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Conserved domains on  [gi|1370499282|ref|XP_024301892|]
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transmembrane and coiled-coil domain-containing protein 6 isoform X6 [Homo sapiens]

Protein Classification

armadillo/beta-catenin-like repeat-containing protein( domain architecture ID 1000979)

armadillo/beta-catenin-like repeat-containing protein similar to Saccharomyces cerevisiae vacuolar protein 8 that functions in both vacuole inheritance and protein targeting from the cytoplasm to vacuole

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SRP1 super family cl34886
Karyopherin (importin) alpha [Intracellular trafficking and secretion];
4-290 2.34e-08

Karyopherin (importin) alpha [Intracellular trafficking and secretion];


The actual alignment was detected with superfamily member COG5064:

Pssm-ID: 227396 [Multi-domain]  Cd Length: 526  Bit Score: 55.67  E-value: 2.34e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370499282   4 LVGLLTSNQA-LLQLEAARCLHELSH--SEQSTVAEAClPATSYLLTYLSSHSSDFIELCLYTLGNLIVESEAVRRQLLP 80
Cdd:COG5064   119 FVEFMDEIQRdMLQFEAAWALTNIASgtTQQTKVVVDA-GAVPLFIQLLSSTEDDVREQAVWALGNIAGDSEGCRDYVLQ 197

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370499282  81 QGIVPALAACIQS--PHVAVLEALGYALSQLLQAEEAPekiipPASASSSILASTLPQHMLQMlqpgpklNPGVAVEFAW 158
Cdd:COG5064   198 CGALEPLLGLLLSsaIHISMLRNATWTLSNLCRGKNPP-----PDWSNISQALPILAKLIYSR-------DPEVLVDACW 265

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370499282 159 CLHYIicSQVSNpllighgalstlglllldlaGAVQKTEDAG-----LELLA-------CPVLRCLSNLLTEAAVETvgg 226
Cdd:COG5064   266 AISYL--SDGPN--------------------EKIQAVLDVGipgrlVELLShesakiqTPALRSVGNIVTGSDDQT--- 320

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1370499282 227 QMQLRdervVAALFILLQFFFQKQPSLLPEGLWLLNNLTANSPSFCTSLLSLDLIEPLLQLLPV 290
Cdd:COG5064   321 QVIIN----CGALKAFRSLLSSPKENIRKEACWTISNITAGNTEQIQAVIDANLIPPLIHLLSS 380
 
Name Accession Description Interval E-value
SRP1 COG5064
Karyopherin (importin) alpha [Intracellular trafficking and secretion];
4-290 2.34e-08

Karyopherin (importin) alpha [Intracellular trafficking and secretion];


Pssm-ID: 227396 [Multi-domain]  Cd Length: 526  Bit Score: 55.67  E-value: 2.34e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370499282   4 LVGLLTSNQA-LLQLEAARCLHELSH--SEQSTVAEAClPATSYLLTYLSSHSSDFIELCLYTLGNLIVESEAVRRQLLP 80
Cdd:COG5064   119 FVEFMDEIQRdMLQFEAAWALTNIASgtTQQTKVVVDA-GAVPLFIQLLSSTEDDVREQAVWALGNIAGDSEGCRDYVLQ 197

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370499282  81 QGIVPALAACIQS--PHVAVLEALGYALSQLLQAEEAPekiipPASASSSILASTLPQHMLQMlqpgpklNPGVAVEFAW 158
Cdd:COG5064   198 CGALEPLLGLLLSsaIHISMLRNATWTLSNLCRGKNPP-----PDWSNISQALPILAKLIYSR-------DPEVLVDACW 265

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370499282 159 CLHYIicSQVSNpllighgalstlglllldlaGAVQKTEDAG-----LELLA-------CPVLRCLSNLLTEAAVETvgg 226
Cdd:COG5064   266 AISYL--SDGPN--------------------EKIQAVLDVGipgrlVELLShesakiqTPALRSVGNIVTGSDDQT--- 320

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1370499282 227 QMQLRdervVAALFILLQFFFQKQPSLLPEGLWLLNNLTANSPSFCTSLLSLDLIEPLLQLLPV 290
Cdd:COG5064   321 QVIIN----CGALKAFRSLLSSPKENIRKEACWTISNITAGNTEQIQAVIDANLIPPLIHLLSS 380
 
Name Accession Description Interval E-value
SRP1 COG5064
Karyopherin (importin) alpha [Intracellular trafficking and secretion];
4-290 2.34e-08

Karyopherin (importin) alpha [Intracellular trafficking and secretion];


Pssm-ID: 227396 [Multi-domain]  Cd Length: 526  Bit Score: 55.67  E-value: 2.34e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370499282   4 LVGLLTSNQA-LLQLEAARCLHELSH--SEQSTVAEAClPATSYLLTYLSSHSSDFIELCLYTLGNLIVESEAVRRQLLP 80
Cdd:COG5064   119 FVEFMDEIQRdMLQFEAAWALTNIASgtTQQTKVVVDA-GAVPLFIQLLSSTEDDVREQAVWALGNIAGDSEGCRDYVLQ 197

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370499282  81 QGIVPALAACIQS--PHVAVLEALGYALSQLLQAEEAPekiipPASASSSILASTLPQHMLQMlqpgpklNPGVAVEFAW 158
Cdd:COG5064   198 CGALEPLLGLLLSsaIHISMLRNATWTLSNLCRGKNPP-----PDWSNISQALPILAKLIYSR-------DPEVLVDACW 265

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370499282 159 CLHYIicSQVSNpllighgalstlglllldlaGAVQKTEDAG-----LELLA-------CPVLRCLSNLLTEAAVETvgg 226
Cdd:COG5064   266 AISYL--SDGPN--------------------EKIQAVLDVGipgrlVELLShesakiqTPALRSVGNIVTGSDDQT--- 320

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1370499282 227 QMQLRdervVAALFILLQFFFQKQPSLLPEGLWLLNNLTANSPSFCTSLLSLDLIEPLLQLLPV 290
Cdd:COG5064   321 QVIIN----CGALKAFRSLLSSPKENIRKEACWTISNITAGNTEQIQAVIDANLIPPLIHLLSS 380
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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