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Conserved domains on  [gi|1898583630|ref|XP_035863512|]
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ras-GEF domain-containing family member 1C [Sander lucioperca]

Protein Classification

Ras-GEF domain-containing protein( domain architecture ID 10153535)

Ras guanine nucleotide exchange factor (Ras-GEF) domain-containing protein activates Ras-like small GTPases by mediating the replacement of GDP with GTP

CATH:  1.10.840.10
Gene Ontology:  GO:0007264|GO:0005085
PubMed:  7786285
SCOP:  4001268

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
RasGEF pfam00617
RasGEF domain; Guanine nucleotide exchange factor for Ras-like small GTPases.
222-416 5.85e-65

RasGEF domain; Guanine nucleotide exchange factor for Ras-like small GTPases.


:

Pssm-ID: 459872  Cd Length: 179  Bit Score: 207.83  E-value: 5.85e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898583630 222 LAQQLTHVELEHLRHIGPEEFVQAFVQKDpldgtqpcfsDQKKKTSNLEAYVRWFNRLCYLVATEICMPAKKKQRAQVIE 301
Cdd:pfam00617   2 LARQLTLIEFELFRKIKPRELLGSAWSKK----------DKKENSPNIEAMIARFNKLSNWVASEILSEEDLKKRAKVIK 71
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898583630 302 FFIDVARECFNIGNFNSLMAIISGMNMSPVSRLKKTWGK--AKTAKFF-ILEHQMDPTGNFYNYRTALRgaahrsrtans 378
Cdd:pfam00617  72 KFIKIAEHCRELNNFNSLMAILSGLNSSPISRLKKTWELvsKKYKKTLeELEKLMSPSRNFKNYREALS----------- 140
                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1898583630 379 NRERIVIPFFSLLIKDIYFLNEGCANRLPNGHVNFEKF 416
Cdd:pfam00617 141 SASPPCIPFLGLYLTDLTFIEEGNPDFLEGGLINFEKR 178
REM cd06224
Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also ...
53-171 1.42e-17

Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately N-terminal to the RasGef (Cdc25-like) domain. REM contacts the GTPase and is assumed to participate in the catalytic activity of the exchange factor. Proteins with the REM domain include Sos1 and Sos2, which relay signals from tyrosine-kinase mediated signalling to Ras, RasGRP1-4, RasGRF1,2, CNrasGEF, and RAP-specific nucleotide exchange factors, to name a few.


:

Pssm-ID: 100121  Cd Length: 122  Bit Score: 78.61  E-value: 1.42e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898583630  53 SLDTLIHNLVPTaDYYPEKAYVFTFLLSARLFIPPPELLSRLCELCIKQQQLDQSPLDT--AKVRKFGPKILQLLTEWTE 130
Cdd:cd06224     1 TLEALIEHLTST-FDMPDPSFVSTFLLTYRSFTTPTELLEKLIERYEIAPPENLEYNDWdkKKSKPIRLRVLNVLRTWVE 79
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1898583630 131 TFPSDF-RDEKMVGHFKDIIHRIAPCDEAYWKTLNQVLQKLS 171
Cdd:cd06224    80 NYPYDFfDDEELLELLEEFLNRLVQEGALLQELKKLLRKLLK 121
 
Name Accession Description Interval E-value
RasGEF pfam00617
RasGEF domain; Guanine nucleotide exchange factor for Ras-like small GTPases.
222-416 5.85e-65

RasGEF domain; Guanine nucleotide exchange factor for Ras-like small GTPases.


Pssm-ID: 459872  Cd Length: 179  Bit Score: 207.83  E-value: 5.85e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898583630 222 LAQQLTHVELEHLRHIGPEEFVQAFVQKDpldgtqpcfsDQKKKTSNLEAYVRWFNRLCYLVATEICMPAKKKQRAQVIE 301
Cdd:pfam00617   2 LARQLTLIEFELFRKIKPRELLGSAWSKK----------DKKENSPNIEAMIARFNKLSNWVASEILSEEDLKKRAKVIK 71
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898583630 302 FFIDVARECFNIGNFNSLMAIISGMNMSPVSRLKKTWGK--AKTAKFF-ILEHQMDPTGNFYNYRTALRgaahrsrtans 378
Cdd:pfam00617  72 KFIKIAEHCRELNNFNSLMAILSGLNSSPISRLKKTWELvsKKYKKTLeELEKLMSPSRNFKNYREALS----------- 140
                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1898583630 379 NRERIVIPFFSLLIKDIYFLNEGCANRLPNGHVNFEKF 416
Cdd:pfam00617 141 SASPPCIPFLGLYLTDLTFIEEGNPDFLEGGLINFEKR 178
RasGEF smart00147
Guanine nucleotide exchange factor for Ras-like small GTPases;
215-468 1.92e-61

Guanine nucleotide exchange factor for Ras-like small GTPases;


Pssm-ID: 214539  Cd Length: 242  Bit Score: 200.93  E-value: 1.92e-61
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898583630  215 ICNDPYTLAQQLTHVELEHLRHIGPEEFVQAFVQKDpldgtqpcfSDQKKKTSNLEAYVRWFNRLCYLVATEICMPAKKK 294
Cdd:smart00147   2 LLLDPKELAEQLTLLDFELFRKIDPSELLGSVWGKR---------SKKSPSPLNLEAFIRRFNEVSNWVATEILKQTTPK 72
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898583630  295 QRAQVIEFFIDVARECFNIGNFNSLMAIISGMNMSPVSRLKKTWGK--AKTAKFFI-LEHQMDPTGNFYNYRTALRGAAH 371
Cdd:smart00147  73 DRAELLSKFIQVAKHCRELNNFNSLMAIVSALSSSPISRLKKTWEKlpSKYKKLFEeLEELLSPERNYKNYREALSSCNL 152
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898583630  372 rsrtansnreRIVIPFFSLLIKDIYFLNEGCANRLPNGHVNFEKFVELARQVGEFMTWKQVECPFEEDRAILHYLHTAPI 451
Cdd:smart00147 153 ----------PPCIPFLGVLLKDLTFIDEGNPDFLENGLVNFEKRRQIAEILREIRQLQSQPYNLRPNRSDIQSLLQQLL 222
                          250       260
                   ....*....|....*....|
gi 1898583630  452 F---SEDGLYLASYESESPE 468
Cdd:smart00147 223 DhldEEEELYQLSLKIEPRV 242
RasGEF cd00155
Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of ...
216-463 1.09e-58

Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. Guanine-nucleotide-exchange factors (GEFs) positively regulate these GTP-binding proteins in response to a variety of signals. GEFs catalyze the dissociation of GDP from the inactive GTP-binding proteins. GTP can then bind and induce structural changes that allow interaction with effectors.


Pssm-ID: 238087 [Multi-domain]  Cd Length: 237  Bit Score: 193.62  E-value: 1.09e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898583630 216 CNDPYTLAQQLTHVELEHLRHIGPEEFVQA-FVQKDPLDGTQPcfsdqkkktsNLEAYVRWFNRLCYLVATEICMPAKKK 294
Cdd:cd00155     3 SLDPKELAEQLTLLDFELFRKIEPFELLGSlWSKKDKNIHLSP----------NLERFIERFNNLSNWVASEILLCTNPK 72
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898583630 295 QRAQVIEFFIDVARECFNIGNFNSLMAIISGMNMSPVSRLKKTWGK--AKTAKFF-ILEHQMDPTGNFYNYRTALRgaah 371
Cdd:cd00155    73 KRARLLSKFIQVAKHCRELNNFNSLMAIVSALSSSPISRLKKTWEVlsSKLKKLFeELEELVDPSRNFKNYRKLLK---- 148
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898583630 372 rsrtaNSNRERIVIPFFSLLIKDIYFLNEGCANRLPNGHVNFEKFVELARQVGEFMTWKQVECPFEEDRAILHYLHT--A 449
Cdd:cd00155   149 -----SVGPNPPCVPFLGVYLKDLTFLHEGNPDFLEGNLVNFEKRRKIAEILREIRQLQSNSYELNRDEDILAFLWKllE 223
                         250
                  ....*....|....
gi 1898583630 450 PIFSEDGLYLASYE 463
Cdd:cd00155   224 LILNEDELYELSLE 237
REM cd06224
Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also ...
53-171 1.42e-17

Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately N-terminal to the RasGef (Cdc25-like) domain. REM contacts the GTPase and is assumed to participate in the catalytic activity of the exchange factor. Proteins with the REM domain include Sos1 and Sos2, which relay signals from tyrosine-kinase mediated signalling to Ras, RasGRP1-4, RasGRF1,2, CNrasGEF, and RAP-specific nucleotide exchange factors, to name a few.


Pssm-ID: 100121  Cd Length: 122  Bit Score: 78.61  E-value: 1.42e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898583630  53 SLDTLIHNLVPTaDYYPEKAYVFTFLLSARLFIPPPELLSRLCELCIKQQQLDQSPLDT--AKVRKFGPKILQLLTEWTE 130
Cdd:cd06224     1 TLEALIEHLTST-FDMPDPSFVSTFLLTYRSFTTPTELLEKLIERYEIAPPENLEYNDWdkKKSKPIRLRVLNVLRTWVE 79
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1898583630 131 TFPSDF-RDEKMVGHFKDIIHRIAPCDEAYWKTLNQVLQKLS 171
Cdd:cd06224    80 NYPYDFfDDEELLELLEEFLNRLVQEGALLQELKKLLRKLLK 121
RasGEF_N pfam00618
RasGEF N-terminal motif; A subset of guanine nucleotide exchange factor for Ras-like small ...
49-142 2.32e-11

RasGEF N-terminal motif; A subset of guanine nucleotide exchange factor for Ras-like small GTPases appear to possess this motif/domain N-terminal to the RasGef (Cdc25-like) domain.


Pssm-ID: 459873  Cd Length: 104  Bit Score: 60.40  E-value: 2.32e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898583630  49 ITSASLDTLIHNLVPTaDYYPEKAYVFTFLLSARLFIPPPELLSRLCELCIKQQQLDQSPLDTAKVRKFGP---KILQLL 125
Cdd:pfam00618   2 VKAGTLEKLVEYLTST-RIMLDDSFLSTFLLTYRSFTTPAELLELLIERYNIPPPLDLSSDSYWISKKTLPiriRVLSVL 80
                          90
                  ....*....|....*..
gi 1898583630 126 TEWTETFPSDFRDEKMV 142
Cdd:pfam00618  81 RHWVENYFSDFNDDPVL 97
RasGEFN smart00229
Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif; A subset of guanine ...
45-139 9.56e-11

Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif; A subset of guanine nucleotide exchange factor for Ras-like small GTPases appear to possess this domain N-terminal to the RasGef (Cdc25-like) domain. The recent crystal structureof Sos shows that this domain is alpha-helical and plays a "purely structural role" (Nature 394, 337-343).


Pssm-ID: 214571  Cd Length: 127  Bit Score: 59.27  E-value: 9.56e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898583630   45 DGPPITSASLDTLIHNLVPTaDYYPEKAYVFTFLLSARLFIPPPELLSRLCEL--CIKQQQLDQSPLDTAKVRKfgpKIL 122
Cdd:smart00229   1 DGGLIKGGTLEALIEHLTEA-FDKADPSFVETFLLTYRSFITTQELLQLLLYRynAIPPESWVEEKVNPRRVKN---RVL 76
                           90
                   ....*....|....*..
gi 1898583630  123 QLLTEWTETFPSDFRDE 139
Cdd:smart00229  77 NILRTWVENYWEDFEDD 93
 
Name Accession Description Interval E-value
RasGEF pfam00617
RasGEF domain; Guanine nucleotide exchange factor for Ras-like small GTPases.
222-416 5.85e-65

RasGEF domain; Guanine nucleotide exchange factor for Ras-like small GTPases.


Pssm-ID: 459872  Cd Length: 179  Bit Score: 207.83  E-value: 5.85e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898583630 222 LAQQLTHVELEHLRHIGPEEFVQAFVQKDpldgtqpcfsDQKKKTSNLEAYVRWFNRLCYLVATEICMPAKKKQRAQVIE 301
Cdd:pfam00617   2 LARQLTLIEFELFRKIKPRELLGSAWSKK----------DKKENSPNIEAMIARFNKLSNWVASEILSEEDLKKRAKVIK 71
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898583630 302 FFIDVARECFNIGNFNSLMAIISGMNMSPVSRLKKTWGK--AKTAKFF-ILEHQMDPTGNFYNYRTALRgaahrsrtans 378
Cdd:pfam00617  72 KFIKIAEHCRELNNFNSLMAILSGLNSSPISRLKKTWELvsKKYKKTLeELEKLMSPSRNFKNYREALS----------- 140
                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1898583630 379 NRERIVIPFFSLLIKDIYFLNEGCANRLPNGHVNFEKF 416
Cdd:pfam00617 141 SASPPCIPFLGLYLTDLTFIEEGNPDFLEGGLINFEKR 178
RasGEF smart00147
Guanine nucleotide exchange factor for Ras-like small GTPases;
215-468 1.92e-61

Guanine nucleotide exchange factor for Ras-like small GTPases;


Pssm-ID: 214539  Cd Length: 242  Bit Score: 200.93  E-value: 1.92e-61
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898583630  215 ICNDPYTLAQQLTHVELEHLRHIGPEEFVQAFVQKDpldgtqpcfSDQKKKTSNLEAYVRWFNRLCYLVATEICMPAKKK 294
Cdd:smart00147   2 LLLDPKELAEQLTLLDFELFRKIDPSELLGSVWGKR---------SKKSPSPLNLEAFIRRFNEVSNWVATEILKQTTPK 72
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898583630  295 QRAQVIEFFIDVARECFNIGNFNSLMAIISGMNMSPVSRLKKTWGK--AKTAKFFI-LEHQMDPTGNFYNYRTALRGAAH 371
Cdd:smart00147  73 DRAELLSKFIQVAKHCRELNNFNSLMAIVSALSSSPISRLKKTWEKlpSKYKKLFEeLEELLSPERNYKNYREALSSCNL 152
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898583630  372 rsrtansnreRIVIPFFSLLIKDIYFLNEGCANRLPNGHVNFEKFVELARQVGEFMTWKQVECPFEEDRAILHYLHTAPI 451
Cdd:smart00147 153 ----------PPCIPFLGVLLKDLTFIDEGNPDFLENGLVNFEKRRQIAEILREIRQLQSQPYNLRPNRSDIQSLLQQLL 222
                          250       260
                   ....*....|....*....|
gi 1898583630  452 F---SEDGLYLASYESESPE 468
Cdd:smart00147 223 DhldEEEELYQLSLKIEPRV 242
RasGEF cd00155
Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of ...
216-463 1.09e-58

Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. Guanine-nucleotide-exchange factors (GEFs) positively regulate these GTP-binding proteins in response to a variety of signals. GEFs catalyze the dissociation of GDP from the inactive GTP-binding proteins. GTP can then bind and induce structural changes that allow interaction with effectors.


Pssm-ID: 238087 [Multi-domain]  Cd Length: 237  Bit Score: 193.62  E-value: 1.09e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898583630 216 CNDPYTLAQQLTHVELEHLRHIGPEEFVQA-FVQKDPLDGTQPcfsdqkkktsNLEAYVRWFNRLCYLVATEICMPAKKK 294
Cdd:cd00155     3 SLDPKELAEQLTLLDFELFRKIEPFELLGSlWSKKDKNIHLSP----------NLERFIERFNNLSNWVASEILLCTNPK 72
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898583630 295 QRAQVIEFFIDVARECFNIGNFNSLMAIISGMNMSPVSRLKKTWGK--AKTAKFF-ILEHQMDPTGNFYNYRTALRgaah 371
Cdd:cd00155    73 KRARLLSKFIQVAKHCRELNNFNSLMAIVSALSSSPISRLKKTWEVlsSKLKKLFeELEELVDPSRNFKNYRKLLK---- 148
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898583630 372 rsrtaNSNRERIVIPFFSLLIKDIYFLNEGCANRLPNGHVNFEKFVELARQVGEFMTWKQVECPFEEDRAILHYLHT--A 449
Cdd:cd00155   149 -----SVGPNPPCVPFLGVYLKDLTFLHEGNPDFLEGNLVNFEKRRKIAEILREIRQLQSNSYELNRDEDILAFLWKllE 223
                         250
                  ....*....|....
gi 1898583630 450 PIFSEDGLYLASYE 463
Cdd:cd00155   224 LILNEDELYELSLE 237
REM cd06224
Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also ...
53-171 1.42e-17

Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately N-terminal to the RasGef (Cdc25-like) domain. REM contacts the GTPase and is assumed to participate in the catalytic activity of the exchange factor. Proteins with the REM domain include Sos1 and Sos2, which relay signals from tyrosine-kinase mediated signalling to Ras, RasGRP1-4, RasGRF1,2, CNrasGEF, and RAP-specific nucleotide exchange factors, to name a few.


Pssm-ID: 100121  Cd Length: 122  Bit Score: 78.61  E-value: 1.42e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898583630  53 SLDTLIHNLVPTaDYYPEKAYVFTFLLSARLFIPPPELLSRLCELCIKQQQLDQSPLDT--AKVRKFGPKILQLLTEWTE 130
Cdd:cd06224     1 TLEALIEHLTST-FDMPDPSFVSTFLLTYRSFTTPTELLEKLIERYEIAPPENLEYNDWdkKKSKPIRLRVLNVLRTWVE 79
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1898583630 131 TFPSDF-RDEKMVGHFKDIIHRIAPCDEAYWKTLNQVLQKLS 171
Cdd:cd06224    80 NYPYDFfDDEELLELLEEFLNRLVQEGALLQELKKLLRKLLK 121
RasGEF_N pfam00618
RasGEF N-terminal motif; A subset of guanine nucleotide exchange factor for Ras-like small ...
49-142 2.32e-11

RasGEF N-terminal motif; A subset of guanine nucleotide exchange factor for Ras-like small GTPases appear to possess this motif/domain N-terminal to the RasGef (Cdc25-like) domain.


Pssm-ID: 459873  Cd Length: 104  Bit Score: 60.40  E-value: 2.32e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898583630  49 ITSASLDTLIHNLVPTaDYYPEKAYVFTFLLSARLFIPPPELLSRLCELCIKQQQLDQSPLDTAKVRKFGP---KILQLL 125
Cdd:pfam00618   2 VKAGTLEKLVEYLTST-RIMLDDSFLSTFLLTYRSFTTPAELLELLIERYNIPPPLDLSSDSYWISKKTLPiriRVLSVL 80
                          90
                  ....*....|....*..
gi 1898583630 126 TEWTETFPSDFRDEKMV 142
Cdd:pfam00618  81 RHWVENYFSDFNDDPVL 97
RasGEFN smart00229
Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif; A subset of guanine ...
45-139 9.56e-11

Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif; A subset of guanine nucleotide exchange factor for Ras-like small GTPases appear to possess this domain N-terminal to the RasGef (Cdc25-like) domain. The recent crystal structureof Sos shows that this domain is alpha-helical and plays a "purely structural role" (Nature 394, 337-343).


Pssm-ID: 214571  Cd Length: 127  Bit Score: 59.27  E-value: 9.56e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898583630   45 DGPPITSASLDTLIHNLVPTaDYYPEKAYVFTFLLSARLFIPPPELLSRLCEL--CIKQQQLDQSPLDTAKVRKfgpKIL 122
Cdd:smart00229   1 DGGLIKGGTLEALIEHLTEA-FDKADPSFVETFLLTYRSFITTQELLQLLLYRynAIPPESWVEEKVNPRRVKN---RVL 76
                           90
                   ....*....|....*..
gi 1898583630  123 QLLTEWTETFPSDFRDE 139
Cdd:smart00229  77 NILRTWVENYWEDFEDD 93
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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