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Conserved domains on  [gi|1685642738|ref|XP_029367549|]
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ataxin-2-like isoform X4 [Echeneis naucrates]

Protein Classification

PAT1 family protein( domain architecture ID 1001013)

PAT1 family protein similar to Saccharomyces cerevisiae DNA topoisomerase 2-associated protein PAT1, an activator of decapping that functions as a general and active mechanism of translational repression and required for P-body formation

Gene Ontology:  GO:0003723

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 176-663 6.60e-09

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 60.34  E-value: 6.60e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1685642738  176 PVHLLPPAPPPRY--QSGPSSLP-PRATTPTRPPSRPPSRPsrppshsshpsfpsssssfshhgPTSPASTLPKRMSSEG 252
Cdd:PHA03247  2551 PPPPLPPAAPPAApdRSVPPPRPaPRPSEPAVTSRARRPDA-----------------------PPQSARPRAPVDDRGD 2607

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1685642738  253 PPRMSPKSQRTPRAHRVPPCRTSGVPPGvdlisHNAPGEVPSTPPTRSNSSGGTWSSVVSGGHRPRSPRQNSLGASSPGS 332
Cdd:PHA03247  2608 PRGPAPPSPLPPDTHAPDPPPPSPSPAA-----NEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQR 2682

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1685642738  333 SSLPSAQTGTAPVETVA-----PPTSVSSPTAASPAPNMVASPSGDAKECRVQETRQTSPSANKENIKPLDSSPSITRPV 407
Cdd:PHA03247  2683 PRRRAARPTVGSLTSLAdppppPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPT 2762

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1685642738  408 CKGPPSMAPDHRKQIDNLKkfsvdfRLQSSSNPDPAFDQMMTKTPRDPADKPKDLPldkvstvgregteegVGVAAGTTS 487
Cdd:PHA03247  2763 TAGPPAPAPPAAPAAGPPR------RLTRPAVASLSESRESLPSPWDPADPPAAVL---------------APAAALPPA 2821

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1685642738  488 GAPAPSANTTNTSKPGSPaALSPSPSAPDQKRAGLDVTSQGV--QTTSTSTFSGPKHEEKEDKKEAVQDQVRKSTLNPNA 565
Cdd:PHA03247  2822 ASPAGPLPPPTSAQPTAP-PPPPGPPPPSLPLGGSVAPGGDVrrRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFAL 2900

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1685642738  566 NEFKPRFNTQPKPANTPTP-PRPQGQPSPSIVVQQPPTVYSQTVCFPQMYPLTPVSPGVQKSIIwKSPAMYQVQMPHMTV 644
Cdd:PHA03247  2901 PPDQPERPPQPQAPPPPQPqPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWL-GALVPGRVAVPRFRV 2979

                          490
                   ....*....|....*....
gi 1685642738  645 SQSKPYRPGKVPNMPQQRS 663
Cdd:PHA03247  2980 PQPAPSREAPASSTPPLTG 2998
PAT1 super family cl37801
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 571-821 3.69e-06

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


The actual alignment was detected with superfamily member pfam09770:

Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 50.80  E-value: 3.69e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1685642738 571 RFNTQpKPANTPTPPRPQGQPSPSIVVQQPPTvysqtvcfPQMYPLTPVSPGVQKsiiWKSPAmyqvQMPHMTVSQS--- 647
Cdd:pfam09770 101 RFNRQ-QPAARAAQSSAQPPASSLPQYQYASQ--------QSQQPSKPVRTGYEK---YKEPE----PIPDLQVDASlwg 164

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1685642738 648 -KPYRPGKVPNMPQQRSDQHHPPGT-PTMM-------------HPATAAGPPIVAPSPAYSAQYFPCSPQQFTSQPLVQQ 712
Cdd:pfam09770 165 vAPKKAAAPAPAPQPAAQPASLPAPsRKMMsleeveaamraqaKKPAQQPAPAPAQPPAAPPAQQAQQQQQFPPQIQQQQ 244

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1685642738 713 MthyqSQAQHVFSPVMQGSARMMAPPTHGQPSLVSSSTTQYPEQTHTMYGMSAHHFVSPGPMPQQYPHPSTTLHPHPQHP 792
Cdd:pfam09770 245 Q----PQQQPQQPQQHPGQGHPVTILQRPQSPQPDPAQPSIQPQAQQFHQQPPPVPVQPTQILQNPNRLSAARVGYPQNP 320

                         250       260
                  ....*....|....*....|....*....
gi 1685642738 793 QPSATPTGQAQQGGPPQHGGPPSHPAASP 821
Cdd:pfam09770 321 QPGVQPAPAHQAHRQQGSFGRQAPIITHP 349
 
Name Accession Description Interval E-value
PHA03247 PHA03247
large tegument protein UL36; Provisional
 176-663 6.60e-09

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 60.34  E-value: 6.60e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1685642738  176 PVHLLPPAPPPRY--QSGPSSLP-PRATTPTRPPSRPPSRPsrppshsshpsfpsssssfshhgPTSPASTLPKRMSSEG 252
Cdd:PHA03247  2551 PPPPLPPAAPPAApdRSVPPPRPaPRPSEPAVTSRARRPDA-----------------------PPQSARPRAPVDDRGD 2607

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1685642738  253 PPRMSPKSQRTPRAHRVPPCRTSGVPPGvdlisHNAPGEVPSTPPTRSNSSGGTWSSVVSGGHRPRSPRQNSLGASSPGS 332
Cdd:PHA03247  2608 PRGPAPPSPLPPDTHAPDPPPPSPSPAA-----NEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQR 2682

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1685642738  333 SSLPSAQTGTAPVETVA-----PPTSVSSPTAASPAPNMVASPSGDAKECRVQETRQTSPSANKENIKPLDSSPSITRPV 407
Cdd:PHA03247  2683 PRRRAARPTVGSLTSLAdppppPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPT 2762

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1685642738  408 CKGPPSMAPDHRKQIDNLKkfsvdfRLQSSSNPDPAFDQMMTKTPRDPADKPKDLPldkvstvgregteegVGVAAGTTS 487
Cdd:PHA03247  2763 TAGPPAPAPPAAPAAGPPR------RLTRPAVASLSESRESLPSPWDPADPPAAVL---------------APAAALPPA 2821

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1685642738  488 GAPAPSANTTNTSKPGSPaALSPSPSAPDQKRAGLDVTSQGV--QTTSTSTFSGPKHEEKEDKKEAVQDQVRKSTLNPNA 565
Cdd:PHA03247  2822 ASPAGPLPPPTSAQPTAP-PPPPGPPPPSLPLGGSVAPGGDVrrRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFAL 2900

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1685642738  566 NEFKPRFNTQPKPANTPTP-PRPQGQPSPSIVVQQPPTVYSQTVCFPQMYPLTPVSPGVQKSIIwKSPAMYQVQMPHMTV 644
Cdd:PHA03247  2901 PPDQPERPPQPQAPPPPQPqPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWL-GALVPGRVAVPRFRV 2979

                          490
                   ....*....|....*....
gi 1685642738  645 SQSKPYRPGKVPNMPQQRS 663
Cdd:PHA03247  2980 PQPAPSREAPASSTPPLTG 2998
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 571-821 3.69e-06

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 50.80  E-value: 3.69e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1685642738 571 RFNTQpKPANTPTPPRPQGQPSPSIVVQQPPTvysqtvcfPQMYPLTPVSPGVQKsiiWKSPAmyqvQMPHMTVSQS--- 647
Cdd:pfam09770 101 RFNRQ-QPAARAAQSSAQPPASSLPQYQYASQ--------QSQQPSKPVRTGYEK---YKEPE----PIPDLQVDASlwg 164

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1685642738 648 -KPYRPGKVPNMPQQRSDQHHPPGT-PTMM-------------HPATAAGPPIVAPSPAYSAQYFPCSPQQFTSQPLVQQ 712
Cdd:pfam09770 165 vAPKKAAAPAPAPQPAAQPASLPAPsRKMMsleeveaamraqaKKPAQQPAPAPAQPPAAPPAQQAQQQQQFPPQIQQQQ 244

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1685642738 713 MthyqSQAQHVFSPVMQGSARMMAPPTHGQPSLVSSSTTQYPEQTHTMYGMSAHHFVSPGPMPQQYPHPSTTLHPHPQHP 792
Cdd:pfam09770 245 Q----PQQQPQQPQQHPGQGHPVTILQRPQSPQPDPAQPSIQPQAQQFHQQPPPVPVQPTQILQNPNRLSAARVGYPQNP 320

                         250       260
                  ....*....|....*....|....*....
gi 1685642738 793 QPSATPTGQAQQGGPPQHGGPPSHPAASP 821
Cdd:pfam09770 321 QPGVQPAPAHQAHRQQGSFGRQAPIITHP 349
PHA03247 PHA03247
large tegument protein UL36; Provisional
 489-921 1.83e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 45.70  E-value: 1.83e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1685642738  489 APAPSANTTNTSKPGSPAALSPSPSAPDQKRAGLDVTSQGVQTTSTSTFSGPKHEEKEDKKEAVQDqvrkSTLNPNANEF 568
Cdd:PHA03247  2556 PPAAPPAAPDRSVPPPRPAPRPSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDT----HAPDPPPPSP 2631

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1685642738  569 KPRFNTQPKPANTPTPPRPQGQPSPSivvqqPPTVYSQTVCFPQMYPLTPVSPGVQksiiWKSPAMYQVQMPHMTVSQSK 648
Cdd:PHA03247  2632 SPAANEPDPHPPPTVPPPERPRDDPA-----PGRVSRPRRARRLGRAAQASSPPQR----PRRRAARPTVGSLTSLADPP 2702

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1685642738  649 PYRPGKVPNMPQQRSDQHHPPGtPTMMHPATAAGPPIVAPSPAYSAQYFPCSPQQFTSQPLVQQMTHYQSQAQHVFSPVM 728
Cdd:PHA03247  2703 PPPPTPEPAPHALVSATPLPPG-PAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPR 2781

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1685642738  729 QGSARMMAPPTHGQPSLVSSSTTQYPEQTHTMYGMSAHHFVSPGPMPQQYPHPSTTLHPHPQHPQPSATPTGQAQQGGPP 808
Cdd:PHA03247  2782 RLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGD 2861

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1685642738  809 QHGGPPSHPAASPVQHPQHPQAAAAAAAAQALHLANQPPQQQMYSALAPTPPSMTPGPNPQSPQASFPSAQQtvyihPQQ 888
Cdd:PHA03247  2862 VRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPP-----PPP 2936

                          410       420       430
                   ....*....|....*....|....*....|...
gi 1685642738  889 VQHGYNPNHMAHVQQAHMQSGIVPSHHPGPTHP 921
Cdd:PHA03247  2937 PRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVP 2969
PAM2 pfam07145
Ataxin-2 C-terminal region; The PABP-interacting motif PAM2 has been identified in various ...
 557-573 9.52e-03

Ataxin-2 C-terminal region; The PABP-interacting motif PAM2 has been identified in various eukaryotic proteins as an important binding site for pfam00658. It has been found in a wide range of eukaryotic proteins. Strikingly, this motif appears to occur solely outside of globular domains.


Pssm-ID: 429316  Cd Length: 17  Bit Score: 34.51  E-value: 9.52e-03
                          10
                  ....*....|....*..
gi 1685642738 557 RKSTLNPNANEFKPRFN 573
Cdd:pfam07145   1 SKSKLNPNAKEFVPSFK 17
 
Name Accession Description Interval E-value
PHA03247 PHA03247
large tegument protein UL36; Provisional
 176-663 6.60e-09

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 60.34  E-value: 6.60e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1685642738  176 PVHLLPPAPPPRY--QSGPSSLP-PRATTPTRPPSRPPSRPsrppshsshpsfpsssssfshhgPTSPASTLPKRMSSEG 252
Cdd:PHA03247  2551 PPPPLPPAAPPAApdRSVPPPRPaPRPSEPAVTSRARRPDA-----------------------PPQSARPRAPVDDRGD 2607

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1685642738  253 PPRMSPKSQRTPRAHRVPPCRTSGVPPGvdlisHNAPGEVPSTPPTRSNSSGGTWSSVVSGGHRPRSPRQNSLGASSPGS 332
Cdd:PHA03247  2608 PRGPAPPSPLPPDTHAPDPPPPSPSPAA-----NEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQR 2682

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1685642738  333 SSLPSAQTGTAPVETVA-----PPTSVSSPTAASPAPNMVASPSGDAKECRVQETRQTSPSANKENIKPLDSSPSITRPV 407
Cdd:PHA03247  2683 PRRRAARPTVGSLTSLAdppppPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPT 2762

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1685642738  408 CKGPPSMAPDHRKQIDNLKkfsvdfRLQSSSNPDPAFDQMMTKTPRDPADKPKDLPldkvstvgregteegVGVAAGTTS 487
Cdd:PHA03247  2763 TAGPPAPAPPAAPAAGPPR------RLTRPAVASLSESRESLPSPWDPADPPAAVL---------------APAAALPPA 2821

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1685642738  488 GAPAPSANTTNTSKPGSPaALSPSPSAPDQKRAGLDVTSQGV--QTTSTSTFSGPKHEEKEDKKEAVQDQVRKSTLNPNA 565
Cdd:PHA03247  2822 ASPAGPLPPPTSAQPTAP-PPPPGPPPPSLPLGGSVAPGGDVrrRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFAL 2900

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1685642738  566 NEFKPRFNTQPKPANTPTP-PRPQGQPSPSIVVQQPPTVYSQTVCFPQMYPLTPVSPGVQKSIIwKSPAMYQVQMPHMTV 644
Cdd:PHA03247  2901 PPDQPERPPQPQAPPPPQPqPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWL-GALVPGRVAVPRFRV 2979

                          490
                   ....*....|....*....
gi 1685642738  645 SQSKPYRPGKVPNMPQQRS 663
Cdd:PHA03247  2980 PQPAPSREAPASSTPPLTG 2998
PHA03247 PHA03247
large tegument protein UL36; Provisional
 145-696 8.60e-08

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 56.49  E-value: 8.60e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1685642738  145 PQLLDQDLTTTVPAP------GLTRGSLTEVHPIGPHPVHLLPPAPPPRYQSGPSSLPPRATTPtrpPSRPPSRPSRPPS 218
Cdd:PHA03247  2561 PAAPDRSVPPPRPAPrpsepaVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAP---DPPPPSPSPAANE 2637

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1685642738  219 HSSHPSFPSSSSSFSHHGPTSPASTLPKRMSSEGPPRMSPKSQRTPRAHRVPPcrtsGVPPGVDLISHNAPGEVPSTPPT 298
Cdd:PHA03247  2638 PDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARP----TVGSLTSLADPPPPPPTPEPAPH 2713

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1685642738  299 RSNSSGGTWSSVVSGGHR-------PRSPRQNSLGASSPGSSSLPSAQTGTAPVETVAPPTSVSSPTAASPAPNMV-ASP 370
Cdd:PHA03247  2714 ALVSATPLPPGPAAARQAspalpaaPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVAsLSE 2793

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1685642738  371 SGDAKECRVQETRQTSPSANKENIKPLDSSPSITRPVCKGPPSMAPdhrkqidNLKKFSVDFRLQSSSNPDPAFDQMMTK 450
Cdd:PHA03247  2794 SRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAP-------PPPPGPPPPSLPLGGSVAPGGDVRRRP 2866

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1685642738  451 TPRDPADKPKDLPLDKVSTVGRegteegvgvaagttsgaPAPSANTTNTSKPGSPAALSPSPSAPDQKRAGLDVTSQGVQ 530
Cdd:PHA03247  2867 PSRSPAAKPAAPARPPVRRLAR-----------------PAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQP 2929

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1685642738  531 TTSTSTFSGPKHEEKEDKKEAVQDQVRKSTLNPNANEFKPRFNTQPKP-ANTPTPPRPQGQPSPSIVVQQPPTVYSQTVC 609
Cdd:PHA03247  2930 QPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFrVPQPAPSREAPASSTPPLTGHSLSRVSSWAS 3009

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1685642738  610 FPQMYPLTPVSPGVQKSIIWKSPAMYQVQMPHMTVSQSKPYRPGKV-PNMPQQRSDQHHPPGTPT-----MMHPATAAGP 683
Cdd:PHA03247  3010 SLALHEETDPPPVSLKQTLWPPDDTEDSDADSLFDSDSERSDLEALdPLPPEPHDPFAHEPDPATpeagaRESPSSQFGP 3089

                          570
                   ....*....|...
gi 1685642738  684 PIVAPSPAYSAQY 696
Cdd:PHA03247  3090 PPLSANAALSRRY 3102
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 571-821 3.69e-06

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 50.80  E-value: 3.69e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1685642738 571 RFNTQpKPANTPTPPRPQGQPSPSIVVQQPPTvysqtvcfPQMYPLTPVSPGVQKsiiWKSPAmyqvQMPHMTVSQS--- 647
Cdd:pfam09770 101 RFNRQ-QPAARAAQSSAQPPASSLPQYQYASQ--------QSQQPSKPVRTGYEK---YKEPE----PIPDLQVDASlwg 164

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1685642738 648 -KPYRPGKVPNMPQQRSDQHHPPGT-PTMM-------------HPATAAGPPIVAPSPAYSAQYFPCSPQQFTSQPLVQQ 712
Cdd:pfam09770 165 vAPKKAAAPAPAPQPAAQPASLPAPsRKMMsleeveaamraqaKKPAQQPAPAPAQPPAAPPAQQAQQQQQFPPQIQQQQ 244

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1685642738 713 MthyqSQAQHVFSPVMQGSARMMAPPTHGQPSLVSSSTTQYPEQTHTMYGMSAHHFVSPGPMPQQYPHPSTTLHPHPQHP 792
Cdd:pfam09770 245 Q----PQQQPQQPQQHPGQGHPVTILQRPQSPQPDPAQPSIQPQAQQFHQQPPPVPVQPTQILQNPNRLSAARVGYPQNP 320

                         250       260
                  ....*....|....*....|....*....
gi 1685642738 793 QPSATPTGQAQQGGPPQHGGPPSHPAASP 821
Cdd:pfam09770 321 QPGVQPAPAHQAHRQQGSFGRQAPIITHP 349
PHA03247 PHA03247
large tegument protein UL36; Provisional
 186-721 6.88e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 47.24  E-value: 6.88e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1685642738  186 PRYQSGPSSLPPRATTPTRPPSRPPSRPSRPPSHSSHPSFPSSSSSFshhgptsPASTLPKRM-------------SSEG 252
Cdd:PHA03247  2478 PVYRRPAEARFPFAAGAAPDPGGGGPPDPDAPPAPSRLAPAILPDEP-------VGEPVHPRMltwirgleelasdDAGD 2550

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1685642738  253 PPRMSPKSQRTPRAHR-VPPCRTSGVPPGVDLISHNAPGEVPSTPptrsnssggtwssvvsggHRPRSPRQNslgasspG 331
Cdd:PHA03247  2551 PPPPLPPAAPPAAPDRsVPPPRPAPRPSEPAVTSRARRPDAPPQS------------------ARPRAPVDD-------R 2605

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1685642738  332 SSSLPSAQTGTAPVETVAPPTSVSSPtaaSPAPNMVASPSGDAKECRVQETRQTSPSankeNIKPLDSSPSITRPVCKGP 411
Cdd:PHA03247  2606 GDPRGPAPPSPLPPDTHAPDPPPPSP---SPAANEPDPHPPPTVPPPERPRDDPAPG----RVSRPRRARRLGRAAQASS 2678

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1685642738  412 PSMAPDHRkqidnlkkfsvdfrlqssSNPDPAFDQMMTKTPRDPADKPKDLPLDKVSTVGREGTEEGVGVAAGTTSGAPA 491
Cdd:PHA03247  2679 PPQRPRRR------------------AARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPA 2740

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1685642738  492 PSANTTNTSKPGSPA--------ALSPSPSAPDQKRAGLD--VTSQGVQTTSTSTFSGPKHEEKEDKKEAVqdQVRKSTL 561
Cdd:PHA03247  2741 PPAVPAGPATPGGPArparppttAGPPAPAPPAAPAAGPPrrLTRPAVASLSESRESLPSPWDPADPPAAV--LAPAAAL 2818

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1685642738  562 NPNAnefKPRFNTQPKPANTPTPPRPQGQPSPsivvqqpptvysqtvcfPQMYPLTPVSPGvqKSIIWKSPAMYQVQMPh 641
Cdd:PHA03247  2819 PPAA---SPAGPLPPPTSAQPTAPPPPPGPPP-----------------PSLPLGGSVAPG--GDVRRRPPSRSPAAKP- 2875

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1685642738  642 mTVSQSKPYRPGKVPNMPQQRSDQHHPPGTPTMMHPATAAGPPIVAPSPAYSAQYFPCSPQQFTSQPLVQQMTHYQSQAQ 721
Cdd:PHA03247  2876 -AAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGE 2954
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 676-921 8.82e-05

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 46.57  E-value: 8.82e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1685642738 676 HPATAAGPPIVAPSPAYSAQYFPCSPQ-QFTSQPLvqqMTHYQSQAQHVFSPVMQ--------GSARMMAPPTHGQPSLV 746
Cdd:pfam09770 106 QPAARAAQSSAQPPASSLPQYQYASQQsQQPSKPV---RTGYEKYKEPEPIPDLQvdaslwgvAPKKAAAPAPAPQPAAQ 182

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1685642738 747 SSSTTQYPEQTHTM----YGMSAHhfvSPGPMPQQYPHPSTTLHPHPQHPQPsatptgqaqqggppqhggppsHPAASPV 822
Cdd:pfam09770 183 PASLPAPSRKMMSLeeveAAMRAQ---AKKPAQQPAPAPAQPPAAPPAQQAQ---------------------QQQQFPP 238

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1685642738 823 QHPQHPQAAAAAAAAQALHLANQPPQQQMYSALAPTPPSMtpgPNPQSPQASFPSAQQTVYIHPQQVQHgyNPNhMAHVQ 902
Cdd:pfam09770 239 QIQQQQQPQQQPQQPQQHPGQGHPVTILQRPQSPQPDPAQ---PSIQPQAQQFHQQPPPVPVQPTQILQ--NPN-RLSAA 312

                         250
                  ....*....|....*....
gi 1685642738 903 QAHMQSGIVPSHHPGPTHP 921
Cdd:pfam09770 313 RVGYPQNPQPGVQPAPAHQ 331
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 700-891 1.77e-04

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 45.41  E-value: 1.77e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1685642738 700 SPQQFTSQPLVQQMTHYQSQAQHVFSPVM-----QGSARMMAPPTHGQPSLVSSSTTQYPEQTHTMYGMSAHHFVSPGPM 774
Cdd:pfam09770 166 APKKAAAPAPAPQPAAQPASLPAPSRKMMsleevEAAMRAQAKKPAQQPAPAPAQPPAAPPAQQAQQQQQFPPQIQQQQQ 245

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1685642738 775 PQQYPH--PSTTLHPHP----QHPQPSATPTGQAQQGGPPQHGGPPSHPAaspvqhpqhpqaaaAAAAAQALHLANQPPQ 848
Cdd:pfam09770 246 PQQQPQqpQQHPGQGHPvtilQRPQSPQPDPAQPSIQPQAQQFHQQPPPV--------------PVQPTQILQNPNRLSA 311

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1685642738 849 QQMYSALAPTPPSMTPGPNPQSPQASFPSAQQTVYIHPQQVQH 891
Cdd:pfam09770 312 ARVGYPQNPQPGVQPAPAHQAHRQQGSFGRQAPIITHPQQLAQ 354
PHA03247 PHA03247
large tegument protein UL36; Provisional
 489-921 1.83e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 45.70  E-value: 1.83e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1685642738  489 APAPSANTTNTSKPGSPAALSPSPSAPDQKRAGLDVTSQGVQTTSTSTFSGPKHEEKEDKKEAVQDqvrkSTLNPNANEF 568
Cdd:PHA03247  2556 PPAAPPAAPDRSVPPPRPAPRPSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDT----HAPDPPPPSP 2631

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1685642738  569 KPRFNTQPKPANTPTPPRPQGQPSPSivvqqPPTVYSQTVCFPQMYPLTPVSPGVQksiiWKSPAMYQVQMPHMTVSQSK 648
Cdd:PHA03247  2632 SPAANEPDPHPPPTVPPPERPRDDPA-----PGRVSRPRRARRLGRAAQASSPPQR----PRRRAARPTVGSLTSLADPP 2702

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1685642738  649 PYRPGKVPNMPQQRSDQHHPPGtPTMMHPATAAGPPIVAPSPAYSAQYFPCSPQQFTSQPLVQQMTHYQSQAQHVFSPVM 728
Cdd:PHA03247  2703 PPPPTPEPAPHALVSATPLPPG-PAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPR 2781

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1685642738  729 QGSARMMAPPTHGQPSLVSSSTTQYPEQTHTMYGMSAHHFVSPGPMPQQYPHPSTTLHPHPQHPQPSATPTGQAQQGGPP 808
Cdd:PHA03247  2782 RLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGD 2861

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1685642738  809 QHGGPPSHPAASPVQHPQHPQAAAAAAAAQALHLANQPPQQQMYSALAPTPPSMTPGPNPQSPQASFPSAQQtvyihPQQ 888
Cdd:PHA03247  2862 VRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPP-----PPP 2936

                          410       420       430
                   ....*....|....*....|....*....|...
gi 1685642738  889 VQHGYNPNHMAHVQQAHMQSGIVPSHHPGPTHP 921
Cdd:PHA03247  2937 PRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVP 2969
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 509-882 1.10e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 42.83  E-value: 1.10e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1685642738 509 SPSPSAPDQKRAGLDVTSQGVQTTSTSTFSGPKHEEKEDKKEAVQDQVRKSTLNPNANefKPRFNTQPKPANTPTPPRPQ 588
Cdd:pfam03154 145 SPSIPSPQDNESDSDSSAQQQILQTQPPVLQAQSGAASPPSPPPPGTTQAATAGPTPS--APSVPPQGSPATSQPPNQTQ 222

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1685642738 589 GQPSPSIVVQQPPTVYSQTVCFPQ--MYPLTPVSPGVQKSIIWKSPAMYQVQMPHM--TVSQSKPYRPGKVPNMPQqrsd 664
Cdd:pfam03154 223 STAAPHTLIQQTPTLHPQRLPSPHppLQPMTQPPPPSQVSPQPLPQPSLHGQMPPMphSLQTGPSHMQHPVPPQPF---- 298

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1685642738 665 qhhpPGTPTMMHPATAAGPPIVAPSPAYSAQYFPCSPQQFTSQ--PLVQQMTHYQSQAQHVFSPVMQGSARMMAPPTHGQ 742
Cdd:pfam03154 299 ----PLTPQSSQSQVPPGPSPAAPGQSQQRIHTPPSQSQLQSQqpPREQPLPPAPLSMPHIKPPPTTPIPQLPNPQSHKH 374

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1685642738 743 PSLVSS-------STTQYPEQTHTMYGMSAHHFVSPGPMPQQYPHPSTTLHPHPQHPqPSATPTGQAQQGGPPQHGGPPS 815
Cdd:pfam03154 375 PPHLSGpspfqmnSNLPPPPALKPLSSLSTHHPPSAHPPPLQLMPQSQQLPPPPAQP-PVLTQSQSLPPPAASHPPTSGL 453

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1685642738 816 HPAASpvqhpqhpqaaaaaaaaqalhlanQPPQQQmYSALAPTPPSMTPgpnPQSPQASFPSAQQTV 882
Cdd:pfam03154 454 HQVPS------------------------QSPFPQ-HPFVPGGPPPITP---PSGPPTSTSSAMPGI 492
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 702-919 5.77e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 40.52  E-value: 5.77e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1685642738 702 QQFTSQPLVQQMTHYQSQAQHVFSPVMQGSARMMAPPTHGQPSLVSSSTTQYPEQTHTMYGMSAHHFVSPGPMPQQYPHP 781
Cdd:pfam03154 166 ILQTQPPVLQAQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPHTLIQQTPTLHPQRLPSP 245

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1685642738 782 STTLHPHPQHPQPSATPTGQAQQGGPPQHGGPPSHPAASPVQHPQHPQAAAAAAAAQALHLANQPPQQQMYSALAPTPPS 861
Cdd:pfam03154 246 HPPLQPMTQPPPPSQVSPQPLPQPSLHGQMPPMPHSLQTGPSHMQHPVPPQPFPLTPQSSQSQVPPGPSPAAPGQSQQRI 325

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1685642738 862 MTPGPNPQSPQASfPSAQQTVYIHPQQVQHGYNPNHMAHVQQAHMQSGIVPSHHPGPT 919
Cdd:pfam03154 326 HTPPSQSQLQSQQ-PPREQPLPPAPLSMPHIKPPPTTPIPQLPNPQSHKHPPHLSGPS 382
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 576-755 8.51e-03

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 40.07  E-value: 8.51e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1685642738  576 PKPANTPTPPRPQGQPSPsivvqQPPTVYSQTVcfpqmypltpvsPGVQ--KSIIWKSPAMYQvQMPHMTVSQSKPYRPG 653
Cdd:PRK10263   336 PVEPVTQTPPVASVDVPP-----AQPTVAWQPV------------PGPQtgEPVIAPAPEGYP-QQSQYAQPAVQYNEPL 397

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1685642738  654 KVPNMPQQRSDQHHPPGTPTMMHPATAAGPPIVAPSPAYSAQYfPCSPQQFTSQPlvqQMTHYQSQAqhVFSPVMQGSAR 733
Cdd:PRK10263   398 QQPVQPQQPYYAPAAEQPAQQPYYAPAPEQPAQQPYYAPAPEQ-PVAGNAWQAEE---QQSTFAPQS--TYQTEQTYQQP 471

                          170       180
                   ....*....|....*....|..
gi 1685642738  734 MMAPPTHGQPSLVSSSTTQYPE 755
Cdd:PRK10263   472 AAQEPLYQQPQPVEQQPVVEPE 493
PAM2 pfam07145
Ataxin-2 C-terminal region; The PABP-interacting motif PAM2 has been identified in various ...
 557-573 9.52e-03

Ataxin-2 C-terminal region; The PABP-interacting motif PAM2 has been identified in various eukaryotic proteins as an important binding site for pfam00658. It has been found in a wide range of eukaryotic proteins. Strikingly, this motif appears to occur solely outside of globular domains.


Pssm-ID: 429316  Cd Length: 17  Bit Score: 34.51  E-value: 9.52e-03
                          10
                  ....*....|....*..
gi 1685642738 557 RKSTLNPNANEFKPRFN 573
Cdd:pfam07145   1 SKSKLNPNAKEFVPSFK 17
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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