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Conserved domains on  [gi|1104498540|ref|XP_019073207|]
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putative disease resistance RPP13-like protein 1 isoform X2 [Vitis vinifera]

Protein Classification

NB-LRR family disease resistance protein( domain architecture ID 16059275)

NB-LRR family disease resistance protein guards the plant against pathogens via an indirect interaction with an avirulence protein contained in the plant, triggering a defense response that restricts the pathogen growth; similar to Oryza sativa Japonica Group disease resistance protein RGA4

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NB-ARC super family cl26397
NB-ARC domain;
181-334 1.80e-20

NB-ARC domain;


The actual alignment was detected with superfamily member pfam00931:

Pssm-ID: 395745 [Multi-domain]  Cd Length: 245  Bit Score: 88.98  E-value: 1.80e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104498540 181 QKEMMEWLLSDNTTGDKMGVMSIVGMGGSGKTTLARRLYND-EEVKKHFDLQAWVCVSTEFLLIKLTKTILEEIRspPTS 259
Cdd:pfam00931   1 REDMVEKVIGKLSEKDEPGIVGIHGMGGVGKTTLAAQIFNDfDEVEGHFDSVAWVVVSKTFTISTLQQTILQNLG--LSE 78

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1104498540 260 ADNLNLLQLQLKKQLSN----KKFLLVLDDVWNLKPRDEGYMELSDREgwnilqtpllaaaEGSKIVVTSRDQSVATTM 334
Cdd:pfam00931  79 DDWDNKEEGELARKIRRalltKRFLLVLDDVWDEEDWDKIGIPLPDRE-------------NGCRVLLTTRSEEVAGRV 144
Rx_N pfam18052
Rx N-terminal domain; This entry represents the N-terminal domain found in many plant ...
 5-92 3.24e-14

Rx N-terminal domain; This entry represents the N-terminal domain found in many plant resistance proteins. This domain has been predicted to be a coiled-coil, however the structure shows that it adopts a four helical bundle fold.


:

Pssm-ID: 436239  Cd Length: 93  Bit Score: 67.30  E-value: 3.24e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104498540   5 LLSASLQVLFQRLASPelinFIRRRNLSDELlSELKRKLVVVLNVLDDAEVKQFSNPNVKEWLVHVKGAVYDAEDLLDEI 84
Cdd:pfam18052   1 AVSSLLEKLGSLLAEE----AKLLKGVKDDL-EKLKDELESIQAFLEDAERKQITDEQVKLWLKQLRDVAYDAEDVLDEF 75


                  ....*...
gi 1104498540  85 ATDALRCK 92
Cdd:pfam18052  76 LYEALRRK 83
 
Name Accession Description Interval E-value
NB-ARC pfam00931
NB-ARC domain;
181-334 1.80e-20

NB-ARC domain;


Pssm-ID: 395745 [Multi-domain]  Cd Length: 245  Bit Score: 88.98  E-value: 1.80e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104498540 181 QKEMMEWLLSDNTTGDKMGVMSIVGMGGSGKTTLARRLYND-EEVKKHFDLQAWVCVSTEFLLIKLTKTILEEIRspPTS 259
Cdd:pfam00931   1 REDMVEKVIGKLSEKDEPGIVGIHGMGGVGKTTLAAQIFNDfDEVEGHFDSVAWVVVSKTFTISTLQQTILQNLG--LSE 78

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1104498540 260 ADNLNLLQLQLKKQLSN----KKFLLVLDDVWNLKPRDEGYMELSDREgwnilqtpllaaaEGSKIVVTSRDQSVATTM 334
Cdd:pfam00931  79 DDWDNKEEGELARKIRRalltKRFLLVLDDVWDEEDWDKIGIPLPDRE-------------NGCRVLLTTRSEEVAGRV 144
Rx_N pfam18052
Rx N-terminal domain; This entry represents the N-terminal domain found in many plant ...
 5-92 3.24e-14

Rx N-terminal domain; This entry represents the N-terminal domain found in many plant resistance proteins. This domain has been predicted to be a coiled-coil, however the structure shows that it adopts a four helical bundle fold.


Pssm-ID: 436239  Cd Length: 93  Bit Score: 67.30  E-value: 3.24e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104498540   5 LLSASLQVLFQRLASPelinFIRRRNLSDELlSELKRKLVVVLNVLDDAEVKQFSNPNVKEWLVHVKGAVYDAEDLLDEI 84
Cdd:pfam18052   1 AVSSLLEKLGSLLAEE----AKLLKGVKDDL-EKLKDELESIQAFLEDAERKQITDEQVKLWLKQLRDVAYDAEDVLDEF 75


                  ....*...
gi 1104498540  85 ATDALRCK 92
Cdd:pfam18052  76 LYEALRRK 83
RX-CC_like cd14798
Coiled-coil domain of the potato virux X resistance protein and similar proteins; The potato ...
 34-86 7.89e-05

Coiled-coil domain of the potato virux X resistance protein and similar proteins; The potato virus X resistance protein (RX) confers resistance against potato virus X. It is a member of a family of resistance proteins with a domain architecture that includes an N-terminal coiled-coil domain (modeled here), a nucleotide-binding domain, and leucine-rich repeats (CC-NB-LRR). These intracellular resistance proteins recognize pathogen effector proteins and will subsequently trigger a response that may be as severe as localized cell death. The N-terminal coiled-coil domain of RX has been shown to interact with RanGAP2, which is a necessary co-factor in the resistance response.


Pssm-ID: 271353 [Multi-domain]  Cd Length: 124  Bit Score: 41.84  E-value: 7.89e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1104498540  34 ELLSELKRKLVVVLNVLDDAEVKQFSNPNVKEWLVHVKGAVYDAEDLLDEIAT 86
Cdd:cd14798    28 EEIESLKDELESMQAFLKDADAKQDEDEELKDWVKQVRDVAYDAEDIIDSFLL 80
Gem1 COG1100
GTPase SAR1 family domain [General function prediction only];
203-222 3.83e-03

GTPase SAR1 family domain [General function prediction only];


Pssm-ID: 440717 [Multi-domain]  Cd Length: 177  Bit Score: 37.65  E-value: 3.83e-03
                          10        20
                  ....*....|....*....|
gi 1104498540 203 IVGMGGSGKTTLARRLYNDE 222
Cdd:COG1100     8 VVGTGGVGKTSLVNRLVGDI 27
 
Name Accession Description Interval E-value
NB-ARC pfam00931
NB-ARC domain;
181-334 1.80e-20

NB-ARC domain;


Pssm-ID: 395745 [Multi-domain]  Cd Length: 245  Bit Score: 88.98  E-value: 1.80e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104498540 181 QKEMMEWLLSDNTTGDKMGVMSIVGMGGSGKTTLARRLYND-EEVKKHFDLQAWVCVSTEFLLIKLTKTILEEIRspPTS 259
Cdd:pfam00931   1 REDMVEKVIGKLSEKDEPGIVGIHGMGGVGKTTLAAQIFNDfDEVEGHFDSVAWVVVSKTFTISTLQQTILQNLG--LSE 78

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1104498540 260 ADNLNLLQLQLKKQLSN----KKFLLVLDDVWNLKPRDEGYMELSDREgwnilqtpllaaaEGSKIVVTSRDQSVATTM 334
Cdd:pfam00931  79 DDWDNKEEGELARKIRRalltKRFLLVLDDVWDEEDWDKIGIPLPDRE-------------NGCRVLLTTRSEEVAGRV 144
Rx_N pfam18052
Rx N-terminal domain; This entry represents the N-terminal domain found in many plant ...
 5-92 3.24e-14

Rx N-terminal domain; This entry represents the N-terminal domain found in many plant resistance proteins. This domain has been predicted to be a coiled-coil, however the structure shows that it adopts a four helical bundle fold.


Pssm-ID: 436239  Cd Length: 93  Bit Score: 67.30  E-value: 3.24e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104498540   5 LLSASLQVLFQRLASPelinFIRRRNLSDELlSELKRKLVVVLNVLDDAEVKQFSNPNVKEWLVHVKGAVYDAEDLLDEI 84
Cdd:pfam18052   1 AVSSLLEKLGSLLAEE----AKLLKGVKDDL-EKLKDELESIQAFLEDAERKQITDEQVKLWLKQLRDVAYDAEDVLDEF 75


                  ....*...
gi 1104498540  85 ATDALRCK 92
Cdd:pfam18052  76 LYEALRRK 83
RX-CC_like cd14798
Coiled-coil domain of the potato virux X resistance protein and similar proteins; The potato ...
 34-86 7.89e-05

Coiled-coil domain of the potato virux X resistance protein and similar proteins; The potato virus X resistance protein (RX) confers resistance against potato virus X. It is a member of a family of resistance proteins with a domain architecture that includes an N-terminal coiled-coil domain (modeled here), a nucleotide-binding domain, and leucine-rich repeats (CC-NB-LRR). These intracellular resistance proteins recognize pathogen effector proteins and will subsequently trigger a response that may be as severe as localized cell death. The N-terminal coiled-coil domain of RX has been shown to interact with RanGAP2, which is a necessary co-factor in the resistance response.


Pssm-ID: 271353 [Multi-domain]  Cd Length: 124  Bit Score: 41.84  E-value: 7.89e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1104498540  34 ELLSELKRKLVVVLNVLDDAEVKQFSNPNVKEWLVHVKGAVYDAEDLLDEIAT 86
Cdd:cd14798    28 EEIESLKDELESMQAFLKDADAKQDEDEELKDWVKQVRDVAYDAEDIIDSFLL 80
Gem1 COG1100
GTPase SAR1 family domain [General function prediction only];
203-222 3.83e-03

GTPase SAR1 family domain [General function prediction only];


Pssm-ID: 440717 [Multi-domain]  Cd Length: 177  Bit Score: 37.65  E-value: 3.83e-03
                          10        20
                  ....*....|....*....|
gi 1104498540 203 IVGMGGSGKTTLARRLYNDE 222
Cdd:COG1100     8 VVGTGGVGKTSLVNRLVGDI 27
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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