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Conserved domains on  [gi|2015502074|ref|XP_029826701|]
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venom metalloproteinase antarease-like TtrivMP_A [Ixodes scapularis]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ZnMc_salivary_gland_MPs cd04272
Zinc-dependent metalloprotease, salivary_gland_MPs. Metalloproteases secreted by the salivary ...
 176-400 1.96e-120

Zinc-dependent metalloprotease, salivary_gland_MPs. Metalloproteases secreted by the salivary glands of arthropods.


:

Pssm-ID: 239800  Cd Length: 220  Bit Score: 351.65  E-value: 1.96e-120
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2015502074 176 IHPEVHLVVDSTFASAFkFDVYKVTRYFAVLTNAANLRYASFVFPKVQLRITGITMNKKPADEPYIHnvkgYEKYRNILF 255
Cdd:cd04272     1 VYPELFVVVDYDHQSEF-FSNEQLIRYLAVMVNAANLRYRDLKSPRIRLLLVGITISKDPDFEPYIH----PINYGYIDA 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2015502074 256 KETLEDFNKQMKSKPFYYTSDIVFLVTGKNMSEWVDGKLQHWVGGYAYLGTACSEWRVGMSEDPPTSYYGAYVFAHELAH 335
Cdd:cd04272    76 AETLENFNEYVKKKRDYFNPDVVFLVTGLDMSTYSGGSLQTGTGGYAYVGGACTENRVAMGEDTPGSYYGVYTMTHELAH 155

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2015502074 336 NLGCQHDGDGPSDWVKGHIGSADCPWDDGYLMSYKMQDERQYKFSYCCQREVRNLYNRPEFKCLR 400
Cdd:cd04272   156 LLGAPHDGSPPPSWVKGHPGSLDCPWDDGYIMSYVVNGERQYRFSQCSQRQIRNVFRRLGASCLH 220
Salp15 super family cl13541
Salivary protein of 15kDa inhibits CD4+ T cell activation; This is a family of 15kDa salivary ...
 438-483 2.09e-04

Salivary protein of 15kDa inhibits CD4+ T cell activation; This is a family of 15kDa salivary proteins from Acari Arachnids that is induced on feeding and assists the parasite to remain attached to its arthropod host. By repressing calcium fluxes triggered by TCR engagement, Salp15 inhibits CD4+ T cell activation. Salp15 shows weak similarity to Inhibin A, a member of the TGF-beta superfamily that inhibits the production of cytokines and the proliferation of T cells.


The actual alignment was detected with superfamily member pfam12115:

Pssm-ID: 314916  Cd Length: 112  Bit Score: 40.83  E-value: 2.09e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2015502074 438 DKTYGVRDCKVKCTGNTN------YWRLTvvDGTPCGK-KKACILGKCVNDIK 483
Cdd:pfam12115  60 DKLVDFKNCTFTCGKHNNggtnitLRQLP--DGTPCGPqGKTCKNGKCVGHVP 110
 
Name Accession Description Interval E-value
ZnMc_salivary_gland_MPs cd04272
Zinc-dependent metalloprotease, salivary_gland_MPs. Metalloproteases secreted by the salivary ...
 176-400 1.96e-120

Zinc-dependent metalloprotease, salivary_gland_MPs. Metalloproteases secreted by the salivary glands of arthropods.


Pssm-ID: 239800  Cd Length: 220  Bit Score: 351.65  E-value: 1.96e-120
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2015502074 176 IHPEVHLVVDSTFASAFkFDVYKVTRYFAVLTNAANLRYASFVFPKVQLRITGITMNKKPADEPYIHnvkgYEKYRNILF 255
Cdd:cd04272     1 VYPELFVVVDYDHQSEF-FSNEQLIRYLAVMVNAANLRYRDLKSPRIRLLLVGITISKDPDFEPYIH----PINYGYIDA 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2015502074 256 KETLEDFNKQMKSKPFYYTSDIVFLVTGKNMSEWVDGKLQHWVGGYAYLGTACSEWRVGMSEDPPTSYYGAYVFAHELAH 335
Cdd:cd04272    76 AETLENFNEYVKKKRDYFNPDVVFLVTGLDMSTYSGGSLQTGTGGYAYVGGACTENRVAMGEDTPGSYYGVYTMTHELAH 155

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2015502074 336 NLGCQHDGDGPSDWVKGHIGSADCPWDDGYLMSYKMQDERQYKFSYCCQREVRNLYNRPEFKCLR 400
Cdd:cd04272   156 LLGAPHDGSPPPSWVKGHPGSLDCPWDDGYIMSYVVNGERQYRFSQCSQRQIRNVFRRLGASCLH 220
Reprolysin_5 pfam13688
Metallo-peptidase family M12;
180-369 3.85e-15

Metallo-peptidase family M12;


Pssm-ID: 372673  Cd Length: 191  Bit Score: 73.61  E-value: 3.85e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2015502074 180 VHLVVDSTFASAFKFDVYKvTRYFAVLTNAANLRYASFvfpKVQLRITGITMNKKPADEPYIHNVKGYekyrnilFKETL 259
Cdd:pfam13688   7 LLVAADCSYVAAFGGDAAQ-ANIINMVNTASNVYERDF---NISLGLVNLTISDSTCPYTPPACSTGD-------SSDRL 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2015502074 260 EDFnkQMKSKP-FYYTSDIVFLVTGKNMSEwvdgklqhwvGGYAYLGTACSE-------WRVGMSEDPPTSYYGAYVFAH 331
Cdd:pfam13688  76 SEF--QDFSAWrGTQNDDLAYLFLMTNCSG----------GGLAWLGQLCNSgsagsvsTRVSGNNVVVSTATEWQVFAH 143

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 2015502074 332 ELAHNLGCQHDGDGPSDWVKGHIGSADCPWDDGYLMSY 369
Cdd:pfam13688 144 EIGHNFGAVHDCDSSTSSQCCPPSNSTCPAGGRYIMNP 181
Salp15 pfam12115
Salivary protein of 15kDa inhibits CD4+ T cell activation; This is a family of 15kDa salivary ...
 438-483 2.09e-04

Salivary protein of 15kDa inhibits CD4+ T cell activation; This is a family of 15kDa salivary proteins from Acari Arachnids that is induced on feeding and assists the parasite to remain attached to its arthropod host. By repressing calcium fluxes triggered by TCR engagement, Salp15 inhibits CD4+ T cell activation. Salp15 shows weak similarity to Inhibin A, a member of the TGF-beta superfamily that inhibits the production of cytokines and the proliferation of T cells.


Pssm-ID: 314916  Cd Length: 112  Bit Score: 40.83  E-value: 2.09e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2015502074 438 DKTYGVRDCKVKCTGNTN------YWRLTvvDGTPCGK-KKACILGKCVNDIK 483
Cdd:pfam12115  60 DKLVDFKNCTFTCGKHNNggtnitLRQLP--DGTPCGPqGKTCKNGKCVGHVP 110
 
Name Accession Description Interval E-value
ZnMc_salivary_gland_MPs cd04272
Zinc-dependent metalloprotease, salivary_gland_MPs. Metalloproteases secreted by the salivary ...
 176-400 1.96e-120

Zinc-dependent metalloprotease, salivary_gland_MPs. Metalloproteases secreted by the salivary glands of arthropods.


Pssm-ID: 239800  Cd Length: 220  Bit Score: 351.65  E-value: 1.96e-120
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2015502074 176 IHPEVHLVVDSTFASAFkFDVYKVTRYFAVLTNAANLRYASFVFPKVQLRITGITMNKKPADEPYIHnvkgYEKYRNILF 255
Cdd:cd04272     1 VYPELFVVVDYDHQSEF-FSNEQLIRYLAVMVNAANLRYRDLKSPRIRLLLVGITISKDPDFEPYIH----PINYGYIDA 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2015502074 256 KETLEDFNKQMKSKPFYYTSDIVFLVTGKNMSEWVDGKLQHWVGGYAYLGTACSEWRVGMSEDPPTSYYGAYVFAHELAH 335
Cdd:cd04272    76 AETLENFNEYVKKKRDYFNPDVVFLVTGLDMSTYSGGSLQTGTGGYAYVGGACTENRVAMGEDTPGSYYGVYTMTHELAH 155

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2015502074 336 NLGCQHDGDGPSDWVKGHIGSADCPWDDGYLMSYKMQDERQYKFSYCCQREVRNLYNRPEFKCLR 400
Cdd:cd04272   156 LLGAPHDGSPPPSWVKGHPGSLDCPWDDGYIMSYVVNGERQYRFSQCSQRQIRNVFRRLGASCLH 220
ZnMc_ADAM_like cd04267
Zinc-dependent metalloprotease, ADAM_like or reprolysin_like subgroup. The adamalysin_like or ...
 179-392 1.13e-19

Zinc-dependent metalloprotease, ADAM_like or reprolysin_like subgroup. The adamalysin_like or ADAM family of metalloproteases contains proteolytic domains from snake venoms, proteases from the mammalian reproductive tract, and the tumor necrosis factor alpha convertase, TACE. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions.


Pssm-ID: 239795  Cd Length: 192  Bit Score: 86.71  E-value: 1.13e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2015502074 179 EVHLVVDSTFASAFKFDVYKVTRYFAVLTNAANLRYASF-VFPKVQLRITGITMNKKPADEPYIhnvkgyekyrnilfke 257
Cdd:cd04267     4 ELVVVADHRMVSYFNSDENILQAYITELINIANSIYRSTnLRLGIRISLEGLQILKGEQFAPPI---------------- 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2015502074 258 tleDFNKQMKSKPFYYTS-------DIVFLVTGKNMsewVDGKLQhwvgGYAYLGTAC-SEWRVGMSEDPPTSYYGAYVF 329
Cdd:cd04267    68 ---DSDASNTLNSFSFWRaegpirhDNAVLLTAQDF---IEGDIL----GLAYVGSMCnPYSSVGVVEDTGFTLLTALTM 137

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2015502074 330 AHELAHNLGCQHDGDGPSdwvkghigSADCPWDDGYLMSYKMQDERQYKFSYCCQREVRNLYN 392
Cdd:cd04267   138 AHELGHNLGAEHDGGDEL--------AFECDGGGNYIMAPVDSGLNSYRFSQCSIGSIREFLD 192
Reprolysin_5 pfam13688
Metallo-peptidase family M12;
180-369 3.85e-15

Metallo-peptidase family M12;


Pssm-ID: 372673  Cd Length: 191  Bit Score: 73.61  E-value: 3.85e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2015502074 180 VHLVVDSTFASAFKFDVYKvTRYFAVLTNAANLRYASFvfpKVQLRITGITMNKKPADEPYIHNVKGYekyrnilFKETL 259
Cdd:pfam13688   7 LLVAADCSYVAAFGGDAAQ-ANIINMVNTASNVYERDF---NISLGLVNLTISDSTCPYTPPACSTGD-------SSDRL 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2015502074 260 EDFnkQMKSKP-FYYTSDIVFLVTGKNMSEwvdgklqhwvGGYAYLGTACSE-------WRVGMSEDPPTSYYGAYVFAH 331
Cdd:pfam13688  76 SEF--QDFSAWrGTQNDDLAYLFLMTNCSG----------GGLAWLGQLCNSgsagsvsTRVSGNNVVVSTATEWQVFAH 143

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 2015502074 332 ELAHNLGCQHDGDGPSDWVKGHIGSADCPWDDGYLMSY 369
Cdd:pfam13688 144 EIGHNFGAVHDCDSSTSSQCCPPSNSTCPAGGRYIMNP 181
ZnMc_adamalysin_II_like cd04269
Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom ...
 179-399 4.40e-12

Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions.


Pssm-ID: 239797 [Multi-domain]  Cd Length: 194  Bit Score: 64.94  E-value: 4.40e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2015502074 179 EVHLVVDSTFASAFKFDVYKVTRYFAVLTNAANLRYASFvfpKVQLRITGITM----NKKPADEPYIHNVKGYEKYRNil 254
Cdd:cd04269     4 ELVVVVDNSLYKKYGSNLSKVRQRVIEIVNIVDSIYRPL---NIRVVLVGLEIwtdkDKISVSGDAGETLNRFLDWKR-- 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2015502074 255 fketlEDFNKQMKSkpfyytsDIVFLVTGKNMSEWVDGKlqhwvggyAYLGTACS-EWRVGMSEDPPTSYYG-AYVFAHE 332
Cdd:cd04269    79 -----SNLLPRKPH-------DNAQLLTGRDFDGNTVGL--------AYVGGMCSpKYSGGVVQDHSRNLLLfAVTMAHE 138

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2015502074 333 LAHNLGCQHDGdgpsdwvkghiGSADCPwDDGYLMSYKMQDeRQYKFSYCCQREVRNLYNRPEFKCL 399
Cdd:cd04269   139 LGHNLGMEHDD-----------GGCTCG-RSTCIMAPSPSS-LTDAFSNCSYEDYQKFLSRGGGQCL 192
ZnMc cd00203
Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major ...
 245-391 4.79e-11

Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which are involved in vertebrate development and disease.


Pssm-ID: 238124 [Multi-domain]  Cd Length: 167  Bit Score: 61.38  E-value: 4.79e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2015502074 245 KGYEKYRNILFKETLEDFNKqmkskpfyytSDIVFLVTGKNMsewvDGKLqhwvGGYAYLGTACSEWRVGMS--EDPPTS 322
Cdd:cd00203    32 QIWRDYLNIRFVLVGVEIDK----------ADIAILVTRQDF----DGGT----GGWAYLGRVCDSLRGVGVlqDNQSGT 93

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2015502074 323 YYGAYVFAHELAHNLGCQHDGDG--PSDWVKGHIGSADCPWDDGYLMSY---KMQDERQYKFSYCCQREVRNLY 391
Cdd:cd00203    94 KEGAQTIAHELGHALGFYHDHDRkdRDDYPTIDDTLNAEDDDYYSVMSYtkgSFSDGQRKDFSQCDIDQINKLY 167
ZnMc_ADAMTS_like cd04273
Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) ...
 179-400 1.44e-10

Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that combine ADAM-like metalloproteinases with thrombospondin type-1 repeats. ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) proteinases are inhibited by TIMPs (tissue inhibitors of metalloproteinases), and they play roles in coagulation, angiogenesis, development and progression of arthritis. They hydrolyze the von Willebrand factor precursor and various components of the extracellular matrix.


Pssm-ID: 239801  Cd Length: 207  Bit Score: 60.72  E-value: 1.44e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2015502074 179 EVHLVVDSTFasafkFDVY---KVTRY-FAVLTNAANLRYASFVFPKVQLRITGITMNKKPADEPYI-HNVKgyekyrni 253
Cdd:cd04273     4 ETLVVADSKM-----VEFHhgeDLEHYiLTLMNIVASLYKDPSLGNSINIVVVRLIVLEDEESGLLIsGNAQ-------- 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2015502074 254 lfkETLEDF-------NKQMKSKPFYYtsDIVFLVTGKNmsewvdgkLQHWVG-----GYAYLGTACSEWR-VGMSEDpp 320
Cdd:cd04273    71 ---KSLKSFcrwqkklNPPNDSDPEHH--DHAILLTRQD--------ICRSNGncdtlGLAPVGGMCSPSRsCSINED-- 135

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2015502074 321 TSYYGAYVFAHELAHNLGCQHDGDGPSdwvkghigsadCP--WDDGYLMSYKMQ-DERQYKFSYCCQREVRNLYNRPEFK 397
Cdd:cd04273   136 TGLSSAFTIAHELGHVLGMPHDGDGNS-----------CGpeGKDGHIMSPTLGaNTGPFTWSKCSRRYLTSFLDTGDGN 204


                  ...
gi 2015502074 398 CLR 400
Cdd:cd04273   205 CLL 207
Reprolysin_3 pfam13582
Metallo-peptidase family M12B Reprolysin-like; This zinc-binding metallo-peptidase has the ...
 201-342 6.30e-08

Metallo-peptidase family M12B Reprolysin-like; This zinc-binding metallo-peptidase has the characteriztic binding motif HExxGHxxGxxH of Reprolysin-like peptidases of family M12B.


Pssm-ID: 463926 [Multi-domain]  Cd Length: 122  Bit Score: 51.22  E-value: 6.30e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2015502074 201 RYFAVLTNAANLRYASFVfpKVQLRITGITMNKkPADEPYIhnvkgyEKYRNILFKETLEDFNKQMKSkpfyYTSDIVFL 280
Cdd:pfam13582   1 ARIVSLVNRANTIYERDL--GIRLQLAAIIITT-SADTPYT------SSDALEILDELQEVNDTRIGQ----YGYDLGHL 67

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2015502074 281 VTGKNMSEwvdgklqhwVGGYAYLGTACSE-WRVGMSED-PPTSYYGAYVFAHELAHNLGCQHD 342
Cdd:pfam13582  68 FTGRDGGG---------GGGIAYVGGVCNSgSKFGVNSGsGPVGDTGADTFAHEIGHNFGLNHT 122
Reprolysin pfam01421
Reprolysin (M12B) family zinc metalloprotease; The members of this family are enzymes that ...
 257-399 1.06e-07

Reprolysin (M12B) family zinc metalloprotease; The members of this family are enzymes that cleave peptides. These proteases require zinc for catalysis. Members of this family are also known as adamalysins. Most members of this family are snake venom endopeptidases, but there are also some mammalian proteins such as Swiss:P78325, and fertilin. Fertilin and closely related proteins appear to not have some active site residues and may not be active enzymes.


Pssm-ID: 426256 [Multi-domain]  Cd Length: 200  Bit Score: 52.30  E-value: 1.06e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2015502074 257 ETLEDFNK-----QMKSKPFyytsDIVFLVTGKNmsewvdgkLQHWVGGYAYLGTACS-EWRVGMSEDPPTSYYG-AYVF 329
Cdd:pfam01421  68 DTLRNFLKwrqeyLKKRKPH----DVAQLLSGVE--------FGGTTVGAAYVGGMCSlEYSGGVNEDHSKNLESfAVTM 135

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2015502074 330 AHELAHNLGCQHDgdgpsdwvkGHIGSADCPWDDGYLMSYKMQDERQYKFSYCCQREVRNLYNRPEFKCL 399
Cdd:pfam01421 136 AHELGHNLGMQHD---------DFNGGCKCPPGGGCIMNPSAGSSFPRKFSNCSQEDFEQFLTKQKGACL 196
Salp15 pfam12115
Salivary protein of 15kDa inhibits CD4+ T cell activation; This is a family of 15kDa salivary ...
 438-483 2.09e-04

Salivary protein of 15kDa inhibits CD4+ T cell activation; This is a family of 15kDa salivary proteins from Acari Arachnids that is induced on feeding and assists the parasite to remain attached to its arthropod host. By repressing calcium fluxes triggered by TCR engagement, Salp15 inhibits CD4+ T cell activation. Salp15 shows weak similarity to Inhibin A, a member of the TGF-beta superfamily that inhibits the production of cytokines and the proliferation of T cells.


Pssm-ID: 314916  Cd Length: 112  Bit Score: 40.83  E-value: 2.09e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2015502074 438 DKTYGVRDCKVKCTGNTN------YWRLTvvDGTPCGK-KKACILGKCVNDIK 483
Cdd:pfam12115  60 DKLVDFKNCTFTCGKHNNggtnitLRQLP--DGTPCGPqGKTCKNGKCVGHVP 110
ADAMTS_CR_2 pfam17771
ADAMTS cysteine-rich domain 2; This cysteine rich domain is found in a variety of ADAMTS ...
 415-479 2.46e-04

ADAMTS cysteine-rich domain 2; This cysteine rich domain is found in a variety of ADAMTS peptidases (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) which is closely related to the ADAM family (pfam08516). Members of the ADAM-TS family have been implicated in a range of diseases. For instance, members of this family have been found to participate directly in processes in the central nervous system (CNS) such as the regulation of brain plasticity.


Pssm-ID: 465496  Cd Length: 68  Bit Score: 39.25  E-value: 2.46e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2015502074 415 PGRMTTLSNYCQRVY----RYEKGMHADktygvrDC-KVKCTGNTNYWRLTV----VDGTPCGKKKACILGKCV 479
Cdd:pfam17771   1 PGQLYSADEQCRLIFgpgsTFCPNGDED------VCsKLWCSNPGGSTCTTKnlpaADGTPCGNKKWCLNGKCV 68
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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