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Conserved domains on  [gi|1712980838|ref|XP_030013609|]
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peptide chain release factor 1, mitochondrial [Sphaeramia orbicularis]

Protein Classification

peptide chain release factor 1( domain architecture ID 1907968)

peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA

CATH:  3.30.160.20|3.30.70.1660|1.10.287.4000
Gene Ontology:  GO:0003747|GO:0016149
SCOP:  4002864|4002570

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PrfA super family cl43066
Protein chain release factor RF1 [Translation, ribosomal structure and biogenesis]; Protein ...
 64-427 3.47e-124

Protein chain release factor RF1 [Translation, ribosomal structure and biogenesis]; Protein chain release factor RF1 is part of the Pathway/BioSystem: Translation factors


The actual alignment was detected with superfamily member COG0216:

Pssm-ID: 439986 [Multi-domain]  Cd Length: 356  Bit Score: 364.71  E-value: 3.47e-124
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712980838  64 SVRRYLKQHMEEYTDLSEKL-QHACLSDSERKVMISK-HAKLLPLANIYQSIEQALKDLEEVLSLIHSaagskDEDKQLN 141
Cdd:COG0216     1 SMLDKLEALEERYEELEALLsDPEVISDQKRFRKLSKeYAELEPIVEAYREYKKLLEDIEEAKELLEE-----ESDPEMR 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712980838 142 QLLKEEEAEISKGILALRKDLIKALVPVDPLDSSNIMMEVVSGrtTGGD---IcqqFTREMFDMYEGFASYKNWDFEVLN 218
Cdd:COG0216    76 EMAKEELEELEARLEELEEELKILLLPKDPNDDKNVILEIRAG--TGGDeaaL---FAGDLFRMYSRYAERKGWKVEILS 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712980838 219 YTHAEFGGLHHAAVRIAGENVYRHLKHEGGTHRVQRIPEV---GlssrmqRIHTGTMTVIVLPQPTELDISIDQKDLRID 295
Cdd:COG0216   151 ASEGELGGYKEVIFRISGEGVYSRLKFESGVHRVQRVPETesqG------RIHTSAATVAVLPEAEEVDVEINPKDLRID 224

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712980838 296 TFRSRGAGGQSVNTTDSAVRIVHLPTGITAECQQSRSQLQNRDTAMRMLTARLYQSMMGKETEQRDTARKQQVRTRSQSD 375
Cdd:COG0216   225 TFRSSGAGGQHVNTTDSAVRITHLPTGIVVECQDERSQHKNKAKAMKVLRARLYEAEQQKQQAEIAAERKSQVGSGDRSE 304

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1712980838 376 RIRTYNFSQDRVTDHRTGYVTRDIKEFMRGGeaLGDLIsDVLEHAERESLLE 427
Cdd:COG0216   305 RIRTYNFPQGRVTDHRINLTLYKLDEVMEGD--LDELI-DALIAEDQAEKLA 353
 
Name Accession Description Interval E-value
PrfA COG0216
Protein chain release factor RF1 [Translation, ribosomal structure and biogenesis]; Protein ...
 64-427 3.47e-124

Protein chain release factor RF1 [Translation, ribosomal structure and biogenesis]; Protein chain release factor RF1 is part of the Pathway/BioSystem: Translation factors


Pssm-ID: 439986 [Multi-domain]  Cd Length: 356  Bit Score: 364.71  E-value: 3.47e-124
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712980838  64 SVRRYLKQHMEEYTDLSEKL-QHACLSDSERKVMISK-HAKLLPLANIYQSIEQALKDLEEVLSLIHSaagskDEDKQLN 141
Cdd:COG0216     1 SMLDKLEALEERYEELEALLsDPEVISDQKRFRKLSKeYAELEPIVEAYREYKKLLEDIEEAKELLEE-----ESDPEMR 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712980838 142 QLLKEEEAEISKGILALRKDLIKALVPVDPLDSSNIMMEVVSGrtTGGD---IcqqFTREMFDMYEGFASYKNWDFEVLN 218
Cdd:COG0216    76 EMAKEELEELEARLEELEEELKILLLPKDPNDDKNVILEIRAG--TGGDeaaL---FAGDLFRMYSRYAERKGWKVEILS 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712980838 219 YTHAEFGGLHHAAVRIAGENVYRHLKHEGGTHRVQRIPEV---GlssrmqRIHTGTMTVIVLPQPTELDISIDQKDLRID 295
Cdd:COG0216   151 ASEGELGGYKEVIFRISGEGVYSRLKFESGVHRVQRVPETesqG------RIHTSAATVAVLPEAEEVDVEINPKDLRID 224

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712980838 296 TFRSRGAGGQSVNTTDSAVRIVHLPTGITAECQQSRSQLQNRDTAMRMLTARLYQSMMGKETEQRDTARKQQVRTRSQSD 375
Cdd:COG0216   225 TFRSSGAGGQHVNTTDSAVRITHLPTGIVVECQDERSQHKNKAKAMKVLRARLYEAEQQKQQAEIAAERKSQVGSGDRSE 304

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1712980838 376 RIRTYNFSQDRVTDHRTGYVTRDIKEFMRGGeaLGDLIsDVLEHAERESLLE 427
Cdd:COG0216   305 RIRTYNFPQGRVTDHRINLTLYKLDEVMEGD--LDELI-DALIAEDQAEKLA 353
prfA PRK00591
peptide chain release factor 1; Validated
 69-430 7.72e-123

peptide chain release factor 1; Validated


Pssm-ID: 234801 [Multi-domain]  Cd Length: 359  Bit Score: 361.32  E-value: 7.72e-123
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712980838  69 LKQHMEEYTDLSEKL-QHACLSDSERKVMISK-HAKLLPLANIYQSIEQALKDLEEVLSLIHSaagskDEDKQLNQLLKE 146
Cdd:PRK00591    8 LEALEERYEELEALLsDPEVISDQKRFRKLSKeYAELEPIVEAYREYKQAQEDLEEAKEMLEE-----ESDPEMREMAKE 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712980838 147 EEAEISKGILALRKDLIKALVPVDPLDSSNIMMEVVSGrtTGGDICQQFTREMFDMYEGFASYKNWDFEVLNYTHAEFGG 226
Cdd:PRK00591   83 ELKELEERLEELEEELKILLLPKDPNDDKNVILEIRAG--TGGDEAALFAGDLFRMYSRYAERQGWKVEILSASEGELGG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712980838 227 LHHAAVRIAGENVYRHLKHEGGTHRVQRIPEV---GlssrmqRIHTGTMTVIVLPQPTELDISIDQKDLRIDTFRSRGAG 303
Cdd:PRK00591  161 YKEVIAEISGDGVYSKLKFESGVHRVQRVPATesqG------RIHTSAATVAVLPEAEEVEVEINPKDLRIDTFRSSGAG 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712980838 304 GQSVNTTDSAVRIVHLPTGITAECQQSRSQLQNRDTAMRMLTARLYQSMMGKETEQRDTARKQQVRTRSQSDRIRTYNFS 383
Cdd:PRK00591  235 GQHVNTTDSAVRITHLPTGIVVECQDERSQHKNKAKAMKVLRARLYDAERQKAQAEEAATRKSQVGSGDRSERIRTYNFP 314

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*..
gi 1712980838 384 QDRVTDHRTGYVTRDIKEFMRGgeALGDLISDVLEHAERESLLELVE 430
Cdd:PRK00591  315 QGRVTDHRINLTLYKLDEVMEG--DLDELIDALIAEDQAEKLAALGE 359
prfA TIGR00019
peptide chain release factor 1; This model describes peptide chain release factor 1 (PrfA, ...
 69-430 3.58e-105

peptide chain release factor 1; This model describes peptide chain release factor 1 (PrfA, RF-1), and excludes the related peptide chain release factor 2 (PrfB, RF-2). RF-1 helps recognize and terminate translation at UAA and UAG stop codons. The mitochondrial release factors are prfA-like, although not included above the trusted cutoff for this model. RF-1 does not have a translational frameshift. [Protein synthesis, Translation factors]


Pssm-ID: 129130 [Multi-domain]  Cd Length: 360  Bit Score: 316.25  E-value: 3.58e-105
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712980838  69 LKQHMEEYTDLSEKLQHACL-SDSERKVMISK-HAKLLPLANIYQSIEQALKDLEEVLSLIhsaagsKDEDKQLNQLLKE 146
Cdd:TIGR00019   9 LESLLERYEELEALLSDPEViSDQDKLRKLSKeYSQLEEIVDCYREYQQAQEDIKEAKEIL------EESDPEMREMAKE 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712980838 147 EEAEISKGILALRKDLIKALVPVDPLDSSNIMMEVVSGrtTGGDICQQFTREMFDMYEGFASYKNWDFEVLNYTHAEFGG 226
Cdd:TIGR00019  83 ELEELEEKIEELEEQLKVLLLPKDPNDEKNVILEIRAG--TGGDEAAIFAGDLFRMYSRYAESKGWKVEILSANETELGG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712980838 227 LHHAAVRIAGENVYRHLKHEGGTHRVQRIPEvglSSRMQRIHTGTMTVIVLPQPTELDISIDQKDLRIDTFRSRGAGGQS 306
Cdd:TIGR00019 161 YKEVIAEIKGDGVYSRLKFESGVHRVQRVPV---TESQGRIHTSAATVAVMPELEEVEVDINPADLRIDTFRSSGAGGQH 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712980838 307 VNTTDSAVRIVHLPTGITAECQQSRSQLQNRDTAMRMLTARLYQSMMGKETEQRDTARKQQVRTRSQSDRIRTYNFSQDR 386
Cdd:TIGR00019 238 VNTTDSAVRITHLPTGIVVECQDERSQHKNKDKAMKVLRARLYEAEQEKQQAAQASTRKSQVGSGDRSERIRTYNFPQNR 317

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....
gi 1712980838 387 VTDHRTGYVTRDIKEFMRGGEalgDLISDVLEHAERESLLELVE 430
Cdd:TIGR00019 318 VTDHRINLTLYKLDEVLEGDL---DELIEALIAEDQAQQLAALS 358
PCRF pfam03462
PCRF domain; This domain is found in peptide chain release factors.
 74-274 3.08e-57

PCRF domain; This domain is found in peptide chain release factors.


Pssm-ID: 460929 [Multi-domain]  Cd Length: 192  Bit Score: 186.82  E-value: 3.08e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712980838  74 EEYTDLSEKLQH-ACLSDSERKVMISK-HAKLLPLANIYQSIEQALKDLEEVLSLIhsaagskdEDKQLNQLLKEEEAEI 151
Cdd:pfam03462   3 ERYEELEALLSDpDVWDDQKRAQKLSKeYSELEPIVEAYREYKQALEDLEEAKELL--------EDPELAELAEEELEEL 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712980838 152 SKGILALRKDLIKALVPVDPLDSSNIMMEVVSGrtTGGDICQQFTREMFDMYEGFASYKNWDFEVLNYTHAEFGGLHHAA 231
Cdd:pfam03462  75 EKRLEELEEELKLLLLPKDPNDDKNAILEIRAG--AGGDEAALFAGDLFRMYTRYAERKGWKVEVLDYSETEAGGIKEAT 152

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1712980838 232 VRIAGENVYRHLKHEGGTHRVQRIPEvglSSRMQRIHTGTMTV 274
Cdd:pfam03462 153 FEISGEGAYGRLKFESGVHRVQRVPP---TESQGRIHTSFATV 192
PCRF smart00937
This domain is found in peptide chain release factors;
135-246 6.39e-32

This domain is found in peptide chain release factors;


Pssm-ID: 214923 [Multi-domain]  Cd Length: 116  Bit Score: 117.56  E-value: 6.39e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712980838  135 DEDKQLNQLLKEEEAEISKGILA-LRKDLIKALVPVDPLDSSNIMMEVVSGrtTGGDICQQFTREMFDMYEGFASYKNWD 213
Cdd:smart00937   6 EEDDEMRELAEEELEELEAELEEeLEELLKLLLLPKDPNDDKNAILEIRAG--AGGDEAALFAGDLLRMYLRYAERKGWK 83

                           90       100       110
                   ....*....|....*....|....*....|...
gi 1712980838  214 FEVLNYTHAEFGGLHHAAVRIAGENVYRHLKHE 246
Cdd:smart00937  84 VEVLDESEGELGGIKEATLKISGEGAYGKLKFE 116
 
Name Accession Description Interval E-value
PrfA COG0216
Protein chain release factor RF1 [Translation, ribosomal structure and biogenesis]; Protein ...
 64-427 3.47e-124

Protein chain release factor RF1 [Translation, ribosomal structure and biogenesis]; Protein chain release factor RF1 is part of the Pathway/BioSystem: Translation factors


Pssm-ID: 439986 [Multi-domain]  Cd Length: 356  Bit Score: 364.71  E-value: 3.47e-124
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712980838  64 SVRRYLKQHMEEYTDLSEKL-QHACLSDSERKVMISK-HAKLLPLANIYQSIEQALKDLEEVLSLIHSaagskDEDKQLN 141
Cdd:COG0216     1 SMLDKLEALEERYEELEALLsDPEVISDQKRFRKLSKeYAELEPIVEAYREYKKLLEDIEEAKELLEE-----ESDPEMR 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712980838 142 QLLKEEEAEISKGILALRKDLIKALVPVDPLDSSNIMMEVVSGrtTGGD---IcqqFTREMFDMYEGFASYKNWDFEVLN 218
Cdd:COG0216    76 EMAKEELEELEARLEELEEELKILLLPKDPNDDKNVILEIRAG--TGGDeaaL---FAGDLFRMYSRYAERKGWKVEILS 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712980838 219 YTHAEFGGLHHAAVRIAGENVYRHLKHEGGTHRVQRIPEV---GlssrmqRIHTGTMTVIVLPQPTELDISIDQKDLRID 295
Cdd:COG0216   151 ASEGELGGYKEVIFRISGEGVYSRLKFESGVHRVQRVPETesqG------RIHTSAATVAVLPEAEEVDVEINPKDLRID 224

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712980838 296 TFRSRGAGGQSVNTTDSAVRIVHLPTGITAECQQSRSQLQNRDTAMRMLTARLYQSMMGKETEQRDTARKQQVRTRSQSD 375
Cdd:COG0216   225 TFRSSGAGGQHVNTTDSAVRITHLPTGIVVECQDERSQHKNKAKAMKVLRARLYEAEQQKQQAEIAAERKSQVGSGDRSE 304

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1712980838 376 RIRTYNFSQDRVTDHRTGYVTRDIKEFMRGGeaLGDLIsDVLEHAERESLLE 427
Cdd:COG0216   305 RIRTYNFPQGRVTDHRINLTLYKLDEVMEGD--LDELI-DALIAEDQAEKLA 353
prfA PRK00591
peptide chain release factor 1; Validated
 69-430 7.72e-123

peptide chain release factor 1; Validated


Pssm-ID: 234801 [Multi-domain]  Cd Length: 359  Bit Score: 361.32  E-value: 7.72e-123
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712980838  69 LKQHMEEYTDLSEKL-QHACLSDSERKVMISK-HAKLLPLANIYQSIEQALKDLEEVLSLIHSaagskDEDKQLNQLLKE 146
Cdd:PRK00591    8 LEALEERYEELEALLsDPEVISDQKRFRKLSKeYAELEPIVEAYREYKQAQEDLEEAKEMLEE-----ESDPEMREMAKE 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712980838 147 EEAEISKGILALRKDLIKALVPVDPLDSSNIMMEVVSGrtTGGDICQQFTREMFDMYEGFASYKNWDFEVLNYTHAEFGG 226
Cdd:PRK00591   83 ELKELEERLEELEEELKILLLPKDPNDDKNVILEIRAG--TGGDEAALFAGDLFRMYSRYAERQGWKVEILSASEGELGG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712980838 227 LHHAAVRIAGENVYRHLKHEGGTHRVQRIPEV---GlssrmqRIHTGTMTVIVLPQPTELDISIDQKDLRIDTFRSRGAG 303
Cdd:PRK00591  161 YKEVIAEISGDGVYSKLKFESGVHRVQRVPATesqG------RIHTSAATVAVLPEAEEVEVEINPKDLRIDTFRSSGAG 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712980838 304 GQSVNTTDSAVRIVHLPTGITAECQQSRSQLQNRDTAMRMLTARLYQSMMGKETEQRDTARKQQVRTRSQSDRIRTYNFS 383
Cdd:PRK00591  235 GQHVNTTDSAVRITHLPTGIVVECQDERSQHKNKAKAMKVLRARLYDAERQKAQAEEAATRKSQVGSGDRSERIRTYNFP 314

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*..
gi 1712980838 384 QDRVTDHRTGYVTRDIKEFMRGgeALGDLISDVLEHAERESLLELVE 430
Cdd:PRK00591  315 QGRVTDHRINLTLYKLDEVMEG--DLDELIDALIAEDQAEKLAALGE 359
prfA TIGR00019
peptide chain release factor 1; This model describes peptide chain release factor 1 (PrfA, ...
 69-430 3.58e-105

peptide chain release factor 1; This model describes peptide chain release factor 1 (PrfA, RF-1), and excludes the related peptide chain release factor 2 (PrfB, RF-2). RF-1 helps recognize and terminate translation at UAA and UAG stop codons. The mitochondrial release factors are prfA-like, although not included above the trusted cutoff for this model. RF-1 does not have a translational frameshift. [Protein synthesis, Translation factors]


Pssm-ID: 129130 [Multi-domain]  Cd Length: 360  Bit Score: 316.25  E-value: 3.58e-105
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712980838  69 LKQHMEEYTDLSEKLQHACL-SDSERKVMISK-HAKLLPLANIYQSIEQALKDLEEVLSLIhsaagsKDEDKQLNQLLKE 146
Cdd:TIGR00019   9 LESLLERYEELEALLSDPEViSDQDKLRKLSKeYSQLEEIVDCYREYQQAQEDIKEAKEIL------EESDPEMREMAKE 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712980838 147 EEAEISKGILALRKDLIKALVPVDPLDSSNIMMEVVSGrtTGGDICQQFTREMFDMYEGFASYKNWDFEVLNYTHAEFGG 226
Cdd:TIGR00019  83 ELEELEEKIEELEEQLKVLLLPKDPNDEKNVILEIRAG--TGGDEAAIFAGDLFRMYSRYAESKGWKVEILSANETELGG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712980838 227 LHHAAVRIAGENVYRHLKHEGGTHRVQRIPEvglSSRMQRIHTGTMTVIVLPQPTELDISIDQKDLRIDTFRSRGAGGQS 306
Cdd:TIGR00019 161 YKEVIAEIKGDGVYSRLKFESGVHRVQRVPV---TESQGRIHTSAATVAVMPELEEVEVDINPADLRIDTFRSSGAGGQH 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712980838 307 VNTTDSAVRIVHLPTGITAECQQSRSQLQNRDTAMRMLTARLYQSMMGKETEQRDTARKQQVRTRSQSDRIRTYNFSQDR 386
Cdd:TIGR00019 238 VNTTDSAVRITHLPTGIVVECQDERSQHKNKDKAMKVLRARLYEAEQEKQQAAQASTRKSQVGSGDRSERIRTYNFPQNR 317

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....
gi 1712980838 387 VTDHRTGYVTRDIKEFMRGGEalgDLISDVLEHAERESLLELVE 430
Cdd:TIGR00019 318 VTDHRINLTLYKLDEVLEGDL---DELIEALIAEDQAQQLAALS 358
PCRF pfam03462
PCRF domain; This domain is found in peptide chain release factors.
 74-274 3.08e-57

PCRF domain; This domain is found in peptide chain release factors.


Pssm-ID: 460929 [Multi-domain]  Cd Length: 192  Bit Score: 186.82  E-value: 3.08e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712980838  74 EEYTDLSEKLQH-ACLSDSERKVMISK-HAKLLPLANIYQSIEQALKDLEEVLSLIhsaagskdEDKQLNQLLKEEEAEI 151
Cdd:pfam03462   3 ERYEELEALLSDpDVWDDQKRAQKLSKeYSELEPIVEAYREYKQALEDLEEAKELL--------EDPELAELAEEELEEL 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712980838 152 SKGILALRKDLIKALVPVDPLDSSNIMMEVVSGrtTGGDICQQFTREMFDMYEGFASYKNWDFEVLNYTHAEFGGLHHAA 231
Cdd:pfam03462  75 EKRLEELEEELKLLLLPKDPNDDKNAILEIRAG--AGGDEAALFAGDLFRMYTRYAERKGWKVEVLDYSETEAGGIKEAT 152

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1712980838 232 VRIAGENVYRHLKHEGGTHRVQRIPEvglSSRMQRIHTGTMTV 274
Cdd:pfam03462 153 FEISGEGAYGRLKFESGVHRVQRVPP---TESQGRIHTSFATV 192
RF-1 pfam00472
RF-1 domain; This domain is found in peptide chain release factors such as RF-1 and RF-2, and ...
 282-391 4.42e-53

RF-1 domain; This domain is found in peptide chain release factors such as RF-1 and RF-2, and a number of smaller proteins of unknown function. This domain contains the peptidyl-tRNA hydrolase activity. The domain contains a highly conserved motif GGQ, where the glutamine is thought to coordinate the water that mediates the hydrolysis.


Pssm-ID: 459823 [Multi-domain]  Cd Length: 111  Bit Score: 173.38  E-value: 4.42e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712980838 282 ELDISIDQKDLRIDTFRSRGAGGQSVNTTDSAVRIVHLPTGITAECQQSRSQLQNRDTAMRMLTARLYQsMMGKETEQRD 361
Cdd:pfam00472   2 EIEIEIDPKDLRIDTFRSSGAGGQHVNKTDSAVRLTHIPTGIVVKCQDERSQHQNREKALKRLRARLYE-LEEEKEEEKK 80

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1712980838 362 TARKQQVRTRSQSDRIRTYNFS-QDRVTDHR 391
Cdd:pfam00472  81 RRIKSQVGSGDRSEQIRTYNFKpQSRVKDHR 111
PRK08787 PRK08787
peptide chain release factor 2; Provisional
 123-405 4.93e-49

peptide chain release factor 2; Provisional


Pssm-ID: 136970 [Multi-domain]  Cd Length: 313  Bit Score: 169.84  E-value: 4.93e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712980838 123 VLSLIHSAAGSKDEDKQLNQLLKEEEAEISKGILAlrkDLIKALVPVDPL----------DSSNIMMEVVSGrtTGGDIC 192
Cdd:PRK08787    6 VIGIADVLSGLADAGELLDLAESEQDEDTALAVIA---DLDKYQAHVEKLefqrmfsgqmDGANAFVDIQAG--AGGTEA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712980838 193 QQFTREMFDMYEGFASYKNWDFEVLNYTHAEFGGLHHAAVRIAGENVYRHLKHEGGTHRVQRIPEVGLSSRMqriHTGTM 272
Cdd:PRK08787   81 QDWAEILLRMYLRWAESRGWKTELMEVSGGEVAGIKSATVRIEGEYAYGWLKTEIGVHRLVRKSPFDSDNRR---HTSFT 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712980838 273 TVIVLPQPTE-LDISIDQKDLRIDTFRSRGAGGQSVNTTDSAVRIVHLPTGITAECQQSRSQLQNRDTAMRMLTARLYQS 351
Cdd:PRK08787  158 SVFVSPEVDDnIEIDINPADLRTDVYRSSGAGGQHVNKTESAVRITHIPTNTVVACQTGRSQHQNRDNAMKMLAAKLYEL 237

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1712980838 352 MMGKETEQRDT--ARKQQVRTRSQsdrIRTYNFSQDRVTDHRTGYVTRDIKEFMRG 405
Cdd:PRK08787  238 EVQKRNAEKDAleATKSDIGWGSQ---IRNYVLDQSRIKDLRTGIERSDTQKVLDG 290
PRK05589 PRK05589
peptide chain release factor 2; Provisional
 111-405 3.37e-48

peptide chain release factor 2; Provisional


Pssm-ID: 235520 [Multi-domain]  Cd Length: 325  Bit Score: 167.67  E-value: 3.37e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712980838 111 QSIEQALKDLEEVLSLIHSAAGSKDEDKQLNQLLKEEEAEISKGILALRKDL--------IKALVPVDpLDSSNIMMEVV 182
Cdd:PRK05589   14 QEITSEEKYLKDKLDKYNHLRNRIEDIEVLCEMMSEEDDEMKKEIISEVKNIkeeidrfkIETLLSGE-YDRNNAILTLH 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712980838 183 SGrtTGGDICQQFTREMFDMYEGFASYKNWDFEVLNYTHAEFGGLHHAAVRIAGENVYRHLKHEGGTHRVQRIPEVGLSS 262
Cdd:PRK05589   93 SG--VGGTDAQDWTEMLLRMYTRWAEKKGYKVEIIDLLEGDEAGIKSVTLKITGEFAYGYLKAEKGIHRLVRISPFNANG 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712980838 263 RMQrihTGTMTVIVLPQPT-ELDISIDQKDLRIDTFRSRGAGGQSVNTTDSAVRIVHLPTGITAECQQSRSQLQNRDTAM 341
Cdd:PRK05589  171 KRQ---TSFASVEVLPELTdDQDIEIRSEDLKIDTYRAGGAGGQHVNKTESAVRITHIPTGIVVQCQNERSQHSNKETAM 247

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1712980838 342 RMLTARLYQ--SMMGKETEQRDTARKQQVRTRSQsdrIRTYNFSQ-DRVTDHRTGYVTRDIKEFMRG 405
Cdd:PRK05589  248 KMLKSKLVElkERAHKEKIEDLTGELKDMGWGSQ---IRSYVFHPyNLVKDHRTGVETSNVDSVMDG 311
PRK06746 PRK06746
peptide chain release factor 2; Provisional
 94-405 9.21e-42

peptide chain release factor 2; Provisional


Pssm-ID: 75726 [Multi-domain]  Cd Length: 326  Bit Score: 150.65  E-value: 9.21e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712980838  94 KVMISKHAKLLPLANIYQSIEQALKDLEEVLSLIHSaagSKDEDkqlnqLLKEEEAEIsKGILALRKDLIKALVPVDPLD 173
Cdd:PRK06746   14 QAVINEANALKDMVGKFRQLDETFENLEITHELLKE---EYDED-----LHEELESEV-KGLIQEMNEYELQLLLSDPYD 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712980838 174 SSNIMMEVVSGrtTGGDICQQFTREMFDMYEGFASYKNWDFEVLNYTHAEFGGLHHAAVRIAGENVYRHLKHEGGTHRVQ 253
Cdd:PRK06746   85 KNNAILELHPG--AGGTESQDWGSMLLRMYTRWAEKRGFKVETVDYLPGDEAGIKSVTLLIKGHNAYGYLKAEKGVHRLV 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712980838 254 RIPEVGLSSRMqriHTGTMTVIVLPQ-PTELDISIDQKDLRIDTFRSRGAGGQSVNTTDSAVRIVHLPTGITAECQQSRS 332
Cdd:PRK06746  163 RISPFDSSGRR---HTSFVSCEVVPEfNDEVEIEVRTEDLKIDTYRASGAGGQHVNTTDSAVRITHTPTNTVVTCQSERS 239

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1712980838 333 QLQNRDTAMRMLTARLYQSMMGKETEQRDTARKQQvRTRSQSDRIRTYNFSQ-DRVTDHRTGYVTRDIKEFMRG 405
Cdd:PRK06746  240 QIKNREHAMKMLKAKLYQKKLEEQQAELDEIRGEQ-KEIGWGSQIRSYVFHPySLVKDHRTNTEVGNVQAVMDG 312
PRK07342 PRK07342
peptide chain release factor 2; Provisional
 107-419 1.43e-41

peptide chain release factor 2; Provisional


Pssm-ID: 235997 [Multi-domain]  Cd Length: 339  Bit Score: 150.41  E-value: 1.43e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712980838 107 ANIYQSIEQALKDLEEVLSLIHSAAGSKDEDKQLN---QLLKEEEAEISKGILALRKDLIKALV------PVDPL----- 172
Cdd:PRK07342    6 PSLWNDAQEAQKLMRERQQLDDSINGINHLEQTLNdniELIAMGEEEGDKSIVEDAEKTIRDLKdeidrrQIDALlsgea 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712980838 173 DSSNIMMEVVSGrtTGGDICQQFTREMFDMYEGFASYKNWDFEVLNYTHAEFGGLHHAAVRIAGENVYRHLKHEGGTHRV 252
Cdd:PRK07342   86 DANDTYLEVHAG--AGGTESQDWASMLLRMYTRWAERQGRKVEVLEVHDGEEAGIKSATILVKGHNAYGWLKTESGVHRL 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712980838 253 QRIPEVGLSSRMqriHTGTMTVIVLPQPTE-LDISIDQKDLRIDTFRSRGAGGQSVNTTDSAVRIVHLPTGITAECQQSR 331
Cdd:PRK07342  164 VRISPYDSNARR---HTSFASIWVYPVIDDnIEVDVNESDVRIDTYRSSGAGGQHVNTTDSAVRITHIPTGIVVQCQQER 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712980838 332 SQLQNRDTAMRMLTARLYQSMMGKETEQRDTARKqqvrtrSQSD-----RIRTYNFSQDR-VTDHRTGYVTRDIKEFMRG 405
Cdd:PRK07342  241 SQHKNRAKAWSMLRARLYEEELKKREEATNAAAA------SKTDigwghQIRSYVLQPYQlVKDLRTGVESTNPQDVLDG 314

                         330
                  ....*....|....
gi 1712980838 406 geALGDLISDVLEH 419
Cdd:PRK07342  315 --DLNEFMEAALAH 326
PCRF smart00937
This domain is found in peptide chain release factors;
135-246 6.39e-32

This domain is found in peptide chain release factors;


Pssm-ID: 214923 [Multi-domain]  Cd Length: 116  Bit Score: 117.56  E-value: 6.39e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712980838  135 DEDKQLNQLLKEEEAEISKGILA-LRKDLIKALVPVDPLDSSNIMMEVVSGrtTGGDICQQFTREMFDMYEGFASYKNWD 213
Cdd:smart00937   6 EEDDEMRELAEEELEELEAELEEeLEELLKLLLLPKDPNDDKNAILEIRAG--AGGDEAALFAGDLLRMYLRYAERKGWK 83

                           90       100       110
                   ....*....|....*....|....*....|...
gi 1712980838  214 FEVLNYTHAEFGGLHHAAVRIAGENVYRHLKHE 246
Cdd:smart00937  84 VEVLDESEGELGGIKEATLKISGEGAYGKLKFE 116
PrfB COG1186
Protein chain release factor PrfB [Translation, ribosomal structure and biogenesis]; Protein ...
 284-391 1.00e-29

Protein chain release factor PrfB [Translation, ribosomal structure and biogenesis]; Protein chain release factor PrfB is part of the Pathway/BioSystem: Translation factors


Pssm-ID: 440799 [Multi-domain]  Cd Length: 140  Bit Score: 112.53  E-value: 1.00e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712980838 284 DISIDQKDLRIDTFRSRGAGGQSVNTTDSAVRIVH------------LPTGITAECQQSRSQLQNRDTAMRMLTARLYQS 351
Cdd:COG1186    20 EIEIPESDLRIDTYRASGAGGQNVNKVSSAVRLTHdiassslpdsrlTPGGIVVKAQEERSQHQNREDALKRLKALLYEA 99

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1712980838 352 MMGKETEQRDTARKQQVRTRSQSDRIRTynfsqdRVTDHR 391
Cdd:COG1186   100 ELEPKERRATKPTRGSKKRRLWGKQIRS------MVKDLR 133
release_prfH TIGR03072
putative peptide chain release factor H; Members of this protein family are bacterial proteins ...
 290-364 2.33e-16

putative peptide chain release factor H; Members of this protein family are bacterial proteins homologous to peptide chain release factors 1 (RF-1, product of the prfA gene), and 2 (RF-2, product of the prfB gene). The member from Escherichia coli K-12, designated prfH, appears to be a pseudogene. This class I release factor is always found as the downstream gene of a two-gene operon. [Protein synthesis, Translation factors]


Pssm-ID: 213768  Cd Length: 200  Bit Score: 77.12  E-value: 2.33e-16
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1712980838 290 KDLRIDTFRSRGAGGQSVNTTDSAVRIVHLPTGITAECQQSRSQLQNRDTAMRMLTARLYQSMMGKETEQRDTAR 364
Cdd:TIGR03072 106 DEIRFETLRSSGPGGQHVNKTESAVRATHLASGISVKVQSERSQHANKRLATLLLAVRLADLQQEQAAALRAERR 180
PRK09256 PRK09256
aminoacyl-tRNA hydrolase;
284-346 1.98e-08

aminoacyl-tRNA hydrolase;


Pssm-ID: 181730 [Multi-domain]  Cd Length: 138  Bit Score: 52.85  E-value: 1.98e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712980838 284 DISIDQKDLRIDTFRSRGAGGQSVNTTDSAVRIV------HLP------------TGITAE------CQQSRSQLQNRDT 339
Cdd:PRK09256    7 RLVIPENELEWRFIRASGPGGQNVNKVSTAVELRfdiaasSLPefykerllalagHRITKDgvivikAQEFRSQERNRED 86


                  ....*..
gi 1712980838 340 AMRMLTA 346
Cdd:PRK09256   87 ALERLVA 93
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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