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Conserved domains on  [gi|1624714079|ref|XP_028872411|]
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Nucleoside diphosphate kinase [Babesia sp. Xinjiang]

Protein Classification

nucleoside-diphosphate kinase( domain architecture ID 1539)

nucleoside-diphosphate kinase catalyzes the exchange of phosphate groups between different nucleoside diphosphates

CATH:  3.30.70.141
EC:  2.7.4.6
Gene Ontology:  GO:0006241|GO:0004550|GO:0046872|GO:0005524|GO:0006228|GO:0006183

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NDPk super family cl00335
Nucleoside diphosphate kinases (NDP kinases, NDPks): NDP kinases, responsible for the ...
 3-150 7.33e-89

Nucleoside diphosphate kinases (NDP kinases, NDPks): NDP kinases, responsible for the synthesis of nucleoside triphosphates (NTPs), are involved in numerous regulatory processes associated with proliferation, development, and differentiation. They are vital for DNA/RNA synthesis, cell division, macromolecular metabolism and growth. The enzymes generate NTPs or their deoxy derivatives by terminal (gamma) phosphotransfer from an NTP such as ATP or GTP to any nucleoside diphosphate (NDP) or its deoxy derivative. The sequence of NDPk has been highly conserved through evolution. There is a single histidine residue conserved in all known NDK isozymes, which is involved in the catalytic mechanism. The first confirmed metastasis suppressor gene was the NDP kinase protein encoded by the nm23 gene. Unicellular organisms generally possess only one gene encoding NDP kinase, while most multicellular organisms possess not only an ortholog that provides most of the NDP kinase enzymatic activity but also multiple divergent paralogous genes. The human genome codes for at least nine NDP kinases and can be classified into two groups, Groups I and II, according to their genomic architecture and distinct enzymatic activity. Group I isoforms (A-D) are well-conserved, catalytically active, and share 58-88% identity between each other, while Group II are more divergent, with only NDPk6 shown to be active. NDP kinases exist in two different quaternary structures; all known eukaryotic enzymes are hexamers, while some bacterial enzymes are tetramers, as in Myxococcus. The hexamer can be viewed as trimer of dimers, while tetramers are dimers of dimers, with the dimerization interface conserved.


The actual alignment was detected with superfamily member PTZ00093:

Pssm-ID: 469726  Cd Length: 149  Bit Score: 255.42  E-value: 7.33e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624714079   3 VERTYIMVKPDGVQRGIIGEVLKRYEQRGLKLVAAKFCKPSEQVVAEHYVEHREKPFFSELCDFIGQGPVFCMIWEGPEA 82
Cdd:PTZ00093    2 SERTFIMVKPDGVQRGLVGEIIKRFEKKGYKLVALKMLQPTPEIAEEHYKEHKGKPFFPGLVKYISSGPVVCMVWEGKNV 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1624714079  83 VKIGRKVVGVTSPLESDAGTIRGDFGVVTHLNLVHASSSIEDAERECHLWFKPEEIVSWDRSVGSWIY 150
Cdd:PTZ00093   82 VKQGRKLLGATNPLESAPGTIRGDFCVDVGRNVIHGSDSVESAKREIALWFKPEELVSWTSHSSKWIY 149
 
Name Accession Description Interval E-value
PTZ00093 PTZ00093
nucleoside diphosphate kinase, cytosolic; Provisional
 3-150 7.33e-89

nucleoside diphosphate kinase, cytosolic; Provisional


Pssm-ID: 173387  Cd Length: 149  Bit Score: 255.42  E-value: 7.33e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624714079   3 VERTYIMVKPDGVQRGIIGEVLKRYEQRGLKLVAAKFCKPSEQVVAEHYVEHREKPFFSELCDFIGQGPVFCMIWEGPEA 82
Cdd:PTZ00093    2 SERTFIMVKPDGVQRGLVGEIIKRFEKKGYKLVALKMLQPTPEIAEEHYKEHKGKPFFPGLVKYISSGPVVCMVWEGKNV 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1624714079  83 VKIGRKVVGVTSPLESDAGTIRGDFGVVTHLNLVHASSSIEDAERECHLWFKPEEIVSWDRSVGSWIY 150
Cdd:PTZ00093   82 VKQGRKLLGATNPLESAPGTIRGDFCVDVGRNVIHGSDSVESAKREIALWFKPEELVSWTSHSSKWIY 149
Ndk COG0105
Nucleoside diphosphate kinase [Nucleotide transport and metabolism]; Nucleoside diphosphate ...
 2-141 4.94e-74

Nucleoside diphosphate kinase [Nucleotide transport and metabolism]; Nucleoside diphosphate kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 439875  Cd Length: 140  Bit Score: 217.24  E-value: 4.94e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624714079   2 KVERTYIMVKPDGVQRGIIGEVLKRYEQRGLKLVAAKFCKPSEQVVAEHYVEHREKPFFSELCDFIGQGPVFCMIWEGPE 81
Cdd:COG0105     1 AMERTLVIIKPDAVQRGLIGEIISRFERKGLKIVALKMLQLTREQAEEHYAEHKGKPFFGELVEFMTSGPVVAMVLEGEN 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624714079  82 AVKIGRKVVGVTSPLESDAGTIRGDFGVVTHLNLVHASSSIEDAERECHLWFKPEEIVSW 141
Cdd:COG0105    81 AVAVVRKLMGATNPAEAAPGTIRGDFALSIGENAVHGSDSPESAEREIALFFSEEEIVSY 140
NDK pfam00334
Nucleoside diphosphate kinase;
4-138 5.56e-73

Nucleoside diphosphate kinase;


Pssm-ID: 459766  Cd Length: 135  Bit Score: 214.66  E-value: 5.56e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624714079   4 ERTYIMVKPDGVQRGIIGEVLKRYEQRGLKLVAAKFCKPSEQVVAEHYVEHREKPFFSELCDFIGQGPVFCMIWEGPEAV 83
Cdd:pfam00334   1 ERTLAIIKPDAVQRGLIGEIISRFERKGFKIVALKMLQLTREQAEEHYAEHKGKPFFPDLVEFMTSGPVVAMVLEGENAI 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1624714079  84 KIGRKVVGVTSPLESDAGTIRGDFGVVTHLNLVHASSSIEDAERECHLWFKPEEI 138
Cdd:pfam00334  81 SKWRELMGATNPAEAAPGTIRGDFAVSIGRNAVHGSDSPESAEREIALFFPEEEI 135
NDPk_I cd04413
Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large ...
 4-133 4.67e-72

Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside triphosphate (NTP) donor onto a nucleoside diphosphate (NDP) acceptor through a phosphohistidine intermediate. The mammalian nm23/NDP kinase gene family can be divided into two distinct groups. The group I genes encode proteins that generally have highly homologous counterparts in other organisms and possess the classic enzymatic activity of a kinase. This group includes vertebrate NDP kinases A-D (Nm23- H1 to -H4), and its counterparts in bacteria, archea and other eukaryotes. NDP kinases exist in two different quaternary structures; all known eukaryotic enzymes are hexamers, while some bacterial enzymes are tetramers, as in Myxococcus. They possess the NDP kinase active site motif (NXXH[G/A]SD) and the nine residues that are most essential for catalysis.


Pssm-ID: 239876  Cd Length: 130  Bit Score: 211.94  E-value: 4.67e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624714079   4 ERTYIMVKPDGVQRGIIGEVLKRYEQRGLKLVAAKFCKPSEQVVAEHYVEHREKPFFSELCDFIGQGPVFCMIWEGPEAV 83
Cdd:cd04413     1 ERTLVIIKPDGVQRGLIGEIISRFERKGLKIVALKMLQLTEELAEEHYAEHKGKPFFPELVEFMTSGPVVAMVLEGENAV 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1624714079  84 KIGRKVVGVTSPLESDAGTIRGDFGVVTHLNLVHASSSIEDAERECHLWF 133
Cdd:cd04413    81 KTVRKLMGATNPADAAPGTIRGDFALSIGRNIVHGSDSVESAEREIALWF 130
NDK smart00562
Enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to ...
 4-138 7.06e-63

Enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to nucleoside triphosphates; These enzymes play important roles in bacterial growth, signal transduction and pathogenicity.


Pssm-ID: 197791  Cd Length: 135  Bit Score: 188.91  E-value: 7.06e-63
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624714079    4 ERTYIMVKPDGVQRGIIGEVLKRYEQRGLKLVAAKFCKPSEQVVAEHYVEHREKPFFSELCDFIGQGPVFCMIWEGPEAV 83
Cdd:smart00562   1 ERTLAIIKPDAVQRGLIGEIISRFERKGFKIVAMKMLQLTEEQAEEFYAEHEGKPFFNDLVEFMTSGPVVAMVLEGEDAV 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1624714079   84 KIGRKVVGVTSPLESDAGTIRGDFGVVTHLNLVHASSSIEDAERECHLWFKPEEI 138
Cdd:smart00562  81 KTWRTLMGPTDPREAAPGTIRGDFGLDIGRNAVHGSDSPESAEREIALFFPESEI 135
 
Name Accession Description Interval E-value
PTZ00093 PTZ00093
nucleoside diphosphate kinase, cytosolic; Provisional
 3-150 7.33e-89

nucleoside diphosphate kinase, cytosolic; Provisional


Pssm-ID: 173387  Cd Length: 149  Bit Score: 255.42  E-value: 7.33e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624714079   3 VERTYIMVKPDGVQRGIIGEVLKRYEQRGLKLVAAKFCKPSEQVVAEHYVEHREKPFFSELCDFIGQGPVFCMIWEGPEA 82
Cdd:PTZ00093    2 SERTFIMVKPDGVQRGLVGEIIKRFEKKGYKLVALKMLQPTPEIAEEHYKEHKGKPFFPGLVKYISSGPVVCMVWEGKNV 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1624714079  83 VKIGRKVVGVTSPLESDAGTIRGDFGVVTHLNLVHASSSIEDAERECHLWFKPEEIVSWDRSVGSWIY 150
Cdd:PTZ00093   82 VKQGRKLLGATNPLESAPGTIRGDFCVDVGRNVIHGSDSVESAKREIALWFKPEELVSWTSHSSKWIY 149
Ndk COG0105
Nucleoside diphosphate kinase [Nucleotide transport and metabolism]; Nucleoside diphosphate ...
 2-141 4.94e-74

Nucleoside diphosphate kinase [Nucleotide transport and metabolism]; Nucleoside diphosphate kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 439875  Cd Length: 140  Bit Score: 217.24  E-value: 4.94e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624714079   2 KVERTYIMVKPDGVQRGIIGEVLKRYEQRGLKLVAAKFCKPSEQVVAEHYVEHREKPFFSELCDFIGQGPVFCMIWEGPE 81
Cdd:COG0105     1 AMERTLVIIKPDAVQRGLIGEIISRFERKGLKIVALKMLQLTREQAEEHYAEHKGKPFFGELVEFMTSGPVVAMVLEGEN 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624714079  82 AVKIGRKVVGVTSPLESDAGTIRGDFGVVTHLNLVHASSSIEDAERECHLWFKPEEIVSW 141
Cdd:COG0105    81 AVAVVRKLMGATNPAEAAPGTIRGDFALSIGENAVHGSDSPESAEREIALFFSEEEIVSY 140
NDK pfam00334
Nucleoside diphosphate kinase;
4-138 5.56e-73

Nucleoside diphosphate kinase;


Pssm-ID: 459766  Cd Length: 135  Bit Score: 214.66  E-value: 5.56e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624714079   4 ERTYIMVKPDGVQRGIIGEVLKRYEQRGLKLVAAKFCKPSEQVVAEHYVEHREKPFFSELCDFIGQGPVFCMIWEGPEAV 83
Cdd:pfam00334   1 ERTLAIIKPDAVQRGLIGEIISRFERKGFKIVALKMLQLTREQAEEHYAEHKGKPFFPDLVEFMTSGPVVAMVLEGENAI 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1624714079  84 KIGRKVVGVTSPLESDAGTIRGDFGVVTHLNLVHASSSIEDAERECHLWFKPEEI 138
Cdd:pfam00334  81 SKWRELMGATNPAEAAPGTIRGDFAVSIGRNAVHGSDSPESAEREIALFFPEEEI 135
NDPk_I cd04413
Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large ...
 4-133 4.67e-72

Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside triphosphate (NTP) donor onto a nucleoside diphosphate (NDP) acceptor through a phosphohistidine intermediate. The mammalian nm23/NDP kinase gene family can be divided into two distinct groups. The group I genes encode proteins that generally have highly homologous counterparts in other organisms and possess the classic enzymatic activity of a kinase. This group includes vertebrate NDP kinases A-D (Nm23- H1 to -H4), and its counterparts in bacteria, archea and other eukaryotes. NDP kinases exist in two different quaternary structures; all known eukaryotic enzymes are hexamers, while some bacterial enzymes are tetramers, as in Myxococcus. They possess the NDP kinase active site motif (NXXH[G/A]SD) and the nine residues that are most essential for catalysis.


Pssm-ID: 239876  Cd Length: 130  Bit Score: 211.94  E-value: 4.67e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624714079   4 ERTYIMVKPDGVQRGIIGEVLKRYEQRGLKLVAAKFCKPSEQVVAEHYVEHREKPFFSELCDFIGQGPVFCMIWEGPEAV 83
Cdd:cd04413     1 ERTLVIIKPDGVQRGLIGEIISRFERKGLKIVALKMLQLTEELAEEHYAEHKGKPFFPELVEFMTSGPVVAMVLEGENAV 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1624714079  84 KIGRKVVGVTSPLESDAGTIRGDFGVVTHLNLVHASSSIEDAERECHLWF 133
Cdd:cd04413    81 KTVRKLMGATNPADAAPGTIRGDFALSIGRNIVHGSDSVESAEREIALWF 130
ndk PRK00668
mulitfunctional nucleoside diphosphate kinase/apyrimidinic endonuclease/3'-; Validated
 3-136 9.56e-70

mulitfunctional nucleoside diphosphate kinase/apyrimidinic endonuclease/3'-; Validated


Pssm-ID: 179085  Cd Length: 134  Bit Score: 206.50  E-value: 9.56e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624714079   3 VERTYIMVKPDGVQRGIIGEVLKRYEQRGLKLVAAKFCKPSEQVVAEHYVEHREKPFFSELCDFIGQGPVFCMIWEGPEA 82
Cdd:PRK00668    1 MERTFSIIKPDAVQRGLIGEIISRFEKKGLKIVALKMMQLSRELAEGHYAEHKEKPFFGELVEFMTSGPVVVMVLEGENA 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1624714079  83 VKIGRKVVGVTSPLESDAGTIRGDFGVVTHLNLVHASSSIEDAERECHLWFKPE 136
Cdd:PRK00668   81 IAKVRELMGATNPAEAAPGTIRGDFALSIGENVVHGSDSPESAAREIALFFSEE 134
NDK smart00562
Enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to ...
 4-138 7.06e-63

Enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to nucleoside triphosphates; These enzymes play important roles in bacterial growth, signal transduction and pathogenicity.


Pssm-ID: 197791  Cd Length: 135  Bit Score: 188.91  E-value: 7.06e-63
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624714079    4 ERTYIMVKPDGVQRGIIGEVLKRYEQRGLKLVAAKFCKPSEQVVAEHYVEHREKPFFSELCDFIGQGPVFCMIWEGPEAV 83
Cdd:smart00562   1 ERTLAIIKPDAVQRGLIGEIISRFERKGFKIVAMKMLQLTEEQAEEFYAEHEGKPFFNDLVEFMTSGPVVAMVLEGEDAV 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1624714079   84 KIGRKVVGVTSPLESDAGTIRGDFGVVTHLNLVHASSSIEDAERECHLWFKPEEI 138
Cdd:smart00562  81 KTWRTLMGPTDPREAAPGTIRGDFGLDIGRNAVHGSDSPESAEREIALFFPESEI 135
PLN02619 PLN02619
nucleoside-diphosphate kinase
 2-150 3.39e-61

nucleoside-diphosphate kinase


Pssm-ID: 178228  Cd Length: 238  Bit Score: 188.52  E-value: 3.39e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624714079   2 KVERTYIMVKPDGVQRGIIGEVLKRYEQRGLKLVAAKFCKPSEQVVAEHYVEHREKPFFSELCDFIGQGPVFCMIWEGPE 81
Cdd:PLN02619   87 EMERTFIAIKPDGVQRGLISEIISRFERKGFKLVAIKVVVPSKEFAQKHYHDLKERPFFNGLCDFLSSGPVVAMVWEGEG 166

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1624714079  82 AVKIGRKVVGVTSPLESDAGTIRGDFGVVTHLNLVHASSSIEDAERECHLWFKPEEIVSWDRSVGSWIY 150
Cdd:PLN02619  167 VIKYGRKLIGATDPQKSEPGTIRGDLAVVVGRNIIHGSDGPETAKDEINLWFKPEELVSYTSNAEKWIY 235
PRK14540 PRK14540
nucleoside diphosphate kinase; Provisional
 3-134 3.50e-42

nucleoside diphosphate kinase; Provisional


Pssm-ID: 184733  Cd Length: 134  Bit Score: 136.49  E-value: 3.50e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624714079   3 VERTYIMVKPDGVQRGIIGEVLKRYEQRGLKLVAAKFCKPSEQVVAEHYVEHREKPFFSELCDFIGQGPVFCMIWEGPEA 82
Cdd:PRK14540    2 KERTFVALKPDAVERKLIGKIIQRFENKGFEIVEMKMLKLTREMAEEYYEEHKGKEFYERLINFMTSGRIVAMVIEGENA 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1624714079  83 VKIGRKVVGVTSPLESDAGTIRGDFGVVTHLNLVHASSSIEDAERECHLWFK 134
Cdd:PRK14540   82 ISTVRKMIGKTNPAEAEPGTIRGDFGLYTPANIIHASDSKESAEREIKLFFG 133
NDPk cd00595
Nucleoside diphosphate kinases (NDP kinases, NDPks): NDP kinases, responsible for the ...
 4-133 1.08e-41

Nucleoside diphosphate kinases (NDP kinases, NDPks): NDP kinases, responsible for the synthesis of nucleoside triphosphates (NTPs), are involved in numerous regulatory processes associated with proliferation, development, and differentiation. They are vital for DNA/RNA synthesis, cell division, macromolecular metabolism and growth. The enzymes generate NTPs or their deoxy derivatives by terminal (gamma) phosphotransfer from an NTP such as ATP or GTP to any nucleoside diphosphate (NDP) or its deoxy derivative. The sequence of NDPk has been highly conserved through evolution. There is a single histidine residue conserved in all known NDK isozymes, which is involved in the catalytic mechanism. The first confirmed metastasis suppressor gene was the NDP kinase protein encoded by the nm23 gene. Unicellular organisms generally possess only one gene encoding NDP kinase, while most multicellular organisms possess not only an ortholog that provides most of the NDP kinase enzymatic activity but also multiple divergent paralogous genes. The human genome codes for at least nine NDP kinases and can be classified into two groups, Groups I and II, according to their genomic architecture and distinct enzymatic activity. Group I isoforms (A-D) are well-conserved, catalytically active, and share 58-88% identity between each other, while Group II are more divergent, with only NDPk6 shown to be active. NDP kinases exist in two different quaternary structures; all known eukaryotic enzymes are hexamers, while some bacterial enzymes are tetramers, as in Myxococcus. The hexamer can be viewed as trimer of dimers, while tetramers are dimers of dimers, with the dimerization interface conserved.


Pssm-ID: 238335  Cd Length: 133  Bit Score: 135.17  E-value: 1.08e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624714079   4 ERTYIMVKPDGVQRGIIGEVLKRYEQRGLKLVAAKFCKPSEQVVAEHYVEHREKPFFSELCDFIGQGPVFCMIWEGPEAV 83
Cdd:cd00595     1 ERTLALIKPDAVAEGLLGEIIMRIEDAGFEIVAMKELHLTEEQAEEFYVEHKGRPFFPDLVQFMSSGPVVAMILEKDNAV 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1624714079  84 KIGRKVVGVTSPLESDA---GTIRGDFGVVTHLNLVHASSSIEDAERECHLWF 133
Cdd:cd00595    81 GEWREMLGPTNPEIARHlapGSLRADFGTDVLRNAVHGSDSVESAAREIAFFF 133
PRK14543 PRK14543
nucleoside diphosphate kinase; Provisional
 1-143 6.58e-36

nucleoside diphosphate kinase; Provisional


Pssm-ID: 237749  Cd Length: 169  Bit Score: 121.92  E-value: 6.58e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624714079   1 MKVERTYIMVKPDGVQRGIIGEVLKRYEQRGLKLVAAKFCKPSEQVVAEHY------VEHREKPFFSeLCDFIGQGPVFC 74
Cdd:PRK14543    3 TLIQKTLCIIKPDGVRRGLIGNVVSRFERVGLKIVAAKMLLVDRSMAEKHYlyddiaVRHGEAVWKS-LIKFISSSPVFV 81

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1624714079  75 MIWEGPEAVKIGRKVVGVTSPLESDAGTIRGDFGV----------VTHLNLVHASSSIEDAERECHLWFKPEEIVSWDR 143
Cdd:PRK14543   82 FVVEGVESVEVVRKFCGSTEPKLAIPGTIRGDFSYhsfnyanekgFSVYNVIHASANEDDALREIPIWFKDNEILTYKR 160
PRK14544 PRK14544
nucleoside diphosphate kinase; Provisional
 1-139 4.11e-34

nucleoside diphosphate kinase; Provisional


Pssm-ID: 173010 [Multi-domain]  Cd Length: 183  Bit Score: 117.61  E-value: 4.11e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624714079   1 MKVERTYIMVKPDGVQRGIIGEVLKRYEQRGLKLVAAKFCKPSEQVVAEHYVEHRE------------------------ 56
Cdd:PRK14544    1 MPIERTLVILKPDAVKRGLVGEIISRFEKAGLKIVAMKMVKATPEQIERFYPSSEEwyrsvgnkllkayqelgidprarl 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624714079  57 ---------KPFFSELCDFIGQGPVFCMIWEGPEAVKIGRKVVGVTSPLESDAGTIRGDFGVVTH----------LNLVH 117
Cdd:PRK14544   81 gtddpvevgKKVKESLVKYMTSGPIVAMVLKGNRAVEVVRKLVGPTSPHKAPPGTIRGDYSIDSPdlaaeegrvvYNLVH 160

                         170       180
                  ....*....|....*....|..
gi 1624714079 118 ASSSIEDAERECHLWFKPEEIV 139
Cdd:PRK14544  161 ASDSPEEAEREIKFWFREEEIL 182
PRK14542 PRK14542
nucleoside diphosphate kinase; Provisional
 3-138 1.29e-33

nucleoside diphosphate kinase; Provisional


Pssm-ID: 173008 [Multi-domain]  Cd Length: 137  Bit Score: 115.15  E-value: 1.29e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624714079   3 VERTYIMVKPDGVQRGIIGEVLKRYEQRGLKLVAAKFCKPSEQVVAEHYVEHREKPFFSELCDFIGQGPVFCMIWEGPEA 82
Cdd:PRK14542    1 MSRTFIMIKPDGVKNKHVGNILQRIEKEGFKILGLKYLKLSLEDAKQFYKVHSARPFYNDLCNYMSSGPIVAAALERDNA 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1624714079  83 VKIGRKVVGVTSPLESDAGTIRGDFGVVTHLNLVHASSSIEDAERECHLWFKPEEI 138
Cdd:PRK14542   81 VLHWREVIGATDPKEAAAGTIRALYAESKEANAVHGSDSDANAALEISFFFKGNEL 136
PRK14541 PRK14541
nucleoside diphosphate kinase; Provisional
 3-139 1.33e-33

nucleoside diphosphate kinase; Provisional


Pssm-ID: 173007  Cd Length: 140  Bit Score: 115.04  E-value: 1.33e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624714079   3 VERTYIMVKPDGVQRGIIGEVLKRYEQRGLKLVAAKFCKPSEQVVAEHYVEHREKPFFSELCDFIGQGPVFCMIWEGPEA 82
Cdd:PRK14541    1 MERTLTILKPDCVRKQLIGAVIDKIERAGFRVVAMKKTRLTKETAGEFYAVHRERPFYGELVEFMSSGPCVPMILEKENA 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1624714079  83 VKIGRKVVGVTSPLESDAGTIRGDFGVVTHLNLVHASSSIEDAERECHLWFKPEEIV 139
Cdd:PRK14541   81 VADFRTLIGATDPAEAAEGTVRKLYADSKGENIVHGSDSAENAAIEAGFFFSAEEVV 137
PRK14545 PRK14545
nucleoside diphosphate kinase; Provisional
 1-137 2.08e-30

nucleoside diphosphate kinase; Provisional


Pssm-ID: 184734  Cd Length: 139  Bit Score: 106.91  E-value: 2.08e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624714079   1 MKVERTYIMVKPDGVQRGIIGEVLKRYEQRGLKLVAAKFCKPSEQVVAEHYVEHREKPFFSELCDFIGQGPVFCMIWEGP 80
Cdd:PRK14545    1 MAGNRTFTMIKPDAVENGHIGGILDMITAAGFRIVAMKLTQLTVADAETFYAVHAERPFYGELVEFMSRGPIVAAILEKE 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1624714079  81 EAVKIGRKVVGVTSPLESDAGTIRGDFGVVTHLNLVHASSSIEDAERECHLWFKPEE 137
Cdd:PRK14545   81 NAVEDFRTLIGATNPADAAEGTIRKKYAKSIGENAVHGSDSDENAQIEGAFHFAGRE 137
NDPk7A cd04415
Nucleoside diphosphate kinase 7 domain A (NDPk7A): The nm23-H7 class of nucleoside diphosphate ...
 4-133 1.20e-23

Nucleoside diphosphate kinase 7 domain A (NDPk7A): The nm23-H7 class of nucleoside diphosphate kinase (NDPk7) consists of an N-terminal DM10 domain and two functional catalytic NDPk modules, NDPk7A and NDPk7B. The function of the DM10 domain, which also occurs in multiple copies in other proteins, is unknown. NDPk7 is predominantly expressed in testes, although appreciable amount are also found in liver, heart, brain, ovary, small intestine and spleen. The nm23-H7 gene is located in or near the hereditary prostrate cancer susceptibility locus. Nm23-H7 may be involved in the development of colon and gastric carcinoma, the latter possibly in a type-specific manner.


Pssm-ID: 239878  Cd Length: 131  Bit Score: 89.43  E-value: 1.20e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624714079   4 ERTYIMVKPDGVQRgiIGEVLKRYEQRGLKLVAAKFCKPSEQVVAEHYVEHREKPFFSELCDFIGQGPVFCMIWEGPEAV 83
Cdd:cd04415     1 EKTLALIKPDAYSK--IGKIIQIIEDAGFTITKAKMTKLSRKEAQDFYAEHQSKPFYNELVQFMTSGPIVAMELVGDDAI 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1624714079  84 KIGRKVVGVTSPL--ESDA-GTIRGDFGVVTHLNLVHASSSIEDAERECHLWF 133
Cdd:cd04415    79 SEWRKLLGPTNSSvaRSDApNSIRALFGTDGTRNAAHGSDSVASAARELEFFF 131
PLN02931 PLN02931
nucleoside diphosphate kinase family protein
 4-140 3.49e-17

nucleoside diphosphate kinase family protein


Pssm-ID: 215503  Cd Length: 177  Bit Score: 73.71  E-value: 3.49e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624714079   4 ERTYIMVKPDGVQRGIIGEVLKRYEQRGLKLVAAKFCKPSEQVVAEHYVEHREKPFFSELCDFIGQGPVFCMIWEGPEAV 83
Cdd:PLN02931   30 ERTLAMIKPDGLSGNYTERIKEVILESGFSIVKEMTTQLDEDRASLFYAEHSSRSFFPSLVKYMTSGPVLVMVLEKENAV 109

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624714079  84 KIGRKVVGVTSPLE---SDAGTIRGDFGVVTHLNLVHASSSIEDAERECHLWFkpEEIVS 140
Cdd:PLN02931  110 SDWRTLIGPTDARKakiSHPNSIRAMCGLDSEKNCVHGSDSPESAEREISFFF--GDVSS 167
NDPk5 cd04418
Nucleoside diphosphate kinase homolog 5 (NDP kinase homolog 5, NDPk5, NM23-H5; Inhibitor of ...
 4-134 3.16e-15

Nucleoside diphosphate kinase homolog 5 (NDP kinase homolog 5, NDPk5, NM23-H5; Inhibitor of p53-induced apoptosis-beta, IPIA-beta): In human, mRNA for NDPk5 is almost exclusively found in testis, especially in the flagella of spermatids and spermatozoa, in association with axoneme microtubules, and may play a role in spermatogenesis by increasing the ability of late-stage spermatids to eliminate reactive oxygen species. It belongs to the nm23 Group II genes and appears to differ from the other human NDPks in that it lacks two important catalytic site residues, and thus does not appear to possess NDP kinase activity. NDPk5 confers protection from cell death by Bax and alters the cellular levels of several antioxidant enzymes, including glutathione peroxidase 5 (Gpx5).


Pssm-ID: 239880  Cd Length: 132  Bit Score: 67.46  E-value: 3.16e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624714079   4 ERTYIMVKPDGVQRGiiGEVLKRYEQRGLKLVAAKFCKPSEQVVAEHYVEHREKPFFSELCDFIGQGPVFCMIWEGPEAV 83
Cdd:cd04418     1 ERTLAIIKPDAVHKA--EEIEDIILESGFTIVQKRKLQLSPEQCSDFYAEHYGKMFFPHLVAYMSSGPIVAMVLARHNAI 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1624714079  84 KIGRKVVGVTSPL---ESDAGTIRGDFGVVTHLNLVHASSSIEDAERECHLWFK 134
Cdd:cd04418    79 SYWKELLGPTNSLkakETHPDSLRAIYGTDDLRNAVHGSDSFSSAEREIRFMFP 132
NDPk7B cd04412
Nucleoside diphosphate kinase 7 domain B (NDPk7B): The nm23-H7 class of nucleoside diphosphate ...
 5-133 3.35e-14

Nucleoside diphosphate kinase 7 domain B (NDPk7B): The nm23-H7 class of nucleoside diphosphate kinase (NDPk7) consists of an N-terminal DM10 domain and two functional catalytic NDPk modules, NDPk7A and NDPk7B. The function of the DM10 domain, which also occurs in multiple copies in other proteins, is unknown. NDPk7 is predominantly expressed in testes, although appreciable amount are also found in liver, heart, brain, ovary, small intestine and spleen. The nm23-H7 gene is located in or near the hereditary prostrate cancer susceptibility locus. Nm23-H7 may be involved in the development of colon and gastric carcinoma, the latter possibly in a type-specific manner.


Pssm-ID: 239875  Cd Length: 134  Bit Score: 64.96  E-value: 3.35e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624714079   5 RTYIMVKPDGVQRGIIGEVLKRYEQRGLKLVAAKFCKPSEQVVAEHYVEHR-EKPFFSELCDFIGQGPVFCMIWEGPEAV 83
Cdd:cd04412     2 CTVCIIKPHAVSHGLLGEILQQILDEGFEITALQMFNLTRANAEEFLEVYKgVVPELPAMVDELTSGPCIALEIAGENAV 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1624714079  84 KIGRKVVGVTSPLESDA---GTIRGDFGVVTHLNLVHASSSIEDAERECHLWF 133
Cdd:cd04412    82 KTFREFCGPFDPEIAKQlrpNTLRARYGKDKVQNAVHCTDLPEDGPLELKFFF 134
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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