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Conserved domains on  [gi|1370459290|ref|XP_024304256|]
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doublecortin domain-containing protein 1 isoform X6 [Homo sapiens]

Protein Classification

DCX_DCDC1 and DCX2_DCDC5 domain-containing protein( domain architecture ID 13019604)

DCX_DCDC1 and DCX2_DCDC5 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DCX_DCDC1 cd17155
Doublecortin-like domain found in doublecortin domain-containing protein 1 (DCDC1); ...
 174-245 2.83e-44

Doublecortin-like domain found in doublecortin domain-containing protein 1 (DCDC1); Doublecortin (DCX) is a microtubule-associated protein (MAP) with a stable ubiquitin-like tertiary fold. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCX gene family consists of eleven paralogs in human and mouse, such that its protein domains can occur in tandem or single repeats. Proteins with DCX tandem domains in general have roles in microtubule (MT) regulation and signal transduction while single DCX repeat proteins are normally localized to actin-rich subcellular structures or to the nucleus. DCDC1 is a hydrophilic intracellular protein that contains only one DCX repeat. Therefore, DCDC1 might only bind to microtubules without microtubule polymerization properties. DCDC1 is mainly expressed in adult testis.


:

Pssm-ID: 340675  Cd Length: 72  Bit Score: 150.62  E-value: 2.83e-44
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1370459290 174 IKVTAYKNGSRTVFARVTVPTITLLLEECTEKLNLNMAARRVFLADGKEALEPEDIPHEADVYVSTGEPFLN 245
Cdd:cd17155     1 IKVTAFKNGTRDVFAKVTAPNIKILLEECTEKLGLNSAARRVFLADGTEVFEPKDIPRDADVYISTGEPFKD 72
DCX2_DCDC5 cd17157
Doublecortin-like domain 2 found in doublecortin domain-containing protein 5 (DCDC5); DCDC5 is ...
 295-380 1.56e-42

Doublecortin-like domain 2 found in doublecortin domain-containing protein 5 (DCDC5); DCDC5 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC5 is expressed during mitosis and involved in coordinating late cytokinesis. DCDC5 interacts with cytoplasmic dynein and Rab8, as well as with the Rab8 nucleotide exchange factor Rabin8.


:

Pssm-ID: 340677  Cd Length: 86  Bit Score: 146.34  E-value: 1.56e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370459290 295 VRILFFKNGMGQDGHEITVGKETMKKVLDTCTIRMNLNLPARYFYDLYGRKIEDISKVPLLEKCLQNSITPLRGLLWVSK 374
Cdd:cd17157     1 RRILVFKNGDGSEGYEIVADLDEFEQFLDACTSKLNLGSPARVLYDWEGKEIKDLSEAPKLDKCLQNSSTPVLGPLWVSK 80


                  ....*.
gi 1370459290 375 GEGFSP 380
Cdd:cd17157    81 GEGFSP 86
 
Name Accession Description Interval E-value
DCX_DCDC1 cd17155
Doublecortin-like domain found in doublecortin domain-containing protein 1 (DCDC1); ...
 174-245 2.83e-44

Doublecortin-like domain found in doublecortin domain-containing protein 1 (DCDC1); Doublecortin (DCX) is a microtubule-associated protein (MAP) with a stable ubiquitin-like tertiary fold. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCX gene family consists of eleven paralogs in human and mouse, such that its protein domains can occur in tandem or single repeats. Proteins with DCX tandem domains in general have roles in microtubule (MT) regulation and signal transduction while single DCX repeat proteins are normally localized to actin-rich subcellular structures or to the nucleus. DCDC1 is a hydrophilic intracellular protein that contains only one DCX repeat. Therefore, DCDC1 might only bind to microtubules without microtubule polymerization properties. DCDC1 is mainly expressed in adult testis.


Pssm-ID: 340675  Cd Length: 72  Bit Score: 150.62  E-value: 2.83e-44
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1370459290 174 IKVTAYKNGSRTVFARVTVPTITLLLEECTEKLNLNMAARRVFLADGKEALEPEDIPHEADVYVSTGEPFLN 245
Cdd:cd17155     1 IKVTAFKNGTRDVFAKVTAPNIKILLEECTEKLGLNSAARRVFLADGTEVFEPKDIPRDADVYISTGEPFKD 72
DCX2_DCDC5 cd17157
Doublecortin-like domain 2 found in doublecortin domain-containing protein 5 (DCDC5); DCDC5 is ...
 295-380 1.56e-42

Doublecortin-like domain 2 found in doublecortin domain-containing protein 5 (DCDC5); DCDC5 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC5 is expressed during mitosis and involved in coordinating late cytokinesis. DCDC5 interacts with cytoplasmic dynein and Rab8, as well as with the Rab8 nucleotide exchange factor Rabin8.


Pssm-ID: 340677  Cd Length: 86  Bit Score: 146.34  E-value: 1.56e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370459290 295 VRILFFKNGMGQDGHEITVGKETMKKVLDTCTIRMNLNLPARYFYDLYGRKIEDISKVPLLEKCLQNSITPLRGLLWVSK 374
Cdd:cd17157     1 RRILVFKNGDGSEGYEIVADLDEFEQFLDACTSKLNLGSPARVLYDWEGKEIKDLSEAPKLDKCLQNSSTPVLGPLWVSK 80


                  ....*.
gi 1370459290 375 GEGFSP 380
Cdd:cd17157    81 GEGFSP 86
DCX smart00537
Domain in the Doublecortin (DCX) gene product; Tandemly-repeated domain in doublin, the ...
 170-252 7.76e-04

Domain in the Doublecortin (DCX) gene product; Tandemly-repeated domain in doublin, the Doublecortin gene product. Proposed to bind tubulin. Doublecortin (DCX) is mutated in human X-linked neuronal migration defects.


Pssm-ID: 214711  Cd Length: 89  Bit Score: 38.78  E-value: 7.76e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370459290  170 QPRVIKVTAYKNG------SRTVFARVTVPTITLLLEECTE--KLNLNMAARRVFLADGKEALEPEDIpHEADVYVSTGE 241
Cdd:smart00537   2 LVKPKRIRFYRNGdrffkgVRLVVNRKRFKSFEALLQDLTEvvKLDLPHGVRKLYTLDGKKVTSLDEL-EDGGSYVASGT 80

                           90
                   ....*....|.
gi 1370459290  242 pflNPFKKIKD 252
Cdd:smart00537  81 ---EAFKKVDY 88
 
Name Accession Description Interval E-value
DCX_DCDC1 cd17155
Doublecortin-like domain found in doublecortin domain-containing protein 1 (DCDC1); ...
 174-245 2.83e-44

Doublecortin-like domain found in doublecortin domain-containing protein 1 (DCDC1); Doublecortin (DCX) is a microtubule-associated protein (MAP) with a stable ubiquitin-like tertiary fold. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCX gene family consists of eleven paralogs in human and mouse, such that its protein domains can occur in tandem or single repeats. Proteins with DCX tandem domains in general have roles in microtubule (MT) regulation and signal transduction while single DCX repeat proteins are normally localized to actin-rich subcellular structures or to the nucleus. DCDC1 is a hydrophilic intracellular protein that contains only one DCX repeat. Therefore, DCDC1 might only bind to microtubules without microtubule polymerization properties. DCDC1 is mainly expressed in adult testis.


Pssm-ID: 340675  Cd Length: 72  Bit Score: 150.62  E-value: 2.83e-44
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1370459290 174 IKVTAYKNGSRTVFARVTVPTITLLLEECTEKLNLNMAARRVFLADGKEALEPEDIPHEADVYVSTGEPFLN 245
Cdd:cd17155     1 IKVTAFKNGTRDVFAKVTAPNIKILLEECTEKLGLNSAARRVFLADGTEVFEPKDIPRDADVYISTGEPFKD 72
DCX2_DCDC5 cd17157
Doublecortin-like domain 2 found in doublecortin domain-containing protein 5 (DCDC5); DCDC5 is ...
 295-380 1.56e-42

Doublecortin-like domain 2 found in doublecortin domain-containing protein 5 (DCDC5); DCDC5 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC5 is expressed during mitosis and involved in coordinating late cytokinesis. DCDC5 interacts with cytoplasmic dynein and Rab8, as well as with the Rab8 nucleotide exchange factor Rabin8.


Pssm-ID: 340677  Cd Length: 86  Bit Score: 146.34  E-value: 1.56e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370459290 295 VRILFFKNGMGQDGHEITVGKETMKKVLDTCTIRMNLNLPARYFYDLYGRKIEDISKVPLLEKCLQNSITPLRGLLWVSK 374
Cdd:cd17157     1 RRILVFKNGDGSEGYEIVADLDEFEQFLDACTSKLNLGSPARVLYDWEGKEIKDLSEAPKLDKCLQNSSTPVLGPLWVSK 80


                  ....*.
gi 1370459290 375 GEGFSP 380
Cdd:cd17157    81 GEGFSP 86
DCX_DCDC5_like cd17072
Doublecortin-like domain found in doublecortin domain-containing protein 5 (DCDC5) and similar ...
 174-240 2.05e-21

Doublecortin-like domain found in doublecortin domain-containing protein 5 (DCDC5) and similar proteins; DCDC5 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC5 is expressed during mitosis and involved in coordinating late cytokinesis. DCDC5 interacts with cytoplasmic dynein and Rab8 as well as with the Rab8 nucleotide exchange factor Rabin8. This family also includes DCDC1, which is a hydrophilic intracellular protein that contains only one DCX repeat. Therefore, DCDC1 might only bind to microtubules without microtubule polymerization properties. DCDC1 is mainly expressed in adult testis.


Pssm-ID: 340592  Cd Length: 71  Bit Score: 88.10  E-value: 2.05e-21
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1370459290 174 IKVTAYKNGSR--TVFARVTVP--TITLLLEECTEKLNLNMAARRVFLADGKEALEPEDIPHEADVYVSTG 240
Cdd:cd17072     1 VRLRVLKNGERdlERAVYVVGPdlELQLFLDRCTERLNLPFAARRLFDENGKEIFTLRDLERDQLVYVSCG 71
DCX_DCDC5_like cd17072
Doublecortin-like domain found in doublecortin domain-containing protein 5 (DCDC5) and similar ...
 295-375 2.47e-16

Doublecortin-like domain found in doublecortin domain-containing protein 5 (DCDC5) and similar proteins; DCDC5 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC5 is expressed during mitosis and involved in coordinating late cytokinesis. DCDC5 interacts with cytoplasmic dynein and Rab8 as well as with the Rab8 nucleotide exchange factor Rabin8. This family also includes DCDC1, which is a hydrophilic intracellular protein that contains only one DCX repeat. Therefore, DCDC1 might only bind to microtubules without microtubule polymerization properties. DCDC1 is mainly expressed in adult testis.


Pssm-ID: 340592  Cd Length: 71  Bit Score: 73.46  E-value: 2.47e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370459290 295 VRILFFKNGMG--QDGHEITVGKETMKKVLDTCTIRMNLNLPARYFYDLYGRKIEDIskvpllekclqnSITPLRGLLWV 372
Cdd:cd17072     1 VRLRVLKNGERdlERAVYVVGPDLELQLFLDRCTERLNLPFAARRLFDENGKEIFTL------------RDLERDQLVYV 68


                  ...
gi 1370459290 373 SKG 375
Cdd:cd17072    69 SCG 71
DCX1_DCDC5 cd17156
Doublecortin-like domain 1 found in doublecortin domain-containing protein 5 (DCDC5); DCDC5 is ...
 174-246 6.15e-12

Doublecortin-like domain 1 found in doublecortin domain-containing protein 5 (DCDC5); DCDC5 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC5 is expressed during mitosis and is involved in coordinating late cytokinesis. DCDC5 interacts with cytoplasmic dynein and Rab8, as well as with the Rab8 nucleotide exchange factor Rabin8.


Pssm-ID: 340676  Cd Length: 76  Bit Score: 61.15  E-value: 6.15e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1370459290 174 IKVTAYKNGSRTVFARVTVPTIT-LLLEECTEKLNLNMAARRVFLADGKEALEPEDIPHEADVYVSTGEPFLNP 246
Cdd:cd17156     1 LRLRVLRNGEKDKNKAVTVVGEFqLFLERCTTALNLPFAARRLFDEKGKEHFTLKDLKRDQLVYVSCGEAWIDP 74
DCX3_DCDC5 cd17158
Doublecortin-like domain 3 found in doublecortin domain-containing protein 5 (DCDC5); DCDC5 is ...
 174-244 2.67e-11

Doublecortin-like domain 3 found in doublecortin domain-containing protein 5 (DCDC5); DCDC5 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC5 is expressed during mitosis and involved in coordinating late cytokinesis. DCDC5 interacts with cytoplasmic dynein and Rab8, as well as with the Rab8 nucleotide exchange factor Rabin8.


Pssm-ID: 340678  Cd Length: 73  Bit Score: 59.25  E-value: 2.67e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1370459290 174 IKVTAYKNGSRTVFARVTV--PTITLLLEECTEKLNLNMAARRVFLADGKEALePEDIPHEADVYVSTGEPFL 244
Cdd:cd17158     1 VKILAYKNGEGRLRDGVLIigSTFPGLLDQCTHRLGLARAARRLYTADGTLIL-TLILRYPIEVWVSCGEPFI 72
DCX4_DCDC5 cd17159
Doublecortin-like domain 4 found in doublecortin domain-containing protein 5 (DCDC5); DCDC5 is ...
 175-245 1.39e-07

Doublecortin-like domain 4 found in doublecortin domain-containing protein 5 (DCDC5); DCDC5 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC5 is expressed during mitosis and involved in coordinating late cytokinesis. DCDC5 interacts with cytoplasmic dynein and Rab8, as well as with the Rab8 nucleotide exchange factor Rabin8.


Pssm-ID: 340679  Cd Length: 73  Bit Score: 48.83  E-value: 1.39e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1370459290 175 KVTAYKNGS---RTVFARVTvpTITLLLEECTEKLNLNMAARRVFLADGKEALEPEDIPHEADVYVSTGEPFLN 245
Cdd:cd17159     2 RVLVYPNGGspeRAVYAWGK--SIEELLDSCTERLGLRKPAKYLYTPDGEQIQSWDDIERDMLLCVSTGEPFLT 73
DCX3_DCDC5 cd17158
Doublecortin-like domain 3 found in doublecortin domain-containing protein 5 (DCDC5); DCDC5 is ...
 295-380 1.90e-07

Doublecortin-like domain 3 found in doublecortin domain-containing protein 5 (DCDC5); DCDC5 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC5 is expressed during mitosis and involved in coordinating late cytokinesis. DCDC5 interacts with cytoplasmic dynein and Rab8, as well as with the Rab8 nucleotide exchange factor Rabin8.


Pssm-ID: 340678  Cd Length: 73  Bit Score: 48.46  E-value: 1.90e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370459290 295 VRILFFKNGMG--QDGHEITVGkeTMKKVLDTCTIRMNLNLPARYFYDLYGRKIEDIskvpllekCLQNSITplrglLWV 372
Cdd:cd17158     1 VKILAYKNGEGrlRDGVLIIGS--TFPGLLDQCTHRLGLARAARRLYTADGTLILTL--------ILRYPIE-----VWV 65


                  ....*...
gi 1370459290 373 SKGEGFSP 380
Cdd:cd17158    66 SCGEPFIP 73
DCX4_DCDC5 cd17159
Doublecortin-like domain 4 found in doublecortin domain-containing protein 5 (DCDC5); DCDC5 is ...
 296-379 1.99e-07

Doublecortin-like domain 4 found in doublecortin domain-containing protein 5 (DCDC5); DCDC5 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC5 is expressed during mitosis and involved in coordinating late cytokinesis. DCDC5 interacts with cytoplasmic dynein and Rab8, as well as with the Rab8 nucleotide exchange factor Rabin8.


Pssm-ID: 340679  Cd Length: 73  Bit Score: 48.45  E-value: 1.99e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370459290 296 RILFFKNGmGQDGHEITVGKETMKKVLDTCTIRMNLNLPARYFYDLYGRKIEDISKVpllEKCLqnsitplrgLLWVSKG 375
Cdd:cd17159     2 RVLVYPNG-GSPERAVYAWGKSIEELLDSCTERLGLRKPAKYLYTPDGEQIQSWDDI---ERDM---------LLCVSTG 68


                  ....
gi 1370459290 376 EGFS 379
Cdd:cd17159    69 EPFL 72
DCX smart00537
Domain in the Doublecortin (DCX) gene product; Tandemly-repeated domain in doublin, the ...
 170-252 7.76e-04

Domain in the Doublecortin (DCX) gene product; Tandemly-repeated domain in doublin, the Doublecortin gene product. Proposed to bind tubulin. Doublecortin (DCX) is mutated in human X-linked neuronal migration defects.


Pssm-ID: 214711  Cd Length: 89  Bit Score: 38.78  E-value: 7.76e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370459290  170 QPRVIKVTAYKNG------SRTVFARVTVPTITLLLEECTE--KLNLNMAARRVFLADGKEALEPEDIpHEADVYVSTGE 241
Cdd:smart00537   2 LVKPKRIRFYRNGdrffkgVRLVVNRKRFKSFEALLQDLTEvvKLDLPHGVRKLYTLDGKKVTSLDEL-EDGGSYVASGT 80

                           90
                   ....*....|.
gi 1370459290  242 pflNPFKKIKD 252
Cdd:smart00537  81 ---EAFKKVDY 88
DCX cd01617
Dublecortin-like domain structurally similar to a beta-grasp ubiquitin-like fold; Dublecortin ...
 174-238 1.54e-03

Dublecortin-like domain structurally similar to a beta-grasp ubiquitin-like fold; Dublecortin (DCX) is a microtubule-associated protein (MAP) with a stable ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. The DCX gene family consists of eleven paralogs in human and mouse, and its DCX protein domains can occur in double tandem or as single DCX repeats. Proteins with DCX tandem domains in general have roles in microtubule (MT) regulation and signal transduction such as X-linked doublecortin (DCX), retinitis pigmentosa-1 (RP1) and doublecortin-like kinase (DCLK). Single DCX repeat proteins are normally localized to actin-rich subcellular structures, or the nucleus such as DCDC2. DCX is not only a unique MAP in terms of structure, it also interacts with multiple additional proteins. Mutations in human DCX genes are associated with abnormal neuronal migration, epilepsy, and mental retardation.


Pssm-ID: 340456  Cd Length: 73  Bit Score: 37.21  E-value: 1.54e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1370459290 174 IKVTAYKNGSR----TVFA--RVTVPTITLLLEECTEKLNLNM-AARRVFLADGKEALEPEDIPHEADVYVS 238
Cdd:cd01617     1 KRITVFRNGDKnfkgVKVLvkPRRFRTFDQLLDELTEKLGLPTgGVRKLYTPSGKLVKSLSDLEDGESYVVC 72
DCX_DCDC1 cd17155
Doublecortin-like domain found in doublecortin domain-containing protein 1 (DCDC1); ...
 295-336 6.48e-03

Doublecortin-like domain found in doublecortin domain-containing protein 1 (DCDC1); Doublecortin (DCX) is a microtubule-associated protein (MAP) with a stable ubiquitin-like tertiary fold. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCX gene family consists of eleven paralogs in human and mouse, such that its protein domains can occur in tandem or single repeats. Proteins with DCX tandem domains in general have roles in microtubule (MT) regulation and signal transduction while single DCX repeat proteins are normally localized to actin-rich subcellular structures or to the nucleus. DCDC1 is a hydrophilic intracellular protein that contains only one DCX repeat. Therefore, DCDC1 might only bind to microtubules without microtubule polymerization properties. DCDC1 is mainly expressed in adult testis.


Pssm-ID: 340675  Cd Length: 72  Bit Score: 35.44  E-value: 6.48e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1370459290 295 VRILFFKNGMGQDGHEITVgkETMKKVLDTCTIRMNLNLPAR 336
Cdd:cd17155     1 IKVTAFKNGTRDVFAKVTA--PNIKILLEECTEKLGLNSAAR 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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