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Conserved domains on  [gi|1604798670|ref|XP_028462223|]
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Fc receptor-like B [Perca flavescens]

Protein Classification

immunoglobulin domain-containing protein( domain architecture ID 12208729)

immunoglobulin (Ig) domain-containing protein adopts a fold comprised of a sandwich of two beta sheets and may function in cell adhesion and/or pattern recognition

CATH:  2.60.40.10
PubMed:  7932691|10436082

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 118-179 1.13e-05

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


:

Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 42.49  E-value: 1.13e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1604798670  118 SPVLPVMEGEDLTLTCKTKTPSNLPAGFYKDGV----------FIGNEHEGHMTIHHVSRSDEGLYKCLISS 179
Cdd:smart00410   1 PPSVTVKEGESVTLSCEASGSPPPEVTWYKQGGkllaesgrfsVSRSGSTSTLTISNVTPEDSGTYTCAATN 72
 
Name Accession Description Interval E-value
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 118-179 1.13e-05

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 42.49  E-value: 1.13e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1604798670  118 SPVLPVMEGEDLTLTCKTKTPSNLPAGFYKDGV----------FIGNEHEGHMTIHHVSRSDEGLYKCLISS 179
Cdd:smart00410   1 PPSVTVKEGESVTLSCEASGSPPPEVTWYKQGGkllaesgrfsVSRSGSTSTLTISNVTPEDSGTYTCAATN 72
Ig2_FcgammaR_like cd05753
Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains; ...
 115-175 8.13e-05

Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains; The members here are composed of the second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs). Interactions between IgG and FcgammaR are important to the initiation of cellular and humoral response. IgG binding to FcgammaR leads to a cascade of signals and ultimately to functions such as antibody-dependent-cellular-cytotoxicity (ADCC), endocytosis, phagocytosis, release of inflammatory mediators, etc. FcgammaR has two Ig-like domains. This group also contains FcepsilonRI which binds IgE with high affinity.


Pssm-ID: 409411  Cd Length: 83  Bit Score: 39.98  E-value: 8.13e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1604798670 115 ILQSPVLPVMEGEDLTLTCKTKTPSNLPA-GFYKDGVFIGNEHEGH-MTIHHVSRSDEGLYKC 175
Cdd:cd05753     3 LLQAPSAVVFEGEPLTLRCHGWKDKKVHKvTYYKDGKALKFSYENSnFSIPQATLSDSGSYHC 65
Ig_2 pfam13895
Immunoglobulin domain; This domain contains immunoglobulin-like domains.
 115-175 1.51e-04

Immunoglobulin domain; This domain contains immunoglobulin-like domains.


Pssm-ID: 464026 [Multi-domain]  Cd Length: 79  Bit Score: 39.30  E-value: 1.51e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1604798670 115 ILQSPVLPVMEGEDLTLTCktKTPSNLPAGF--YKDGVFIGNEHEghMTIHHVSRSDEGLYKC 175
Cdd:pfam13895   3 VLTPSPTVVTEGEPVTLTC--SAPGNPPPSYtwYKDGSAISSSPN--FFTLSVSAEDSGTYTC 61
 
Name Accession Description Interval E-value
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 118-179 1.13e-05

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 42.49  E-value: 1.13e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1604798670  118 SPVLPVMEGEDLTLTCKTKTPSNLPAGFYKDGV----------FIGNEHEGHMTIHHVSRSDEGLYKCLISS 179
Cdd:smart00410   1 PPSVTVKEGESVTLSCEASGSPPPEVTWYKQGGkllaesgrfsVSRSGSTSTLTISNVTPEDSGTYTCAATN 72
Ig2_FcgammaR_like cd05753
Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains; ...
 115-175 8.13e-05

Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains; The members here are composed of the second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs). Interactions between IgG and FcgammaR are important to the initiation of cellular and humoral response. IgG binding to FcgammaR leads to a cascade of signals and ultimately to functions such as antibody-dependent-cellular-cytotoxicity (ADCC), endocytosis, phagocytosis, release of inflammatory mediators, etc. FcgammaR has two Ig-like domains. This group also contains FcepsilonRI which binds IgE with high affinity.


Pssm-ID: 409411  Cd Length: 83  Bit Score: 39.98  E-value: 8.13e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1604798670 115 ILQSPVLPVMEGEDLTLTCKTKTPSNLPA-GFYKDGVFIGNEHEGH-MTIHHVSRSDEGLYKC 175
Cdd:cd05753     3 LLQAPSAVVFEGEPLTLRCHGWKDKKVHKvTYYKDGKALKFSYENSnFSIPQATLSDSGSYHC 65
Ig_2 pfam13895
Immunoglobulin domain; This domain contains immunoglobulin-like domains.
 115-175 1.51e-04

Immunoglobulin domain; This domain contains immunoglobulin-like domains.


Pssm-ID: 464026 [Multi-domain]  Cd Length: 79  Bit Score: 39.30  E-value: 1.51e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1604798670 115 ILQSPVLPVMEGEDLTLTCktKTPSNLPAGF--YKDGVFIGNEHEghMTIHHVSRSDEGLYKC 175
Cdd:pfam13895   3 VLTPSPTVVTEGEPVTLTC--SAPGNPPPSYtwYKDGSAISSSPN--FFTLSVSAEDSGTYTC 61
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 113-178 3.94e-04

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 37.93  E-value: 3.94e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1604798670 113 PVILQSP-VLPVMEGEDLTLTCKTKTPSnlPAGF--YKDGVFIGNEH---------EGHMTIHHVSRSDEGLYKCLIS 178
Cdd:pfam13927   2 PVITVSPsSVTVREGETVTLTCEATGSP--PPTItwYKNGEPISSGStrsrslsgsNSTLTISNVTRSDAGTYTCVAS 77
I-set pfam07679
Immunoglobulin I-set domain;
113-175 1.15e-03

Immunoglobulin I-set domain;


Pssm-ID: 400151 [Multi-domain]  Cd Length: 90  Bit Score: 36.85  E-value: 1.15e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1604798670 113 PVILQSPV-LPVMEGEDLTLTCKTK---TPSnlpAGFYKDGVFIGNEHEGHM---------TIHHVSRSDEGLYKC 175
Cdd:pfam07679   1 PKFTQKPKdVEVQEGESARFTCTVTgtpDPE---VSWFKDGQPLRSSDRFKVtyeggtytlTISNVQPDDSGKYTC 73
IgV_1_Necl_like cd05717
First (N-terminal) immunoglobulin (Ig)-like domain of the nectin-like molecules; member of the ...
 123-191 2.90e-03

First (N-terminal) immunoglobulin (Ig)-like domain of the nectin-like molecules; member of the V-set of Ig superfamily (IgSF) domains; The members here are composed of the N-terminal immunoglobulin (Ig)-like domain of the nectin-like molecules Necl-1 (also known as cell adhesion molecule 3 (CADM3)), Necl-2 (CADM1), Necl-3 (CADM2), and similar proteins. At least five nectin-like molecules have been identified (Necl-1 to Necl-5). They all have an extracellular region containing three Ig-like domains, a transmembrane region, and a cytoplasmic region. The N-terminal Ig-like domain of the extracellular region belongs to the V-type subfamily of Ig domains, is essential to cell-cell adhesion, and plays a part in the interaction with the envelope glycoprotein D of various viruses. Necl-1, Necl-2, and Necl-3 have Ca(2+)-independent homophilic and heterophilic cell-cell adhesion activity. Necl-1 is specifically expressed in neural tissue, and is important to the formation of synapses, axon bundles, and myelinated axons. Necl-2 is expressed in a wide variety of tissues and is a putative tumour suppressor gene which is downregulated in aggressive neuroblastoma. Necl-3 accumulates in central and peripheral nervous system tissue and has been shown to selectively interact with oligodendrocytes. This group also contains Class-I MHC-restricted T-cell-associated molecule (CRTAM), whose expression pattern is consistent with its expression in Class-I MHC-restricted T-cells.


Pssm-ID: 409382  Cd Length: 94  Bit Score: 35.95  E-value: 2.90e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1604798670 123 VMEGEDLTLTCKTKTPSNL------PAGF---------YKDGVF---IGNEHEGHMTIHHVSRSDEGLYKCLISSvveSP 184
Cdd:cd05717     8 VVEGETLTLKCQVSLRDDSslqwlnPNGQtiyfndkraLRDSRYqllNHSASELSISVSNVTLSDEGVYTCLHYT---DP 84


                  ....*..
gi 1604798670 185 PSWVSVT 191
Cdd:cd05717    85 VSTKKVT 91
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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