736202  868 LESTSEKTEA 877
Cdd:PRK13108   430 DELAVAGPGD 439
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
439-484 4.06e-04

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 40.28  E-value: 4.06e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*..
gi 1039736202   439 NVWTDHEKEIFKDKFIQHP-KNFGLIASYLERKSVPDCVLYYYLTKK 484
Cdd:smart00717    2 GEWTEEEDELLIELVKKYGkNNWEKIAKELPGRTAEQCRERWRNLLK 48
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 441-480 5.39e-04

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 39.79  E-value: 5.39e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1039736202  441 WTDHEKEIFKDKFIQHPKNFGLIASYLERKSVPDCVLYYY 480
Cdd:pfam00249    4 WTPEEDELLLEAVEKLGNRWKKIAKLLPGRTDNQCKNRWQ 43
SANT_MTA3_like cd11661
Myb-Like Dna-Binding Domain of MTA3 and related proteins; Members in this SANT/myb family ...
 441-484 9.95e-04

Myb-Like Dna-Binding Domain of MTA3 and related proteins; Members in this SANT/myb family include domains found in mouse metastasis-associated protein 3 (MTA3) proteins and arginine-glutamic dipeptide (RERE) repeats proteins. SANT (SWI3, ADA2, N-CoR and TFIIIB) DNA-binding domains are a diverse set of proteins that share a common 3 alpha-helix bundle. MTA3 has been shown to interact with nucleosome remodeling and deacetylase (NuRD) proteins CHD4 and HDAC1, and the core cohesin complex protein RAD21 in the ovary, and regulate G2/M progression in proliferating granulosa cells. RERE belongs to the atrophin family and has been identified as a nuclear receptor corepressor; altered expression levels of RERE are associated with cancer in humans while mutations of Rere in mice cause failure in closing the anterior neural tube and fusion of the telencephalic and optic vesicles during embryogenesis.


Pssm-ID: 212559 [Multi-domain]  Cd Length: 46  Bit Score: 39.13  E-value: 9.95e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 1039736202  441 WTDHEKEIFKDKFIQHPKNFGLI-ASYLERKSVPDCVLYYYLTKK 484
Cdd:cd11661      2 WSESEAKLFEEGLRKYGKDFHDIrQDFLPWKSVGELVEFYYMWKK 46
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 733-933 1.04e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 44.78  E-value: 1.04e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736202  733 SEGAENSSDTESAPSPSPVEAAKSSEDSS----------------ENAASRGNTEPVAELEATTDPAPCA-SPSSAVPTT 795
Cdd:PHA03307    58 GAAACDRFEPPTGPPPGPGTEAPANESRStptwslstlapasparEGSPTPPGPSSPDPPPPTPPPASPPpSPAPDLSEM 137

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736202  796 KPAERESVEAQVTDSASAETAEPMDVDHEECGAEGSSVLDPPAPTKADSVDPEMQVPENT-ASKGEGDAKERDLESTSek 874
Cdd:PHA03307   138 LRPVGSPGPPPAASPPAAGASPAAVASDAASSRQAALPLSSPEETARAPSSPPAEPPPSTpPAAASPRPPRRSSPISA-- 215

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1039736202  875 tEARDEDVVVAEQIERPEPQSDDDSSATCSADEGVDGEPERQRvfPMDAKPSLLTPPGS 933
Cdd:PHA03307   216 -SASSPAPAPGRSAADDAGASSSDSSSSESSGCGWGPENECPL--PRPAPITLPTRIWE 271
MDN1 COG5271
Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal ...
 712-914 1.73e-03

Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444083 [Multi-domain]  Cd Length: 1028  Bit Score: 43.85  E-value: 1.73e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736202  712 TVSAQEDEDIEASNEEENPEDSEGAENSSDTESAPSPSPVEAAKSSEDSSENAASRGNTEPVAELEATTDPAPCASPSSA 791
Cdd:COG5271    266 GTPDTDDEATDDADGLEAAEDDALDAELTAAQAADPESDDDADDSTLAALEGAAEDTEIATADELAAADDEDDDDSAAED 345

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736202  792 VPTTKPAERESVEAQVTDSASAETAEPMDVDHEECGAEGSSVLDPPAPTKADSVDPEMQVPENTASKGEGDAKERDLEST 871
Cdd:COG5271    346 AAEEAATAEDSAAEDTQDAEDEAAGEAADESEGADTDAAADEADAAADDSADDEEASADGGTSPTSDTDEEEEEADEDAS 425

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|...
gi 1039736202  872 SEKTEARDEDVVVAEQIErpepqsDDDSSATCSADEGVDGEPE 914
Cdd:COG5271    426 AGETEDESTDVTSAEDDI------ATDEEADSLADEEEEAEAE 462
PHA03169 PHA03169
hypothetical protein; Provisional
 681-881 2.22e-03

hypothetical protein; Provisional


Pssm-ID: 223003 [Multi-domain]  Cd Length: 413  Bit Score: 43.04  E-value: 2.22e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736202  681 QQHKQKVSRAVVASRKPREERDVS-----QCESVASTVSAQEDEDIEASNEE---ENPEDSEGAENSSDTESAPSPSPVE 752
Cdd:PHA03169    28 GTREQAGRRRGTAARAAKPAPPAPttsgpQVRAVAEQGHRQTESDTETAEESrhgEKEERGQGGPSGSGSESVGSPTPSP 107

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736202  753 AAKSSEDSS----ENAASRGNTEPVAELEATTDPAPCASPSSAVPTT---KPAERESVEAQVTDSASAETAEPMDVDHEE 825
Cdd:PHA03169   108 SGSAEELASglspENTSGSSPESPASHSPPPSPPSHPGPHEPAPPEShnpSPNQQPSSFLQPSHEDSPEEPEPPTSEPEP 187

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1039736202  826 CGAEGSSVLDP-PAPTKADSVDPEMQVPENTASKGEGDAKERDLESTSEKTEARDED 881
Cdd:PHA03169   188 DSPGPPQSETPtSSPPPQSPPDEPGEPQSPTPQQAPSPNTQQAVEHEDEPTEPEREG 244
PRK08691 PRK08691
DNA polymerase III subunits gamma and tau; Validated
 693-865 2.25e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236333 [Multi-domain]  Cd Length: 709  Bit Score: 43.54  E-value: 2.25e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736202  693 ASRKPREERDVSQCESVASTVSAQ----EDEDIEASNEEENPEDSEGAENSSDTESAPSPSP-----VEAAKSSEDSSEN 763
Cdd:PRK08691   390 AAKKPQPRPEAETAQTPVQTASAAampsEGKTAGPVSNQENNDVPPWEDAPDEAQTAAGTAQtsaksIQTASEAETPPEN 469

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736202  764 AASRgNTEPVAELEATTDPAPCASPSSAVPTTKPAERESVEAQVTDSASAETAEPMDVDHEECGAEgssvlDPPAPTkad 843
Cdd:PRK08691   470 QVSK-NKAADNETDAPLSEVPSENPIQATPNDEAVETETFAHEAPAEPFYGYGFPDNDCPPEDGAE-----IPPPDW--- 540

                          170       180
                   ....*....|....*....|..
gi 1039736202  844 svdpEMQVPENTASKGEGDAKE 865
Cdd:PRK08691   541 ----EHAAPADTAGGGADEEAE 558
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 629-676 3.17e-03

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 38.06  E-value: 3.17e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 1039736202  629 WTEEEMEVAKKGLVEHGRNWAAIAKMVGTKSEAQCKnFYFNYKRRHNL 676
Cdd:pfam13921    1 WTEEEDEKLLKLVEKYGNDWKQIAKELGRRTPKQCF-DRWRRKLNPKI 47
PRK13108 PRK13108
prolipoprotein diacylglyceryl transferase; Reviewed
 751-914 3.71e-03

prolipoprotein diacylglyceryl transferase; Reviewed


Pssm-ID: 237284 [Multi-domain]  Cd Length: 460  Bit Score: 42.27  E-value: 3.71e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736202  751 VEAAKSSEDSsenAASRGNtEPVAELEATTDPAPCA-----SPSSAVPTTKPAEresvEAQVTDSASAETAEPMDVDHEE 825
Cdd:PRK13108   273 ILAPKGREAP---GALRGS-EYVVDEALEREPAELAaaavaSAASAVGPVGPGE----PNQPDDVAEAVKAEVAEVTDEV 344

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736202  826 CGAEGSSVLD-----PPAPTKADSVDPEMQVPENTASKGEGDAKERDLESTSEKTEARDEDVVVAEQIERPEPQSDDDSS 900
Cdd:PRK13108   345 AAESVVQVADrdgesTPAVEETSEADIEREQPGDLAGQAPAAHQVDAEAASAAPEEPAALASEAHDETEPEVPEKAAPIP 424

                          170
                   ....*....|....
gi 1039736202  901 ATCSADEGVDGEPE 914
Cdd:PRK13108   425 DPAKPDELAVAGPG 438
MDN1 COG5271
Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal ...
 714-914 5.35e-03

Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444083 [Multi-domain]  Cd Length: 1028  Bit Score: 42.31  E-value: 5.35e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736202  714 SAQEDEDIEASNEEENPED---------SEGAENSSDTEsapspSPVEAAKSSEDSSENAASRGNTEpvaelEATTDPAP 784
Cdd:COG5271    645 SEAADEDADAETEAEASADeseeeaedeSETSSEDAEED-----ADAAAAEASDDEEETEEADEDAE-----TASEEADA 714

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736202  785 CASPSSAVPTTKPAERESVEAQVTDSASAETAEPMDVDHEECGAEGSSVLDppAPTKADSVDPEMQVPENTASKGEGDAK 864
Cdd:COG5271    715 EEADTEADGTAEEAEEAAEEAESADEEAASLPDEADAEEEAEEAEEAEEDD--ADGLEEALEEEKADAEEAATDEEAEAA 792

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1039736202  865 ERDLESTSEKTEARDEDVVVAEQIE--------RPEPQSDDDSSATCSADEGVDGEPE 914
Cdd:COG5271    793 AEEKEKVADEDQDTDEDALLDEAEAdeeedldgEDEETADEALEDIEAGIAEDDEEDD 850
rne PRK10811
ribonuclease E; Reviewed
 692-858 5.53e-03

ribonuclease E; Reviewed


Pssm-ID: 236766 [Multi-domain]  Cd Length: 1068  Bit Score: 42.33  E-value: 5.53e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736202  692 VASRKPREERDVSQCESVASTVSAQEDEDIEASNEEENPEDSEGAENSSDTESAPSPSPVEAAKSSEDSSENAASRGNTE 771
Cdd:PRK10811   847 VVRPQDVQVEEQREAEEVQVQPVVAEVPVAAAVEPVVSAPVVEAVAEVVEEPVVVAEPQPEEVVVVETTHPEVIAAPVTE 926

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736202  772 PVAELEATTDPAPCASPSSAVPTTKPAERESVEAQVTDSASAETAEPMDVDHEECGAEGSSVLDPPAPTKADSVDPEMQV 851
Cdd:PRK10811   927 QPQVITESDVAVAQEVAEHAEPVVEPQDETADIEEAAETAEVVVAEPEVVAQPAAPVVAEVAAEVETVTAVEPEVAPAQV 1006


                   ....*..
gi 1039736202  852 PENTASK 858
Cdd:PRK10811  1007 PEATVEH 1013
PHA03169 PHA03169
hypothetical protein; Provisional
 671-917 6.29e-03

hypothetical protein; Provisional


Pssm-ID: 223003 [Multi-domain]  Cd Length: 413  Bit Score: 41.49  E-value: 6.29e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736202  671 KRRHNLDNLLQQH-KQKVSRAVVASRKPREERDVSQCESVASTVSAQEDEDIEASNEEENPEDSEGAENSSDTESAPSPS 749
Cdd:PHA03169    10 RSRHTLRSSCRGHcKRHGGTREQAGRRRGTAARAAKPAPPAPTTSGPQVRAVAEQGHRQTESDTETAEESRHGEKEERGQ 89

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736202  750 PVEAAKSSEDSSENAASRGNTEPV----AELEATTDPAPCASPSSAVPTTKPAERESVEaqvtdSASAETAEPMDVDHEE 825
Cdd:PHA03169    90 GGPSGSGSESVGSPTPSPSGSAEElasgLSPENTSGSSPESPASHSPPPSPPSHPGPHE-----PAPPESHNPSPNQQPS 164

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736202  826 CGAEGSSVLDPPAPTKADSVDPEmQVPENTASKGEGDAKERDLESTSEKTEARDEdvvvAEQIERPEPQSDDDSSATCSA 905
Cdd:PHA03169   165 SFLQPSHEDSPEEPEPPTSEPEP-DSPGPPQSETPTSSPPPQSPPDEPGEPQSPT----PQQAPSPNTQQAVEHEDEPTE 239

                          250
                   ....*....|..
gi 1039736202  906 DEGVDGEPERQR 917
Cdd:PHA03169   240 PEREGPPFPGHR 251
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 684-912 7.59e-03

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 41.90  E-value: 7.59e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736202  684 KQKVSRAVVASRKPREE---RDVSQCESVAStvSAQEDEDIEASNEEENPEDSEG-AENSSDTES---APSPSPVEAAKS 756
Cdd:TIGR00927  613 KEQLSRRPVAKVMALGDlskGDVAEAEHTGE--RTGEEGERPTEAEGENGEESGGeAEQEGETETkgeNESEGEIPAERK 690

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736202  757 SEDSSENAASRGNTEPVAELEATTDPAPCASPSSAVPTTKPAERESVEAQVTDSASAETAEPMDVDHEECGAEGSSVLDP 836
Cdd:TIGR00927  691 GEQEGEGEIEAKEADHKGETEAEEVEHEGETEAEGTEDEGEIETGEEGEEVEDEGEGEAEGKHEVETEGDRKETEHEGET 770

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736202  837 PAPTKADSVDPEMQVPENTASKGEGDAKERDLESTSEKTEARDEDVVVAEQIERPEPQSDDDSSATCSAD---------E 907
Cdd:TIGR00927  771 EAEGKEDEDEGEIQAGEDGEMKGDEGAEGKVEHEGETEAGEKDEHEGQSETQADDTEVKDETGEQELNAEnqgeakqdeK 850


                   ....*
gi 1039736202  908 GVDGE 912
Cdd:TIGR00927  851 GVDGG 855
MDN1 COG5271
Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal ...
 717-915 8.65e-03

Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444083 [Multi-domain]  Cd Length: 1028  Bit Score: 41.54  E-value: 8.65e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736202  717 EDEDIEASNEEENPEDSEGAENSSDTESAPSPSPVEAAKSSEDSSENAASRGNTEPVAELEATTDPAPCASPSSAVpttK 796
Cdd:COG5271    514 TSADDGADTDAAADPEDSDEDALEDETEGEENAPGSDQDADETDEPEATAEEDEPDEAEAETEDATENADADETEE---S 590

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736202  797 PAERESVEAQVTDSASAETAEPMDVDheecgAEGSSVLDppaptKADSVDPEMQVPENTASKGEGDAKERDLESTSEKTE 876
Cdd:COG5271    591 ADESEEAEASEDEAAEEEEADDDEAD-----ADADGAAD-----EEETEEEAAEDEAAEPETDASEAADEDADAETEAEA 660

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|
gi 1039736202  877 ARDEDVV-VAEQIERPEPQSDDDSSATcSADEGVDGEPER 915
Cdd:COG5271    661 SADESEEeAEDESETSSEDAEEDADAA-AAEASDDEEETE 699
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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