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Conserved domains on  [gi|1370465210|ref|XP_024305407|]
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serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X3 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PPP2R3C cd21505
serine/threonine protein phosphatase 2A regulatory subunit B" subunit gamma; Heterotrimeric ...
 9-385 0e+00

serine/threonine protein phosphatase 2A regulatory subunit B" subunit gamma; Heterotrimeric serine/threonine protein phosphatase 2A (PP2A) consists of scaffolding (A), catalytic (C), and variable (B, B', and B") subunits. The variable subunits dictate subcellular localization and substrate specificity of the PP2A holoenzyme. This subfamily includes protein phosphatase subunit G5PR (also known as serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma, G4-1, G5pr, GDRM, SPGF36, or C14orf10) that is encoded by the PPP2R3C gene. It is involved in the control of the dynamic organization of the cortical cytoskeleton and plays an important role in the organization of interphase microtubule arrays in part through the regulation of nucleation geometry. G5PR is involved in the ontogeny of multiple organs, especially critical for testis development and spermatogenesis. PPP2R3C gene variants cause syndromic 46,XY gonadal dysgenesis and impaired spermatogenesis in humans, and thus is emerging as a potential therapeutic target for male infertility.


:

Pssm-ID: 410338 [Multi-domain]  Cd Length: 382  Bit Score: 710.88  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465210   9 LQLPAEDEVLLQKLREESRAVFLQRKSRELLDNEELQNLWFLLDKHQTPPMIGEEAMINYENFLKVGEKAGAKCKQFFTA 88
Cdd:cd21505     6 FKKPSESSVLLQKLREEARARFLQRKSSELLDNDELQELWYLLLEHHVPPDSGEEERINYEDFLKVREEAGPKCRPFFTP 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465210  89 KVFAKLLHTDSYGRISIMQFFNYVMRKVWLHQTRIGLSLYDVAGQGYLRESDLENYILELIPTLPQLDGLEKSFYSFYVC 168
Cdd:cd21505    86 SVFLKLLRDDPYGRISIMQFFNYVMRKVWLHQTRIGLSLYDVDGDGFLTESDLENYILELIPTLPQLSGLEESFYSFYVC 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465210 169 TAVRKFFFFLDPLRTGKIKIQDILACSFLDDLLELRDEELSKESQETNWFSAPSALRVYGQYLNLDKDHNGMLSKEELSR 248
Cdd:cd21505   166 TAVRKFFFFLDPLRRGKIRIKDILASPFLDELLELRDEELSEELQESNWFSAPSALRVYGQYLNLDKDHNGMLSKQELSR 245

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465210 249 YGTATMTNVFLDRVFQECLTYDGEMDYKTYLDFVLALENRKEPAALQYIFKLLDIENKGYLNVFSLNYFFRAIQELMKIH 328
Cdd:cd21505   246 YGKGTLTSVFIDRVFQECLTYNGEMDYKTFLDFVLAMENRKEPQALQYFFRILDLKGQGYLTPFTLNYFFRAIQEKMKEH 325

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1370465210 329 GQDPVSFQDVKDEIFDMVKPKDPLKISLQDLINSNQGDTVTTILIDLNGFWTYENRE 385
Cdd:cd21505   326 GQEPVSFEDVKDEIFDMVKPKDPLKITLQDLINSGQGDTVVSILIDLNGFWAYENRE 382
 
Name Accession Description Interval E-value
PPP2R3C cd21505
serine/threonine protein phosphatase 2A regulatory subunit B" subunit gamma; Heterotrimeric ...
 9-385 0e+00

serine/threonine protein phosphatase 2A regulatory subunit B" subunit gamma; Heterotrimeric serine/threonine protein phosphatase 2A (PP2A) consists of scaffolding (A), catalytic (C), and variable (B, B', and B") subunits. The variable subunits dictate subcellular localization and substrate specificity of the PP2A holoenzyme. This subfamily includes protein phosphatase subunit G5PR (also known as serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma, G4-1, G5pr, GDRM, SPGF36, or C14orf10) that is encoded by the PPP2R3C gene. It is involved in the control of the dynamic organization of the cortical cytoskeleton and plays an important role in the organization of interphase microtubule arrays in part through the regulation of nucleation geometry. G5PR is involved in the ontogeny of multiple organs, especially critical for testis development and spermatogenesis. PPP2R3C gene variants cause syndromic 46,XY gonadal dysgenesis and impaired spermatogenesis in humans, and thus is emerging as a potential therapeutic target for male infertility.


Pssm-ID: 410338 [Multi-domain]  Cd Length: 382  Bit Score: 710.88  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465210   9 LQLPAEDEVLLQKLREESRAVFLQRKSRELLDNEELQNLWFLLDKHQTPPMIGEEAMINYENFLKVGEKAGAKCKQFFTA 88
Cdd:cd21505     6 FKKPSESSVLLQKLREEARARFLQRKSSELLDNDELQELWYLLLEHHVPPDSGEEERINYEDFLKVREEAGPKCRPFFTP 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465210  89 KVFAKLLHTDSYGRISIMQFFNYVMRKVWLHQTRIGLSLYDVAGQGYLRESDLENYILELIPTLPQLDGLEKSFYSFYVC 168
Cdd:cd21505    86 SVFLKLLRDDPYGRISIMQFFNYVMRKVWLHQTRIGLSLYDVDGDGFLTESDLENYILELIPTLPQLSGLEESFYSFYVC 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465210 169 TAVRKFFFFLDPLRTGKIKIQDILACSFLDDLLELRDEELSKESQETNWFSAPSALRVYGQYLNLDKDHNGMLSKEELSR 248
Cdd:cd21505   166 TAVRKFFFFLDPLRRGKIRIKDILASPFLDELLELRDEELSEELQESNWFSAPSALRVYGQYLNLDKDHNGMLSKQELSR 245

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465210 249 YGTATMTNVFLDRVFQECLTYDGEMDYKTYLDFVLALENRKEPAALQYIFKLLDIENKGYLNVFSLNYFFRAIQELMKIH 328
Cdd:cd21505   246 YGKGTLTSVFIDRVFQECLTYNGEMDYKTFLDFVLAMENRKEPQALQYFFRILDLKGQGYLTPFTLNYFFRAIQEKMKEH 325

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1370465210 329 GQDPVSFQDVKDEIFDMVKPKDPLKISLQDLINSNQGDTVTTILIDLNGFWTYENRE 385
Cdd:cd21505   326 GQEPVSFEDVKDEIFDMVKPKDPLKITLQDLINSGQGDTVVSILIDLNGFWAYENRE 382
EF-hand_13 pfam17958
EF-hand domain; This entry represents an EF-hand domain found in one of the regulatory B ...
 132-206 5.48e-04

EF-hand domain; This entry represents an EF-hand domain found in one of the regulatory B subunits of PP2A.


Pssm-ID: 465586 [Multi-domain]  Cd Length: 90  Bit Score: 38.88  E-value: 5.48e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1370465210 132 GQGYLRESDLENYILELIPTLPQLDGLEKS--FYSFYVCTAVRKFFFFLDPLRTGKIKIQDILACSFLDDLLELRDE 206
Cdd:pfam17958  14 GKNYLSREDFYPFVQDVVDTHPGLEFLREAeeFQDKYIQTVIARIFYVVNRSWSGKITLLELRKSDLLKAVRQLDEE 90
 
Name Accession Description Interval E-value
PPP2R3C cd21505
serine/threonine protein phosphatase 2A regulatory subunit B" subunit gamma; Heterotrimeric ...
 9-385 0e+00

serine/threonine protein phosphatase 2A regulatory subunit B" subunit gamma; Heterotrimeric serine/threonine protein phosphatase 2A (PP2A) consists of scaffolding (A), catalytic (C), and variable (B, B', and B") subunits. The variable subunits dictate subcellular localization and substrate specificity of the PP2A holoenzyme. This subfamily includes protein phosphatase subunit G5PR (also known as serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma, G4-1, G5pr, GDRM, SPGF36, or C14orf10) that is encoded by the PPP2R3C gene. It is involved in the control of the dynamic organization of the cortical cytoskeleton and plays an important role in the organization of interphase microtubule arrays in part through the regulation of nucleation geometry. G5PR is involved in the ontogeny of multiple organs, especially critical for testis development and spermatogenesis. PPP2R3C gene variants cause syndromic 46,XY gonadal dysgenesis and impaired spermatogenesis in humans, and thus is emerging as a potential therapeutic target for male infertility.


Pssm-ID: 410338 [Multi-domain]  Cd Length: 382  Bit Score: 710.88  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465210   9 LQLPAEDEVLLQKLREESRAVFLQRKSRELLDNEELQNLWFLLDKHQTPPMIGEEAMINYENFLKVGEKAGAKCKQFFTA 88
Cdd:cd21505     6 FKKPSESSVLLQKLREEARARFLQRKSSELLDNDELQELWYLLLEHHVPPDSGEEERINYEDFLKVREEAGPKCRPFFTP 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465210  89 KVFAKLLHTDSYGRISIMQFFNYVMRKVWLHQTRIGLSLYDVAGQGYLRESDLENYILELIPTLPQLDGLEKSFYSFYVC 168
Cdd:cd21505    86 SVFLKLLRDDPYGRISIMQFFNYVMRKVWLHQTRIGLSLYDVDGDGFLTESDLENYILELIPTLPQLSGLEESFYSFYVC 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465210 169 TAVRKFFFFLDPLRTGKIKIQDILACSFLDDLLELRDEELSKESQETNWFSAPSALRVYGQYLNLDKDHNGMLSKEELSR 248
Cdd:cd21505   166 TAVRKFFFFLDPLRRGKIRIKDILASPFLDELLELRDEELSEELQESNWFSAPSALRVYGQYLNLDKDHNGMLSKQELSR 245

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465210 249 YGTATMTNVFLDRVFQECLTYDGEMDYKTYLDFVLALENRKEPAALQYIFKLLDIENKGYLNVFSLNYFFRAIQELMKIH 328
Cdd:cd21505   246 YGKGTLTSVFIDRVFQECLTYNGEMDYKTFLDFVLAMENRKEPQALQYFFRILDLKGQGYLTPFTLNYFFRAIQEKMKEH 325

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1370465210 329 GQDPVSFQDVKDEIFDMVKPKDPLKISLQDLINSNQGDTVTTILIDLNGFWTYENRE 385
Cdd:cd21505   326 GQEPVSFEDVKDEIFDMVKPKDPLKITLQDLINSGQGDTVVSILIDLNGFWAYENRE 382
PPP2R3 cd21339
serine/threonine protein phosphatase 2A regulatory subunit B"; Heterotrimeric serine/threonine ...
 119-381 1.57e-135

serine/threonine protein phosphatase 2A regulatory subunit B"; Heterotrimeric serine/threonine protein phosphatase 2A (PP2A) consists of scaffolding (A), catalytic (C), and variable (B, B', and B") subunits. The variable subunits dictate subcellular localization and substrate specificity of the PP2A holoenzyme. This family includes PP2A regulatory B'' subunits alpha, beta and gamma, encoded by PPP2R3A, PPP2R3B and PPP2R3C, respectively. It also includes subunit delta encoded by PPP2R3D in mouse. These B-family regulatory subunits play various roles including regulation of cytoskeletal assembly, neuronal differentiation, mitogen-activated protein kinase signaling, and apoptosis. Subunits alpha and beta contain two-domain elongated structure with two calcium EF-hands which mediate Ca2+-dependent changes in phosphatase activity.


Pssm-ID: 410336  Cd Length: 259  Bit Score: 388.09  E-value: 1.57e-135
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465210 119 HQTRIGLSLYDvAGQGYLRESDLENYILELIPTLPQLDGLEK--SFYSFYVCTAVRKFFFFLDPLRTGKIKIQDILACSF 196
Cdd:cd21339     1 DATKFGLLLYD-PGCGYLRQEDFEPYLQDVVPTHPGLDFLKKapEFHSRYITTVIQRIFYFVNRSWSGKITIQEIRASSF 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465210 197 LDDLLELRDEELSKesQETNWFSAPSALRVYGQYLNLDKDHNGMLSKEELSRYGTATMTNVFLDRVFQECLTY------D 270
Cdd:cd21339    80 LQDLALLEEEEDIN--QETNWFSYEHFYVIYCKFWELDTDHDLMISKEDLSRYNDAAMSNVFIDRIFSGAVTRgktiqkE 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465210 271 GEMDYKTYLDFVLALENRKEPAALQYIFKLLDIENKGYLNVFSLNYFFRAIQELMKIHGQDPVSFQDVKDEIFDMVKPKD 350
Cdd:cd21339   158 GEMSYADFVWFLISEEDKKEPTSIEYWFRCLDIDGDGYLSVFELEYFYEEQCERMKIHGIEPLPFQDVLCQILDLVKPKD 237

                         250       260       270
                  ....*....|....*....|....*....|.
gi 1370465210 351 PLKISLQDLINSNqgdtvttilIDLNGFWTY 381
Cdd:cd21339   238 PGKITLQDLKRCN---------IALNFFDTF 259
PPP2R3A_B-like cd21504
serine/threonine protein phosphatase 2A regulatory subunit B" alpha and beta subunits, and ...
 135-378 4.78e-33

serine/threonine protein phosphatase 2A regulatory subunit B" alpha and beta subunits, and similar proteins; Heterotrimeric serine/threonine protein phosphatase 2A (PP2A) consists of scaffolding (A), catalytic (C), and variable (B, B', and B") subunits. The variable subunits dictate subcellular localization and substrate specificity of the PP2A holoenzyme. These B-family regulatory subunits play various roles including regulation of cytoskeletal assembly, neuronal differentiation, mitogen-activated protein kinase signaling, and apoptosis. This subfamily includes protein phosphatase 2A regulatory subunit B'' subunits alpha and beta, encoded by PPP2R3A and PPP2R3B. It also includes subunit delta encoded by PPP2R3D in mouse. They contain two-domain elongated structures with two calcium EF-hands which mediate Ca2+-dependent changes in phosphatase activity.


Pssm-ID: 410337  Cd Length: 274  Bit Score: 124.97  E-value: 4.78e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465210 135 YLRESDLENYILELIPTLPQLDGLEKS--FYSFYVCTAVRKFFFFLDPLRTGKIKIQDILACSFLDDLLELRDEElsKES 212
Cdd:cd21504    26 YLVPEDFKPFLQDLLDTHPGLEFLQDTpeFQERYAETVIYRIFYSVNRSWSGRITLRELRRSNLLQALLLLDEEE--DIN 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465210 213 QETNWFSAPSALRVYGQYLNLDKDHNGMLSKEELSRYGTATMTNVFLDRVFQECLT-----YDGEMDYKTYLDFVLALEN 287
Cdd:cd21504   104 KVLRYFSYEHFYVIYCKFWELDTDHDLLIDKDDLLRYGDHALSPRIVDRIFSGAVRrfksgKEGKMSYEDFVWFILSEED 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465210 288 RKEPAALQYIFKLLDIENKGYLNVFSLNYFFRAIQELMKIHGQDPVSFQDVKDEIFDMVKPKDPLKISLQDLINSNQGDT 367
Cdd:cd21504   184 KTSPTSIEYWFRCMDLDGDGVLSMYEMEYFYEEQLQRMECLGIEPVPFEDILCQMLDMIKPENEGKITLRDLKRCKLAGN 263

                         250
                  ....*....|.
gi 1370465210 368 VTTILIDLNGF 378
Cdd:cd21504   264 FFNTLFNLNKF 274
PPP2R3A cd21506
serine/threonine protein phosphatase 2A regulatory subunit B" subunit alpha; Heterotrimeric ...
 132-385 7.06e-33

serine/threonine protein phosphatase 2A regulatory subunit B" subunit alpha; Heterotrimeric serine/threonine protein phosphatase 2A (PP2A) consists of scaffolding (A), catalytic (C), and variable (B, B', and B") subunits. The variable subunits dictate subcellular localization and substrate specificity of the PP2A holoenzyme. This group contains protein phosphatase subunit PR130 (also known as protein phosphatase 2A regulatory subunit B'' subunit alpha, PR72, or PPP2R3) that is encoded by the PPP2R3A gene. PR130 and PR72 subunits are derived from the same gene through differential splicing; they harbor specific N-terminal domains of different lengths that are encoded by alternatively spliced exons and have identical C-termini. The common C-terminus contains a two-domain elongated structure with two calcium EF-hands which mediate Ca2+-dependent changes in phosphatase activity. The PR130 subunit has been shown to interact with the LIM domain of lipoma-preferred partner (LPP) through a conserved Zn2+-finger-like motif in the N-terminus of PR130.


Pssm-ID: 410339  Cd Length: 284  Bit Score: 124.66  E-value: 7.06e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465210 132 GQGYLRESDLENYILELIPTLPQLDGLEKS--FYSFYVCTAVRKFFFFLDPLRTGKIKIQDILACSFLDDLLELRDEEls 209
Cdd:cd21506    23 NCSYLEQEDFIPLLQDIVDTHPGLTFLKDApeFHSRYITTVIQRIFYTVNRSWSGKITLTELRKSNFLQTLALLEEED-- 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465210 210 KESQETNWFSAPSALRVYGQYLNLDKDHNGMLSKEELSRYGTATMTNVFLDRVFQECLTY------DGEMDYKTYLDFVL 283
Cdd:cd21506   101 DINQITDYFSYEHFYVIYCKFWELDTDHDLYIDQKDLARYNDQASSSRIIERIFSGAVTRgnsvqkEGRMSYADFVWFLI 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465210 284 ALENRKEPAALQYIFKLLDIENKGYLNVFSLNYFFRAIQELMKIHGQDPVSFQDVKDEIFDMVKPKDPLKISLQDLINSN 363
Cdd:cd21506   181 SEEDKRNPTSIEYWFRCMDLDGDGVLSMYELEYFYEEQCERMEAMGIEPLPFHDLLCQMLDLVKPEVDGKITLRDLKRCR 260

                         250       260
                  ....*....|....*....|..
gi 1370465210 364 QGDTVTTILIDLNGFWTYENRE 385
Cdd:cd21506   261 MAHIFYDTFFNLEKYLDHEQRD 282
PPP2R3B cd21507
serine/threonine protein phosphatase 2A regulatory subunit B" subunit beta; Heterotrimeric ...
 125-359 2.28e-28

serine/threonine protein phosphatase 2A regulatory subunit B" subunit beta; Heterotrimeric serine/threonine protein phosphatase 2A (PP2A) consists of scaffolding (A), catalytic (C), and variable (B, B', and B") subunits. The variable subunits dictate subcellular localization and substrate specificity of the PP2A holoenzyme. This group contains protein phosphatase subunit PR70 (also known as protein phosphatase 2 regulatory subunit B'' subunit beta, PR48, NYREN8, PPP2R3L, or PPP2R3LY) that is encoded by the PPP2R3B gene. This substrate-recognizing subunit of PP2A has a two-domain elongated structure with two calcium EF-hands, each displaying different affinities to Ca2+. PPP2R3B/PR70 is a gonosomal melanoma tumor suppressor gene; PR70 decreased melanoma growth by negatively interfering with DNA replication and cell cycle progression through its role in stabilizing the cell division cycle 6 (CDC6)-chromatin licensing and DNA replication factor 1 (CDT1) interaction, which delays the firing of origins of DNA replication.


Pssm-ID: 410340  Cd Length: 355  Bit Score: 114.28  E-value: 2.28e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465210 125 LSLYDVAGQGYLRESDLENYILELIPTLPQLDGLEKS--FYSFYVCTAVRKFFFFLDPLRTGKIKIQDILACSFLDDLLE 202
Cdd:cd21507    90 VHLLMKPGCNYLVQEDFIPFLQDVVNTHPGLSFLKEAseFHSRYITTVIQRIFYTVNRSWSGRITCTELRRSSFLQNVAL 169

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465210 203 LRDEElsKESQETNWFSAPSALRVYGQYLNLDKDHNGMLSKEELSRYGTATMTNVFLDRVFQECLTY------DGEMDYK 276
Cdd:cd21507   170 LEEEA--DINQLTEFFSYEHFYVIYCKFWELDTDHDLYIDQKDLARHNDHAISNRMIERIFSGAVTRgrkaqkEGKISYA 247

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465210 277 TYLDFVLALENRKEPAALQYIFKLLDIENKGYLNVFSLNYFFRAIQELMKIHGQDPVSFQDVKDEIFDMVKPKDPLKISL 356
Cdd:cd21507   248 DFVWFLISEEDKKTPTSIEYWFRCMDLDGDGALSMYELEYFYEEQCQKLDNMAIEPLPFEDCLCQMLDLVKPRTEGKITL 327


                  ...
gi 1370465210 357 QDL 359
Cdd:cd21507   328 HDL 330
EF-hand_13 pfam17958
EF-hand domain; This entry represents an EF-hand domain found in one of the regulatory B ...
 132-206 5.48e-04

EF-hand domain; This entry represents an EF-hand domain found in one of the regulatory B subunits of PP2A.


Pssm-ID: 465586 [Multi-domain]  Cd Length: 90  Bit Score: 38.88  E-value: 5.48e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1370465210 132 GQGYLRESDLENYILELIPTLPQLDGLEKS--FYSFYVCTAVRKFFFFLDPLRTGKIKIQDILACSFLDDLLELRDE 206
Cdd:pfam17958  14 GKNYLSREDFYPFVQDVVDTHPGLEFLREAeeFQDKYIQTVIARIFYVVNRSWSGKITLLELRKSDLLKAVRQLDEE 90
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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