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Conserved domains on  [gi|2217281666|ref|XP_024304166|]
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lysosomal membrane ascorbate-dependent ferrireductase CYB561A3 isoform X2 [Homo sapiens]

Protein Classification

cytochrome b family protein( domain architecture ID 581032)

cytochrome b family protein such as formate dehydrogenase subunit gamma or cytochrome b, a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.

Gene Ontology:  GO:0046872|GO:0016491

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cytochrome_b_N super family cl23723
Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit ...
 36-148 1.12e-66

Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria, cytochrome b6 is analogous to eukaryote cytochrome b, containing two chains: helices A-D are encoded by the petB gene and helices E-H are encoded by the petD gene in these organisms. Cytochrome b/b6 contains two bound hemes and two ubiquinol/ubiquinone binding sites. The C-terminal portion of cytochrome b is described in a separate CD.


The actual alignment was detected with superfamily member cd08762:

Pssm-ID: 474033  Cd Length: 179  Bit Score: 202.79  E-value: 1.12e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217281666  36 MCILFTIYWMQYWRGGFAWNGSIYMFNWHPVLMVAGMVVFYGGASLVYRLPQSWVGPKLPWKLLHAALHLMAFVLTVVGL 115
Cdd:cd08762    10 ACVVLVVHWNQMWRGGFAWDGSSKNFNWHPVLMVTGMVVLYGNAALVYRIPLTWGGPKLPWKLLHAGLLLLAFILTVIGL 89

                          90       100       110
                  ....*....|....*....|....*....|...
gi 2217281666 116 VAVFTFHNHGRTANLYSLHSWLGITTVFLFACQ 148
Cdd:cd08762    90 CAVFNFHNVHHTANLYSLHSWVGICTVALFTCQ 122
 
Name Accession Description Interval E-value
Cyt_b561_CYBASC3 cd08762
Vertebrate cytochrome b(561), CYBASC3 gene product; Cytochrome b ascorbate-dependent 3, as ...
 36-148 1.12e-66

Vertebrate cytochrome b(561), CYBASC3 gene product; Cytochrome b ascorbate-dependent 3, as found in vertebrates, which might act as a ferric-chelate reductase, catalyzing the reduction of Fe(3+) to Fe(2+), such as associated with the transport of iron from the endosome to the cytoplasm. It is assumed that this protein uses ascorbate as the electron donor. Belongs to the cytochrome b(561) family, which are secretory vesicle-specific electron transport proteins. Cytochromes b(561) are integral membrane proteins that bind two heme groups non-covalently, and may have six alpha-helical trans-membrane segments.


Pssm-ID: 176492  Cd Length: 179  Bit Score: 202.79  E-value: 1.12e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217281666  36 MCILFTIYWMQYWRGGFAWNGSIYMFNWHPVLMVAGMVVFYGGASLVYRLPQSWVGPKLPWKLLHAALHLMAFVLTVVGL 115
Cdd:cd08762    10 ACVVLVVHWNQMWRGGFAWDGSSKNFNWHPVLMVTGMVVLYGNAALVYRIPLTWGGPKLPWKLLHAGLLLLAFILTVIGL 89

                          90       100       110
                  ....*....|....*....|....*....|...
gi 2217281666 116 VAVFTFHNHGRTANLYSLHSWLGITTVFLFACQ 148
Cdd:cd08762    90 CAVFNFHNVHHTANLYSLHSWVGICTVALFTCQ 122
Cytochrom_B561 pfam03188
Eukaryotic cytochrome b561; Cytochrome b561 is a secretory vesicle-specific electron transport ...
 63-151 8.04e-31

Eukaryotic cytochrome b561; Cytochrome b561 is a secretory vesicle-specific electron transport protein. It is an integral membrane protein, that binds two heme groups non-covalently. This is a eukaryotic family. Members of the 'prokaryotic cytochrome b561' family can be found in Pfam: PF01292.


Pssm-ID: 427188  Cd Length: 137  Bit Score: 110.00  E-value: 8.04e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217281666  63 WHPVLMVAGMVVFYGGASLVYRLPQSWVGPKLPWKLLHAALHLMAFVLTVVGLVAVFTFHNHGRTANLYSLHSWLGITTV 142
Cdd:pfam03188   1 WHPVLMVIGFIFLMGEAILVYRVNSTRRLSKKTKKLLHWILQALALILAVIGLVAVFKFHNLSGIPHFYSLHSWLGLLTV 80


                  ....*....
gi 2217281666 143 FLFACQACA 151
Cdd:pfam03188  81 ILYALQWVG 89
B561 smart00665
Cytochrome b-561 / ferric reductase transmembrane domain; Cytochrome b-561 recycles ascorbate ...
 63-148 1.12e-22

Cytochrome b-561 / ferric reductase transmembrane domain; Cytochrome b-561 recycles ascorbate for the generation of norepinephrine by dopamine-beta-hydroxylase in the chromaffin vesicles of the adrenal gland. It is a transmembrane heme protein with the two heme groups being bound to conserved histidine residues. A cytochrome b-561 homologue, termed Dcytb, is an iron-regulated ferric reductase in the duodenal mucosa. Other homologues of these are also likely to be ferric reductases. SDR2 is proposed to be important in regulating the metabolism of iron in the onset of neurodegenerative disorders.


Pssm-ID: 214769  Cd Length: 129  Bit Score: 88.83  E-value: 1.12e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217281666   63 WHPVLMVAGMVVFYGGASLVYRLPQSWVGPKLpWKLLHAALHLMAFVLTVVGLVAVFTFHNHGRTANLYSLHSWLGITTV 142
Cdd:smart00665   1 LHPVLMILGFGFLMGEAILVARPLTRFLSKPT-WFLLHVVLQILALVLGVIGLLAIFISHNESGIANFYSLHSWLGLAAF 79


                   ....*.
gi 2217281666  143 FLFACQ 148
Cdd:smart00665  80 VLAGLQ 85
PLN02680 PLN02680
carbon-monoxide oxygenase
 40-148 1.12e-21

carbon-monoxide oxygenase


Pssm-ID: 215365  Cd Length: 232  Bit Score: 88.70  E-value: 1.12e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217281666  40 FTIYWMQYWRGGFAW--NGSIYMFNWHPVLMVAGMVVFYGGASLVYRLPQswvGPKLPWKLLHAALHLMAFVLTVVGLVA 117
Cdd:PLN02680   24 LVLTWTVHYRGGLALssDNKDLIFNVHPVLMVIGLVLLNGEAMLAYKTVP---GTKNLKKLVHLTLQFLAFCLSLIGVWA 100

                          90       100       110
                  ....*....|....*....|....*....|.
gi 2217281666 118 VFTFHNHGRTANLYSLHSWLGITTVFLFACQ 148
Cdd:PLN02680  101 ALKFHNEKGIDNFYSLHSWLGLACLFLFSLQ 131
 
Name Accession Description Interval E-value
Cyt_b561_CYBASC3 cd08762
Vertebrate cytochrome b(561), CYBASC3 gene product; Cytochrome b ascorbate-dependent 3, as ...
 36-148 1.12e-66

Vertebrate cytochrome b(561), CYBASC3 gene product; Cytochrome b ascorbate-dependent 3, as found in vertebrates, which might act as a ferric-chelate reductase, catalyzing the reduction of Fe(3+) to Fe(2+), such as associated with the transport of iron from the endosome to the cytoplasm. It is assumed that this protein uses ascorbate as the electron donor. Belongs to the cytochrome b(561) family, which are secretory vesicle-specific electron transport proteins. Cytochromes b(561) are integral membrane proteins that bind two heme groups non-covalently, and may have six alpha-helical trans-membrane segments.


Pssm-ID: 176492  Cd Length: 179  Bit Score: 202.79  E-value: 1.12e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217281666  36 MCILFTIYWMQYWRGGFAWNGSIYMFNWHPVLMVAGMVVFYGGASLVYRLPQSWVGPKLPWKLLHAALHLMAFVLTVVGL 115
Cdd:cd08762    10 ACVVLVVHWNQMWRGGFAWDGSSKNFNWHPVLMVTGMVVLYGNAALVYRIPLTWGGPKLPWKLLHAGLLLLAFILTVIGL 89

                          90       100       110
                  ....*....|....*....|....*....|...
gi 2217281666 116 VAVFTFHNHGRTANLYSLHSWLGITTVFLFACQ 148
Cdd:cd08762    90 CAVFNFHNVHHTANLYSLHSWVGICTVALFTCQ 122
Cyt_b561_CG1275_like cd08764
Non-vertebrate eumetazoan cytochrome b(561); Cytochrome b(561), as found in non-vertebrate ...
 38-148 2.42e-40

Non-vertebrate eumetazoan cytochrome b(561); Cytochrome b(561), as found in non-vertebrate eumetazoans, similar to the Drosophila melanogaster CG1275 gene product. This protein might act as a ferric-chelate reductase, catalyzing the reduction of Fe(3+) to Fe(2+), such as associated with the transport of iron from the endosome to the cytoplasm. It is assumed that this protein uses ascorbate as the electron donor. Belongs to the cytochrome b(561) family, which are secretory vesicle-specific electron transport proteins. Cytochromes b(561) are integral membrane proteins that bind two heme groups non-covalently, and may have six alpha-helical trans-membrane segments.


Pssm-ID: 176494  Cd Length: 214  Bit Score: 136.69  E-value: 2.42e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217281666  38 ILFTIYWMQYWRGGFAWNGSIYMFNWHPVLMVAGMVVFYGGASLVYRLPQSWVgpKLPWKLLHAALHLMAFVLTVVGLVA 117
Cdd:cd08764     1 VVLVGIWLGKFRGGFSWTGPGLQFNWHPLLMVLGLIFLYGNSILVYRVFRNTR--KKRLKLLHAVLHLLAFILAVIGLKA 78

                          90       100       110
                  ....*....|....*....|....*....|...
gi 2217281666 118 VFTFHNHGR--TANLYSLHSWLGITTVFLFACQ 148
Cdd:cd08764    79 VFDSHNLAKppIPNMYSLHSWLGLTAVILFSLQ 111
Cytochrom_B561 pfam03188
Eukaryotic cytochrome b561; Cytochrome b561 is a secretory vesicle-specific electron transport ...
 63-151 8.04e-31

Eukaryotic cytochrome b561; Cytochrome b561 is a secretory vesicle-specific electron transport protein. It is an integral membrane protein, that binds two heme groups non-covalently. This is a eukaryotic family. Members of the 'prokaryotic cytochrome b561' family can be found in Pfam: PF01292.


Pssm-ID: 427188  Cd Length: 137  Bit Score: 110.00  E-value: 8.04e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217281666  63 WHPVLMVAGMVVFYGGASLVYRLPQSWVGPKLPWKLLHAALHLMAFVLTVVGLVAVFTFHNHGRTANLYSLHSWLGITTV 142
Cdd:pfam03188   1 WHPVLMVIGFIFLMGEAILVYRVNSTRRLSKKTKKLLHWILQALALILAVIGLVAVFKFHNLSGIPHFYSLHSWLGLLTV 80


                  ....*....
gi 2217281666 143 FLFACQACA 151
Cdd:pfam03188  81 ILYALQWVG 89
Cyt_b561_CYBRD1 cd08765
Vertebrate cytochrome b(561), CYBRD1 gene product; Duodenal cytochrome b or ferric-chelate ...
 51-148 3.10e-30

Vertebrate cytochrome b(561), CYBRD1 gene product; Duodenal cytochrome b or ferric-chelate reductase 3, a cytochrome b(561), as found in vertebrates, which might act as a ferric-chelate reductase, catalyzing the reduction of Fe(3+) to Fe(2+), such as associated with the transport of iron from the endosome to the cytoplasm. It is assumed that this protein uses ascorbate as the electron donor. This protein is expressed at the brush border of duodenal enterocytes and may play a role in the uptake of dietary Fe(3+), facilitating its transport into the mucosal cells. It may also be involved in the recycling of extracellular ascorbate in erythrocyte membranes, and act as a ferrireductase in epithelial cells of the respiratory system. Belongs to the cytochrome b(561) family, which are secretory vesicle-specific electron transport proteins. Cytochromes b(561) are integral membrane proteins that bind two heme groups non-covalently, and may have six alpha-helical trans-membrane segments.


Pssm-ID: 176495  Cd Length: 153  Bit Score: 108.83  E-value: 3.10e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217281666  51 GFAWNGSIYMFNWHPVLMVAGMVVFYGGASLVYRLPQSWVGPKLPWKLLHAALHLMAFVLTVVGLVAVFTFHNHGRTANL 130
Cdd:cd08765     2 GLGWDGGAAEFNWHPVLMVIGFIFIQGIAIIVYRLPWTWKCSKLLMKLIHAGLHILAFILAIISVVAVFVFHNAKNIPNM 81

                          90
                  ....*....|....*...
gi 2217281666 131 YSLHSWLGITTVFLFACQ 148
Cdd:cd08765    82 YSLHSWVGLAAVILYPLQ 99
Cyt_b561 cd08554
Eukaryotic cytochrome b(561); Cytochrome b(561) is a family of endosomal or secretory ...
 60-148 6.43e-28

Eukaryotic cytochrome b(561); Cytochrome b(561) is a family of endosomal or secretory vesicle-specific electron transport proteins. They are integral membrane proteins that bind two heme groups non-covalently, and may have six alpha-helical trans-membrane segments. This is an exclusively eukaryotic family. Members of the prokaryotic cytochrome b561 family are not deemed homologous.


Pssm-ID: 176489  Cd Length: 131  Bit Score: 102.36  E-value: 6.43e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217281666  60 MFNWHPVLMVAGMVVFYGGASLVYRLPqsWVGPKLPWKLLHAALHLMAFVLTVVGLVAVFTFHNHGRTANLYSLHSWLGI 139
Cdd:cd08554     1 EFNWHPLLMVIGFVFLMGEALLVYRVF--RLLTKRALKLLHAILHLLAFVLGLVGLLAVFLFHNAGGIANLYSLHSWLGL 78


                  ....*....
gi 2217281666 140 TTVFLFACQ 148
Cdd:cd08554    79 ATVLLFLLQ 87
B561 smart00665
Cytochrome b-561 / ferric reductase transmembrane domain; Cytochrome b-561 recycles ascorbate ...
 63-148 1.12e-22

Cytochrome b-561 / ferric reductase transmembrane domain; Cytochrome b-561 recycles ascorbate for the generation of norepinephrine by dopamine-beta-hydroxylase in the chromaffin vesicles of the adrenal gland. It is a transmembrane heme protein with the two heme groups being bound to conserved histidine residues. A cytochrome b-561 homologue, termed Dcytb, is an iron-regulated ferric reductase in the duodenal mucosa. Other homologues of these are also likely to be ferric reductases. SDR2 is proposed to be important in regulating the metabolism of iron in the onset of neurodegenerative disorders.


Pssm-ID: 214769  Cd Length: 129  Bit Score: 88.83  E-value: 1.12e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217281666   63 WHPVLMVAGMVVFYGGASLVYRLPQSWVGPKLpWKLLHAALHLMAFVLTVVGLVAVFTFHNHGRTANLYSLHSWLGITTV 142
Cdd:smart00665   1 LHPVLMILGFGFLMGEAILVARPLTRFLSKPT-WFLLHVVLQILALVLGVIGLLAIFISHNESGIANFYSLHSWLGLAAF 79


                   ....*.
gi 2217281666  143 FLFACQ 148
Cdd:smart00665  80 VLAGLQ 85
Cyt_b561_ACYB-1_like cd08766
Plant cytochrome b(561), including the carbon monoxide oxygenase ACYB-1; Cytochrome b(561), as ...
 61-148 1.36e-22

Plant cytochrome b(561), including the carbon monoxide oxygenase ACYB-1; Cytochrome b(561), as found in plants, similar to the Arabidopsis thaliana ACYB-1 gene product, a cytochrome b561 isoform localized to the tonoplast. This protein might act as a ferric-chelate reductase, catalyzing the reduction of Fe(3+) to Fe(2+), and might be capable of trans-membrane electron transport from intracellular ascorbate to extracellular ferric chelates. It is assumed that this protein uses ascorbate as the electron donor. Belongs to the cytochrome b(561) family, which are secretory vesicle-specific electron transport proteins. Cytochromes b(561) are integral membrane proteins that bind two heme groups non-covalently, and may have six alpha-helical trans-membrane segments.


Pssm-ID: 176496  Cd Length: 144  Bit Score: 88.90  E-value: 1.36e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217281666  61 FNWHPVLMVAGMVVFYGGASLVYRlpqSWVGPKLPWKLLHAALHLMAFVLTVVGLVAVFTFHNHGRTANLYSLHSWLGIT 140
Cdd:cd08766     8 FNVHPVLMVIGFIFLAGEAILAYK---TVPGSREVQKAVHLTLHLVALVLGIVGIYAAFKFHNEVGIPNLYSLHSWLGIG 84


                  ....*...
gi 2217281666 141 TVFLFACQ 148
Cdd:cd08766    85 TISLFGLQ 92
PLN02680 PLN02680
carbon-monoxide oxygenase
 40-148 1.12e-21

carbon-monoxide oxygenase


Pssm-ID: 215365  Cd Length: 232  Bit Score: 88.70  E-value: 1.12e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217281666  40 FTIYWMQYWRGGFAW--NGSIYMFNWHPVLMVAGMVVFYGGASLVYRLPQswvGPKLPWKLLHAALHLMAFVLTVVGLVA 117
Cdd:PLN02680   24 LVLTWTVHYRGGLALssDNKDLIFNVHPVLMVIGLVLLNGEAMLAYKTVP---GTKNLKKLVHLTLQFLAFCLSLIGVWA 100

                          90       100       110
                  ....*....|....*....|....*....|.
gi 2217281666 118 VFTFHNHGRTANLYSLHSWLGITTVFLFACQ 148
Cdd:PLN02680  101 ALKFHNEKGIDNFYSLHSWLGLACLFLFSLQ 131
Cyt_b561_CYB561 cd08763
Vertebrate cytochrome b(561), CYB561 gene product; Cytochrome b(561), as found in vertebrates, ...
 54-148 5.98e-19

Vertebrate cytochrome b(561), CYB561 gene product; Cytochrome b(561), as found in vertebrates, which might act as a ferric-chelate reductase, catalyzing the reduction of Fe(3+) to Fe(2+), such as associated with the transport of iron from the endosome to the cytoplasm. It is assumed that this protein uses ascorbate as the electron donor. Belongs to the cytochrome b(561) family, which are secretory vesicle-specific electron transport proteins. Cytochromes b(561) are integral membrane proteins that bind two heme groups non-covalently, and may have six alpha-helical trans-membrane segments.


Pssm-ID: 176493  Cd Length: 143  Bit Score: 79.47  E-value: 5.98e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217281666  54 WNGSIyMFNWHPVLMVAGMVVFYGGASLVYRLPQSwvGPKLPWKLLHAALHLMAFVLTVVGLVAVFTFHNHGRTANLYSL 133
Cdd:cd08763     1 WSGPL-QFNVHPLCMVLGLVFLCGEALLVYRVFRN--ETKRSTKILHGLLHIMALVISLVGLVAVFDYHQANGYPDMYSL 77

                          90
                  ....*....|....*
gi 2217281666 134 HSWLGITTVFLFACQ 148
Cdd:cd08763    78 HSWCGILTFVLYFLQ 92
PLN02810 PLN02810
carbon-monoxide oxygenase
 44-148 1.41e-18

carbon-monoxide oxygenase


Pssm-ID: 178406  Cd Length: 231  Bit Score: 80.63  E-value: 1.41e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217281666  44 WMQYWRGGFAWNGS--IYMFNWHPVLMVAGMVVFYGGASLVYrlpQSWVGPKLPWKLLHAALHLMAFVLTVVGLVAVFTF 121
Cdd:PLN02810   28 WSIYYRGGLAWEATnkNLIFNLHPVLMLIGLIIIGGEAIMSY---KSLPLKKEVKKLIHLVLHAIALILGIFGICAAFKN 104

                          90       100
                  ....*....|....*....|....*..
gi 2217281666 122 HNHGRTANLYSLHSWLGITTVFLFACQ 148
Cdd:PLN02810  105 HNESGIANLYSLHSWLGIGIISLYGIQ 131
Cyt_b561_CYB561D2_like cd08761
Eukaryotic cytochrome b(561), including the CYB561D2 gene product; Cytochrome b(561), as found ...
 51-151 2.91e-08

Eukaryotic cytochrome b(561), including the CYB561D2 gene product; Cytochrome b(561), as found in eukaryotes, similar to and including the human CYB561D2 gene product. CYB561D2 is a candidate tumor suppressor. The protein might act as a ferric-chelate reductase, catalyzing the reduction of Fe(3+) to Fe(2+), such as associated with the transport of iron from the endosome to the cytoplasm. It is assumed that this protein uses ascorbate as the electron donor. Belongs to the cytochrome b(561) family, which are secretory vesicle-specific electron transport proteins. Cytochromes b(561) are integral membrane proteins that bind two heme groups non-covalently, and may have six alpha-helical trans-membrane segments.


Pssm-ID: 176491  Cd Length: 183  Bit Score: 51.52  E-value: 2.91e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217281666  51 GFAWNGSIYMFNWHPVLMVAGMVVFYGGASLVYRLPQSWVGPKLPWKL-LHAALHLMAFVLTVVGLVAVFTFHNHGRTAN 129
Cdd:cd08761    11 LYIARPGTSLFSWHPLLMSLGFLLLMTEALLLLQPTSSLTKLARKTKVrLHWILQLLALLCILAGLVAIYYNKERNGKPH 90

                          90       100
                  ....*....|....*....|..
gi 2217281666 130 LYSLHSWLGITTVFLFACQACA 151
Cdd:cd08761    91 FTSWHGILGLVTVILIVLQALG 112
PLN02351 PLN02351
cytochromes b561 family protein
 64-148 1.70e-07

cytochromes b561 family protein


Pssm-ID: 215201  Cd Length: 242  Bit Score: 49.91  E-value: 1.70e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217281666  64 HPVLMVAGMVVFYGGASLVYR-LPqswvGPKLPWKLLHAALHLMAFVLTVVGLVAVFTFhNHGRTANLYSLHSWLGITTV 142
Cdd:PLN02351   54 HPLLMVIGFILISGEAILVHRwLP----GSRKTKKSVHLWLQGLALASGVFGIWTKFHG-QDGIVANFYSLHSWMGLICV 128


                  ....*.
gi 2217281666 143 FLFACQ 148
Cdd:PLN02351  129 SLFGAQ 134
Cyt_b561_FRRS1_like cd08760
Eukaryotic cytochrome b(561), including the FRRS1 gene product; Cytochrome b(561), as found in ...
 47-151 2.27e-07

Eukaryotic cytochrome b(561), including the FRRS1 gene product; Cytochrome b(561), as found in eukaryotes, similar to and including the human FRRS1 gene product (ferric-chelate reductase 1), also called SDR-2 (stromal cell-derived receptor 2). This family comprises a variety of domain architectures, many of which contain dopamine beta-monooxygenase (DOMON) domains. The protein might act as a ferric-chelate reductase, catalyzing the reduction of Fe(3+) to Fe(2+), such as associated with the transport of iron from the endosome to the cytoplasm. It is assumed that this protein uses ascorbate as the electron donor. Belongs to the cytochrome b(561) family, which are secretory vesicle-specific electron transport proteins. Cytochromes b(561) are integral membrane proteins that bind two heme groups non-covalently, and may have six alpha-helical trans-membrane segments.


Pssm-ID: 176490  Cd Length: 191  Bit Score: 49.27  E-value: 2.27e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217281666  47 YWRGGFAWNGSIYMFNWHPVLMVAGMVVFYGGASLVYRLpqSWVGPKLpWKLLHAALHLMAFVLTVVGLVAVFtFHNHGR 126
Cdd:cd08760    22 LLPNGSSVGSSDTLIKAHGVLMAIAWGILMPIGALLARY--FLLGDPV-WFYLHAGLQLLAVLLAIAGFVLGI-VLVQGG 97

                          90       100
                  ....*....|....*....|....*
gi 2217281666 127 TANLYSLHSWLGITTVFLFACQACA 151
Cdd:cd08760    98 GGSLNNAHAILGIIVLALAILQPLL 122
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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