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Conserved domains on  [gi|1207171015|ref|XP_021330572|]
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uncharacterized protein LOC100141328 isoform X1 [Danio rerio]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
102-261 1.46e-05

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.00  E-value: 1.46e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207171015 102 SYTCQQCGKIFHYARNLAAHMR--IHTGE--KPYSCP--QCGKSFKQNNNLEVHMRTHTGERSFTCTQCGKSFAKKQNLK 175
Cdd:COG5048   289 PIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPysLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLN 368

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207171015 176 I-------HMRIHTGEKPFTCTECGKSFRCKSTFNI--HKRTHTGEKP--YRCTECGKSFPNKSTFNNHMRIHTGEKPYR 244
Cdd:COG5048   369 NeppqslqQYKDLKNDKKSETLSNSCIRNFKRDSNLslHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLL 448

                         170
                  ....*....|....*..
gi 1207171015 245 CTECGKSFIRKSTLNYH 261
Cdd:COG5048   449 CSILKSFRRDLDLSNHG 465
DUF6431 super family cl45402
Domain of unknown function (DUF6431); This domain of unknown function is found in ...
 301-333 9.30e-04

Domain of unknown function (DUF6431); This domain of unknown function is found in uncharacterized proteins from bacteria. This domain is about 90 amino acids in length. It contains the conserved sequences CxxC, RxxCxxxxC and a conserved LP motif.


The actual alignment was detected with superfamily member pfam20020:

Pssm-ID: 437852 [Multi-domain]  Cd Length: 82  Bit Score: 37.59  E-value: 9.30e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1207171015 301 CDQCGKSLTRKDSIKRHMKTHSGE-------RFRCSECGK 333
Cdd:pfam20020   1 CPCCGGKLKVIDSRRRIVIKSGGEkewinirRLRCSKCGK 40
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
102-261 1.46e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.00  E-value: 1.46e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207171015 102 SYTCQQCGKIFHYARNLAAHMR--IHTGE--KPYSCP--QCGKSFKQNNNLEVHMRTHTGERSFTCTQCGKSFAKKQNLK 175
Cdd:COG5048   289 PIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPysLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLN 368

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207171015 176 I-------HMRIHTGEKPFTCTECGKSFRCKSTFNI--HKRTHTGEKP--YRCTECGKSFPNKSTFNNHMRIHTGEKPYR 244
Cdd:COG5048   369 NeppqslqQYKDLKNDKKSETLSNSCIRNFKRDSNLslHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLL 448

                         170
                  ....*....|....*..
gi 1207171015 245 CTECGKSFIRKSTLNYH 261
Cdd:COG5048   449 CSILKSFRRDLDLSNHG 465
zf-H2C2_2 pfam13465
Zinc-finger double domain;
117-142 1.32e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 1.32e-04
                          10        20
                  ....*....|....*....|....*.
gi 1207171015 117 NLAAHMRIHTGEKPYSCPQCGKSFKQ 142
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
DUF6431 pfam20020
Domain of unknown function (DUF6431); This domain of unknown function is found in ...
 301-333 9.30e-04

Domain of unknown function (DUF6431); This domain of unknown function is found in uncharacterized proteins from bacteria. This domain is about 90 amino acids in length. It contains the conserved sequences CxxC, RxxCxxxxC and a conserved LP motif.


Pssm-ID: 437852 [Multi-domain]  Cd Length: 82  Bit Score: 37.59  E-value: 9.30e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1207171015 301 CDQCGKSLTRKDSIKRHMKTHSGE-------RFRCSECGK 333
Cdd:pfam20020   1 CPCCGGKLKVIDSRRRIVIKSGGEkewinirRLRCSKCGK 40
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
102-261 1.46e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.00  E-value: 1.46e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207171015 102 SYTCQQCGKIFHYARNLAAHMR--IHTGE--KPYSCP--QCGKSFKQNNNLEVHMRTHTGERSFTCTQCGKSFAKKQNLK 175
Cdd:COG5048   289 PIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPysLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLN 368

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207171015 176 I-------HMRIHTGEKPFTCTECGKSFRCKSTFNI--HKRTHTGEKP--YRCTECGKSFPNKSTFNNHMRIHTGEKPYR 244
Cdd:COG5048   369 NeppqslqQYKDLKNDKKSETLSNSCIRNFKRDSNLslHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLL 448

                         170
                  ....*....|....*..
gi 1207171015 245 CTECGKSFIRKSTLNYH 261
Cdd:COG5048   449 CSILKSFRRDLDLSNHG 465
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
110-359 1.85e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 46.61  E-value: 1.85e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207171015 110 KIFHYARNLAAHMRIHTGEKPYSCPQCGKSFKQNNNLEVHMRTHTGERSFTCTQCGKSFAKKQNLKIHMRIHTGEKPFTC 189
Cdd:COG5048   178 KDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSA 257

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207171015 190 TECGKSFRCKSTFNIHKRTHTGE-------KPYRCTECGKSFPNKSTFNNHMR--IHTGE--KPYRCTE--CGKSFIRKS 256
Cdd:COG5048   258 SESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRND 337

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207171015 257 TLNYHVRTHTGEKLFACV--QCGKSFTTKL-----SLMNHMNGHTGTIVFTCD--QCGKSLTRKDSIKRHMKTHSGER-- 325
Cdd:COG5048   338 ALKRHILLHTSISPAKEKllNSSSKFSPLLnneppQSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRpy 417

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1207171015 326 -FRCSECGKDFKHERSLRAHMKLHNAEQSPQHLGL 359
Cdd:COG5048   418 nCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSIL 452
zf-H2C2_2 pfam13465
Zinc-finger double domain;
117-142 1.32e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 1.32e-04
                          10        20
                  ....*....|....*....|....*.
gi 1207171015 117 NLAAHMRIHTGEKPYSCPQCGKSFKQ 142
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
19-335 1.65e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.53  E-value: 1.65e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207171015  19 DIPTDEKPTLTKKTSSHRRHLNYKSECNFSCKQSRKSFSQKPNLDVYTRVHNReKHYTCKQCGKSFPKIHFLkaHMRIHI 98
Cdd:COG5048   118 NDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPP-LPANSLSKDPSSNLSLLI--SSNVST 194

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207171015  99 GERSYTCQQCGKIFHYARNLAAHMRIHTGEKPYSCPQCGKSFKQNNNLEVHMRTHTGERSFTCTQCGKSFAKKQNLKIHM 178
Cdd:COG5048   195 SIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSS 274

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207171015 179 RIHTGE-------KPFTCTECGKSFRCKSTFNIHKRT--HTGE--KPYRCTE--CGKSFPNKSTFNNHMRIHTGEKPYRC 245
Cdd:COG5048   275 PNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKE 354

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207171015 246 --TECGKSFIRKSTLNYHVRTH-----TGEKLFACV--QCGKSFTTKLSLMNHMNGHT--GTIVFTCDQCGKSLTRKDSI 314
Cdd:COG5048   355 klLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETLsnSCIRNFKRDSNLSLHIITHLsfRPYNCKNPPCSKSFNRHYNL 434

                         330       340
                  ....*....|....*....|.
gi 1207171015 315 KRHMKTHSGERFRCSECGKDF 335
Cdd:COG5048   435 IPHKKIHTNHAPLLCSILKSF 455
zf-H2C2_2 pfam13465
Zinc-finger double domain;
173-198 2.03e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 2.03e-04
                          10        20
                  ....*....|....*....|....*.
gi 1207171015 173 NLKIHMRIHTGEKPFTCTECGKSFRC 198
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
47-206 3.89e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 42.38  E-value: 3.89e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207171015  47 FSCKQSRKSFSQKPNL--DVYTRVHNREKHYTCKQ----CGKSFPKIHFLKAHMRIHIGERSYTCQQCGKIFHYARNLAA 120
Cdd:COG5048   290 IKSKQCNISFSRSSPLtrHLRSVNHSGESLKPFSCpyslCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLNN 369

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207171015 121 -------HMRIHTGEKPYSC--PQCGKSFKQNNNLEVHMRTHTGERS--FTCTQCGKSFAKKQNLKIHMRIHTGEKPFTC 189
Cdd:COG5048   370 eppqslqQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLC 449

                         170
                  ....*....|....*..
gi 1207171015 190 TECGKSFRCKSTFNIHK 206
Cdd:COG5048   450 SILKSFRRDLDLSNHGK 466
DUF6431 pfam20020
Domain of unknown function (DUF6431); This domain of unknown function is found in ...
 301-333 9.30e-04

Domain of unknown function (DUF6431); This domain of unknown function is found in uncharacterized proteins from bacteria. This domain is about 90 amino acids in length. It contains the conserved sequences CxxC, RxxCxxxxC and a conserved LP motif.


Pssm-ID: 437852 [Multi-domain]  Cd Length: 82  Bit Score: 37.59  E-value: 9.30e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1207171015 301 CDQCGKSLTRKDSIKRHMKTHSGE-------RFRCSECGK 333
Cdd:pfam20020   1 CPCCGGKLKVIDSRRRIVIKSGGEkewinirRLRCSKCGK 40
zf-H2C2_2 pfam13465
Zinc-finger double domain;
230-254 1.17e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.17e-03
                          10        20
                  ....*....|....*....|....*
gi 1207171015 230 FNNHMRIHTGEKPYRCTECGKSFIR 254
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 72-154 1.39e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.47  E-value: 1.39e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207171015  72 EKHYTCK--QCGKSFPKIHFLKAHMrIHigersytcQQCGKIFHYARNLAAHMRIHTGEKPYSCPQCGKSFKQNNNLEVH 149
Cdd:COG5189   347 GKPYKCPveGCNKKYKNQNGLKYHM-LH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKYH 417


                  ....*
gi 1207171015 150 mRTHT 154
Cdd:COG5189   418 -RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
145-170 1.63e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 1.63e-03
                          10        20
                  ....*....|....*....|....*.
gi 1207171015 145 NLEVHMRTHTGERSFTCTQCGKSFAK 170
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
205-224 5.73e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 5.73e-03
                          10        20
                  ....*....|....*....|
gi 1207171015 205 HKRTHTGEKPYRCTECGKSF 224
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSF 24
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 131-153 6.55e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 33.81  E-value: 6.55e-03
                          10        20
                  ....*....|....*....|...
gi 1207171015 131 YSCPQCGKSFKQNNNLEVHMRTH 153
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
213-322 8.93e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 38.14  E-value: 8.93e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207171015 213 KPYRCTECGKSFPNKSTFNNHMRIHTGEKPYRCT--ECGKSFIRKSTLNYHVRTHTGEKLFAC-VQCGKSFTTKLSLMNH 289
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLS 111

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1207171015 290 MNGHTGTIVFTCDQCGKSLTRKDSIKRHMKTHS 322
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSIS 144
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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