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Conserved domains on  [gi|1839551037|ref|XP_034118079|]
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uncharacterized protein LOC117577088 [Drosophila albomicans]

Protein Classification

LamG domain-containing protein( domain architecture ID 366259)

LamG (Laminin G) domain-containing protein may serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LamG super family cl22861
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 159-269 1.00e-13

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


The actual alignment was detected with superfamily member cd00152:

Pssm-ID: 473984  Cd Length: 201  Bit Score: 69.99  E-value: 1.00e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839551037 159 PELEQFTLCFWMRFTNHSGDHVMFTYEAGKEQREIQIWVANAQNSSFLsmaIKGQQMyRLNYPLKMRQWHHMCSSWNGKT 238
Cdd:cd00152    28 KPLQAFTLCLWVYTDLSTREYSLFSYATKGQDNELLLYKEKDGGYSLY---IGGKEV-TFKVPESDGAWHHICVTWESTS 103

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1839551037 239 GEWQVWLKAERIGRGfhnSL-VGHKIPAKGKL 269
Cdd:cd00152   104 GIAELWVNGKLSVRK---SLkKGYTVGPGGSI 132
 
Name Accession Description Interval E-value
PTX cd00152
Pentraxins are plasma proteins characterized by their pentameric discoid assembly and their ...
 159-269 1.00e-13

Pentraxins are plasma proteins characterized by their pentameric discoid assembly and their Ca2+ dependent ligand binding, such as Serum amyloid P component (SAP) and C-reactive Protein (CRP), which are cytokine-inducible acute-phase proteins implicated in innate immunity. CRP binds to ligands containing phosphocholine, SAP binds to amyloid fibrils, DNA, chromatin, fibronectin, C4-binding proteins and glycosaminoglycans. "Long" pentraxins have N-terminal extensions to the common pentraxin domain; one group, the neuronal pentraxins, may be involved in synapse formation and remodeling, and they may also be able to form heteromultimers.


Pssm-ID: 238086  Cd Length: 201  Bit Score: 69.99  E-value: 1.00e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839551037 159 PELEQFTLCFWMRFTNHSGDHVMFTYEAGKEQREIQIWVANAQNSSFLsmaIKGQQMyRLNYPLKMRQWHHMCSSWNGKT 238
Cdd:cd00152    28 KPLQAFTLCLWVYTDLSTREYSLFSYATKGQDNELLLYKEKDGGYSLY---IGGKEV-TFKVPESDGAWHHICVTWESTS 103

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1839551037 239 GEWQVWLKAERIGRGfhnSL-VGHKIPAKGKL 269
Cdd:cd00152   104 GIAELWVNGKLSVRK---SLkKGYTVGPGGSI 132
PTX smart00159
Pentraxin / C-reactive protein / pentaxin family; This family form a doscoid pentameric ...
 159-269 2.95e-09

Pentraxin / C-reactive protein / pentaxin family; This family form a doscoid pentameric structure. Human serum amyloid P demonstrates calcium-mediated ligand-binding.


Pssm-ID: 128463  Cd Length: 206  Bit Score: 57.28  E-value: 2.95e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839551037  159 PELEQFTLCFWMRFTNHSGDHVMFTYEAGKEQREIQIWVAnaQNSSFlSMAIKGQQMyRLNYPLKMRQWHHMCSSWNGKT 238
Cdd:smart00159  28 KPLQAFTVCLWFYSDLSPRGYSLFSYATKGQDNELLLYKE--KQGEY-SLYIGGKKV-QFPVPESDGKWHHICTTWESSS 103

                           90       100       110
                   ....*....|....*....|....*....|..
gi 1839551037  239 GEWQVWLKAER-IGRGFHnslVGHKIPAKGKL 269
Cdd:smart00159 104 GIAELWVDGKPgVRKGLA---KGYTVKPGGSI 132
Pentaxin pfam00354
Pentaxin family; Pentaxins are also known as pentraxins.
 142-245 3.75e-07

Pentaxin family; Pentaxins are also known as pentraxins.


Pssm-ID: 278768  Cd Length: 194  Bit Score: 50.88  E-value: 3.75e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839551037 142 KKFAFNQDGVVEYNNELPELEQ----FTLCFWMrFTNHSGDHVMFTYEAGKEQREIQIWVANAQNSSFlsmAIKGQQMYR 217
Cdd:pfam00354   1 KVFVFPKESDTSYVSLIPELEKplqnFTLCLRF-YTDLSRSYSLFSYATKKQDNELLIFKEKDGEYSF---YVGGAEVLF 76

                          90       100
                  ....*....|....*....|....*...
gi 1839551037 218 LNYPLKMrQWHHMCSSWNGKTGEWQVWL 245
Cdd:pfam00354  77 KVSEIPV-APVHICTSWESSSGIAEFWV 103
 
Name Accession Description Interval E-value
PTX cd00152
Pentraxins are plasma proteins characterized by their pentameric discoid assembly and their ...
 159-269 1.00e-13

Pentraxins are plasma proteins characterized by their pentameric discoid assembly and their Ca2+ dependent ligand binding, such as Serum amyloid P component (SAP) and C-reactive Protein (CRP), which are cytokine-inducible acute-phase proteins implicated in innate immunity. CRP binds to ligands containing phosphocholine, SAP binds to amyloid fibrils, DNA, chromatin, fibronectin, C4-binding proteins and glycosaminoglycans. "Long" pentraxins have N-terminal extensions to the common pentraxin domain; one group, the neuronal pentraxins, may be involved in synapse formation and remodeling, and they may also be able to form heteromultimers.


Pssm-ID: 238086  Cd Length: 201  Bit Score: 69.99  E-value: 1.00e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839551037 159 PELEQFTLCFWMRFTNHSGDHVMFTYEAGKEQREIQIWVANAQNSSFLsmaIKGQQMyRLNYPLKMRQWHHMCSSWNGKT 238
Cdd:cd00152    28 KPLQAFTLCLWVYTDLSTREYSLFSYATKGQDNELLLYKEKDGGYSLY---IGGKEV-TFKVPESDGAWHHICVTWESTS 103

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1839551037 239 GEWQVWLKAERIGRGfhnSL-VGHKIPAKGKL 269
Cdd:cd00152   104 GIAELWVNGKLSVRK---SLkKGYTVGPGGSI 132
PTX smart00159
Pentraxin / C-reactive protein / pentaxin family; This family form a doscoid pentameric ...
 159-269 2.95e-09

Pentraxin / C-reactive protein / pentaxin family; This family form a doscoid pentameric structure. Human serum amyloid P demonstrates calcium-mediated ligand-binding.


Pssm-ID: 128463  Cd Length: 206  Bit Score: 57.28  E-value: 2.95e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839551037  159 PELEQFTLCFWMRFTNHSGDHVMFTYEAGKEQREIQIWVAnaQNSSFlSMAIKGQQMyRLNYPLKMRQWHHMCSSWNGKT 238
Cdd:smart00159  28 KPLQAFTVCLWFYSDLSPRGYSLFSYATKGQDNELLLYKE--KQGEY-SLYIGGKKV-QFPVPESDGKWHHICTTWESSS 103

                           90       100       110
                   ....*....|....*....|....*....|..
gi 1839551037  239 GEWQVWLKAER-IGRGFHnslVGHKIPAKGKL 269
Cdd:smart00159 104 GIAELWVDGKPgVRKGLA---KGYTVKPGGSI 132
Pentaxin pfam00354
Pentaxin family; Pentaxins are also known as pentraxins.
 142-245 3.75e-07

Pentaxin family; Pentaxins are also known as pentraxins.


Pssm-ID: 278768  Cd Length: 194  Bit Score: 50.88  E-value: 3.75e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839551037 142 KKFAFNQDGVVEYNNELPELEQ----FTLCFWMrFTNHSGDHVMFTYEAGKEQREIQIWVANAQNSSFlsmAIKGQQMYR 217
Cdd:pfam00354   1 KVFVFPKESDTSYVSLIPELEKplqnFTLCLRF-YTDLSRSYSLFSYATKKQDNELLIFKEKDGEYSF---YVGGAEVLF 76

                          90       100
                  ....*....|....*....|....*...
gi 1839551037 218 LNYPLKMrQWHHMCSSWNGKTGEWQVWL 245
Cdd:pfam00354  77 KVSEIPV-APVHICTSWESSSGIAEFWV 103
Laminin_G_3 pfam13385
Concanavalin A-like lectin/glucanases superfamily; This domain belongs to the Concanavalin ...
 146-300 2.42e-03

Concanavalin A-like lectin/glucanases superfamily; This domain belongs to the Concanavalin A-like lectin/glucanases superfamily.


Pssm-ID: 463865 [Multi-domain]  Cd Length: 151  Bit Score: 38.90  E-value: 2.42e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839551037 146 FNQDGVVEYNNELPELEQFTLCFWMRFTNHSGDHVMFTYEAGKEQREIQIWvanaqNSSFLSMAIKGQQMY----RLNYP 221
Cdd:pfam13385   1 DGGSDYVTLPDALLPTSDFTVSAWVKPDSLPGWARAIISSSGGGGYSLGLD-----GDGRLRFAVNGGNGGwdtvTSGAS 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839551037 222 LKMRQWHHMCSSWNGktGEWQVWLKAERIGRGfhnSLVGHKIPAKGKLRSGGSSITGEVshglHFEVTL--VQIYRVALS 299
Cdd:pfam13385  76 VPLGQWTHVAVTYDG--GTLRLYVNGVLVGSS---TLTGGPPPGTGGPLYIGRSPGGDD----YFNGLIdeVRIYDRALS 146


                  .
gi 1839551037 300 A 300
Cdd:pfam13385 147 A 147
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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