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Conserved domains on  [gi|1624714123|ref|XP_028872416|]
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U3 small nucleolar RNA-associated protein 4 [Babesia sp. Xinjiang]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
16-369 8.03e-26

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 110.77  E-value: 8.03e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624714123  16 SSVNAVAFSPCGQYIAAARQPYAVEIYNVETRVHITSLReaEENAAVRTIIWIPkkegligktlSGYRIVTIGLHAVITD 95
Cdd:COG2319   121 GAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLT--GHSGAVTSVAFSP----------DGKLLASGSDDGTVRL 188

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624714123  96 WDLELLLPVRSCCSYGGAIFASALTENGTKVLIACDDGRVrsfRLWsegDKETREPELSFDKvyacHTKSILSICVLPDG 175
Cdd:COG2319   189 WDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTV---RLW---DLATGKLLRTLTG----HSGSVRSVAFSPDG 258

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624714123 176 SFF-CGTADSIIfKLHadadvpatkikvpgpkkqvgpatkkrkqstskfedDADTSAEI-TKGGNENqnntdesepQIWA 253
Cdd:COG2319   259 RLLaSGSADGTV-RLW-----------------------------------DLATGELLrTLTGHSG---------GVNS 293

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624714123 254 LVYIAKHQLLASGDSAGNVILWDVKTCTMHKMFTQHCADVLCLAVGADGDTLFSGGVDTQITVyaysernyikqnvpvgW 333
Cdd:COG2319   294 VAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRL----------------W 357

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|.
gi 1624714123 334 RANGVKYY-----HRGDVRCFAVHPNDDRIVSSGSDGILTI 369
Cdd:COG2319   358 DLATGELLrtltgHTGAVTSVAFSPDGRTLASGSADGTVRL 398
WD40 COG2319
WD40 repeat [General function prediction only];
250-616 4.38e-11

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 65.70  E-value: 4.38e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624714123 250 QIWALVYIAKHQLLASGDSAGNVILWDVKTCTMHKMFTQHCADVLCLAVGADGDTLFSGGVDTQITVYaysernyikqNV 329
Cdd:COG2319    80 AVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLW----------DL 149

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624714123 330 PVG---WRANGvkyyHRGDVRCFAVHPNDDRIVSSGSDGiltisrGLKHQNSKRCKTNLILLNIPSWVSKpVVMSRD-KT 405
Cdd:COG2319   150 ATGkllRTLTG----HSGAVTSVAFSPDGKLLASGSDDG------TVRLWDLATGKLLRTLTGHTGAVRS-VAFSPDgKL 218

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624714123 406 LALCRYRDHCDLWYIPKESQDDTempyklaaikLKKEGGQIIAAQLSADARFIAVANQ-KHLRIlkFNAENLEITAGKSY 484
Cdd:COG2319   219 LASGSADGTVRLWDLATGKLLRT----------LTGHSGSVRSVAFSPDGRLLASGSAdGTVRL--WDLATGELLRTLTG 286

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624714123 485 LEDvTVHAMHFVSNTKMLLSYLKKGTTTFllstLDLENGEIKHIehnIRDPVIKVDVARFSFNeklERTLITlYSLEGYV 564
Cdd:COG2319   287 HSG-GVNSVAFSPDGKLLASGSDDGTVRL----WDLATGKLLRT---LTGHTGAVRSVAFSPD---GKTLAS-GSDDGTV 354

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1624714123 565 YLLDLET-SEIHELPKFENgyRVVSTSASPDFKYLAVFSkgslfyfYDTELRI 616
Cdd:COG2319   355 RLWDLATgELLRTLTGHTG--AVTSVAFSPDGRTLASGS-------ADGTVRL 398
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
16-369 8.03e-26

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 110.77  E-value: 8.03e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624714123  16 SSVNAVAFSPCGQYIAAARQPYAVEIYNVETRVHITSLReaEENAAVRTIIWIPkkegligktlSGYRIVTIGLHAVITD 95
Cdd:COG2319   121 GAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLT--GHSGAVTSVAFSP----------DGKLLASGSDDGTVRL 188

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624714123  96 WDLELLLPVRSCCSYGGAIFASALTENGTKVLIACDDGRVrsfRLWsegDKETREPELSFDKvyacHTKSILSICVLPDG 175
Cdd:COG2319   189 WDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTV---RLW---DLATGKLLRTLTG----HSGSVRSVAFSPDG 258

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624714123 176 SFF-CGTADSIIfKLHadadvpatkikvpgpkkqvgpatkkrkqstskfedDADTSAEI-TKGGNENqnntdesepQIWA 253
Cdd:COG2319   259 RLLaSGSADGTV-RLW-----------------------------------DLATGELLrTLTGHSG---------GVNS 293

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624714123 254 LVYIAKHQLLASGDSAGNVILWDVKTCTMHKMFTQHCADVLCLAVGADGDTLFSGGVDTQITVyaysernyikqnvpvgW 333
Cdd:COG2319   294 VAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRL----------------W 357

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|.
gi 1624714123 334 RANGVKYY-----HRGDVRCFAVHPNDDRIVSSGSDGILTI 369
Cdd:COG2319   358 DLATGELLrtltgHTGAVTSVAFSPDGRTLASGSADGTVRL 398
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 7-318 7.69e-16

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 78.92  E-value: 7.69e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624714123   7 LVRIYDSNISSVNAVAFSPCGQYIAAARQPYAVEIYNVETRVHITSLREAEEnaAVRTIIWIPKKEGLigktLSGYRIVT 86
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTG--PVRDVAASADGTYL----ASGSSDKT 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624714123  87 IGLhavitdWDLELLLPVRSccsYGG---AIFASALTENGtKVLIAC-DDGRVRsfrLWsegDKETREPElsfdKVYACH 162
Cdd:cd00200    75 IRL------WDLETGECVRT---LTGhtsYVSSVAFSPDG-RILSSSsRDKTIK---VW---DVETGKCL----TTLRGH 134

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624714123 163 TKSILSICVLPDGSF-FCGTADSIIfKLhadADVPATK-IKV-PGPKKQVgpatkkrkqSTSKFEDDA------------ 227
Cdd:cd00200   135 TDWVNSVAFSPDGTFvASSSQDGTI-KL---WDLRTGKcVATlTGHTGEV---------NSVAFSPDGekllssssdgti 201

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624714123 228 ---DTSAEITKGGNENQNNtdesepQIWALVYIAKHQLLASGDSAGNVILWDVKTCTMHKMFTQHCADVLCLAVGADGDT 304
Cdd:cd00200   202 klwDLSTGKCLGTLRGHEN------GVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKR 275

                         330
                  ....*....|....
gi 1624714123 305 LFSGGVDTQITVYA 318
Cdd:cd00200   276 LASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
250-616 4.38e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 65.70  E-value: 4.38e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624714123 250 QIWALVYIAKHQLLASGDSAGNVILWDVKTCTMHKMFTQHCADVLCLAVGADGDTLFSGGVDTQITVYaysernyikqNV 329
Cdd:COG2319    80 AVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLW----------DL 149

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624714123 330 PVG---WRANGvkyyHRGDVRCFAVHPNDDRIVSSGSDGiltisrGLKHQNSKRCKTNLILLNIPSWVSKpVVMSRD-KT 405
Cdd:COG2319   150 ATGkllRTLTG----HSGAVTSVAFSPDGKLLASGSDDG------TVRLWDLATGKLLRTLTGHTGAVRS-VAFSPDgKL 218

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624714123 406 LALCRYRDHCDLWYIPKESQDDTempyklaaikLKKEGGQIIAAQLSADARFIAVANQ-KHLRIlkFNAENLEITAGKSY 484
Cdd:COG2319   219 LASGSADGTVRLWDLATGKLLRT----------LTGHSGSVRSVAFSPDGRLLASGSAdGTVRL--WDLATGELLRTLTG 286

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624714123 485 LEDvTVHAMHFVSNTKMLLSYLKKGTTTFllstLDLENGEIKHIehnIRDPVIKVDVARFSFNeklERTLITlYSLEGYV 564
Cdd:COG2319   287 HSG-GVNSVAFSPDGKLLASGSDDGTVRL----WDLATGKLLRT---LTGHTGAVRSVAFSPD---GKTLAS-GSDDGTV 354

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1624714123 565 YLLDLET-SEIHELPKFENgyRVVSTSASPDFKYLAVFSkgslfyfYDTELRI 616
Cdd:COG2319   355 RLWDLATgELLRTLTGHTG--AVTSVAFSPDGRTLASGS-------ADGTVRL 398
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 342-369 5.06e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 35.37  E-value: 5.06e-03
                           10        20
                   ....*....|....*....|....*...
gi 1624714123  342 HRGDVRCFAVHPNDDRIVSSGSDGILTI 369
Cdd:smart00320  11 HTGPVTSVAFSPDGKYLASGSDDGTIKL 38
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
16-369 8.03e-26

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 110.77  E-value: 8.03e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624714123  16 SSVNAVAFSPCGQYIAAARQPYAVEIYNVETRVHITSLReaEENAAVRTIIWIPkkegligktlSGYRIVTIGLHAVITD 95
Cdd:COG2319   121 GAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLT--GHSGAVTSVAFSP----------DGKLLASGSDDGTVRL 188

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624714123  96 WDLELLLPVRSCCSYGGAIFASALTENGTKVLIACDDGRVrsfRLWsegDKETREPELSFDKvyacHTKSILSICVLPDG 175
Cdd:COG2319   189 WDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTV---RLW---DLATGKLLRTLTG----HSGSVRSVAFSPDG 258

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624714123 176 SFF-CGTADSIIfKLHadadvpatkikvpgpkkqvgpatkkrkqstskfedDADTSAEI-TKGGNENqnntdesepQIWA 253
Cdd:COG2319   259 RLLaSGSADGTV-RLW-----------------------------------DLATGELLrTLTGHSG---------GVNS 293

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624714123 254 LVYIAKHQLLASGDSAGNVILWDVKTCTMHKMFTQHCADVLCLAVGADGDTLFSGGVDTQITVyaysernyikqnvpvgW 333
Cdd:COG2319   294 VAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRL----------------W 357

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|.
gi 1624714123 334 RANGVKYY-----HRGDVRCFAVHPNDDRIVSSGSDGILTI 369
Cdd:COG2319   358 DLATGELLrtltgHTGAVTSVAFSPDGRTLASGSADGTVRL 398
WD40 COG2319
WD40 repeat [General function prediction only];
6-369 4.28e-23

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 102.68  E-value: 4.28e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624714123   6 ALVRIYDSNISSVNAVAFSPCGQYIAAARQPYAVEIYNVETRVHITSLREAEEnaAVRTIIWIPkkegligktlSGYRIV 85
Cdd:COG2319    69 ALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTG--AVRSVAFSP----------DGKTLA 136

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624714123  86 TIGLHAVITDWDLELLLPVRSCCSYGGAIFASALTENGTKVLIACDDGRVRsfrLWsegDKETREPELSFDKvyacHTKS 165
Cdd:COG2319   137 SGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVR---LW---DLATGKLLRTLTG----HTGA 206

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624714123 166 ILSICVLPDGSFF-CGTADSIIfKLHadadvpatkikvpgpkkqvgpatkkrkqstskfedDADTSAEITKggnenqnnT 244
Cdd:COG2319   207 VRSVAFSPDGKLLaSGSADGTV-RLW-----------------------------------DLATGKLLRT--------L 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624714123 245 DESEPQIWALVYIAKHQLLASGDSAGNVILWDVKTCTMHKMFTQHCADVLCLAVGADGDTLFSGGVDTQITVYayserny 324
Cdd:COG2319   243 TGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLW------- 315

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*
gi 1624714123 325 ikqNVPVGWRANGVKyYHRGDVRCFAVHPNDDRIVSSGSDGILTI 369
Cdd:COG2319   316 ---DLATGKLLRTLT-GHTGAVRSVAFSPDGKTLASGSDDGTVRL 356
WD40 COG2319
WD40 repeat [General function prediction only];
7-317 1.28e-18

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 88.81  E-value: 1.28e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624714123   7 LVRIYDSNISSVNAVAFSPCGQYIAAARQPYAVEIYNVETRVHITSLReaEENAAVRTIIWIPKkegliGKTL---SGYR 83
Cdd:COG2319   154 LLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLT--GHTGAVRSVAFSPD-----GKLLasgSADG 226

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624714123  84 IVTIglhavitdWDLELLLPVRSCCSYGGAIFASALTENGTKVLIACDDGRVrsfRLWsegDKETREPELSFDKvyacHT 163
Cdd:COG2319   227 TVRL--------WDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTV---RLW---DLATGELLRTLTG----HS 288

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624714123 164 KSILSICVLPDGSFF-CGTADSiifklhadadvpatKIKVPgpkkqvgpatkkrkqstskfedDADTSAEI-TKGGNENq 241
Cdd:COG2319   289 GGVNSVAFSPDGKLLaSGSDDG--------------TVRLW----------------------DLATGKLLrTLTGHTG- 331

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1624714123 242 nntdesepQIWALVYIAKHQLLASGDSAGNVILWDVKTCTMHKMFTQHCADVLCLAVGADGDTLFSGGVDTQITVY 317
Cdd:COG2319   332 --------AVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLW 399
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 7-318 7.69e-16

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 78.92  E-value: 7.69e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624714123   7 LVRIYDSNISSVNAVAFSPCGQYIAAARQPYAVEIYNVETRVHITSLREAEEnaAVRTIIWIPKKEGLigktLSGYRIVT 86
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTG--PVRDVAASADGTYL----ASGSSDKT 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624714123  87 IGLhavitdWDLELLLPVRSccsYGG---AIFASALTENGtKVLIAC-DDGRVRsfrLWsegDKETREPElsfdKVYACH 162
Cdd:cd00200    75 IRL------WDLETGECVRT---LTGhtsYVSSVAFSPDG-RILSSSsRDKTIK---VW---DVETGKCL----TTLRGH 134

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624714123 163 TKSILSICVLPDGSF-FCGTADSIIfKLhadADVPATK-IKV-PGPKKQVgpatkkrkqSTSKFEDDA------------ 227
Cdd:cd00200   135 TDWVNSVAFSPDGTFvASSSQDGTI-KL---WDLRTGKcVATlTGHTGEV---------NSVAFSPDGekllssssdgti 201

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624714123 228 ---DTSAEITKGGNENQNNtdesepQIWALVYIAKHQLLASGDSAGNVILWDVKTCTMHKMFTQHCADVLCLAVGADGDT 304
Cdd:cd00200   202 klwDLSTGKCLGTLRGHEN------GVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKR 275

                         330
                  ....*....|....
gi 1624714123 305 LFSGGVDTQITVYA 318
Cdd:cd00200   276 LASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
79-461 3.77e-13

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 72.25  E-value: 3.77e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624714123  79 LSGYRIVTIGLHAVITDWDLELLLPVRSCCSYGGAIFASALTENGTKVLIACDDGRVRsfrLWsegDKETREPELSFDKv 158
Cdd:COG2319    46 PDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVR---LW---DLATGLLLRTLTG- 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624714123 159 yacHTKSILSICVLPDGSFF-CGTADSIIfKLHadadvpatkikvpgpkkqvgpatkkrkqstskfedDADTSAEI-TKG 236
Cdd:COG2319   119 ---HTGAVRSVAFSPDGKTLaSGSADGTV-RLW-----------------------------------DLATGKLLrTLT 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624714123 237 GNENQnntdesepqIWALVYIAKHQLLASGDSAGNVILWDVKTCTMHKMFTQHCADVLCLAVGADGDTLFSGGVDTQITV 316
Cdd:COG2319   160 GHSGA---------VTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRL 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624714123 317 yaysernyikqnvpvgWRANGVKY-----YHRGDVRCFAVHPNDDRIVSSGSDGILTisrgLKHQNSKRCKTnlILLNIP 391
Cdd:COG2319   231 ----------------WDLATGKLlrtltGHSGSVRSVAFSPDGRLLASGSADGTVR----LWDLATGELLR--TLTGHS 288

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1624714123 392 SWVSKpVVMSRD-KTLALCRYRDHCDLWyipkesqdDTEMPYKLAAikLKKEGGQIIAAQLSADARFIAVA 461
Cdd:COG2319   289 GGVNS-VAFSPDgKLLASGSDDGTVRLW--------DLATGKLLRT--LTGHTGAVRSVAFSPDGKTLASG 348
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 251-369 4.30e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 70.44  E-value: 4.30e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624714123 251 IWALVYIAKHQLLASGDSAGNVILWDVKTCTMHKMFTQHCADVLCLAVGADGDTLFSGGVDTQITVYaysernyikqNVP 330
Cdd:cd00200    54 VRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVW----------DVE 123

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1624714123 331 VGwRANGVKYYHRGDVRCFAVHPNDDRIVSSGSDGILTI 369
Cdd:cd00200   124 TG-KCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKL 161
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 96-367 6.45e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 70.06  E-value: 6.45e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624714123  96 WDLELLLPVRSCCSYGGAIFASALTENGTKVLIACDDGRVRsfrLWS-EGDKETREpelsfdkvYACHTKSILSICVLPD 174
Cdd:cd00200    36 WDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIR---LWDlETGECVRT--------LTGHTSYVSSVAFSPD 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624714123 175 GSFFCGTadsiifklhadadvpatkikvpgpkkqvgpatkkRKQSTSKFEDDADTSAEITKGGNENQnntdesepqIWAL 254
Cdd:cd00200   105 GRILSSS----------------------------------SRDKTIKVWDVETGKCLTTLRGHTDW---------VNSV 141

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624714123 255 VYIAKHQLLASGDSAGNVILWDVKTCTMHKMFTQHCADVLCLAVGADGDTLFSGGVDTQITVYAYSERNYIKQNVpvgwr 334
Cdd:cd00200   142 AFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLR----- 216

                         250       260       270
                  ....*....|....*....|....*....|...
gi 1624714123 335 angvkyYHRGDVRCFAVHPNDDRIVSSGSDGIL 367
Cdd:cd00200   217 ------GHENGVNSVAFSPDGYLLASGSEDGTI 243
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 251-369 2.46e-12

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 68.13  E-value: 2.46e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624714123 251 IWALVYIAKHQLLASGDSAGNVILWDVKTCTMHKMFTQHCADVLCLAVGADGDTLFSGGVDTQITVYAYSERNYIKQNVP 330
Cdd:cd00200    96 VSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTG 175

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1624714123 331 vgwrangvkyyHRGDVRCFAVHPNDDRIVSSGSDGILTI 369
Cdd:cd00200   176 -----------HTGEVNSVAFSPDGEKLLSSSSDGTIKL 203
WD40 COG2319
WD40 repeat [General function prediction only];
250-616 4.38e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 65.70  E-value: 4.38e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624714123 250 QIWALVYIAKHQLLASGDSAGNVILWDVKTCTMHKMFTQHCADVLCLAVGADGDTLFSGGVDTQITVYaysernyikqNV 329
Cdd:COG2319    80 AVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLW----------DL 149

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624714123 330 PVG---WRANGvkyyHRGDVRCFAVHPNDDRIVSSGSDGiltisrGLKHQNSKRCKTNLILLNIPSWVSKpVVMSRD-KT 405
Cdd:COG2319   150 ATGkllRTLTG----HSGAVTSVAFSPDGKLLASGSDDG------TVRLWDLATGKLLRTLTGHTGAVRS-VAFSPDgKL 218

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624714123 406 LALCRYRDHCDLWYIPKESQDDTempyklaaikLKKEGGQIIAAQLSADARFIAVANQ-KHLRIlkFNAENLEITAGKSY 484
Cdd:COG2319   219 LASGSADGTVRLWDLATGKLLRT----------LTGHSGSVRSVAFSPDGRLLASGSAdGTVRL--WDLATGELLRTLTG 286

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624714123 485 LEDvTVHAMHFVSNTKMLLSYLKKGTTTFllstLDLENGEIKHIehnIRDPVIKVDVARFSFNeklERTLITlYSLEGYV 564
Cdd:COG2319   287 HSG-GVNSVAFSPDGKLLASGSDDGTVRL----WDLATGKLLRT---LTGHTGAVRSVAFSPD---GKTLAS-GSDDGTV 354

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1624714123 565 YLLDLET-SEIHELPKFENgyRVVSTSASPDFKYLAVFSkgslfyfYDTELRI 616
Cdd:COG2319   355 RLWDLATgELLRTLTGHTG--AVTSVAFSPDGRTLASGS-------ADGTVRL 398
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 251-415 4.33e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 61.58  E-value: 4.33e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624714123 251 IWALVYIAKHQLLASGDSAGNVILWDVKTCTMHKMFTQHCADVLCLAVGADGDTLFSGGVDTQITVyaysernYIKQNVP 330
Cdd:cd00200    12 VTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRL-------WDLETGE 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624714123 331 VGWRANGvkyyHRGDVRCFAVHPNDDRIVSSGSDGilTIsrGLKHQNSKRCKTNliLLNIPSWVSKpVVMSRDKTLALCR 410
Cdd:cd00200    85 CVRTLTG----HTSYVSSVAFSPDGRILSSSSRDK--TI--KVWDVETGKCLTT--LRGHTDWVNS-VAFSPDGTFVASS 153


                  ....*
gi 1624714123 411 YRDHC 415
Cdd:cd00200   154 SQDGT 158
WD40 COG2319
WD40 repeat [General function prediction only];
7-142 9.69e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 61.47  E-value: 9.69e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624714123   7 LVRIYDSNISSVNAVAFSPCGQYIAAARQPYAVEIYNVETRVHITSLREaeENAAVRTIIWIPKkegliGKTL-SGYRIV 85
Cdd:COG2319   280 LLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTG--HTGAVRSVAFSPD-----GKTLaSGSDDG 352

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1624714123  86 TIGLhavitdWDLELLLPVRSCCSYGGAIFASALTENGTKVLIACDDGRVrsfRLWS 142
Cdd:COG2319   353 TVRL------WDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTV---RLWD 400
WD40 COG2319
WD40 repeat [General function prediction only];
250-627 1.59e-06

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 51.07  E-value: 1.59e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624714123 250 QIWALVYIAKHQLLASGDSAGNVILWDVKTCTMHKMFTQHCADVLCLAVGADGDTLFSGGVDTQITVYAYSernyikqnv 329
Cdd:COG2319    38 AVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLA--------- 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624714123 330 pvGWRANGVKYYHRGDVRCFAVHPNDDRIVSSGSDGilTISrgLKHQNSKRCktnLILLNIPSWVSKPVVMSRD-KTLAL 408
Cdd:COG2319   109 --TGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADG--TVR--LWDLATGKL---LRTLTGHSGAVTSVAFSPDgKLLAS 179

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624714123 409 CRYRDHCDLWYIPKESQDDTempyklaaikLKKEGGQIIAAQLSADARFIAVA-NQKHLRIlkFNAEN---LEITAGKSY 484
Cdd:COG2319   180 GSDDGTVRLWDLATGKLLRT----------LTGHTGAVRSVAFSPDGKLLASGsADGTVRL--WDLATgklLRTLTGHSG 247

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624714123 485 ledvTVHAMHFVSNTKMLLSYLKKGTTTFllstLDLENGEIKHIEHNIRDPVIKVdvaRFSFNeklERTLITLySLEGYV 564
Cdd:COG2319   248 ----SVRSVAFSPDGRLLASGSADGTVRL----WDLATGELLRTLTGHSGGVNSV---AFSPD---GKLLASG-SDDGTV 312

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1624714123 565 YLLDLETSE-IHELPkfENGYRVVSTSASPDFKYLAVfskGSlfyfYDTELRIIAAYDGETIHR 627
Cdd:COG2319   313 RLWDLATGKlLRTLT--GHTGAVRSVAFSPDGKTLAS---GS----DDGTVRLWDLATGELLRT 367
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 282-369 1.61e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 47.33  E-value: 1.61e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624714123 282 MHKMFTQHCADVLCLAVGADGDTLFSGGVDTQITVYAYSERNYIKQNVPvgwrangvkyyHRGDVRCFAVHPNDDRIVSS 361
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKG-----------HTGPVRDVAASADGTYLASG 69


                  ....*...
gi 1624714123 362 GSDGILTI 369
Cdd:cd00200    70 SSDKTIRL 77
WD40 COG2319
WD40 repeat [General function prediction only];
6-99 1.21e-03

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 42.21  E-value: 1.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624714123   6 ALVRIYDSNISSVNAVAFSPCGQYIAAARQPYAVEIYNVETRVHITSLREAEenAAVRTIIWIPKkegliGKTLsgyriV 85
Cdd:COG2319   321 KLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHT--GAVTSVAFSPD-----GRTL-----A 388

                          90
                  ....*....|....
gi 1624714123  86 TIGLHAVITDWDLE 99
Cdd:COG2319   389 SGSADGTVRLWDLA 402
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 342-369 5.06e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 35.37  E-value: 5.06e-03
                           10        20
                   ....*....|....*....|....*...
gi 1624714123  342 HRGDVRCFAVHPNDDRIVSSGSDGILTI 369
Cdd:smart00320  11 HTGPVTSVAFSPDGKYLASGSDDGTIKL 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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