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Conserved domains on  [gi|1724784182|ref|XP_030274331|]
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ankyrin repeat and death domain-containing protein 1B isoform X2 [Sparus aurata]

Protein Classification

ankyrin repeat domain-containing protein( domain architecture ID 12356329)

ankyrin repeat (ANK) domain-containing protein mediate specific protein-protein interactions without necessarily recognizing specific primary sequences which allows for one ankyrin repeat domain to recognize and bind to a variety of intracellular substrates and may be involved in a wide array of functions

CATH:  1.25.40.20
Gene Ontology:  GO:0005515
PubMed:  33435370|15152081|17176038
SCOP:  4000366

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
65-339 4.93e-35

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 132.39  E-value: 4.93e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724784182  65 ILKSLVQAGAEQKVENEEGLNILHCAAINNHTEIVEYIVNDLQMKELDKEDRSGNRPFALAAEHGCAEMLdMLMEPYEMA 144
Cdd:COG0666     1 LLLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVA-LLLLAAGAD 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724784182 145 TMKPNKRGDTPLHLAARNDQLEAVQLLLQSLDTRDEVNMDGETALYQAADKGQERCVLALLEAGCDPNILTTAKCSALHP 224
Cdd:COG0666    80 INAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHL 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724784182 225 VSEKGDTSLVQLLLEYKAHTDFKNQHQEAPLHLAVKNSHIPVIYSLLKAGCDNNVTNKRSQTAMHLAAELGKIEVVEMLL 304
Cdd:COG0666   160 AAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLL 239

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1724784182 305 KAGLDLTLCDRQGKTALGVAARADEAIIVDMIIKA 339
Cdd:COG0666   240 EAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLA 274
Ank_2 pfam12796
Ankyrin repeats (3 copies);
21-104 4.49e-12

Ankyrin repeats (3 copies);


:

Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 62.06  E-value: 4.49e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724784182  21 LHYAVAGKNKDAMQFLLQRRVKVDQKDKHGVAPIHLAAWFGSLEILKSLVQAGaeQKVENEEGLNILHCAAINNHTEIVE 100
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHA--DVNLKDNGRTALHYAARSGHLEIVK 78


                  ....
gi 1724784182 101 YIVN 104
Cdd:pfam12796  79 LLLE 82
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
65-339 4.93e-35

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 132.39  E-value: 4.93e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724784182  65 ILKSLVQAGAEQKVENEEGLNILHCAAINNHTEIVEYIVNDLQMKELDKEDRSGNRPFALAAEHGCAEMLdMLMEPYEMA 144
Cdd:COG0666     1 LLLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVA-LLLLAAGAD 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724784182 145 TMKPNKRGDTPLHLAARNDQLEAVQLLLQSLDTRDEVNMDGETALYQAADKGQERCVLALLEAGCDPNILTTAKCSALHP 224
Cdd:COG0666    80 INAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHL 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724784182 225 VSEKGDTSLVQLLLEYKAHTDFKNQHQEAPLHLAVKNSHIPVIYSLLKAGCDNNVTNKRSQTAMHLAAELGKIEVVEMLL 304
Cdd:COG0666   160 AAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLL 239

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1724784182 305 KAGLDLTLCDRQGKTALGVAARADEAIIVDMIIKA 339
Cdd:COG0666   240 EAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLA 274
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 34-324 3.64e-16

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 81.26  E-value: 3.64e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724784182  34 QFLLQRRVKVDQKDKHGVAPIHLAAWFGSLEILKSLVQAGAEQKVENEEGLNILHCAAINNHTEIVEYIV--------ND 105
Cdd:PHA02876  162 EMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIIdnrsninkND 241

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724784182 106 LQ-MKELDKED--------RSG----------NRPFALAAEH-GCAEMLDMLMEPYEMATMKpNKRGDTPLHLAARND-Q 164
Cdd:PHA02876  242 LSlLKAIRNEDletslllyDAGfsvnsiddckNTPLHHASQApSLSRLVPKLLERGADVNAK-NIKGETPLYLMAKNGyD 320

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724784182 165 LEAVQLLLQSLDTRDEVNMDGETALYQAA--DKGQErCVLALLEAGCDPNILTTAKCSALHPVSEKGDTSLVQLLLEYKA 242
Cdd:PHA02876  321 TENIRTLIMLGADVNAADRLYITPLHQAStlDRNKD-IVITLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGA 399

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724784182 243 HTDFKNQHQEAPLHLAV--KNSHIPViYSLLKAGCDNNVTNKRSQTAMHLAAELG-KIEVVEMLLKAGLDLTLCDRQGKT 319
Cdd:PHA02876  400 DIEALSQKIGTALHFALcgTNPYMSV-KTLIDRGANVNSKNKDLSTPLHYACKKNcKLDVIEMLLDNGADVNAINIQNQY 478


                  ....*
gi 1724784182 320 ALGVA 324
Cdd:PHA02876  479 PLLIA 483
Ank_2 pfam12796
Ankyrin repeats (3 copies);
124-213 1.42e-15

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 72.07  E-value: 1.42e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724784182 124 LAAEHGCAEMLDMLMEpYEMATMKPNKRGDTPLHLAARNDQLEAVQLLLQSLDTRDevNMDGETALYQAADKGQERCVLA 203
Cdd:pfam12796   3 LAAKNGNLELVKLLLE-NGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNL--KDNGRTALHYAARSGHLEIVKL 79

                          90
                  ....*....|
gi 1724784182 204 LLEAGCDPNI 213
Cdd:pfam12796  80 LLEKGADINV 89
Ank_2 pfam12796
Ankyrin repeats (3 copies);
21-104 4.49e-12

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 62.06  E-value: 4.49e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724784182  21 LHYAVAGKNKDAMQFLLQRRVKVDQKDKHGVAPIHLAAWFGSLEILKSLVQAGaeQKVENEEGLNILHCAAINNHTEIVE 100
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHA--DVNLKDNGRTALHYAARSGHLEIVK 78


                  ....
gi 1724784182 101 YIVN 104
Cdd:pfam12796  79 LLLE 82
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
3-116 1.20e-11

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 65.36  E-value: 1.20e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724784182   3 MLGRGLNANAKNVDNRTALHYAVAGKNKDAMQFLLQRRVKVDQKDKHGVAPIHLAAWFGSLEILKSLVQAGAEQKVENEE 82
Cdd:COG0666   172 LLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKD 251

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1724784182  83 GLNILHCAAINNHTEIVEYIVNDLQMKELDKEDR 116
Cdd:COG0666   252 GLTALLLAAAAGAALIVKLLLLALLLLAAALLDL 285
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 4-104 7.89e-11

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 63.92  E-value: 7.89e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724784182   4 LGRGLNANAKNVDNRTALHYAVAGK--NKDAMQFLLQRRVKVDQKDK------HGV----------APIHLAAWFGSLEI 65
Cdd:PHA03100  128 LDNGANVNIKNSDGENLLHLYLESNkiDLKILKLLIDKGVDINAKNRvnyllsYGVpinikdvygfTPLHYAVYNNNPEF 207

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1724784182  66 LKSLVQAGAEQKVENEEGLNILHCAAINNHTEIVEYIVN 104
Cdd:PHA03100  208 VKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLN 246
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 111-305 7.09e-07

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 51.55  E-value: 7.09e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724784182 111 LDKEDRSGNRPFALAAEHGCAEMLDMLM-----EPYEMATMkpnkrGDTPLHLAARNDQLEAVQLLLQSldTRDEVNM-- 183
Cdd:cd22192    10 LLQQKRISESPLLLAAKENDVQAIKKLLkcpscDLFQRGAL-----GETALHVAALYDNLEAAVVLMEA--APELVNEpm 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724784182 184 -----DGETALYQAADKGQERCVLALLEAGCD---PNILTTA----KCSAL----HPVSEK---GDTSLVQLLLEykAHT 244
Cdd:cd22192    83 tsdlyQGETALHIAVVNQNLNLVRELIARGADvvsPRATGTFfrpgPKNLIyygeHPLSFAacvGNEEIVRLLIE--HGA 160

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1724784182 245 DFKNQHQ--EAPLH-LAVKNSHIPV--IYSLLKA-------GCDNNVTNKRSQTAMHLAAELGKIEVVEMLLK 305
Cdd:cd22192   161 DIRAQDSlgNTVLHiLVLQPNKTFAcqMYDLILSydkeddlQPLDLVPNNQGLTPFKLAAKEGNIVMFQHLVQ 233
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 19-173 3.57e-04

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 43.15  E-value: 3.57e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724784182  19 TALHYAVAGKNKDAMQFLLQRRVKVDQKDK--------------HGVAPIHLAAWFGSLEILKSLVQAGAEQKVENEEGL 84
Cdd:TIGR00870 130 TALHLAAHRQNYEIVKLLLERGASVPARACgdffvksqgvdsfyHGESPLNAAACLGSPSIVALLSEDPADILTADSLGN 209

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724784182  85 NILHCAAINNHTEiVEYIVNDLQMKEldkedrsgnrpFALaaehgcaEMLDMLMEPYEMATMkPNKRGDTPLHLAARNDQ 164
Cdd:TIGR00870 210 TLLHLLVMENEFK-AEYEELSCQMYN-----------FAL-------SLLDKLRDSKELEVI-LNHQGLTPLKLAAKEGR 269


                  ....*....
gi 1724784182 165 LEAVQLLLQ 173
Cdd:TIGR00870 270 IVLFRLKLA 278
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 151-174 9.76e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 33.72  E-value: 9.76e-03
                           10        20
                   ....*....|....*....|....
gi 1724784182  151 RGDTPLHLAARNDQLEAVQLLLQS 174
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDK 24
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
65-339 4.93e-35

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 132.39  E-value: 4.93e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724784182  65 ILKSLVQAGAEQKVENEEGLNILHCAAINNHTEIVEYIVNDLQMKELDKEDRSGNRPFALAAEHGCAEMLdMLMEPYEMA 144
Cdd:COG0666     1 LLLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVA-LLLLAAGAD 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724784182 145 TMKPNKRGDTPLHLAARNDQLEAVQLLLQSLDTRDEVNMDGETALYQAADKGQERCVLALLEAGCDPNILTTAKCSALHP 224
Cdd:COG0666    80 INAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHL 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724784182 225 VSEKGDTSLVQLLLEYKAHTDFKNQHQEAPLHLAVKNSHIPVIYSLLKAGCDNNVTNKRSQTAMHLAAELGKIEVVEMLL 304
Cdd:COG0666   160 AAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLL 239

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1724784182 305 KAGLDLTLCDRQGKTALGVAARADEAIIVDMIIKA 339
Cdd:COG0666   240 EAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLA 274
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
36-321 4.15e-30

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 118.90  E-value: 4.15e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724784182  36 LLQRRVKVDQKDKHGVAPIHLAAWFGSLEILKSLVQAGAEQKVENEEGLNILHCAAINNHTEIVEYIvnDLQMKELDKED 115
Cdd:COG0666     7 LLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLL--LAAGADINAKD 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724784182 116 RSGNRPFALAAEHGCAEMLDMLMEpYEMATMKPNKRGDTPLHLAARNDQLEAVQLLLQSLDTRDEVNMDGETALYQAADK 195
Cdd:COG0666    85 DGGNTLLHAAARNGDLEIVKLLLE-AGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAAN 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724784182 196 GQERCVLALLEAGCDPNILTTAKCSALHPVSEKGDTSLVQLLLEYKAHTDFKNQHQEAPLHLAVKNSHIPVIYSLLKAGC 275
Cdd:COG0666   164 GNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGA 243

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1724784182 276 DNNVTNKRSQTAMHLAAELGKIEVVEMLLKAGLDLTLCDRQGKTAL 321
Cdd:COG0666   244 DLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
4-288 3.69e-27

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 110.43  E-value: 3.69e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724784182   4 LGRGLNANAKNVDNRTALHYAVAGKNKDAMQFLLQRRVKVDQKDKHGVAPIHLAAWFGSLEILKSLVQAGAEQKVENEEG 83
Cdd:COG0666    41 LLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDG 120

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724784182  84 LNILHCAAINNHTEIVEYIVndlqmkeldkedrsgnrpfalaaEHGcAEMLdmlmepyematmKPNKRGDTPLHLAARND 163
Cdd:COG0666   121 ETPLHLAAYNGNLEIVKLLL-----------------------EAG-ADVN------------AQDNDGNTPLHLAAANG 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724784182 164 QLEAVQLLLQSLDTRDEVNMDGETALYQAADKGQERCVLALLEAGCDPNILTTAKCSALHPVSEKGDTSLVQLLLEYKAH 243
Cdd:COG0666   165 NLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGAD 244

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1724784182 244 TDFKNQHQEAPLHLAVKNSHIPVIYSLLKAGCDNNVTNKRSQTAM 288
Cdd:COG0666   245 LNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1-208 2.20e-26

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 108.50  E-value: 2.20e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724784182   1 MKMLGRGLNANAKNVDNRTALHYAVAGKNKDAMQFLLQRRVKVDQKDKHGVAPIHLAAWFGSLEILKSLVQAGAEQKVEN 80
Cdd:COG0666    71 LLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQD 150

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724784182  81 EEGLNILHCAAINNHTEIVEYIVNdlQMKELDKEDRSGNRPFALAAEHGCAEMLDMLMEpYEMATMKPNKRGDTPLHLAA 160
Cdd:COG0666   151 NDGNTPLHLAAANGNLEIVKLLLE--AGADVNARDNDGETPLHLAAENGHLEIVKLLLE-AGADVNAKDNDGKTALDLAA 227

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1724784182 161 RNDQLEAVQLLLQSLDTRDEVNMDGETALYQAADKGQERCVLALLEAG 208
Cdd:COG0666   228 ENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLAL 275
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 34-324 3.64e-16

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 81.26  E-value: 3.64e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724784182  34 QFLLQRRVKVDQKDKHGVAPIHLAAWFGSLEILKSLVQAGAEQKVENEEGLNILHCAAINNHTEIVEYIV--------ND 105
Cdd:PHA02876  162 EMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIIdnrsninkND 241

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724784182 106 LQ-MKELDKED--------RSG----------NRPFALAAEH-GCAEMLDMLMEPYEMATMKpNKRGDTPLHLAARND-Q 164
Cdd:PHA02876  242 LSlLKAIRNEDletslllyDAGfsvnsiddckNTPLHHASQApSLSRLVPKLLERGADVNAK-NIKGETPLYLMAKNGyD 320

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724784182 165 LEAVQLLLQSLDTRDEVNMDGETALYQAA--DKGQErCVLALLEAGCDPNILTTAKCSALHPVSEKGDTSLVQLLLEYKA 242
Cdd:PHA02876  321 TENIRTLIMLGADVNAADRLYITPLHQAStlDRNKD-IVITLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGA 399

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724784182 243 HTDFKNQHQEAPLHLAV--KNSHIPViYSLLKAGCDNNVTNKRSQTAMHLAAELG-KIEVVEMLLKAGLDLTLCDRQGKT 319
Cdd:PHA02876  400 DIEALSQKIGTALHFALcgTNPYMSV-KTLIDRGANVNSKNKDLSTPLHYACKKNcKLDVIEMLLDNGADVNAINIQNQY 478


                  ....*
gi 1724784182 320 ALGVA 324
Cdd:PHA02876  479 PLLIA 483
PHA03095 PHA03095
ankyrin-like protein; Provisional
 2-338 4.85e-16

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 80.07  E-value: 4.85e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724784182   2 KMLGRGLNANAKNVDNRTALHYAVA---GKNKDAMQFLLQRRVKVDQKDKHGVAPIHLAAWFGS-LEILKSLVQAGAEQK 77
Cdd:PHA03095   32 RLLAAGADVNFRGEYGKTPLHLYLHyssEKVKDIVRLLLEAGADVNAPERCGFTPLHLYLYNATtLDVIKLLIKAGADVN 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724784182  78 VENEEGLNILH--CAAINNHTEIVEYIVNdlqmKELDKEDRsgnrpfalaaehgcaemldmlmepyematmkpNKRGDTP 155
Cdd:PHA03095  112 AKDKVGRTPLHvyLSGFNINPKVIRLLLR----KGADVNAL--------------------------------DLYGMTP 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724784182 156 LH--LAARNDQLEAVQLLLQSLDTRDEVNMDGETALYQAAD--KGQERCVLALLEAGCDPNILTTAKCSALHpvsekgdt 231
Cdd:PHA03095  156 LAvlLKSRNANVELLRLLIDAGADVYAVDDRFRSLLHHHLQsfKPRARIVRELIRAGCDPAATDMLGNTPLH-------- 227

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724784182 232 slvqllleykahtdfknqhqEAPLHLAVKNShipVIYSLLKAGCDNNVTNKRSQTAMHLAAELGKIEVVEMLLKAGLDLT 311
Cdd:PHA03095  228 --------------------SMATGSSCKRS---LVLPLLIAGISINARNRYGQTPLHYAAVFNNPRACRRLIALGADIN 284

                         330       340
                  ....*....|....*....|....*..
gi 1724784182 312 LCDRQGKTALGVAARADEAIIVDMIIK 338
Cdd:PHA03095  285 AVSSDGNTPLSLMVRNNNGRAVRAALA 311
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 89-309 4.91e-16

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 80.04  E-value: 4.91e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724784182  89 CAAI-NNHTEIVEYIVNDLQMKELDKEDrsGNRPFALAAEHGCAEMLDMLMEPYEMATMK-PNKRgdTPLHLAARNDQLE 166
Cdd:PHA02875    7 CDAIlFGELDIARRLLDIGINPNFEIYD--GISPIKLAMKFRDSEAIKLLMKHGAIPDVKyPDIE--SELHDAVEEGDVK 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724784182 167 AVQLLLQSLDTRDEV-NMDGETALYQAADKGQERCVLALLEAGCDPNILTTAKCSALHPVSEKGDTSLVQLLLEYKAHTD 245
Cdd:PHA02875   83 AVEELLDLGKFADDVfYKDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACLD 162

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1724784182 246 FKNQHQEAPLHLAVKNSHIPVIYSLLKAGCDNNVTNKRSQ-TAMHLAAELGKIEVVEMLLKAGLD 309
Cdd:PHA02875  163 IEDCCGCTPLIIAMAKGDIAICKMLLDSGANIDYFGKNGCvAALCYAIENNKIDIVRLFIKRGAD 227
Ank_2 pfam12796
Ankyrin repeats (3 copies);
124-213 1.42e-15

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 72.07  E-value: 1.42e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724784182 124 LAAEHGCAEMLDMLMEpYEMATMKPNKRGDTPLHLAARNDQLEAVQLLLQSLDTRDevNMDGETALYQAADKGQERCVLA 203
Cdd:pfam12796   3 LAAKNGNLELVKLLLE-NGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNL--KDNGRTALHYAARSGHLEIVKL 79

                          90
                  ....*....|
gi 1724784182 204 LLEAGCDPNI 213
Cdd:pfam12796  80 LLEKGADINV 89
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 7-213 1.76e-15

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 78.17  E-value: 1.76e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724784182   7 GLNANAKNVDNRTALHY-----AVAGKNKDAMQFLLQRRVKVDQKDKHGVAPIHLAAW--FGSLEILKSLVQAGAEQKVE 79
Cdd:PHA03100   58 GADINSSTKNNSTPLHYlsnikYNLTDVKEIVKLLLEYGANVNAPDNNGITPLLYAISkkSNSYSIVEYLLDNGANVNIK 137

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724784182  80 NEEGLNILHCAAINNHTE------IVEYIVNdlqmkeLDKEDRsgnrpfalaaehgcaemLDMLMEpYEMATMKPNKRGD 153
Cdd:PHA03100  138 NSDGENLLHLYLESNKIDlkilklLIDKGVD------INAKNR-----------------VNYLLS-YGVPINIKDVYGF 193

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724784182 154 TPLHLAARNDQLEAVQLLLQSLDTRDEVNMDGETALYQAADKGQERCVLALLEAGcdPNI 213
Cdd:PHA03100  194 TPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNG--PSI 251
Ank_2 pfam12796
Ankyrin repeats (3 copies);
54-174 1.57e-14

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 68.99  E-value: 1.57e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724784182  54 IHLAAWFGSLEILKSLVQAGAEQKVENEEGLNILHCAAINNHTEIVEYIVndlqmkeldkedrsgnrpfalaaEHGCAEM 133
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLL-----------------------EHADVNL 57

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1724784182 134 LDmlmepyematmkpnkRGDTPLHLAARNDQLEAVQLLLQS 174
Cdd:pfam12796  58 KD---------------NGRTALHYAARSGHLEIVKLLLEK 83
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 21-324 5.35e-14

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 73.76  E-value: 5.35e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724784182  21 LHYAVAGKNKDAMQFLLQRRVKVDQKDKHGVAPIHLAAWFGSLEILKSLVQAGAEQKVENEEglNILHCAAINNHTEIV- 99
Cdd:PHA02878   41 LHQAVEARNLDVVKSLLTRGHNVNQPDHRDLTPLHIICKEPNKLGMKEMIRSINKCSVFYTL--VAIKDAFNNRNVEIFk 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724784182 100 ---------EYIVNDLQMKELDKEDRSGNRPFALAAEHGcAEMldmlmepyemaTMKPNKRGDTPLHLAARNDQLEAVQL 170
Cdd:PHA02878  119 iiltnryknIQTIDLVYIDKKSKDDIIEAEITKLLLSYG-ADI-----------NMKDRHKGNTALHYATENKDQRLTEL 186

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724784182 171 LLqsldtrdevnmdgetaLYqaadkgqercvlalleaGCDPNILTTAKCSALHPVSEKGDTSLVQLLLEYKAHTDFKNQH 250
Cdd:PHA02878  187 LL----------------SY-----------------GANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKC 233

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1724784182 251 QEAPLHLAVKN-SHIPVIYSLLKAGCDNNVTNK-RSQTAMHLAaeLGKIEVVEMLLKAGLDLTLCDRQGKTALGVA 324
Cdd:PHA02878  234 GNTPLHISVGYcKDYDILKLLLEHGVDVNAKSYiLGLTALHSS--IKSERKLKLLLEYGADINSLNSYKLTPLSSA 307
Ank_2 pfam12796
Ankyrin repeats (3 copies);
189-281 3.63e-13

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 65.14  E-value: 3.63e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724784182 189 LYQAADKGQERCVLALLEAGCDPNILTTAKCSALHPVSEKGDTSLVQLLLEYkAHTDFKNqHQEAPLHLAVKNSHIPVIY 268
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKD-NGRTALHYAARSGHLEIVK 78

                          90
                  ....*....|...
gi 1724784182 269 SLLKAGCDNNVTN 281
Cdd:pfam12796  79 LLLEKGADINVKD 91
Ank_2 pfam12796
Ankyrin repeats (3 copies);
222-312 4.96e-13

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 64.75  E-value: 4.96e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724784182 222 LHPVSEKGDTSLVQLLLEYKAHTDFKNQHQEAPLHLAVKNSHIPVIYSLLKAGCDNNVTNKRsqTAMHLAAELGKIEVVE 301
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNLKDNGR--TALHYAARSGHLEIVK 78

                          90
                  ....*....|.
gi 1724784182 302 MLLKAGLDLTL 312
Cdd:pfam12796  79 LLLEKGADINV 89
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 119-338 8.87e-13

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 69.69  E-value: 8.87e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724784182 119 NRPFALAAEHGCAEMLDMLMEPYEMATMkpnkrgdtPLHLAARNDQLEAVQLLL-QSLDTrDEVNMDGETAL-YQAADKG 196
Cdd:PHA03100   10 SRIIKVKNIKYIIMEDDLNDYSYKKPVL--------PLYLAKEARNIDVVKILLdNGADI-NSSTKNNSTPLhYLSNIKY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724784182 197 QERCVLA----LLEAGCDPNILTTAKCSALHPVSEK--GDTSLVQLLLEYKAHTDFKNQHQEAPLHLAVKNSHIPV---- 266
Cdd:PHA03100   81 NLTDVKEivklLLEYGANVNAPDNNGITPLLYAISKksNSYSIVEYLLDNGANVNIKNSDGENLLHLYLESNKIDLkilk 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724784182 267 --------------IYSLLKAGCDNNVTNKRSQTAMHLAAELGKIEVVEMLLKAGLDLTLCDRQGKTALGVAARADEAII 332
Cdd:PHA03100  161 llidkgvdinaknrVNYLLSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEI 240


                  ....*.
gi 1724784182 333 VDMIIK 338
Cdd:PHA03100  241 FKLLLN 246
Ank_2 pfam12796
Ankyrin repeats (3 copies);
21-104 4.49e-12

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 62.06  E-value: 4.49e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724784182  21 LHYAVAGKNKDAMQFLLQRRVKVDQKDKHGVAPIHLAAWFGSLEILKSLVQAGaeQKVENEEGLNILHCAAINNHTEIVE 100
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHA--DVNLKDNGRTALHYAARSGHLEIVK 78


                  ....
gi 1724784182 101 YIVN 104
Cdd:pfam12796  79 LLLE 82
Ank_2 pfam12796
Ankyrin repeats (3 copies);
255-338 6.08e-12

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 61.67  E-value: 6.08e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724784182 255 LHLAVKNSHIPVIYSLLKAGCDNNVTNKRSQTAMHLAAELGKIEVVEMLLKAGlDLTLCDrQGKTALGVAARADEAIIVD 334
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHA-DVNLKD-NGRTALHYAARSGHLEIVK 78


                  ....
gi 1724784182 335 MIIK 338
Cdd:pfam12796  79 LLLE 82
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 3-271 1.01e-11

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 66.53  E-value: 1.01e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724784182   3 MLGRGLNANAKNVDNRTALHYAVAGKNKDAMQFLLQRRVKVDQKDKHGVAPIHLAAWFGSLEILKSLVQAGAEQKVENEE 82
Cdd:PHA02874  110 ILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNN 189

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724784182  83 GLNILHCAAINNHTEIVEYIVNDlqmkeldkedrsGNRpfalaaehgcaemldmlmepyemaTMKPNKRGDTPLHLAARN 162
Cdd:PHA02874  190 GESPLHNAAEYGDYACIKLLIDH------------GNH------------------------IMNKCKNGFTPLHNAIIH 233

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724784182 163 DQlEAVQLLLQSLDTRDEvNMDGETALYQAadkgqercvlalLEAGCDPNIlttakcsalhpvsekgdtslVQLLLEYKA 242
Cdd:PHA02874  234 NR-SAIELLINNASINDQ-DIDGSTPLHHA------------INPPCDIDI--------------------IDILLYHKA 279

                         250       260       270
                  ....*....|....*....|....*....|
gi 1724784182 243 HTDFKNQHQEAPLHLAVKN-SHIPVIYSLL 271
Cdd:PHA02874  280 DISIKDNKGENPIDTAFKYiNKDPVIKDII 309
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
3-116 1.20e-11

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 65.36  E-value: 1.20e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724784182   3 MLGRGLNANAKNVDNRTALHYAVAGKNKDAMQFLLQRRVKVDQKDKHGVAPIHLAAWFGSLEILKSLVQAGAEQKVENEE 82
Cdd:COG0666   172 LLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKD 251

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1724784182  83 GLNILHCAAINNHTEIVEYIVNDLQMKELDKEDR 116
Cdd:COG0666   252 GLTALLLAAAAGAALIVKLLLLALLLLAAALLDL 285
Ank_2 pfam12796
Ankyrin repeats (3 copies);
156-248 6.07e-11

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 58.59  E-value: 6.07e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724784182 156 LHLAARNDQLEAVQLLLQSLDTRDEVNMDGETALYQAADKGQERCVLALLEaGCDPNIlTTAKCSALHPVSEKGDTSLVQ 235
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLE-HADVNL-KDNGRTALHYAARSGHLEIVK 78

                          90
                  ....*....|...
gi 1724784182 236 LLLEYKAHTDFKN 248
Cdd:pfam12796  79 LLLEKGADINVKD 91
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 154-324 6.71e-11

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 64.21  E-value: 6.71e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724784182 154 TPLHLAARNDQLEAVQLLLQSLDTRDEVNMDGETALYQAADKGQERCVLALLEAGCDPNIL-----------TTAKC--- 219
Cdd:PHA02874   37 TPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLIDNGVDTSILpipciekdmikTILDCgid 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724784182 220 ---------SALHPVSEKGDTSLVQLLLEYKAHTDFKNQHQEAPLHLAVKNSHIPVIYSLLKAGCDNNVTNKRSQTAMHL 290
Cdd:PHA02874  117 vnikdaelkTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHN 196

                         170       180       190
                  ....*....|....*....|....*....|....
gi 1724784182 291 AAELGKIEVVEMLLKAGLDLTLCDRQGKTALGVA 324
Cdd:PHA02874  197 AAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNA 230
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 4-104 7.89e-11

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 63.92  E-value: 7.89e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724784182   4 LGRGLNANAKNVDNRTALHYAVAGK--NKDAMQFLLQRRVKVDQKDK------HGV----------APIHLAAWFGSLEI 65
Cdd:PHA03100  128 LDNGANVNIKNSDGENLLHLYLESNkiDLKILKLLIDKGVDINAKNRvnyllsYGVpinikdvygfTPLHYAVYNNNPEF 207

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1724784182  66 LKSLVQAGAEQKVENEEGLNILHCAAINNHTEIVEYIVN 104
Cdd:PHA03100  208 VKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLN 246
Ank_2 pfam12796
Ankyrin repeats (3 copies);
3-80 1.38e-09

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 54.74  E-value: 1.38e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1724784182   3 MLGRGLNANAKNVDNRTALHYAVAGKNKDAMQFLLQrRVKVDQKDkHGVAPIHLAAWFGSLEILKSLVQAGAEQKVEN 80
Cdd:pfam12796  16 LLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLE-HADVNLKD-NGRTALHYAARSGHLEIVKLLLEKGADINVKD 91
PHA03095 PHA03095
ankyrin-like protein; Provisional
 3-229 2.03e-09

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 59.65  E-value: 2.03e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724784182   3 MLGRGLNANAKNVDNRTALHYAVAGKN--KDAMQFLLQRRVKVDQKDKHGVAPIHLAAWFG--SLEILKSLVQAGAEQKV 78
Cdd:PHA03095  103 LIKAGADVNAKDKVGRTPLHVYLSGFNinPKVIRLLLRKGADVNALDLYGMTPLAVLLKSRnaNVELLRLLIDAGADVYA 182

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724784182  79 ENEEGLNILHCAAINNHTEivEYIVNDLQMKELD--KEDRSGNRPFALAAEHGCAEMLDMLmePYEMATM---KPNKRGD 153
Cdd:PHA03095  183 VDDRFRSLLHHHLQSFKPR--ARIVRELIRAGCDpaATDMLGNTPLHSMATGSSCKRSLVL--PLLIAGIsinARNRYGQ 258

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1724784182 154 TPLHLAARNDQLEAVQLLLQ---SLDTRDEvnmDGETALYQAADKGQERCVLALLEAgcDPNILTTAKcsALHPVSEKG 229
Cdd:PHA03095  259 TPLHYAAVFNNPRACRRLIAlgaDINAVSS---DGNTPLSLMVRNNNGRAVRAALAK--NPSAETVAA--TLNTASVAG 330
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 210-305 5.95e-09

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 58.37  E-value: 5.95e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724784182 210 DPNI---LTTAKCSalhpVSEKGDTSLVQLLLEYKAHTDFKNQHQEAPLHLAVKNSHIPVIYSLLKAGCDNNVTNKRSQT 286
Cdd:PTZ00322   75 DPVVahmLTVELCQ----LAASGDAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKT 150

                          90
                  ....*....|....*....
gi 1724784182 287 AMHLAAELGKIEVVEMLLK 305
Cdd:PTZ00322  151 PLELAEENGFREVVQLLSR 169
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 210-337 1.61e-08

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 57.19  E-value: 1.61e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724784182 210 DPNILTtakcsalhpVSEKGDTSLVQLLLEYKAHTDFKNQHQEAPLHLAVKNSHIPVIYSLLKAGCDNNVTNKRSQTAM- 288
Cdd:PLN03192  526 ASNLLT---------VASTGNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALw 596

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1724784182 289 ------H------------------------LAAELGKIEVVEMLLKAGLDLTLCDRQGKTALGVAARADEAIIVDMII 337
Cdd:PLN03192  597 naisakHhkifrilyhfasisdphaagdllcTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLI 675
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 11-173 5.11e-08

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 55.00  E-value: 5.11e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724784182  11 NAKNVDNRTALHYAVA-GKNKDAMQFLLQRRVKVDQKDKHGVAPIHLAAWFGSLEILKSLVQAGAEQKVENEEGLNILHC 89
Cdd:PHA02875   62 DVKYPDIESELHDAVEeGDVKAVEELLDLGKFADDVFYKDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHL 141

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724784182  90 AAINNHTEIVEYIVNdlQMKELDKEDRSGNRPFALAAEHGCAEMLDMLMEpyemATMKPN---KRGD-TPLHLAARNDQL 165
Cdd:PHA02875  142 AVMMGDIKGIELLID--HKACLDIEDCCGCTPLIIAMAKGDIAICKMLLD----SGANIDyfgKNGCvAALCYAIENNKI 215


                  ....*...
gi 1724784182 166 EAVQLLLQ 173
Cdd:PHA02875  216 DIVRLFIK 223
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 270-338 6.34e-08

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 55.29  E-value: 6.34e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1724784182 270 LLKAGCDNNVTNKRSQTAMHLAAELGKIEVVEMLLKAGLDLTLCDRQGKTALGVAARADEAIIVDMIIK 338
Cdd:PTZ00322  101 LLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSR 169
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 204-338 1.36e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 53.46  E-value: 1.36e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724784182 204 LLEAGCDPNILTTAKCSALHPVSEKGDTSLVQLLLEYKAHTDFKNQHQEAPLHLAVKNSHIPVIYSLLKAGC-DNNVTNK 282
Cdd:PHA02875   21 LLDIGINPNFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVKAVEELLDLGKfADDVFYK 100

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1724784182 283 RSQTAMHLAAELGKIEVVEMLLKAGLDLTLCDRQGKTALGVAARADEAIIVDMIIK 338
Cdd:PHA02875  101 DGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLID 156
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 229-358 1.46e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 53.43  E-value: 1.46e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724784182 229 GDTSLVQLLLEYKAHTDFKNQHQEAPLHLAVK----------------NSHIPV-------IYSLLKAGCDNNVTNKRSQ 285
Cdd:PHA02874   46 GDAKIVELFIKHGADINHINTKIPHPLLTAIKigahdiikllidngvdTSILPIpciekdmIKTILDCGIDVNIKDAELK 125

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1724784182 286 TAMHLAAELGKIEVVEMLLKAGLDLTLCDRQGKTALGVAARADEAIIVDMIIKAERYYawRTSNPELNDSLHN 358
Cdd:PHA02874  126 TFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYA--NVKDNNGESPLHN 196
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 185-311 3.67e-07

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 52.95  E-value: 3.67e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724784182 185 GETALYQAADKGQERCVLALLEAGCDPNILTTAKCSALHPVSEKGDTSLVQLLLEYKAHTDfkNQHQEAPLHLAVKNSHI 264
Cdd:PLN03192  558 GRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHKIFRILYHFASISD--PHAAGDLLCTAAKRNDL 635

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1724784182 265 PVIYSLLKAGCDNNVTNKRSQTAMHLAAELGKIEVVEMLLKAGLDLT 311
Cdd:PLN03192  636 TAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGADVD 682
Ank_5 pfam13857
Ankyrin repeats (many copies);
270-324 6.52e-07

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 46.19  E-value: 6.52e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1724784182 270 LLKAG-CDNNVTNKRSQTAMHLAAELGKIEVVEMLLKAGLDLTLCDRQGKTALGVA 324
Cdd:pfam13857   1 LLEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 111-305 7.09e-07

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 51.55  E-value: 7.09e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724784182 111 LDKEDRSGNRPFALAAEHGCAEMLDMLM-----EPYEMATMkpnkrGDTPLHLAARNDQLEAVQLLLQSldTRDEVNM-- 183
Cdd:cd22192    10 LLQQKRISESPLLLAAKENDVQAIKKLLkcpscDLFQRGAL-----GETALHVAALYDNLEAAVVLMEA--APELVNEpm 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724784182 184 -----DGETALYQAADKGQERCVLALLEAGCD---PNILTTA----KCSAL----HPVSEK---GDTSLVQLLLEykAHT 244
Cdd:cd22192    83 tsdlyQGETALHIAVVNQNLNLVRELIARGADvvsPRATGTFfrpgPKNLIyygeHPLSFAacvGNEEIVRLLIE--HGA 160

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1724784182 245 DFKNQHQ--EAPLH-LAVKNSHIPV--IYSLLKA-------GCDNNVTNKRSQTAMHLAAELGKIEVVEMLLK 305
Cdd:cd22192   161 DIRAQDSlgNTVLHiLVLQPNKTFAcqMYDLILSydkeddlQPLDLVPNNQGLTPFKLAAKEGNIVMFQHLVQ 233
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 5-195 1.20e-06

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 50.65  E-value: 1.20e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724784182   5 GRGLNANAKNVDNrTALHYAVAGKNKDAMQFLLQRRVKVDQKDKHGVAPIHLAAWFGSLEILKSLVQAGAEQKVENEEGL 84
Cdd:PHA02878  157 GADINMKDRHKGN-TALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGN 235

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724784182  85 NILHCAainnhteiVEYIVNdlqmkeldkedrsgnrpfalaaehgcAEMLDMLMEPYEMATMKPNKRGDTPLHLAARNDQ 164
Cdd:PHA02878  236 TPLHIS--------VGYCKD--------------------------YDILKLLLEHGVDVNAKSYILGLTALHSSIKSER 281

                         170       180       190
                  ....*....|....*....|....*....|.
gi 1724784182 165 leAVQLLLQSLDTRDEVNMDGETALYQAADK 195
Cdd:PHA02878  282 --KLKLLLEYGADINSLNSYKLTPLSSAVKQ 310
Ank_4 pfam13637
Ankyrin repeats (many copies);
17-70 1.55e-06

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 44.96  E-value: 1.55e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1724784182  17 NRTALHYAVAGKNKDAMQFLLQRRVKVDQKDKHGVAPIHLAAWFGSLEILKSLV 70
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 3-103 2.11e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 49.99  E-value: 2.11e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724784182   3 MLGRGLNANAKNVDNRTALHYAVAGKNKDAMQFLLQRRVKVDQKDKHGVAPIHLAAWFGSLEILKSLVQAGAEQKVENEE 82
Cdd:PHA02875  121 LIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANIDYFGKN 200

                          90       100
                  ....*....|....*....|..
gi 1724784182  83 GLNILHCAAI-NNHTEIVEYIV 103
Cdd:PHA02875  201 GCVAALCYAIeNNKIDIVRLFI 222
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 19-174 3.16e-06

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 49.63  E-value: 3.16e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724784182  19 TALHYAVAGKNKDAMQFLLQRRVKVD---------QKDKH-----GVAPIHLAAWFGSLEILKSLVQAGAEQKVENEEGL 84
Cdd:cd22192    91 TALHIAVVNQNLNLVRELIARGADVVspratgtffRPGPKnliyyGEHPLSFAACVGNEEIVRLLIEHGADIRAQDSLGN 170

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724784182  85 NILHCAAINNHTEIVEYIVnDLQMKeLDKEDRSGNrpfalaaehgcaemLDMLmepyematmkPNKRGDTPLHLAARNDQ 164
Cdd:cd22192   171 TVLHILVLQPNKTFACQMY-DLILS-YDKEDDLQP--------------LDLV----------PNNQGLTPFKLAAKEGN 224

                         170
                  ....*....|
gi 1724784182 165 LEAVQLLLQS 174
Cdd:cd22192   225 IVMFQHLVQK 234
Ank_4 pfam13637
Ankyrin repeats (many copies);
254-304 7.66e-06

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 43.03  E-value: 7.66e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1724784182 254 PLHLAVKNSHIPVIYSLLKAGCDNNVTNKRSQTAMHLAAELGKIEVVEMLL 304
Cdd:pfam13637   4 ALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
Ank_4 pfam13637
Ankyrin repeats (many copies);
53-101 7.89e-06

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 43.03  E-value: 7.89e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1724784182  53 PIHLAAWFGSLEILKSLVQAGAEQKVENEEGLNILHCAAINNHTEIVEY 101
Cdd:pfam13637   4 ALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKL 52
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 131-321 9.42e-06

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 48.09  E-value: 9.42e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724784182 131 AEMLDmlmEPYEMATMKPNkrgDTPLHLAARNDQLEAVQLLLQSLDT----RDEVnmdGETALYQAADKGQERCVLALLE 206
Cdd:cd22192     2 AQMLD---ELHLLQQKRIS---ESPLLLAAKENDVQAIKKLLKCPSCdlfqRGAL---GETALHVAALYDNLEAAVVLME 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724784182 207 agCDPNILTTAKCSALHpvseKGDTslvqllleykahtdfknqhqeaPLHLAVKNSHIPVIYSLLKAGCDnnVTNKRSQ- 285
Cdd:cd22192    73 --AAPELVNEPMTSDLY----QGET----------------------ALHIAVVNQNLNLVRELIARGAD--VVSPRATg 122

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1724784182 286 TAMHL---------------AAELGKIEVVEMLLKAGLDLTLCDRQGKTAL 321
Cdd:cd22192   123 TFFRPgpknliyygehplsfAACVGNEEIVRLLIEHGADIRAQDSLGNTVL 173
TRPV3 cd22194
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a ...
 180-304 1.16e-05

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a temperature-sensitive Transient Receptor Potential (TRP) ion channel that is activated by warm temperatures, synthetic small-molecule chemicals, and natural compounds from plants. TRPV3 function is regulated by physiological factors such as extracellular divalent cations and acidic pH, intracellular adenosine triphosphate, membrane voltage, and arachidonic acid. It is expressed in both neuronal and non-neuronal tissues including epidermal keratinocytes, epithelial cells in the gut, endothelial cells in blood vessels, and neurons in dorsal root ganglia and CNS. TRPV3 null mice have abnormal hair morphogenesis and compromised skin barrier function. It may play roles in inflammatory skin disorders, such as itch and pain sensation. TRPV3 is also expressed by many neuronal and non-neuronal tissues, showing that TRPV3 might play roles in other unknown cellular and physiological functions. TRPV3 belongs to the vanilloid TRP subfamily (TRPV), named after the founding member vanilloid receptor 1 (TRPV1). The structure of TRPV shows the typical topology features of all TRP ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.


Pssm-ID: 411978 [Multi-domain]  Cd Length: 680  Bit Score: 47.83  E-value: 1.16e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724784182 180 EVNMDGETALYQAADKGQERCVLALLEAGCDPNIltTAKCSALHPVSEK-----GDTSL-----------VQLLLEyKAH 243
Cdd:cd22194   136 EEAYEGQTALNIAIERRQGDIVKLLIAKGADVNA--HAKGVFFNPKYKHegfyfGETPLalaactnqpeiVQLLME-KES 212

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1724784182 244 TDFKNQHQEAP--LHLAV--------KNSHIPVIYSLLKAGCDN----NVTNKRSQTAMHLAAELGKIEVVEMLL 304
Cdd:cd22194   213 TDITSQDSRGNtvLHALVtvaedsktQNDFVKRMYDMILLKSENknleTIRNNEGLTPLQLAAKMGKAEILKYIL 287
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 3-90 1.48e-05

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 47.18  E-value: 1.48e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724784182   3 MLGRGLNANAKNVDNRTALHYAVAGKNKDAMQFLLQRRVKVDQKDKHGVAPIHLA-AWFGSLEILKSLVQAGAEQKVENE 81
Cdd:PHA02878  187 LLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLHISvGYCKDYDILKLLLEHGVDVNAKSY 266

                          90
                  ....*....|
gi 1724784182  82 -EGLNILHCA 90
Cdd:PHA02878  267 iLGLTALHSS 276
PHA02798 PHA02798
ankyrin-like protein; Provisional
 3-241 1.49e-05

ankyrin-like protein; Provisional


Pssm-ID: 222931 [Multi-domain]  Cd Length: 489  Bit Score: 47.52  E-value: 1.49e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724784182   3 MLGRGLNANAKNVDNRTALHYAVAGK---NKDAMQFLLQRRVKVDQKDKHGVAPIHLAAWFG---SLEILKSLVQAGAE- 75
Cdd:PHA02798   95 LIENGADINKKNSDGETPLYCLLSNGyinNLEILLFMIENGADTTLLDKDGFTMLQVYLQSNhhiDIEIIKLLLEKGVDi 174

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724784182  76 QKVENEEGLNILHCAAINNHT----EIVEYIV-NDLQMKELDKEDRSGnrpfalaaehgcaemldmLMEpYEMATMKPNK 150
Cdd:PHA02798  175 NTHNNKEKYDTLHCYFKYNIDridaDILKLFVdNGFIINKENKSHKKK------------------FME-YLNSLLYDNK 235

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724784182 151 RGDTPLhlaarndqleaVQLLLQSLDTrDEVNMDGETALYQAADKGQERCVLALLEAGCDPNILTTAKCSALHPVSEKGD 230
Cdd:PHA02798  236 RFKKNI-----------LDFIFSYIDI-NQVDELGFNPLYYSVSHNNRKIFEYLLQLGGDINIITELGNTCLFTAFENES 303

                         250
                  ....*....|.
gi 1724784182 231 TSLVQLLLEYK 241
Cdd:PHA02798  304 KFIFNSILNKK 314
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 270-350 2.81e-05

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 46.78  E-value: 2.81e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724784182 270 LLKAGCDNNVTNKRSQTAMHLAAELGKIEVVEMLLKAGLDLTLCDRQGKTALGVAARADEAIIVDMIikaerYYAWRTSN 349
Cdd:PLN03192  544 LLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHKIFRIL-----YHFASISD 618


                  .
gi 1724784182 350 P 350
Cdd:PLN03192  619 P 619
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 2-192 4.47e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 45.82  E-value: 4.47e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724784182   2 KMLGRGLNANAKNVDNRTALH-YAVAGKNKDAMQFLLQRRVKVDQKDKHGVAPIHLAAWFGSL-EILKSLVQAGAEQKVE 79
Cdd:PHA02876  292 KLLERGADVNAKNIKGETPLYlMAKNGYDTENIRTLIMLGADVNAADRLYITPLHQASTLDRNkDIVITLLELGANVNAR 371

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724784182  80 NEEGLNILHCAAINNHTEIVEYIVNDLQMKELDKEDRSGNRPFALAAEHGCAEMLDMLMEPYEMATmkPNKRGDTPLHLA 159
Cdd:PHA02876  372 DYCDKTPIHYAAVRNNVVIINTLLDYGADIEALSQKIGTALHFALCGTNPYMSVKTLIDRGANVNS--KNKDLSTPLHYA 449

                         170       180       190
                  ....*....|....*....|....*....|....
gi 1724784182 160 ARND-QLEAVQLLLQSLDTRDEVNMDGETALYQA 192
Cdd:PHA02876  450 CKKNcKLDVIEMLLDNGADVNAINIQNQYPLLIA 483
Ank_4 pfam13637
Ankyrin repeats (many copies);
286-326 6.79e-05

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 40.34  E-value: 6.79e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1724784182 286 TAMHLAAELGKIEVVEMLLKAGLDLTLCDRQGKTALGVAAR 326
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAAS 43
Ank_5 pfam13857
Ankyrin repeats (many copies);
247-291 1.22e-04

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 39.64  E-value: 1.22e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1724784182 247 KNQHQEAPLHLAVKNSHIPVIYSLLKAGCDNNVTNKRSQTAMHLA 291
Cdd:pfam13857  12 LDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
Ank_4 pfam13637
Ankyrin repeats (many copies);
152-205 1.29e-04

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 39.57  E-value: 1.29e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1724784182 152 GDTPLHLAARNDQLEAVQLLLQSLDTRDEVNMDGETALYQAADKGQERCVLALL 205
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 19-173 3.57e-04

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 43.15  E-value: 3.57e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724784182  19 TALHYAVAGKNKDAMQFLLQRRVKVDQKDK--------------HGVAPIHLAAWFGSLEILKSLVQAGAEQKVENEEGL 84
Cdd:TIGR00870 130 TALHLAAHRQNYEIVKLLLERGASVPARACgdffvksqgvdsfyHGESPLNAAACLGSPSIVALLSEDPADILTADSLGN 209

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724784182  85 NILHCAAINNHTEiVEYIVNDLQMKEldkedrsgnrpFALaaehgcaEMLDMLMEPYEMATMkPNKRGDTPLHLAARNDQ 164
Cdd:TIGR00870 210 TLLHLLVMENEFK-AEYEELSCQMYN-----------FAL-------SLLDKLRDSKELEVI-LNHQGLTPLKLAAKEGR 269


                  ....*....
gi 1724784182 165 LEAVQLLLQ 173
Cdd:TIGR00870 270 IVLFRLKLA 278
Ank_4 pfam13637
Ankyrin repeats (many copies);
187-238 4.23e-04

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 38.02  E-value: 4.23e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1724784182 187 TALYQAADKGQERCVLALLEAGCDPNILTTAKCSALHPVSEKGDTSLVQLLL 238
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
Ank_4 pfam13637
Ankyrin repeats (many copies);
118-172 5.91e-04

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 37.64  E-value: 5.91e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1724784182 118 GNRPFALAAEHGCAEMLDMLMEPYEMATMKpNKRGDTPLHLAARNDQLEAVQLLL 172
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAV-DGNGETALHFAASNGNVEVLKLLL 54
TRPV cd21882
Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily ...
 18-157 8.38e-04

Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily (TRPV), named after the vanilloid receptor 1 (TRPV1), consists of six members: four thermo-sensing channels (TRPV1, TRPV2, TRPV3, and TRPV4) and two Ca2+ selective channels (TRPV5 and TRPV6). The calcium-selective channels TRPV5 and TRPV6 can be heterotetramers and are important for general Ca2+ homeostasis. All four channels within the TRPV1-4 group show temperature-invoked currents when expressed in heterologous cell systems, ranging from activation at ~25C for TRPV4 to ~52C for TRPV2. The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains. The TRP family consists of membrane proteins that function as ion channels that communicate between the cell and its environment, by a vast array of physical or chemical stimuli, including radiation (in the form of temperature, infrared ,or light) and pressure (osmotic or mechanical). TRP channels are formed by a tetrameric complex of channel subunits. Based on sequence identity, the mammalian TRP channel family is classified into six subfamilies, with significant sequence similarity within the transmembrane domains, but very low similarity in their N- and C-terminal cytoplasmic regions. The six subfamilies are named based on their first member: TRPC (canonical), TRPV (vanilloid), TRPM (melastatin), TRPA (ankyrin), TRPML (mucolipin), and TRPP (polycystic).


Pssm-ID: 411975 [Multi-domain]  Cd Length: 600  Bit Score: 41.79  E-value: 8.38e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724784182  18 RTALHYAVAGKNKDAMQFLLQRRVKVD--------QKDKH-----GVAPIHLAAWFGSLEILKSLVQAGAE---QKVENE 81
Cdd:cd21882    74 QTALHIAIENRNLNLVRLLVENGADVSaratgrffRKSPGnlfyfGELPLSLAACTNQEEIVRLLLENGAQpaaLEAQDS 153

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724784182  82 EGLNILHCA-------------AINNHTEIVEYIVNDLQMKELDK-EDRSGNRPFALAAEHGCAEMLDMLMEPYEMATMK 147
Cdd:cd21882   154 LGNTVLHALvlqadntpensafVCQMYNLLLSYGAHLDPTQQLEEiPNHQGLTPLKLAAVEGKIVMFQHILQREFSGPYQ 233

                         170
                  ....*....|....*
gi 1724784182 148 PNKRGDT-----PLH 157
Cdd:cd21882   234 PLSRKFTewtygPVT 248
Ank_5 pfam13857
Ankyrin repeats (many copies);
110-159 8.76e-04

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 37.33  E-value: 8.76e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1724784182 110 ELDKEDRSGNRPFALAAEHGCAEMLDMLMEPYEMATMKpNKRGDTPLHLA 159
Cdd:pfam13857   8 DLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLK-DEEGLTALDLA 56
TRPV cd21882
Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily ...
 79-305 1.30e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily (TRPV), named after the vanilloid receptor 1 (TRPV1), consists of six members: four thermo-sensing channels (TRPV1, TRPV2, TRPV3, and TRPV4) and two Ca2+ selective channels (TRPV5 and TRPV6). The calcium-selective channels TRPV5 and TRPV6 can be heterotetramers and are important for general Ca2+ homeostasis. All four channels within the TRPV1-4 group show temperature-invoked currents when expressed in heterologous cell systems, ranging from activation at ~25C for TRPV4 to ~52C for TRPV2. The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains. The TRP family consists of membrane proteins that function as ion channels that communicate between the cell and its environment, by a vast array of physical or chemical stimuli, including radiation (in the form of temperature, infrared ,or light) and pressure (osmotic or mechanical). TRP channels are formed by a tetrameric complex of channel subunits. Based on sequence identity, the mammalian TRP channel family is classified into six subfamilies, with significant sequence similarity within the transmembrane domains, but very low similarity in their N- and C-terminal cytoplasmic regions. The six subfamilies are named based on their first member: TRPC (canonical), TRPV (vanilloid), TRPM (melastatin), TRPA (ankyrin), TRPML (mucolipin), and TRPP (polycystic).


Pssm-ID: 411975 [Multi-domain]  Cd Length: 600  Bit Score: 41.40  E-value: 1.30e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724784182  79 ENEEGLNILHCAAINNHTEiveyiVNDLQMKELDKEDRSGN-RPFALAAehgcaemldMLMEPYEmatmkpnkrGDTPLH 157
Cdd:cd21882    22 RGATGKTCLHKAALNLNDG-----VNEAIMLLLEAAPDSGNpKELVNAP---------CTDEFYQ---------GQTALH 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724784182 158 LAARNDQLEAVQLLLQS-LDTRDEVNMD------------GETALYQAADKGQERCVLALLEAGCDPNILTTAKC---SA 221
Cdd:cd21882    79 IAIENRNLNLVRLLVENgADVSARATGRffrkspgnlfyfGELPLSLAACTNQEEIVRLLLENGAQPAALEAQDSlgnTV 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724784182 222 LHPVSEKGD---------TSLVQLLLEYKAHTDFKNQHQEaplhlavknshipviysllkagcdnnVTNKRSQTAMHLAA 292
Cdd:cd21882   159 LHALVLQADntpensafvCQMYNLLLSYGAHLDPTQQLEE--------------------------IPNHQGLTPLKLAA 212

                         250
                  ....*....|...
gi 1724784182 293 ELGKIEVVEMLLK 305
Cdd:cd21882   213 VEGKIVMFQHILQ 225
PHA02791 PHA02791
ankyrin-like protein; Provisional
 250-348 1.39e-03

ankyrin-like protein; Provisional


Pssm-ID: 165154 [Multi-domain]  Cd Length: 284  Bit Score: 40.41  E-value: 1.39e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724784182 250 HQEAPLHLAVKNSHIPVIYSLLKAGCDNNVTnkRSQTAMHLAAELGKIEVVEMLLKAGLDLTLCDRQGKTALGVAARADE 329
Cdd:PHA02791   29 HGHSALYYAIADNNVRLVCTLLNAGALKNLL--ENEFPLHQAATLEDTKIVKILLFSGMDDSQFDDKGNTALYYAVDSGN 106

                          90       100
                  ....*....|....*....|....*
gi 1724784182 330 AIIVDMIIKAE---RYY---AWRTS 348
Cdd:PHA02791  107 MQTVKLFVKKNwrlMFYgktGWKTS 131
PHA02859 PHA02859
ankyrin repeat protein; Provisional
 11-139 1.46e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165195 [Multi-domain]  Cd Length: 209  Bit Score: 39.80  E-value: 1.46e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724784182  11 NAKNVDNRTALHYAVAGK--NKDAMQFLLQRRVKVDQKDKH-GVAPIHLAAWFG---SLEILKSLVQAGAEQKVENEEGL 84
Cdd:PHA02859   45 NDCNDLYETPIFSCLEKDkvNVEILKFLIENGADVNFKTRDnNLSALHHYLSFNknvEPEILKILIDSGSSITEEDEDGK 124

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1724784182  85 NILH--CAAINNHTEIVEYIVnDLQMKELDKEDRSGNRPFALAAEHGCAEMLDMLME 139
Cdd:PHA02859  125 NLLHmyMCNFNVRINVIKLLI-DSGVSFLNKDFDNNNILYSYILFHSDKKIFDFLTS 180
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 157-240 1.54e-03

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 41.04  E-value: 1.54e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724784182 157 HLAARNDQLeAVQLLLQSLDTRDEVNMDGETALYQAADKGQERCVLALLEAGCDPNILTTAKCSALHPVSEKGDTSLVQL 236
Cdd:PTZ00322   88 QLAASGDAV-GARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQL 166


                  ....
gi 1724784182 237 LLEY 240
Cdd:PTZ00322  167 LSRH 170
PHA02946 PHA02946
ankyin-like protein; Provisional
 168-339 1.87e-03

ankyin-like protein; Provisional


Pssm-ID: 165256 [Multi-domain]  Cd Length: 446  Bit Score: 40.42  E-value: 1.87e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724784182 168 VQLLLQSLDTRDEVNMDGETALYQAADKGQERCVLALLEAGCDPNILTTAKCSALHPVSEKGDTSL--VQLLLEYKAHTD 245
Cdd:PHA02946   55 VEELLHRGYSPNETDDDGNYPLHIASKINNNRIVAMLLTHGADPNACDKQHKTPLYYLSGTDDEVIerINLLVQYGAKIN 134

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724784182 246 FKNQHQEAPLHLAVKNSHIPVIYSLLKAGCDNNVTNK--RSQTAMHLAAELGKIEVVEMLLKAGLDLTLCDRQGKTALGV 323
Cdd:PHA02946  135 NSVDEEGCGPLLACTDPSERVFKKIMSIGFEARIVDKfgKNHIHRHLMSDNPKASTISWMMKLGISPSKPDHDGNTPLHI 214

                         170
                  ....*....|....*...
gi 1724784182 324 --AARADEAIIVDMIIKA 339
Cdd:PHA02946  215 vcSKTVKNVDIINLLLPS 232
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 57-210 2.07e-03

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 40.62  E-value: 2.07e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724784182  57 AAWFGSLEILKSLVQAGAEQKVENEEGLNILHCAAINNHTEIVEYIVNdlQMKELDKEDRSGNRPF--ALAAEHgcAEML 134
Cdd:PLN03192  532 VASTGNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLK--HACNVHIRDANGNTALwnAISAKH--HKIF 607

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1724784182 135 DMLmepYEMATMK-PNKRGDTpLHLAARNDQLEAV-QLLLQSLDTrDEVNMDGETALYQAADKGQERCVLALLEAGCD 210
Cdd:PLN03192  608 RIL---YHFASISdPHAAGDL-LCTAAKRNDLTAMkELLKQGLNV-DSEDHQGATALQVAMAEDHVDMVRLLIMNGAD 680
Ank_5 pfam13857
Ankyrin repeats (many copies);
6-57 2.26e-03

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 36.17  E-value: 2.26e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1724784182   6 RGLNANAKNVDNRTALHYAVAGKNKDAMQFLLQRRVKVDQKDKHGVAPIHLA 57
Cdd:pfam13857   5 GPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
Ank_4 pfam13637
Ankyrin repeats (many copies);
83-137 7.23e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 34.56  E-value: 7.23e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1724784182  83 GLNILHCAAINNHTEIVEYIVNDLqmKELDKEDRSGNRPFALAAEHGCAEMLDML 137
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKG--ADINAVDGNGETALHFAASNGNVEVLKLL 53
Ank_4 pfam13637
Ankyrin repeats (many copies);
4-37 8.38e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 34.56  E-value: 8.38e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1724784182   4 LGRGLNANAKNVDNRTALHYAVAGKNKDAMQFLL 37
Cdd:pfam13637  21 LEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 151-174 9.76e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 33.72  E-value: 9.76e-03
                           10        20
                   ....*....|....*....|....
gi 1724784182  151 RGDTPLHLAARNDQLEAVQLLLQS 174
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDK 24
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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