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Conserved domains on  [gi|1371546706|ref|XP_024329086|]
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CCR4-NOT transcription complex subunit 5, putative [Plasmodium falciparum 3D7]

Protein Classification

NOT2/NOT3/NOT5 family protein( domain architecture ID 10514428)

NOT2/NOT3/NOT5 family protein similar to Homo sapiens CCR4-NOT transcription complex subunit 2 (CNOT2), which is a component of the CCR4-NOT complex that is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
NOT2_3_5 pfam04153
NOT2 / NOT3 / NOT5 family; NOT1, NOT2, NOT3, NOT4 and NOT5 form a nuclear complex that ...
67-169 8.23e-26

NOT2 / NOT3 / NOT5 family; NOT1, NOT2, NOT3, NOT4 and NOT5 form a nuclear complex that negatively regulates the basal and activated transcription of many genes. This family includes NOT2, NOT3 and NOT5.


:

Pssm-ID: 461199  Cd Length: 121  Bit Score: 95.36  E-value: 8.23e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371546706  67 NPCKFfPTTPLSVYQSPELFEKLHLDTLFFIFYYQPGTYQQHLAAKELKKKSWKYHKKYTTWLLPDfNTIKILNEQVEHG 146
Cdd:pfam04153  22 NPACY-PQEPLPRLESPEKFSKFDDETLFYIFYSMPGDYAQYLAAKELKKRSWRYHKKLRTWFTRD-EEPKVITNEYERG 99
                          90       100
                  ....*....|....*....|...
gi 1371546706 147 TYVSFDYvsTWSKQLKKNFSFEY 169
Cdd:pfam04153 100 TYIYFDY--TWEQRRKKDFTLDY 120
 
Name Accession Description Interval E-value
NOT2_3_5 pfam04153
NOT2 / NOT3 / NOT5 family; NOT1, NOT2, NOT3, NOT4 and NOT5 form a nuclear complex that ...
67-169 8.23e-26

NOT2 / NOT3 / NOT5 family; NOT1, NOT2, NOT3, NOT4 and NOT5 form a nuclear complex that negatively regulates the basal and activated transcription of many genes. This family includes NOT2, NOT3 and NOT5.


Pssm-ID: 461199  Cd Length: 121  Bit Score: 95.36  E-value: 8.23e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371546706  67 NPCKFfPTTPLSVYQSPELFEKLHLDTLFFIFYYQPGTYQQHLAAKELKKKSWKYHKKYTTWLLPDfNTIKILNEQVEHG 146
Cdd:pfam04153  22 NPACY-PQEPLPRLESPEKFSKFDDETLFYIFYSMPGDYAQYLAAKELKKRSWRYHKKLRTWFTRD-EEPKVITNEYERG 99
                          90       100
                  ....*....|....*....|...
gi 1371546706 147 TYVSFDYvsTWSKQLKKNFSFEY 169
Cdd:pfam04153 100 TYIYFDY--TWEQRRKKDFTLDY 120
CDC36 COG5601
General negative regulator of transcription subunit [Transcription];
89-173 1.48e-06

General negative regulator of transcription subunit [Transcription];


Pssm-ID: 227888  Cd Length: 172  Bit Score: 46.13  E-value: 1.48e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371546706  89 LHLDTLFFIFYYQPGTYQQHLAAKELKKKSWKYHKKYTTWLLPDFNTIKIL-NEQVEHGTYVSFDYVStWSKqLKKNFSF 167
Cdd:COG5601    89 FHDETLFYIFYSFPNDVLQEKAYDELLKRNWRFHKMLKCWLTFNPGMSPATaDHVKERGSYVFFDPFS-WSK-VSLDFLL 166

                  ....*.
gi 1371546706 168 EYIHLE 173
Cdd:COG5601   167 DYKAVR 172
 
Name Accession Description Interval E-value
NOT2_3_5 pfam04153
NOT2 / NOT3 / NOT5 family; NOT1, NOT2, NOT3, NOT4 and NOT5 form a nuclear complex that ...
67-169 8.23e-26

NOT2 / NOT3 / NOT5 family; NOT1, NOT2, NOT3, NOT4 and NOT5 form a nuclear complex that negatively regulates the basal and activated transcription of many genes. This family includes NOT2, NOT3 and NOT5.


Pssm-ID: 461199  Cd Length: 121  Bit Score: 95.36  E-value: 8.23e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371546706  67 NPCKFfPTTPLSVYQSPELFEKLHLDTLFFIFYYQPGTYQQHLAAKELKKKSWKYHKKYTTWLLPDfNTIKILNEQVEHG 146
Cdd:pfam04153  22 NPACY-PQEPLPRLESPEKFSKFDDETLFYIFYSMPGDYAQYLAAKELKKRSWRYHKKLRTWFTRD-EEPKVITNEYERG 99
                          90       100
                  ....*....|....*....|...
gi 1371546706 147 TYVSFDYvsTWSKQLKKNFSFEY 169
Cdd:pfam04153 100 TYIYFDY--TWEQRRKKDFTLDY 120
CDC36 COG5601
General negative regulator of transcription subunit [Transcription];
89-173 1.48e-06

General negative regulator of transcription subunit [Transcription];


Pssm-ID: 227888  Cd Length: 172  Bit Score: 46.13  E-value: 1.48e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371546706  89 LHLDTLFFIFYYQPGTYQQHLAAKELKKKSWKYHKKYTTWLLPDFNTIKIL-NEQVEHGTYVSFDYVStWSKqLKKNFSF 167
Cdd:COG5601    89 FHDETLFYIFYSFPNDVLQEKAYDELLKRNWRFHKMLKCWLTFNPGMSPATaDHVKERGSYVFFDPFS-WSK-VSLDFLL 166

                  ....*.
gi 1371546706 168 EYIHLE 173
Cdd:COG5601   167 DYKAVR 172
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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