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Conserved domains on  [gi|1207117088|ref|XP_021336974|]
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protocadherin gamma-A11-like [Danio rerio]

Protein Classification

protocadherin( domain architecture ID 13228193)

protocadherin may have tightly regulated functions in the development, regionalization, and functional differentiation of the central nervous system

CATH:  2.60.40.60
Gene Ontology:  GO:0007156|GO:0005509
PubMed:  28268172|18430161
SCOP:  4007535

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cadherin_2 super family cl29227
Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.
 10-92 2.55e-29

Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.


The actual alignment was detected with superfamily member pfam08266:

Pssm-ID: 462413  Cd Length: 83  Bit Score: 111.47  E-value: 2.55e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207117088  10 QIRYSVSEEQKDGAVVGNLAKDLGLDPRTLKERGFRIVSTSGDSLFTVNQNDGILSVNGKIDREVVCERISSCNINLKIA 89
Cdd:pfam08266   1 QIRYSVPEETERGSFVGNLAKDLGLEVGELAARGARVVSKGNKQYFQLNPETGDLLLNEKLDREELCGSTEPCVLHFQVL 80


                  ...
gi 1207117088  90 LEN 92
Cdd:pfam08266  81 LEN 83
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 226-326 6.07e-29

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 110.87  E-value: 6.07e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207117088 226 VYSVTLKENVPVGTTVIQVNATDMDDGPNGEVFYSFGKDIDSrltKLFDLNSITGEMTVIGQIDFEEMNSFEIDIQASDK 305
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNED---GLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDG 77

                          90       100
                  ....*....|....*....|.
gi 1207117088 306 GSVPLTSDKSITIKIIDVNDN 326
Cdd:cd11304    78 GGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 440-542 1.61e-25

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 101.24  E-value: 1.61e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207117088 440 PYAFYVFENNIAGKLLFSVSASDRDLDDNAVVKYSIwrDSGDENKYTSfinINSENGEIYGLKGFDFETIKMFQFHVIAT 519
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSI--VSGNEDGLFS---IDPSTGEITTAKPLDREEQSSYTLTVTAT 75

                          90       100
                  ....*....|....*....|...
gi 1207117088 520 DSGSPSLSSNVTVNVFILDQNDN 542
Cdd:cd11304    76 DGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 339-432 5.92e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 93.92  E-value: 5.92e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207117088 339 VPEDCKTGTTVALISVSDSDSGVNGKVLCYITEDTPFRLMASSQDNiYALVTASSLDRESVPRYDITLLAKDAGQPPLSS 418
Cdd:cd11304     6 VPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPST-GEITTAKPLDREEQSSYTLTVTATDGGGPPLSS 84

                          90
                  ....*....|....
gi 1207117088 419 VKTITVQVSDVNDN 432
Cdd:cd11304    85 TATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 561-649 1.59e-20

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 86.98  E-value: 1.59e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207117088 561 EIPRNVNAGHLVTKVRAYDADIGYNGWLLFSLQEVSEHSLFALDRYTGQIRTLRSFTETDEAQHKLVILVKDNGNVSLSA 640
Cdd:cd11304     5 SVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPLSS 84


                  ....*....
gi 1207117088 641 TATVIVKVV 649
Cdd:cd11304    85 TATVTITVL 93
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 120-218 2.79e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 83.52  E-value: 2.79e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207117088 120 LEIWESALPGAR-YQLQAaRDPDGGVNSVQQYKLSHND---HFRIEvKDRGEdrkmpfLILQKPLDRETSRKHKLVLTAL 195
Cdd:cd11304     4 VSVPENAPPGTVvLTVSA-TDPDSGENGEVTYSIVSGNedgLFSID-PSTGE------ITTAKPLDREEQSSYTLTVTAT 75

                          90       100
                  ....*....|....*....|...
gi 1207117088 196 DGGRPPKSGTMEIIVDVLDVNDN 218
Cdd:cd11304    76 DGGGPPLSSTATVTITVLDVNDN 98
Cadherin_C_2 pfam16492
Cadherin cytoplasmic C-terminal; Cadherin_C_2 is the cytoplasmic C-terminal domain of some ...
 671-725 2.60e-08

Cadherin cytoplasmic C-terminal; Cadherin_C_2 is the cytoplasmic C-terminal domain of some proto-cadherins. It is this region of the cadherins that allows cell-adhesion and the essential feature of metazoan multicellularity. Cadherins are cell-surface receptors that function in cell adhesion, cell polarity, and tissue morphogenesis.


:

Pssm-ID: 465139  Cd Length: 84  Bit Score: 51.76  E-value: 2.60e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1207117088 671 NVTFYLIITLGSVSVLFVISIIVLIVMQCSKS----TDYSSKYLQ-------DTNY-DGTLCHSIQY 725
Cdd:pfam16492   1 DLTFYLVIALASVSFLFLLFVIVLIALRLRRWrssaLLQSSGNLCsvpaphfPGNDgTGTLPQSYSY 67
 
Name Accession Description Interval E-value
Cadherin_2 pfam08266
Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.
 10-92 2.55e-29

Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.


Pssm-ID: 462413  Cd Length: 83  Bit Score: 111.47  E-value: 2.55e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207117088  10 QIRYSVSEEQKDGAVVGNLAKDLGLDPRTLKERGFRIVSTSGDSLFTVNQNDGILSVNGKIDREVVCERISSCNINLKIA 89
Cdd:pfam08266   1 QIRYSVPEETERGSFVGNLAKDLGLEVGELAARGARVVSKGNKQYFQLNPETGDLLLNEKLDREELCGSTEPCVLHFQVL 80


                  ...
gi 1207117088  90 LEN 92
Cdd:pfam08266  81 LEN 83
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 226-326 6.07e-29

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 110.87  E-value: 6.07e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207117088 226 VYSVTLKENVPVGTTVIQVNATDMDDGPNGEVFYSFGKDIDSrltKLFDLNSITGEMTVIGQIDFEEMNSFEIDIQASDK 305
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNED---GLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDG 77

                          90       100
                  ....*....|....*....|.
gi 1207117088 306 GSVPLTSDKSITIKIIDVNDN 326
Cdd:cd11304    78 GGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 440-542 1.61e-25

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 101.24  E-value: 1.61e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207117088 440 PYAFYVFENNIAGKLLFSVSASDRDLDDNAVVKYSIwrDSGDENKYTSfinINSENGEIYGLKGFDFETIKMFQFHVIAT 519
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSI--VSGNEDGLFS---IDPSTGEITTAKPLDREEQSSYTLTVTAT 75

                          90       100
                  ....*....|....*....|...
gi 1207117088 520 DSGSPSLSSNVTVNVFILDQNDN 542
Cdd:cd11304    76 DGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 339-432 5.92e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 93.92  E-value: 5.92e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207117088 339 VPEDCKTGTTVALISVSDSDSGVNGKVLCYITEDTPFRLMASSQDNiYALVTASSLDRESVPRYDITLLAKDAGQPPLSS 418
Cdd:cd11304     6 VPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPST-GEITTAKPLDREEQSSYTLTVTATDGGGPPLSS 84

                          90
                  ....*....|....
gi 1207117088 419 VKTITVQVSDVNDN 432
Cdd:cd11304    85 TATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 561-649 1.59e-20

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 86.98  E-value: 1.59e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207117088 561 EIPRNVNAGHLVTKVRAYDADIGYNGWLLFSLQEVSEHSLFALDRYTGQIRTLRSFTETDEAQHKLVILVKDNGNVSLSA 640
Cdd:cd11304     5 SVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPLSS 84


                  ....*....
gi 1207117088 641 TATVIVKVV 649
Cdd:cd11304    85 TATVTITVL 93
Cadherin pfam00028
Cadherin domain;
227-321 3.36e-20

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 85.82  E-value: 3.36e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207117088 227 YSVTLKENVPVGTTVIQVNATDMDDGPNGEVFYSFGKDIDSRltkLFDLNSITGEMTVIGQIDFEEMNSFEIDIQASDKG 306
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGG---NFRIDPDTGDISTTKPLDRESIGEYELTVEATDSG 77

                          90
                  ....*....|....*
gi 1207117088 307 SVPLTSDKSITIKII 321
Cdd:pfam00028  78 GPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 459-544 1.02e-19

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 83.94  E-value: 1.02e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207117088  459 SASDRDLDDNAVVKYSIWRDSGDenkytSFININSENGEIYGLKGFDFETIKMFQFHVIATDSGSPSLSSNVTVNVFILD 538
Cdd:smart00112   1 SATDADSGENGKVTYSILSGNDD-----GLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLD 75


                   ....*.
gi 1207117088  539 QNDNVP 544
Cdd:smart00112  76 VNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 245-328 1.78e-19

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 83.17  E-value: 1.78e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207117088  245 NATDMDDGPNGEVFYSFGKDIDSRLtklFDLNSITGEMTVIGQIDFEEMNSFEIDIQASDKGSVPLTSDKSITIKIIDVN 324
Cdd:smart00112   1 SATDADSGENGKVTYSILSGNDDGL---FSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVN 77


                   ....
gi 1207117088  325 DNVP 328
Cdd:smart00112  78 DNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 120-218 2.79e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 83.52  E-value: 2.79e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207117088 120 LEIWESALPGAR-YQLQAaRDPDGGVNSVQQYKLSHND---HFRIEvKDRGEdrkmpfLILQKPLDRETSRKHKLVLTAL 195
Cdd:cd11304     4 VSVPENAPPGTVvLTVSA-TDPDSGENGEVTYSIVSGNedgLFSID-PSTGE------ITTAKPLDREEQSSYTLTVTAT 75

                          90       100
                  ....*....|....*....|...
gi 1207117088 196 DGGRPPKSGTMEIIVDVLDVNDN 218
Cdd:cd11304    76 DGGGPPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 353-434 8.16e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 75.85  E-value: 8.16e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207117088  353 SVSDSDSGVNGKVLCYIT---EDTPFRLMASSQDniyaLVTASSLDRESVPRYDITLLAKDAGQPPLSSVKTITVQVSDV 429
Cdd:smart00112   1 SATDADSGENGKVTYSILsgnDDGLFSIDPETGE----ITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDV 76


                   ....*
gi 1207117088  430 NDNSP 434
Cdd:smart00112  77 NDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 137-220 4.62e-16

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 73.54  E-value: 4.62e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207117088  137 ARDPDGGVNSVQQYKLS---HNDHFRIEvKDRGEdrkmpfLILQKPLDRETSRKHKLVLTALDGGRPPKSGTMEIIVDVL 213
Cdd:smart00112   2 ATDADSGENGKVTYSILsgnDDGLFSID-PETGE------ITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVL 74


                   ....*..
gi 1207117088  214 DVNDNMP 220
Cdd:smart00112  75 DVNDNAP 81
Cadherin pfam00028
Cadherin domain;
335-426 5.67e-16

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 73.87  E-value: 5.67e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207117088 335 FSSAVPEDCKTGTTVALISVSDSDSGVNGKVLCYITEDTP---FRLMASSQDniyaLVTASSLDRESVPRYDITLLAKDA 411
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPggnFRIDPDTGD----ISTTKPLDRESIGEYELTVEATDS 76

                          90
                  ....*....|....*
gi 1207117088 412 GQPPLSSVKTITVQV 426
Cdd:pfam00028  77 GGPPLSSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
441-537 1.87e-14

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 69.25  E-value: 1.87e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207117088 441 YAFYVFENNIAGKLLFSVSASDRDLDDNAVVKYSIwrDSGDENKytSFInINSENGEIYGLKGFDFETIKMFQFHVIATD 520
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSI--LGGGPGG--NFR-IDPDTGDISTTKPLDRESIGEYELTVEATD 75

                          90
                  ....*....|....*..
gi 1207117088 521 SGSPSLSSNVTVNVFIL 537
Cdd:pfam00028  76 SGGPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 576-649 5.75e-13

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 64.68  E-value: 5.75e-13
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1207117088  576 RAYDADIGYNGWLLFSLQEVSEHSLFALDRYTGQIRTLRSFTETDEAQHKLVILVKDNGNVSLSATATVIVKVV 649
Cdd:smart00112   1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVL 74
Cadherin pfam00028
Cadherin domain;
561-648 2.11e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 63.47  E-value: 2.11e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207117088 561 EIPRNVNAGHLVTKVRAYDADIGYNGWLLFSLQEVSEHSLFALDRYTGQIRTLRSFTETDEAQHKLVILVKDNGNVSLSA 640
Cdd:pfam00028   4 SVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPLSS 83


                  ....*...
gi 1207117088 641 TATVIVKV 648
Cdd:pfam00028  84 TATVTITV 91
Cadherin pfam00028
Cadherin domain;
121-213 1.38e-11

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 61.16  E-value: 1.38e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207117088 121 EIWESALPGARYQLQAARDPDGGVNSVQQYKLS---HNDHFRIEvKDRGEdrkmpfLILQKPLDRETSRKHKLVLTALDG 197
Cdd:pfam00028   4 SVPENAPVGTEVLTVTATDPDLGPNGRIFYSILgggPGGNFRID-PDTGD------ISTTKPLDRESIGEYELTVEATDS 76

                          90
                  ....*....|....*.
gi 1207117088 198 GRPPKSGTMEIIVDVL 213
Cdd:pfam00028  77 GGPPLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 10-109 1.52e-09

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 55.78  E-value: 1.52e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207117088  10 QIRYSVSEEQKDGAVVGNL-AKDLglDPRTLKERGFRIVSTSGDSLFTVNQNDGILSVNGKIDREvvceriSSCNINLKI 88
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVsATDP--DSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDRE------EQSSYTLTV 72

                          90       100
                  ....*....|....*....|....*.
gi 1207117088  89 -ALENPLEIHY----VSIEIVDVNDH 109
Cdd:cd11304    73 tATDGGGPPLSstatVTITVLDVNDN 98
Cadherin_C_2 pfam16492
Cadherin cytoplasmic C-terminal; Cadherin_C_2 is the cytoplasmic C-terminal domain of some ...
 671-725 2.60e-08

Cadherin cytoplasmic C-terminal; Cadherin_C_2 is the cytoplasmic C-terminal domain of some proto-cadherins. It is this region of the cadherins that allows cell-adhesion and the essential feature of metazoan multicellularity. Cadherins are cell-surface receptors that function in cell adhesion, cell polarity, and tissue morphogenesis.


Pssm-ID: 465139  Cd Length: 84  Bit Score: 51.76  E-value: 2.60e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1207117088 671 NVTFYLIITLGSVSVLFVISIIVLIVMQCSKS----TDYSSKYLQ-------DTNY-DGTLCHSIQY 725
Cdd:pfam16492   1 DLTFYLVIALASVSFLFLLFVIVLIALRLRRWrssaLLQSSGNLCsvpaphfPGNDgTGTLPQSYSY 67
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 44-111 6.13e-07

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 47.73  E-value: 6.13e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1207117088   44 FRIVSTSGDSLFTVNQNDGILSVNGKIDREVvcerISSCNINLKI--ALENPLE-IHYVSIEIVDVNDHAP 111
Cdd:smart00112  15 YSILSGNDDGLFSIDPETGEITTTKPLDREE----QPEYTLTVEAtdGGGPPLSsTATVTITVLDVNDNAP 81
 
Name Accession Description Interval E-value
Cadherin_2 pfam08266
Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.
 10-92 2.55e-29

Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.


Pssm-ID: 462413  Cd Length: 83  Bit Score: 111.47  E-value: 2.55e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207117088  10 QIRYSVSEEQKDGAVVGNLAKDLGLDPRTLKERGFRIVSTSGDSLFTVNQNDGILSVNGKIDREVVCERISSCNINLKIA 89
Cdd:pfam08266   1 QIRYSVPEETERGSFVGNLAKDLGLEVGELAARGARVVSKGNKQYFQLNPETGDLLLNEKLDREELCGSTEPCVLHFQVL 80


                  ...
gi 1207117088  90 LEN 92
Cdd:pfam08266  81 LEN 83
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 226-326 6.07e-29

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 110.87  E-value: 6.07e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207117088 226 VYSVTLKENVPVGTTVIQVNATDMDDGPNGEVFYSFGKDIDSrltKLFDLNSITGEMTVIGQIDFEEMNSFEIDIQASDK 305
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNED---GLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDG 77

                          90       100
                  ....*....|....*....|.
gi 1207117088 306 GSVPLTSDKSITIKIIDVNDN 326
Cdd:cd11304    78 GGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 440-542 1.61e-25

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 101.24  E-value: 1.61e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207117088 440 PYAFYVFENNIAGKLLFSVSASDRDLDDNAVVKYSIwrDSGDENKYTSfinINSENGEIYGLKGFDFETIKMFQFHVIAT 519
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSI--VSGNEDGLFS---IDPSTGEITTAKPLDREEQSSYTLTVTAT 75

                          90       100
                  ....*....|....*....|...
gi 1207117088 520 DSGSPSLSSNVTVNVFILDQNDN 542
Cdd:cd11304    76 DGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 339-432 5.92e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 93.92  E-value: 5.92e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207117088 339 VPEDCKTGTTVALISVSDSDSGVNGKVLCYITEDTPFRLMASSQDNiYALVTASSLDRESVPRYDITLLAKDAGQPPLSS 418
Cdd:cd11304     6 VPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPST-GEITTAKPLDREEQSSYTLTVTATDGGGPPLSS 84

                          90
                  ....*....|....
gi 1207117088 419 VKTITVQVSDVNDN 432
Cdd:cd11304    85 TATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 561-649 1.59e-20

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 86.98  E-value: 1.59e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207117088 561 EIPRNVNAGHLVTKVRAYDADIGYNGWLLFSLQEVSEHSLFALDRYTGQIRTLRSFTETDEAQHKLVILVKDNGNVSLSA 640
Cdd:cd11304     5 SVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPLSS 84


                  ....*....
gi 1207117088 641 TATVIVKVV 649
Cdd:cd11304    85 TATVTITVL 93
Cadherin pfam00028
Cadherin domain;
227-321 3.36e-20

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 85.82  E-value: 3.36e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207117088 227 YSVTLKENVPVGTTVIQVNATDMDDGPNGEVFYSFGKDIDSRltkLFDLNSITGEMTVIGQIDFEEMNSFEIDIQASDKG 306
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGG---NFRIDPDTGDISTTKPLDRESIGEYELTVEATDSG 77

                          90
                  ....*....|....*
gi 1207117088 307 SVPLTSDKSITIKII 321
Cdd:pfam00028  78 GPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 459-544 1.02e-19

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 83.94  E-value: 1.02e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207117088  459 SASDRDLDDNAVVKYSIWRDSGDenkytSFININSENGEIYGLKGFDFETIKMFQFHVIATDSGSPSLSSNVTVNVFILD 538
Cdd:smart00112   1 SATDADSGENGKVTYSILSGNDD-----GLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLD 75


                   ....*.
gi 1207117088  539 QNDNVP 544
Cdd:smart00112  76 VNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 245-328 1.78e-19

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 83.17  E-value: 1.78e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207117088  245 NATDMDDGPNGEVFYSFGKDIDSRLtklFDLNSITGEMTVIGQIDFEEMNSFEIDIQASDKGSVPLTSDKSITIKIIDVN 324
Cdd:smart00112   1 SATDADSGENGKVTYSILSGNDDGL---FSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVN 77


                   ....
gi 1207117088  325 DNVP 328
Cdd:smart00112  78 DNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 120-218 2.79e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 83.52  E-value: 2.79e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207117088 120 LEIWESALPGAR-YQLQAaRDPDGGVNSVQQYKLSHND---HFRIEvKDRGEdrkmpfLILQKPLDRETSRKHKLVLTAL 195
Cdd:cd11304     4 VSVPENAPPGTVvLTVSA-TDPDSGENGEVTYSIVSGNedgLFSID-PSTGE------ITTAKPLDREEQSSYTLTVTAT 75

                          90       100
                  ....*....|....*....|...
gi 1207117088 196 DGGRPPKSGTMEIIVDVLDVNDN 218
Cdd:cd11304    76 DGGGPPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 353-434 8.16e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 75.85  E-value: 8.16e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207117088  353 SVSDSDSGVNGKVLCYIT---EDTPFRLMASSQDniyaLVTASSLDRESVPRYDITLLAKDAGQPPLSSVKTITVQVSDV 429
Cdd:smart00112   1 SATDADSGENGKVTYSILsgnDDGLFSIDPETGE----ITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDV 76


                   ....*
gi 1207117088  430 NDNSP 434
Cdd:smart00112  77 NDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 137-220 4.62e-16

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 73.54  E-value: 4.62e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207117088  137 ARDPDGGVNSVQQYKLS---HNDHFRIEvKDRGEdrkmpfLILQKPLDRETSRKHKLVLTALDGGRPPKSGTMEIIVDVL 213
Cdd:smart00112   2 ATDADSGENGKVTYSILsgnDDGLFSID-PETGE------ITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVL 74


                   ....*..
gi 1207117088  214 DVNDNMP 220
Cdd:smart00112  75 DVNDNAP 81
Cadherin pfam00028
Cadherin domain;
335-426 5.67e-16

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 73.87  E-value: 5.67e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207117088 335 FSSAVPEDCKTGTTVALISVSDSDSGVNGKVLCYITEDTP---FRLMASSQDniyaLVTASSLDRESVPRYDITLLAKDA 411
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPggnFRIDPDTGD----ISTTKPLDRESIGEYELTVEATDS 76

                          90
                  ....*....|....*
gi 1207117088 412 GQPPLSSVKTITVQV 426
Cdd:pfam00028  77 GGPPLSSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
441-537 1.87e-14

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 69.25  E-value: 1.87e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207117088 441 YAFYVFENNIAGKLLFSVSASDRDLDDNAVVKYSIwrDSGDENKytSFInINSENGEIYGLKGFDFETIKMFQFHVIATD 520
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSI--LGGGPGG--NFR-IDPDTGDISTTKPLDRESIGEYELTVEATD 75

                          90
                  ....*....|....*..
gi 1207117088 521 SGSPSLSSNVTVNVFIL 537
Cdd:pfam00028  76 SGGPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 576-649 5.75e-13

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 64.68  E-value: 5.75e-13
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1207117088  576 RAYDADIGYNGWLLFSLQEVSEHSLFALDRYTGQIRTLRSFTETDEAQHKLVILVKDNGNVSLSATATVIVKVV 649
Cdd:smart00112   1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVL 74
Cadherin pfam00028
Cadherin domain;
561-648 2.11e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 63.47  E-value: 2.11e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207117088 561 EIPRNVNAGHLVTKVRAYDADIGYNGWLLFSLQEVSEHSLFALDRYTGQIRTLRSFTETDEAQHKLVILVKDNGNVSLSA 640
Cdd:pfam00028   4 SVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPLSS 83


                  ....*...
gi 1207117088 641 TATVIVKV 648
Cdd:pfam00028  84 TATVTITV 91
Cadherin pfam00028
Cadherin domain;
121-213 1.38e-11

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 61.16  E-value: 1.38e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207117088 121 EIWESALPGARYQLQAARDPDGGVNSVQQYKLS---HNDHFRIEvKDRGEdrkmpfLILQKPLDRETSRKHKLVLTALDG 197
Cdd:pfam00028   4 SVPENAPVGTEVLTVTATDPDLGPNGRIFYSILgggPGGNFRID-PDTGD------ISTTKPLDRESIGEYELTVEATDS 76

                          90
                  ....*....|....*.
gi 1207117088 198 GRPPKSGTMEIIVDVL 213
Cdd:pfam00028  77 GGPPLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 10-109 1.52e-09

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 55.78  E-value: 1.52e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207117088  10 QIRYSVSEEQKDGAVVGNL-AKDLglDPRTLKERGFRIVSTSGDSLFTVNQNDGILSVNGKIDREvvceriSSCNINLKI 88
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVsATDP--DSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDRE------EQSSYTLTV 72

                          90       100
                  ....*....|....*....|....*.
gi 1207117088  89 -ALENPLEIHY----VSIEIVDVNDH 109
Cdd:cd11304    73 tATDGGGPPLSstatVTITVLDVNDN 98
Cadherin_C_2 pfam16492
Cadherin cytoplasmic C-terminal; Cadherin_C_2 is the cytoplasmic C-terminal domain of some ...
 671-725 2.60e-08

Cadherin cytoplasmic C-terminal; Cadherin_C_2 is the cytoplasmic C-terminal domain of some proto-cadherins. It is this region of the cadherins that allows cell-adhesion and the essential feature of metazoan multicellularity. Cadherins are cell-surface receptors that function in cell adhesion, cell polarity, and tissue morphogenesis.


Pssm-ID: 465139  Cd Length: 84  Bit Score: 51.76  E-value: 2.60e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1207117088 671 NVTFYLIITLGSVSVLFVISIIVLIVMQCSKS----TDYSSKYLQ-------DTNY-DGTLCHSIQY 725
Cdd:pfam16492   1 DLTFYLVIALASVSFLFLLFVIVLIALRLRRWrssaLLQSSGNLCsvpaphfPGNDgTGTLPQSYSY 67
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 44-111 6.13e-07

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 47.73  E-value: 6.13e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1207117088   44 FRIVSTSGDSLFTVNQNDGILSVNGKIDREVvcerISSCNINLKI--ALENPLE-IHYVSIEIVDVNDHAP 111
Cdd:smart00112  15 YSILSGNDDGLFSIDPETGEITTTKPLDREE----QPEYTLTVEAtdGGGPPLSsTATVTITVLDVNDNAP 81
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 11-109 1.41e-05

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 44.26  E-value: 1.41e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207117088  11 IRYSVSEEQKDGAVVGNLAKDLGldprTLKERGFRIVSTSGD---SLFTVNQNDGILSVNGKIDREVVCERI-----SSC 82
Cdd:cd00031     2 PDGSAVEGRSRGSFRVSIPTDLI----ASSGEIIKISAAGKEalpSWLHWEPHSGILEGLEKLDREDKGVHYisvsaASL 77

                          90       100
                  ....*....|....*....|....*..
gi 1207117088  83 NINlkiALENPLEIhyvSIEIVDVNDH 109
Cdd:cd00031    78 GAN---VPQTSSVF---SIEVYDENDN 98
Cadherin pfam00028
Cadherin domain;
14-74 4.61e-03

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 36.89  E-value: 4.61e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1207117088  14 SVSEEQKDGAVVGNLA---KDLGLDPRTlkerGFRIVSTSGDSLFTVNQNDGILSVNGKIDREV 74
Cdd:pfam00028   4 SVPENAPVGTEVLTVTatdPDLGPNGRI----FYSILGGGPGGNFRIDPDTGDISTTKPLDRES 63
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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