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Conserved domains on  [gi|1201877459|ref|XP_021234930|]
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proliferation-associated protein 2G4 [Numida meleagris]

Protein Classification

crvDNA_42K family protein( domain architecture ID 10794573)

crvDNA_42K family protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
crvDNA_42K TIGR00495
42K curved DNA binding protein; Proteins identified by this model have been identified in a ...
 1-388 0e+00

42K curved DNA binding protein; Proteins identified by this model have been identified in a number of species as a nuclear (but not nucleolar) protein with a cell cycle dependence. Various names given to members of this family have included cell cycle protein p38-2G4, DNA-binding protein GBP16, and proliferation-associated protein 1. This protein is closely related to methionine aminopeptidase, a cobolt-binding protein. [Unknown function, General]


:

Pssm-ID: 273105  Cd Length: 390  Bit Score: 637.70  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201877459   1 MSGEEEA--AELTIAEDLVVTKYKMGGDIANRVLRAVVEEANSGASVLCLCEKGDAMIMEETGKIFKKEKEMKKGIAFPT 78
Cdd:TIGR00495   1 MSGKDEQqeQAYSLSNPEVVTKYKMAGEIANNVLKSVVEACSPGAKVVDICEKGDAFIMEETAKIFKKEKEMEKGIAFPT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201877459  79 SISVNNCVCHFSPLKSDQDYILKDGDLVKIDLGVHVDGFIANVAHSFVIDASKENPVSGRKADVIKAAHLCAEAALRLVK 158
Cdd:TIGR00495  81 CISVNNCVGHFSPLKSDQDYILKEGDVVKIDLGCHIDGFIALVAHTFVVGVAQEEPVTGRKADVIAAAHLAAEAALRLVK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201877459 159 PGNQNTQVTDAWNKIAHSFHCTPIEGMLSHQLKQHVIDGEKTIIQNPTDQQKKDHEKAEFEVHEVYAVDVLVSSGEGKAK 238
Cdd:TIGR00495 161 PGNTNTQVTEAINKVAHSYGCTPVEGMLSHQLKQHVIDGEKVIISNPSDSQKKDHDTAEFEENEVYAVDILVSTGEGKAK 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201877459 239 DAGQRTTIYKRDPSKQYGLKMKTSRAFFSEVERRFDTMPFTLRAFEDEKKARMGVVECAKHELLQPFNVLYEKEGEFVAQ 318
Cdd:TIGR00495 241 DADQRTTIYKRDPSKTYGLKMKASRAFFSEIERRFDAMPFTLRNFEDEKRARMGLVECVKHELLQPYPVLYEKEGEFVAQ 320

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201877459 319 FKFTVLLMPNGPMRITSGPFEPELYKSEFEVQDGELKALLQSSASRKTQKKKKKKASKNAENATTGETAE 388
Cdd:TIGR00495 321 FKFTVLLMPNGPMRITSGEFEPDLYKSEMEVQDPEIKALLASPIKRKKQKKKAKKASKTGEAATEGETME 390
 
Name Accession Description Interval E-value
crvDNA_42K TIGR00495
42K curved DNA binding protein; Proteins identified by this model have been identified in a ...
 1-388 0e+00

42K curved DNA binding protein; Proteins identified by this model have been identified in a number of species as a nuclear (but not nucleolar) protein with a cell cycle dependence. Various names given to members of this family have included cell cycle protein p38-2G4, DNA-binding protein GBP16, and proliferation-associated protein 1. This protein is closely related to methionine aminopeptidase, a cobolt-binding protein. [Unknown function, General]


Pssm-ID: 273105  Cd Length: 390  Bit Score: 637.70  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201877459   1 MSGEEEA--AELTIAEDLVVTKYKMGGDIANRVLRAVVEEANSGASVLCLCEKGDAMIMEETGKIFKKEKEMKKGIAFPT 78
Cdd:TIGR00495   1 MSGKDEQqeQAYSLSNPEVVTKYKMAGEIANNVLKSVVEACSPGAKVVDICEKGDAFIMEETAKIFKKEKEMEKGIAFPT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201877459  79 SISVNNCVCHFSPLKSDQDYILKDGDLVKIDLGVHVDGFIANVAHSFVIDASKENPVSGRKADVIKAAHLCAEAALRLVK 158
Cdd:TIGR00495  81 CISVNNCVGHFSPLKSDQDYILKEGDVVKIDLGCHIDGFIALVAHTFVVGVAQEEPVTGRKADVIAAAHLAAEAALRLVK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201877459 159 PGNQNTQVTDAWNKIAHSFHCTPIEGMLSHQLKQHVIDGEKTIIQNPTDQQKKDHEKAEFEVHEVYAVDVLVSSGEGKAK 238
Cdd:TIGR00495 161 PGNTNTQVTEAINKVAHSYGCTPVEGMLSHQLKQHVIDGEKVIISNPSDSQKKDHDTAEFEENEVYAVDILVSTGEGKAK 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201877459 239 DAGQRTTIYKRDPSKQYGLKMKTSRAFFSEVERRFDTMPFTLRAFEDEKKARMGVVECAKHELLQPFNVLYEKEGEFVAQ 318
Cdd:TIGR00495 241 DADQRTTIYKRDPSKTYGLKMKASRAFFSEIERRFDAMPFTLRNFEDEKRARMGLVECVKHELLQPYPVLYEKEGEFVAQ 320

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201877459 319 FKFTVLLMPNGPMRITSGPFEPELYKSEFEVQDGELKALLQSSASRKTQKKKKKKASKNAENATTGETAE 388
Cdd:TIGR00495 321 FKFTVLLMPNGPMRITSGEFEPDLYKSEMEVQDPEIKALLASPIKRKKQKKKAKKASKTGEAATEGETME 390
PA2G4-like cd01089
Related to aminopepdidase M, this family contains proliferation-associated protein 2G4. Family ...
 18-334 1.53e-122

Related to aminopepdidase M, this family contains proliferation-associated protein 2G4. Family members have been implicated in cell cycle control.


Pssm-ID: 238522  Cd Length: 228  Bit Score: 353.56  E-value: 1.53e-122
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201877459  18 VTKYKMGGDIANRVLRAVVEEANSGASVLCLCEKGDAMIMEETGKIFKKEKEMKKGIAFPTSISVNNCVCHFSPLKSDQD 97
Cdd:cd01089     1 VTKYKTAGQIANKVLKQVISLCVPGAKVVDLCEKGDKLILEELGKVYKKEKKLEKGIAFPTCISVNNCVCHFSPLKSDAT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201877459  98 YILKDGDLVKIDLGVHVDGFIANVAHSFVIDASKENPVSGRKADVIKAAHLCAEAALRLVKPGNQNTQVTDAWNKIAHSF 177
Cdd:cd01089    81 YTLKDGDVVKIDLGCHIDGYIAVVAHTIVVGAEAETPVTGKKADVIAAAHYALEAALRLLRPGNQNSDITEAIQKVIVDY 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201877459 178 HCTPIEGMLSHQLKQhvidgektiiqnptdqqkkdhekaefevhevyavdvLVSSGEGKAKdagqrttiykrdpskqygl 257
Cdd:cd01089   161 GCTPVEGVLSHQLKR------------------------------------VVSSGEGKAK------------------- 185

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1201877459 258 kmktsraffseverrfdtmpftlrafedekkarmgVVECAKHELLQPFNVLYEKEGEFVAQFKFTVLLMPNGPMRIT 334
Cdd:cd01089   186 -----------------------------------LVECVKHGLLFPYPVLYEKEGEVVAQFKLTVLLTPNGVTVLT 227
PTZ00053 PTZ00053
methionine aminopeptidase 2; Provisional
 42-329 1.17e-20

methionine aminopeptidase 2; Provisional


Pssm-ID: 240246 [Multi-domain]  Cd Length: 470  Bit Score: 93.24  E-value: 1.17e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201877459  42 GASVLCLCEKGDAMIMEETGkifkkEKEMKKGIAFPTSISVNNCVCHFSPLKSDqDYILKDGDLVKIDLGVHVDGFIANV 121
Cdd:PTZ00053  182 GVKLIDICERIESKSRELIE-----ADGLKCGWAFPTGCSLNHCAAHYTPNTGD-KTVLTYDDVCKLDFGTHVNGRIIDC 255

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201877459 122 AHSF--------VIDASKENPVSGrkadvIKAAHLCAeaalRLVKPGNQNTQVTDAW-----NKIahsFHCTPIEGMLSH 188
Cdd:PTZ00053  256 AFTVafnpkydpLLQATKDATNTG-----IKEAGIDV----RLSDIGAAIQEVIESYeveikGKT---YPIKSIRNLNGH 323

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201877459 189 QLKQHVIDGEKTI-IQNPTDQQKkdhekaeFEVHEVYAVDVLVSSGEGKAKDAGQrTTIYKRDPSKQYG-LKMKTSRAFF 266
Cdd:PTZ00053  324 SIGPYIIHGGKSVpIVKGGENTR-------MEEGELFAIETFASTGRGYVNEDLE-CSHYMKDPGAEFVpLRLPKAKQLL 395

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1201877459 267 SEVERRFDTMPFTLRAFED--EKKARMGVVECAKHELLQPFNVLYEKEGEFVAQFKFTVLLMPNG 329
Cdd:PTZ00053  396 KHINTNFGTLAFCRRWLDRlgQDRHLLALKQLVDAGIVNPYPPLCDVRGSYTSQMEHTILLRPTC 460
Peptidase_M24 pfam00557
Metallopeptidase family M24; This family contains metallopeptidases. It also contains ...
 25-174 2.90e-16

Metallopeptidase family M24; This family contains metallopeptidases. It also contains non-peptidase homologs such as the N terminal domain of Spt16 which is a histone H3-H4 binding module.


Pssm-ID: 459852 [Multi-domain]  Cd Length: 208  Bit Score: 76.90  E-value: 2.90e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201877459  25 GDIANRVLRAVVEEANSGASVLCLCEKGDAMIMEETGKifkkekemkKGIAFPTSI--SVNNCVCHFSPLksdqDYILKD 102
Cdd:pfam00557   7 ARIAAAALEAALAAIRPGVTERELAAELEAARLRRGGA---------RGPAFPPIVasGPNAAIPHYIPN----DRVLKP 73

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1201877459 103 GDLVKIDLGVHVD-GFIANVAHSFVIDaskenPVSGRKADVIKAAHLCAEAALRLVKPGNQNTQVTDAWNKIA 174
Cdd:pfam00557  74 GDLVLIDVGAEYDgGYCSDITRTFVVG-----KPSPEQRELYEAVLEAQEAAIAAVKPGVTGGDVDAAAREVL 141
Map COG0024
Methionine aminopeptidase [Translation, ribosomal structure and biogenesis];
76-161 1.62e-13

Methionine aminopeptidase [Translation, ribosomal structure and biogenesis];


Pssm-ID: 439795 [Multi-domain]  Cd Length: 250  Bit Score: 69.65  E-value: 1.62e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201877459  76 FPTSI--SVNNCVCHFSPlksdQDYILKDGDLVKIDLGVHVDGFIANVAHSFVIdaskeNPVSGRKADVIKAAHLCAEAA 153
Cdd:COG0024    62 FPKSIctSVNEVVVHGIP----SDRVLKDGDIVNIDVGAILDGYHGDSARTFVV-----GEVSPEARRLVEVTEEALYAG 132


                  ....*...
gi 1201877459 154 LRLVKPGN 161
Cdd:COG0024   133 IAAAKPGN 140
 
Name Accession Description Interval E-value
crvDNA_42K TIGR00495
42K curved DNA binding protein; Proteins identified by this model have been identified in a ...
 1-388 0e+00

42K curved DNA binding protein; Proteins identified by this model have been identified in a number of species as a nuclear (but not nucleolar) protein with a cell cycle dependence. Various names given to members of this family have included cell cycle protein p38-2G4, DNA-binding protein GBP16, and proliferation-associated protein 1. This protein is closely related to methionine aminopeptidase, a cobolt-binding protein. [Unknown function, General]


Pssm-ID: 273105  Cd Length: 390  Bit Score: 637.70  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201877459   1 MSGEEEA--AELTIAEDLVVTKYKMGGDIANRVLRAVVEEANSGASVLCLCEKGDAMIMEETGKIFKKEKEMKKGIAFPT 78
Cdd:TIGR00495   1 MSGKDEQqeQAYSLSNPEVVTKYKMAGEIANNVLKSVVEACSPGAKVVDICEKGDAFIMEETAKIFKKEKEMEKGIAFPT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201877459  79 SISVNNCVCHFSPLKSDQDYILKDGDLVKIDLGVHVDGFIANVAHSFVIDASKENPVSGRKADVIKAAHLCAEAALRLVK 158
Cdd:TIGR00495  81 CISVNNCVGHFSPLKSDQDYILKEGDVVKIDLGCHIDGFIALVAHTFVVGVAQEEPVTGRKADVIAAAHLAAEAALRLVK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201877459 159 PGNQNTQVTDAWNKIAHSFHCTPIEGMLSHQLKQHVIDGEKTIIQNPTDQQKKDHEKAEFEVHEVYAVDVLVSSGEGKAK 238
Cdd:TIGR00495 161 PGNTNTQVTEAINKVAHSYGCTPVEGMLSHQLKQHVIDGEKVIISNPSDSQKKDHDTAEFEENEVYAVDILVSTGEGKAK 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201877459 239 DAGQRTTIYKRDPSKQYGLKMKTSRAFFSEVERRFDTMPFTLRAFEDEKKARMGVVECAKHELLQPFNVLYEKEGEFVAQ 318
Cdd:TIGR00495 241 DADQRTTIYKRDPSKTYGLKMKASRAFFSEIERRFDAMPFTLRNFEDEKRARMGLVECVKHELLQPYPVLYEKEGEFVAQ 320

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201877459 319 FKFTVLLMPNGPMRITSGPFEPELYKSEFEVQDGELKALLQSSASRKTQKKKKKKASKNAENATTGETAE 388
Cdd:TIGR00495 321 FKFTVLLMPNGPMRITSGEFEPDLYKSEMEVQDPEIKALLASPIKRKKQKKKAKKASKTGEAATEGETME 390
PA2G4-like cd01089
Related to aminopepdidase M, this family contains proliferation-associated protein 2G4. Family ...
 18-334 1.53e-122

Related to aminopepdidase M, this family contains proliferation-associated protein 2G4. Family members have been implicated in cell cycle control.


Pssm-ID: 238522  Cd Length: 228  Bit Score: 353.56  E-value: 1.53e-122
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201877459  18 VTKYKMGGDIANRVLRAVVEEANSGASVLCLCEKGDAMIMEETGKIFKKEKEMKKGIAFPTSISVNNCVCHFSPLKSDQD 97
Cdd:cd01089     1 VTKYKTAGQIANKVLKQVISLCVPGAKVVDLCEKGDKLILEELGKVYKKEKKLEKGIAFPTCISVNNCVCHFSPLKSDAT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201877459  98 YILKDGDLVKIDLGVHVDGFIANVAHSFVIDASKENPVSGRKADVIKAAHLCAEAALRLVKPGNQNTQVTDAWNKIAHSF 177
Cdd:cd01089    81 YTLKDGDVVKIDLGCHIDGYIAVVAHTIVVGAEAETPVTGKKADVIAAAHYALEAALRLLRPGNQNSDITEAIQKVIVDY 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201877459 178 HCTPIEGMLSHQLKQhvidgektiiqnptdqqkkdhekaefevhevyavdvLVSSGEGKAKdagqrttiykrdpskqygl 257
Cdd:cd01089   161 GCTPVEGVLSHQLKR------------------------------------VVSSGEGKAK------------------- 185

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1201877459 258 kmktsraffseverrfdtmpftlrafedekkarmgVVECAKHELLQPFNVLYEKEGEFVAQFKFTVLLMPNGPMRIT 334
Cdd:cd01089   186 -----------------------------------LVECVKHGLLFPYPVLYEKEGEVVAQFKLTVLLTPNGVTVLT 227
MetAP2 cd01088
Methionine Aminopeptidase 2. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and ...
 20-329 1.21e-49

Methionine Aminopeptidase 2. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.


Pssm-ID: 238521 [Multi-domain]  Cd Length: 291  Bit Score: 168.97  E-value: 1.21e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201877459  20 KYKMGGDIANRVLRAVVEEANSGASVLCLCEKGDAMIMEETGkifkkekemkkGIAFPTSISVNNCVCHFSPLKSDqDYI 99
Cdd:cd01088     3 KYREAGEIHRQVRKYAQSLIKPGMTLLEIAEFVENRIRELGA-----------GPAFPVNLSINECAAHYTPNAGD-DTV 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201877459 100 LKDGDLVKIDLGVHVDGFIANVAhsFVIDaskenpVSGRKADVIKAAHLCAEAALRLVKPGNQNTQVTDAWNKIAHSFHC 179
Cdd:cd01088    71 LKEGDVVKLDFGAHVDGYIADSA--FTVD------FDPKYDDLLEAAKEALNAAIKEAGPDVRLGEIGEAIEEVIESYGF 142

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201877459 180 TPIEGMLSHQLKQHVIDGEKTIiqnPTDqqkKDHEKAEFEVHEVYAVDVLVSSGEGKAKDaGQRTTIYKRDPSKQYGLKM 259
Cdd:cd01088   143 KPIRNLTGHSIERYRLHAGKSI---PNV---KGGEGTRLEEGDVYAIEPFATTGKGYVHD-GPECSIYMLNRDKPLRLPR 215

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1201877459 260 ktSRAFFSEVERRFDTMPFTLRAFED--EKKARMGVVECAKHELLQPFNVLYEKEGEFVAQFKFTVLLMPNG 329
Cdd:cd01088   216 --ARKLLDVIYENFGTLPFARRWLDRlgETKLLMALKNLCKAGIVYPYPVLKEISGGYVAQFEHTIIVREDG 285
PTZ00053 PTZ00053
methionine aminopeptidase 2; Provisional
 42-329 1.17e-20

methionine aminopeptidase 2; Provisional


Pssm-ID: 240246 [Multi-domain]  Cd Length: 470  Bit Score: 93.24  E-value: 1.17e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201877459  42 GASVLCLCEKGDAMIMEETGkifkkEKEMKKGIAFPTSISVNNCVCHFSPLKSDqDYILKDGDLVKIDLGVHVDGFIANV 121
Cdd:PTZ00053  182 GVKLIDICERIESKSRELIE-----ADGLKCGWAFPTGCSLNHCAAHYTPNTGD-KTVLTYDDVCKLDFGTHVNGRIIDC 255

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201877459 122 AHSF--------VIDASKENPVSGrkadvIKAAHLCAeaalRLVKPGNQNTQVTDAW-----NKIahsFHCTPIEGMLSH 188
Cdd:PTZ00053  256 AFTVafnpkydpLLQATKDATNTG-----IKEAGIDV----RLSDIGAAIQEVIESYeveikGKT---YPIKSIRNLNGH 323

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201877459 189 QLKQHVIDGEKTI-IQNPTDQQKkdhekaeFEVHEVYAVDVLVSSGEGKAKDAGQrTTIYKRDPSKQYG-LKMKTSRAFF 266
Cdd:PTZ00053  324 SIGPYIIHGGKSVpIVKGGENTR-------MEEGELFAIETFASTGRGYVNEDLE-CSHYMKDPGAEFVpLRLPKAKQLL 395

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1201877459 267 SEVERRFDTMPFTLRAFED--EKKARMGVVECAKHELLQPFNVLYEKEGEFVAQFKFTVLLMPNG 329
Cdd:PTZ00053  396 KHINTNFGTLAFCRRWLDRlgQDRHLLALKQLVDAGIVNPYPPLCDVRGSYTSQMEHTILLRPTC 460
MetAP1 cd01086
Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and ...
 25-188 8.18e-17

Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.


Pssm-ID: 238519 [Multi-domain]  Cd Length: 238  Bit Score: 79.07  E-value: 8.18e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201877459  25 GDIANRVLRAVVEEANSGASVLCLCEKGDAMIMEETGKI-FKKEKemkkgiAFPTSI--SVNNCVCHFSPlksdQDYILK 101
Cdd:cd01086     8 GRIVAEVLDELAKAIKPGVTTKELDQIAHEFIEEHGAYPaPLGYY------GFPKSIctSVNEVVCHGIP----DDRVLK 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201877459 102 DGDLVKIDLGVHVDGFIANVAHSFVIdaskeNPVSGRKADVIKAAHLCAEAALRLVKPGNQNTQVTDAWNKIAHSFHCTP 181
Cdd:cd01086    78 DGDIVNIDVGVELDGYHGDSARTFIV-----GEVSEEAKKLVEVTEEALYKGIEAVKPGNRIGDIGHAIEKYAEKNGYSV 152


                  ....*..
gi 1201877459 182 IEGMLSH 188
Cdd:cd01086   153 VREFGGH 159
Peptidase_M24 pfam00557
Metallopeptidase family M24; This family contains metallopeptidases. It also contains ...
 25-174 2.90e-16

Metallopeptidase family M24; This family contains metallopeptidases. It also contains non-peptidase homologs such as the N terminal domain of Spt16 which is a histone H3-H4 binding module.


Pssm-ID: 459852 [Multi-domain]  Cd Length: 208  Bit Score: 76.90  E-value: 2.90e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201877459  25 GDIANRVLRAVVEEANSGASVLCLCEKGDAMIMEETGKifkkekemkKGIAFPTSI--SVNNCVCHFSPLksdqDYILKD 102
Cdd:pfam00557   7 ARIAAAALEAALAAIRPGVTERELAAELEAARLRRGGA---------RGPAFPPIVasGPNAAIPHYIPN----DRVLKP 73

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1201877459 103 GDLVKIDLGVHVD-GFIANVAHSFVIDaskenPVSGRKADVIKAAHLCAEAALRLVKPGNQNTQVTDAWNKIA 174
Cdd:pfam00557  74 GDLVLIDVGAEYDgGYCSDITRTFVVG-----KPSPEQRELYEAVLEAQEAAIAAVKPGVTGGDVDAAAREVL 141
APP_MetAP cd01066
A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as ...
 18-181 2.04e-14

A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity compared to other metallo-aminopeptidases, suggesting they play roles in regulation of biological processes rather than general protein degradation.


Pssm-ID: 238514 [Multi-domain]  Cd Length: 207  Bit Score: 71.72  E-value: 2.04e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201877459  18 VTKYKMGGDIANRVLRAVVEEANSGASVLCLCEKGDAMIMEETGkifkkekemkkGIAFPTSISVNN--CVCHFSPlksd 95
Cdd:cd01066     1 IARLRKAAEIAEAAMAAAAEAIRPGVTEAEVAAAIEQALRAAGG-----------YPAGPTIVGSGArtALPHYRP---- 65

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201877459  96 QDYILKDGDLVKIDLGVHVDGFIANVAHSFVIDaskenPVSGRKADVIKAAHLCAEAALRLVKPGNQNTQVTDAWNKIAH 175
Cdd:cd01066    66 DDRRLQEGDLVLVDLGGVYDGYHADLTRTFVIG-----EPSDEQRELYEAVREAQEAALAALRPGVTAEEVDAAAREVLE 140


                  ....*.
gi 1201877459 176 SFHCTP 181
Cdd:cd01066   141 EHGLGP 146
PRK05716 PRK05716
methionine aminopeptidase; Validated
 76-188 2.17e-14

methionine aminopeptidase; Validated


Pssm-ID: 235576 [Multi-domain]  Cd Length: 252  Bit Score: 72.47  E-value: 2.17e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201877459  76 FPTSI--SVNNCVCHFSPlksdQDYILKDGDLVKIDLGVHVDGFIANVAHSFVIdaskeNPVSGRKADVIKAAHLCAEAA 153
Cdd:PRK05716   64 FPKSIctSVNEVVCHGIP----SDKVLKEGDIVNIDVTVIKDGYHGDTSRTFGV-----GEISPEDKRLCEVTKEALYLG 134

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1201877459 154 LRLVKPGNQNTQVTDAWNKIAHSFHCTPIEGMLSH 188
Cdd:PRK05716  135 IAAVKPGARLGDIGHAIQKYAEAEGFSVVREYCGH 169
Map COG0024
Methionine aminopeptidase [Translation, ribosomal structure and biogenesis];
76-161 1.62e-13

Methionine aminopeptidase [Translation, ribosomal structure and biogenesis];


Pssm-ID: 439795 [Multi-domain]  Cd Length: 250  Bit Score: 69.65  E-value: 1.62e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201877459  76 FPTSI--SVNNCVCHFSPlksdQDYILKDGDLVKIDLGVHVDGFIANVAHSFVIdaskeNPVSGRKADVIKAAHLCAEAA 153
Cdd:COG0024    62 FPKSIctSVNEVVVHGIP----SDRVLKDGDIVNIDVGAILDGYHGDSARTFVV-----GEVSPEARRLVEVTEEALYAG 132


                  ....*...
gi 1201877459 154 LRLVKPGN 161
Cdd:COG0024   133 IAAAKPGN 140
met_pdase_I TIGR00500
methionine aminopeptidase, type I; Methionine aminopeptidase is a cobalt-binding enzyme. ...
 18-188 4.06e-12

methionine aminopeptidase, type I; Methionine aminopeptidase is a cobalt-binding enzyme. Bacterial and organellar examples (type I) differ from eukaroytic and archaeal (type II) examples in lacking a region of approximately 60 amino acids between the 4th and 5th cobalt-binding ligands. This model describes type I. The role of this protein in general is to produce the mature form of cytosolic proteins by removing the N-terminal methionine. [Protein fate, Protein modification and repair]


Pssm-ID: 129591 [Multi-domain]  Cd Length: 247  Bit Score: 65.45  E-value: 4.06e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201877459  18 VTKYKMGGDIANRVLRAVVEEANSGASVLCLCEKGDAMIMEETGK-IFKKEKEMKKGIAfptsISVNNCVCHFSPlksdQ 96
Cdd:TIGR00500   9 IEKIRKAGRLAAEVLEELEREVKPGVSTKELDRIAKDFIEKHGAKpAFLGYYGFPGSVC----ISVNEVVIHGIP----D 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201877459  97 DYILKDGDLVKIDLGVHVDGFIANVAHSFVIdaskeNPVSGRKADVIKAAHLCAEAALRLVKPGNQNTQVTDAWNKIAHS 176
Cdd:TIGR00500  81 KKVLKDGDIVNIDVGVIYDGYHGDTAKTFLV-----GKISPEAEKLLECTEESLYKAIEEAKPGNRIGEIGAAIQKYAEA 155

                         170
                  ....*....|..
gi 1201877459 177 FHCTPIEGMLSH 188
Cdd:TIGR00500 156 KGFSVVREYCGH 167
PRK12896 PRK12896
methionine aminopeptidase; Reviewed
 6-188 1.33e-11

methionine aminopeptidase; Reviewed


Pssm-ID: 237252 [Multi-domain]  Cd Length: 255  Bit Score: 64.09  E-value: 1.33e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201877459   6 EAAELTIAEDLVVTKYKMGGDIANRVLRAVVEEANSGASVLCLCEKGDAmIMEETGKI--FKKEKemkkgiAFPTS--IS 81
Cdd:PRK12896    4 EGRGMEIKSPRELEKMRKIGRIVATALKEMGKAVEPGMTTKELDRIAEK-RLEEHGAIpsPEGYY------GFPGStcIS 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201877459  82 VNNCVCHFSPlkSDQdyILKDGDLVKIDLGVHVDGFIANVAHSFVIDaskenPVSGRKADVIKAAHLCAEAALRLVKPGN 161
Cdd:PRK12896   77 VNEEVAHGIP--GPR--VIKDGDLVNIDVSAYLDGYHGDTGITFAVG-----PVSEEAEKLCRVAEEALWAGIKQVKAGR 147

                         170       180
                  ....*....|....*....|....*..
gi 1201877459 162 QNTQVTDAWNKIAHSFHCTPIEGMLSH 188
Cdd:PRK12896  148 PLNDIGRAIEDFAKKNGYSVVRDLTGH 174
PRK12318 PRK12318
methionyl aminopeptidase;
76-188 1.77e-07

methionyl aminopeptidase;


Pssm-ID: 183434 [Multi-domain]  Cd Length: 291  Bit Score: 52.13  E-value: 1.77e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201877459  76 FPTSI--SVNNCVCHFSPlksdQDYILKDGDLVKIDLGVHVDGFIANVAHSFVIdaskeNPVSGRKADVIKAAHLCAEAA 153
Cdd:PRK12318  104 FPKTIctSLNEVICHGIP----NDIPLKNGDIMNIDVSCIVDGYYGDCSRMVMI-----GEVSEIKKKVCQASLECLNAA 174

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1201877459 154 LRLVKPGNQNTQVTDAWNKIAHSFHCTPIEGMLSH 188
Cdd:PRK12318  175 IAILKPGIPLYEIGEVIENCADKYGFSVVDQFVGH 209
PepP COG0006
Xaa-Pro aminopeptidase [Amino acid transport and metabolism];
20-173 4.76e-05

Xaa-Pro aminopeptidase [Amino acid transport and metabolism];


Pssm-ID: 439777 [Multi-domain]  Cd Length: 299  Bit Score: 44.81  E-value: 4.76e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201877459  20 KYKMGGDIANRVLRAVVEEANSGASvlclcEKGDAMIMEETGKifkkeKEMKKGIAFPTSISV--NNCVCHFSPlksdQD 97
Cdd:COG0006    81 LMRKAARIADAAHEAALAALRPGVT-----EREVAAELEAAMR-----RRGAEGPSFDTIVASgeNAAIPHYTP----TD 146

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1201877459  98 YILKDGDLVKIDLGVHVDGFIANVAHSFVIDaskenPVSGRKADVIKAAHLCAEAALRLVKPGNQNTQVTDAWNKI 173
Cdd:COG0006   147 RPLKPGDLVLIDAGAEYDGYTSDITRTVAVG-----EPSDEQREIYEAVLEAQEAAIAALKPGVTGGEVDAAARDV 217
Prolidase cd01087
Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline ...
 77-190 6.51e-05

Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on Pro-Pro.


Pssm-ID: 238520 [Multi-domain]  Cd Length: 243  Bit Score: 44.10  E-value: 6.51e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201877459  77 PTSIS-VNNCVCHFSPLksdqDYILKDGDLVKIDLGVHVDGFIANVAHSFvidaskenPVSGRK----ADVIKAAHLCAE 151
Cdd:cd01087    50 YIVAAgSNAAILHYVHN----DQPLKDGDLVLIDAGAEYGGYASDITRTF--------PVNGKFtdeqRELYEAVLAAQK 117

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1201877459 152 AALRLVKPGNQNTQVTDAWNKIAHsfhctpiEGMLSHQL 190
Cdd:cd01087   118 AAIAACKPGVSYEDIHLLAHRVLA-------EGLKELGI 149
PRK15173 PRK15173
peptidase; Provisional
 89-169 2.95e-04

peptidase; Provisional


Pssm-ID: 185095 [Multi-domain]  Cd Length: 323  Bit Score: 42.40  E-value: 2.95e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201877459  89 FSPLKSDQDYILKDGDLVKIDLGVHVDGFIANVAHSFVIDASKEnpVSGRKADVIKAAHlcaEAALRLVKPGNQNTQVTD 168
Cdd:PRK15173  159 FSPKLIPSNTKACSGDLIKFDCGVDVDGYGADIARTFVVGEPPE--ITRKIYQTIRTGH---EHMLSMVAPGVKMKDVFD 233


                  .
gi 1201877459 169 A 169
Cdd:PRK15173  234 S 234
PRK14575 PRK14575
putative peptidase; Provisional
 89-169 4.08e-04

putative peptidase; Provisional


Pssm-ID: 173039 [Multi-domain]  Cd Length: 406  Bit Score: 42.39  E-value: 4.08e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201877459  89 FSPLKSDQDYILKDGDLVKIDLGVHVDGFIANVAHSFVIDASKEnpVSGRKADVIKAAHlcaEAALRLVKPGNQNTQVTD 168
Cdd:PRK14575  242 FSPKLIPSNTKACSGDLIKFDCGVDVDGYGADIARTFVVGEPPE--ITRKIYQTIRTGH---EHMLSMVAPGVKMKDVFD 316


                  .
gi 1201877459 169 A 169
Cdd:PRK14575  317 S 317
PRK10879 PRK10879
proline aminopeptidase P II; Provisional
 83-169 3.27e-03

proline aminopeptidase P II; Provisional


Pssm-ID: 182804 [Multi-domain]  Cd Length: 438  Bit Score: 39.32  E-value: 3.27e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201877459  83 NNCVCHFSPLKSDqdyiLKDGDLVKIDLGVHVDGFIANVAHSFvidaskenPVSGRKA-------DVIKAAhlcAEAALR 155
Cdd:PRK10879  236 NGCILHYTENESE----MRDGDLVLIDAGCEYKGYAGDITRTF--------PVNGKFTpaqreiyDIVLES---LETSLR 300

                          90
                  ....*....|....
gi 1201877459 156 LVKPGNQNTQVTDA 169
Cdd:PRK10879  301 LYRPGTSIREVTGE 314
APP-like cd01092
Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse ...
 67-160 8.83e-03

Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline.


Pssm-ID: 238525 [Multi-domain]  Cd Length: 208  Bit Score: 37.10  E-value: 8.83e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201877459  67 EKEMKK----GIAFPTSIS--VNNCVCHFSPlkSDQdyILKDGDLVKIDLGVHVDGFIANVAHSFVI-DASKENpvsgRK 139
Cdd:cd01092    36 EYFMRKlgaeGPSFDTIVAsgPNSALPHGVP--SDR--KIEEGDLVLIDFGAIYDGYCSDITRTVAVgEPSDEL----KE 107

                          90       100
                  ....*....|....*....|..
gi 1201877459 140 A-DVIKAAHlcaEAALRLVKPG 160
Cdd:cd01092   108 IyEIVLEAQ---QAAIKAVKPG 126
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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