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Conserved domains on  [gi|1435549377|ref|XP_025847002|]
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glycine N-acyltransferase-like protein 3 [Vulpes vulpes]

Protein Classification

glycine N-acyltransferase family protein( domain architecture ID 10532672)

glycine N-acyltransferase family protein may transfer an acyl group to the N-terminus of glutamine; similar to mouse glycine N-acyltransferase-like protein 3 (GLYATL3) which catalyzes the conjugation of long-chain fatty acyl-CoA thioester and glycine to produce long-chain N-(fatty acyl)glycine, in the primary fatty acid amide biosynthetic pathway

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Gly_acyl_tr_N pfam06021
Aralkyl acyl-CoA:amino acid N-acyltransferase; This family consists of several mammalian ...
 1-190 1.36e-113

Aralkyl acyl-CoA:amino acid N-acyltransferase; This family consists of several mammalian specific aralkyl acyl-CoA:amino acid N-acyltransferase (glycine N-acyltransferase) proteins EC:2.3.1.13.


:

Pssm-ID: 461802  Cd Length: 203  Bit Score: 325.68  E-value: 1.36e-113
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435549377   1 MQVLNCSTKLLILEKMLKSHFPESLKVYGAVMNINRGNPFQKEVVVDSWPDFKAVITRRQKEAETDNLDHYTNAYAVFYK 80
Cdd:pfam06021   1 MLVLQCPQKLQTLEKSLRKSLPESLKVYGAVFHINRGNPFNLEVLVDSWPDFQTVITRPQKEEMTDDLDHYTNTYAIFYK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435549377  81 DVRAYQQLLEERDVINWDQVFQIQGLQSELYDVSKAVANSKQLGVKLTSFKAVHFSPHSTLPDTSSL------------- 147
Cdd:pfam06021  81 DPDALQELLESPDVINWKQHFQIQGCQSSLDEVIQEVAASKSVQVKYTKYILYMTPDPAKLLTPSLLdaknlspsgkpka 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1435549377 148 MSSPPRLTYLSVTDADLLNRTWSRGGNEQCLQYIKNLISCFPS 190
Cdd:pfam06021 161 NQEMFKLSSLDVSHAALVNETWSFGGNERSLRYIERCIQNFPS 203
NAT_SF super family cl17182
N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of ...
 191-279 7.65e-15

N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase which catalyze the transfer of an acetyl group to a substrate. The mechanism is an ordered Bi-Bi ternary complex kinetic mechanism for most GNATs: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and then CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/ph enylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


The actual alignment was detected with superfamily member pfam08444:

Pssm-ID: 473072  Cd Length: 89  Bit Score: 68.24  E-value: 7.65e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435549377 191 VCVRDDKGNPVSWSLTDQFATMCHGYTLPEYRRKGYSRLVALTLARKLQSRGFPSQGNVLDDNLASISLLKSVHAEFLPC 270
Cdd:pfam08444   1 FCLLGPEGTPVSWSLMDQTGELRMAGTLPKYRRQGLMSHVIYHQAQYLEKLGFPVYSHVDKANEISQKMSGNLGHVPMPC 80


                  ....*....
gi 1435549377 271 RFHRLILTP 279
Cdd:pfam08444  81 GWNQWNCVP 89
 
Name Accession Description Interval E-value
Gly_acyl_tr_N pfam06021
Aralkyl acyl-CoA:amino acid N-acyltransferase; This family consists of several mammalian ...
 1-190 1.36e-113

Aralkyl acyl-CoA:amino acid N-acyltransferase; This family consists of several mammalian specific aralkyl acyl-CoA:amino acid N-acyltransferase (glycine N-acyltransferase) proteins EC:2.3.1.13.


Pssm-ID: 461802  Cd Length: 203  Bit Score: 325.68  E-value: 1.36e-113
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435549377   1 MQVLNCSTKLLILEKMLKSHFPESLKVYGAVMNINRGNPFQKEVVVDSWPDFKAVITRRQKEAETDNLDHYTNAYAVFYK 80
Cdd:pfam06021   1 MLVLQCPQKLQTLEKSLRKSLPESLKVYGAVFHINRGNPFNLEVLVDSWPDFQTVITRPQKEEMTDDLDHYTNTYAIFYK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435549377  81 DVRAYQQLLEERDVINWDQVFQIQGLQSELYDVSKAVANSKQLGVKLTSFKAVHFSPHSTLPDTSSL------------- 147
Cdd:pfam06021  81 DPDALQELLESPDVINWKQHFQIQGCQSSLDEVIQEVAASKSVQVKYTKYILYMTPDPAKLLTPSLLdaknlspsgkpka 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1435549377 148 MSSPPRLTYLSVTDADLLNRTWSRGGNEQCLQYIKNLISCFPS 190
Cdd:pfam06021 161 NQEMFKLSSLDVSHAALVNETWSFGGNERSLRYIERCIQNFPS 203
Gly_acyl_tr_C pfam08444
Aralkyl acyl-CoA:amino acid N-acyltransferase, C-terminal region; This family features the ...
 191-279 7.65e-15

Aralkyl acyl-CoA:amino acid N-acyltransferase, C-terminal region; This family features the C-terminal region of several mammalian specific aralkyl acyl-CoA:amino acid N-acyltransferase (glycine N-acyltransferase) proteins EC:2.3.1.13.


Pssm-ID: 117021  Cd Length: 89  Bit Score: 68.24  E-value: 7.65e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435549377 191 VCVRDDKGNPVSWSLTDQFATMCHGYTLPEYRRKGYSRLVALTLARKLQSRGFPSQGNVLDDNLASISLLKSVHAEFLPC 270
Cdd:pfam08444   1 FCLLGPEGTPVSWSLMDQTGELRMAGTLPKYRRQGLMSHVIYHQAQYLEKLGFPVYSHVDKANEISQKMSGNLGHVPMPC 80


                  ....*....
gi 1435549377 271 RFHRLILTP 279
Cdd:pfam08444  81 GWNQWNCVP 89
COG3393 COG3393
Predicted acetyltransferase, GNAT family [General function prediction only];
216-259 4.07e-05

Predicted acetyltransferase, GNAT family [General function prediction only];


Pssm-ID: 442620 [Multi-domain]  Cd Length: 86  Bit Score: 41.43  E-value: 4.07e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1435549377 216 YTLPEYRRKGYSRLVALTLARKLQSRGFPS-QGNVLDDNLASISL 259
Cdd:COG3393    22 YTHPEYRGRGLASALVAALAREALARGARTpFLYVDADNPAARRL 66
 
Name Accession Description Interval E-value
Gly_acyl_tr_N pfam06021
Aralkyl acyl-CoA:amino acid N-acyltransferase; This family consists of several mammalian ...
 1-190 1.36e-113

Aralkyl acyl-CoA:amino acid N-acyltransferase; This family consists of several mammalian specific aralkyl acyl-CoA:amino acid N-acyltransferase (glycine N-acyltransferase) proteins EC:2.3.1.13.


Pssm-ID: 461802  Cd Length: 203  Bit Score: 325.68  E-value: 1.36e-113
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435549377   1 MQVLNCSTKLLILEKMLKSHFPESLKVYGAVMNINRGNPFQKEVVVDSWPDFKAVITRRQKEAETDNLDHYTNAYAVFYK 80
Cdd:pfam06021   1 MLVLQCPQKLQTLEKSLRKSLPESLKVYGAVFHINRGNPFNLEVLVDSWPDFQTVITRPQKEEMTDDLDHYTNTYAIFYK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435549377  81 DVRAYQQLLEERDVINWDQVFQIQGLQSELYDVSKAVANSKQLGVKLTSFKAVHFSPHSTLPDTSSL------------- 147
Cdd:pfam06021  81 DPDALQELLESPDVINWKQHFQIQGCQSSLDEVIQEVAASKSVQVKYTKYILYMTPDPAKLLTPSLLdaknlspsgkpka 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1435549377 148 MSSPPRLTYLSVTDADLLNRTWSRGGNEQCLQYIKNLISCFPS 190
Cdd:pfam06021 161 NQEMFKLSSLDVSHAALVNETWSFGGNERSLRYIERCIQNFPS 203
Gly_acyl_tr_C pfam08444
Aralkyl acyl-CoA:amino acid N-acyltransferase, C-terminal region; This family features the ...
 191-279 7.65e-15

Aralkyl acyl-CoA:amino acid N-acyltransferase, C-terminal region; This family features the C-terminal region of several mammalian specific aralkyl acyl-CoA:amino acid N-acyltransferase (glycine N-acyltransferase) proteins EC:2.3.1.13.


Pssm-ID: 117021  Cd Length: 89  Bit Score: 68.24  E-value: 7.65e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435549377 191 VCVRDDKGNPVSWSLTDQFATMCHGYTLPEYRRKGYSRLVALTLARKLQSRGFPSQGNVLDDNLASISLLKSVHAEFLPC 270
Cdd:pfam08444   1 FCLLGPEGTPVSWSLMDQTGELRMAGTLPKYRRQGLMSHVIYHQAQYLEKLGFPVYSHVDKANEISQKMSGNLGHVPMPC 80


                  ....*....
gi 1435549377 271 RFHRLILTP 279
Cdd:pfam08444  81 GWNQWNCVP 89
FR47 pfam08445
FR47-like protein; The members of this family are similar to the C-terminal region of the D. ...
 193-263 2.99e-06

FR47-like protein; The members of this family are similar to the C-terminal region of the D. melanogaster hypothetical protein FR47. This protein has been found to consist of two N-acyltransferase-like domains swapped with the C-terminal strands.


Pssm-ID: 117022 [Multi-domain]  Cd Length: 86  Bit Score: 44.63  E-value: 2.99e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1435549377 193 VRDDKGNPVSWSLTDQFATMCHGYTLPEYRRKGYSRLVALTLARKLQSRGFPSQGNVLDDNLASISLLKSV 263
Cdd:pfam08445   5 YRGDTGELAAWCLRLPGGELGALQTLPEHRRRGLGSRLVAALARGIAERGITPFAVVVAGNTPSRRLYEKL 75
COG3393 COG3393
Predicted acetyltransferase, GNAT family [General function prediction only];
216-259 4.07e-05

Predicted acetyltransferase, GNAT family [General function prediction only];


Pssm-ID: 442620 [Multi-domain]  Cd Length: 86  Bit Score: 41.43  E-value: 4.07e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1435549377 216 YTLPEYRRKGYSRLVALTLARKLQSRGFPS-QGNVLDDNLASISL 259
Cdd:COG3393    22 YTHPEYRGRGLASALVAALAREALARGARTpFLYVDADNPAARRL 66
MnaT COG1247
L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];
216-262 1.22e-03

L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];


Pssm-ID: 440860 [Multi-domain]  Cd Length: 163  Bit Score: 38.82  E-value: 1.22e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1435549377 216 YTLPEYRRKGY-SRLVAlTLARKLQSRGFPS-QGNVLDDNLASISLLKS 262
Cdd:COG1247    87 YVDPDARGRGIgRALLE-ALIERARARGYRRlVAVVLADNEASIALYEK 134
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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