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Conserved domains on  [gi|1717004861|ref|XP_030049250|]
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gastrula zinc finger protein XlCGF57.1-like [Microcaecilia unicolor]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 11577727)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development, and in regulating viral replication and transcription

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 12-51 4.99e-22

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


:

Pssm-ID: 143639  Cd Length: 40  Bit Score: 89.15  E-value: 4.99e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1717004861  12 VTFEDIAVSFSQEEWEYLDEGQKELYWEVMMENYETLISL 51
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
247-618 9.11e-10

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 61.25  E-value: 9.11e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717004861 247 RPFSCSDCGRNFVQKIHLTRHQKLHTGERPFSCFQ--CGKRFIQKIHLTRHQKRHIGEKPFSC--TECKKSFIRRDGLII 322
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNskSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717004861 323 HQKMHTGEKPFSCtqfekyiarkPHLSHHQNIHISDMP--WLMNESHSCYDMYqTNPFGEMAQD-----ETPLPCSEFEK 395
Cdd:COG5048   112 SSSSNSNDNNLLS----------SHSLPPSSRDPQLPDllSISNLRNNPLPGN-NSSSVNTPQSnslhpPLPANSLSKDP 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717004861 396 SlINKHMLIFGQKNPTGERPFQGSECSKYFFEKTNLRNHKKIHA-GERPFSCSECGKRFTQKMHLTRHQKIHTgeRPFSC 474
Cdd:COG5048   181 S-SNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSsSSLPLTTNSQLSPKSLLSQSPSSLSSSD--SSSSA 257

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717004861 475 SECGKCFISKERLIFHQNIHTG-------KRPFSCSICNKSFFEKTNLRKHQ--KIHTGE--RPFSCSE--CGKRFVQKT 541
Cdd:COG5048   258 SESPRSSLPTASSQSSSPNESDsssekgfSLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRND 337

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717004861 542 HLTRHEKIHTGEKPFSCSECERCFITKDML-------IFHQKIHTGEGLFSC--SKCNKTFMKKINFTRHQKRH-TGEPM 611
Cdd:COG5048   338 ALKRHILLHTSISPAKEKLLNSSSKFSPLLnneppqsLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHlSFRPY 417


                  ....*..
gi 1717004861 612 EQKTSPC 618
Cdd:COG5048   418 NCKNPPC 424
 
Name Accession Description Interval E-value
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 12-51 4.99e-22

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 89.15  E-value: 4.99e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1717004861  12 VTFEDIAVSFSQEEWEYLDEGQKELYWEVMMENYETLISL 51
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 12-52 4.21e-21

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 86.37  E-value: 4.21e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1717004861  12 VTFEDIAVSFSQEEWEYLDEGQKELYWEVMMENYETLISLG 52
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
12-55 2.87e-20

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 84.57  E-value: 2.87e-20
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1717004861   12 VTFEDIAVSFSQEEWEYLDEGQKELYWEVMMENYETLISLGDEV 55
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQV 44
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
247-618 9.11e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 61.25  E-value: 9.11e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717004861 247 RPFSCSDCGRNFVQKIHLTRHQKLHTGERPFSCFQ--CGKRFIQKIHLTRHQKRHIGEKPFSC--TECKKSFIRRDGLII 322
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNskSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717004861 323 HQKMHTGEKPFSCtqfekyiarkPHLSHHQNIHISDMP--WLMNESHSCYDMYqTNPFGEMAQD-----ETPLPCSEFEK 395
Cdd:COG5048   112 SSSSNSNDNNLLS----------SHSLPPSSRDPQLPDllSISNLRNNPLPGN-NSSSVNTPQSnslhpPLPANSLSKDP 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717004861 396 SlINKHMLIFGQKNPTGERPFQGSECSKYFFEKTNLRNHKKIHA-GERPFSCSECGKRFTQKMHLTRHQKIHTgeRPFSC 474
Cdd:COG5048   181 S-SNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSsSSLPLTTNSQLSPKSLLSQSPSSLSSSD--SSSSA 257

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717004861 475 SECGKCFISKERLIFHQNIHTG-------KRPFSCSICNKSFFEKTNLRKHQ--KIHTGE--RPFSCSE--CGKRFVQKT 541
Cdd:COG5048   258 SESPRSSLPTASSQSSSPNESDsssekgfSLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRND 337

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717004861 542 HLTRHEKIHTGEKPFSCSECERCFITKDML-------IFHQKIHTGEGLFSC--SKCNKTFMKKINFTRHQKRH-TGEPM 611
Cdd:COG5048   338 ALKRHILLHTSISPAKEKLLNSSSKFSPLLnneppqsLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHlSFRPY 417


                  ....*..
gi 1717004861 612 EQKTSPC 618
Cdd:COG5048   418 NCKNPPC 424
zf-H2C2_2 pfam13465
Zinc-finger double domain;
514-539 2.53e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 2.53e-04
                          10        20
                  ....*....|....*....|....*.
gi 1717004861 514 NLRKHQKIHTGERPFSCSECGKRFVQ 539
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 12-51 4.99e-22

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 89.15  E-value: 4.99e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1717004861  12 VTFEDIAVSFSQEEWEYLDEGQKELYWEVMMENYETLISL 51
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 12-52 4.21e-21

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 86.37  E-value: 4.21e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1717004861  12 VTFEDIAVSFSQEEWEYLDEGQKELYWEVMMENYETLISLG 52
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
12-55 2.87e-20

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 84.57  E-value: 2.87e-20
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1717004861   12 VTFEDIAVSFSQEEWEYLDEGQKELYWEVMMENYETLISLGDEV 55
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQV 44
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
247-618 9.11e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 61.25  E-value: 9.11e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717004861 247 RPFSCSDCGRNFVQKIHLTRHQKLHTGERPFSCFQ--CGKRFIQKIHLTRHQKRHIGEKPFSC--TECKKSFIRRDGLII 322
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNskSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717004861 323 HQKMHTGEKPFSCtqfekyiarkPHLSHHQNIHISDMP--WLMNESHSCYDMYqTNPFGEMAQD-----ETPLPCSEFEK 395
Cdd:COG5048   112 SSSSNSNDNNLLS----------SHSLPPSSRDPQLPDllSISNLRNNPLPGN-NSSSVNTPQSnslhpPLPANSLSKDP 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717004861 396 SlINKHMLIFGQKNPTGERPFQGSECSKYFFEKTNLRNHKKIHA-GERPFSCSECGKRFTQKMHLTRHQKIHTgeRPFSC 474
Cdd:COG5048   181 S-SNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSsSSLPLTTNSQLSPKSLLSQSPSSLSSSD--SSSSA 257

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717004861 475 SECGKCFISKERLIFHQNIHTG-------KRPFSCSICNKSFFEKTNLRKHQ--KIHTGE--RPFSCSE--CGKRFVQKT 541
Cdd:COG5048   258 SESPRSSLPTASSQSSSPNESDsssekgfSLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRND 337

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717004861 542 HLTRHEKIHTGEKPFSCSECERCFITKDML-------IFHQKIHTGEGLFSC--SKCNKTFMKKINFTRHQKRH-TGEPM 611
Cdd:COG5048   338 ALKRHILLHTSISPAKEKLLNSSSKFSPLLnneppqsLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHlSFRPY 417


                  ....*..
gi 1717004861 612 EQKTSPC 618
Cdd:COG5048   418 NCKNPPC 424
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
191-594 4.47e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 49.69  E-value: 4.47e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717004861 191 KSFPCGKCSKSFSHKEYLRKHQKIHTRERLFSCSK--CHESFFEKTTLRKHEKRHTGERPFSCSDCGR-NFVQKIHLTRH 267
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPlSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717004861 268 QKLHTGERPFSCFQCGKRFIQK--IHLTRHQKRHIGEKPFSctECKKSFIRRDG----LIIHQKMHTGEKPFSCTQFEKY 341
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRdpQLPDLLSISNLRNNPLP--GNNSSSVNTPQsnslHPPLPANSLSKDPSSNLSLLIS 189

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717004861 342 IARKPHLSHHQNI---HISDMPWLMNESHSCYDMYQTNPFGEMAQDETPLPCSEFEKSLINKHMLIfgQKNPTGERPFQG 418
Cdd:COG5048   190 SNVSTSIPSSSENsplSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSS--SASESPRSSLPT 267

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717004861 419 SECSKYFFEKTNLRNHKKIHAgerPFSCSECGKRFTQKMHLTRHQ--KIHTGE--RPFSCSE--CGKCFISKERLIFHQN 492
Cdd:COG5048   268 ASSQSSSPNESDSSSEKGFSL---PIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHIL 344

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717004861 493 IHTGKRPFSC--SICNKSFFEKTNLRKHQKIH-----TGERPFSC--SECGKRFVQKTHLTRHEKIHTGEKP--FSCSEC 561
Cdd:COG5048   345 LHTSISPAKEklLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPC 424

                         410       420       430
                  ....*....|....*....|....*....|...
gi 1717004861 562 ERCFITKDMLIFHQKIHTGEGLFSCSKCNKTFM 594
Cdd:COG5048   425 SKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRR 457
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
191-351 5.53e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.84  E-value: 5.53e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717004861 191 KSFPCGKCSKSFSHKEYLRKHQ--KIHTRERL--FSC--SKCHESFFEKTTLRKHEKRHTGERPFSCSDCGRNFVQKIHL 264
Cdd:COG5048   288 LPIKSKQCNISFSRSSPLTRHLrsVNHSGESLkpFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLL 367

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717004861 265 T-------RHQKLHTGERPFSC--FQCGKRFIQKIHLTRHQKRHIGEKP--FSCTECKKSFIRRDGLIIHQKMHTGEKPF 333
Cdd:COG5048   368 NneppqslQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPL 447

                         170
                  ....*....|....*...
gi 1717004861 334 SCTQFEKYIARkPHLSHH 351
Cdd:COG5048   448 LCSILKSFRRD-LDLSNH 464
zf-H2C2_2 pfam13465
Zinc-finger double domain;
514-539 2.53e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 2.53e-04
                          10        20
                  ....*....|....*....|....*.
gi 1717004861 514 NLRKHQKIHTGERPFSCSECGKRFVQ 539
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
458-483 1.39e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.39e-03
                          10        20
                  ....*....|....*....|....*.
gi 1717004861 458 HLTRHQKIHTGERPFSCSECGKCFIS 483
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
263-288 5.05e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 5.05e-03
                          10        20
                  ....*....|....*....|....*.
gi 1717004861 263 HLTRHQKLHTGERPFSCFQCGKRFIQ 288
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 444-466 6.23e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.58  E-value: 6.23e-03
                          10        20
                  ....*....|....*....|...
gi 1717004861 444 FSCSECGKRFTQKMHLTRHQKIH 466
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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