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Conserved domains on  [gi|1338802186|ref|XP_023698433|]
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clathrin heavy chain 1-like isoform X2 [Paramormyrops kingsleyae]

Protein Classification

clathrin heavy chain( domain architecture ID 12019188)

clathrin heavy chain is a component of clathrin, the major protein of the polyhedral coat of coated pits and vesicles

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CLH smart00299
Clathrin heavy chain repeat homology;
1274-1416 1.17e-40

Clathrin heavy chain repeat homology;


:

Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 147.04  E-value: 1.17e-40
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1338802186  1274 LHIVVHADELEELINYYQDRGYFEELITMLEAALGLERAHMGMFTELAILYSKFKPQKMREHLELFWSRVNIPKVLRAAE 1353
Cdd:smart00299    1 LLEVSDPIDVSEVVELFEKRNLLEELIPYLESALKLNSENPALQTKLIELYAKYDPQKEIERLDNKSNHYDIEKVGKLCE 80

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1338802186  1354 QAHLWAELVFLYDKYEEYDNAIITMMNHPTDAwkeGQFKDIVTKVANVELYYRAIQFYLDFKP 1416
Cdd:smart00299   81 KAKLYEEAVELYKKDGNFKDAIVTLIEHLGNY---EKAIEYFVKQNNPELWAEVLKALLDKPR 140
CLH smart00299
Clathrin heavy chain repeat homology;
979-1118 1.45e-33

Clathrin heavy chain repeat homology;


:

Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 126.62  E-value: 1.45e-33
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1338802186   979 LSETQDPEEVSVTVKAFMTADLPNELIELLEKIVLDNSvfsEHRNLQNLLILTAIKADRTRVMEYISR-LDNYDAPDIAN 1057
Cdd:smart00299    1 LLEVSDPIDVSEVVELFEKRNLLEELIPYLESALKLNS---ENPALQTKLIELYAKYDPQKEIERLDNkSNHYDIEKVGK 77

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1338802186  1058 IAISNELFEEAFAIFRKFDVNTSAVQVLIEHIGNLDRAYEFAERCNEPAVWSQLGKAQLLK 1118
Cdd:smart00299   78 LCEKAKLYEEAVELYKKDGNFKDAIVTLIEHLGNYEKAIEYFVKQNNPELWAEVLKALLDK 138
CLH smart00299
Clathrin heavy chain repeat homology;
1128-1265 9.06e-32

Clathrin heavy chain repeat homology;


:

Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 121.61  E-value: 9.06e-32
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1338802186  1128 YIKADDPSAYMEVVQAANQSGNWEDLVKFLMMARKKARE-SYVETELIFALAKTNRLAELEEFINGPNNAHIQQVGDRCY 1206
Cdd:smart00299    1 LLEVSDPIDVSEVVELFEKRNLLEELIPYLESALKLNSEnPALQTKLIELYAKYDPQKEIERLDNKSNHYDIEKVGKLCE 80

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1338802186  1207 DEKMYDAAKLLYNNVSNFGRLASTLV-HLGEFQAAVDGARKANSTRTWKEVCFACVDGKE 1265
Cdd:smart00299   81 KAKLYEEAVELYKKDGNFKDAIVTLIeHLGNYEKAIEYFVKQNNPELWAEVLKALLDKPR 140
CLH smart00299
Clathrin heavy chain repeat homology;
686-824 8.09e-31

Clathrin heavy chain repeat homology;


:

Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 118.92  E-value: 8.09e-31
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1338802186   686 ASKYHEQLGTQALTDLFESFKSFEGLFYFLGSIVNF-SQDPEVHFKYIQAACKTGQIKEVERICRESNCYDAERVKNFLK 764
Cdd:smart00299    1 LLEVSDPIDVSEVVELFEKRNLLEELIPYLESALKLnSENPALQTKLIELYAKYDPQKEIERLDNKSNHYDIEKVGKLCE 80

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1338802186   765 EAKLTDQLPLIIVCDrFDFVHDLVLYLYR-NSLQKYIEIYVQKVNPSRLPVVIGGLLDVDC 824
Cdd:smart00299   81 KAKLYEEAVELYKKD-GNFKDAIVTLIEHlGNYEKAIEYFVKQNNPELWAEVLKALLDKPR 140
Clathrin_H_link pfam13838
Clathrin-H-link; This short domain is found on clathrins, and often appears on proteins ...
 356-421 2.55e-30

Clathrin-H-link; This short domain is found on clathrins, and often appears on proteins directly downstream from the Clathrin-link domain pfam09268.


:

Pssm-ID: 463995  Cd Length: 66  Bit Score: 114.61  E-value: 2.55e-30
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1338802186  356 NLAGAEELFARKFNNLFAGGSYSEAAKVAANAPKGILRTPDTIRRFQSVPAQPGQTSPLLQYFGIL 421
Cdd:pfam13838    1 GLPGADDLYFQQFNQLLNQGDYAEAAKVAANSPRGALRTPETIQRFKQLPAQPGQLSPILQYFGTL 66
CLH smart00299
Clathrin heavy chain repeat homology;
541-674 3.17e-30

Clathrin heavy chain repeat homology;


:

Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 116.99  E-value: 3.17e-30
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1338802186   541 EPLADITQIVDVFMEYNLIQQCTSFLLDALKNNrPTEGPLQTRLLEMNLMHAPQVADAILGNqMFTHYDRAHVAQLCEKS 620
Cdd:smart00299    5 SDPIDVSEVVELFEKRNLLEELIPYLESALKLN-SENPALQTKLIELYAKYDPQKEIERLDN-KSNHYDIEKVGKLCEKA 82

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 1338802186   621 GLLQRALEHYTDLYDIKRAVVHT--HLLNPEWLVNYFGS-LSVEDSLECLKAMLSAN 674
Cdd:smart00299   83 KLYEEAVELYKKDGNFKDAIVTLieHLGNYEKAIEYFVKqNNPELWAEVLKALLDKP 139
Clathrin pfam00637
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are ...
 1427-1564 6.05e-30

Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are composed of multiple alpha helical repeats. They occur in the arm region of the Clathrin heavy chain.


:

Pssm-ID: 459884 [Multi-domain]  Cd Length: 142  Bit Score: 116.59  E-value: 6.05e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1338802186 1427 SPRLDHTRAVNFFTKMKQIPLVKPYLRSVQN---HNNKSVNEALNNLLIIEEDFQALRTSIDAYDNFDNISLAQSLEKHE 1503
Cdd:pfam00637    5 TDPIDVSRVVKLFEKAGLLEELISYLESALKedsRENPALQTALIELYAKYDDPEELEEFLKKNNNYDLEKVAKLCEKAD 84

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1338802186 1504 LIEFRRiaaYLFKGNNRWKQSIELCKKDQLYKDAMQYAAESKDIEVAEELLQWFLQEDKKE 1564
Cdd:pfam00637   85 LYEEAV---ILYKKIGNWKEAISLLKKLGDYKDAIEYAVKSSNPELWEELLEALLDNGRFE 142
CLH smart00299
Clathrin heavy chain repeat homology;
833-968 1.16e-28

Clathrin heavy chain repeat homology;


:

Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 112.75  E-value: 1.16e-28
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1338802186   833 IMVVRGQFSTDELVAEVEKRNRLKLLLPWLEGRIHEGCEEPATHNALAKIYIDSNNNP--ERFLKENPYYDSRVVGKYCE 910
Cdd:smart00299    1 LLEVSDPIDVSEVVELFEKRNLLEELIPYLESALKLNSENPALQTKLIELYAKYDPQKeiERLDNKSNHYDIEKVGKLCE 80

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1338802186   911 KRDPH-LACVAYERGQCDQELIHVCNENS-LFKSLSRYLVRRKDHDLWGSVLLESNPYRR 968
Cdd:smart00299   81 KAKLYeEAVELYKKDGNFKDAIVTLIEHLgNYEKAIEYFVKQNNPELWAEVLKALLDKPR 140
Clathrin-link pfam09268
Clathrin, heavy-chain linker; Members of this family adopt a structure consisting of ...
 331-354 2.96e-09

Clathrin, heavy-chain linker; Members of this family adopt a structure consisting of alpha-alpha superhelix. They are predominantly found in clathrin, where they act as a heavy-chain linker domain.


:

Pssm-ID: 462732  Cd Length: 24  Bit Score: 53.60  E-value: 2.96e-09
                           10        20
                   ....*....|....*....|....
gi 1338802186  331 EENIIPYITNVLQNSDLALRMAVR 354
Cdd:pfam09268    1 EDNIIPYILNTLQNPDLALRLASR 24
Clathrin_propel pfam01394
Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that ...
 198-234 3.33e-07

Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that surrounds coated vesicles. The soluble assembly unit, a triskelion, contains three heavy chains and three light chains in an extended three-legged structure. Each leg contains one heavy and one light chain. The N-terminus of the heavy chain is known as the globular domain, and is composed of seven repeats which form a beta propeller.


:

Pssm-ID: 460192  Cd Length: 37  Bit Score: 48.18  E-value: 3.33e-07
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1338802186  198 AASFAQFKMEGNAEESTLFCFAVRGQAGGKLHIIEVG 234
Cdd:pfam01394    1 NAISAIIIFPTATMESWLFIIAINGTKKGQVQIVDVE 37
Clathrin_propel pfam01394
Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that ...
 19-56 5.46e-05

Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that surrounds coated vesicles. The soluble assembly unit, a triskelion, contains three heavy chains and three light chains in an extended three-legged structure. Each leg contains one heavy and one light chain. The N-terminus of the heavy chain is known as the globular domain, and is composed of seven repeats which form a beta propeller.


:

Pssm-ID: 460192  Cd Length: 37  Bit Score: 41.63  E-value: 5.46e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1338802186   19 GINPANIGFSTLTMESDKFICIREKVGeQAQVVIIDMN 56
Cdd:pfam01394    1 NAISAIIIFPTATMESWLFIIAINGTK-KGQVQIVDVE 37
Clathrin_propel pfam01394
Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that ...
 256-288 9.47e-05

Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that surrounds coated vesicles. The soluble assembly unit, a triskelion, contains three heavy chains and three light chains in an extended three-legged structure. Each leg contains one heavy and one light chain. The N-terminus of the heavy chain is known as the globular domain, and is composed of seven repeats which form a beta propeller.


:

Pssm-ID: 460192  Cd Length: 37  Bit Score: 41.25  E-value: 9.47e-05
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1338802186  256 AQNDFPVAMQISSKQDVVFLITKYGYIHLYDLE 288
Cdd:pfam01394    5 AIIIFPTATMESWLFIIAINGTKKGQVQIVDVE 37
Clathrin_propel pfam01394
Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that ...
 296-330 2.16e-04

Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that surrounds coated vesicles. The soluble assembly unit, a triskelion, contains three heavy chains and three light chains in an extended three-legged structure. Each leg contains one heavy and one light chain. The N-terminus of the heavy chain is known as the globular domain, and is composed of seven repeats which form a beta propeller.


:

Pssm-ID: 460192  Cd Length: 37  Bit Score: 40.09  E-value: 2.16e-04
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1338802186  296 NRISGETIFVTAPHEATAGIIGVN--RKGQVLSVCVE 330
Cdd:pfam01394    1 NAISAIIIFPTATMESWLFIIAINgtKKGQVQIVDVE 37
Clathrin_propel pfam01394
Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that ...
 148-187 3.30e-04

Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that surrounds coated vesicles. The soluble assembly unit, a triskelion, contains three heavy chains and three light chains in an extended three-legged structure. Each leg contains one heavy and one light chain. The N-terminus of the heavy chain is known as the globular domain, and is composed of seven repeats which form a beta propeller.


:

Pssm-ID: 460192  Cd Length: 37  Bit Score: 39.71  E-value: 3.30e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1338802186  148 LAGCQIINYRTDAKQKWLLLIGISaqqNRVVGAMQLYSVD 187
Cdd:pfam01394    1 NAISAIIIFPTATMESWLFIIAIN---GTKKGQVQIVDVE 37
 
Name Accession Description Interval E-value
CLH smart00299
Clathrin heavy chain repeat homology;
1274-1416 1.17e-40

Clathrin heavy chain repeat homology;


Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 147.04  E-value: 1.17e-40
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1338802186  1274 LHIVVHADELEELINYYQDRGYFEELITMLEAALGLERAHMGMFTELAILYSKFKPQKMREHLELFWSRVNIPKVLRAAE 1353
Cdd:smart00299    1 LLEVSDPIDVSEVVELFEKRNLLEELIPYLESALKLNSENPALQTKLIELYAKYDPQKEIERLDNKSNHYDIEKVGKLCE 80

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1338802186  1354 QAHLWAELVFLYDKYEEYDNAIITMMNHPTDAwkeGQFKDIVTKVANVELYYRAIQFYLDFKP 1416
Cdd:smart00299   81 KAKLYEEAVELYKKDGNFKDAIVTLIEHLGNY---EKAIEYFVKQNNPELWAEVLKALLDKPR 140
CLH smart00299
Clathrin heavy chain repeat homology;
979-1118 1.45e-33

Clathrin heavy chain repeat homology;


Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 126.62  E-value: 1.45e-33
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1338802186   979 LSETQDPEEVSVTVKAFMTADLPNELIELLEKIVLDNSvfsEHRNLQNLLILTAIKADRTRVMEYISR-LDNYDAPDIAN 1057
Cdd:smart00299    1 LLEVSDPIDVSEVVELFEKRNLLEELIPYLESALKLNS---ENPALQTKLIELYAKYDPQKEIERLDNkSNHYDIEKVGK 77

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1338802186  1058 IAISNELFEEAFAIFRKFDVNTSAVQVLIEHIGNLDRAYEFAERCNEPAVWSQLGKAQLLK 1118
Cdd:smart00299   78 LCEKAKLYEEAVELYKKDGNFKDAIVTLIEHLGNYEKAIEYFVKQNNPELWAEVLKALLDK 138
CLH smart00299
Clathrin heavy chain repeat homology;
1128-1265 9.06e-32

Clathrin heavy chain repeat homology;


Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 121.61  E-value: 9.06e-32
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1338802186  1128 YIKADDPSAYMEVVQAANQSGNWEDLVKFLMMARKKARE-SYVETELIFALAKTNRLAELEEFINGPNNAHIQQVGDRCY 1206
Cdd:smart00299    1 LLEVSDPIDVSEVVELFEKRNLLEELIPYLESALKLNSEnPALQTKLIELYAKYDPQKEIERLDNKSNHYDIEKVGKLCE 80

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1338802186  1207 DEKMYDAAKLLYNNVSNFGRLASTLV-HLGEFQAAVDGARKANSTRTWKEVCFACVDGKE 1265
Cdd:smart00299   81 KAKLYEEAVELYKKDGNFKDAIVTLIeHLGNYEKAIEYFVKQNNPELWAEVLKALLDKPR 140
Clathrin pfam00637
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are ...
 979-1119 5.42e-31

Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are composed of multiple alpha helical repeats. They occur in the arm region of the Clathrin heavy chain.


Pssm-ID: 459884 [Multi-domain]  Cd Length: 142  Bit Score: 119.28  E-value: 5.42e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1338802186  979 LSETQDPEEVSVTVKAFMTADLPNELIELLEKIVLDNSvfSEHRNLQNLLILTAIKADR-TRVMEYISRLDNYDAPDIAN 1057
Cdd:pfam00637    1 LIESTDPIDVSRVVKLFEKAGLLEELISYLESALKEDS--RENPALQTALIELYAKYDDpEELEEFLKKNNNYDLEKVAK 78

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1338802186 1058 IAISNELFEEAFAIFRKFDVNTSAVqVLIEHIGNLDRAYEFAERCNEPAVWSQLGKAQLLKG 1119
Cdd:pfam00637   79 LCEKADLYEEAVILYKKIGNWKEAI-SLLKKLGDYKDAIEYAVKSSNPELWEELLEALLDNG 139
CLH smart00299
Clathrin heavy chain repeat homology;
686-824 8.09e-31

Clathrin heavy chain repeat homology;


Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 118.92  E-value: 8.09e-31
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1338802186   686 ASKYHEQLGTQALTDLFESFKSFEGLFYFLGSIVNF-SQDPEVHFKYIQAACKTGQIKEVERICRESNCYDAERVKNFLK 764
Cdd:smart00299    1 LLEVSDPIDVSEVVELFEKRNLLEELIPYLESALKLnSENPALQTKLIELYAKYDPQKEIERLDNKSNHYDIEKVGKLCE 80

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1338802186   765 EAKLTDQLPLIIVCDrFDFVHDLVLYLYR-NSLQKYIEIYVQKVNPSRLPVVIGGLLDVDC 824
Cdd:smart00299   81 KAKLYEEAVELYKKD-GNFKDAIVTLIEHlGNYEKAIEYFVKQNNPELWAEVLKALLDKPR 140
Clathrin_H_link pfam13838
Clathrin-H-link; This short domain is found on clathrins, and often appears on proteins ...
 356-421 2.55e-30

Clathrin-H-link; This short domain is found on clathrins, and often appears on proteins directly downstream from the Clathrin-link domain pfam09268.


Pssm-ID: 463995  Cd Length: 66  Bit Score: 114.61  E-value: 2.55e-30
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1338802186  356 NLAGAEELFARKFNNLFAGGSYSEAAKVAANAPKGILRTPDTIRRFQSVPAQPGQTSPLLQYFGIL 421
Cdd:pfam13838    1 GLPGADDLYFQQFNQLLNQGDYAEAAKVAANSPRGALRTPETIQRFKQLPAQPGQLSPILQYFGTL 66
CLH smart00299
Clathrin heavy chain repeat homology;
541-674 3.17e-30

Clathrin heavy chain repeat homology;


Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 116.99  E-value: 3.17e-30
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1338802186   541 EPLADITQIVDVFMEYNLIQQCTSFLLDALKNNrPTEGPLQTRLLEMNLMHAPQVADAILGNqMFTHYDRAHVAQLCEKS 620
Cdd:smart00299    5 SDPIDVSEVVELFEKRNLLEELIPYLESALKLN-SENPALQTKLIELYAKYDPQKEIERLDN-KSNHYDIEKVGKLCEKA 82

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 1338802186   621 GLLQRALEHYTDLYDIKRAVVHT--HLLNPEWLVNYFGS-LSVEDSLECLKAMLSAN 674
Cdd:smart00299   83 KLYEEAVELYKKDGNFKDAIVTLieHLGNYEKAIEYFVKqNNPELWAEVLKALLDKP 139
Clathrin pfam00637
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are ...
 1128-1267 4.23e-30

Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are composed of multiple alpha helical repeats. They occur in the arm region of the Clathrin heavy chain.


Pssm-ID: 459884 [Multi-domain]  Cd Length: 142  Bit Score: 116.97  E-value: 4.23e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1338802186 1128 YIKADDPSAYMEVVQAANQSGNWEDLVKFLMMARKKARE--SYVETELIFALAKTNRLAELEEFINGPNNAHIQQVGDRC 1205
Cdd:pfam00637    1 LIESTDPIDVSRVVKLFEKAGLLEELISYLESALKEDSRenPALQTALIELYAKYDDPEELEEFLKKNNNYDLEKVAKLC 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1338802186 1206 YDEKMYDAAKLLYNNVSNFGRLASTLVHLGEFQAAVDGARKANSTRTWKEVCFACVDGKEFR 1267
Cdd:pfam00637   81 EKADLYEEAVILYKKIGNWKEAISLLKKLGDYKDAIEYAVKSSNPELWEELLEALLDNGRFE 142
Clathrin pfam00637
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are ...
 1427-1564 6.05e-30

Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are composed of multiple alpha helical repeats. They occur in the arm region of the Clathrin heavy chain.


Pssm-ID: 459884 [Multi-domain]  Cd Length: 142  Bit Score: 116.59  E-value: 6.05e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1338802186 1427 SPRLDHTRAVNFFTKMKQIPLVKPYLRSVQN---HNNKSVNEALNNLLIIEEDFQALRTSIDAYDNFDNISLAQSLEKHE 1503
Cdd:pfam00637    5 TDPIDVSRVVKLFEKAGLLEELISYLESALKedsRENPALQTALIELYAKYDDPEELEEFLKKNNNYDLEKVAKLCEKAD 84

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1338802186 1504 LIEFRRiaaYLFKGNNRWKQSIELCKKDQLYKDAMQYAAESKDIEVAEELLQWFLQEDKKE 1564
Cdd:pfam00637   85 LYEEAV---ILYKKIGNWKEAISLLKKLGDYKDAIEYAVKSSNPELWEELLEALLDNGRFE 142
CLH smart00299
Clathrin heavy chain repeat homology;
833-968 1.16e-28

Clathrin heavy chain repeat homology;


Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 112.75  E-value: 1.16e-28
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1338802186   833 IMVVRGQFSTDELVAEVEKRNRLKLLLPWLEGRIHEGCEEPATHNALAKIYIDSNNNP--ERFLKENPYYDSRVVGKYCE 910
Cdd:smart00299    1 LLEVSDPIDVSEVVELFEKRNLLEELIPYLESALKLNSENPALQTKLIELYAKYDPQKeiERLDNKSNHYDIEKVGKLCE 80

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1338802186   911 KRDPH-LACVAYERGQCDQELIHVCNENS-LFKSLSRYLVRRKDHDLWGSVLLESNPYRR 968
Cdd:smart00299   81 KAKLYeEAVELYKKDGNFKDAIVTLIEHLgNYEKAIEYFVKQNNPELWAEVLKALLDKPR 140
Clathrin pfam00637
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are ...
 1274-1416 2.63e-27

Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are composed of multiple alpha helical repeats. They occur in the arm region of the Clathrin heavy chain.


Pssm-ID: 459884 [Multi-domain]  Cd Length: 142  Bit Score: 108.88  E-value: 2.63e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1338802186 1274 LHIVVHADELEELINYYQDRGYFEELITMLEAALGL-ERAHMGMFTELAILYSKF-KPQKMREHLELFWSrVNIPKVLRA 1351
Cdd:pfam00637    1 LIESTDPIDVSRVVKLFEKAGLLEELISYLESALKEdSRENPALQTALIELYAKYdDPEELEEFLKKNNN-YDLEKVAKL 79

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1338802186 1352 AEQAHLWAELVFLYDKYEEYDNAIitMMNHPTDAWKEGQfkDIVTKVANVELYYRAIQFYLDFKP 1416
Cdd:pfam00637   80 CEKADLYEEAVILYKKIGNWKEAI--SLLKKLGDYKDAI--EYAVKSSNPELWEELLEALLDNGR 140
Clathrin pfam00637
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are ...
 688-826 1.94e-25

Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are composed of multiple alpha helical repeats. They occur in the arm region of the Clathrin heavy chain.


Pssm-ID: 459884 [Multi-domain]  Cd Length: 142  Bit Score: 103.49  E-value: 1.94e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1338802186  688 KYHEQLGTQALTDLFESFKSFEGLFYFLGSIVNFS--QDPEVHFKYIQAACKTGQIKEVERICRESNCYDAERVKNFLKE 765
Cdd:pfam00637    3 ESTDPIDVSRVVKLFEKAGLLEELISYLESALKEDsrENPALQTALIELYAKYDDPEELEEFLKKNNNYDLEKVAKLCEK 82

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1338802186  766 AKLTDQLPLIIVCdrFDFVHDLV-LYLYRNSLQKYIEIYVQKVNPSRLPVVIGGLLDVDCSE 826
Cdd:pfam00637   83 ADLYEEAVILYKK--IGNWKEAIsLLKKLGDYKDAIEYAVKSSNPELWEELLEALLDNGRFE 142
Clathrin pfam00637
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are ...
 843-970 3.54e-25

Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are composed of multiple alpha helical repeats. They occur in the arm region of the Clathrin heavy chain.


Pssm-ID: 459884 [Multi-domain]  Cd Length: 142  Bit Score: 102.72  E-value: 3.54e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1338802186  843 DELVAEVEKRNRLKLLLPWLEGRIHEG-CEEPATHNALAKIYIDSN--NNPERFLKENPYYDSRVVGKYCEKRDPH-LAC 918
Cdd:pfam00637   11 SRVVKLFEKAGLLEELISYLESALKEDsRENPALQTALIELYAKYDdpEELEEFLKKNNNYDLEKVAKLCEKADLYeEAV 90

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1338802186  919 VAYERGQCDQELIHVCNENSLFKSLSRYLVRRKDHDLWGSVLLESNPYRRPL 970
Cdd:pfam00637   91 ILYKKIGNWKEAISLLKKLGDYKDAIEYAVKSSNPELWEELLEALLDNGRFE 142
Clathrin pfam00637
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are ...
 541-678 2.23e-24

Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are composed of multiple alpha helical repeats. They occur in the arm region of the Clathrin heavy chain.


Pssm-ID: 459884 [Multi-domain]  Cd Length: 142  Bit Score: 100.41  E-value: 2.23e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1338802186  541 EPLADITQIVDVFMEYNLIQQCTSFLLDALKNNRPTEGPLQTRLLEMNLMHAP-QVADAILgnQMFTHYDRAHVAQLCEK 619
Cdd:pfam00637    5 TDPIDVSRVVKLFEKAGLLEELISYLESALKEDSRENPALQTALIELYAKYDDpEELEEFL--KKNNNYDLEKVAKLCEK 82

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1338802186  620 SGLLQRALEHYTDLYDIKRAV-VHTHLLNPEWLVNYFGSLSVEDSLECLKAMLSANIRQN 678
Cdd:pfam00637   83 ADLYEEAVILYKKIGNWKEAIsLLKKLGDYKDAIEYAVKSSNPELWEELLEALLDNGRFE 142
CLH smart00299
Clathrin heavy chain repeat homology;
1427-1578 3.10e-23

Clathrin heavy chain repeat homology;


Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 96.96  E-value: 3.10e-23
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1338802186  1427 SPRLDHTRAVNFFTKMKQIPLVKPYLRSVQNHNnkSVNEALNNLLIIEEDFQALRTSIDAYDNFdnislaqslekHELIE 1506
Cdd:smart00299    5 SDPIDVSEVVELFEKRNLLEELIPYLESALKLN--SENPALQTKLIELYAKYDPQKEIERLDNK-----------SNHYD 71

                            90       100       110       120       130       140       150
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1338802186  1507 FRRIAAYLFKGNNrWKQSIELCKKDQLYKDAMQYAaeSKDIEVAEELLQWFLQEDKKECFAACLFTCYDLLR 1578
Cdd:smart00299   72 IEKVGKLCEKAKL-YEEAVELYKKDGNFKDAIVTL--IEHLGNYEKAIEYFVKQNNPELWAEVLKALLDKPR 140
Clathrin-link pfam09268
Clathrin, heavy-chain linker; Members of this family adopt a structure consisting of ...
 331-354 2.96e-09

Clathrin, heavy-chain linker; Members of this family adopt a structure consisting of alpha-alpha superhelix. They are predominantly found in clathrin, where they act as a heavy-chain linker domain.


Pssm-ID: 462732  Cd Length: 24  Bit Score: 53.60  E-value: 2.96e-09
                           10        20
                   ....*....|....*....|....
gi 1338802186  331 EENIIPYITNVLQNSDLALRMAVR 354
Cdd:pfam09268    1 EDNIIPYILNTLQNPDLALRLASR 24
Clathrin_propel pfam01394
Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that ...
 198-234 3.33e-07

Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that surrounds coated vesicles. The soluble assembly unit, a triskelion, contains three heavy chains and three light chains in an extended three-legged structure. Each leg contains one heavy and one light chain. The N-terminus of the heavy chain is known as the globular domain, and is composed of seven repeats which form a beta propeller.


Pssm-ID: 460192  Cd Length: 37  Bit Score: 48.18  E-value: 3.33e-07
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1338802186  198 AASFAQFKMEGNAEESTLFCFAVRGQAGGKLHIIEVG 234
Cdd:pfam01394    1 NAISAIIIFPTATMESWLFIIAINGTKKGQVQIVDVE 37
Clathrin_propel pfam01394
Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that ...
 19-56 5.46e-05

Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that surrounds coated vesicles. The soluble assembly unit, a triskelion, contains three heavy chains and three light chains in an extended three-legged structure. Each leg contains one heavy and one light chain. The N-terminus of the heavy chain is known as the globular domain, and is composed of seven repeats which form a beta propeller.


Pssm-ID: 460192  Cd Length: 37  Bit Score: 41.63  E-value: 5.46e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1338802186   19 GINPANIGFSTLTMESDKFICIREKVGeQAQVVIIDMN 56
Cdd:pfam01394    1 NAISAIIIFPTATMESWLFIIAINGTK-KGQVQIVDVE 37
Clathrin_propel pfam01394
Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that ...
 256-288 9.47e-05

Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that surrounds coated vesicles. The soluble assembly unit, a triskelion, contains three heavy chains and three light chains in an extended three-legged structure. Each leg contains one heavy and one light chain. The N-terminus of the heavy chain is known as the globular domain, and is composed of seven repeats which form a beta propeller.


Pssm-ID: 460192  Cd Length: 37  Bit Score: 41.25  E-value: 9.47e-05
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1338802186  256 AQNDFPVAMQISSKQDVVFLITKYGYIHLYDLE 288
Cdd:pfam01394    5 AIIIFPTATMESWLFIIAINGTKKGQVQIVDVE 37
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 1056-1247 1.86e-04

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 45.11  E-value: 1.86e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1338802186 1056 ANIAISNELFEEAFAIFRK-FDVNTSAVQVLI------EHIGNLDRAYEFAERC-----NEPAVWSQLGKAQLLKGLVKE 1123
Cdd:COG2956     15 GLNYLLNGQPDKAIDLLEEaLELDPETVEAHLalgnlyRRRGEYDRAIRIHQKLlerdpDRAEALLELAQDYLKAGLLDR 94

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1338802186 1124 AIDSYIKA-----DDPSAYMEVVQAANQSGNWEDLVKFL-MMARKKARESYVETELIFALAKTNRLAE----LEEFING- 1192
Cdd:COG2956     95 AEELLEKLleldpDDAEALRLLAEIYEQEGDWEKAIEVLeRLLKLGPENAHAYCELAELYLEQGDYDEaieaLEKALKLd 174

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1338802186 1193 PNNAHIQ-QVGDRCYDEKMYDAAKLLY--------NNVSNFGRLASTLVHLGEFQAAVDGARKA 1247
Cdd:COG2956    175 PDCARALlLLAELYLEQGDYEEAIAALeraleqdpDYLPALPRLAELYEKLGDPEEALELLRKA 238
Clathrin_propel pfam01394
Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that ...
 296-330 2.16e-04

Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that surrounds coated vesicles. The soluble assembly unit, a triskelion, contains three heavy chains and three light chains in an extended three-legged structure. Each leg contains one heavy and one light chain. The N-terminus of the heavy chain is known as the globular domain, and is composed of seven repeats which form a beta propeller.


Pssm-ID: 460192  Cd Length: 37  Bit Score: 40.09  E-value: 2.16e-04
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1338802186  296 NRISGETIFVTAPHEATAGIIGVN--RKGQVLSVCVE 330
Cdd:pfam01394    1 NAISAIIIFPTATMESWLFIIAINgtKKGQVQIVDVE 37
Clathrin_propel pfam01394
Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that ...
 148-187 3.30e-04

Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that surrounds coated vesicles. The soluble assembly unit, a triskelion, contains three heavy chains and three light chains in an extended three-legged structure. Each leg contains one heavy and one light chain. The N-terminus of the heavy chain is known as the globular domain, and is composed of seven repeats which form a beta propeller.


Pssm-ID: 460192  Cd Length: 37  Bit Score: 39.71  E-value: 3.30e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1338802186  148 LAGCQIINYRTDAKQKWLLLIGISaqqNRVVGAMQLYSVD 187
Cdd:pfam01394    1 NAISAIIIFPTATMESWLFIIAIN---GTKKGQVQIVDVE 37
Coatomer_WDAD_beta-like cd22947
Coatomer WD Associated Region from Coatomer Subunit Beta and Beta'; Coatomer subunit beta', ...
 1061-1185 5.17e-04

Coatomer WD Associated Region from Coatomer Subunit Beta and Beta'; Coatomer subunit beta', also called beta'-coat protein; beta'-COP; p102, is a component of the coatomer, which is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complexes are hetero-oligomers composed of at least an alpha, beta, beta', gamma, delta, epsilon and zeta subunit. It is a heptameric complex that can polymerize into a cage to deform the membrane into a bud. This model corresponds to the WD-associated (WDAD) region found in coatomer subunits beta and beta' and is composed of a beta-propeller and an alpha-solenoid. The WD40 domain is found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly. It typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40. Between the GH and WD lies a conserved core. It forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet. Each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade. The last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure. The residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands allowing them to bind either stably or reversibly.


Pssm-ID: 438572  Cd Length: 475  Bit Score: 44.77  E-value: 5.17e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1338802186 1061 SNELFEEAFAIFR----KFDVntsAVQvliehIGNLDRAYEFAERCNEPAVWSQLGKAQLLKGLVKEAIDSYIKADDPSA 1136
Cdd:cd22947    324 SQGLKELALEVSTdpdhKFEL---ALQ-----LGDLDLALEIARESESESKWKQLGDLALSKGDFDLAEECLKKAGDLSG 395

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1338802186 1137 YMEVVQAanqSGNWEDLVKFLMMARKK-----ARESYVET----ELIFALAKTNRLAE 1185
Cdd:cd22947    396 LLLLYSS---TGDKEGLEELAELAEAAgknniAFLAYFLLgdldKCVDLLIKTGRLPE 450
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 1054-1186 2.40e-03

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 42.67  E-value: 2.40e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1338802186 1054 DIANIAISNELFEEAFAIFRKF-DVNTSAVQVLI------EHIGNLDRAYEFAERC-----NEPAVWSQLGKAQLLKGLV 1121
Cdd:COG3914    117 NLGNLLLALGRLEEALAALRRAlALNPDFAEAYLnlgealRRLGRLEEAIAALRRAleldpDNAEALNNLGNALQDLGRL 196

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1338802186 1122 KEAIDSYIKA-----DDPSAYMEVVQAANQSGNWEDLVKFLMMARKKARESYVETELIFALAKTNRLAEL 1186
Cdd:COG3914    197 EEAIAAYRRAleldpDNADAHSNLLFALRQACDWEVYDRFEELLAALARGPSELSPFALLYLPDDDPAEL 266
 
Name Accession Description Interval E-value
CLH smart00299
Clathrin heavy chain repeat homology;
1274-1416 1.17e-40

Clathrin heavy chain repeat homology;


Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 147.04  E-value: 1.17e-40
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1338802186  1274 LHIVVHADELEELINYYQDRGYFEELITMLEAALGLERAHMGMFTELAILYSKFKPQKMREHLELFWSRVNIPKVLRAAE 1353
Cdd:smart00299    1 LLEVSDPIDVSEVVELFEKRNLLEELIPYLESALKLNSENPALQTKLIELYAKYDPQKEIERLDNKSNHYDIEKVGKLCE 80

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1338802186  1354 QAHLWAELVFLYDKYEEYDNAIITMMNHPTDAwkeGQFKDIVTKVANVELYYRAIQFYLDFKP 1416
Cdd:smart00299   81 KAKLYEEAVELYKKDGNFKDAIVTLIEHLGNY---EKAIEYFVKQNNPELWAEVLKALLDKPR 140
CLH smart00299
Clathrin heavy chain repeat homology;
979-1118 1.45e-33

Clathrin heavy chain repeat homology;


Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 126.62  E-value: 1.45e-33
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1338802186   979 LSETQDPEEVSVTVKAFMTADLPNELIELLEKIVLDNSvfsEHRNLQNLLILTAIKADRTRVMEYISR-LDNYDAPDIAN 1057
Cdd:smart00299    1 LLEVSDPIDVSEVVELFEKRNLLEELIPYLESALKLNS---ENPALQTKLIELYAKYDPQKEIERLDNkSNHYDIEKVGK 77

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1338802186  1058 IAISNELFEEAFAIFRKFDVNTSAVQVLIEHIGNLDRAYEFAERCNEPAVWSQLGKAQLLK 1118
Cdd:smart00299   78 LCEKAKLYEEAVELYKKDGNFKDAIVTLIEHLGNYEKAIEYFVKQNNPELWAEVLKALLDK 138
CLH smart00299
Clathrin heavy chain repeat homology;
1128-1265 9.06e-32

Clathrin heavy chain repeat homology;


Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 121.61  E-value: 9.06e-32
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1338802186  1128 YIKADDPSAYMEVVQAANQSGNWEDLVKFLMMARKKARE-SYVETELIFALAKTNRLAELEEFINGPNNAHIQQVGDRCY 1206
Cdd:smart00299    1 LLEVSDPIDVSEVVELFEKRNLLEELIPYLESALKLNSEnPALQTKLIELYAKYDPQKEIERLDNKSNHYDIEKVGKLCE 80

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1338802186  1207 DEKMYDAAKLLYNNVSNFGRLASTLV-HLGEFQAAVDGARKANSTRTWKEVCFACVDGKE 1265
Cdd:smart00299   81 KAKLYEEAVELYKKDGNFKDAIVTLIeHLGNYEKAIEYFVKQNNPELWAEVLKALLDKPR 140
Clathrin pfam00637
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are ...
 979-1119 5.42e-31

Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are composed of multiple alpha helical repeats. They occur in the arm region of the Clathrin heavy chain.


Pssm-ID: 459884 [Multi-domain]  Cd Length: 142  Bit Score: 119.28  E-value: 5.42e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1338802186  979 LSETQDPEEVSVTVKAFMTADLPNELIELLEKIVLDNSvfSEHRNLQNLLILTAIKADR-TRVMEYISRLDNYDAPDIAN 1057
Cdd:pfam00637    1 LIESTDPIDVSRVVKLFEKAGLLEELISYLESALKEDS--RENPALQTALIELYAKYDDpEELEEFLKKNNNYDLEKVAK 78

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1338802186 1058 IAISNELFEEAFAIFRKFDVNTSAVqVLIEHIGNLDRAYEFAERCNEPAVWSQLGKAQLLKG 1119
Cdd:pfam00637   79 LCEKADLYEEAVILYKKIGNWKEAI-SLLKKLGDYKDAIEYAVKSSNPELWEELLEALLDNG 139
CLH smart00299
Clathrin heavy chain repeat homology;
686-824 8.09e-31

Clathrin heavy chain repeat homology;


Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 118.92  E-value: 8.09e-31
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1338802186   686 ASKYHEQLGTQALTDLFESFKSFEGLFYFLGSIVNF-SQDPEVHFKYIQAACKTGQIKEVERICRESNCYDAERVKNFLK 764
Cdd:smart00299    1 LLEVSDPIDVSEVVELFEKRNLLEELIPYLESALKLnSENPALQTKLIELYAKYDPQKEIERLDNKSNHYDIEKVGKLCE 80

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1338802186   765 EAKLTDQLPLIIVCDrFDFVHDLVLYLYR-NSLQKYIEIYVQKVNPSRLPVVIGGLLDVDC 824
Cdd:smart00299   81 KAKLYEEAVELYKKD-GNFKDAIVTLIEHlGNYEKAIEYFVKQNNPELWAEVLKALLDKPR 140
Clathrin_H_link pfam13838
Clathrin-H-link; This short domain is found on clathrins, and often appears on proteins ...
 356-421 2.55e-30

Clathrin-H-link; This short domain is found on clathrins, and often appears on proteins directly downstream from the Clathrin-link domain pfam09268.


Pssm-ID: 463995  Cd Length: 66  Bit Score: 114.61  E-value: 2.55e-30
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1338802186  356 NLAGAEELFARKFNNLFAGGSYSEAAKVAANAPKGILRTPDTIRRFQSVPAQPGQTSPLLQYFGIL 421
Cdd:pfam13838    1 GLPGADDLYFQQFNQLLNQGDYAEAAKVAANSPRGALRTPETIQRFKQLPAQPGQLSPILQYFGTL 66
CLH smart00299
Clathrin heavy chain repeat homology;
541-674 3.17e-30

Clathrin heavy chain repeat homology;


Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 116.99  E-value: 3.17e-30
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1338802186   541 EPLADITQIVDVFMEYNLIQQCTSFLLDALKNNrPTEGPLQTRLLEMNLMHAPQVADAILGNqMFTHYDRAHVAQLCEKS 620
Cdd:smart00299    5 SDPIDVSEVVELFEKRNLLEELIPYLESALKLN-SENPALQTKLIELYAKYDPQKEIERLDN-KSNHYDIEKVGKLCEKA 82

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 1338802186   621 GLLQRALEHYTDLYDIKRAVVHT--HLLNPEWLVNYFGS-LSVEDSLECLKAMLSAN 674
Cdd:smart00299   83 KLYEEAVELYKKDGNFKDAIVTLieHLGNYEKAIEYFVKqNNPELWAEVLKALLDKP 139
Clathrin pfam00637
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are ...
 1128-1267 4.23e-30

Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are composed of multiple alpha helical repeats. They occur in the arm region of the Clathrin heavy chain.


Pssm-ID: 459884 [Multi-domain]  Cd Length: 142  Bit Score: 116.97  E-value: 4.23e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1338802186 1128 YIKADDPSAYMEVVQAANQSGNWEDLVKFLMMARKKARE--SYVETELIFALAKTNRLAELEEFINGPNNAHIQQVGDRC 1205
Cdd:pfam00637    1 LIESTDPIDVSRVVKLFEKAGLLEELISYLESALKEDSRenPALQTALIELYAKYDDPEELEEFLKKNNNYDLEKVAKLC 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1338802186 1206 YDEKMYDAAKLLYNNVSNFGRLASTLVHLGEFQAAVDGARKANSTRTWKEVCFACVDGKEFR 1267
Cdd:pfam00637   81 EKADLYEEAVILYKKIGNWKEAISLLKKLGDYKDAIEYAVKSSNPELWEELLEALLDNGRFE 142
Clathrin pfam00637
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are ...
 1427-1564 6.05e-30

Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are composed of multiple alpha helical repeats. They occur in the arm region of the Clathrin heavy chain.


Pssm-ID: 459884 [Multi-domain]  Cd Length: 142  Bit Score: 116.59  E-value: 6.05e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1338802186 1427 SPRLDHTRAVNFFTKMKQIPLVKPYLRSVQN---HNNKSVNEALNNLLIIEEDFQALRTSIDAYDNFDNISLAQSLEKHE 1503
Cdd:pfam00637    5 TDPIDVSRVVKLFEKAGLLEELISYLESALKedsRENPALQTALIELYAKYDDPEELEEFLKKNNNYDLEKVAKLCEKAD 84

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1338802186 1504 LIEFRRiaaYLFKGNNRWKQSIELCKKDQLYKDAMQYAAESKDIEVAEELLQWFLQEDKKE 1564
Cdd:pfam00637   85 LYEEAV---ILYKKIGNWKEAISLLKKLGDYKDAIEYAVKSSNPELWEELLEALLDNGRFE 142
CLH smart00299
Clathrin heavy chain repeat homology;
833-968 1.16e-28

Clathrin heavy chain repeat homology;


Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 112.75  E-value: 1.16e-28
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1338802186   833 IMVVRGQFSTDELVAEVEKRNRLKLLLPWLEGRIHEGCEEPATHNALAKIYIDSNNNP--ERFLKENPYYDSRVVGKYCE 910
Cdd:smart00299    1 LLEVSDPIDVSEVVELFEKRNLLEELIPYLESALKLNSENPALQTKLIELYAKYDPQKeiERLDNKSNHYDIEKVGKLCE 80

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1338802186   911 KRDPH-LACVAYERGQCDQELIHVCNENS-LFKSLSRYLVRRKDHDLWGSVLLESNPYRR 968
Cdd:smart00299   81 KAKLYeEAVELYKKDGNFKDAIVTLIEHLgNYEKAIEYFVKQNNPELWAEVLKALLDKPR 140
Clathrin pfam00637
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are ...
 1274-1416 2.63e-27

Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are composed of multiple alpha helical repeats. They occur in the arm region of the Clathrin heavy chain.


Pssm-ID: 459884 [Multi-domain]  Cd Length: 142  Bit Score: 108.88  E-value: 2.63e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1338802186 1274 LHIVVHADELEELINYYQDRGYFEELITMLEAALGL-ERAHMGMFTELAILYSKF-KPQKMREHLELFWSrVNIPKVLRA 1351
Cdd:pfam00637    1 LIESTDPIDVSRVVKLFEKAGLLEELISYLESALKEdSRENPALQTALIELYAKYdDPEELEEFLKKNNN-YDLEKVAKL 79

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1338802186 1352 AEQAHLWAELVFLYDKYEEYDNAIitMMNHPTDAWKEGQfkDIVTKVANVELYYRAIQFYLDFKP 1416
Cdd:pfam00637   80 CEKADLYEEAVILYKKIGNWKEAI--SLLKKLGDYKDAI--EYAVKSSNPELWEELLEALLDNGR 140
Clathrin pfam00637
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are ...
 688-826 1.94e-25

Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are composed of multiple alpha helical repeats. They occur in the arm region of the Clathrin heavy chain.


Pssm-ID: 459884 [Multi-domain]  Cd Length: 142  Bit Score: 103.49  E-value: 1.94e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1338802186  688 KYHEQLGTQALTDLFESFKSFEGLFYFLGSIVNFS--QDPEVHFKYIQAACKTGQIKEVERICRESNCYDAERVKNFLKE 765
Cdd:pfam00637    3 ESTDPIDVSRVVKLFEKAGLLEELISYLESALKEDsrENPALQTALIELYAKYDDPEELEEFLKKNNNYDLEKVAKLCEK 82

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1338802186  766 AKLTDQLPLIIVCdrFDFVHDLV-LYLYRNSLQKYIEIYVQKVNPSRLPVVIGGLLDVDCSE 826
Cdd:pfam00637   83 ADLYEEAVILYKK--IGNWKEAIsLLKKLGDYKDAIEYAVKSSNPELWEELLEALLDNGRFE 142
Clathrin pfam00637
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are ...
 843-970 3.54e-25

Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are composed of multiple alpha helical repeats. They occur in the arm region of the Clathrin heavy chain.


Pssm-ID: 459884 [Multi-domain]  Cd Length: 142  Bit Score: 102.72  E-value: 3.54e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1338802186  843 DELVAEVEKRNRLKLLLPWLEGRIHEG-CEEPATHNALAKIYIDSN--NNPERFLKENPYYDSRVVGKYCEKRDPH-LAC 918
Cdd:pfam00637   11 SRVVKLFEKAGLLEELISYLESALKEDsRENPALQTALIELYAKYDdpEELEEFLKKNNNYDLEKVAKLCEKADLYeEAV 90

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1338802186  919 VAYERGQCDQELIHVCNENSLFKSLSRYLVRRKDHDLWGSVLLESNPYRRPL 970
Cdd:pfam00637   91 ILYKKIGNWKEAISLLKKLGDYKDAIEYAVKSSNPELWEELLEALLDNGRFE 142
Clathrin pfam00637
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are ...
 541-678 2.23e-24

Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are composed of multiple alpha helical repeats. They occur in the arm region of the Clathrin heavy chain.


Pssm-ID: 459884 [Multi-domain]  Cd Length: 142  Bit Score: 100.41  E-value: 2.23e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1338802186  541 EPLADITQIVDVFMEYNLIQQCTSFLLDALKNNRPTEGPLQTRLLEMNLMHAP-QVADAILgnQMFTHYDRAHVAQLCEK 619
Cdd:pfam00637    5 TDPIDVSRVVKLFEKAGLLEELISYLESALKEDSRENPALQTALIELYAKYDDpEELEEFL--KKNNNYDLEKVAKLCEK 82

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1338802186  620 SGLLQRALEHYTDLYDIKRAV-VHTHLLNPEWLVNYFGSLSVEDSLECLKAMLSANIRQN 678
Cdd:pfam00637   83 ADLYEEAVILYKKIGNWKEAIsLLKKLGDYKDAIEYAVKSSNPELWEELLEALLDNGRFE 142
CLH smart00299
Clathrin heavy chain repeat homology;
1427-1578 3.10e-23

Clathrin heavy chain repeat homology;


Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 96.96  E-value: 3.10e-23
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1338802186  1427 SPRLDHTRAVNFFTKMKQIPLVKPYLRSVQNHNnkSVNEALNNLLIIEEDFQALRTSIDAYDNFdnislaqslekHELIE 1506
Cdd:smart00299    5 SDPIDVSEVVELFEKRNLLEELIPYLESALKLN--SENPALQTKLIELYAKYDPQKEIERLDNK-----------SNHYD 71

                            90       100       110       120       130       140       150
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1338802186  1507 FRRIAAYLFKGNNrWKQSIELCKKDQLYKDAMQYAaeSKDIEVAEELLQWFLQEDKKECFAACLFTCYDLLR 1578
Cdd:smart00299   72 IEKVGKLCEKAKL-YEEAVELYKKDGNFKDAIVTL--IEHLGNYEKAIEYFVKQNNPELWAEVLKALLDKPR 140
Clathrin-link pfam09268
Clathrin, heavy-chain linker; Members of this family adopt a structure consisting of ...
 331-354 2.96e-09

Clathrin, heavy-chain linker; Members of this family adopt a structure consisting of alpha-alpha superhelix. They are predominantly found in clathrin, where they act as a heavy-chain linker domain.


Pssm-ID: 462732  Cd Length: 24  Bit Score: 53.60  E-value: 2.96e-09
                           10        20
                   ....*....|....*....|....
gi 1338802186  331 EENIIPYITNVLQNSDLALRMAVR 354
Cdd:pfam09268    1 EDNIIPYILNTLQNPDLALRLASR 24
Clathrin_propel pfam01394
Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that ...
 198-234 3.33e-07

Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that surrounds coated vesicles. The soluble assembly unit, a triskelion, contains three heavy chains and three light chains in an extended three-legged structure. Each leg contains one heavy and one light chain. The N-terminus of the heavy chain is known as the globular domain, and is composed of seven repeats which form a beta propeller.


Pssm-ID: 460192  Cd Length: 37  Bit Score: 48.18  E-value: 3.33e-07
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1338802186  198 AASFAQFKMEGNAEESTLFCFAVRGQAGGKLHIIEVG 234
Cdd:pfam01394    1 NAISAIIIFPTATMESWLFIIAINGTKKGQVQIVDVE 37
Clathrin_propel pfam01394
Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that ...
 19-56 5.46e-05

Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that surrounds coated vesicles. The soluble assembly unit, a triskelion, contains three heavy chains and three light chains in an extended three-legged structure. Each leg contains one heavy and one light chain. The N-terminus of the heavy chain is known as the globular domain, and is composed of seven repeats which form a beta propeller.


Pssm-ID: 460192  Cd Length: 37  Bit Score: 41.63  E-value: 5.46e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1338802186   19 GINPANIGFSTLTMESDKFICIREKVGeQAQVVIIDMN 56
Cdd:pfam01394    1 NAISAIIIFPTATMESWLFIIAINGTK-KGQVQIVDVE 37
Clathrin_propel pfam01394
Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that ...
 256-288 9.47e-05

Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that surrounds coated vesicles. The soluble assembly unit, a triskelion, contains three heavy chains and three light chains in an extended three-legged structure. Each leg contains one heavy and one light chain. The N-terminus of the heavy chain is known as the globular domain, and is composed of seven repeats which form a beta propeller.


Pssm-ID: 460192  Cd Length: 37  Bit Score: 41.25  E-value: 9.47e-05
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1338802186  256 AQNDFPVAMQISSKQDVVFLITKYGYIHLYDLE 288
Cdd:pfam01394    5 AIIIFPTATMESWLFIIAINGTKKGQVQIVDVE 37
Coatomer_WDAD pfam04053
Coatomer WD associated region; This region is composed of WD40 repeats.
 1074-1133 1.16e-04

Coatomer WD associated region; This region is composed of WD40 repeats.


Pssm-ID: 427679  Cd Length: 439  Bit Score: 46.46  E-value: 1.16e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1338802186 1074 KFDVntsAVQvliehIGNLDRAYEFAERCNEPAVWSQLGKAQLLKGLVKEAIDSYIKADD 1133
Cdd:pfam04053  320 RFDL---ALE-----LGNLDVALEIAKELDDPAKWKRLGDAALSQGNIKLAEEAYQKAKD 371
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 1056-1247 1.86e-04

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 45.11  E-value: 1.86e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1338802186 1056 ANIAISNELFEEAFAIFRK-FDVNTSAVQVLI------EHIGNLDRAYEFAERC-----NEPAVWSQLGKAQLLKGLVKE 1123
Cdd:COG2956     15 GLNYLLNGQPDKAIDLLEEaLELDPETVEAHLalgnlyRRRGEYDRAIRIHQKLlerdpDRAEALLELAQDYLKAGLLDR 94

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1338802186 1124 AIDSYIKA-----DDPSAYMEVVQAANQSGNWEDLVKFL-MMARKKARESYVETELIFALAKTNRLAE----LEEFING- 1192
Cdd:COG2956     95 AEELLEKLleldpDDAEALRLLAEIYEQEGDWEKAIEVLeRLLKLGPENAHAYCELAELYLEQGDYDEaieaLEKALKLd 174

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1338802186 1193 PNNAHIQ-QVGDRCYDEKMYDAAKLLY--------NNVSNFGRLASTLVHLGEFQAAVDGARKA 1247
Cdd:COG2956    175 PDCARALlLLAELYLEQGDYEEAIAALeraleqdpDYLPALPRLAELYEKLGDPEEALELLRKA 238
Clathrin_propel pfam01394
Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that ...
 296-330 2.16e-04

Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that surrounds coated vesicles. The soluble assembly unit, a triskelion, contains three heavy chains and three light chains in an extended three-legged structure. Each leg contains one heavy and one light chain. The N-terminus of the heavy chain is known as the globular domain, and is composed of seven repeats which form a beta propeller.


Pssm-ID: 460192  Cd Length: 37  Bit Score: 40.09  E-value: 2.16e-04
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1338802186  296 NRISGETIFVTAPHEATAGIIGVN--RKGQVLSVCVE 330
Cdd:pfam01394    1 NAISAIIIFPTATMESWLFIIAINgtKKGQVQIVDVE 37
Clathrin_propel pfam01394
Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that ...
 148-187 3.30e-04

Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that surrounds coated vesicles. The soluble assembly unit, a triskelion, contains three heavy chains and three light chains in an extended three-legged structure. Each leg contains one heavy and one light chain. The N-terminus of the heavy chain is known as the globular domain, and is composed of seven repeats which form a beta propeller.


Pssm-ID: 460192  Cd Length: 37  Bit Score: 39.71  E-value: 3.30e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1338802186  148 LAGCQIINYRTDAKQKWLLLIGISaqqNRVVGAMQLYSVD 187
Cdd:pfam01394    1 NAISAIIIFPTATMESWLFIIAIN---GTKKGQVQIVDVE 37
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 1108-1375 3.65e-04

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 44.33  E-value: 3.65e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1338802186 1108 WSQLGKAQLLKGLVKEAIDSYIKA-----DDPSAYMEVVQAANQSGNWEDLVKFL--MMARKKARESYVEtELIFALAKT 1180
Cdd:COG2956     11 WYFKGLNYLLNGQPDKAIDLLEEAleldpETVEAHLALGNLYRRRGEYDRAIRIHqkLLERDPDRAEALL-ELAQDYLKA 89

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1338802186 1181 NRLAELEEFIN-----GPNNAH-IQQVGDRCYDEKMYDAAKLLYNNVSNFG--------RLASTLVHLGEFQAAVDGARK 1246
Cdd:COG2956     90 GLLDRAEELLEkllelDPDDAEaLRLLAEIYEQEGDWEKAIEVLERLLKLGpenahaycELAELYLEQGDYDEAIEALEK 169

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1338802186 1247 ANSTRtwkevcfacvdgKEFRLAQMcglhivvhadeleELINYYQDRGYFEELITMLEAALGLERAHMGMFTELAILYSK 1326
Cdd:COG2956    170 ALKLD------------PDCARALL-------------LLAELYLEQGDYEEAIAALERALEQDPDYLPALPRLAELYEK 224

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|
gi 1338802186 1327 F-KPQKMREHLElfwsrvnipKVLRAAEQAHLWAELVFLYDKYEEYDNAI 1375
Cdd:COG2956    225 LgDPEEALELLR---------KALELDPSDDLLLALADLLERKEGLEAAL 265
Coatomer_WDAD_beta-like cd22947
Coatomer WD Associated Region from Coatomer Subunit Beta and Beta'; Coatomer subunit beta', ...
 1061-1185 5.17e-04

Coatomer WD Associated Region from Coatomer Subunit Beta and Beta'; Coatomer subunit beta', also called beta'-coat protein; beta'-COP; p102, is a component of the coatomer, which is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complexes are hetero-oligomers composed of at least an alpha, beta, beta', gamma, delta, epsilon and zeta subunit. It is a heptameric complex that can polymerize into a cage to deform the membrane into a bud. This model corresponds to the WD-associated (WDAD) region found in coatomer subunits beta and beta' and is composed of a beta-propeller and an alpha-solenoid. The WD40 domain is found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly. It typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40. Between the GH and WD lies a conserved core. It forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet. Each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade. The last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure. The residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands allowing them to bind either stably or reversibly.


Pssm-ID: 438572  Cd Length: 475  Bit Score: 44.77  E-value: 5.17e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1338802186 1061 SNELFEEAFAIFR----KFDVntsAVQvliehIGNLDRAYEFAERCNEPAVWSQLGKAQLLKGLVKEAIDSYIKADDPSA 1136
Cdd:cd22947    324 SQGLKELALEVSTdpdhKFEL---ALQ-----LGDLDLALEIARESESESKWKQLGDLALSKGDFDLAEECLKKAGDLSG 395

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1338802186 1137 YMEVVQAanqSGNWEDLVKFLMMARKK-----ARESYVET----ELIFALAKTNRLAE 1185
Cdd:cd22947    396 LLLLYSS---TGDKEGLEELAELAEAAgknniAFLAYFLLgdldKCVDLLIKTGRLPE 450
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 1054-1186 2.40e-03

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 42.67  E-value: 2.40e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1338802186 1054 DIANIAISNELFEEAFAIFRKF-DVNTSAVQVLI------EHIGNLDRAYEFAERC-----NEPAVWSQLGKAQLLKGLV 1121
Cdd:COG3914    117 NLGNLLLALGRLEEALAALRRAlALNPDFAEAYLnlgealRRLGRLEEAIAALRRAleldpDNAEALNNLGNALQDLGRL 196

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1338802186 1122 KEAIDSYIKA-----DDPSAYMEVVQAANQSGNWEDLVKFLMMARKKARESYVETELIFALAKTNRLAEL 1186
Cdd:COG3914    197 EEAIAAYRRAleldpDNADAHSNLLFALRQACDWEVYDRFEELLAALARGPSELSPFALLYLPDDDPAEL 266
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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