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Conserved domains on  [gi|1274110986|ref|XP_022820295|]
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uncharacterized protein LOC111352161 [Spodoptera litura]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 12822048)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 228-421 4.79e-12

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 66.59  E-value: 4.79e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274110986 228 KKMAVGYADTSIKIYNMETQEADVTYKVHKlrlqfipkklqrmhyGQVVALRAHPQKPFLfASGAWDKTLRIWDIRcQVG 307
Cdd:cd00200    22 KLLATGSGDGTIKVWDLETGELLRTLKGHT---------------GPVRDVAASADGTYL-ASGSSDKTIRLWDLE-TGE 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274110986 308 CVMTFEGV--DICSDAIDLNREHVLAGSWLPTdgVSVWDLTARKLLSFIK-----VQNRRPDVDGEYVYACrywrsyDYN 380
Cdd:cd00200    85 CVRTLTGHtsYVSSVAFSPDGRILSSSSRDKT--IKVWDVETGKCLTTLRghtdwVNSVAFSPDGTFVASS------SQD 156

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1274110986 381 RKGK-YALVGGSgtnSLEVINLHNRYITCSYPSP-GTILAVTS 421
Cdd:cd00200   157 GTIKlWDLRTGK---CVATLTGHTGEVNSVAFSPdGEKLLSSS 196
WD40 COG2319
WD40 repeat [General function prediction only];
95-303 2.57e-07

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 52.99  E-value: 2.57e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274110986  95 GFICSMAYSPDGETIIVGHSTGLIQMRHGSTGTVLCTLRNiqfPPKPVHALEYSSfESNVCYAACIDGavyRIEIPEIDT 174
Cdd:COG2319   247 GSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTG---HSGGVNSVAFSP-DGKLLASGSDDG---TVRLWDLAT 319

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274110986 175 sieepptfciradpmleslnmqfyGSPGTSLyaTPFVTQQRGAALS-LGvmsecKKMAVGYADTSIKIYNMETQEADVTY 253
Cdd:COG2319   320 ------------------------GKLLRTL--TGHTGAVRSVAFSpDG-----KTLASGSDDGTVRLWDLATGELLRTL 368

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1274110986 254 KVHKlrlqfipkklqrmhyGQVVALRAHPQKPFLfASGAWDKTLRIWDIR 303
Cdd:COG2319   369 TGHT---------------GAVTSVAFSPDGRTL-ASGSADGTVRLWDLA 402
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 228-421 4.79e-12

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 66.59  E-value: 4.79e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274110986 228 KKMAVGYADTSIKIYNMETQEADVTYKVHKlrlqfipkklqrmhyGQVVALRAHPQKPFLfASGAWDKTLRIWDIRcQVG 307
Cdd:cd00200    22 KLLATGSGDGTIKVWDLETGELLRTLKGHT---------------GPVRDVAASADGTYL-ASGSSDKTIRLWDLE-TGE 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274110986 308 CVMTFEGV--DICSDAIDLNREHVLAGSWLPTdgVSVWDLTARKLLSFIK-----VQNRRPDVDGEYVYACrywrsyDYN 380
Cdd:cd00200    85 CVRTLTGHtsYVSSVAFSPDGRILSSSSRDKT--IKVWDVETGKCLTTLRghtdwVNSVAFSPDGTFVASS------SQD 156

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1274110986 381 RKGK-YALVGGSgtnSLEVINLHNRYITCSYPSP-GTILAVTS 421
Cdd:cd00200   157 GTIKlWDLRTGK---CVATLTGHTGEVNSVAFSPdGEKLLSSS 196
WD40 COG2319
WD40 repeat [General function prediction only];
228-426 1.24e-07

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 53.76  E-value: 1.24e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274110986 228 KKMAVGYADTSIKIYNMETQEADVTYKVHKlrlqfipkklqrmhyGQVVALRAHPQKPFLfASGAWDKTLRIWDIRcQVG 307
Cdd:COG2319   175 KLLASGSDDGTVRLWDLATGKLLRTLTGHT---------------GAVRSVAFSPDGKLL-ASGSADGTVRLWDLA-TGK 237

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274110986 308 CVMTFEGVDICSDAIDL--NREHVLAGSWlptDG-VSVWDLTARKLLSFIKVQNRRpdvdgeyVYACRYwrSYDynrkGK 384
Cdd:COG2319   238 LLRTLTGHSGSVRSVAFspDGRLLASGSA---DGtVRLWDLATGELLRTLTGHSGG-------VNSVAF--SPD----GK 301

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1274110986 385 YaLVGGSGTNSLEVINLHNRYITCSYP-----------SP-GTILAVTSYQERI 426
Cdd:COG2319   302 L-LASGSDDGTVRLWDLATGKLLRTLTghtgavrsvafSPdGKTLASGSDDGTV 354
WD40 COG2319
WD40 repeat [General function prediction only];
95-303 2.57e-07

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 52.99  E-value: 2.57e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274110986  95 GFICSMAYSPDGETIIVGHSTGLIQMRHGSTGTVLCTLRNiqfPPKPVHALEYSSfESNVCYAACIDGavyRIEIPEIDT 174
Cdd:COG2319   247 GSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTG---HSGGVNSVAFSP-DGKLLASGSDDG---TVRLWDLAT 319

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274110986 175 sieepptfciradpmleslnmqfyGSPGTSLyaTPFVTQQRGAALS-LGvmsecKKMAVGYADTSIKIYNMETQEADVTY 253
Cdd:COG2319   320 ------------------------GKLLRTL--TGHTGAVRSVAFSpDG-----KTLASGSDDGTVRLWDLATGELLRTL 368

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1274110986 254 KVHKlrlqfipkklqrmhyGQVVALRAHPQKPFLfASGAWDKTLRIWDIR 303
Cdd:COG2319   369 TGHT---------------GAVTSVAFSPDGRTL-ASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 53-301 9.01e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 44.25  E-value: 9.01e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274110986  53 FITFAEKRLSISDITWLQDN-------YDRFFK--DTENKTLIEDhYLSECGFICSMAYSPDGETIIVGHSTGLIQMRHG 123
Cdd:cd00200    44 LRTLKGHTGPVRDVAASADGtylasgsSDKTIRlwDLETGECVRT-LTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDV 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274110986 124 STGTVLCTLRNIQfppKPVHALEYSSFeSNVCYAACIDGAV--YRIEIPEIDTSIE--EPPTFCIRADPMLESL------ 193
Cdd:cd00200   123 ETGKCLTTLRGHT---DWVNSVAFSPD-GTFVASSSQDGTIklWDLRTGKCVATLTghTGEVNSVAFSPDGEKLlssssd 198

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274110986 194 -NMQFYGSPGTSLYATpfVTQQRGAALSLGVMSECKKMAVGYADTSIKIYNMETQEADVTYKVHKlrlqfipkklqrmhy 272
Cdd:cd00200   199 gTIKLWDLSTGKCLGT--LRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHT--------------- 261

                         250       260
                  ....*....|....*....|....*....
gi 1274110986 273 GQVVALRAHPQKPFLfASGAWDKTLRIWD 301
Cdd:cd00200   262 NSVTSLAWSPDGKRL-ASGSADGTIRIWD 289
WD40 pfam00400
WD domain, G-beta repeat;
271-301 1.59e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.17  E-value: 1.59e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1274110986 271 HYGQVVALRAHPQKPFLfASGAWDKTLRIWD 301
Cdd:pfam00400  10 HTGSVTSLAFSPDGKLL-ASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 271-301 4.50e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 34.98  E-value: 4.50e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1274110986  271 HYGQVVALRAHPQKPFLfASGAWDKTLRIWD 301
Cdd:smart00320  11 HTGPVTSVAFSPDGKYL-ASGSDDGTIKLWD 40
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 228-421 4.79e-12

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 66.59  E-value: 4.79e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274110986 228 KKMAVGYADTSIKIYNMETQEADVTYKVHKlrlqfipkklqrmhyGQVVALRAHPQKPFLfASGAWDKTLRIWDIRcQVG 307
Cdd:cd00200    22 KLLATGSGDGTIKVWDLETGELLRTLKGHT---------------GPVRDVAASADGTYL-ASGSSDKTIRLWDLE-TGE 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274110986 308 CVMTFEGV--DICSDAIDLNREHVLAGSWLPTdgVSVWDLTARKLLSFIK-----VQNRRPDVDGEYVYACrywrsyDYN 380
Cdd:cd00200    85 CVRTLTGHtsYVSSVAFSPDGRILSSSSRDKT--IKVWDVETGKCLTTLRghtdwVNSVAFSPDGTFVASS------SQD 156

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1274110986 381 RKGK-YALVGGSgtnSLEVINLHNRYITCSYPSP-GTILAVTS 421
Cdd:cd00200   157 GTIKlWDLRTGK---CVATLTGHTGEVNSVAFSPdGEKLLSSS 196
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 95-351 4.68e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 60.43  E-value: 4.68e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274110986  95 GFICSMAYSPDGETIIVGHSTGLIQMRHGSTGTVLCTLRNiqfPPKPVHALEYSSFeSNVCYAACIDGAV--YRIEIPEI 172
Cdd:cd00200    10 GGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKG---HTGPVRDVAASAD-GTYLASGSSDKTIrlWDLETGEC 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274110986 173 DTSIE--EPPTFCIRADPMLESL-------NMQFY-GSPGTSLYATPFVTqqrGAALSLgVMSECKKM-AVGYADTSIKI 241
Cdd:cd00200    86 VRTLTghTSYVSSVAFSPDGRILssssrdkTIKVWdVETGKCLTTLRGHT---DWVNSV-AFSPDGTFvASSSQDGTIKL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274110986 242 YNMETQEADVTYKvhklrlqfipkklqrMHYGQVVALRAHPQKPFLFASGAwDKTLRIWDIRCQVgCVMTFEGVD--ICS 319
Cdd:cd00200   162 WDLRTGKCVATLT---------------GHTGEVNSVAFSPDGEKLLSSSS-DGTIKLWDLSTGK-CLGTLRGHEngVNS 224

                         250       260       270
                  ....*....|....*....|....*....|...
gi 1274110986 320 DAIDLNREHVLAGSwlpTDG-VSVWDLTARKLL 351
Cdd:cd00200   225 VAFSPDGYLLASGS---EDGtIRVWDLRTGECV 254
WD40 COG2319
WD40 repeat [General function prediction only];
228-426 1.24e-07

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 53.76  E-value: 1.24e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274110986 228 KKMAVGYADTSIKIYNMETQEADVTYKVHKlrlqfipkklqrmhyGQVVALRAHPQKPFLfASGAWDKTLRIWDIRcQVG 307
Cdd:COG2319   175 KLLASGSDDGTVRLWDLATGKLLRTLTGHT---------------GAVRSVAFSPDGKLL-ASGSADGTVRLWDLA-TGK 237

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274110986 308 CVMTFEGVDICSDAIDL--NREHVLAGSWlptDG-VSVWDLTARKLLSFIKVQNRRpdvdgeyVYACRYwrSYDynrkGK 384
Cdd:COG2319   238 LLRTLTGHSGSVRSVAFspDGRLLASGSA---DGtVRLWDLATGELLRTLTGHSGG-------VNSVAF--SPD----GK 301

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1274110986 385 YaLVGGSGTNSLEVINLHNRYITCSYP-----------SP-GTILAVTSYQERI 426
Cdd:COG2319   302 L-LASGSDDGTVRLWDLATGKLLRTLTghtgavrsvafSPdGKTLASGSDDGTV 354
WD40 COG2319
WD40 repeat [General function prediction only];
95-303 2.57e-07

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 52.99  E-value: 2.57e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274110986  95 GFICSMAYSPDGETIIVGHSTGLIQMRHGSTGTVLCTLRNiqfPPKPVHALEYSSfESNVCYAACIDGavyRIEIPEIDT 174
Cdd:COG2319   247 GSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTG---HSGGVNSVAFSP-DGKLLASGSDDG---TVRLWDLAT 319

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274110986 175 sieepptfciradpmleslnmqfyGSPGTSLyaTPFVTQQRGAALS-LGvmsecKKMAVGYADTSIKIYNMETQEADVTY 253
Cdd:COG2319   320 ------------------------GKLLRTL--TGHTGAVRSVAFSpDG-----KTLASGSDDGTVRLWDLATGELLRTL 368

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1274110986 254 KVHKlrlqfipkklqrmhyGQVVALRAHPQKPFLfASGAWDKTLRIWDIR 303
Cdd:COG2319   369 TGHT---------------GAVTSVAFSPDGRTL-ASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 228-344 3.55e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 48.87  E-value: 3.55e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274110986 228 KKMAVGYADTSIKIYNMETQEADVTYKVHKlrlqfipkklqrmhyGQVVALRAHPQKpFLFASGAWDKTLRIWDIRCQVg 307
Cdd:cd00200   190 EKLLSSSSDGTIKLWDLSTGKCLGTLRGHE---------------NGVNSVAFSPDG-YLLASGSEDGTIRVWDLRTGE- 252

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1274110986 308 CVMTFEGVD--ICSDAIDLNREHVLAGSWlptDG-VSVWD 344
Cdd:cd00200   253 CVQTLSGHTnsVTSLAWSPDGKRLASGSA---DGtIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
211-422 1.12e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 47.60  E-value: 1.12e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274110986 211 VTQQRGAALSLGVMSECKKMAVGYADTSIKIYNMETQEADVTYKVHKlrlqfipkklqrmhyGQVVALRAHPQKPFLfAS 290
Cdd:COG2319    74 LLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHT---------------GAVRSVAFSPDGKTL-AS 137

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274110986 291 GAWDKTLRIWDIRcQVGCVMTFEGVD--ICSDAIDLNREHVLAGSWlptDG-VSVWDLTARKLLsfikvqnRRPDVDGEY 367
Cdd:COG2319   138 GSADGTVRLWDLA-TGKLLRTLTGHSgaVTSVAFSPDGKLLASGSD---DGtVRLWDLATGKLL-------RTLTGHTGA 206

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1274110986 368 VYACRywrsydYNRKGKYaLVGGSGTNSLEVINL-----------HNRYITCSYPSP-GTILAVTSY 422
Cdd:COG2319   207 VRSVA------FSPDGKL-LASGSADGTVRLWDLatgkllrtltgHSGSVRSVAFSPdGRLLASGSA 266
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 53-301 9.01e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 44.25  E-value: 9.01e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274110986  53 FITFAEKRLSISDITWLQDN-------YDRFFK--DTENKTLIEDhYLSECGFICSMAYSPDGETIIVGHSTGLIQMRHG 123
Cdd:cd00200    44 LRTLKGHTGPVRDVAASADGtylasgsSDKTIRlwDLETGECVRT-LTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDV 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274110986 124 STGTVLCTLRNIQfppKPVHALEYSSFeSNVCYAACIDGAV--YRIEIPEIDTSIE--EPPTFCIRADPMLESL------ 193
Cdd:cd00200   123 ETGKCLTTLRGHT---DWVNSVAFSPD-GTFVASSSQDGTIklWDLRTGKCVATLTghTGEVNSVAFSPDGEKLlssssd 198

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274110986 194 -NMQFYGSPGTSLYATpfVTQQRGAALSLGVMSECKKMAVGYADTSIKIYNMETQEADVTYKVHKlrlqfipkklqrmhy 272
Cdd:cd00200   199 gTIKLWDLSTGKCLGT--LRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHT--------------- 261

                         250       260
                  ....*....|....*....|....*....
gi 1274110986 273 GQVVALRAHPQKPFLfASGAWDKTLRIWD 301
Cdd:cd00200   262 NSVTSLAWSPDGKRL-ASGSADGTIRIWD 289
WD40 pfam00400
WD domain, G-beta repeat;
271-301 1.59e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.17  E-value: 1.59e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1274110986 271 HYGQVVALRAHPQKPFLfASGAWDKTLRIWD 301
Cdd:pfam00400  10 HTGSVTSLAFSPDGKLL-ASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 271-301 4.50e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 34.98  E-value: 4.50e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1274110986  271 HYGQVVALRAHPQKPFLfASGAWDKTLRIWD 301
Cdd:smart00320  11 HTGPVTSVAFSPDGKYL-ASGSDDGTIKLWD 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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