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Conserved domains on  [gi|1776058889|ref|XP_031456674|]
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LOW QUALITY PROTEIN: thrombopoietin receptor [Phasianus colchicus]

Protein Classification

EpoR_lig-bind and FN3 domain-containing protein( domain architecture ID 10557304)

EpoR_lig-bind and FN3 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
EpoR_lig-bind pfam09067
Erythropoietin receptor, ligand binding; Members of this family interact with erythropoietin ...
 33-133 2.80e-43

Erythropoietin receptor, ligand binding; Members of this family interact with erythropoietin (EPO), with subsequent initiation of the downstream chain of events associated with binding of EPO to the receptor, including EPO-induced erythroblast proliferation and differentiation through induction of the JAK2/STAT5 signaling cascade. The domain adopts a secondary structure composed of a short amino-terminal helix, followed by two beta-sandwich regions.


:

Pssm-ID: 401127  Cd Length: 104  Bit Score: 150.65  E-value: 2.80e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776058889  33 SQDAMLLAEVPEDILCFSRSFEDLTCFWDEEEASG---THRFYYWYSRDAPTMCAVSTQRRGASGMRHICVFPSQDVRLF 109
Cdd:pfam09067   1 SQAALLLPEKPEDIKCFSREKEDFTCFWEEEEDGGlptTYSFSYAYENETVKECPLYSTSGANSTRLFICFFPKNDVSLF 80

                          90       100
                  ....*....|....*....|....
gi 1776058889 110 TQLHVLVLDAATNRTRHRRELSVD 133
Cdd:pfam09067  81 VPLHITVVATNTNGTRYSRELSVE 104
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 374-465 1.15e-10

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 58.28  E-value: 1.15e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776058889 374 EAPRHVQATA-TQGRLSLQWLPPLEALAEQLEYQVRYGTDNSPDWKVLQVPRAARKEVL--DLRPGARYRAQVRAqpggp 450
Cdd:cd00063     2 SPPTNLRVTDvTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVTPGSETSYTltGLKPGTEYEFRVRA----- 76

                          90
                  ....*....|....*
gi 1776058889 451 QYRGSWSAWSQPVVV 465
Cdd:cd00063    77 VNGGGESPPSESVTV 91
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 140-265 3.82e-06

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 45.57  E-value: 3.82e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776058889 140 PPVNISAHWAGATgQLRVSWQPPLADYPNFFLYEVCYHPMTPTvtprgtapgdlpahPTNRAHPPTARgaaasqgtrqgl 219
Cdd:cd00063     3 PPTNLRVTDVTST-SVTLSWTPPEDDGGPITGYVVEYREKGSG--------------DWKEVEVTPGS------------ 55

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1776058889 220 vqaDTWVVLRELQPGLRYHIQVRSKPDGTsmdgvWGPWSEVVVAET 265
Cdd:cd00063    56 ---ETSYTLTGLKPGTEYEFRVRAVNGGG-----ESPPSESVTVTT 93
 
Name Accession Description Interval E-value
EpoR_lig-bind pfam09067
Erythropoietin receptor, ligand binding; Members of this family interact with erythropoietin ...
 33-133 2.80e-43

Erythropoietin receptor, ligand binding; Members of this family interact with erythropoietin (EPO), with subsequent initiation of the downstream chain of events associated with binding of EPO to the receptor, including EPO-induced erythroblast proliferation and differentiation through induction of the JAK2/STAT5 signaling cascade. The domain adopts a secondary structure composed of a short amino-terminal helix, followed by two beta-sandwich regions.


Pssm-ID: 401127  Cd Length: 104  Bit Score: 150.65  E-value: 2.80e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776058889  33 SQDAMLLAEVPEDILCFSRSFEDLTCFWDEEEASG---THRFYYWYSRDAPTMCAVSTQRRGASGMRHICVFPSQDVRLF 109
Cdd:pfam09067   1 SQAALLLPEKPEDIKCFSREKEDFTCFWEEEEDGGlptTYSFSYAYENETVKECPLYSTSGANSTRLFICFFPKNDVSLF 80

                          90       100
                  ....*....|....*....|....
gi 1776058889 110 TQLHVLVLDAATNRTRHRRELSVD 133
Cdd:pfam09067  81 VPLHITVVATNTNGTRYSRELSVE 104
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 374-465 1.15e-10

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 58.28  E-value: 1.15e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776058889 374 EAPRHVQATA-TQGRLSLQWLPPLEALAEQLEYQVRYGTDNSPDWKVLQVPRAARKEVL--DLRPGARYRAQVRAqpggp 450
Cdd:cd00063     2 SPPTNLRVTDvTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVTPGSETSYTltGLKPGTEYEFRVRA----- 76

                          90
                  ....*....|....*
gi 1776058889 451 QYRGSWSAWSQPVVV 465
Cdd:cd00063    77 VNGGGESPPSESVTV 91
fn3 pfam00041
Fibronectin type III domain;
375-457 2.02e-09

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 54.73  E-value: 2.02e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776058889 375 APRHVQATATQGR-LSLQWLPPLEALAEQLEYQVRYGTDNSPD-WKVLQVPRAARK-EVLDLRPGARYRAQVRAQPGGpq 451
Cdd:pfam00041   2 APSNLTVTDVTSTsLTVSWTPPPDGNGPITGYEVEYRPKNSGEpWNEITVPGTTTSvTLTGLKPGTEYEVRVQAVNGG-- 79


                  ....*.
gi 1776058889 452 YRGSWS 457
Cdd:pfam00041  80 GEGPPS 85
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 140-265 3.82e-06

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 45.57  E-value: 3.82e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776058889 140 PPVNISAHWAGATgQLRVSWQPPLADYPNFFLYEVCYHPMTPTvtprgtapgdlpahPTNRAHPPTARgaaasqgtrqgl 219
Cdd:cd00063     3 PPTNLRVTDVTST-SVTLSWTPPEDDGGPITGYVVEYREKGSG--------------DWKEVEVTPGS------------ 55

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1776058889 220 vqaDTWVVLRELQPGLRYHIQVRSKPDGTsmdgvWGPWSEVVVAET 265
Cdd:cd00063    56 ---ETSYTLTGLKPGTEYEFRVRAVNGGG-----ESPPSESVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 375-445 3.40e-05

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 42.60  E-value: 3.40e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1776058889  375 APRHVQATA-TQGRLSLQWLPPLEA--LAEQLEYQVRYGTDNSPDWKVLQVPRAARKEVLDLRPGARYRAQVRA 445
Cdd:smart00060   3 PPSNLRVTDvTSTSVTLSWEPPPDDgiTGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRA 76
 
Name Accession Description Interval E-value
EpoR_lig-bind pfam09067
Erythropoietin receptor, ligand binding; Members of this family interact with erythropoietin ...
 33-133 2.80e-43

Erythropoietin receptor, ligand binding; Members of this family interact with erythropoietin (EPO), with subsequent initiation of the downstream chain of events associated with binding of EPO to the receptor, including EPO-induced erythroblast proliferation and differentiation through induction of the JAK2/STAT5 signaling cascade. The domain adopts a secondary structure composed of a short amino-terminal helix, followed by two beta-sandwich regions.


Pssm-ID: 401127  Cd Length: 104  Bit Score: 150.65  E-value: 2.80e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776058889  33 SQDAMLLAEVPEDILCFSRSFEDLTCFWDEEEASG---THRFYYWYSRDAPTMCAVSTQRRGASGMRHICVFPSQDVRLF 109
Cdd:pfam09067   1 SQAALLLPEKPEDIKCFSREKEDFTCFWEEEEDGGlptTYSFSYAYENETVKECPLYSTSGANSTRLFICFFPKNDVSLF 80

                          90       100
                  ....*....|....*....|....
gi 1776058889 110 TQLHVLVLDAATNRTRHRRELSVD 133
Cdd:pfam09067  81 VPLHITVVATNTNGTRYSRELSVE 104
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 374-465 1.15e-10

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 58.28  E-value: 1.15e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776058889 374 EAPRHVQATA-TQGRLSLQWLPPLEALAEQLEYQVRYGTDNSPDWKVLQVPRAARKEVL--DLRPGARYRAQVRAqpggp 450
Cdd:cd00063     2 SPPTNLRVTDvTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVTPGSETSYTltGLKPGTEYEFRVRA----- 76

                          90
                  ....*....|....*
gi 1776058889 451 QYRGSWSAWSQPVVV 465
Cdd:cd00063    77 VNGGGESPPSESVTV 91
fn3 pfam00041
Fibronectin type III domain;
375-457 2.02e-09

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 54.73  E-value: 2.02e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776058889 375 APRHVQATATQGR-LSLQWLPPLEALAEQLEYQVRYGTDNSPD-WKVLQVPRAARK-EVLDLRPGARYRAQVRAQPGGpq 451
Cdd:pfam00041   2 APSNLTVTDVTSTsLTVSWTPPPDGNGPITGYEVEYRPKNSGEpWNEITVPGTTTSvTLTGLKPGTEYEVRVQAVNGG-- 79


                  ....*.
gi 1776058889 452 YRGSWS 457
Cdd:pfam00041  80 GEGPPS 85
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 140-265 3.82e-06

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 45.57  E-value: 3.82e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776058889 140 PPVNISAHWAGATgQLRVSWQPPLADYPNFFLYEVCYHPMTPTvtprgtapgdlpahPTNRAHPPTARgaaasqgtrqgl 219
Cdd:cd00063     3 PPTNLRVTDVTST-SVTLSWTPPEDDGGPITGYVVEYREKGSG--------------DWKEVEVTPGS------------ 55

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1776058889 220 vqaDTWVVLRELQPGLRYHIQVRSKPDGTsmdgvWGPWSEVVVAET 265
Cdd:cd00063    56 ---ETSYTLTGLKPGTEYEFRVRAVNGGG-----ESPPSESVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 375-445 3.40e-05

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 42.60  E-value: 3.40e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1776058889  375 APRHVQATA-TQGRLSLQWLPPLEA--LAEQLEYQVRYGTDNSPDWKVLQVPRAARKEVLDLRPGARYRAQVRA 445
Cdd:smart00060   3 PPSNLRVTDvTSTSVTLSWEPPPDDgiTGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRA 76
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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