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Conserved domains on  [gi|1785405974|ref|XP_031747713|]
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rho GTPase-activating protein 30 [Xenopus tropicalis]

Protein Classification

Rho GTPase-activating protein( domain architecture ID 10138166)

Rho GTPase-activating protein for Rho/Rac/Cdc42-like small GTPases that act as molecular switches, active in their GTP-bound form but inactive when bound to GDP

CATH:  1.10.555.10
Gene Ontology:  GO:0007165|GO:0005096
PubMed:  17222083|12480336
SCOP:  4001255

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RhoGAP_CdGAP cd04384
RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 19-213 6.27e-104

RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP is recruited to focal adhesions via the interaction with the scaffold protein actopaxin (alpha-parvin). Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


:

Pssm-ID: 239849 [Multi-domain]  Cd Length: 195  Bit Score: 328.69  E-value: 6.27e-104
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785405974   19 KTFGCDLLEHLSISGLEVPQVLRSCTDFVEEHGVVDGIYRLCGIASNVHKLRQEFDMERQPDLSKDTYLQDVHCVSSLCK 98
Cdd:cd04384      1 RVFGCDLTEHLLNSGQDVPQVLKSCTEFIEKHGIVDGIYRLSGIASNIQRLRHEFDSEQIPDLTKDVYIQDIHSVSSLCK 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785405974   99 AYFRELPNPLLTYQLYDKFADAVAIQLEEQRLIKIKEVLKELPLPHYRTLEYLMRHLLRMASFSSQTNMHARNLAIVWAP 178
Cdd:cd04384     81 LYFRELPNPLLTYQLYEKFSEAVSAASDEERLEKIHDVIQQLPPPHYRTLEFLMRHLSRLAKYCSITNMHAKNLAIVWAP 160

                          170       180       190
                   ....*....|....*....|....*....|....*
gi 1785405974  179 NLLRSKDIESSGFNGTAAFMEVRIQSIVVEFILTH 213
Cdd:cd04384    161 NLLRSKQIESACFSGTAAFMEVRIQSVVVEFILNH 195
 
Name Accession Description Interval E-value
RhoGAP_CdGAP cd04384
RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 19-213 6.27e-104

RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP is recruited to focal adhesions via the interaction with the scaffold protein actopaxin (alpha-parvin). Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239849 [Multi-domain]  Cd Length: 195  Bit Score: 328.69  E-value: 6.27e-104
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785405974   19 KTFGCDLLEHLSISGLEVPQVLRSCTDFVEEHGVVDGIYRLCGIASNVHKLRQEFDMERQPDLSKDTYLQDVHCVSSLCK 98
Cdd:cd04384      1 RVFGCDLTEHLLNSGQDVPQVLKSCTEFIEKHGIVDGIYRLSGIASNIQRLRHEFDSEQIPDLTKDVYIQDIHSVSSLCK 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785405974   99 AYFRELPNPLLTYQLYDKFADAVAIQLEEQRLIKIKEVLKELPLPHYRTLEYLMRHLLRMASFSSQTNMHARNLAIVWAP 178
Cdd:cd04384     81 LYFRELPNPLLTYQLYEKFSEAVSAASDEERLEKIHDVIQQLPPPHYRTLEFLMRHLSRLAKYCSITNMHAKNLAIVWAP 160

                          170       180       190
                   ....*....|....*....|....*....|....*
gi 1785405974  179 NLLRSKDIESSGFNGTAAFMEVRIQSIVVEFILTH 213
Cdd:cd04384    161 NLLRSKQIESACFSGTAAFMEVRIQSVVVEFILNH 195
RhoGAP smart00324
GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac ...
 35-214 1.76e-53

GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases. etter domain limits and outliers.


Pssm-ID: 214618  Cd Length: 174  Bit Score: 184.78  E-value: 1.76e-53
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785405974    35 EVPQVLRSCTDFVEEHGV-VDGIYRLCGIASNVHKLRQEFDmeRQPDLSKDTYLQDVHCVSSLCKAYFRELPNPLLTYQL 113
Cdd:smart00324    2 PIPIIVEKCIEYLEKRGLdTEGIYRVSGSKSRVKELRDAFD--SGPDPDLDLSEYDVHDVAGLLKLFLRELPEPLITYEL 79

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785405974   114 YDKFADAVAIQLEEQRLIKIKEVLKELPLPHYRTLEYLMRHLLRMASFSSQTNMHARNLAIVWAPNLLRSKDIESsgfng 193
Cdd:smart00324   80 YEEFIEAAKLEDETERLRALRELLSLLPPANRATLRYLLAHLNRVAEHSEENKMTARNLAIVFGPTLLRPPDGEV----- 154

                           170       180
                    ....*....|....*....|.
gi 1785405974   194 tAAFMEVRIQSIVVEFILTHV 214
Cdd:smart00324  155 -ASLKDIRHQNTVIEFLIENA 174
RhoGAP pfam00620
RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.
 37-185 2.58e-53

RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.


Pssm-ID: 459875  Cd Length: 148  Bit Score: 183.13  E-value: 2.58e-53
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785405974   37 PQVLRSCTDFVEEHGV-VDGIYRLCGIASNVHKLRQEFDmeRQPDLSKDTYLQDVHCVSSLCKAYFRELPNPLLTYQLYD 115
Cdd:pfam00620    1 PLIVRKCVEYLEKRGLdTEGIFRVSGSASRIKELREAFD--RGPDVDLDLEEEDVHVVASLLKLFLRELPEPLLTFELYE 78

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785405974  116 KFADAVAIQLEEQRLIKIKEVLKELPLPHYRTLEYLMRHLLRMASFSSQTNMHARNLAIVWAPNLLRSKD 185
Cdd:pfam00620   79 EFIEAAKLPDEEERLEALRELLRKLPPANRDTLRYLLAHLNRVAQNSDVNKMNAHNLAIVFGPTLLRPPD 148
 
Name Accession Description Interval E-value
RhoGAP_CdGAP cd04384
RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 19-213 6.27e-104

RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP is recruited to focal adhesions via the interaction with the scaffold protein actopaxin (alpha-parvin). Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239849 [Multi-domain]  Cd Length: 195  Bit Score: 328.69  E-value: 6.27e-104
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785405974   19 KTFGCDLLEHLSISGLEVPQVLRSCTDFVEEHGVVDGIYRLCGIASNVHKLRQEFDMERQPDLSKDTYLQDVHCVSSLCK 98
Cdd:cd04384      1 RVFGCDLTEHLLNSGQDVPQVLKSCTEFIEKHGIVDGIYRLSGIASNIQRLRHEFDSEQIPDLTKDVYIQDIHSVSSLCK 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785405974   99 AYFRELPNPLLTYQLYDKFADAVAIQLEEQRLIKIKEVLKELPLPHYRTLEYLMRHLLRMASFSSQTNMHARNLAIVWAP 178
Cdd:cd04384     81 LYFRELPNPLLTYQLYEKFSEAVSAASDEERLEKIHDVIQQLPPPHYRTLEFLMRHLSRLAKYCSITNMHAKNLAIVWAP 160

                          170       180       190
                   ....*....|....*....|....*....|....*
gi 1785405974  179 NLLRSKDIESSGFNGTAAFMEVRIQSIVVEFILTH 213
Cdd:cd04384    161 NLLRSKQIESACFSGTAAFMEVRIQSVVVEFILNH 195
RhoGAP smart00324
GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac ...
 35-214 1.76e-53

GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases. etter domain limits and outliers.


Pssm-ID: 214618  Cd Length: 174  Bit Score: 184.78  E-value: 1.76e-53
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785405974    35 EVPQVLRSCTDFVEEHGV-VDGIYRLCGIASNVHKLRQEFDmeRQPDLSKDTYLQDVHCVSSLCKAYFRELPNPLLTYQL 113
Cdd:smart00324    2 PIPIIVEKCIEYLEKRGLdTEGIYRVSGSKSRVKELRDAFD--SGPDPDLDLSEYDVHDVAGLLKLFLRELPEPLITYEL 79

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785405974   114 YDKFADAVAIQLEEQRLIKIKEVLKELPLPHYRTLEYLMRHLLRMASFSSQTNMHARNLAIVWAPNLLRSKDIESsgfng 193
Cdd:smart00324   80 YEEFIEAAKLEDETERLRALRELLSLLPPANRATLRYLLAHLNRVAEHSEENKMTARNLAIVFGPTLLRPPDGEV----- 154

                           170       180
                    ....*....|....*....|.
gi 1785405974   194 tAAFMEVRIQSIVVEFILTHV 214
Cdd:smart00324  155 -ASLKDIRHQNTVIEFLIENA 174
RhoGAP pfam00620
RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.
 37-185 2.58e-53

RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.


Pssm-ID: 459875  Cd Length: 148  Bit Score: 183.13  E-value: 2.58e-53
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785405974   37 PQVLRSCTDFVEEHGV-VDGIYRLCGIASNVHKLRQEFDmeRQPDLSKDTYLQDVHCVSSLCKAYFRELPNPLLTYQLYD 115
Cdd:pfam00620    1 PLIVRKCVEYLEKRGLdTEGIFRVSGSASRIKELREAFD--RGPDVDLDLEEEDVHVVASLLKLFLRELPEPLLTFELYE 78

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785405974  116 KFADAVAIQLEEQRLIKIKEVLKELPLPHYRTLEYLMRHLLRMASFSSQTNMHARNLAIVWAPNLLRSKD 185
Cdd:pfam00620   79 EFIEAAKLPDEEERLEALRELLRKLPPANRDTLRYLLAHLNRVAQNSDVNKMNAHNLAIVFGPTLLRPPD 148
RhoGAP cd00159
RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like ...
 37-213 2.45e-52

RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to GDP. The Rho family of small G proteins, which includes Cdc42Hs, activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. G proteins generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude. The RhoGAPs are one of the major classes of regulators of Rho G proteins.


Pssm-ID: 238090 [Multi-domain]  Cd Length: 169  Bit Score: 181.35  E-value: 2.45e-52
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785405974   37 PQVLRSCTDFVEEHGV-VDGIYRLCGIASNVHKLRQEFDMERQPDLSKDTylqDVHCVSSLCKAYFRELPNPLLTYQLYD 115
Cdd:cd00159      1 PLIIEKCIEYLEKNGLnTEGIFRVSGSASKIEELKKKFDRGEDIDDLEDY---DVHDVASLLKLYLRELPEPLIPFELYD 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785405974  116 KFADAVAIQLEEQRLIKIKEVLKELPLPHYRTLEYLMRHLLRMASFSSQTNMHARNLAIVWAPNLLRSKDIESSgfngta 195
Cdd:cd00159     78 EFIELAKIEDEEERIEALKELLKSLPPENRDLLKYLLKLLHKISQNSEVNKMTASNLAIVFAPTLLRPPDSDDE------ 151

                          170
                   ....*....|....*...
gi 1785405974  196 AFMEVRIQSIVVEFILTH 213
Cdd:cd00159    152 LLEDIKKLNEIVEFLIEN 169
RhoGAP_fRGD1 cd04398
RhoGAP_fRGD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 21-218 3.11e-41

RhoGAP_fRGD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal RGD1-like proteins. Yeast Rgd1 is a GAP protein for Rho3 and Rho4 and plays a role in low-pH response. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239863  Cd Length: 192  Bit Score: 150.63  E-value: 3.11e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785405974   21 FGCDLLEHLSISGLEVPQVLRSCTDFVEEHGV-VDGIYRLCGIASNVHKLRQEFDME--RQPDLSKDTYLQDVHCVSSLC 97
Cdd:cd04398      1 FGVPLEDLILREGDNVPNIVYQCIQAIENFGLnLEGIYRLSGNVSRVNKLKELFDKDplNVLLISPEDYESDIHSVASLL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785405974   98 KAYFRELPNPLLTYQLYDKFADAVAIQLEEQRLIKIKEVLKELPLPHYRTLEYLMRHLLRMASFSSQTNMHARNLAIVWA 177
Cdd:cd04398     81 KLFFRELPEPLLTKALSREFIEAAKIEDESRRRDALHGLINDLPDANYATLRALMFHLARIKEHESVNRMSVNNLAIIWG 160

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|...
gi 1785405974  178 PNLLR--SKDIESSGFngtaafmevriQSIVVEFILTHVEQLF 218
Cdd:cd04398    161 PTLMNaaPDNAADMSF-----------QSRVIETLLDNAYQIF 192
RhoGAP_ARHGAP27_15_12_9 cd04403
RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ...
 21-212 1.16e-39

RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are studied show GAP activity towards Rac1, some additionally show activity towards Cdc42. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239868 [Multi-domain]  Cd Length: 187  Bit Score: 145.61  E-value: 1.16e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785405974   21 FGCDLLEHLSISGLEVPQVLRSCTDFVEEHGV-VDGIYRLCGIASNVHKLRQEFDMERQPDLSkDTYLQDVHCVSSLCKA 99
Cdd:cd04403      1 FGCHLEALCQRENSTVPKFVRLCIEAVEKRGLdVDGIYRVSGNLAVIQKLRFAVDHDEKLDLD-DSKWEDIHVITGALKL 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785405974  100 YFRELPNPLLTYQLYDKFADAVAIQLEEQRLIKIKEVLKELPLPHYRTLEYLMRHLLRMASFSSQTNMHARNLAIVWAPN 179
Cdd:cd04403     80 FFRELPEPLFPYSLFNDFVAAIKLSDYEQRVSAVKDLIKSLPKPNHDTLKMLFRHLCRVIEHGEKNRMTTQNLAIVFGPT 159

                          170       180       190
                   ....*....|....*....|....*....|...
gi 1785405974  180 LLRSKDIESSgfngTAAFMevRIQSIVVEFILT 212
Cdd:cd04403    160 LLRPEQETGN----IAVHM--VYQNQIVELILL 186
RhoGAP_nadrin cd04386
RhoGAP_nadrin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 21-218 1.42e-38

RhoGAP_nadrin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Nadrin-like proteins. Nadrin, also named Rich-1, has been shown to be involved in the regulation of Ca2+-dependent exocytosis in neurons and recently has been implicated in tight junction maintenance in mammalian epithelium. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239851  Cd Length: 203  Bit Score: 143.37  E-value: 1.42e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785405974   21 FGCDLLEHLSISGLEVPQVLRSCTDFVEEHGVVD-GIYRLCGIASNVHKLRQEFDMErQPDLSKDTYLQDVHCVSSLCKA 99
Cdd:cd04386      5 FGTPLEEHLKRTGREIALPIEACVMCLLETGMNEeGLFRVGGGASKLKRLKAALDAG-TFSLPLDEFYSDPHAVASALKS 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785405974  100 YFRELPNPLLTYQLYDKFADAVAIQLEEQRLIKIKEVLKELPLPHYRTLEYLMRHLLRMASFSSQTNMHARNLAIVWAPN 179
Cdd:cd04386     84 YLRELPDPLLTYNLYEDWVQAANKPDEDERLQAIWRILNKLPRENRDNLRYLIKFLSKLAQKSDENKMSPSNIAIVLAPN 163

                          170       180       190
                   ....*....|....*....|....*....|....*....
gi 1785405974  180 LLRSKdIESSGFNGTAAfMEVRIqSIVVEFILTHVEQLF 218
Cdd:cd04386    164 LLWAK-NEGSLAEMAAG-TSVHV-VAIVELIISHADWFF 199
RhoGAP_ARHGAP21 cd04395
RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 36-218 5.81e-36

RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction complex. It has been shown to function as a GAP of Cdc42 and RhoA, and to interact with alpha-catenin and Arf6. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239860  Cd Length: 196  Bit Score: 135.61  E-value: 5.81e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785405974   36 VPQVLRSCTDFVEEHGV-VDGIYRLCGIASNVHKLRQEFDMERQPDLSKDTYLQDVHCVSSLCKAYFRELPNPLLTYQLY 114
Cdd:cd04395     18 VPLIVEVCCNIVEARGLeTVGIYRVPGNNAAISALQEELNRGGFDIDLQDPRWRDVNVVSSLLKSFFRKLPEPLFTNELY 97

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785405974  115 DKFADAVAIQLEEQRLIKIKEVLKELPLPHYRTLEYLMRHLLRMASFSSQTNMHARNLAIVWAPNLLRSKDIessgfNGT 194
Cdd:cd04395     98 PDFIEANRIEDPVERLKELRRLIHSLPDHHYETLKHLIRHLKTVADNSEVNKMEPRNLAIVFGPTLVRTSDD-----NME 172

                          170       180
                   ....*....|....*....|....
gi 1785405974  195 AAFMEVRIQSIVVEFILTHVEQLF 218
Cdd:cd04395    173 TMVTHMPDQCKIVETLIQHYDWFF 196
RhoGAP_chimaerin cd04372
RhoGAP_chimaerin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 21-218 7.50e-36

RhoGAP_chimaerin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms that each contain a C-terminal GAP domain, and a central C1 domain which binds phorbol esters, inducing a conformational change that activates the protein; one splice form is lacking the N-terminal Src homology-2 (SH2) domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239837 [Multi-domain]  Cd Length: 194  Bit Score: 134.95  E-value: 7.50e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785405974   21 FGCDLLEHLSISGLEVPQVLRSCTDFVEEHGVV-DGIYRLCGIASNVHKLRQEFDME-RQPDLSKDTYlQDVHCVSSLCK 98
Cdd:cd04372      1 YGCDLTTLVKAHNTQRPMVVDMCIREIEARGLQsEGLYRVSGFAEEIEDVKMAFDRDgEKADISATVY-PDINVITGALK 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785405974   99 AYFRELPNPLLTYQLYDKFADAVAIQLEEQRLIKIKEVLKELPLPHYRTLEYLMRHLLRMASFSSQTNMHARNLAIVWAP 178
Cdd:cd04372     80 LYFRDLPIPVITYDTYPKFIDAAKISNPDERLEAVHEALMLLPPAHYETLRYLMEHLKRVTLHEKDNKMNAENLGIVFGP 159

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|
gi 1785405974  179 NLLRSKDIESSgfngtAAFMEVRIQSIVVEFILTHVEQLF 218
Cdd:cd04372    160 TLMRPPEDSAL-----TTLNDMRYQILIVQLLITNEDVLF 194
RhoGAP_ARAP cd04385
RhoGAP_ARAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present ...
 24-188 1.26e-34

RhoGAP_ARAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ArfGAP activity is PIP3-dependent, ARAPs are considered integration points for phosphoinositide, Arf and Rho signaling. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239850  Cd Length: 184  Bit Score: 131.28  E-value: 1.26e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785405974   24 DLLEHLSISGLEVPQVLRSCTDFVEEHGV-VDGIYRLCGIASNVHKLRQEFDMER---QPDLSKDTylqdVHCVSSLCKA 99
Cdd:cd04385      3 PALEDQQLTDNDIPVIVDKCIDFITQHGLmSEGIYRKNGKNSSVKKLLEAFRKDArsvQLREGEYT----VHDVADVLKR 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785405974  100 YFRELPNPLLTYQLYDKFADAVAIQLEEQRLIKIKEVLKELPLPHYRTLEYLMRHLLRMASFSSQTNMHARNLAIVWAPN 179
Cdd:cd04385     79 FLRDLPDPLLTSELHAEWIEAAELENKDERIARYKELIRRLPPINRATLKVLIGHLYRVQKHSDENQMSVHNLALVFGPT 158


                   ....*....
gi 1785405974  180 LLRSKDIES 188
Cdd:cd04385    159 LFQTDEHSV 167
RhoGAP_GMIP_PARG1 cd04378
RhoGAP_GMIP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 21-213 4.59e-31

RhoGAP_GMIP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP (Gem interacting protein) and PARG1 (PTPL1-associated RhoGAP1). GMIP plays important roles in neurite growth and axonal guidance, and interacts with Gem, a member of the RGK subfamily of the Ras small GTPase superfamily, through the N-terminal half of the protein. GMIP contains a C-terminal RhoGAP domain. GMIP inhibits RhoA function, but is inactive towards Rac1 and Cdc41. PARG1 interacts with Rap2, also a member of the Ras small GTPase superfamily whose exact function is unknown, and shows strong preference for Rho. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239843  Cd Length: 203  Bit Score: 121.76  E-value: 4.59e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785405974   21 FGCDLLEHLSISGLEVPQVLRSCTDFVEEHGV-VDGIYRLCGIASNVHKLRQEFDMER-QPDLSKDTylqdVHCVSSLCK 98
Cdd:cd04378      1 FGVDFSQVPRDFPDEVPFIIKKCTSEIENRALgVQGIYRVSGSKARVEKLCQAFENGKdLVELSELS----PHDISSVLK 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785405974   99 AYFRELPNPLLTYQLYDKFadaVAIQLEEQR-----------------LIKIKEVLKELPLPHYRTLEYLMRHLLRMASF 161
Cdd:cd04378     77 LFLRQLPEPLILFRLYNDF---IALAKEIQRdteedkapntpievnriIRKLKDLLRQLPASNYNTLQHLIAHLYRVAEQ 153

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1785405974  162 SSQTNMHARNLAIVWAPNLLRSKDIESSgfNGTAAFMEVRIQSIVVEFILTH 213
Cdd:cd04378    154 FEENKMSPNNLGIVFGPTLIRPRPGDAD--VSLSSLVDYGYQARLVEFLITN 203
RhoGAP-p50rhoGAP cd04404
RhoGAP-p50rhoGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 36-218 4.62e-31

RhoGAP-p50rhoGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p50RhoGAP-like proteins; p50RhoGAP, also known as RhoGAP-1, contains a C-terminal RhoGAP domain and an N-terminal Sec14 domain which binds phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3). It is ubiquitously expressed and preferentially active on Cdc42. This subgroup also contains closely related ARHGAP8. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239869 [Multi-domain]  Cd Length: 195  Bit Score: 121.29  E-value: 4.62e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785405974   36 VPQVLRSCTDFVEEHGV-VDGIYRLCGIASNVHKLRQEFDMERQPDLSKdtyLQDVHCVSSLCKAYFRELPNPLLTYQLY 114
Cdd:cd04404     23 IPPVVRETVEYLQAHALtTEGIFRRSANTQVVKEVQQKYNMGEPVDFDQ---YEDVHLPAVILKTFLRELPEPLLTFDLY 99

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785405974  115 DKFADAVAIQlEEQRLIKIKEVLKELPLPHYRTLEYLMRHLLRMASFSSQTNMHARNLAIVWAPNLLRSKDIES--SGFN 192
Cdd:cd04404    100 DDIVGFLNVD-KEERVERVKQLLQTLPEENYQVLKYLIKFLVQVSAHSDQNKMTNSNLAVVFGPNLLWAKDASMslSAIN 178

                          170       180
                   ....*....|....*....|....*.
gi 1785405974  193 GTAAFmevriqsivVEFILTHVEQLF 218
Cdd:cd04404    179 PINTF---------TKFLLDHQDEIF 195
RhoGAP_fBEM3 cd04400
RhoGAP_fBEM3: RhoGAP (GTPase-activator [GAP] protein for Rho-like small GTPases) domain of ...
 21-180 4.78e-28

RhoGAP_fBEM3: RhoGAP (GTPase-activator [GAP] protein for Rho-like small GTPases) domain of fungal BEM3-like proteins. Bem3 is a GAP protein of Cdc42, and is specifically involved in the control of the initial assembly of the septin ring in yeast bud formation. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239865 [Multi-domain]  Cd Length: 190  Bit Score: 112.45  E-value: 4.78e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785405974   21 FGCDLLEHLSIS-----GLEVPQVLRSCTDFVEEHGVV--DGIYRLCGIASNVHKLRQEFDMERQPDLSKDTYLQDVHCV 93
Cdd:cd04400      2 FGSPLEEAVELSshkynGRDLPSVVYRCIEYLDKNRAIyeEGIFRLSGSASVIKQLKERFNTEYDVDLFSSSLYPDVHTV 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785405974   94 SSLCKAYFRELPNPLLTYQLYDKFADAVAIQLEE-QRLIKIKEVLKELPLPHYRTLEYLMRHLLRMASFSSQTNMHARNL 172
Cdd:cd04400     82 AGLLKLYLRELPTLILGGELHNDFKRLVEENHDRsQRALELKDLVSQLPQANYDLLYVLFSFLRKIIEHSDVNKMNLRNV 161


                   ....*...
gi 1785405974  173 AIVWAPNL 180
Cdd:cd04400    162 CIVFSPTL 169
RhoGAP_myosin_IX cd04377
RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 36-185 5.20e-28

RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in class IX myosins. Class IX myosins contain a characteristic head domain, a neck domain, a tail domain which contains a C6H2-zinc binding motif and a RhoGAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239842  Cd Length: 186  Bit Score: 112.15  E-value: 5.20e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785405974   36 VPQVLRSCTDFVEEHGV-VDGIYRLCGIASNVHKLRQEfdMERQPDLSKdtyLQD--VHCVSSLCKAYFRELPNPLLTYQ 112
Cdd:cd04377     15 VPLVLEKLLEHIEMHGLyTEGIYRKSGSANKIKELRQG--LDTDPDSVN---LEDypIHVITSVLKQWLRELPEPLMTFE 89

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1785405974  113 LYDKFADAVAIQLEEQRLIKIKEVLKELPLPHYRTLEYLMRHLLRMASFSSQTNMHARNLAIVWAPNLLRSKD 185
Cdd:cd04377     90 LYENFLRAMELEEKQERVRALYSVLEQLPRANLNTLERLIFHLVRVALQEEVNRMSANALAIVFAPCILRCPD 162
RhoGAP_ARHGAP22_24_25 cd04390
RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ...
 36-218 6.68e-28

RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for Rac1 and Cdc42. Short isoforms (without the PH domain) of ARHGAP24, called RC-GAP72 and p73RhoGAP, and of ARHGAP22, called p68RacGAP, has been shown to be involved in angiogenesis and endothelial cell capillary formation. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239855 [Multi-domain]  Cd Length: 199  Bit Score: 112.54  E-value: 6.68e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785405974   36 VPQVLRSCTDFVEEHGVVD-GIYRLCGIASNVHKLRQEFDMERQPDLSKDTylqDVHCVSSLCKAYFRELPNPLLTYQLY 114
Cdd:cd04390     22 VPILVEQCVDFIREHGLKEeGLFRLPGQANLVKQLQDAFDAGERPSFDSDT---DVHTVASLLKLYLRELPEPVIPWAQY 98

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785405974  115 DKFADAVAIQL--EEQRLIKIKEVLKELPLPHYRTLEYLMRHLLRMASFSSQTNMHARNLAIVWAPNLLRSKdIESSgfn 192
Cdd:cd04390     99 EDFLSCAQLLSkdEEKGLGELMKQVSILPKVNYNLLSYICRFLDEVQSNSSVNKMSVQNLATVFGPNILRPK-VEDP--- 174

                          170       180
                   ....*....|....*....|....*...
gi 1785405974  193 gtAAFME--VRIQSIVVEFILTHvEQLF 218
Cdd:cd04390    175 --ATIMEgtPQIQQLMTVMISKH-EPLF 199
RhoGAP_Graf cd04374
RhoGAP_Graf: GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase ...
 38-213 1.14e-27

RhoGAP_Graf: GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences cytoskeletal changes mediated by Rho proteins. Graf exhibits GAP activity toward RhoA and Cdc42, but only weakly activates Rac1. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239839  Cd Length: 203  Bit Score: 111.72  E-value: 1.14e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785405974   38 QVLRSCTDFVEEHGVVD-GIYRLCGIASNVHKLRQEFdMERQP----DLSKDTYLQDVHCVSSLCKAYFRELPNPLLTYQ 112
Cdd:cd04374     30 KFVRKCIEAVETRGINEqGLYRVVGVNSKVQKLLSLG-LDPKTstpgDVDLDNSEWEIKTITSALKTYLRNLPEPLMTYE 108

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785405974  113 LYDKFADAVAIQLEEQRLIKIKEVLKELPLPHYRTLEYLMRHLLRMASFSSQTNMHARNLAIVWAPNLLRSKDiESsgfn 192
Cdd:cd04374    109 LHNDFINAAKSENLESRVNAIHSLVHKLPEKNREMLELLIKHLTNVSDHSKKNLMTVSNLGVVFGPTLLRPQE-ET---- 183

                          170       180
                   ....*....|....*....|.
gi 1785405974  193 gTAAFMEVRIQSIVVEFILTH 213
Cdd:cd04374    184 -VAAIMDIKFQNIVVEILIEN 203
RhoGAP_Bcr cd04387
RhoGAP_Bcr: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Bcr ...
 36-213 1.04e-25

RhoGAP_Bcr: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Bcr (breakpoint cluster region protein)-like proteins. Bcr is a multidomain protein with a variety of enzymatic functions. It contains a RhoGAP and a Rho GEF domain, a Ser/Thr kinase domain, an N-terminal oligomerization domain, and a C-terminal PDZ binding domain, in addition to PH and C2 domains. Bcr is a negative regulator of: i) RacGTPase, via the Rho GAP domain, ii) the Ras-Raf-MEK-ERK pathway, via phosphorylation of the Ras binding protein AF-6, and iii) the Wnt signaling pathway through binding beta-catenin. Bcr can form a complex with beta-catenin and Tcf1. The Wnt signaling pathway is involved in cell proliferation, differentiation, and cell renewal. Bcr was discovered as a fusion partner of Abl. The Bcr-Abl fusion is characteristic for a large majority of chronic myelogenous leukemias (CML). Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239852 [Multi-domain]  Cd Length: 196  Bit Score: 106.17  E-value: 1.04e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785405974   36 VPQVLRSCTDFVEEHGVVD-GIYRLCGIASNVHKLRQEFDMERQPDLSKDTYLqDVHCVSSLCKAYFRELPNPLLTYQLY 114
Cdd:cd04387     16 VPYIVRQCVEEVERRGMEEvGIYRISGVATDIQALKAAFDTNNKDVSVMLSEM-DVNAIAGTLKLYFRELPEPLFTDELY 94

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785405974  115 DKFADAVAIQLEEQRLIKIKEVLKELPLPHYRTLEYLMRHLLRMASFSSQTNMHARNLAIVWAPNLLRSKDIESSGFNGT 194
Cdd:cd04387     95 PNFAEGIALSDPVAKESCMLNLLLSLPDPNLVTFLFLLHHLKRVAEREEVNKMSLHNLATVFGPTLLRPSEKESKIPTNT 174

                          170       180
                   ....*....|....*....|..
gi 1785405974  195 AAF---MEVRIQSIVVEFILTH 213
Cdd:cd04387    175 MTDswsLEVMSQVQVLLYFLQL 196
RhoGAP_p190 cd04373
RhoGAP_p190: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 35-210 1.23e-25

RhoGAP_p190: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p190-like proteins. p190, also named RhoGAP5, plays a role in neuritogenesis and axon branch stability. p190 shows a preference for Rho, over Rac and Cdc42, and consists of an N-terminal GTPase domain and a C-terminal GAP domain. The central portion of p190 contains important regulatory phosphorylation sites. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239838  Cd Length: 185  Bit Score: 105.23  E-value: 1.23e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785405974   35 EVPQVLRSCTDFVEEHGV-VDGIYRLCGIASNVHKLRQEFDMERQPDL-SKDTylqDVHCVSSLCKAYFRELPNPLLTYQ 112
Cdd:cd04373     14 PIPIFLEKCVEFIEATGLeTEGIYRVSGNKTHLDSLQKQFDQDHNLDLvSKDF---TVNAVAGALKSFFSELPDPLIPYS 90

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785405974  113 LYDKFADAVAIQLEEQRLIKIKEVLKELPLPHYRTLEYLMRHLLRMASFSSQTNMHARNLAIVWAPNLLRSkDIESSG-F 191
Cdd:cd04373     91 MHLELVEAAKINDREQRLHALKELLKKFPPENFDVFKYVITHLNKVSQNSKVNLMTSENLSICFWPTLMRP-DFTSMEaL 169

                          170
                   ....*....|....*....
gi 1785405974  192 NGTAAFmevriQSIVVEFI 210
Cdd:cd04373    170 SATRIY-----QTIIETFI 183
RhoGAP_ARHGAP6 cd04376
RhoGAP_ARHGAP6: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 34-218 3.92e-25

RhoGAP_ARHGAP6: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP6-like proteins. ArhGAP6 shows GAP activity towards RhoA, but not towards Cdc42 and Rac1. ArhGAP6 is often deleted in microphthalmia with linear skin defects syndrome (MLS); MLS is a severe X-linked developmental disorder. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239841  Cd Length: 206  Bit Score: 104.83  E-value: 3.92e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785405974   34 LEVPQVLRSCTDFVEEHGV-VDGIYRLCGIASNVHKLRQEFDMERQPDLSKDtylQDVHCVSSLCKAYFRELPNPLLTYQ 112
Cdd:cd04376      7 RQVPRLVESCCQHLEKHGLqTVGIFRVGSSKKRVRQLREEFDRGIDVVLDEN---HSVHDVAALLKEFFRDMPDPLLPRE 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785405974  113 LYDKFADAVAIQLEEQrLIKIKEVLKELPLPHYRTLEYLMRHLLRMASFSSQT-----------NMHARNLAIVWAPNLL 181
Cdd:cd04376     84 LYTAFIGTALLEPDEQ-LEALQLLIYLLPPCNCDTLHRLLKFLHTVAEHAADSidedgqevsgnKMTSLNLATIFGPNLL 162

                          170       180       190
                   ....*....|....*....|....*....|....*...
gi 1785405974  182 RSKDIESSGFNGTAAFMEVRIQSI-VVEFILTHVEQLF 218
Cdd:cd04376    163 HKQKSGEREFVQASLRIEESTAIInVVQTMIDNYEELF 200
RhoGap_RalBP1 cd04381
RhoGap_RalBP1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 33-221 4.15e-25

RhoGap_RalBP1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in RalBP1 proteins, also known as RLIP, RLIP76 or cytocentrin. RalBP1 plays an important role in endocytosis during interphase. During mitosis, RalBP1 transiently associates with the centromere and has been shown to play an essential role in the proper assembly of the mitotic apparatus. RalBP1 is an effector of the Ral GTPase which itself is an effector of Ras. RalBP1 contains a RhoGAP domain, which shows weak activity towards Rac1 and Cdc42, but not towards Ral, and a Ral effector domain binding motif. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239846 [Multi-domain]  Cd Length: 182  Bit Score: 103.67  E-value: 4.15e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785405974   33 GLEVPQVLRSCTDFVEEHGV-VDGIYRLCGIASNVHKLRQEFDMERQPDLSKdtylQDVHCVSSLCKAYFRELPNPLLTY 111
Cdd:cd04381     17 GIDLPLVFRECIDYVEKHGMkCEGIYKVSGIKSKVDELKAAYNRRESPNLEE----YEPPTVASLLKQYLRELPEPLLTK 92

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785405974  112 QLYDKFADAVAIQLEEQRLIKIKEVLKELPLPHYRTLEYLMRHLLRMASFSSQTNMHARNLAIVWAPNllrskdiessgf 191
Cdd:cd04381     93 ELMPRFEEACGRPTEAEREQELQRLLKELPECNRLLLAWLIVHMDHVIAQELETKMNIQNISIVLSPT------------ 160

                          170       180       190
                   ....*....|....*....|....*....|
gi 1785405974  192 ngtaafmeVRIQSIVVEFILTHVEQLFGDM 221
Cdd:cd04381    161 --------VQISNRLLYALLTHCQELFGNV 182
RhoGAP_PARG1 cd04409
RhoGAP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 21-213 2.30e-24

RhoGAP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of PARG1 (PTPL1-associated RhoGAP1). PARG1 was originally cloned as an interaction partner of PTPL1, an intracellular protein-tyrosine phosphatase. PARG1 interacts with Rap2, also a member of the Ras small GTPase superfamily whose exact function is unknown, and shows strong preference for Rho. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239874  Cd Length: 211  Bit Score: 102.58  E-value: 2.30e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785405974   21 FGCDLLEHLSISGLEVPQVLRSCTDFVEEHGV-VDGIYRLCGIASNVHKLRQEFdmERQPDLSKDTYLQDvHCVSSLCKA 99
Cdd:cd04409      1 FGADFAQVAKKSPDGIPFIIKKCTSEIESRALcLKGIYRVNGAKSRVEKLCQAF--ENGKDLVELSELSP-HDISNVLKL 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785405974  100 YFRELPNPLLTYQLYDKFAD-AVAIQL--EEQR-------------------LIKIKEVLKELPLPHYRTLEYLMRHLLR 157
Cdd:cd04409     78 YLRQLPEPLILFRLYNEFIGlAKESQHvnETQEakknsdkkwpnmctelnriLLKSKDLLRQLPAPNYNTLQFLIVHLHR 157

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1785405974  158 MASFSSQTNMHARNLAIVWAPNLLRSKDIESSgfNGTAAFMEVRIQSIVVEFILTH 213
Cdd:cd04409    158 VSEQAEENKMSASNLGIIFGPTLIRPRPTDAT--VSLSSLVDYPHQARLVELLITY 211
RhoGAP_GMIP cd04408
RhoGAP_GMIP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP ...
 21-213 4.68e-24

RhoGAP_GMIP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP (Gem interacting protein). GMIP plays important roles in neurite growth and axonal guidance, and interacts with Gem, a member of the RGK subfamily of the Ras small GTPase superfamily, through the N-terminal half of the protein. GMIP contains a C-terminal RhoGAP domain. GMIP inhibits RhoA function, but is inactive towards Rac1 and Cdc41. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239873  Cd Length: 200  Bit Score: 101.43  E-value: 4.68e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785405974   21 FGCDLLEHLSISGLEVPQVLRSCTDFVEEHGV-VDGIYRLCGIASNVHKLRQEFDMER-QPDLSKDTylqdVHCVSSLCK 98
Cdd:cd04408      1 FGVDFSQLPRDFPEEVPFVVVRCTAEIENRALgVQGIYRISGSKARVEKLCQAFENGRdLVDLSGHS----PHDITSVLK 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785405974   99 AYFRELPNPLLTYQLYDKFadaVAIQLEEQRLI---------------KIKEVLKELPLPHYRTLEYLMRHLLRMASFSS 163
Cdd:cd04408     77 HFLKELPEPVLPFQLYDDF---IALAKELQRDSekaaespsiveniirSLKELLGRLPVSNYNTLRHLMAHLYRVAERFE 153

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|
gi 1785405974  164 QTNMHARNLAIVWAPNLLRSKDiesSGFNGTAAFMEVRIQSIVVEFILTH 213
Cdd:cd04408    154 DNKMSPNNLGIVFGPTLLRPLV---GGDVSMICLLDTGYQAQLVEFLISN 200
RhoGAP_FAM13A1a cd04393
RhoGAP_FAM13A1a: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 19-180 1.79e-23

RhoGAP_FAM13A1a: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of FAM13A1, isoform a-like proteins. The function of FAM13A1a is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by up several orders of magnitude.


Pssm-ID: 239858 [Multi-domain]  Cd Length: 189  Bit Score: 99.46  E-value: 1.79e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785405974   19 KTFGCDL--LEHLSISGLEVPQVLRSCTDFVEEHGVV-DGIYRLCGIASNVHKLRQEFDMERQPDLSKDTylqDVHCVSS 95
Cdd:cd04393      1 KVFGVPLqeLQQAGQPENGVPAVVRHIVEYLEQHGLEqEGLFRVNGNAETVEWLRQRLDSGEEVDLSKEA---DVCSAAS 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785405974   96 LCKAYFRELPNPLLTYQLYDKFadavaIQL------EEQRLIKIKEVLKELPLPHYRTLEYLMRHLLRMASFSSQTNMHA 169
Cdd:cd04393     78 LLRLFLQELPEGLIPASLQIRL-----MQLyqdyngEDEFGRKLRDLLQQLPPVNYSLLKFLCHFLSNVASQHHENRMTA 152

                          170
                   ....*....|.
gi 1785405974  170 RNLAIVWAPNL 180
Cdd:cd04393    153 ENLAAVFGPDV 163
RhoGAP_myosin_IXB cd04407
RhoGAP_myosin_IXB: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 36-185 2.21e-23

RhoGAP_myosin_IXB: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in myosins IXB. Class IX myosins contain a characteristic head domain, a neck domain and a tail domain which contains a C6H2-zinc binding motif and a Rho-GAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239872 [Multi-domain]  Cd Length: 186  Bit Score: 98.91  E-value: 2.21e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785405974   36 VPQVLRSCTDFVEEHGV-VDGIYRLCGIASNVHKLRQEfdMERQPDLSKdtyLQD--VHCVSSLCKAYFRELPNPLLTYQ 112
Cdd:cd04407     15 VPIVLEKLLEHVEMHGLyTEGIYRKSGSANRMKELHQL--LQADPENVK---LENypIHAITGLLKQWLRELPEPLMTFA 89

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1785405974  113 LYDKFADAVAIQLEEQRLIKIKEVLKELPLPHYRTLEYLMRHLLRMASFSSQTNMHARNLAIVWAPNLLRSKD 185
Cdd:cd04407     90 QYNDFLRAVELPEKQEQLQAIYRVLEQLPTANHNTLERLIFHLVKVALEEDVNRMSPNALAIVFAPCLLRCPD 162
RhoGAP_ARHGAP20 cd04402
RhoGAP_ARHGAP20: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 36-220 1.18e-22

RhoGAP_ARHGAP20: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP20-like proteins. ArhGAP20, also known as KIAA1391 and RA-RhoGAP, contains a RhoGAP, a RA, and a PH domain, and ANXL repeats. ArhGAP20 is activated by Rap1 and induces inactivation of Rho, which in turn leads to neurite outgrowth. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239867  Cd Length: 192  Bit Score: 96.98  E-value: 1.18e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785405974   36 VPQVLRSCTDFVEEHG-VVDGIYRLCGIASNVHKLRQEFDMERQPDLSKdtylQDVHCVSSLCKAYFRELPNPLLTYQLY 114
Cdd:cd04402     15 LPKPILDMLSLLYQKGpSTEGIFRRSANAKACKELKEKLNSGVEVDLKA----EPVLLLASVLKDFLRNIPGSLLSSDLY 90

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785405974  115 DKFADAVAIQLEEQRLIKIKEVLKELPLPHYRTLEYLMRhLLRMASFSSQTN-MHARNLAIVWAPNLLRSKDiessgfnG 193
Cdd:cd04402     91 EEWMSALDQENEEEKIAELQRLLDKLPRPNVLLLKHLIC-VLHNISQNSETNkMDAFNLAVCIAPSLLWPPA-------S 162

                          170       180
                   ....*....|....*....|....*...
gi 1785405974  194 TAAFME-VRIQSIVVEFILTHVEQLFGD 220
Cdd:cd04402    163 SELQNEdLKKVTSLVQFLIENCQEIFGE 190
RhoGAP_myosin_IXA cd04406
RhoGAP_myosin_IXA: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 21-185 1.36e-21

RhoGAP_myosin_IXA: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in myosins IXA. Class IX myosins contain a characteristic head domain, a neck domain and a tail domain which contains a C6H2-zinc binding motif and a Rho-GAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239871  Cd Length: 186  Bit Score: 93.91  E-value: 1.36e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785405974   21 FGCDLlEHLSISGLEVPQVLRSCTDFVEEHGV-VDGIYRLCGIASNVHKLRQEFDMERQpDLSKDTYlqDVHCVSSLCKA 99
Cdd:cd04406      1 FGVEL-SRLTSEDRSVPLVVEKLINYIEMHGLyTEGIYRKSGSTNKIKELRQGLDTDAN-SVNLDDY--NIHVIASVFKQ 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785405974  100 YFRELPNPLLTYQLYDKFADAVAIQLEEQRLIKIKEVLKELPLPHYRTLEYLMRHLLRMaSFSSQTN-MHARNLAIVWAP 178
Cdd:cd04406     77 WLRDLPNPLMTFELYEEFLRAMGLQERRETVRGVYSVIDQLSRTHLNTLERLIFHLVRI-ALQEETNrMSANALAIVFAP 155


                   ....*..
gi 1785405974  179 NLLRSKD 185
Cdd:cd04406    156 CILRCPD 162
RhoGAP_SYD1 cd04379
RhoGAP_SYD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present ...
 21-199 2.71e-21

RhoGAP_SYD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in SYD-1_like proteins. Syd-1, first identified and best studied in C.elegans, has been shown to play an important role in neuronal development by specifying axonal properties. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239844  Cd Length: 207  Bit Score: 93.69  E-value: 2.71e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785405974   21 FGCDL--LEHLSISGLEVPQVLRSCTDFVEEHGV-VDGIYRLCGIASNVHKLRQEFdmERQP---DLSKDTYlQDVHCVS 94
Cdd:cd04379      1 FGVPLsrLVEREGESRDVPIVLQKCVQEIERRGLdVIGLYRLCGSAAKKKELRDAF--ERNSaavELSEELY-PDINVIT 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785405974   95 SLCKAYFRELPNPLLTYQLYDKFADAVAIQLEEQRLIKIKEVLKELP-LPHYR--TLEYLMRHLLRMASFSSQTNMHARN 171
Cdd:cd04379     78 GVLKDYLRELPEPLITPQLYEMVLEALAVALPNDVQTNTHLTLSIIDcLPLSAkaTLLLLLDHLSLVLSNSERNKMTPQN 157

                          170       180
                   ....*....|....*....|....*...
gi 1785405974  172 LAIVWAPNLLRSKDIESSGFNGTAAFME 199
Cdd:cd04379    158 LAVCFGPVLMFCSQEFSRYGISPTSKMA 185
RhoGAP_srGAP cd04383
RhoGAP_srGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 19-211 4.81e-21

RhoGAP_srGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in srGAPs. srGAPs are components of the intracellular part of Slit-Robo signalling pathway that is important for axon guidance and cell migration. srGAPs contain an N-terminal FCH domain, a central RhoGAP domain and a C-terminal SH3 domain; this SH3 domain interacts with the intracellular proline-rich-tail of the Roundabout receptor (Robo). This interaction with Robo then activates the rhoGAP domain which in turn inhibits Cdc42 activity. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239848  Cd Length: 188  Bit Score: 92.48  E-value: 4.81e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785405974   19 KTFGCDLLEHLSISGLEVPQVLRSCTDFVEEHGVV-DGIYRLCGIASNVHKLRQEFdmERQPD-LSKDTYLQDVHCVSSL 96
Cdd:cd04383      1 KLFNGSLEEYIQDSGQAIPLVVESCIRFINLYGLQhQGIFRVSGSQVEVNDIKNAF--ERGEDpLADDQNDHDINSVAGV 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785405974   97 CKAYFRELPNPLLTYQLYDKFADAVAIQLEEQRLIKIKEVLKELPLPHYRTLEYLMRHLLRMASFSSQTNMHARNLAIVW 176
Cdd:cd04383     79 LKLYFRGLENPLFPKERFEDLMSCVKLENPTERVHQIREILSTLPRSVIIVMRYLFAFLNHLSQFSDENMMDPYNLAICF 158

                          170       180       190
                   ....*....|....*....|....*....|....*
gi 1785405974  177 APNLLRSKDiessgfNGTAAFMEVRIQSIVVEFIL 211
Cdd:cd04383    159 GPTLMPVPE------GQDQVSCQAHVNELIKTIII 187
RhoGAP_fLRG1 cd04397
RhoGAP_fLRG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 21-217 2.42e-19

RhoGAP_fLRG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal LRG1-like proteins. Yeast Lrg1p is required for efficient cell fusion, and mother-daughter cell separation, possibly through acting as a RhoGAP specifically regulating 1,3-beta-glucan synthesis. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239862  Cd Length: 213  Bit Score: 88.19  E-value: 2.42e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785405974   21 FGCDLLEHLSISGLEVPQVLRSCTDFVEEHGV-VDGIYRLCGiasNVHKLRQEFDM-----ERQPDLSKDTYLQdvhcVS 94
Cdd:cd04397     12 FGADSTLGVGPGKLRIPALIDDIISAMRQMDMsVEGVFRKNG---NIRRLKELTEEidknpTEVPDLSKENPVQ----LA 84

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785405974   95 SLCKAYFRELPNPLLTYQLYDKFADAVAIQLEEQRLIKIKEVLKELPLPHYRTLEYLMRHLLRMASFS-----SQTNMHA 169
Cdd:cd04397     85 ALLKKFLRELPDPLLTFKLYRLWISSQKIEDEEERKRVLHLVYCLLPKYHRDTMEVLFSFLKWVSSFShideeTGSKMDI 164

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*...
gi 1785405974  170 RNLAIVWAPNLLRSKDIESSGFNGTaaFMEVRiqsiVVEFILTHVEQL 217
Cdd:cd04397    165 HNLATVITPNILYSKTDNPNTGDEY--FLAIE----AVNYLIENNEEF 206
RhoGAP_MgcRacGAP cd04382
RhoGAP_MgcRacGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 36-211 3.71e-19

RhoGAP_MgcRacGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in MgcRacGAP proteins. MgcRacGAP plays an important dual role in cytokinesis: i) it is part of centralspindlin-complex, together with the mitotic kinesin MKLP1, which is critical for the structure of the central spindle by promoting microtuble bundling. ii) after phosphorylation by aurora B MgcRacGAP becomes an effective regulator of RhoA and plays an important role in the assembly of the contractile ring and the initiation of cytokinesis. MgcRacGAP-like proteins contain a N-terminal C1-like domain, and a C-terminal RhoGAP domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239847  Cd Length: 193  Bit Score: 86.96  E-value: 3.71e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785405974   36 VPQVLRSCTDFVEEHGVVD-GIYRLCGIASNVHKLRQEFDMERQ-PDLSKdtylQDVHCVSSLCKAYFRELPNPLLTYQL 113
Cdd:cd04382     17 IPALIVHCVNEIEARGLTEeGLYRVSGSEREVKALKEKFLRGKTvPNLSK----VDIHVICGCLKDFLRSLKEPLITFAL 92

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785405974  114 YDKFADAVAIQLEEQRLIKIKEVLKELPLPHYRTLEYLMRHLLRMASfSSQTNMHARNLAIVWAPNLLRSKDIESSgfnG 193
Cdd:cd04382     93 WKEFMEAAEILDEDNSRAALYQAISELPQPNRDTLAFLILHLQRVAQ-SPECKMDINNLARVFGPTIVGYSVPNPD---P 168

                          170
                   ....*....|....*...
gi 1785405974  194 TAAFMEVRIQSIVVEFIL 211
Cdd:cd04382    169 MTILQDTVRQPRVVERLL 186
RhoGAP_ARHGAP18 cd04391
RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 33-218 4.22e-16

RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP18-like proteins. The function of ArhGAP18 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239856  Cd Length: 216  Bit Score: 78.93  E-value: 4.22e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785405974   33 GLEVPQVLRSCTDFVEEHGV-VDGIYRLCGIASNVHKLRQEFDMerqpDLSKDTYLQD---VHCVSSLCKAYFRELPNPL 108
Cdd:cd04391     19 GSKVPLIFQKLINKLEERGLeTEGILRIPGSAQRVKFLCQELEA----KFYEGTFLWDqvkQHDAASLLKLFIRELPQPL 94

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785405974  109 LTYQLYDKFADAVAIQLEEQRLIKIKEVLKELPLPHYRTLEYLMRHLLRMASFSSQTNMHARNLAIVWAPNLLRSKDIES 188
Cdd:cd04391     95 LTVEYLPAFYSVQGLPSKKDQLQALNLLVLLLPEANRDTLKALLEFLQKVVDHEEKNKMNLWNVAMIMAPNLFPPRGKHS 174

                          170       180       190
                   ....*....|....*....|....*....|.
gi 1785405974  189 SGFNGTAAFMEVRIQ-SIVVEFILTHVEQLF 218
Cdd:cd04391    175 KDNESLQEEVNMAAGcANIMRLLIRYQDLLW 205
RhoGAP_DLC1 cd04375
RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 19-180 2.71e-15

RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a START (StAR-related lipid transfer action) domain. DLC1 has tumor suppressor activity in cell culture. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239840  Cd Length: 220  Bit Score: 76.69  E-value: 2.71e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785405974   19 KTFGCDLLEHLSISGLEVPQVLRSCTDFVEEHGVVD-GIYRLCGIASNVHKLRQefdMERQPDLSKDTYLQDVHCVSSLC 97
Cdd:cd04375      3 NVFGVPLLVNLQRTGQPLPRSIQQAMRWLRNNALDQvGLFRKSGVKSRIQKLRS---MIESSTDNVNYDGQQAYDVADML 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785405974   98 KAYFRELPNPLLTYQLYDKFADAVAIQLEEQRLIKIKEVLKELPLPHYRTLEYLMRHLLRMASFSSQTNMHARNLAIVWA 177
Cdd:cd04375     80 KQYFRDLPEPLLTNKLSETFIAIFQYVPKEQRLEAVQCAILLLPDENREVLQTLLYFLSDVAANSQENQMTATNLAVCLA 159


                   ...
gi 1785405974  178 PNL 180
Cdd:cd04375    160 PSL 162
RhoGAP-ARHGAP11A cd04394
RhoGAP-ARHGAP11A: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 36-208 1.75e-14

RhoGAP-ARHGAP11A: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP11A-like proteins. The mouse homolog of human ArhGAP11A has been detected as a gene exclusively expressed in immature ganglion cells, potentially playing a role in retinal development. The exact function of ArhGAP11A is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239859 [Multi-domain]  Cd Length: 202  Bit Score: 73.66  E-value: 1.75e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785405974   36 VPQVLRSCTDFVEEHGVVDGIYRLCGIASNVHKLRQEFDmerqpdlSKDTYLQDVHC--VSSLCKAYFRELPNPLLTYQL 113
Cdd:cd04394     20 VPKFLVDACTFLLDHLSTEGLFRKSGSVVRQKELKAKLE-------GGEACLSSALPcdVAGLLKQFFRELPEPLLPYDL 92

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785405974  114 YDKFADAVAIQLEEQRLIKIKEVLKELPLPHYRTLEYLMRHLLRMASFSSQTNMHARNLAIVWAPNLLRSKDIESSGFNG 193
Cdd:cd04394     93 HEALLKAQELPTDEERKSATLLLTCLLPDEHVNTLRYFFSFLYDVAQRCSENKMDSSNLAVIFAPNLFQSEEGGEKMSSS 172

                          170
                   ....*....|....*
gi 1785405974  194 TAafMEVRIQSIVVE 208
Cdd:cd04394    173 TE--KRLRLQAAVVQ 185
RhoGAP_KIAA1688 cd04389
RhoGAP_KIAA1688: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ...
 21-182 2.15e-14

RhoGAP_KIAA1688: GTPase-activator protein (GAP) domain for Rho-like GTPases found in KIAA1688-like proteins; KIAA1688 is a protein of unknown function that contains a RhoGAP domain and a myosin tail homology 4 (MyTH4) domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239854  Cd Length: 187  Bit Score: 73.19  E-value: 2.15e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785405974   21 FGCDLLEHL-----SISGLEVPQVLRSCTDFVEEHGV--VDGIYRLCGIASNVHKLRQEFDMERQPDlskdTYLQDVHCV 93
Cdd:cd04389      1 FGSSLEEIMdrqkeKYPELKLPWILTFLSEKVLALGGfqTEGIFRVPGDIDEVNELKLRVDQWDYPL----SGLEDPHVP 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785405974   94 SSLCKAYFRELPNPLLTYQLYDKfadavAIQLEEQRlIKIKEVLKELPLPHYRTLEYLMrHLLRM---ASFSSQTNMHAR 170
Cdd:cd04389     77 ASLLKLWLRELEEPLIPDALYQQ-----CISASEDP-DKAVEIVQKLPIINRLVLCYLI-NFLQVfaqPENVAHTKMDVS 149

                          170
                   ....*....|..
gi 1785405974  171 NLAIVWAPNLLR 182
Cdd:cd04389    150 NLAMVFAPNILR 161
RhoGAP_fSAC7_BAG7 cd04396
RhoGAP_fSAC7_BAG7: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 36-213 1.17e-09

RhoGAP_fSAC7_BAG7: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal SAC7 and BAG7-like proteins. Both proteins are GTPase activating proteins of Rho1, but differ functionally in vivo: SAC7, but not BAG7, is involved in the control of Rho1-mediated activation of the PKC-MPK1 pathway. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239861  Cd Length: 225  Bit Score: 60.12  E-value: 1.17e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785405974   36 VPQVLRSCTDFVEEHGV-VDGIYRLCGIASNVHKLRQEFDmeRQPDLSK----DTYlqDVHCVSSLCKAYFRELPNPLLT 110
Cdd:cd04396     32 IPVVVAKCGVYLKENATeVEGIFRVAGSSKRIRELQLIFS--TPPDYGKsfdwDGY--TVHDAASVLRRYLNNLPEPLVP 107

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785405974  111 YQLYDKF--------------ADAVAIQLEEQRLIKIKE---VLKELPLPHYRTLEYLMRHLLRMASFSSQTNMHARNLA 173
Cdd:cd04396    108 LDLYEEFrnplrkrprilqymKGRINEPLNTDIDQAIKEyrdLITRLPNLNRQLLLYLLDLLAVFARNSDKNLMTASNLA 187

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|
gi 1785405974  174 IVWAPNLLRSKDIESSGfngtaafMEVRIQSIVVEFILTH 213
Cdd:cd04396    188 AIFQPGILSHPDHEMDP-------KEYKLSRLVVEFLIEH 220
RhoGAP_p85 cd04388
RhoGAP_p85: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present ...
 63-204 5.48e-09

RhoGAP_p85: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in the p85 isoforms of the regulatory subunit of the class IA PI3K (phosphatidylinositol 3'-kinase). This domain is also called Bcr (breakpoint cluster region protein) homology (BH) domain. Class IA PI3Ks are heterodimers, containing a regulatory subunit (p85) and a catalytic subunit (p110) and are activated by growth factor receptor tyrosine kinases (RTKs); this activation is mediated by the p85 subunit. p85 isoforms, alpha and beta, contain a C-terminal p110-binding domain flanked by two SH2 domains, an N-terminal SH3 domain, and a RhoGAP domain flanked by two proline-rich regions. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239853  Cd Length: 200  Bit Score: 57.58  E-value: 5.48e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785405974   63 ASNVHKLRQEFDMERQpdlSKDTYLQDVHCVSSLCKAYFRELPNPLLTYQLYDKFAD-AVAIQLEEQRLIKIKEVLKELP 141
Cdd:cd04388     42 SSSLTELRQILDCDAA---SVDLEQFDVAALADALKRYLLDLPNPVIPAPVYSEMISrAQEVQSSDEYAQLLRKLIRSPN 118

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1785405974  142 LPHYR--TLEYLMRHLLRMASFSSQTNMHARNLAIVWAPNLLRSKDIESSGFNGTAAFMEVRIQS 204
Cdd:cd04388    119 LPHQYwlTLQYLLKHFFRLCQSSSKNLLSARALAEIFSPLLFRFQPASSDSPEFHIRIIEVLITS 183
RhoGAP_ARHGAP19 cd04392
RhoGAP_ARHGAP19: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 45-218 8.38e-08

RhoGAP_ARHGAP19: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP19-like proteins. The function of ArhGAP19 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239857  Cd Length: 208  Bit Score: 54.39  E-value: 8.38e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785405974   45 DFVEEHGVVDGIYRLCGIASNVHKLRQEFDMERQPDLSKDTYlqDVHCVSSLCKAYFRELPNPLLT---YQLYDKFAD-- 119
Cdd:cd04392     18 EYLEKNLRVEGLFRKPGNSARQQELRDLLNSGTDLDLESGGF--HAHDCATVLKGFLGELPEPLLThahYPAHLQIADlc 95

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785405974  120 ------AVAIQLEEQRLIK-IKEVLKELPLPHYRTLEYLMRHLLRMASFSSQTNMHARNLAIVWAPNLLRSKDIESSGFN 192
Cdd:cd04392     96 qfdekgNKTSAPDKERLLEaLQLLLLLLPEENRNLLKLILDLLYQTAKHEDKNKMSADNLALLFTPHLICPRNLTPEDLH 175

                          170       180
                   ....*....|....*....|....*.
gi 1785405974  193 GTAAFMevriqSIVVEFILTHVEQLF 218
Cdd:cd04392    176 ENAQKL-----NSIVTFMIKHSQKLF 196
RhoGAP_fRGD2 cd04399
RhoGAP_fRGD2: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 64-218 1.75e-06

RhoGAP_fRGD2: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal RGD2-like proteins. Yeast Rgd2 is a GAP protein for Cdc42 and Rho5. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239864  Cd Length: 212  Bit Score: 50.41  E-value: 1.75e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785405974   64 SNVHKLRQEFDmERQPDLSKDTYLQDVH--CVSSLCKAYFRELPNPLLTYQLYD-------KFADAVAIQlEEQRLIKIK 134
Cdd:cd04399     51 KETHQLRNLLN-KPKKPDKEVIILKKFEpsTVASVLKLYLLELPDSLIPHDIYDlirslysAYPPSQEDS-DTARIQGLQ 128

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785405974  135 EVLKELPLPHYRTLEYLMRHLLR---MASFSSQTNMHARNLAIVWAPNLLRSKdIESSGfngtaaFMEVRIQSIVVEFIL 211
Cdd:cd04399    129 STLSQLPKSHIATLDAIITHFYRlieITKMGESEEEYADKLATSLSREILRPI-IESLL------TIGDKHGYKFFRDLL 201


                   ....*..
gi 1785405974  212 THVEQLF 218
Cdd:cd04399    202 THKDQIF 208
RhoGAP_OCRL1 cd04380
RhoGAP_OCRL1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 34-212 3.17e-04

RhoGAP_OCRL1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in OCRL1-like proteins. OCRL1 (oculocerebrorenal syndrome of Lowe 1)-like proteins contain two conserved domains: a central inositol polyphosphate 5-phosphatase domain and a C-terminal Rho GAP domain, this GAP domain lacks the catalytic residue and therefore maybe inactive. OCRL-like proteins are type II inositol polyphosphate 5-phosphatases that can hydrolyze lipid PI(4,5)P2 and PI(3,4,5)P3 and soluble Ins(1,4,5)P3 and Ins(1,3,4,5)P4, but their individual specificities vary. The functionality of the RhoGAP domain is still unclear. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239845  Cd Length: 220  Bit Score: 43.87  E-value: 3.17e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785405974   34 LEVPQVLRSCTDFVEEHGVVD-GIYRLCGIASNVHKLRQE----FDMERQPDLSKDtylqdVHCVSSLCKAYFRELPNPL 108
Cdd:cd04380     48 LSIPKEIWRLVDYLYTRGLAQeGLFEEPGLPSEPGELLAEirdaLDTGSPFNSPGS-----AESVAEALLLFLESLPDPI 122

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785405974  109 LTYQLYDKFADAVAIQLEEQR-LIKIKevlkeLPLPHYRTLEYLMRHLLRMASFSSQTNMHARNLAIVWAPNLLRSKdiE 187
Cdd:cd04380    123 IPYSLYERLLEAVANNEEDKRqVIRIS-----LPPVHRNVFVYLCSFLRELLSESADRGLDENTLATIFGRVLLRDP--P 195

                          170       180
                   ....*....|....*....|....*
gi 1785405974  188 SSGFNGTAAFMEvRIQSIVVEFILT 212
Cdd:cd04380    196 RAGGKERRAERD-RKRAFIEQFLLN 219
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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