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Conserved domains on  [gi|1469164934|ref|XP_026089121|]
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ankyrin repeat and SOCS box protein 2-like isoform X2 [Carassius auratus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
155-403 8.32e-42

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 153.19  E-value: 8.32e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469164934 155 LKILLKAKPETINKQTNKSQTPLMLAVCRKHFSCVEHLLEQGADPNLANNQWETPLYKACEKANEAIVELLLRFGASPTK 234
Cdd:COG0666    36 LLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNA 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469164934 235 ACAQGGTPLHEAVRNKKLKITKMLIKAGAKLCAKNIYGIDSLFMAAQCNSVEVLNYLIYKGGNVNTQANDDASALFEACK 314
Cdd:COG0666   116 RDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAE 195

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469164934 315 NGHAKAVEILLSQSADVNITNKTGLLPIHVAAKNGHDSIVAMLIPRTSMVKVR-SSGISSLHFAAENNKDSVLEILIDAG 393
Cdd:COG0666   196 NGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKdKDGLTALLLAAAAGAALIVKLLLLAL 275

                         250
                  ....*....|
gi 1469164934 394 YDVNAKMSDD 403
Cdd:COG0666   276 LLLAAALLDL 285
SOCS_ASB_like cd03716
SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB ...
 599-638 2.30e-15

SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB (SPRY domain-containing SOCS box proteins) protein families. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence of a variable number of repeats. SSB proteins contain a central SPRY domain and a C-terminal SOCS. Recently, it has been shown that all four SSB proteins interact with the MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF), and that SSB-1, SSB-2, and SSB-4 interact with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain.


:

Pssm-ID: 239686  Cd Length: 42  Bit Score: 70.22  E-value: 2.30e-15
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1469164934 599 PCTLMHLCRLKIRQRLGIQRLCHISALPLPERLIMFLNYE 638
Cdd:cd03716     3 PRSLQHLCRLAIRRCLGRRRLELIKKLPLPPRLKDYLLYE 42
Ank_2 pfam12796
Ankyrin repeats (3 copies);
374-471 1.90e-12

Ankyrin repeats (3 copies);


:

Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 63.60  E-value: 1.90e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469164934 374 LHFAAENNKDSVLEILIDAGYDVNAKMSDDWskmyedhrsTALYSAVANSNIEAATMLLE-AGADPNLDIFNPLLVAVRI 452
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGR---------TALHLAAKNGHLEIVKLLLEhADVNLKDNGRTALHYAARS 71

                          90
                  ....*....|....*....
gi 1469164934 453 GSMEMVALLLKHGANVNAM 471
Cdd:pfam12796  72 GHLEIVKLLLEKGADINVK 90
Ank_4 pfam13637
Ankyrin repeats (many copies);
106-159 2.66e-04

Ankyrin repeats (many copies);


:

Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 39.18  E-value: 2.66e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1469164934 106 LDPILSAIWKGDVKALqKIIHSKSKNLYEPNKDGWLPLHESAYYGSVKCLKILL 159
Cdd:pfam13637   2 LTALHAAAASGHLELL-RLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
155-403 8.32e-42

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 153.19  E-value: 8.32e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469164934 155 LKILLKAKPETINKQTNKSQTPLMLAVCRKHFSCVEHLLEQGADPNLANNQWETPLYKACEKANEAIVELLLRFGASPTK 234
Cdd:COG0666    36 LLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNA 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469164934 235 ACAQGGTPLHEAVRNKKLKITKMLIKAGAKLCAKNIYGIDSLFMAAQCNSVEVLNYLIYKGGNVNTQANDDASALFEACK 314
Cdd:COG0666   116 RDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAE 195

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469164934 315 NGHAKAVEILLSQSADVNITNKTGLLPIHVAAKNGHDSIVAMLIPRTSMVKVR-SSGISSLHFAAENNKDSVLEILIDAG 393
Cdd:COG0666   196 NGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKdKDGLTALLLAAAAGAALIVKLLLLAL 275

                         250
                  ....*....|
gi 1469164934 394 YDVNAKMSDD 403
Cdd:COG0666   276 LLLAAALLDL 285
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 118-409 5.73e-22

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 98.97  E-value: 5.73e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469164934 118 VKALQKIIHSKSKNLYEpNKDGWLPLHESAYYGSVKCLKILLKaKPETINKQTNKSQTPLMLAVCRKH-----FSCVEHL 192
Cdd:PHA03100   15 VKNIKYIIMEDDLNDYS-YKKPVLPLYLAKEARNIDVVKILLD-NGADINSSTKNNSTPLHYLSNIKYnltdvKEIVKLL 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469164934 193 LEQGADPNLANNQWETPL-YKACEKANEA-IVELLLRFGASPTKACAQGGTPLHEAVRNK--KLKITKMLIKAGAKLCAK 268
Cdd:PHA03100   93 LEYGANVNAPDNNGITPLlYAISKKSNSYsIVEYLLDNGANVNIKNSDGENLLHLYLESNkiDLKILKLLIDKGVDINAK 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469164934 269 NiygidslfmaaqcnsveVLNYLIYKGGNVNTQANDDASALFEACKNGHAKAVEILLSQSADVNITNKTGLLPIHVAAKN 348
Cdd:PHA03100  173 N-----------------RVNYLLSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILN 235

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1469164934 349 GHDSIVAMLIPRTSMVKVRSSGISSLHFAAENNKDS--------VLEILIDAGYDVNAKMSDDWSKMYE 409
Cdd:PHA03100  236 NNKEIFKLLLNNGPSIKTIIETLLYFKDKDLNTITKikmlkksiMYMFLLDPGFYKNRKLIENSKSLKD 304
Ank_2 pfam12796
Ankyrin repeats (3 copies);
309-399 2.20e-17

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 77.46  E-value: 2.20e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469164934 309 LFEACKNGHAKAVEILLSQSADVNITNKTGLLPIHVAAKNGHDSIVAMLIPRtSMVKVRSSGISSLHFAAENNKDSVLEI 388
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKDNGRTALHYAARSGHLEIVKL 79

                          90
                  ....*....|.
gi 1469164934 389 LIDAGYDVNAK 399
Cdd:pfam12796  80 LLEKGADINVK 90
SOCS_ASB_like cd03716
SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB ...
 599-638 2.30e-15

SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB (SPRY domain-containing SOCS box proteins) protein families. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence of a variable number of repeats. SSB proteins contain a central SPRY domain and a C-terminal SOCS. Recently, it has been shown that all four SSB proteins interact with the MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF), and that SSB-1, SSB-2, and SSB-4 interact with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain.


Pssm-ID: 239686  Cd Length: 42  Bit Score: 70.22  E-value: 2.30e-15
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1469164934 599 PCTLMHLCRLKIRQRLGIQRLCHISALPLPERLIMFLNYE 638
Cdd:cd03716     3 PRSLQHLCRLAIRRCLGRRRLELIKKLPLPPRLKDYLLYE 42
Ank_2 pfam12796
Ankyrin repeats (3 copies);
374-471 1.90e-12

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 63.60  E-value: 1.90e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469164934 374 LHFAAENNKDSVLEILIDAGYDVNAKMSDDWskmyedhrsTALYSAVANSNIEAATMLLE-AGADPNLDIFNPLLVAVRI 452
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGR---------TALHLAAKNGHLEIVKLLLEhADVNLKDNGRTALHYAARS 71

                          90
                  ....*....|....*....
gi 1469164934 453 GSMEMVALLLKHGANVNAM 471
Cdd:pfam12796  72 GHLEIVKLLLEKGADINVK 90
SOCS_box pfam07525
SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more ...
 599-635 3.64e-12

SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.


Pssm-ID: 462192  Cd Length: 39  Bit Score: 61.03  E-value: 3.64e-12
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1469164934 599 PCTLMHLCRLKIRQRLGIQRLCHISALPLPERLIMFL 635
Cdd:pfam07525   2 PRSLQHLCRLAIRRALGKRRLGAIDKLPLPPLLKDYL 38
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 108-244 5.56e-12

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 68.89  E-value: 5.56e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469164934 108 PILSAIWKGDVKALQKIIHSKSKNLYEPNKDGWLPLHESAYYGSVKCLKILLKAKPETINK----QTNKSQTPLMLAVCR 183
Cdd:cd22192    20 PLLLAAKENDVQAIKKLLKCPSCDLFQRGALGETALHVAALYDNLEAAVVLMEAAPELVNEpmtsDLYQGETALHIAVVN 99

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1469164934 184 KHFSCVEHLLEQGAD------------PNLANNQW--ETPL-YKACEkANEAIVELLLRFGASPTKACAQGGTPLH 244
Cdd:cd22192   100 QNLNLVRELIARGADvvspratgtffrPGPKNLIYygEHPLsFAACV-GNEEIVRLLIEHGADIRAQDSLGNTVLH 174
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 371-502 2.91e-11

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 65.84  E-value: 2.91e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469164934 371 ISSLHFAAENNKDSVLEILIDAGYDVNAKMSDDWSKMYedhrSTALYSAVANSNIEAATMLLEAGADPNLDIFN---PLL 447
Cdd:PHA03100   36 VLPLYLAKEARNIDVVKILLDNGADINSSTKNNSTPLH----YLSNIKYNLTDVKEIVKLLLEYGANVNAPDNNgitPLL 111

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1469164934 448 VAV--RIGSMEMVALLLKHGANVNAMLPTHPTSFPAALVFCLRFMLMMKCLLDNGCD 502
Cdd:PHA03100  112 YAIskKSNSYSIVEYLLDNGANVNIKNSDGENLLHLYLESNKIDLKILKLLIDKGVD 168
SOCS_box smart00969
The SOCS box acts as a bridge between specific substrate- binding domains and more generic ...
 600-638 1.40e-07

The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases;


Pssm-ID: 198037  Cd Length: 34  Bit Score: 47.79  E-value: 1.40e-07
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1469164934  600 CTLMHLCRLKIRQRLGiqrlcHISALPLPERLIMFLNYE 638
Cdd:smart00969   1 RSLQHLCRLAIRRSLG-----GIDKLPLPPRLKDYLLYY 34
TRPV cd21882
Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily ...
 368-474 3.12e-05

Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily (TRPV), named after the vanilloid receptor 1 (TRPV1), consists of six members: four thermo-sensing channels (TRPV1, TRPV2, TRPV3, and TRPV4) and two Ca2+ selective channels (TRPV5 and TRPV6). The calcium-selective channels TRPV5 and TRPV6 can be heterotetramers and are important for general Ca2+ homeostasis. All four channels within the TRPV1-4 group show temperature-invoked currents when expressed in heterologous cell systems, ranging from activation at ~25C for TRPV4 to ~52C for TRPV2. The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains. The TRP family consists of membrane proteins that function as ion channels that communicate between the cell and its environment, by a vast array of physical or chemical stimuli, including radiation (in the form of temperature, infrared ,or light) and pressure (osmotic or mechanical). TRP channels are formed by a tetrameric complex of channel subunits. Based on sequence identity, the mammalian TRP channel family is classified into six subfamilies, with significant sequence similarity within the transmembrane domains, but very low similarity in their N- and C-terminal cytoplasmic regions. The six subfamilies are named based on their first member: TRPC (canonical), TRPV (vanilloid), TRPM (melastatin), TRPA (ankyrin), TRPML (mucolipin), and TRPP (polycystic).


Pssm-ID: 411975 [Multi-domain]  Cd Length: 600  Bit Score: 47.18  E-value: 3.12e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469164934 368 SSGISSLHFAAENNKDSVLE---ILIDAGYD-------VNAKMSDDWskmYEDHrsTALYSAVANSNIEAATMLLEAGAD 437
Cdd:cd21882    24 ATGKTCLHKAALNLNDGVNEaimLLLEAAPDsgnpkelVNAPCTDEF---YQGQ--TALHIAIENRNLNLVRLLVENGAD 98

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1469164934 438 PNL----DIFN------------PLLVAVRIGSMEMVALLLKHGANVNAMLPT 474
Cdd:cd21882    99 VSAratgRFFRkspgnlfyfgelPLSLAACTNQEEIVRLLLENGAQPAALEAQ 151
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 282-470 1.90e-04

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 44.69  E-value: 1.90e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469164934 282 CNSVEVLNY-LIYKGG----NVNTQAND--DASALFEACK-NGHAKAVEILLSQSADVnitnKTGLLPIHVAAKNGHDSI 353
Cdd:TIGR00870  22 LPAAERGDLaSVYRDLeepkKLNINCPDrlGRSALFVAAIeNENLELTELLLNLSCRG----AVGDTLLHAISLEYVDAV 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469164934 354 VAMLIPR---------TSMVKVRSS-----GISSLHFAAENNKDSVLEILIDAGYDVNAKMSDDWSkMYEDHRSTALYSA 419
Cdd:TIGR00870  98 EAILLHLlaafrksgpLELANDQYTseftpGITALHLAAHRQNYEIVKLLLERGASVPARACGDFF-VKSQGVDSFYHGE 176

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1469164934 420 vansnieaatmlleagadpnldifNPLLVAVRIGSMEMVALLLKHGANVNA 470
Cdd:TIGR00870 177 ------------------------SPLNAAACLGSPSIVALLSEDPADILT 203
Ank_4 pfam13637
Ankyrin repeats (many copies);
106-159 2.66e-04

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 39.18  E-value: 2.66e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1469164934 106 LDPILSAIWKGDVKALqKIIHSKSKNLYEPNKDGWLPLHESAYYGSVKCLKILL 159
Cdd:pfam13637   2 LTALHAAAASGHLELL-RLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 175-201 1.59e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 36.41  E-value: 1.59e-03
                           10        20
                   ....*....|....*....|....*..
gi 1469164934  175 TPLMLAVCRKHFSCVEHLLEQGADPNL 201
Cdd:smart00248   4 TPLHLAAENGNLEVVKLLLDKGADINA 30
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 443-470 7.83e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 34.49  E-value: 7.83e-03
                           10        20
                   ....*....|....*....|....*...
gi 1469164934  443 FNPLLVAVRIGSMEMVALLLKHGANVNA 470
Cdd:smart00248   3 RTPLHLAAENGNLEVVKLLLDKGADINA 30
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
155-403 8.32e-42

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 153.19  E-value: 8.32e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469164934 155 LKILLKAKPETINKQTNKSQTPLMLAVCRKHFSCVEHLLEQGADPNLANNQWETPLYKACEKANEAIVELLLRFGASPTK 234
Cdd:COG0666    36 LLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNA 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469164934 235 ACAQGGTPLHEAVRNKKLKITKMLIKAGAKLCAKNIYGIDSLFMAAQCNSVEVLNYLIYKGGNVNTQANDDASALFEACK 314
Cdd:COG0666   116 RDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAE 195

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469164934 315 NGHAKAVEILLSQSADVNITNKTGLLPIHVAAKNGHDSIVAMLIPRTSMVKVR-SSGISSLHFAAENNKDSVLEILIDAG 393
Cdd:COG0666   196 NGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKdKDGLTALLLAAAAGAALIVKLLLLAL 275

                         250
                  ....*....|
gi 1469164934 394 YDVNAKMSDD 403
Cdd:COG0666   276 LLLAAALLDL 285
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
104-358 9.87e-42

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 153.19  E-value: 9.87e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469164934 104 NDLDPILSAIWKGDVKALQKIIHSKSKNLYEPNKDGWLPLHESAYYGSVKCLKILLKAKPEtINKQTNKSQTPLMLAVCR 183
Cdd:COG0666    19 LLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGAD-INAKDDGGNTLLHAAARN 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469164934 184 KHFSCVEHLLEQGADPNLANNQWETPLYKACEKANEAIVELLLRFGASPTKACAQGGTPLHEAVRNKKLKITKMLIKAGA 263
Cdd:COG0666    98 GDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGA 177

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469164934 264 KLCAKNIYGIDSLFMAAQCNSVEVLNYLIYKGGNVNTQANDDASALFEACKNGHAKAVEILLSQSADVNITNKTGLLPIH 343
Cdd:COG0666   178 DVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALL 257

                         250
                  ....*....|....*
gi 1469164934 344 VAAKNGHDSIVAMLI 358
Cdd:COG0666   258 LAAAAGAALIVKLLL 272
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
104-342 2.38e-41

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 152.03  E-value: 2.38e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469164934 104 NDLDPILSAIWKGDVKALQKIIHSKSKNLYEPNKDGWLPLHESAYYGSVKCLKILLKAKPEtINKQTNKSQTPLMLAVCR 183
Cdd:COG0666    52 ALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGAD-VNARDKDGETPLHLAAYN 130

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469164934 184 KHFSCVEHLLEQGADPNLANNQWETPLYKACEKANEAIVELLLRFGASPTKACAQGGTPLHEAVRNKKLKITKMLIKAGA 263
Cdd:COG0666   131 GNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGA 210

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1469164934 264 KLCAKNIYGIDSLFMAAQCNSVEVLNYLIYKGGNVNTQANDDASALFEACKNGHAKAVEILLSQSADVNITNKTGLLPI 342
Cdd:COG0666   211 DVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
155-444 2.36e-38

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 143.56  E-value: 2.36e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469164934 155 LKILLKAKPETINKQTNKSQTPLMLAVCRKHFSCVEHLLEQGADPNLANNQWETPLYKACEKANEAIVELLLRFGASPTK 234
Cdd:COG0666     3 LLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINA 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469164934 235 ACAQGGTPLHEAVRNKKLKITKMLIKAGAKLCAKNIYGIDSLFMAAQCNSVEVLNYLIYKGGNVNTQANDDASALFEACK 314
Cdd:COG0666    83 KDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAA 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469164934 315 NGHAKAVEILLSQSADVNITNKTGLLPIHVAAKNGHDSIVAMLIPRTSMVKVR-SSGISSLHFAAENNKDSVLEILIDAG 393
Cdd:COG0666   163 NGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKdNDGKTALDLAAENGNLEIVKLLLEAG 242

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1469164934 394 YDVNAKMSDDWskmyedhrsTALYSAVANSNIEAATMLLEAGADPNLDIFN 444
Cdd:COG0666   243 ADLNAKDKDGL---------TALLLAAAAGAALIVKLLLLALLLLAAALLD 284
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
189-483 5.87e-37

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 139.70  E-value: 5.87e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469164934 189 VEHLLEQGADPNLANNQWETPLYKACEKANEAIVELLLRFGASPTKACAQGGTPLHEAVRNKKLKITKMLIKAGAKLCAK 268
Cdd:COG0666     4 LLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAK 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469164934 269 NIYGIDSLFMAAQCNSVEVLNYLIYKGGNVNTQANDDASALFEACKNGHAKAVEILLSQSADVNITNKTGLLPIHVAAKN 348
Cdd:COG0666    84 DDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAAN 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469164934 349 GHDSIVamliprtsmvkvrssgisslhfaaennkdsvlEILIDAGYDVNAKMSDDWskmyedhrsTALYSAVANSNIEAA 428
Cdd:COG0666   164 GNLEIV--------------------------------KLLLEAGADVNARDNDGE---------TPLHLAAENGHLEIV 202

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1469164934 429 TMLLEAGADPNL---DIFNPLLVAVRIGSMEMVALLLKHGANVNAMLPTHPTSFPAAL 483
Cdd:COG0666   203 KLLLEAGADVNAkdnDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAA 260
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
252-470 5.25e-30

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 120.06  E-value: 5.25e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469164934 252 LKITKMLIKAGAKLCAKNIYGIDSLFMAAQCNSVEVLNYLIYKGGNVNTQANDDASALFEACKNGHAKAVEILLSQSADV 331
Cdd:COG0666     1 LLLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469164934 332 NITNKTGLLPIHVAAKNGHDSIVAMLIPRTSMVKVR-SSGISSLHFAAENNKDSVLEILIDAGYDVNAKMSDDWskmyed 410
Cdd:COG0666    81 NAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARdKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGN------ 154

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1469164934 411 hrsTALYSAVANSNIEAATMLLEAGADPNL---DIFNPLLVAVRIGSMEMVALLLKHGANVNA 470
Cdd:COG0666   155 ---TPLHLAAANGNLEIVKLLLEAGADVNArdnDGETPLHLAAENGHLEIVKLLLEAGADVNA 214
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 118-409 5.73e-22

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 98.97  E-value: 5.73e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469164934 118 VKALQKIIHSKSKNLYEpNKDGWLPLHESAYYGSVKCLKILLKaKPETINKQTNKSQTPLMLAVCRKH-----FSCVEHL 192
Cdd:PHA03100   15 VKNIKYIIMEDDLNDYS-YKKPVLPLYLAKEARNIDVVKILLD-NGADINSSTKNNSTPLHYLSNIKYnltdvKEIVKLL 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469164934 193 LEQGADPNLANNQWETPL-YKACEKANEA-IVELLLRFGASPTKACAQGGTPLHEAVRNK--KLKITKMLIKAGAKLCAK 268
Cdd:PHA03100   93 LEYGANVNAPDNNGITPLlYAISKKSNSYsIVEYLLDNGANVNIKNSDGENLLHLYLESNkiDLKILKLLIDKGVDINAK 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469164934 269 NiygidslfmaaqcnsveVLNYLIYKGGNVNTQANDDASALFEACKNGHAKAVEILLSQSADVNITNKTGLLPIHVAAKN 348
Cdd:PHA03100  173 N-----------------RVNYLLSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILN 235

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1469164934 349 GHDSIVAMLIPRTSMVKVRSSGISSLHFAAENNKDS--------VLEILIDAGYDVNAKMSDDWSKMYE 409
Cdd:PHA03100  236 NNKEIFKLLLNNGPSIKTIIETLLYFKDKDLNTITKikmlkksiMYMFLLDPGFYKNRKLIENSKSLKD 304
PHA03095 PHA03095
ankyrin-like protein; Provisional
 189-466 1.46e-21

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 98.17  E-value: 1.46e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469164934 189 VEHLLEQGADPNLANNQWETPL-YKACEKANEAIVELLLRFGASPTKACAQGGTPLHEAVRNK--KLKITKMLIKAGAKL 265
Cdd:PHA03095   66 VRLLLEAGADVNAPERCGFTPLhLYLYNATTLDVIKLLIKAGADVNAKDKVGRTPLHVYLSGFniNPKVIRLLLRKGADV 145

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469164934 266 CAKNIYGIDSL--FMAAQCNSVEVLNYLIYKGGNVNTQANDDASALFEACKNGHAKA--VEILLSQSADVNITNKTGLLP 341
Cdd:PHA03095  146 NALDLYGMTPLavLLKSRNANVELLRLLIDAGADVYAVDDRFRSLLHHHLQSFKPRAriVRELIRAGCDPAATDMLGNTP 225

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469164934 342 IHVAAKNG--HDSIVAMLIPRTSMVKVR-SSGISSLHFAAENNKDSVLEILIDAGYDVNAKMSDDwskmyedhrSTALYS 418
Cdd:PHA03095  226 LHSMATGSscKRSLVLPLLIAGISINARnRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDG---------NTPLSL 296

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1469164934 419 AVANSNIEAATMLLEAGADPN-----LDIFNPLLVAVRI-GSMEMVALLLKHGA 466
Cdd:PHA03095  297 MVRNNNGRAVRAALAKNPSAEtvaatLNTASVAGGDIPSdATRLCVAKVVLRGA 350
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 241-474 2.59e-20

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 93.96  E-value: 2.59e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469164934 241 TPLHEAVRNKKLKITKMLIKAGAKL--CAKNIYG---IDSLFMAAQCNSVEVLNYLIYKGGNVNTQANDDASALFEA--C 313
Cdd:PHA03100   37 LPLYLAKEARNIDVVKILLDNGADInsSTKNNSTplhYLSNIKYNLTDVKEIVKLLLEYGANVNAPDNNGITPLLYAisK 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469164934 314 KNGHAKAVEILLSQSADVNITNKTGLLPIHVAAKNGHD--SIVAMLIPRTsmVKVrssgisslhfaaeNNKDSVlEILID 391
Cdd:PHA03100  117 KSNSYSIVEYLLDNGANVNIKNSDGENLLHLYLESNKIdlKILKLLIDKG--VDI-------------NAKNRV-NYLLS 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469164934 392 AGYDVNAKmsddwskmyeDHR-STALYSAVANSNIEAATMLLEAGADPNL-DIFN--PLLVAVRIGSMEMVALLLKHGAN 467
Cdd:PHA03100  181 YGVPINIK----------DVYgFTPLHYAVYNNNPEFVKYLLDLGANPNLvNKYGdtPLHIAILNNNKEIFKLLLNNGPS 250


                  ....*..
gi 1469164934 468 VNAMLPT 474
Cdd:PHA03100  251 IKTIIET 257
Ank_2 pfam12796
Ankyrin repeats (3 copies);
309-399 2.20e-17

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 77.46  E-value: 2.20e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469164934 309 LFEACKNGHAKAVEILLSQSADVNITNKTGLLPIHVAAKNGHDSIVAMLIPRtSMVKVRSSGISSLHFAAENNKDSVLEI 388
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKDNGRTALHYAARSGHLEIVKL 79

                          90
                  ....*....|.
gi 1469164934 389 LIDAGYDVNAK 399
Cdd:pfam12796  80 LLEKGADINVK 90
Ank_2 pfam12796
Ankyrin repeats (3 copies);
177-269 3.13e-17

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 77.08  E-value: 3.13e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469164934 177 LMLAVCRKHFSCVEHLLEQGADPNLANNQWETPLYKACEKANEAIVELLLRFGASptKACAQGGTPLHEAVRNKKLKITK 256
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADV--NLKDNGRTALHYAARSGHLEIVK 78

                          90
                  ....*....|...
gi 1469164934 257 MLIKAGAKLCAKN 269
Cdd:pfam12796  79 LLLEKGADINVKD 91
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 142-468 5.90e-17

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 84.73  E-value: 5.90e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469164934 142 PLHESAYYGSVKCLKILLKAKPEtINKQTNKSQTPLMLAVCRKHFSCVEHLLEqgadpNLAN-NQWETPLYKACEKANEA 220
Cdd:PHA02876  181 PIHYAAERGNAKMVNLLLSYGAD-VNIIALDDLSVLECAVDSKNIDTIKAIID-----NRSNiNKNDLSLLKAIRNEDLE 254

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469164934 221 IVELLLRFGASPTKACAQGGTPLHEAVRNKKL-KITKMLIKAGAKLCAKNIYGIDSLF-MAAQCNSVEVLNYLIYKGGNV 298
Cdd:PHA02876  255 TSLLLYDAGFSVNSIDDCKNTPLHHASQAPSLsRLVPKLLERGADVNAKNIKGETPLYlMAKNGYDTENIRTLIMLGADV 334

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469164934 299 NTQANDDASALFEACKNGHAKAVEI-LLSQSADVNITNKTGLLPIHVAAKNGHDSIVAMLIPRTSMVKVRSSGI-SSLHF 376
Cdd:PHA02876  335 NAADRLYITPLHQASTLDRNKDIVItLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGADIEALSQKIgTALHF 414

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469164934 377 A-AENNKDSVLEILIDAGYDVNAKMSDdwskmyedhRSTAL-YSAVANSNIEAATMLLEAGADPN-LDIFN--PLLVAvr 451
Cdd:PHA02876  415 AlCGTNPYMSVKTLIDRGANVNSKNKD---------LSTPLhYACKKNCKLDVIEMLLDNGADVNaINIQNqyPLLIA-- 483

                         330
                  ....*....|....*..
gi 1469164934 452 IGSMEMVALLLKHGANV 468
Cdd:PHA02876  484 LEYHGIVNILLHYGAEL 500
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 113-444 7.37e-17

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 83.47  E-value: 7.37e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469164934 113 IWKGDVKALQKIIHSKSKNLYEPNKDGWLPLHESAYYGSVKCLKILLKAKPEtINKQTNKSQTPLMLAVCRKHFSCVEHL 192
Cdd:PHA02874    9 IYSGDIEAIEKIIKNKGNCINISVDETTTPLIDAIRSGDAKIVELFIKHGAD-INHINTKIPHPLLTAIKIGAHDIIKLL 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469164934 193 LEQGADPNLannqwetpLYKACekANEAIVELLLRFGASPTKACAQGGTPLHEAVRNKKLKITKMLIKAGAKLCAKNIYG 272
Cdd:PHA02874   88 IDNGVDTSI--------LPIPC--IEKDMIKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNG 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469164934 273 IDSLFMAAQCNSVEVLNYLIYKGGNVNTQANDDASALFEACKNGHAKAVEILLSQSADVNITNKTGLLPIHVAAKNGHdS 352
Cdd:PHA02874  158 CYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAIIHNR-S 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469164934 353 IVAMLIPRTSMVKVRSSGISSLHFAAENNKD-SVLEILIDAGYDVNAKMSD-----DWSKMYEDhRSTALYSAVANsnie 426
Cdd:PHA02874  237 AIELLINNASINDQDIDGSTPLHHAINPPCDiDIIDILLYHKADISIKDNKgenpiDTAFKYIN-KDPVIKDIIAN---- 311

                         330
                  ....*....|....*...
gi 1469164934 427 aATMLLEAGADPNLDIFN 444
Cdd:PHA02874  312 -AVLIKEADKLKDSDFLE 328
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 159-451 3.66e-16

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 81.46  E-value: 3.66e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469164934 159 LKAKPETINKQTNKSQT-------PLMLAVCRKHFSCVEHLLEQGADPNLANNQWETPLYKACEKANE-AIVELLlrfgA 230
Cdd:PHA02878   16 ILKYIEYIDHTENYSTSaslipfiPLHQAVEARNLDVVKSLLTRGHNVNQPDHRDLTPLHIICKEPNKlGMKEMI----R 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469164934 231 SPTKaCAQGGT--PLHEAVRNKKLKITKMLIKAGaklcAKNIYGIDSLFMAAQCNS----VEVLNYLIYKGGNVNTQ-AN 303
Cdd:PHA02878   92 SINK-CSVFYTlvAIKDAFNNRNVEIFKIILTNR----YKNIQTIDLVYIDKKSKDdiieAEITKLLLSYGADINMKdRH 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469164934 304 DDASALFEACKNGHAKAVEILLSQSADVNITNKTGLLPIHVAAKNGHDSIVAMLIPRTSMVKVRSS-GISSLHFAAENNK 382
Cdd:PHA02878  167 KGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKcGNTPLHISVGYCK 246

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1469164934 383 D-SVLEILIDAGYDVNAKMSddwskmyeDHRSTALYSAVANSNIeaATMLLEAGADPNL---DIFNPLLVAVR 451
Cdd:PHA02878  247 DyDILKLLLEHGVDVNAKSY--------ILGLTALHSSIKSERK--LKLLLEYGADINSlnsYKLTPLSSAVK 309
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 104-333 1.40e-15

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 79.26  E-value: 1.40e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469164934 104 NDLDPILSAIWKGDVKALQKIIHSKsknlYEPN---KDGWLPLHESAYYGSVKCLKILLK--AKPetiNKQTNKSQTPLM 178
Cdd:PHA02875    1 MDQVALCDAILFGELDIARRLLDIG----INPNfeiYDGISPIKLAMKFRDSEAIKLLMKhgAIP---DVKYPDIESELH 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469164934 179 LAVCRKHFSCVEHLLEQGADPN-LANNQWETPLYKACEKANEAIVELLLRFGASPTKACAQGGTPLHEAVRNKKLKITKM 257
Cdd:PHA02875   74 DAVEEGDVKAVEELLDLGKFADdVFYKDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIEL 153

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1469164934 258 LIKAGAKLCAKNIYGIDSLFMAAQCNSVEVLNYLIYKGGNVN-TQANDDASALFEACKNGHAKAVEILLSQSADVNI 333
Cdd:PHA02875  154 LIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANIDyFGKNGCVAALCYAIENNKIDIVRLFIKRGADCNI 230
SOCS_ASB_like cd03716
SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB ...
 599-638 2.30e-15

SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB (SPRY domain-containing SOCS box proteins) protein families. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence of a variable number of repeats. SSB proteins contain a central SPRY domain and a C-terminal SOCS. Recently, it has been shown that all four SSB proteins interact with the MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF), and that SSB-1, SSB-2, and SSB-4 interact with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain.


Pssm-ID: 239686  Cd Length: 42  Bit Score: 70.22  E-value: 2.30e-15
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1469164934 599 PCTLMHLCRLKIRQRLGIQRLCHISALPLPERLIMFLNYE 638
Cdd:cd03716     3 PRSLQHLCRLAIRRCLGRRRLELIKKLPLPPRLKDYLLYE 42
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 108-390 2.52e-15

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 78.47  E-value: 2.52e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469164934 108 PILSAIWKGDVKALQKIIHSKSK----NLYEPNkdgwlPLHESAYYGSVKCLKILLkakpetinkqTNKSQTPLMLAVCR 183
Cdd:PHA02874   38 PLIDAIRSGDAKIVELFIKHGADinhiNTKIPH-----PLLTAIKIGAHDIIKLLI----------DNGVDTSILPIPCI 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469164934 184 KHfSCVEHLLEQGADPNLANNQWETPLYKACEKANEAIVELLLRFGASPTKACAQGGTPLHEAVRNKKLKITKMLIKAGA 263
Cdd:PHA02874  103 EK-DMIKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGA 181

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469164934 264 KLCAKNIYGIDSLFMAAQCNSVEVLNYLIYKGGNVNTQANDDASALFEACKngHAKAVEILLSQSADVNITNKTGLLPIH 343
Cdd:PHA02874  182 YANVKDNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAII--HNRSAIELLINNASINDQDIDGSTPLH 259

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1469164934 344 VAAKNGHD-SIVAMLIPRTSMVKVR-SSGISSLHFAAEN-NKDSVLEILI 390
Cdd:PHA02874  260 HAINPPCDiDIIDILLYHKADISIKdNKGENPIDTAFKYiNKDPVIKDII 309
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 174-397 2.66e-15

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 78.49  E-value: 2.66e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469164934 174 QTPLMLAVCRKHFSCVEHLLEQGADPNLANNQWETPLYKACEKANEAIVELLLRFGASPTKACAQGGTPLHEAVRNKKLK 253
Cdd:PHA02875    3 QVALCDAILFGELDIARRLLDIGINPNFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVK 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469164934 254 ITKMLIKAGaKLCAKNIY--GIDSLFMAAQCNSVEVLNYLIYKGGNVNTQANDDASALFEACKNGHAKAVEILLSQSADV 331
Cdd:PHA02875   83 AVEELLDLG-KFADDVFYkdGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACL 161

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1469164934 332 NITNKTGLLPIHVAAKNGHDSIVAMLIPRTSMVKV--RSSGISSLHFAAENNKDSVLEILIDAGYDVN 397
Cdd:PHA02875  162 DIEDCCGCTPLIIAMAKGDIAICKMLLDSGANIDYfgKNGCVAALCYAIENNKIDIVRLFIKRGADCN 229
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 190-471 2.92e-15

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 79.34  E-value: 2.92e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469164934 190 EHLLEQGADPNLANNQWETPLYKACEKANEAIVELLLRFGASPTKACAQGGTPLH------------------------- 244
Cdd:PHA02876  162 EMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLEcavdsknidtikaiidnrsninknd 241

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469164934 245 ----EAVRNKKLKITKMLIKAGAKLCAKNIYGIDSLFMAAQCNSVEVL-NYLIYKGGNVNTQANDDASALFEACKNGH-A 318
Cdd:PHA02876  242 lsllKAIRNEDLETSLLLYDAGFSVNSIDDCKNTPLHHASQAPSLSRLvPKLLERGADVNAKNIKGETPLYLMAKNGYdT 321

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469164934 319 KAVEILLSQSADVNITNKTGLLPIHVAAK-NGHDSIVAMLIPRTSMVKVRS-SGISSLHFAAENNKDSVLEILIDAGYDV 396
Cdd:PHA02876  322 ENIRTLIMLGADVNAADRLYITPLHQASTlDRNKDIVITLLELGANVNARDyCDKTPIHYAAVRNNVVIINTLLDYGADI 401

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469164934 397 NAkmsddwskmYEDHRSTALYSAVANSN-IEAATMLLEAGAD---PNLDIFNPLLVAVRIG-SMEMVALLLKHGANVNAM 471
Cdd:PHA02876  402 EA---------LSQKIGTALHFALCGTNpYMSVKTLIDRGANvnsKNKDLSTPLHYACKKNcKLDVIEMLLDNGADVNAI 472
Ank_2 pfam12796
Ankyrin repeats (3 copies);
276-358 4.44e-15

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 70.92  E-value: 4.44e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469164934 276 LFMAAQCNSVEVLNYLIYKGGNVNTQANDDASALFEACKNGHAKAVEILLSQsADVNITNKtGLLPIHVAAKNGHDSIVA 355
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKDN-GRTALHYAARSGHLEIVK 78


                  ...
gi 1469164934 356 MLI 358
Cdd:pfam12796  79 LLL 81
PHA03095 PHA03095
ankyrin-like protein; Provisional
 142-360 1.07e-14

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 76.99  E-value: 1.07e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469164934 142 PLHESAYYGSVKCLKI---LLKAKPEtINKQTNKSQTPLMLAVCrkhFSCVEH----LLEQGADPNLANNQWETPL--YK 212
Cdd:PHA03095   50 PLHLYLHYSSEKVKDIvrlLLEAGAD-VNAPERCGFTPLHLYLY---NATTLDviklLIKAGADVNAKDKVGRTPLhvYL 125

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469164934 213 ACEKANEAIVELLLRFGASPTKACAQGGTPLHEAVRNKK--LKITKMLIKAGAKLCAKNIYG------------------ 272
Cdd:PHA03095  126 SGFNINPKVIRLLLRKGADVNALDLYGMTPLAVLLKSRNanVELLRLLIDAGADVYAVDDRFrsllhhhlqsfkprariv 205

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469164934 273 --------------------IDSLFMAAQCNSVEVLNYLIyKGGNVNTQANDDASALFEACKNGHAKAVEILLSQSADVN 332
Cdd:PHA03095  206 reliragcdpaatdmlgntpLHSMATGSSCKRSLVLPLLI-AGISINARNRYGQTPLHYAAVFNNPRACRRLIALGADIN 284

                         250       260
                  ....*....|....*....|....*...
gi 1469164934 333 ITNKTGLLPIHVAAKNGHDSIVAMLIPR 360
Cdd:PHA03095  285 AVSSDGNTPLSLMVRNNNGRAVRAALAK 312
SOCS cd03587
SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region ...
 599-638 1.49e-14

SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins with a SOCS box), and WSBs (WD40 repeat-containing proteins with a SOCS box), as well as, other miscellaneous proteins. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239641  Cd Length: 41  Bit Score: 67.88  E-value: 1.49e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1469164934 599 PCTLMHLCRLKIRQRLGIQRLCHISALPLPERLIMFLNYE 638
Cdd:cd03587     2 PRSLQHLCRLAIRRCLGKRRLDLIDKLPLPPRLKDYLLYK 41
Ank_2 pfam12796
Ankyrin repeats (3 copies);
143-233 2.39e-14

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 68.99  E-value: 2.39e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469164934 143 LHESAYYGSVKCLKILLKAKPEtINKQTNKSQTPLMLAVCRKHFSCVEHLLEQgADPNLANNQWeTPLYKACEKANEAIV 222
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGAD-ANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKDNGR-TALHYAARSGHLEIV 77

                          90
                  ....*....|.
gi 1469164934 223 ELLLRFGASPT 233
Cdd:pfam12796  78 KLLLEKGADIN 88
Ank_2 pfam12796
Ankyrin repeats (3 copies);
243-335 8.25e-14

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 67.45  E-value: 8.25e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469164934 243 LHEAVRNKKLKITKMLIKAGAKLCAKNIYGIDSLFMAAQCNSVEVLNYLIyKGGNVNTQaNDDASALFEACKNGHAKAVE 322
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLL-EHADVNLK-DNGRTALHYAARSGHLEIVK 78

                          90
                  ....*....|...
gi 1469164934 323 ILLSQSADVNITN 335
Cdd:pfam12796  79 LLLEKGADINVKD 91
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 153-299 8.30e-14

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 74.15  E-value: 8.30e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469164934 153 KCLKILLKAKPETINKQTNKSQTPLMLAVCRKHFSCVEHLLEQGADPNLANNQWETPLYKACEKANEAIVELLLRFGASP 232
Cdd:PHA02878  148 EITKLLLSYGADINMKDRHKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGAST 227

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1469164934 233 TKACAQGGTPLHEAV-RNKKLKITKMLIKAGAKLCAKN-IYGIDSLFMAAQcnSVEVLNYLIYKGGNVN 299
Cdd:PHA02878  228 DARDKCGNTPLHISVgYCKDYDILKLLLEHGVDVNAKSyILGLTALHSSIK--SERKLKLLLEYGADIN 294
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 272-471 2.90e-13

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 71.95  E-value: 2.90e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469164934 272 GIDSLFMAAQCNSVEVLNYLIYKGGNVNTQANDDASALFEACKNGHAKAVEILLSQSADVN-ITNKTGLLPIHVAAKNGH 350
Cdd:PHA02875   35 GISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVKAVEELLDLGKFADdVFYKDGMTPLHLATILKK 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469164934 351 DSIVAMLIPRTSMVKVRSSG-ISSLHFAAENNKDSVLEILIDAGYDVNakmsddwskmYED-HRSTALYSAVANSNIEAA 428
Cdd:PHA02875  115 LDIMKLLIARGADPDIPNTDkFSPLHLAVMMGDIKGIELLIDHKACLD----------IEDcCGCTPLIIAMAKGDIAIC 184

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 1469164934 429 TMLLEAGADPNLDIFNP----LLVAVRIGSMEMVALLLKHGANVNAM 471
Cdd:PHA02875  185 KMLLDSGANIDYFGKNGcvaaLCYAIENNKIDIVRLFIKRGADCNIM 231
Ank_2 pfam12796
Ankyrin repeats (3 copies);
112-203 1.78e-12

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 63.60  E-value: 1.78e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469164934 112 AIWKGDVKALQKIIHSKSkNLYEPNKDGWLPLHESAYYGSVKCLKILLKAKPetINKQTNKsQTPLMLAVCRKHFSCVEH 191
Cdd:pfam12796   4 AAKNGNLELVKLLLENGA-DANLQDKNGRTALHLAAKNGHLEIVKLLLEHAD--VNLKDNG-RTALHYAARSGHLEIVKL 79

                          90
                  ....*....|..
gi 1469164934 192 LLEQGADPNLAN 203
Cdd:pfam12796  80 LLEKGADINVKD 91
Ank_2 pfam12796
Ankyrin repeats (3 copies);
374-471 1.90e-12

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 63.60  E-value: 1.90e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469164934 374 LHFAAENNKDSVLEILIDAGYDVNAKMSDDWskmyedhrsTALYSAVANSNIEAATMLLE-AGADPNLDIFNPLLVAVRI 452
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGR---------TALHLAAKNGHLEIVKLLLEhADVNLKDNGRTALHYAARS 71

                          90
                  ....*....|....*....
gi 1469164934 453 GSMEMVALLLKHGANVNAM 471
Cdd:pfam12796  72 GHLEIVKLLLEKGADINVK 90
SOCS_box pfam07525
SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more ...
 599-635 3.64e-12

SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.


Pssm-ID: 462192  Cd Length: 39  Bit Score: 61.03  E-value: 3.64e-12
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1469164934 599 PCTLMHLCRLKIRQRLGIQRLCHISALPLPERLIMFL 635
Cdd:pfam07525   2 PRSLQHLCRLAIRRALGKRRLGAIDKLPLPPLLKDYL 38
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 108-244 5.56e-12

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 68.89  E-value: 5.56e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469164934 108 PILSAIWKGDVKALQKIIHSKSKNLYEPNKDGWLPLHESAYYGSVKCLKILLKAKPETINK----QTNKSQTPLMLAVCR 183
Cdd:cd22192    20 PLLLAAKENDVQAIKKLLKCPSCDLFQRGALGETALHVAALYDNLEAAVVLMEAAPELVNEpmtsDLYQGETALHIAVVN 99

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1469164934 184 KHFSCVEHLLEQGAD------------PNLANNQW--ETPL-YKACEkANEAIVELLLRFGASPTKACAQGGTPLH 244
Cdd:cd22192   100 QNLNLVRELIARGADvvspratgtffrPGPKNLIYygEHPLsFAACV-GNEEIVRLLIEHGADIRAQDSLGNTVLH 174
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 189-335 2.38e-11

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 66.82  E-value: 2.38e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469164934 189 VEHLLEQGADPNLANNQWETPLYKACEKANEAIVELLLRFGASPTKACAQGGTPLHEAVRNKKLKITKMLIKAGAklcAK 268
Cdd:PLN03192  541 LEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHKIFRILYHFAS---IS 617

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1469164934 269 NIY-GIDSLFMAAQCNSVEVLNYLIYKGGNVNTQANDDASALFEACKNGHAKAVEILLSQSADVNITN 335
Cdd:PLN03192  618 DPHaAGDLLCTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGADVDKAN 685
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 371-502 2.91e-11

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 65.84  E-value: 2.91e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469164934 371 ISSLHFAAENNKDSVLEILIDAGYDVNAKMSDDWSKMYedhrSTALYSAVANSNIEAATMLLEAGADPNLDIFN---PLL 447
Cdd:PHA03100   36 VLPLYLAKEARNIDVVKILLDNGADINSSTKNNSTPLH----YLSNIKYNLTDVKEIVKLLLEYGANVNAPDNNgitPLL 111

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1469164934 448 VAV--RIGSMEMVALLLKHGANVNAMLPTHPTSFPAALVFCLRFMLMMKCLLDNGCD 502
Cdd:PHA03100  112 YAIskKSNSYSIVEYLLDNGANVNIKNSDGENLLHLYLESNKIDLKILKLLIDKGVD 168
SOCS_ASB2 cd03721
SOCS (suppressors of cytokine signaling) box of ASB2-like proteins. ASB family members have a ...
 599-638 3.74e-11

SOCS (suppressors of cytokine signaling) box of ASB2-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB2 targets specific proteins to destruction by the proteasome in leukemia cells that have been induced to differentiate. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239691  Cd Length: 45  Bit Score: 58.34  E-value: 3.74e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1469164934 599 PCTLMHLCRLKIRQRLGIQRLCHISALPLPERLIMFLNYE 638
Cdd:cd03721     3 PRPLAHLCRLKVRTLIGINRIKLIDTLPLPPRLIRYLNHQ 42
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 184-475 9.09e-11

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 64.21  E-value: 9.09e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469164934 184 KHFSCVEHLLE-QGADPNLANNQWETPLYKACEKANEAIVELLLRFGASPTKACAQGGTPLHEAVRNKKLKITKMLIkag 262
Cdd:PHA02874   12 GDIEAIEKIIKnKGNCINISVDETTTPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLI--- 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469164934 263 aklcaknIYGIDSLFMAAQCNSVEVLNYLIYKGGNVNTQANDDASALFEACKNGHAKAVEILLSQSADVNITNKTGLLPI 342
Cdd:PHA02874   89 -------DNGVDTSILPIPCIEKDMIKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPI 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469164934 343 HVAAKNghdsivamliprtsmvkvrssgisslhfaaenNKDSVLEILIDAGydvnakmsddwskmyedhrstaLYSAVAN 422
Cdd:PHA02874  162 HIAIKH--------------------------------NFFDIIKLLLEKG----------------------AYANVKD 187

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1469164934 423 SNIEAatmlleagadpnldifnPLLVAVRIGSMEMVALLLKHGANV-----NAMLPTH 475
Cdd:PHA02874  188 NNGES-----------------PLHNAAEYGDYACIKLLIDHGNHImnkckNGFTPLH 228
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 243-505 9.26e-11

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 65.08  E-value: 9.26e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469164934 243 LHEAVRNKKLKITKMLIKAGAKLCAKNIYGIDSLFMAAQCNSVEVLNYLIYKGGNVNTQANDDASALFEACKNGHAKAVE 322
Cdd:PHA02876  149 IKERIQQDELLIAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIK 228

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469164934 323 ILLSQSADVN---------ITN---KTGLL-----------------PIHVAAKNGHDS-IVAMLIPRTSMVKVRS-SGI 371
Cdd:PHA02876  229 AIIDNRSNINkndlsllkaIRNedlETSLLlydagfsvnsiddckntPLHHASQAPSLSrLVPKLLERGADVNAKNiKGE 308

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469164934 372 SSLHFAAENNKDSV-LEILIDAGYDVNAKmsddwSKMYedhrSTALYSA-VANSNIEAATMLLEAGADPNLDIF---NPL 446
Cdd:PHA02876  309 TPLYLMAKNGYDTEnIRTLIMLGADVNAA-----DRLY----ITPLHQAsTLDRNKDIVITLLELGANVNARDYcdkTPI 379

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1469164934 447 LVAVRIGSMEMVALLLKHGANVNAMLPTHPTSFPAALVFCLRFMlMMKCLLDNGCDAQS 505
Cdd:PHA02876  380 HYAAVRNNVVIINTLLDYGADIEALSQKIGTALHFALCGTNPYM-SVKTLIDRGANVNS 437
PHA03095 PHA03095
ankyrin-like protein; Provisional
 139-327 3.31e-10

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 62.73  E-value: 3.31e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469164934 139 GWLPLHESAYYGSV-KCLKILLKAKPEtINKQTNKSQTPL--MLAVCRKHFSCVEHLLEQGADPNLANNQWETPLY---- 211
Cdd:PHA03095   83 GFTPLHLYLYNATTlDVIKLLIKAGAD-VNAKDKVGRTPLhvYLSGFNINPKVIRLLLRKGADVNALDLYGMTPLAvllk 161

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469164934 212 --------------KACE-------------------KANEAIVELLLRFGASPTKACAQGGTPLHEAVRNKKLKITKM- 257
Cdd:PHA03095  162 srnanvellrllidAGADvyavddrfrsllhhhlqsfKPRARIVRELIRAGCDPAATDMLGNTPLHSMATGSSCKRSLVl 241

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1469164934 258 -LIKAGAKLCAKNIYGIDSLFMAAQCNSVEVLNYLIYKGGNVNTQANDDASALFEACKNGHAKAVEILLSQ 327
Cdd:PHA03095  242 pLLIAGISINARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDGNTPLSLMVRNNNGRAVRAALAK 312
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 305-469 1.64e-09

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 60.39  E-value: 1.64e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469164934 305 DASALFEACKNGHAKAVEILLSQSADVNITNKTGLLPIHVAAKNGHDSIVAMLIPRTSMVKVRSSGISS-LHFAAENNKD 383
Cdd:PHA02875    2 DQVALCDAILFGELDIARRLLDIGINPNFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESeLHDAVEEGDV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469164934 384 SVLEILIDAGydvnaKMSDDwsKMYEDHrSTALYSAVANSNIEAATMLLEAGADP---NLDIFNPLLVAVRIGSMEMVAL 460
Cdd:PHA02875   82 KAVEELLDLG-----KFADD--VFYKDG-MTPLHLATILKKLDIMKLLIARGADPdipNTDKFSPLHLAVMMGDIKGIEL 153


                  ....*....
gi 1469164934 461 LLKHGANVN 469
Cdd:PHA02875  154 LIDHKACLD 162
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 97-231 2.73e-09

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 59.68  E-value: 2.73e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469164934  97 QVTVEYMNDLDPILSAIWK--GDVKALQKIIHsKSKNLYEPNKDGWLPLHESAYYGSV--KCLKILLK------AKPET- 165
Cdd:PHA03100   98 NVNAPDNNGITPLLYAISKksNSYSIVEYLLD-NGANVNIKNSDGENLLHLYLESNKIdlKILKLLIDkgvdinAKNRVn 176

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1469164934 166 --------INKQTNKSQTPLMLAVCRKHFSCVEHLLEQGADPNLANNQWETPLYKACEKANEAIVELLLRFGAS 231
Cdd:PHA03100  177 yllsygvpINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPS 250
SOCS_ASB1 cd03720
SOCS (suppressors of cytokine signaling) box of ASB1-like proteins. ASB family members have a ...
 599-638 3.43e-09

SOCS (suppressors of cytokine signaling) box of ASB1-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239690  Cd Length: 42  Bit Score: 52.81  E-value: 3.43e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1469164934 599 PCTLMHLCRLKIRQRLGIQRLCHISALPLPERLIMFLNYE 638
Cdd:cd03720     3 PRSLLSLCRIAVRRALGKQRLSLICSLPLPDPIKKFLLHE 42
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 209-470 7.21e-09

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 58.35  E-value: 7.21e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469164934 209 PLYKACEKANEAIVELLLRFGASPTKACAQGGTPLHEAVRNKKLKITKMLIKAGAKLCAKNIY-GIDSLFmaaQCNSVEV 287
Cdd:PHA02878   40 PLHQAVEARNLDVVKSLLTRGHNVNQPDHRDLTPLHIICKEPNKLGMKEMIRSINKCSVFYTLvAIKDAF---NNRNVEI 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469164934 288 LNYLIykggnVNTQANDDASALFEACKNGH-----AKAVEILLSQSADVNItnktgllpihvaaknghdsivamliprts 362
Cdd:PHA02878  117 FKIIL-----TNRYKNIQTIDLVYIDKKSKddiieAEITKLLLSYGADINM----------------------------- 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469164934 363 mvKVRSSGISSLHFAAENNKDSVLEILIDAGYDVNAKMSDDWSKMYEdhrstalysAVANSNIEAATMLLEAGAdpNLDI 442
Cdd:PHA02878  163 --KDRHKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHH---------AVKHYNKPIVHILLENGA--STDA 229

                         250       260       270
                  ....*....|....*....|....*....|....
gi 1469164934 443 FN-----PLLVAV-RIGSMEMVALLLKHGANVNA 470
Cdd:PHA02878  230 RDkcgntPLHISVgYCKDYDILKLLLEHGVDVNA 263
SOCS_SSB4 cd03743
SOCS (suppressors of cytokine signaling) box of SSB4 (SPRY domain-containing SOCS box ...
 599-638 1.03e-08

SOCS (suppressors of cytokine signaling) box of SSB4 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB4 has been shown to bind to MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF). SSB4, like SSB2 and SSB1, also interacts with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239712  Cd Length: 42  Bit Score: 51.50  E-value: 1.03e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1469164934 599 PCTLMHLCRLKIRQRLGIQRLCHISALPLPERLIMFLNYE 638
Cdd:cd03743     3 PLPLMDLCRRSARQALGRHRLHHIQSLPLPQTLKNYLQYQ 42
SOCS_ASB15 cd03731
SOCS (suppressors of cytokine signaling) box of ASB15-like proteins. ASB family members have a ...
 599-638 9.38e-08

SOCS (suppressors of cytokine signaling) box of ASB15-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Human ASB15 is expressed predominantly in skeletal muscle and participates in the regulation of protein turnover and muscle cell development by stimulating protein synthesis and regulating differentiation of muscle cells. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239701  Cd Length: 56  Bit Score: 49.06  E-value: 9.38e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1469164934 599 PCTLMHLCRLKIRQRLGIQRLCHISA---LPLP---ERLIMFLNYE 638
Cdd:cd03731     3 PRPLKHLCRLKIRKLMGLQKLQQPSSmkkLPLPpalKRYILYKEYD 48
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 276-502 1.32e-07

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 54.50  E-value: 1.32e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469164934 276 LFMAAQCNSVEVLNYLIYKGGNVNTQANDDASALFEACKNGHAKAVEILLSQSADVNITNKtgLLPIHVAAKNGHDSIVA 355
Cdd:PHA02878   41 LHQAVEARNLDVVKSLLTRGHNVNQPDHRDLTPLHIICKEPNKLGMKEMIRSINKCSVFYT--LVAIKDAFNNRNVEIFK 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469164934 356 MLIpRTSMVKVRSSGISSLhfaAENNKDSVLE-----ILIDAGYDVNAKMsddwskmyEDHRSTALYSAVANSNIEAATM 430
Cdd:PHA02878  119 IIL-TNRYKNIQTIDLVYI---DKKSKDDIIEaeitkLLLSYGADINMKD--------RHKGNTALHYATENKDQRLTEL 186

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1469164934 431 LLEAGADPN-LDIFN--PLLVAVRIGSMEMVALLLKHGANVNAMLPTHPTSFPAALVFCLRFMLmMKCLLDNGCD 502
Cdd:PHA02878  187 LLSYGANVNiPDKTNnsPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLHISVGYCKDYDI-LKLLLEHGVD 260
SOCS_box smart00969
The SOCS box acts as a bridge between specific substrate- binding domains and more generic ...
 600-638 1.40e-07

The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases;


Pssm-ID: 198037  Cd Length: 34  Bit Score: 47.79  E-value: 1.40e-07
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1469164934  600 CTLMHLCRLKIRQRLGiqrlcHISALPLPERLIMFLNYE 638
Cdd:smart00969   1 RSLQHLCRLAIRRSLG-----GIDKLPLPPRLKDYLLYY 34
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 192-260 2.13e-07

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 54.13  E-value: 2.13e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1469164934 192 LLEQGADPNLANNQWETPLYKACEKANEAIVELLLRFGASPTKACAQGGTPLHEAVRNKKLKITKMLIK 260
Cdd:PTZ00322  101 LLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSR 169
Ank_4 pfam13637
Ankyrin repeats (many copies);
307-358 3.06e-07

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 47.27  E-value: 3.06e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1469164934 307 SALFEACKNGHAKAVEILLSQSADVNITNKTGLLPIHVAAKNGHDSIVAMLI 358
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 334-470 6.48e-07

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 52.32  E-value: 6.48e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469164934 334 TNKTGLLPIHVAAK-NGHDSIVAMLI-PRTSMVKVRSSGISSLHFAAENNKDSVLEILIDAGYD-VNAKMSddwSKMYED 410
Cdd:cd22192    13 QKRISESPLLLAAKeNDVQAIKKLLKcPSCDLFQRGALGETALHVAALYDNLEAAVVLMEAAPElVNEPMT---SDLYQG 89

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1469164934 411 HrsTALYSAVANSNIEAATMLLEAGADP---------------NLDIF--NPLLVAVRIGSMEMVALLLKHGANVNA 470
Cdd:cd22192    90 E--TALHIAVVNQNLNLVRELIARGADVvspratgtffrpgpkNLIYYgeHPLSFAACVGNEEIVRLLIEHGADIRA 164
SOCS_SSB1_4 cd03718
SOCS (suppressors of cytokine signaling) box of SSB1 and SSB4 (SPRY domain-containing SOCS box ...
 599-638 6.63e-07

SOCS (suppressors of cytokine signaling) box of SSB1 and SSB4 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB1 and SSB4 has been shown to bind to MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF) and also interacts with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239688  Cd Length: 42  Bit Score: 46.14  E-value: 6.63e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1469164934 599 PCTLMHLCRLKIRQRLGIQRLCHISALPLPERLIMFLNYE 638
Cdd:cd03718     3 PLPLMDLCRRRVRVALGRDRLEEIEQLPLPPSLKNYLLYQ 42
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 147-305 7.94e-07

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 52.56  E-value: 7.94e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469164934 147 AYYGSVKCLKILLKAKPETiNKQTNKSQTPLMLAVCRKHFSCVEHLLEQGADPNLANNQWETPLYKACEKANEAIVELLL 226
Cdd:PLN03192  533 ASTGNAALLEELLKAKLDP-DIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHKIFRILY 611

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469164934 227 RFG-ASPTKAcaqGGTPLHEAVRNKKLKITKMLIKAGAKLCAKNIYGIDSLFMAAQCNSVEVLNYLIYKGGNVNTQANDD 305
Cdd:PLN03192  612 HFAsISDPHA---AGDLLCTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGADVDKANTDD 688
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 299-437 1.79e-06

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 51.41  E-value: 1.79e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469164934 299 NTQANDD---ASALFEACKNGHAKAVEILLSQSADVNITNKTGLLPIHVAAKNGHDSIVAMLIPRTSMVKVRS------- 368
Cdd:PLN03192  516 NGGEHDDpnmASNLLTVASTGNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDangntal 595

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469164934 369 -SGISSLH------------------------FAAENNKDSVLEILIDAGYDVNAkmsddwskmyEDHR-STALYSAVAN 422
Cdd:PLN03192  596 wNAISAKHhkifrilyhfasisdphaagdllcTAAKRNDLTAMKELLKQGLNVDS----------EDHQgATALQVAMAE 665

                         170
                  ....*....|....*
gi 1469164934 423 SNIEAATMLLEAGAD 437
Cdd:PLN03192  666 DHVDMVRLLIMNGAD 680
SOCS_SOCS7 cd03741
SOCS (suppressors of cytokine signaling) box of SOCS7-like proteins. Together with CIS1, the ...
 601-637 2.76e-06

SOCS (suppressors of cytokine signaling) box of SOCS7-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS7 is important in the functioning of neuronal cells. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239710  Cd Length: 49  Bit Score: 44.70  E-value: 2.76e-06
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1469164934 601 TLMHLCRLKIRQRLgiqRLCHISALPLPERLIMFLNY 637
Cdd:cd03741     5 SLQHLCRFVIRKLV---RRDHIPALPLPRRLIDYLRE 38
SOCS_SOCS_like cd03717
SOCS (suppressors of cytokine signaling) box of SOCS-like proteins. The CIS/SOCS family of ...
 601-637 2.88e-06

SOCS (suppressors of cytokine signaling) box of SOCS-like proteins. The CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. These intracellular proteins regulate the responses of immune cells to cytokines. Identified as negative regulators of the cytokine-JAK-STAT pathway, they seem to play a role in many immunological and pathological processes. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. Related SOCS boxes are also present in Rab40-like proteins and insect proteins of unknown function that also contain a NEUZ (domain in neuralized proteins) domain.


Pssm-ID: 239687  Cd Length: 39  Bit Score: 44.12  E-value: 2.88e-06
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1469164934 601 TLMHLCRLKIRQRLGIQrlcHISALPLPERLIMFLNY 637
Cdd:cd03717     5 SLQHLCRFVIRQCTRRD---LIDQLPLPRRLKDYLKE 38
Ank_5 pfam13857
Ankyrin repeats (many copies);
158-210 3.19e-06

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 44.64  E-value: 3.19e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1469164934 158 LLKAKPETINKQTNKSQTPLMLAVCRKHFSCVEHLLEQGADPNLANNQWETPL 210
Cdd:pfam13857   1 LLEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTAL 53
Ank_4 pfam13637
Ankyrin repeats (many copies);
208-259 3.22e-06

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 44.57  E-value: 3.22e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1469164934 208 TPLYKACEKANEAIVELLLRFGASPTKACAQGGTPLHEAVRNKKLKITKMLI 259
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
Ank_4 pfam13637
Ankyrin repeats (many copies);
175-226 4.82e-06

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 44.19  E-value: 4.82e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1469164934 175 TPLMLAVCRKHFSCVEHLLEQGADPNLANNQWETPLYKACEKANEAIVELLL 226
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
SOCS_SSB2 cd03719
SOCS (suppressors of cytokine signaling) box of SSB2 (SPRY domain-containing SOCS box proteins) ...
 599-638 6.78e-06

SOCS (suppressors of cytokine signaling) box of SSB2 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB2 has been shown to bind to MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF). SSB2, like SSB4 and SSB1, also interacts with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239689  Cd Length: 42  Bit Score: 43.47  E-value: 6.78e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1469164934 599 PCTLMHLCRLKIRQRLGIQRLCHISALPLPERLIMFLNYE 638
Cdd:cd03719     3 PHSLLHLSRLCVRHALGDTRLGQVSALPLPPAMKRYLLYQ 42
PHA02798 PHA02798
ankyrin-like protein; Provisional
 221-440 1.11e-05

ankyrin-like protein; Provisional


Pssm-ID: 222931 [Multi-domain]  Cd Length: 489  Bit Score: 48.29  E-value: 1.11e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469164934 221 IVELLLRFGASPTKACAQGGTPLHEAVRN-----KKLKITKMLIKAGAKLCAKNIYGIDSLFMA---AQCNSVEVLNYLI 292
Cdd:PHA02798   53 IVKLFINLGANVNGLDNEYSTPLCTILSNikdykHMLDIVKILIENGADINKKNSDGETPLYCLlsnGYINNLEILLFMI 132

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469164934 293 YKGGNVNTQANDDASALFEACKNGHA---KAVEILLSQSADVN-ITNKTGLLPIHVAAKNGHD----SIVAMLIPRTSMV 364
Cdd:PHA02798  133 ENGADTTLLDKDGFTMLQVYLQSNHHidiEIIKLLLEKGVDINtHNNKEKYDTLHCYFKYNIDridaDILKLFVDNGFII 212

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469164934 365 KVRSsgisslhfaaENNKDSVLEILIDAGYDVNAKMSD--DWSKMYEDHRS------TALYSAVANSNIEAATMLLEAGA 436
Cdd:PHA02798  213 NKEN----------KSHKKKFMEYLNSLLYDNKRFKKNilDFIFSYIDINQvdelgfNPLYYSVSHNNRKIFEYLLQLGG 282


                  ....
gi 1469164934 437 DPNL 440
Cdd:PHA02798  283 DINI 286
TRPV cd21882
Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily ...
 143-294 1.24e-05

Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily (TRPV), named after the vanilloid receptor 1 (TRPV1), consists of six members: four thermo-sensing channels (TRPV1, TRPV2, TRPV3, and TRPV4) and two Ca2+ selective channels (TRPV5 and TRPV6). The calcium-selective channels TRPV5 and TRPV6 can be heterotetramers and are important for general Ca2+ homeostasis. All four channels within the TRPV1-4 group show temperature-invoked currents when expressed in heterologous cell systems, ranging from activation at ~25C for TRPV4 to ~52C for TRPV2. The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains. The TRP family consists of membrane proteins that function as ion channels that communicate between the cell and its environment, by a vast array of physical or chemical stimuli, including radiation (in the form of temperature, infrared ,or light) and pressure (osmotic or mechanical). TRP channels are formed by a tetrameric complex of channel subunits. Based on sequence identity, the mammalian TRP channel family is classified into six subfamilies, with significant sequence similarity within the transmembrane domains, but very low similarity in their N- and C-terminal cytoplasmic regions. The six subfamilies are named based on their first member: TRPC (canonical), TRPV (vanilloid), TRPM (melastatin), TRPA (ankyrin), TRPML (mucolipin), and TRPP (polycystic).


Pssm-ID: 411975 [Multi-domain]  Cd Length: 600  Bit Score: 48.34  E-value: 1.24e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469164934 143 LHESAYY---GSVKCLKILLKAKPETINKQT----------NKSQTPLMLAVCRKHFSCVEHLLEQGADPNLANNQ---- 205
Cdd:cd21882    30 LHKAALNlndGVNEAIMLLLEAAPDSGNPKElvnapctdefYQGQTALHIAIENRNLNLVRLLVENGADVSARATGrffr 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469164934 206 ---------WETPL-YKACEKaNEAIVELLLRFGASPTKACAQ---GGTPLH-------EAVRNKKLKIT--KMLIKAGA 263
Cdd:cd21882   110 kspgnlfyfGELPLsLAACTN-QEEIVRLLLENGAQPAALEAQdslGNTVLHalvlqadNTPENSAFVCQmyNLLLSYGA 188

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1469164934 264 KLC-------AKNIYGIDSLFMAAQCNSVEVLNYLIYK 294
Cdd:cd21882   189 HLDptqqleeIPNHQGLTPLKLAAVEGKIVMFQHILQR 226
SOCS_ASB14 cd03730
SOCS (suppressors of cytokine signaling) box of ASB14-like proteins. ASB family members have a ...
 599-638 1.46e-05

SOCS (suppressors of cytokine signaling) box of ASB14-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239700  Cd Length: 57  Bit Score: 42.91  E-value: 1.46e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1469164934 599 PCTLMHLCRLKIRQRLGIQRL-CHI--SALPLPERLIMFLNYE 638
Cdd:cd03730     3 PRSLKHLCRLKIRACMGRLRLrCPVfmSFLPLPNRLKAYILYK 45
SOCS_SSB1 cd03744
SOCS (suppressors of cytokine signaling) box of SSB1 (SPRY domain-containing SOCS box proteins) ...
 599-638 2.05e-05

SOCS (suppressors of cytokine signaling) box of SSB1 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB1 has been shown to bind to MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF), both the absence and the presence of HGF and enhances the HGF-MET-induced mitogen-activated protein kinases Erk-transcription factor Elk-1-serum response elements (SRE) pathway. SSB1, like SSB2 and SSB4, also interacts with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239713  Cd Length: 42  Bit Score: 41.89  E-value: 2.05e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1469164934 599 PCTLMHLCRLKIRQRLGIQRLCHISALPLPERLIMFLNYE 638
Cdd:cd03744     3 PLPLMDLCRRSVRLALGRERLSEIHTLPLPASLKNYLLYQ 42
TRPV3 cd22194
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a ...
 207-360 2.13e-05

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a temperature-sensitive Transient Receptor Potential (TRP) ion channel that is activated by warm temperatures, synthetic small-molecule chemicals, and natural compounds from plants. TRPV3 function is regulated by physiological factors such as extracellular divalent cations and acidic pH, intracellular adenosine triphosphate, membrane voltage, and arachidonic acid. It is expressed in both neuronal and non-neuronal tissues including epidermal keratinocytes, epithelial cells in the gut, endothelial cells in blood vessels, and neurons in dorsal root ganglia and CNS. TRPV3 null mice have abnormal hair morphogenesis and compromised skin barrier function. It may play roles in inflammatory skin disorders, such as itch and pain sensation. TRPV3 is also expressed by many neuronal and non-neuronal tissues, showing that TRPV3 might play roles in other unknown cellular and physiological functions. TRPV3 belongs to the vanilloid TRP subfamily (TRPV), named after the founding member vanilloid receptor 1 (TRPV1). The structure of TRPV shows the typical topology features of all TRP ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.


Pssm-ID: 411978 [Multi-domain]  Cd Length: 680  Bit Score: 47.83  E-value: 2.13e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469164934 207 ETPLYKACEKANE---AIVELLLRFG-----------ASPTKACAQGGTPLHEAVRNKKLKITKMLIKAGAKL--CAKNI 270
Cdd:cd22194    95 KTCLMKALLNINEntkEIVRILLAFAeengildrfinAEYTEEAYEGQTALNIAIERRQGDIVKLLIAKGADVnaHAKGV 174

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469164934 271 ------------YGIDSLFMAAQCNSVEVLNYLIYKGGNV----NTQANDDASALFEACKNGHA------KAVEILLSQS 328
Cdd:cd22194   175 ffnpkykhegfyFGETPLALAACTNQPEIVQLLMEKESTDitsqDSRGNTVLHALVTVAEDSKTqndfvkRMYDMILLKS 254

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1469164934 329 ADVN---ITNKTGLLPIHVAAKNGHDSIVAMLIPR 360
Cdd:cd22194   255 ENKNletIRNNEGLTPLQLAAKMGKAEILKYILSR 289
Ank_4 pfam13637
Ankyrin repeats (many copies);
372-432 2.16e-05

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 42.26  E-value: 2.16e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1469164934 372 SSLHFAAENNKDSVLEILIDAGYDVNAKMSDDWskmyedhrsTALYSAVANSNIEAATMLL 432
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADINAVDGNGE---------TALHFAASNGNVEVLKLLL 54
SOCS_ASB7 cd03726
SOCS (suppressors of cytokine signaling) box of ASB7-like proteins. ASB family members have a ...
 599-638 2.97e-05

SOCS (suppressors of cytokine signaling) box of ASB7-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239696  Cd Length: 45  Bit Score: 41.76  E-value: 2.97e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1469164934 599 PCTLMHLCRLKIRQRLGIQRLCHISALPLPERLIMFLNYE 638
Cdd:cd03726     3 PRTLQDLCRIKIRHCIGLQNLKLLDELPIAKVMKDYLKHK 42
TRPV cd21882
Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily ...
 368-474 3.12e-05

Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily (TRPV), named after the vanilloid receptor 1 (TRPV1), consists of six members: four thermo-sensing channels (TRPV1, TRPV2, TRPV3, and TRPV4) and two Ca2+ selective channels (TRPV5 and TRPV6). The calcium-selective channels TRPV5 and TRPV6 can be heterotetramers and are important for general Ca2+ homeostasis. All four channels within the TRPV1-4 group show temperature-invoked currents when expressed in heterologous cell systems, ranging from activation at ~25C for TRPV4 to ~52C for TRPV2. The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains. The TRP family consists of membrane proteins that function as ion channels that communicate between the cell and its environment, by a vast array of physical or chemical stimuli, including radiation (in the form of temperature, infrared ,or light) and pressure (osmotic or mechanical). TRP channels are formed by a tetrameric complex of channel subunits. Based on sequence identity, the mammalian TRP channel family is classified into six subfamilies, with significant sequence similarity within the transmembrane domains, but very low similarity in their N- and C-terminal cytoplasmic regions. The six subfamilies are named based on their first member: TRPC (canonical), TRPV (vanilloid), TRPM (melastatin), TRPA (ankyrin), TRPML (mucolipin), and TRPP (polycystic).


Pssm-ID: 411975 [Multi-domain]  Cd Length: 600  Bit Score: 47.18  E-value: 3.12e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469164934 368 SSGISSLHFAAENNKDSVLE---ILIDAGYD-------VNAKMSDDWskmYEDHrsTALYSAVANSNIEAATMLLEAGAD 437
Cdd:cd21882    24 ATGKTCLHKAALNLNDGVNEaimLLLEAAPDsgnpkelVNAPCTDEF---YQGQ--TALHIAIENRNLNLVRLLVENGAD 98

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1469164934 438 PNL----DIFN------------PLLVAVRIGSMEMVALLLKHGANVNAMLPT 474
Cdd:cd21882    99 VSAratgRFFRkspgnlfyfgelPLSLAACTNQEEIVRLLLENGAQPAALEAQ 151
PHA03095 PHA03095
ankyrin-like protein; Provisional
 136-270 3.52e-05

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 46.56  E-value: 3.52e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469164934 136 NKDGWLPLHESAYYGSVKCLKIL-LKAKPETINKQTNKSQTPLMLAVCRKHFSCVEHLLEQGADPNLANNQWETPLYKAC 214
Cdd:PHA03095  219 DMLGNTPLHSMATGSSCKRSLVLpLLIAGISINARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDGNTPLSLMV 298

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1469164934 215 EKANEAIVELLLRfGASPTKACAQ--------GGTPLHEAvrnKKLKITKMLIKAGAKLCAKNI 270
Cdd:PHA03095  299 RNNNGRAVRAALA-KNPSAETVAAtlntasvaGGDIPSDA---TRLCVAKVVLRGAFSLLPEPI 358
PHA02946 PHA02946
ankyin-like protein; Provisional
 167-395 4.05e-05

ankyin-like protein; Provisional


Pssm-ID: 165256 [Multi-domain]  Cd Length: 446  Bit Score: 46.59  E-value: 4.05e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469164934 167 NKQTNKSQTPLMLAVCRKHFSCVEHLLEQGADPNLANNQWETPLYKACEKANEAI--VELLLRFGASPTKACAQGGTPLH 244
Cdd:PHA02946   66 NETDDDGNYPLHIASKINNNRIVAMLLTHGADPNACDKQHKTPLYYLSGTDDEVIerINLLVQYGAKINNSVDEEGCGPL 145

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469164934 245 EAVRNKKLKITKMLIKAGAKLCAKNIYGIDSL--FMAAQCNSVEVLNYLIYKGGNVNTQANDDASALFEACKNGhAKAVE 322
Cdd:PHA02946  146 LACTDPSERVFKKIMSIGFEARIVDKFGKNHIhrHLMSDNPKASTISWMMKLGISPSKPDHDGNTPLHIVCSKT-VKNVD 224

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1469164934 323 I--LLSQSADVNITNKTGLLPIHVAAKNGHDS-IVAMLIPRTSMVKVRSSGISSLHfaaenNKDSVLEILIDAG--YD 395
Cdd:PHA02946  225 IinLLLPSTDVNKQNKFGDSPLTLLIKTLSPAhLINKLLSTSNVITDQTVNICIFY-----DRDDVLEIINDKGkqYD 297
SOCS smart00253
suppressors of cytokine signalling; suppressors of cytokine signalling
 593-637 5.93e-05

suppressors of cytokine signalling; suppressors of cytokine signalling


Pssm-ID: 128549  Cd Length: 43  Bit Score: 40.74  E-value: 5.93e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 1469164934  593 KERSVLPCTLMHLCRLKIRQRLGIQrlcHISALPLPERLIMFLNY 637
Cdd:smart00253   1 LPRPSNVPSLQHLCRFTIRRCTRTD---QIKTLPLPPKLKDYLSY 42
SOCS_ASB_9_11 cd03728
SOCS (suppressors of cytokine signaling) box of ASB9 and 11 proteins. ASB family members have ...
 599-637 5.96e-05

SOCS (suppressors of cytokine signaling) box of ASB9 and 11 proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239698  Cd Length: 42  Bit Score: 40.54  E-value: 5.96e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1469164934 599 PCTLMHLCRLKIRQRLGIQRLCHISALPLPERLIMFLNY 637
Cdd:cd03728     3 PPSLMQLCRLCIRKCFGRKQHHKIHKLHLPEPLKHFLLY 41
SOCS_ASB3 cd03722
SOCS (suppressors of cytokine signaling) box of ASB3-like proteins. ASB family members have a ...
 602-638 6.36e-05

SOCS (suppressors of cytokine signaling) box of ASB3-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ABS3 has been shown to be negative regulator of TNF-R2-mediated cellular responses to TNF-alpha by direct targeting of tumor necrosis factor receptor II (TNF-R2) for ubiquitination and proteasome-mediated degradation. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239692  Cd Length: 51  Bit Score: 40.93  E-value: 6.36e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1469164934 602 LMHLCRLKIRQRLGIQRL---CHISALPLPERLIMFLNYE 638
Cdd:cd03722     6 LTHLCRLEIRSSLKSERLrsdSFICQLPLPRSLQDYLLYS 45
Ank_4 pfam13637
Ankyrin repeats (many copies);
239-292 6.38e-05

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 40.72  E-value: 6.38e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1469164934 239 GGTPLHEAVRNKKLKITKMLIKAGAKLCAKNIYGIDSLFMAAQCNSVEVLNYLI 292
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 278-357 6.53e-05

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 46.04  E-value: 6.53e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469164934 278 MAAQCNSVEVlNYLIYKGGNVNTQANDDASALFEACKNGHAKAVEILLSQSADVNITNKTGLLPIHVAAKNGHDSIVAML 357
Cdd:PTZ00322   89 LAASGDAVGA-RILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLL 167
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 174-204 6.94e-05

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 40.35  E-value: 6.94e-05
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1469164934 174 QTPLMLAVCR-KHFSCVEHLLEQGADPNLANN 204
Cdd:pfam00023   3 NTPLHLAAGRrGNLEIVKLLLSKGADVNARDK 34
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 375-464 7.88e-05

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 45.66  E-value: 7.88e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469164934 375 HFAAENnkDSV-LEILIDAGYDVNAKmsdDWskmyedHRSTALYSAVANSNIEAATMLLEAGADPNL---DIFNPLLVAV 450
Cdd:PTZ00322   88 QLAASG--DAVgARILLTGGADPNCR---DY------DGRTPLHIACANGHVQVVRVLLEFGADPTLldkDGKTPLELAE 156

                          90
                  ....*....|....
gi 1469164934 451 RIGSMEMVALLLKH 464
Cdd:PTZ00322  157 ENGFREVVQLLSRH 170
PHA02946 PHA02946
ankyin-like protein; Provisional
 211-343 8.46e-05

ankyin-like protein; Provisional


Pssm-ID: 165256 [Multi-domain]  Cd Length: 446  Bit Score: 45.43  E-value: 8.46e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469164934 211 YKACEKANEAIVELLLRFGASPTKACAQGGTPLHEAVRNKKLKITKMLIKAGAKLCAKNIYGIDSLFMAAQCNS--VEVL 288
Cdd:PHA02946   44 YCGIKGLDERFVEELLHRGYSPNETDDDGNYPLHIASKINNNRIVAMLLTHGADPNACDKQHKTPLYYLSGTDDevIERI 123

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1469164934 289 NYLIYKGGNVNTQANDDASALFEACKNGHAKAVEILLSQSADVNITNKTGLLPIH 343
Cdd:PHA02946  124 NLLVQYGAKINNSVDEEGCGPLLACTDPSERVFKKIMSIGFEARIVDKFGKNHIH 178
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 380-506 9.22e-05

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 45.43  E-value: 9.22e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469164934 380 NNKDSVLEILIDAGYDVNAKMSDDWSKMyedhRSTALYSAVANSNIEAATMLLEAGADPN---LDIFNPLLVAVRIGS-- 454
Cdd:PHA03100    7 LTKSRIIKVKNIKYIIMEDDLNDYSYKK----PVLPLYLAKEARNIDVVKILLDNGADINsstKNNSTPLHYLSNIKYnl 82

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1469164934 455 ---MEMVALLLKHGANVNAMLPTHPTSFPAALVFCLRFMLMMKCLLDNGCDAQSC 506
Cdd:PHA03100   83 tdvKEIVKLLLEYGANVNAPDNNGITPLLYAISKKSNSYSIVEYLLDNGANVNIK 137
PHA02798 PHA02798
ankyrin-like protein; Provisional
 249-469 1.29e-04

ankyrin-like protein; Provisional


Pssm-ID: 222931 [Multi-domain]  Cd Length: 489  Bit Score: 44.83  E-value: 1.29e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469164934 249 NKKLKITKMLIKAGAklcakNIYGIDSLFMAAQC----------NSVEVLNYLIYKGGNVNTQANDDASALFEACKNGHA 318
Cdd:PHA02798   48 SPSTDIVKLFINLGA-----NVNGLDNEYSTPLCtilsnikdykHMLDIVKILIENGADINKKNSDGETPLYCLLSNGYI 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469164934 319 KAVEILL---SQSADVNITNKTGLLPIHVAAKNGHD---SIVAMLIPRTSMVKVRSS--GISSLHFAAENNKD----SVL 386
Cdd:PHA02798  123 NNLEILLfmiENGADTTLLDKDGFTMLQVYLQSNHHidiEIIKLLLEKGVDINTHNNkeKYDTLHCYFKYNIDridaDIL 202

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469164934 387 EILIDAGYDVNAKMSDDWSKMYEDHRSTALYSAVANSNIEAATMLLEAGADPNLDIFNPLLVAVRIGSMEMVALLLKHGA 466
Cdd:PHA02798  203 KLFVDNGFIINKENKSHKKKFMEYLNSLLYDNKRFKKNILDFIFSYIDINQVDELGFNPLYYSVSHNNRKIFEYLLQLGG 282


                  ...
gi 1469164934 467 NVN 469
Cdd:PHA02798  283 DIN 285
Ank_4 pfam13637
Ankyrin repeats (many copies);
276-325 1.29e-04

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 39.95  E-value: 1.29e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1469164934 276 LFMAAQCNSVEVLNYLIYKGGNVNTQANDDASALFEACKNGHAKAVEILL 325
Cdd:pfam13637   5 LHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
SOCS_ASB4_ASB18 cd03723
SOCS (suppressors of cytokine signaling) box of ASB4 and ASB18 proteins. ASB family members ...
 599-640 1.30e-04

SOCS (suppressors of cytokine signaling) box of ASB4 and ASB18 proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Asb4 was identified as imprinted gene in mice. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239693  Cd Length: 48  Bit Score: 39.73  E-value: 1.30e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1469164934 599 PCTLMHLCRLKIRQRLGiqRLCH--ISALPLPERLIMFLNYERE 640
Cdd:cd03723     3 PRSLQHLCRCAIRKLLG--SRCHklVPQLSLPTSLKNYLLLEPE 44
Ank_4 pfam13637
Ankyrin repeats (many copies);
412-462 1.52e-04

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 39.95  E-value: 1.52e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1469164934 412 RSTALYSAVANSNIEAATMLLEAGADPNL---DIFNPLLVAVRIGSMEMVALLL 462
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAvdgNGETALHFAASNGNVEVLKLLL 54
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 156-239 1.59e-04

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 44.89  E-value: 1.59e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469164934 156 KILLKAKPETiNKQTNKSQTPLMLAVCRKHFSCVEHLLEQGADPNLANNQWETPLYKACEKANEAIVELLLRFGASPTKA 235
Cdd:PTZ00322   99 RILLTGGADP-NCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRHSQCHFEL 177


                  ....
gi 1469164934 236 CAQG 239
Cdd:PTZ00322  178 GANA 181
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 282-470 1.90e-04

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 44.69  E-value: 1.90e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469164934 282 CNSVEVLNY-LIYKGG----NVNTQAND--DASALFEACK-NGHAKAVEILLSQSADVnitnKTGLLPIHVAAKNGHDSI 353
Cdd:TIGR00870  22 LPAAERGDLaSVYRDLeepkKLNINCPDrlGRSALFVAAIeNENLELTELLLNLSCRG----AVGDTLLHAISLEYVDAV 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469164934 354 VAMLIPR---------TSMVKVRSS-----GISSLHFAAENNKDSVLEILIDAGYDVNAKMSDDWSkMYEDHRSTALYSA 419
Cdd:TIGR00870  98 EAILLHLlaafrksgpLELANDQYTseftpGITALHLAAHRQNYEIVKLLLERGASVPARACGDFF-VKSQGVDSFYHGE 176

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1469164934 420 vansnieaatmlleagadpnldifNPLLVAVRIGSMEMVALLLKHGANVNA 470
Cdd:TIGR00870 177 ------------------------SPLNAAACLGSPSIVALLSEDPADILT 203
TRPV1-4 cd22193
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 1-4; TRPV1-4 are ...
 172-292 2.32e-04

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 1-4; TRPV1-4 are thermo-sensing channels that function directly in temperature-sensing and nociception; they share substantial structural and functional properties. Transient Receptor Potential (TRP) ion channels activated by temperature (thermo TRPs) are important molecular players in acute, inflammatory, and chronic pain states. So far, 11 TRP channels in mammalian cells have been identified as thermosensitive TRP (thermo-TRP) channels. TRPV1-4 channels are activated by different heat temperatures, for example, TRPV1 and TRPV2 are activated by high temperatures (>43C and >55C, respectively). TRPV1-4 belong to the vanilloid TRP subfamily (TRPV), named after the founding member vanilloid receptor 1 (TRPV1). The structure of TRPV shows the typical topology features of all TRP ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.


Pssm-ID: 411977 [Multi-domain]  Cd Length: 607  Bit Score: 44.40  E-value: 2.32e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469164934 172 KSQTPLMLAVCRKHFSCVEHLLEQGADPNLANNQ--------------WETPLYKACEKANEAIVELLLRFGASPTKACA 237
Cdd:cd22193    75 EGQTALHIAIERRQGDIVALLVENGADVHAHAKGrffqpkyqgegfyfGELPLSLAACTNQPDIVQYLLENEHQPADIEA 154

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1469164934 238 Q---GGTPLHEAV-------RNKKL--KITKMLIKAGAKLCA-------KNIYGIDSLFMAAQCNSVEVLNYLI 292
Cdd:cd22193   155 QdsrGNTVLHALVtvadntkENTKFvtRMYDMILIRGAKLCPtveleeiRNNDGLTPLQLAAKMGKIEILKYIL 228
Ank_4 pfam13637
Ankyrin repeats (many copies);
106-159 2.66e-04

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 39.18  E-value: 2.66e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1469164934 106 LDPILSAIWKGDVKALqKIIHSKSKNLYEPNKDGWLPLHESAYYGSVKCLKILL 159
Cdd:pfam13637   2 LTALHAAAASGHLELL-RLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA02791 PHA02791
ankyrin-like protein; Provisional
 174-341 2.76e-04

ankyrin-like protein; Provisional


Pssm-ID: 165154 [Multi-domain]  Cd Length: 284  Bit Score: 43.49  E-value: 2.76e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469164934 174 QTPLMLAVCRKHFSCVEHLLEQGADPNLANNQWetPLYKACEKANEAIVELLLRFGASPTKACAQGGTPLHEAVRNKKLK 253
Cdd:PHA02791   31 HSALYYAIADNNVRLVCTLLNAGALKNLLENEF--PLHQAATLEDTKIVKILLFSGMDDSQFDDKGNTALYYAVDSGNMQ 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469164934 254 ITKMLIKAGAKLCAKNIYGID-SLFMAAQCNSVEVLNYLIYKggnvnTQANDDASALFE----ACKNGHAKAVEILLSQS 328
Cdd:PHA02791  109 TVKLFVKKNWRLMFYGKTGWKtSFYHAVMLNDVSIVSYFLSE-----IPSTFDLAILLScihiTIKNGHVDMMILLLDYM 183

                         170
                  ....*....|...
gi 1469164934 329 ADVNITNKTGLLP 341
Cdd:PHA02791  184 TSTNTNNSLLFIP 196
SOCS_ASB13 cd03729
SOCS (suppressors of cytokine signaling) box of ASB13-like proteins. ASB family members have a ...
 599-637 3.22e-04

SOCS (suppressors of cytokine signaling) box of ASB13-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239699  Cd Length: 42  Bit Score: 38.61  E-value: 3.22e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1469164934 599 PCTLMHLCRLKIRQRLGIQRLCHISALPLPERLIMFLNY 637
Cdd:cd03729     3 PLSLQQLCRINLRKALGTRALEKIAKLNIPNRIIDYLSY 41
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 415-473 3.32e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 43.44  E-value: 3.32e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1469164934 415 ALYSAVANSNIEAATMLLEAGADPNLDIFN---PLLVAVRIGSMEMVALLLKHGANVNAMLP 473
Cdd:PHA02875    5 ALCDAILFGELDIARRLLDIGINPNFEIYDgisPIKLAMKFRDSEAIKLLMKHGAIPDVKYP 66
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 105-253 3.74e-04

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 43.53  E-value: 3.74e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469164934 105 DLDPILSAIWKGDVKALQKIIHSKSKNLYEpnkdGWLPLHESA--YYGSVK-CLKILLKAKPETIN------KQTN---K 172
Cdd:TIGR00870  52 GRSALFVAAIENENLELTELLLNLSCRGAV----GDTLLHAISleYVDAVEaILLHLLAAFRKSGPlelandQYTSeftP 127

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469164934 173 SQTPLMLAVCRKHFSCVEHLLEQGADPNLANN--------------QWETPLYKACEKANEAIVELLLRFGASPTKACAQ 238
Cdd:TIGR00870 128 GITALHLAAHRQNYEIVKLLLERGASVPARACgdffvksqgvdsfyHGESPLNAAACLGSPSIVALLSEDPADILTADSL 207

                         170
                  ....*....|....*
gi 1469164934 239 GGTPLHEAVRNKKLK 253
Cdd:TIGR00870 208 GNTLLHLLVMENEFK 222
SOCS_ASB5 cd03724
SOCS (suppressors of cytokine signaling) box of ASB5-like proteins. ASB family members have a ...
 599-637 6.90e-04

SOCS (suppressors of cytokine signaling) box of ASB5-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB5 has been implicated in the initiation of arteriogenesis. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239694  Cd Length: 42  Bit Score: 37.55  E-value: 6.90e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1469164934 599 PCTLMHLCRLKIRQRLGIQRLCHISALPLPERLIMFLNY 637
Cdd:cd03724     3 PSSLCQLCRLCIRNYIGRSRLHLIPQLQLPTLLKNFLQY 41
Ank_5 pfam13857
Ankyrin repeats (many copies);
328-377 7.32e-04

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 38.10  E-value: 7.32e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1469164934 328 SADVNITNKTGLLPIHVAAKNGHDSIVAMLIPRTSMVKVR-SSGISSLHFA 377
Cdd:pfam13857   6 PIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKdEEGLTALDLA 56
PHA02989 PHA02989
ankyrin repeat protein; Provisional
 367-469 9.98e-04

ankyrin repeat protein; Provisional


Pssm-ID: 222954 [Multi-domain]  Cd Length: 494  Bit Score: 42.04  E-value: 9.98e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469164934 367 RSSGISSLHFAAENNKDSVLEILIDAGYDVNakmsddwskmYEDHRSTALYSAVANSNIEAA------TMLLEAGADPNL 440
Cdd:PHA02989   34 RGNSILLLYLKRKDVKIKIVKLLIDNGADVN----------YKGYIETPLCAVLRNREITSNkikkivKLLLKFGADINL 103

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1469164934 441 DIFN------PLLVAVRIGSMEMVALLLKHGANVN 469
Cdd:PHA02989  104 KTFNgvspivCFIYNSNINNCDMLRFLLSKGINVN 138
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 175-201 1.59e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 36.41  E-value: 1.59e-03
                           10        20
                   ....*....|....*....|....*..
gi 1469164934  175 TPLMLAVCRKHFSCVEHLLEQGADPNL 201
Cdd:smart00248   4 TPLHLAAENGNLEVVKLLLDKGADINA 30
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 121-259 1.75e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 41.40  E-value: 1.75e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469164934 121 LQKIIHSKSKNLYEPNKDGWLPLHESAYYGSVKCLKILLKAKPETiNKQTNKSQTPLMLAVCR-KHFSCVEHLLEQGADP 199
Cdd:PHA02878  183 LTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGAST-DARDKCGNTPLHISVGYcKDYDILKLLLEHGVDV 261

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1469164934 200 NLANNQWE-TPLYKACEkaNEAIVELLLRFGASPTKACAQGGTPLHEAVRNKK-LKITKMLI 259
Cdd:PHA02878  262 NAKSYILGlTALHSSIK--SERKLKLLLEYGADINSLNSYKLTPLSSAVKQYLcINIGRILI 321
Ank_5 pfam13857
Ankyrin repeats (many copies);
192-246 2.71e-03

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 36.56  E-value: 2.71e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1469164934 192 LLEQG-ADPNLANNQWETPLYKACEKANEAIVELLLRFGASPTKACAQGGTPLHEA 246
Cdd:pfam13857   1 LLEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
SOCS_WSB_SWIP cd03733
SOCS (suppressors of cytokine signaling) box of WSB/SWiP-like proteins. This subfamily ...
 601-637 2.81e-03

SOCS (suppressors of cytokine signaling) box of WSB/SWiP-like proteins. This subfamily contains WSB-1 (SOCS-box-containing WD-40 protein), part of an E3 ubiquitin ligase for the thyroid-hormone-activating type 2 iodothyronine deiodinase (D2), and SWiP-1 (SOCS box and WD-repeats in Protein), a WD40-containing protein that is expressed in embryonic structures of chickens and regulated by Sonic Hedgehog (Shh), as well as, their isoforms WSB-2 and SWiP-2. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239702  Cd Length: 39  Bit Score: 35.86  E-value: 2.81e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1469164934 601 TLMHLCRLKIRQRLGIQRlchISALPLPERLIMFLNY 637
Cdd:cd03733     5 SLQHLCRMALRRVMTTQQ---VLALPIPKKMKEFLTY 38
SOCS_ASB6 cd03725
SOCS (suppressors of cytokine signaling) box of ASB6-like proteins. ASB family members have a ...
 599-639 4.25e-03

SOCS (suppressors of cytokine signaling) box of ASB6-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB6 interacts with the adaptor protein APS and recruits elongin B/C to the insulin receptor signaling complex. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239695  Cd Length: 44  Bit Score: 35.50  E-value: 4.25e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1469164934 599 PCTLMHLCRLKIRQRLGIQRL-CHISALPLPERLIMFLNYER 639
Cdd:cd03725     3 PPPLKHLCRVFIRLCLRPWPVdVKVKALPLPDRLKWYLLPEH 44
PHA02730 PHA02730
ankyrin-like protein; Provisional
 388-493 6.88e-03

ankyrin-like protein; Provisional


Pssm-ID: 165098 [Multi-domain]  Cd Length: 672  Bit Score: 39.62  E-value: 6.88e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469164934 388 ILIDAgYDVNAKMSDDWSkMYEDHRSTALYSAVANSNIEAATMLLEAGADPNLDIFNPLLVAVRIGS------MEMVALL 461
Cdd:PHA02730  440 ILIDV-FDILSKYMDDID-MIDNENKTLLYYAVDVNNIQFARRLLEYGASVNTTSRSIINTAIQKSSyrrenkTKLVDLL 517

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1469164934 462 LKHGANVNAMLPTHPTS----FPAALVFCLRFMLMM 493
Cdd:PHA02730  518 LSYHPTLETMIDAFNRDirylYPEPLLACIRYALIL 553
PHA02859 PHA02859
ankyrin repeat protein; Provisional
 278-438 6.89e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165195 [Multi-domain]  Cd Length: 209  Bit Score: 38.26  E-value: 6.89e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469164934 278 MAAQCNSVEVLNYLIYKGGNvntqanddasALFEACKNGHAKAVEILLSQSADVNITNKTgllPIH--VAAKNGHDSIVA 355
Cdd:PHA02859    4 LCSEYDYNDFTDYLFYRYCN----------PLFYYVEKDDIEGVKKWIKFVNDCNDLYET---PIFscLEKDKVNVEILK 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469164934 356 MLIPRTSMV--KVRSSGISSLHFAAENNKD---SVLEILIDAGYDVNAKMSDDWSKMYedhrstaLYSAVANSNIEAATM 430
Cdd:PHA02859   71 FLIENGADVnfKTRDNNLSALHHYLSFNKNvepEILKILIDSGSSITEEDEDGKNLLH-------MYMCNFNVRINVIKL 143


                  ....*...
gi 1469164934 431 LLEAGADP 438
Cdd:PHA02859  144 LIDSGVSF 151
PHA02859 PHA02859
ankyrin repeat protein; Provisional
 100-349 6.89e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165195 [Multi-domain]  Cd Length: 209  Bit Score: 38.26  E-value: 6.89e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469164934 100 VEYMNdldPILSAIWKGDVKALQKIIHSKSKN--LYEPnkdgwlPLHesayygsvKCLKillkakpetiNKQTNKSqtpl 177
Cdd:PHA02859   19 YRYCN---PLFYYVEKDDIEGVKKWIKFVNDCndLYET------PIF--------SCLE----------KDKVNVE---- 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469164934 178 mlavcrkhfsCVEHLLEQGADPNL---ANNQWETPLYKACEK-ANEAIVELLLRFGASPTKACAQGGTPLHEAVRN--KK 251
Cdd:PHA02859   68 ----------ILKFLIENGADVNFktrDNNLSALHHYLSFNKnVEPEILKILIDSGSSITEEDEDGKNLLHMYMCNfnVR 137

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469164934 252 LKITKMLIKAGAklcakNIYGIDSlfmaaQCNSVeVLNYLIYKggnvntqaNDDasalfeacknghaKAVEILLSQSADV 331
Cdd:PHA02859  138 INVIKLLIDSGV-----SFLNKDF-----DNNNI-LYSYILFH--------SDK-------------KIFDFLTSLGIDI 185

                         250
                  ....*....|....*...
gi 1469164934 332 NITNKTGLLPIHVAAKNG 349
Cdd:PHA02859  186 NETNKSGYNCYDLIKFRN 203
PHA02884 PHA02884
ankyrin repeat protein; Provisional
 409-495 7.63e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165212 [Multi-domain]  Cd Length: 300  Bit Score: 38.81  E-value: 7.63e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469164934 409 EDHRSTALYSAVANSNIEAATMLLEAGADPNL----DIFNPLLVAVRIGSMEMVALLLKHGANVNAMLPTHPTSFPAALV 484
Cdd:PHA02884   67 ENSKTNPLIYAIDCDNDDAAKLLIRYGADVNRyaeeAKITPLYISVLHGCLKCLEILLSYGADINIQTNDMVTPIELALM 146

                          90
                  ....*....|.
gi 1469164934 485 FCLRFMLMMKC 495
Cdd:PHA02884  147 ICNNFLAFMIC 157
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 443-470 7.83e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 34.49  E-value: 7.83e-03
                           10        20
                   ....*....|....*....|....*...
gi 1469164934  443 FNPLLVAVRIGSMEMVALLLKHGANVNA 470
Cdd:smart00248   3 RTPLHLAAENGNLEVVKLLLDKGADINA 30
Ank_5 pfam13857
Ankyrin repeats (many copies);
297-345 8.43e-03

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 35.01  E-value: 8.43e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1469164934 297 NVNTQANDDASALFEACKNGHAKAVEILLSQSADVNITNKTGLLPIHVA 345
Cdd:pfam13857   8 DLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
SOCS_WSB1_SWIP1 cd03746
SOCS (suppressors of cytokine signaling) box of WSB1/SWiP1-like proteins. This subfamily ...
 601-638 9.12e-03

SOCS (suppressors of cytokine signaling) box of WSB1/SWiP1-like proteins. This subfamily contains WSB-1 (SOCS-box-containing WD-40 protein), part of an E3 ubiquitin ligase for the thyroid-hormone-activating type 2 iodothyronine deiodinase (D2) and SWiP-1 (SOCS box and WD-repeats in Protein), a WD40-containing protein that is expressed in embryonic structures of chickens and regulated by Sonic Hedgehog (Shh). The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239715  Cd Length: 40  Bit Score: 34.40  E-value: 9.12e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1469164934 601 TLMHLCRLKIRQRLGIQRlchISALPLPERLIMFLNYE 638
Cdd:cd03746     5 SLQHLCRMAIRRVMPTQQ---VKELPIPSKLLEFLTYR 39
PHA02989 PHA02989
ankyrin repeat protein; Provisional
 241-353 9.56e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222954 [Multi-domain]  Cd Length: 494  Bit Score: 38.95  E-value: 9.56e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469164934 241 TPLHEAVRNKKL------KITKMLIKAGAKLCAKNIYGIDSL--FM-AAQCNSVEVLNYLIYKGGNVNTQANDDASAL-- 309
Cdd:PHA02989   71 TPLCAVLRNREItsnkikKIVKLLLKFGADINLKTFNGVSPIvcFIyNSNINNCDMLRFLLSKGINVNDVKNSRGYNLlh 150

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1469164934 310 --FEACkNGHAKAVEILLsqSADVNITNKT---GLLPIHVAAKNGHDSI 353
Cdd:PHA02989  151 myLESF-SVKKDVIKILL--SFGVNLFEKTslyGLTPMNIYLRNDIDVI 196
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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