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Conserved domains on  [gi|1741408701|ref|XP_030626169|]
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tereporin-Ca1-like [Chanos chanos]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Anemone_cytotox super family cl05718
Sea anemone cytotoxic protein; Sea anemones are a rich source of cytotoxic proteins. ...
 72-177 1.04e-12

Sea anemone cytotoxic protein; Sea anemones are a rich source of cytotoxic proteins. Cytolysins comprise a group of more than 30 highly basic proteins with molecular masses of about 20 kDa. Cytolysins isolated from the sea anemone, Heteractis magnifica, include magnificalysin I (HMg I), magnificalysin II (HMg II) and Heteractis magnifica toxin (HMgtxn). These are highly homologous at their N-terminals. HMg I and II have molecular masses of approximately 19 kDa, and pI values of 9.4 and 10.0, respectively. Cytolysins isolated from other sea anemones Actinia tenebrosa (Tenebrosin-C, TN-C), Actinia equina (Equinatoxin, EqT) and Stichodactyla helianthus (ShC) exhibit pore-forming, haemolytic, cytotoxic, and heart stimulatory activities.


The actual alignment was detected with superfamily member pfam06369:

Pssm-ID: 399397  Cd Length: 176  Bit Score: 62.99  E-value: 1.04e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741408701  72 GGTACGAVGVLTYdlfikeKRRSDKMMAIMFSVPFDYTYYENWLAVGIFDRAQPCDHALYNLMYYESDSrfIRAratdPS 151
Cdd:pfam06369  78 GPVATGAVGVLAY------KMSSGNTLAVMFSVPFDYNWYSNWWNVKIYDGKRRADQKMYEELYYNNNP--IRG----DN 145

                          90       100
                  ....*....|....*....|....*....
gi 1741408701 152 IVYTWG---SVEIRASMSNAKSAIVQVEI 177
Cdd:pfam06369 146 GWEKRNlgyGLKLRGFMTSNGDAKLVIHI 174
 
Name Accession Description Interval E-value
Anemone_cytotox pfam06369
Sea anemone cytotoxic protein; Sea anemones are a rich source of cytotoxic proteins. ...
 72-177 1.04e-12

Sea anemone cytotoxic protein; Sea anemones are a rich source of cytotoxic proteins. Cytolysins comprise a group of more than 30 highly basic proteins with molecular masses of about 20 kDa. Cytolysins isolated from the sea anemone, Heteractis magnifica, include magnificalysin I (HMg I), magnificalysin II (HMg II) and Heteractis magnifica toxin (HMgtxn). These are highly homologous at their N-terminals. HMg I and II have molecular masses of approximately 19 kDa, and pI values of 9.4 and 10.0, respectively. Cytolysins isolated from other sea anemones Actinia tenebrosa (Tenebrosin-C, TN-C), Actinia equina (Equinatoxin, EqT) and Stichodactyla helianthus (ShC) exhibit pore-forming, haemolytic, cytotoxic, and heart stimulatory activities.


Pssm-ID: 399397  Cd Length: 176  Bit Score: 62.99  E-value: 1.04e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741408701  72 GGTACGAVGVLTYdlfikeKRRSDKMMAIMFSVPFDYTYYENWLAVGIFDRAQPCDHALYNLMYYESDSrfIRAratdPS 151
Cdd:pfam06369  78 GPVATGAVGVLAY------KMSSGNTLAVMFSVPFDYNWYSNWWNVKIYDGKRRADQKMYEELYYNNNP--IRG----DN 145

                          90       100
                  ....*....|....*....|....*....
gi 1741408701 152 IVYTWG---SVEIRASMSNAKSAIVQVEI 177
Cdd:pfam06369 146 GWEKRNlgyGLKLRGFMTSNGDAKLVIHI 174
 
Name Accession Description Interval E-value
Anemone_cytotox pfam06369
Sea anemone cytotoxic protein; Sea anemones are a rich source of cytotoxic proteins. ...
 72-177 1.04e-12

Sea anemone cytotoxic protein; Sea anemones are a rich source of cytotoxic proteins. Cytolysins comprise a group of more than 30 highly basic proteins with molecular masses of about 20 kDa. Cytolysins isolated from the sea anemone, Heteractis magnifica, include magnificalysin I (HMg I), magnificalysin II (HMg II) and Heteractis magnifica toxin (HMgtxn). These are highly homologous at their N-terminals. HMg I and II have molecular masses of approximately 19 kDa, and pI values of 9.4 and 10.0, respectively. Cytolysins isolated from other sea anemones Actinia tenebrosa (Tenebrosin-C, TN-C), Actinia equina (Equinatoxin, EqT) and Stichodactyla helianthus (ShC) exhibit pore-forming, haemolytic, cytotoxic, and heart stimulatory activities.


Pssm-ID: 399397  Cd Length: 176  Bit Score: 62.99  E-value: 1.04e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741408701  72 GGTACGAVGVLTYdlfikeKRRSDKMMAIMFSVPFDYTYYENWLAVGIFDRAQPCDHALYNLMYYESDSrfIRAratdPS 151
Cdd:pfam06369  78 GPVATGAVGVLAY------KMSSGNTLAVMFSVPFDYNWYSNWWNVKIYDGKRRADQKMYEELYYNNNP--IRG----DN 145

                          90       100
                  ....*....|....*....|....*....
gi 1741408701 152 IVYTWG---SVEIRASMSNAKSAIVQVEI 177
Cdd:pfam06369 146 GWEKRNlgyGLKLRGFMTSNGDAKLVIHI 174
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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