BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8A (ZBTB8A); ZBTB8A, also called BTB/POZ and zinc-finger domain-containing factor or BTB/POZ and zinc-finger domains factor on chromosome 1 (BOZ-F1), is a novel proto-oncoprotein that stimulates cell proliferation. It binds to all the proximal GC boxes to repress transcription, and it inhibits p53 acetylation without affecting p53 stability. It may be involved in gastric adenocarcinoma cell differentiation, cancer invasion, and metastasis. ZBTB8A contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1838301061   3 ISSHQFHLLQQLNEQRRQDLFCDCNILVEGKVFKAHRNVLFASSGYFKMLLSQSSKETSQSTTATFQAFSPDTFTVILDF 82
Cdd:cd18329     1 ISSHQSRLLQQLDEQRKQELFCDCSILVEGQVFKAHRNVLFASSGYFKMLLSQNAKETGQPTVATFDVFSPDTFTIILDF 80

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1838301061  83 VYSGKLSLTGQNVIEVMSAASYLQMTDVISVCKTFI 118
Cdd:cd18329    81 VYSGKLSLTSQNVIEVMSAASYLQMTDVISVCKTFI 116

C2H2-type zinc-finger domain;

                          10        20
                  ....*....|....*....|....*
gi 1838301061 321 FKCPFCTHVVKRKADLKRHLRCHTG 345
Cdd:pfam13909   1 YKCSQCDYSTAWKSNLKRHLRKHTG 25

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8A (ZBTB8A); ZBTB8A, also called BTB/POZ and zinc-finger domain-containing factor or BTB/POZ and zinc-finger domains factor on chromosome 1 (BOZ-F1), is a novel proto-oncoprotein that stimulates cell proliferation. It binds to all the proximal GC boxes to repress transcription, and it inhibits p53 acetylation without affecting p53 stability. It may be involved in gastric adenocarcinoma cell differentiation, cancer invasion, and metastasis. ZBTB8A contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1838301061   3 ISSHQFHLLQQLNEQRRQDLFCDCNILVEGKVFKAHRNVLFASSGYFKMLLSQSSKETSQSTTATFQAFSPDTFTVILDF 82
Cdd:cd18329     1 ISSHQSRLLQQLDEQRKQELFCDCSILVEGQVFKAHRNVLFASSGYFKMLLSQNAKETGQPTVATFDVFSPDTFTIILDF 80

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1838301061  83 VYSGKLSLTGQNVIEVMSAASYLQMTDVISVCKTFI 118
Cdd:cd18329    81 VYSGKLSLTSQNVIEVMSAASYLQMTDVISVCKTFI 116

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1838301061   25 DCNILVEGKVFKAHRNVLFASSGYFKMLLSQSSKEtSQSTTATFQAFSPDTFTVILDFVYSGKLSLTGQNVIEVMSAASY 104
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKE-SDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELADY 79

                           90
                   ....*....|....*...
gi 1838301061  105 LQMTDVISVCKTFIKSSL 122
Cdd:smart00225  80 LQIPGLVELCEEFLLKLL 97

Zinc-finger double domain;

                          10        20
                  ....*....|....*....|....*.
gi 1838301061 335 DLKRHLRCHTGERPYPCEACGKRFSR 360
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26

FOG: Zn-finger [General function prediction only];

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1838301061 321 FKCPFCTHVVKRKADLKRHLRCHTGERPYPCEA--CGKRFSRLDHLSSHFRTIHQA 374
Cdd:COG5048    34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNN 89

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8A (ZBTB8A); ZBTB8A, also called BTB/POZ and zinc-finger domain-containing factor or BTB/POZ and zinc-finger domains factor on chromosome 1 (BOZ-F1), is a novel proto-oncoprotein that stimulates cell proliferation. It binds to all the proximal GC boxes to repress transcription, and it inhibits p53 acetylation without affecting p53 stability. It may be involved in gastric adenocarcinoma cell differentiation, cancer invasion, and metastasis. ZBTB8A contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1838301061   3 ISSHQFHLLQQLNEQRRQDLFCDCNILVEGKVFKAHRNVLFASSGYFKMLLSQSSKETSQSTTATFQAFSPDTFTVILDF 82
Cdd:cd18329     1 ISSHQSRLLQQLDEQRKQELFCDCSILVEGQVFKAHRNVLFASSGYFKMLLSQNAKETGQPTVATFDVFSPDTFTIILDF 80

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1838301061  83 VYSGKLSLTGQNVIEVMSAASYLQMTDVISVCKTFI 118
Cdd:cd18329    81 VYSGKLSLTSQNVIEVMSAASYLQMTDVISVCKTFI 116

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8B (ZBTB8B); ZBTB8B may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1838301061  10 LLQQLNEQRRQDLFCDCNILVEGKVFKAHRNVLFASSGYFKMLLSQSSKETSQSTTATFQAFSPDTFTVILDFVYSGKLS 89
Cdd:cd18330     5 LLGELNEQRKRDFFCDCSIIVEGRIFKAHRNILFANSGYFRALLIHYIQDSGRHSTASLDIVTSEAFSIILDFLYSGKLD 84

                          90       100
                  ....*....|....*....|....*....
gi 1838301061  90 LTGQNVIEVMSAASYLQMTDVISVCKTFI 118
Cdd:cd18330    85 LCSENVIEVMSAASYLQMTDVVNFCKGYI 113

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 10 (ZBTB10); ZBTB10, also called zinc finger protein RIN ZF, is an mRNA target of miR-27a and a transcriptional repressor of Specificity protein (Sp) expression. The microRNA-27a:ZBTB10-specificity protein pathway is involved in follicle stimulating hormone-induced VEGF, Cox2, and survivin expression in ovarian epithelial cancer cells. ZBTB10 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1838301061   4 SSHQFHLLQQLNEQRRQDLFCDCNILVEGKVFKAHRNVLFASSGYFKMLLSQSSKETSQSTTATF-QAFSPDTFTVILDF 82
Cdd:cd18201     2 NSYCYQLLQELNEQRKKGILCDVNIVVSGKVFRAHKNILVAGSRFFKTLYCFTNKESCDQTTVTHlDVVAVQGFSVILDF 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1838301061  83 VYSGKLSLTGQNVIEVMSAASYLQMTDVISVCKTFIKSSLD 123
Cdd:cd18201    82 MYSGNLVLTSQNAIEVMSVASYLQMTEVVQSCRNFIKDALN 122

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1838301061  14 LNEQRRQDLFCDCNILVEGKVFKAHRNVLFASSGYFKMLLSQSSKETSQSTTaTFQAFSPDTFTVILDFVYSGKLsLTGQ 93
Cdd:pfam00651   1 LNELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSVSEI-TLDDVSPEDFEALLEFMYTGKL-ISEE 78

                          90       100
                  ....*....|....*....|....*....
gi 1838301061  94 NVIEVMSAASYLQMTDVISVCKTFIKSSL 122
Cdd:pfam00651  79 NVDDLLAAADKLQIPSLVDKCEEFLIKSL 107

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1838301061  23 FCDCNILVEGKVFKAHRNVLFASSGYFKMLLSQSSKEtSQSTTATFQAFSPDTFTVILDFVYSGKLSLTGQNVIEVMSAA 102
Cdd:cd18186     1 LCDVTLVVGGREFPAHRAVLAARSPYFRAMFSSGMKE-SSSSEIELDDVSPEAFEALLDYIYTGELELSEENVEELLAAA 79

                  ...
gi 1838301061 103 SYL 105
Cdd:cd18186    80 DKL 82

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Influenza virus NS1A-binding protein (NS1-BP); NS1-BP is also called NS1-binding protein, aryl hydrocarbon receptor-associated protein 3 (ARA3), or IVNS1ABP. It is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through its kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control. NS1-BP contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1838301061   6 HQFHLLQQLNEQRRQDLFCDCNILVEGKVFKAHRNVLFASSGYFKMLLSQSSKETSQSTTaTFQAFSPDTFTVILDFVYS 85
Cdd:cd18306     1 HPESVLAKLNALRKNRQFCDVILQVGGHEIPAHRAVLACASPYLFELFSSDSDGESILTV-KLDGLDPDAVEVLVNYAYT 79

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1838301061  86 GKLSLTGQNVIEVMSAASYLQMTDVISVCKTFIKSSLD 123
Cdd:cd18306    80 SRLEVPADLVKSVYSAAKKLKMDRVKKACGDFLLEKLT 117

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18 (ZBTB18); ZBTB18 is also called 58 kDa repressor protein (RP58), transcriptional repressor RP58, translin-associated zinc finger protein 1 (TAZ-1), zinc finger protein 238 (ZNF238), or zinc finger protein C2H2-171. It is a sequence-specific transrepressor associated with heterochromatin. It plays a role in various developmental processes such as myogenesis and brain development. It specifically binds the consensus DNA sequence 5'-[AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes. ZBTB18 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1838301061   1 MEISSHQFHLLQQLNEQRRQDLFCDCNILVEGKVFKAHRNVLFASSGYFKML----LSQSSKETSQSTTATFQAFSpdtf 76
Cdd:cd18324     1 MEFPDHSRHLLQCLSEQRHQGFLCDCTVLVGDAQFRAHRAVLASCSMYFHLFykdqLDKRDIVHLNSDIVTAPAFA---- 76

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1838301061  77 tVILDFVYSGKLSLTGQNVIEVMSAASYLQMTDVISVCKTFIK----SSLDISEKEKDRyFSLSDKDGS 141
Cdd:cd18324    77 -LLLEFMYEGKLQFKDLPIEDVLAAASYLHMYDIVKVCKKKLKekatTEADSTKKEEDA-SSCSDKVES 143

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also called CUL3-interacting protein 1 (C3IP1) or DKIR homolog, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of the Wnt signaling pathway and ER-Golgi transport. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1838301061   5 SHQFHLLQQLNEQRRQDLFCDCNILVEGKVFKAHRNVLFASSGYFKMLLSQSSKETSQSTTaTFQAFSPDTFTVILDFVY 84
Cdd:cd18242     3 SHAKSILNTMNSLRKSNTLCDVTLRVEGKEFPAHRIVLAACSDYFCAMFTSEMSEKGKSEV-ELQGLTASTMEILLDFVY 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1838301061  85 SGKLSLTGQNVIEVMSAASYLQMTDVISVCKTFIKSSLDIS 125
Cdd:cd18242    82 TETVHVTVENVQELLPAACLLQLKGVKQACCEFLESQLDPS 122

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 17 (ZBTB17); ZBTB1 is also called c-Myc-interacting zinc finger protein 1 (Miz-1), zinc finger protein 151, or zinc finger protein 60. It is a poly-Cys2His2 zinc finger (ZF) transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. ZBTB17 has been implicated in cardiomyopathy and is important in cardiac stress response. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1838301061   6 HQFHLLQQLNEQRRQDLFCDCNILVEGKVFKAHRNVLFASSGYFKMLLsqsskeTSQSTTATFQAFSPDTFTVILDFVYS 85
Cdd:cd18206     5 HSQHVLEQLNQQRQLGLLCDCTFVVDGVDFKAHKAVLAACSEYFRMLF------VDQKDVVHLDISNAAGLGQVLEFMYT 78

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1838301061  86 GKLSLTGQNVIEVMSAASYLQMTDVISVCKTFI 118
Cdd:cd18206    79 AKLSLSPENVDDVLAVATFLQMQDIVTACHALK 111

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 1 protein (Hic-1); Hic-1, also called zinc finger and BTB domain-containing protein 29 (ZBTB29), is a sequence-specific transcriptional repressor that recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. It may act as a tumor suppressor, and is involved in regulatory loops modulating P53-dependent and E2F1-dependent cell survival, growth control, and stress responses. It also regulates intestinal immunity and homeostasis. Hic-1 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1838301061   3 ISSHQFHLLQQLNEQRRQDLFCDCNILVEGKVFKAHRNVLFASSGYFKMLLSQSSketsqSTTATFQAFSPDTFTVILDF 82
Cdd:cd18333     1 VPSHSRQLLLQLNTQRTKGFLCDVIIVVQNALFRAHKNILAASSVYLKSLVVHDN-----LINLDHEMVSPGIFRLILDY 75

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1838301061  83 VYSGKLS----LTGQNVIEVMSAASYLQMTDVISVCKTFIKSS 121
Cdd:cd18333    76 IYTGRLSegdpGSEQNLGAVLAAASYLQIPDLVALCKKKLKRN 118

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18, ZBTB42 and similar proteins; The family includes zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18 and ZBTB42. ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB18 is a sequence-specific transrepressor associated with heterochromatin. ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1838301061   1 MEISSHQFHLLQQLNEQRRQDLFCDCNILVEGKVFKAHRNVLFASSGYFKMLLSQSSkETSQSTTATFQAFSPDTFTVIL 80
Cdd:cd18194     1 MEFPEHSRQLLQCLREQRSQGFLCDCTVLVGSAQFPAHRAVLASCSMYFHLFYRDRL-DKRDLVRLNSDIVTAPAFGLLL 79

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1838301061  81 DFVYSGKLSLTGQNVIEVMSAASYLQMTDVISVCK 115
Cdd:cd18194    80 DFMYEGRLALRDLPVEDVLAAASYLHMYDIVKVCK 114

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 2 protein (Hic-2); Hic-2 is also called HIC1-related gene on chromosome 22 protein (HRG22), Hic-3, or zinc finger and BTB domain-containing protein 30 (ZBTB30). It is a homolog of tumor suppressor Hic-1. It functions as a transcriptional regulator. It is a dosage-dependent regulator of cardiac development located within the distal 22q11 deletion syndrome region. Hic-2 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1838301061   3 ISSHQFHLLQQLNEQRRQDLFCDCNILVEGKVFKAHRNVLFASSGYFKMLLSQSSKETSQSTTAtfqafSPDTFTVILDF 82
Cdd:cd18334     1 LPNHAKQLLLQLNQQRAKGFLCDVIIVVENALFRAHKNILAASSMYFKSLVLHDNLINLDTDMV-----NPTVFRQILDF 75

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1838301061  83 VYSGKLSLTGQ----NVIEVMSAASYLQMTDVISVCKTFIK 119
Cdd:cd18334    76 IYTGKLLTSDQpgeqNFNALLTAASYLQLHDLAALCRKKLK 116

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 38 (KLHL38); KLHL38 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The KLHL38 gene is significantly up-regulated during diapause, a temporary arrest of development during early ontogeny. It may also function in preadipocyte differentiation in the chicken. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1838301061  10 LLQQLNEQRRQDLFCDCNILVEGKVFKAHRNVLFASSGYFKMLLSQSSKETSQSTTaTFQAFSPDTFTVILDFVYSGKLS 89
Cdd:cd18268    10 LLRQLNSLRQERILTDVILCTGDKEIPCHRNVLASSSPYFRAMFCNNFRESSQAKV-DLKGIDSDVLDQIVDYVYTGEIL 88

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1838301061  90 LTGQNVIEVMSAASYLQMTDVISVCKTFIKSSL 122
Cdd:cd18268    89 ITRDNVLPLMEAASMLQYPKLFEACSLYLQDQL 121

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer proteins, Hic-1 and Hic-2; The family includes hypermethylated in cancer proteins, Hic-1 and Hic-2. Hic-1 is a sequence-specific transcriptional repressor that recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. Hic-2 is a homolog of tumor suppressor Hic-1 that functions as a transcriptional regulator. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1838301061   4 SSHQFHLLQQLNEQRRQDLFCDCNILVEGKVFKAHRNVLFASSGYFKMLLSqsskeTSQSTTATFQAFSPDTFTVILDFV 83
Cdd:cd18216     1 PSHATQLLLQLNNQRTKGFLCDVIIVVENSLFRAHKNVLAASSGYFKSLVL-----HDNLIHLDQDMVSPTVFQQILDFI 75

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1838301061  84 YSGKLSLTGQ---NVIEVMSAASYLQMTDVISVCKTFIK 119
Cdd:cd18216    76 YTGKLLDSLFeepNLSEVLAAANYLQLPDLAALCRSKLK 114

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 2 (NAC-2); NAC-2, also called BTB/POZ domain-containing protein 14A (BTBD14A) or repressor with BTB domain and BEN domain (RBB), is a novel transcription repressor through its association with the NuRD complex. It recruits the NuRD complex to the promoter of MDM2, leading to the repression of MDM2 transcription and subsequent stability of p53/TP53. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1838301061   1 MEISSHQFHLLQQLNEQRRQDLFCDCNILVEGKVFKAHRNVLFASSGYFKMLLSQSSKETSQSTTATfqafSPDTFTVIL 80
Cdd:cd18289     7 IEIPNFGNTVLGCLNEQRLMGLYCDVSIVVKGQAFKAHRAVLAASSLYFRDLFSGNSKSAFELPATV----PPACFQQIL 82

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1838301061  81 DFVYSGKLSLTGQNVIEVMSAASYLQMTDVI 111
Cdd:cd18289    83 SFCYTGKLTMAASEQLVVMYTAGFLQIQHIV 113

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 42 (ZBTB42); ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. It is enriched in skeletal muscles, especially at the neuromuscular junction. A ZBTB42 mutation has been identified to define a novel lethal congenital contracture syndrome (LCCS6), a lethal autosomal recessive form of arthrogryposis multiplex congenita (AMC). ZBTB42 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1838301061   1 MEISSHQFHLLQQLNEQRRQDLFCDCNILVEGKVFKAHRNVLFASSGYFKMLLSQSSKETSQSTTATFQAFSPDTFTVIL 80
Cdd:cd18956     1 MEFPEHGGRLLGRLRQQRELGFLCDCTVLVGDARFPAHRAVLAACSVYFHLFYRDRPAGGRDTVRLNGDIVTAPAFGRLL 80

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1838301061  81 DFVYSGKLSLTGQNVIEVMSAASYLQMTDVISVCK 115
Cdd:cd18956    81 DFMYEGRLDLRSLPVEDVLAAASYLHMYDIVKVCK 115

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in telomere zinc finger-associated protein (TZAP); TZAP is also called Krueppel-related zinc finger protein 3 (KR3), zinc finger and BTB domain-containing protein 48 (ZBTB48), or zinc finger protein 855 (ZNF855). It is a vertebrate telomere-binding protein involved in telomere length control. It directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat. TZAP also acts as a transcription regulator that binds to promoter regions. It is a transcriptional activator of alternate reading frame (ARF) gene. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1838301061   6 HQFHLLQQLNEQRRQDLFCDCNILVEGKVFKAHRNVLFASSGYFKMLLSQSSketsQSTTATFQAFSpDTFTVILDFVYS 85
Cdd:cd18232     1 HSVKVLQALNKQREEGQYCDATLDVGGRVFKAHWSVLACCSHFFQSLYGDGT----SGSVVLPESFA-EVFGLLLDFFYT 75

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1838301061  86 GKLSLTGQNVIEVMSAASYLQMTDVISVCKTF 117
Cdd:cd18232    76 GELALTRENRDRVLLAAKELRVPEAVELCQRF 107

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7A (ZBTB7A); ZBTB7A is also called factor binding IST protein 1 (FBI-1), factor that binds to inducer of short transcripts protein 1, HIV-1 1st-binding protein 1, Leukemia/lymphoma-related factor (LRF), POZ and Krueppel erythroid myeloid ontogenic factor, POK erythroid myeloid ontogenic factor, Pokemon, TTF-I-interacting peptide 21 (TIP21), or zinc finger protein 857A (ZNF857A). It is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. It has been implicated in carcinogenesis and cell differentiation and development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1838301061   6 HQFHLLQQLNEQRRQDLFCDCNILVEGKVFKAHRNVLFASSGYFKMLLSqSSKETSQSTTATFQAFSPDTFTVILDFVYS 85
Cdd:cd18326     8 HSSDILSSLNEQRTQGLLCDVVILVEGREFPTHRSVLAACSQYFKKLFT-SGAVVDQQNVYEIDFVSAEALTALLDFAYT 86

                          90       100
                  ....*....|....*....|....*....
gi 1838301061  86 GKLSLTGQNVIEVMSAASYLQMTDVISVC 114
Cdd:cd18326    87 ATLTVSTSNVGDILSAARLLEIPAVSHVC 115

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7 (ZBTB7); There are three ZBTB7 isoforms: ZBTB7A, ZBTB7B, and ZBTB7C. ZBTB7A is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. ZBTB7B is a transcriptional regulator of extracellular matrix gene expression. ZBTB7C is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. ZBTB7 isoforms contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1838301061   6 HQFHLLQQLNEQRRQDLFCDCNILVEGKVFKAHRNVLFASSGYFKMLLSqSSKETSQSTTATFQAFSPDTFTVILDFVYS 85
Cdd:cd18198     8 HSSEILSGLNEQRTQGLLCDVVILVQGREYRTHRSVLAACSQYFKKLFT-SGAVVDQQNVYEIDFVSPEALTALLEFAYT 86

                          90       100
                  ....*....|....*....|....*....
gi 1838301061  86 GKLSLTGQNVIEVMSAASYLQMTDVISVC 114
Cdd:cd18198    87 ATLTVSTANVGDILSAARLLEIPCVSHVC 115

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 also targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1838301061   5 SHQFHLLQQLNEQRRQDLFCDCNILVEGKVFKAHRNVLFASSGYFKMLLSQSSKEtSQSTTATFQAFSPDTFTVILDFVY 84
Cdd:cd18250     3 AHALHLLRGLSELRAERKFFDVTLCAGGREFPCHRTVLAAASSYFRAMFAGELRE-SRADRVVLHGVSAEILGLLLDFSY 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1838301061  85 SGKLSLTGQNVIEVMSAASYLQMTDVISVCKTFIKSSLDIS 125
Cdd:cd18250    82 TGRVTVTQDNVEALLRAADLFQFPSVKEACCAYLQQRLDVS 122

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell CLL/lymphoma 6 member B protein (BCL6B); BCL6B is also called Bcl6-associated zinc finger protein, zinc finger protein 62, or zinc finger and BTB domain-containing protein 28 (ZBTB28). It is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. BCL6B plays an important role as a potential tumor suppressor in gastric cancer; it is found preferentially methylated in gastric cancer. It also inhibits both colorectal cancer growth and hepatocellular carcinoma metastases. BCL6B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1838301061   6 HQFHLLQQLNEQRRQDLFCDCNILVEGKVFKAHRNVLFASSGYFKMLLSQSSKETSQSTTATfQAFSPDTFTVILDFVYS 85
Cdd:cd18332     2 HSSDVLLNLNELRKRDILTDVTLLVGGTPLRAHKAVLIACSGFFYSIFSGRVGEGVSVLTLP-SGLEARGFQLLLDFMYT 80

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1838301061  86 GKLSLTGQNVIEVMSAASYLQMTDVISVCKTFIK 119
Cdd:cd18332    81 SRLPLTPRTVPAVLAAATYLQMEHVVETCRRFIQ 114

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing proteins KBTBD6 and KBTBD7; KBTBD6 and KBTBD7 are substrate adaptors of a cullin-3 RING ubiquitin ligase complex that mediates ubiquitylation and proteasomal degradation of T-lymphoma and metastasis gene 1 (TIAM1), a RAC1-specific guanine exchange factor (GEF), by cooperating with gamma-aminobutyric acid receptor-associated proteins (GABARAP). KBTBD7 may also act as a new transcriptional activator in mitogen-activated protein kinase (MAPK) signaling. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1838301061   1 MEISSHQFHLLQQLNEQRRQDLFCDCNILVE--------GKVFKAHRNVLFASSGYFKMLLSQSSKETSQSTTaTFQAFS 72
Cdd:cd18273     4 LEDAAHARALLAQLKSFYDARLLTDVTIEVNgpgsgpgsGRLFPCNRNVLAAASPYFKSMFTGGLYESKQETV-TIHDVD 82

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1838301061  73 PDTFTVILDFVYSGKLSLTGQNVIEVMSAASYLQMTDVISVCKTFIKSSLDIS 125
Cdd:cd18273    83 SESMALIIDYCYTGRVTLSEANVQRLYAAANMLQLEYVREACASFLARRLDLS 135

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 1 (BACH1); BACH1, also called BTB-basic leucine zipper transcription factor 1, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. It can act as repressor or activator. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. It is also a negative regulator of nuclear factor erythroid 2-related factor 2 (Nrf2) that controls antioxidant response elements (ARE)-dependent gene expressions. BACH1 binds to NF-E2 binding sites in vitro, and plays important roles in coordinating transcription activation and repression by MafK. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1838301061   2 EISSHQFHLLQQLNEQRRQDLFCDCNILVEGKVFKAHRNVLFASSGYF-KMLLSQSSKE--TSQSTTATFQAFSPdtftv 78
Cdd:cd18277     6 ESSVHSTNVLLSLNDQRKKDVLCDVTILVEGQRFRAHRSVLAACSSYFhSRIVGQADAElnITLPEEVTVKGFEP----- 80