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Conserved domains on  [gi|1958795120|ref|XP_038936974|]
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sortilin-related receptor isoform X1 [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
VPS10 smart00602
VPS10 domain;
124-753 0e+00

VPS10 domain;


:

Pssm-ID: 214740 [Multi-domain]  Cd Length: 612  Bit Score: 759.63  E-value: 0e+00
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958795120   124 SLALTRPKSSDVYVSYDYGKSFNKISEklNFGVGNssEAVISQFYHSPADNKRYIFvdaYARYLWITFDFGSTIHGFSIP 203
Cdd:smart00602    1 SLLLGSAEESSVYISEDYGKTWKKIDE--IEGVII--ETVISDFFNSSANKFKTIL---VKGYIFISSDEGKSFQKFTLP 73

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958795120   204 F-RAADLLLHSKASNLLLGFDSSHPNKQLWKSDDFGQTWIMIQEHVKS--FSWGIDP-YDQPNTIYIERHEPFGFSTVFR 279
Cdd:smart00602   74 FpPLPSLLYHPKHPDYVLAYSKDCNYKVLYVSKDFGKTWTEIQENVESceFSWGSMGvYDFPDLVHISVKENSGALTELV 153

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958795120   280 STDFFQSRENQEVILEEVRDFQLRDKYLFATKVvhlpgSQQQSSVQLWVSFGRKPMRAAQFVTKHPINE---YYIADASE 356
Cdd:smart00602  154 SSIDFFQRYDQSTIFLDIVGFLLTDEYLFVAVT-----DEDTTSRKLYVSNDRSTFAMAKFPKYHALGKqqaYTILDSDE 228

                           250       260       270       280       290       300       310       320
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958795120   357 DQVFVCVSHS--NNSTNLYISEAEGLKFSLSLENVLYYSPGgagsdtlvryfanepFADFHRVEGLQGVYIATLINGSms 434
Cdd:smart00602  229 DSVFLHVSENnqNDTGNLYISDSRGTKFSLSLENVNRYTGG---------------YIDFYKVEGLKGIYIANIVSKV-- 291

                           330       340       350       360       370       380       390       400
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958795120   435 EENMRSVITFDKGGTWEFLQAPAFTGYGEKINCELS--QGCSLHLAQRLSQLLNlqlrRMPILSKESAPGLIIATGSVGK 512
Cdd:smart00602  292 DKQLQTKITFDKGGDWSLLKPPDVDNEGKKFNCDLTslEKCSLHLHLRYSESPY----SGDIASSKSAPGIIIASGNVGD 367

                           410       420       430       440       450       460       470       480
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958795120   513 NLAS--KTNVYISSSAGARWREALPGPHYYTWGDHGGIIMAIAQGMETNELKYSTNEGETWKTFVFSEKPVFVYGLLTEP 590
Cdd:smart00602  368 GLASywEPSTFISSDGGLTWRLVFDGPHLYAYGDHGGIIVAIEYNSPTNELKYSTDEGKTWKTYTFTSTPVFVKGLLTEP 447

                           490       500       510       520       530       540       550       560
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958795120   591 GEKSTVFTIFGSNKESVHSWLILQVNATDALGVPCTENDYKLWSPSDERGN--ECLLGHKTVFKRRTPHATCFNGE-DFD 667
Cdd:smart00602  448 GGSTLVFTLFGFTKERGSSWSLYTIDFKDIFERQCEEDDYKTWNLDDKRGSrdGCLLGHKTIFKRRKPTSQCLVGKsDYD 527

                           570       580       590       600       610       620       630       640
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958795120   668 RPVVVSNCSCTREDYECDFGFkMSEDISLEVCVPDPEFSGKPYspPVPCPVGSSYRR---TRGYRKISGDTCSGGdVEAR 744
Cdd:smart00602  528 LSLVSSPCSCTREDFECDFGF-YRLSEGDSTCVPDPNLSGNPL--SDDCKKGKSYTEyvkSLGYRKIPGDKCKGG-VKLE 603


                    ....*....
gi 1958795120   745 LEGELVPCP 753
Cdd:smart00602  604 AEDIPHPCP 612
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1157-1192 2.05e-13

Low-density lipoprotein receptor domain class A;


:

Pssm-ID: 395011  Cd Length: 37  Bit Score: 65.35  E-value: 2.05e-13
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1958795120 1157 QCRSDEFNCSSGMCIRSSWVCDGDNDCRDWSDEANC 1192
Cdd:pfam00057    2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1373-1403 1.19e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 60.30  E-value: 1.19e-11
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1958795120 1373 QFHCENGRCIPNRWKCDRENDCGDWSDEKDC 1403
Cdd:cd00112      5 EFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1325-1359 1.45e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 60.30  E-value: 1.45e-11
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1958795120 1325 CDEFGFQCQNGVCISLIWKCDGMDDCGDYSDEANC 1359
Cdd:cd00112      1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1198-1230 1.88e-11

Low-density lipoprotein receptor domain class A;


:

Pssm-ID: 395011  Cd Length: 37  Bit Score: 59.95  E-value: 1.88e-11
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1958795120 1198 TCEASNFQCHNGHCIPQRWACDGDADCQDGSDE 1230
Cdd:pfam00057    2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1240-1271 7.83e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 57.99  E-value: 7.83e-11
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1958795120 1240 NGFHCPNGTCIPSSKHCDGLRDCPDGSDEQHC 1271
Cdd:cd00112      4 NEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1419-1453 1.05e-10

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 57.60  E-value: 1.05e-10
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1958795120 1419 CLPNYFRCSSGACVMGTWVCDGYRDCADGSDEEAC 1453
Cdd:cd00112      1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1078-1112 1.16e-10

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 57.60  E-value: 1.16e-10
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1958795120 1078 CLRNQYHCSNGNCINSIWWCDFDNDCGDMSDERNC 1112
Cdd:cd00112      1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 824-866 3.95e-10

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 56.46  E-value: 3.95e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1958795120   824 EVIINSGLETVEALAFEPLSQLLYWVDAGFKKIEVANPDGDFR 866
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 913-953 8.96e-09

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 52.60  E-value: 8.96e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1958795120   913 YRLVSEDVKWPNGISVD--GHWIYWTDAYLDCIERITFSGQQR 953
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDwiEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1117-1153 1.40e-08

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 51.82  E-value: 1.40e-08
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1958795120 1117 CDADtQFRCQeSGTCIPLSYKCDLEDDCGDNSDESHC 1153
Cdd:cd00112      1 CPPN-EFRCA-NGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1471-1506 1.10e-07

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 49.13  E-value: 1.10e-07
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1958795120 1471 CDRFEFECRQpKKCIPNWKRCDGHQDCQDGQDEANC 1506
Cdd:cd00112      1 CPPNEFRCAN-GRCIPSSWVCDGEDDCGDGSDEENC 35
Ldl_recept_b super family cl44468
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 890-929 4.41e-07

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


The actual alignment was detected with superfamily member pfam00058:

Pssm-ID: 459654  Cd Length: 42  Bit Score: 47.54  E-value: 4.41e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1958795120  890 MFWTDWGdLKPGIYRSNMDGSAAYRLVSEDVKWPNGISVD 929
Cdd:pfam00058    3 LYWTDSS-LRASISSADLNGSDRKTLFTDDLQHPNAIAVD 41
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 868-910 2.60e-05

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 42.59  E-value: 2.60e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1958795120   868 TIVNSSvLDRPRALVLVPQEGVMFWTDWGdlKPGIYRSNMDGS 910
Cdd:smart00135    2 TLLSSG-LGHPNGLAVDWIEGRLYWTDWG--LDVIEVANLDGT 41
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 780-821 1.04e-04

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 41.05  E-value: 1.04e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 1958795120   780 EQLPLSGLRAAVALDFDYEHNCLYWSDLALDTIQRLCLNGST 821
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTN 42
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1281-1308 2.55e-04

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


:

Pssm-ID: 197566  Cd Length: 33  Bit Score: 39.54  E-value: 2.55e-04
                            10        20
                    ....*....|....*....|....*...
gi 1958795120  1281 FVCKNRQqCLFHSMVCDGIIQCRDGSDE 1308
Cdd:smart00192    7 FQCDNGR-CIPSSWVCDGVDDCGDGSDE 33
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 953-987 4.04e-03

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 36.43  E-value: 4.04e-03
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 1958795120   953 RSVILDNLPHPYAIAV--FKNEIYWDDWSQLSIFRAS 987
Cdd:smart00135    1 RTLLSSGLGHPNGLAVdwIEGRLYWTDWGLDVIEVAN 37
 
Name Accession Description Interval E-value
VPS10 smart00602
VPS10 domain;
124-753 0e+00

VPS10 domain;


Pssm-ID: 214740 [Multi-domain]  Cd Length: 612  Bit Score: 759.63  E-value: 0e+00
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958795120   124 SLALTRPKSSDVYVSYDYGKSFNKISEklNFGVGNssEAVISQFYHSPADNKRYIFvdaYARYLWITFDFGSTIHGFSIP 203
Cdd:smart00602    1 SLLLGSAEESSVYISEDYGKTWKKIDE--IEGVII--ETVISDFFNSSANKFKTIL---VKGYIFISSDEGKSFQKFTLP 73

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958795120   204 F-RAADLLLHSKASNLLLGFDSSHPNKQLWKSDDFGQTWIMIQEHVKS--FSWGIDP-YDQPNTIYIERHEPFGFSTVFR 279
Cdd:smart00602   74 FpPLPSLLYHPKHPDYVLAYSKDCNYKVLYVSKDFGKTWTEIQENVESceFSWGSMGvYDFPDLVHISVKENSGALTELV 153

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958795120   280 STDFFQSRENQEVILEEVRDFQLRDKYLFATKVvhlpgSQQQSSVQLWVSFGRKPMRAAQFVTKHPINE---YYIADASE 356
Cdd:smart00602  154 SSIDFFQRYDQSTIFLDIVGFLLTDEYLFVAVT-----DEDTTSRKLYVSNDRSTFAMAKFPKYHALGKqqaYTILDSDE 228

                           250       260       270       280       290       300       310       320
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958795120   357 DQVFVCVSHS--NNSTNLYISEAEGLKFSLSLENVLYYSPGgagsdtlvryfanepFADFHRVEGLQGVYIATLINGSms 434
Cdd:smart00602  229 DSVFLHVSENnqNDTGNLYISDSRGTKFSLSLENVNRYTGG---------------YIDFYKVEGLKGIYIANIVSKV-- 291

                           330       340       350       360       370       380       390       400
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958795120   435 EENMRSVITFDKGGTWEFLQAPAFTGYGEKINCELS--QGCSLHLAQRLSQLLNlqlrRMPILSKESAPGLIIATGSVGK 512
Cdd:smart00602  292 DKQLQTKITFDKGGDWSLLKPPDVDNEGKKFNCDLTslEKCSLHLHLRYSESPY----SGDIASSKSAPGIIIASGNVGD 367

                           410       420       430       440       450       460       470       480
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958795120   513 NLAS--KTNVYISSSAGARWREALPGPHYYTWGDHGGIIMAIAQGMETNELKYSTNEGETWKTFVFSEKPVFVYGLLTEP 590
Cdd:smart00602  368 GLASywEPSTFISSDGGLTWRLVFDGPHLYAYGDHGGIIVAIEYNSPTNELKYSTDEGKTWKTYTFTSTPVFVKGLLTEP 447

                           490       500       510       520       530       540       550       560
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958795120   591 GEKSTVFTIFGSNKESVHSWLILQVNATDALGVPCTENDYKLWSPSDERGN--ECLLGHKTVFKRRTPHATCFNGE-DFD 667
Cdd:smart00602  448 GGSTLVFTLFGFTKERGSSWSLYTIDFKDIFERQCEEDDYKTWNLDDKRGSrdGCLLGHKTIFKRRKPTSQCLVGKsDYD 527

                           570       580       590       600       610       620       630       640
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958795120   668 RPVVVSNCSCTREDYECDFGFkMSEDISLEVCVPDPEFSGKPYspPVPCPVGSSYRR---TRGYRKISGDTCSGGdVEAR 744
Cdd:smart00602  528 LSLVSSPCSCTREDFECDFGF-YRLSEGDSTCVPDPNLSGNPL--SDDCKKGKSYTEyvkSLGYRKIPGDKCKGG-VKLE 603


                    ....*....
gi 1958795120   745 LEGELVPCP 753
Cdd:smart00602  604 AEDIPHPCP 612
Sortilin-Vps10 pfam15902
Sortilin, neurotensin receptor 3,; Sortilin, also known in mammals as neurotensin receptor-3, ...
 133-586 6.85e-137

Sortilin, neurotensin receptor 3,; Sortilin, also known in mammals as neurotensin receptor-3, is the archetypical member of a Vps10-domain (Vps10-D) that binds neurotrophic factors and neuropeptides. This domain constitutes the entire luminal part of Sortilin and is activated in the trans-Golgi network by enzymatic propeptide cleavage. The structure of the domain has been determined as a ten-bladed propeller, with up to 9 BNR or beta-hairpin turns in it. The mature receptor binds various ligands, including its own propeptide (Sort-pro), neurotensin, the pro-forms of nerve growth factor-beta (NGF)6 and brain-derived neurotrophic factor (BDNF)7, lipoprotein lipase (LpL), apo lipoprotein AV14 and the receptor-associated protein (RAP)1.


Pssm-ID: 464929 [Multi-domain]  Cd Length: 444  Bit Score: 429.70  E-value: 6.85e-137
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958795120  133 SDVYVSYDYGKSFNKISEKLNfgvgnssEAVISQFYHSPADNKRYIFVDAyARYLWITFDFGSTIHGFSIPFRAA----D 208
Cdd:pfam15902    1 SEVYRSHDYGKTWKKVKDVPD-------GEAILAIYPHPYDNDRAYLLTD-GKKHYYTTDRGKTFRSFKLPFPPNlfgpP 72

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958795120  209 LLLHSKASNLLLGFD----SSHPNKQLWKSDDFGQTWIMIQEHVKSFSWGIDPYDQPNTIYIERHEP------FGFSTVF 278
Cdd:pfam15902   73 LSFHPKDPDWLIWYGgkcfSGDCHSVAYYSTDGGKSWKLLLEYVRRCEWAVSSKADENLIFCEVYENesgnadDVKLRLV 152

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958795120  279 RSTDFFQSREnqEVILEEVRDFQLRDKYLFATKVvhlpgSQQQSSVQLWVSFGRKPMRAAQFVTKHPINEYYIADASEDQ 358
Cdd:pfam15902  153 SSDDFFKSDK--VLFDDGVVGFAVVGEFIVVAVK-----SENTSELALYVSYDGKTFARAQFPHVLEQQAYTVLESSTHS 225

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958795120  359 VFVCVSHSNNS--TNLYISEAEGLKFSLSLENVlyyspggagsdtlvrYFANEPFADFHRVEGLQGVYIA-TLIN----G 431
Cdd:pfam15902  226 IFLHVTTSSDNpyGSLYKSNSNGTYFVLSLENV---------------NRNERGYVDFEKVAGLEGVYLAnVVSNaeevG 290

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958795120  432 SMSEENMRSVITFDKGGTWEFLQAPAFTGYGeKINCELSQGCSLHLAQRLSQLLNlqlRRMPILSKESAPGLIIATGSVG 511
Cdd:pfam15902  291 KGADKKLKTKITFNDGGTWQPLKPPDKDSEY-KCSGKGLEKCSLHLHGYTERLVN---IGRDTFSSPSAPGLIMGVGNVG 366

                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958795120  512 KNLASKT--NVYISSSAGARWREALPGPHYYTWGDHGGIIMAIAQ-GMETNELKYSTNEGETWKTFVFSEKPVFVYGL 586
Cdd:pfam15902  367 DSLGPYEdaDTFISRDGGITWKEVLKGPHKWEFGDQGSIIVAVKDeGDPTDEISYSLDEGKTWETYKFADEKIRVLDL 444
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1157-1192 2.05e-13

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 65.35  E-value: 2.05e-13
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1958795120 1157 QCRSDEFNCSSGMCIRSSWVCDGDNDCRDWSDEANC 1192
Cdd:pfam00057    2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1158-1192 3.51e-12

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 61.84  E-value: 3.51e-12
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1958795120 1158 CRSDEFNCSSGMCIRSSWVCDGDNDCRDWSDEANC 1192
Cdd:cd00112      1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1373-1403 1.19e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 60.30  E-value: 1.19e-11
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1958795120 1373 QFHCENGRCIPNRWKCDRENDCGDWSDEKDC 1403
Cdd:cd00112      5 EFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1325-1359 1.45e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 60.30  E-value: 1.45e-11
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1958795120 1325 CDEFGFQCQNGVCISLIWKCDGMDDCGDYSDEANC 1359
Cdd:cd00112      1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1198-1230 1.88e-11

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 59.95  E-value: 1.88e-11
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1958795120 1198 TCEASNFQCHNGHCIPQRWACDGDADCQDGSDE 1230
Cdd:pfam00057    2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1198-1230 2.41e-11

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 59.57  E-value: 2.41e-11
                            10        20        30
                    ....*....|....*....|....*....|...
gi 1958795120  1198 TCEASNFQCHNGHCIPQRWACDGDADCQDGSDE 1230
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1199-1231 5.79e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 58.37  E-value: 5.79e-11
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1958795120 1199 CEASNFQCHNGHCIPQRWACDGDADCQDGSDED 1231
Cdd:cd00112      1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1240-1271 7.83e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 57.99  E-value: 7.83e-11
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1958795120 1240 NGFHCPNGTCIPSSKHCDGLRDCPDGSDEQHC 1271
Cdd:cd00112      4 NEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1419-1453 1.05e-10

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 57.60  E-value: 1.05e-10
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1958795120 1419 CLPNYFRCSSGACVMGTWVCDGYRDCADGSDEEAC 1453
Cdd:cd00112      1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1078-1112 1.16e-10

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 57.60  E-value: 1.16e-10
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1958795120 1078 CLRNQYHCSNGNCINSIWWCDFDNDCGDMSDERNC 1112
Cdd:cd00112      1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1373-1403 1.17e-10

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 57.64  E-value: 1.17e-10
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1958795120 1373 QFHCENGRCIPNRWKCDRENDCGDWSDEKDC 1403
Cdd:pfam00057    7 EFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1157-1189 1.59e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 57.26  E-value: 1.59e-10
                            10        20        30
                    ....*....|....*....|....*....|...
gi 1958795120  1157 QCRSDEFNCSSGMCIRSSWVCDGDNDCRDWSDE 1189
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 824-866 3.95e-10

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 56.46  E-value: 3.95e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1958795120   824 EVIINSGLETVEALAFEPLSQLLYWVDAGFKKIEVANPDGDFR 866
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1325-1359 7.00e-10

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 55.33  E-value: 7.00e-10
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1958795120 1325 CDEFGFQCQNGVCISLIWKCDGMDDCGDYSDEANC 1359
Cdd:pfam00057    3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1324-1356 8.78e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 54.95  E-value: 8.78e-10
                            10        20        30
                    ....*....|....*....|....*....|...
gi 1958795120  1324 ECDEFGFQCQNGVCISLIWKCDGMDDCGDYSDE 1356
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1373-1400 9.88e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 54.95  E-value: 9.88e-10
                            10        20
                    ....*....|....*....|....*...
gi 1958795120  1373 QFHCENGRCIPNRWKCDRENDCGDWSDE 1400
Cdd:smart00192    6 EFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1418-1450 1.24e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 54.56  E-value: 1.24e-09
                            10        20        30
                    ....*....|....*....|....*....|...
gi 1958795120  1418 TCLPNYFRCSSGACVMGTWVCDGYRDCADGSDE 1450
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1240-1271 1.30e-09

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 54.56  E-value: 1.30e-09
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1958795120 1240 NGFHCPNGTCIPSSKHCDGLRDCPDGSDEQHC 1271
Cdd:pfam00057    6 NEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1239-1268 2.68e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 53.79  E-value: 2.68e-09
                            10        20        30
                    ....*....|....*....|....*....|
gi 1958795120  1239 CNGFHCPNGTCIPSSKHCDGLRDCPDGSDE 1268
Cdd:smart00192    4 PGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1417-1453 3.52e-09

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 53.41  E-value: 3.52e-09
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1958795120 1417 STCLPNYFRCSSGACVMGTWVCDGYRDCADGSDEEAC 1453
Cdd:pfam00057    1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1077-1109 3.56e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 53.41  E-value: 3.56e-09
                            10        20        30
                    ....*....|....*....|....*....|...
gi 1958795120  1077 TCLRNQYHCSNGNCINSIWWCDFDNDCGDMSDE 1109
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 913-953 8.96e-09

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 52.60  E-value: 8.96e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1958795120   913 YRLVSEDVKWPNGISVD--GHWIYWTDAYLDCIERITFSGQQR 953
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDwiEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1117-1153 1.40e-08

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 51.82  E-value: 1.40e-08
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1958795120 1117 CDADtQFRCQeSGTCIPLSYKCDLEDDCGDNSDESHC 1153
Cdd:cd00112      1 CPPN-EFRCA-NGRCIPSSWVCDGEDDCGDGSDEENC 35
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1077-1112 1.44e-08

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 51.87  E-value: 1.44e-08
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1958795120 1077 TCLRNQYHCSNGNCINSIWWCDFDNDCGDMSDERNC 1112
Cdd:pfam00057    2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1471-1506 1.10e-07

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 49.13  E-value: 1.10e-07
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1958795120 1471 CDRFEFECRQpKKCIPNWKRCDGHQDCQDGQDEANC 1506
Cdd:cd00112      1 CPPNEFRCAN-GRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1117-1150 3.34e-07

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 47.63  E-value: 3.34e-07
                            10        20        30
                    ....*....|....*....|....*....|....
gi 1958795120  1117 CDADtQFRCQeSGTCIPLSYKCDLEDDCGDNSDE 1150
Cdd:smart00192    2 CPPG-EFQCD-NGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 890-929 4.41e-07

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 47.54  E-value: 4.41e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1958795120  890 MFWTDWGdLKPGIYRSNMDGSAAYRLVSEDVKWPNGISVD 929
Cdd:pfam00058    3 LYWTDSS-LRASISSADLNGSDRKTLFTDDLQHPNAIAVD 41
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1470-1506 8.46e-07

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 46.86  E-value: 8.46e-07
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1958795120 1470 QCDRFEFECRQpKKCIPNWKRCDGHQDCQDGQDEANC 1506
Cdd:pfam00057    2 TCSPNEFQCGS-GECIPRSWVCDGDPDCGDGSDEENC 37
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1470-1503 2.64e-06

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 45.32  E-value: 2.64e-06
                            10        20        30
                    ....*....|....*....|....*....|....
gi 1958795120  1470 QCDRFEFECRqPKKCIPNWKRCDGHQDCQDGQDE 1503
Cdd:smart00192    1 TCPPGEFQCD-NGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1117-1153 5.40e-06

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 44.55  E-value: 5.40e-06
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1958795120 1117 CDADtQFRCQeSGTCIPLSYKCDLEDDCGDNSDESHC 1153
Cdd:pfam00057    3 CSPN-EFQCG-SGECIPRSWVCDGDPDCGDGSDEENC 37
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 868-910 2.60e-05

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 42.59  E-value: 2.60e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1958795120   868 TIVNSSvLDRPRALVLVPQEGVMFWTDWGdlKPGIYRSNMDGS 910
Cdd:smart00135    2 TLLSSG-LGHPNGLAVDWIEGRLYWTDWG--LDVIEVANLDGT 41
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 780-821 1.04e-04

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 41.05  E-value: 1.04e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 1958795120   780 EQLPLSGLRAAVALDFDYEHNCLYWSDLALDTIQRLCLNGST 821
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTN 42
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1281-1308 2.55e-04

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 39.54  E-value: 2.55e-04
                            10        20
                    ....*....|....*....|....*...
gi 1958795120  1281 FVCKNRQqCLFHSMVCDGIIQCRDGSDE 1308
Cdd:smart00192    7 FQCDNGR-CIPSSWVCDGVDDCGDGSDE 33
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 798-937 3.75e-04

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 44.11  E-value: 3.75e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958795120  798 EHNCLYWSDLALDTIQRLCLNGSTGQEVIINSGLetVEALAFEPLSQL--------LYWVDAGFKKIEVANPDGDFRLTI 869
Cdd:COG3386     17 PDGRLYWVDIPGGRIHRYDPDGGAVEVFAEPSGR--PNGLAFDPDGRLlvadhgrgLVRFDPADGEVTVLADEYGKPLNR 94

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958795120  870 VNSSVLDRpralvlvpqEGVMFWTDWGDLKP--GIYRSNMDGSAayRLVSEDVKWPNGI--SVDGHWIYWTD 937
Cdd:COG3386     95 PNDGVVDP---------DGRLYFTDMGEYLPtgALYRVDPDGSL--RVLADGLTFPNGIafSPDGRTLYVAD 155
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1281-1309 7.10e-04

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 38.34  E-value: 7.10e-04
                           10        20
                   ....*....|....*....|....*....
gi 1958795120 1281 FVCKNRQqCLFHSMVCDGIIQCRDGSDED 1309
Cdd:cd00112      6 FRCANGR-CIPSSWVCDGEDDCGDGSDEE 33
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 933-969 1.94e-03

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 37.52  E-value: 1.94e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1958795120  933 IYWTDAYLDC-IERITFSGQQRSVIL-DNLPHPYAIAVF 969
Cdd:pfam00058    3 LYWTDSSLRAsISSADLNGSDRKTLFtDDLQHPNAIAVD 41
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 953-987 4.04e-03

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 36.43  E-value: 4.04e-03
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 1958795120   953 RSVILDNLPHPYAIAV--FKNEIYWDDWSQLSIFRAS 987
Cdd:smart00135    1 RTLLSSGLGHPNGLAVdwIEGRLYWTDWGLDVIEVAN 37
 
Name Accession Description Interval E-value
VPS10 smart00602
VPS10 domain;
124-753 0e+00

VPS10 domain;


Pssm-ID: 214740 [Multi-domain]  Cd Length: 612  Bit Score: 759.63  E-value: 0e+00
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958795120   124 SLALTRPKSSDVYVSYDYGKSFNKISEklNFGVGNssEAVISQFYHSPADNKRYIFvdaYARYLWITFDFGSTIHGFSIP 203
Cdd:smart00602    1 SLLLGSAEESSVYISEDYGKTWKKIDE--IEGVII--ETVISDFFNSSANKFKTIL---VKGYIFISSDEGKSFQKFTLP 73

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958795120   204 F-RAADLLLHSKASNLLLGFDSSHPNKQLWKSDDFGQTWIMIQEHVKS--FSWGIDP-YDQPNTIYIERHEPFGFSTVFR 279
Cdd:smart00602   74 FpPLPSLLYHPKHPDYVLAYSKDCNYKVLYVSKDFGKTWTEIQENVESceFSWGSMGvYDFPDLVHISVKENSGALTELV 153

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958795120   280 STDFFQSRENQEVILEEVRDFQLRDKYLFATKVvhlpgSQQQSSVQLWVSFGRKPMRAAQFVTKHPINE---YYIADASE 356
Cdd:smart00602  154 SSIDFFQRYDQSTIFLDIVGFLLTDEYLFVAVT-----DEDTTSRKLYVSNDRSTFAMAKFPKYHALGKqqaYTILDSDE 228

                           250       260       270       280       290       300       310       320
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958795120   357 DQVFVCVSHS--NNSTNLYISEAEGLKFSLSLENVLYYSPGgagsdtlvryfanepFADFHRVEGLQGVYIATLINGSms 434
Cdd:smart00602  229 DSVFLHVSENnqNDTGNLYISDSRGTKFSLSLENVNRYTGG---------------YIDFYKVEGLKGIYIANIVSKV-- 291

                           330       340       350       360       370       380       390       400
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958795120   435 EENMRSVITFDKGGTWEFLQAPAFTGYGEKINCELS--QGCSLHLAQRLSQLLNlqlrRMPILSKESAPGLIIATGSVGK 512
Cdd:smart00602  292 DKQLQTKITFDKGGDWSLLKPPDVDNEGKKFNCDLTslEKCSLHLHLRYSESPY----SGDIASSKSAPGIIIASGNVGD 367

                           410       420       430       440       450       460       470       480
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958795120   513 NLAS--KTNVYISSSAGARWREALPGPHYYTWGDHGGIIMAIAQGMETNELKYSTNEGETWKTFVFSEKPVFVYGLLTEP 590
Cdd:smart00602  368 GLASywEPSTFISSDGGLTWRLVFDGPHLYAYGDHGGIIVAIEYNSPTNELKYSTDEGKTWKTYTFTSTPVFVKGLLTEP 447

                           490       500       510       520       530       540       550       560
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958795120   591 GEKSTVFTIFGSNKESVHSWLILQVNATDALGVPCTENDYKLWSPSDERGN--ECLLGHKTVFKRRTPHATCFNGE-DFD 667
Cdd:smart00602  448 GGSTLVFTLFGFTKERGSSWSLYTIDFKDIFERQCEEDDYKTWNLDDKRGSrdGCLLGHKTIFKRRKPTSQCLVGKsDYD 527

                           570       580       590       600       610       620       630       640
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958795120   668 RPVVVSNCSCTREDYECDFGFkMSEDISLEVCVPDPEFSGKPYspPVPCPVGSSYRR---TRGYRKISGDTCSGGdVEAR 744
Cdd:smart00602  528 LSLVSSPCSCTREDFECDFGF-YRLSEGDSTCVPDPNLSGNPL--SDDCKKGKSYTEyvkSLGYRKIPGDKCKGG-VKLE 603


                    ....*....
gi 1958795120   745 LEGELVPCP 753
Cdd:smart00602  604 AEDIPHPCP 612
Sortilin-Vps10 pfam15902
Sortilin, neurotensin receptor 3,; Sortilin, also known in mammals as neurotensin receptor-3, ...
 133-586 6.85e-137

Sortilin, neurotensin receptor 3,; Sortilin, also known in mammals as neurotensin receptor-3, is the archetypical member of a Vps10-domain (Vps10-D) that binds neurotrophic factors and neuropeptides. This domain constitutes the entire luminal part of Sortilin and is activated in the trans-Golgi network by enzymatic propeptide cleavage. The structure of the domain has been determined as a ten-bladed propeller, with up to 9 BNR or beta-hairpin turns in it. The mature receptor binds various ligands, including its own propeptide (Sort-pro), neurotensin, the pro-forms of nerve growth factor-beta (NGF)6 and brain-derived neurotrophic factor (BDNF)7, lipoprotein lipase (LpL), apo lipoprotein AV14 and the receptor-associated protein (RAP)1.


Pssm-ID: 464929 [Multi-domain]  Cd Length: 444  Bit Score: 429.70  E-value: 6.85e-137
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958795120  133 SDVYVSYDYGKSFNKISEKLNfgvgnssEAVISQFYHSPADNKRYIFVDAyARYLWITFDFGSTIHGFSIPFRAA----D 208
Cdd:pfam15902    1 SEVYRSHDYGKTWKKVKDVPD-------GEAILAIYPHPYDNDRAYLLTD-GKKHYYTTDRGKTFRSFKLPFPPNlfgpP 72

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958795120  209 LLLHSKASNLLLGFD----SSHPNKQLWKSDDFGQTWIMIQEHVKSFSWGIDPYDQPNTIYIERHEP------FGFSTVF 278
Cdd:pfam15902   73 LSFHPKDPDWLIWYGgkcfSGDCHSVAYYSTDGGKSWKLLLEYVRRCEWAVSSKADENLIFCEVYENesgnadDVKLRLV 152

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958795120  279 RSTDFFQSREnqEVILEEVRDFQLRDKYLFATKVvhlpgSQQQSSVQLWVSFGRKPMRAAQFVTKHPINEYYIADASEDQ 358
Cdd:pfam15902  153 SSDDFFKSDK--VLFDDGVVGFAVVGEFIVVAVK-----SENTSELALYVSYDGKTFARAQFPHVLEQQAYTVLESSTHS 225

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958795120  359 VFVCVSHSNNS--TNLYISEAEGLKFSLSLENVlyyspggagsdtlvrYFANEPFADFHRVEGLQGVYIA-TLIN----G 431
Cdd:pfam15902  226 IFLHVTTSSDNpyGSLYKSNSNGTYFVLSLENV---------------NRNERGYVDFEKVAGLEGVYLAnVVSNaeevG 290

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958795120  432 SMSEENMRSVITFDKGGTWEFLQAPAFTGYGeKINCELSQGCSLHLAQRLSQLLNlqlRRMPILSKESAPGLIIATGSVG 511
Cdd:pfam15902  291 KGADKKLKTKITFNDGGTWQPLKPPDKDSEY-KCSGKGLEKCSLHLHGYTERLVN---IGRDTFSSPSAPGLIMGVGNVG 366

                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958795120  512 KNLASKT--NVYISSSAGARWREALPGPHYYTWGDHGGIIMAIAQ-GMETNELKYSTNEGETWKTFVFSEKPVFVYGL 586
Cdd:pfam15902  367 DSLGPYEdaDTFISRDGGITWKEVLKGPHKWEFGDQGSIIVAVKDeGDPTDEISYSLDEGKTWETYKFADEKIRVLDL 444
Sortilin_C pfam15901
Sortilin, neurotensin receptor 3, C-terminal; Sortilin_C is the C-terminal cytoplasmic tail of ...
 588-752 2.23e-56

Sortilin, neurotensin receptor 3, C-terminal; Sortilin_C is the C-terminal cytoplasmic tail of sortilin, a Vps10p domain-containing family of proteins. Most sortilin is expressed within intracellular compartments, where it chaperones diverse ligands, including proBDNF and acid hydrolases. The sortilin cytoplasmic tail is homologous to mannose 6-phosphate receptor and is required for the intracellular trafficking of cargo proteins via interactions with distinct adaptor molecules. In addition to mediating lysosomal targeting of specific acid hydrolases, the sortilin cytoplasmic tail also directs trafficking of BDNF to the secretory pathway in neurons, where it can be released in response to depolarization to modulate cell survival and synaptic plasticity.


Pssm-ID: 464928 [Multi-domain]  Cd Length: 164  Bit Score: 192.92  E-value: 2.23e-56
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958795120  588 TEPGEKSTVFTIFGSNKESVHSWLIL-QVNATDALGVPCTENDYKLWSPS-DERGNECLLGHKTVFKRRTPHATCFNGED 665
Cdd:pfam15901    1 TEPDDTSLKFLLFGSSSSSRSDWEVVyTIDFSGLFDRKCTDDDYELWSPRhDQDGPKCLLGHKQKYRRRKPDADCFNGKD 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958795120  666 FDRPVVVSNCSCTREDYECDFGFKMSEDISleVCVPDPEFSgKPYSPPVPCPVGSSYRRTRGYRKISGDTCSGGDVEARL 745
Cdd:pfam15901   81 FKDPKIEENCECTREDFECDYGFERSANDG--KCVLVPGLL-PPDGPKEDCKPGTYYLGSSGYRKIPGNTCEGGLELDKD 157


                   ....*..
gi 1958795120  746 EGELVPC 752
Cdd:pfam15901  158 EPVEHPC 164
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1157-1192 2.05e-13

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 65.35  E-value: 2.05e-13
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1958795120 1157 QCRSDEFNCSSGMCIRSSWVCDGDNDCRDWSDEANC 1192
Cdd:pfam00057    2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1158-1192 3.51e-12

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 61.84  E-value: 3.51e-12
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1958795120 1158 CRSDEFNCSSGMCIRSSWVCDGDNDCRDWSDEANC 1192
Cdd:cd00112      1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1373-1403 1.19e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 60.30  E-value: 1.19e-11
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1958795120 1373 QFHCENGRCIPNRWKCDRENDCGDWSDEKDC 1403
Cdd:cd00112      5 EFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1325-1359 1.45e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 60.30  E-value: 1.45e-11
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1958795120 1325 CDEFGFQCQNGVCISLIWKCDGMDDCGDYSDEANC 1359
Cdd:cd00112      1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1198-1230 1.88e-11

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 59.95  E-value: 1.88e-11
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1958795120 1198 TCEASNFQCHNGHCIPQRWACDGDADCQDGSDE 1230
Cdd:pfam00057    2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1198-1230 2.41e-11

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 59.57  E-value: 2.41e-11
                            10        20        30
                    ....*....|....*....|....*....|...
gi 1958795120  1198 TCEASNFQCHNGHCIPQRWACDGDADCQDGSDE 1230
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1199-1231 5.79e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 58.37  E-value: 5.79e-11
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1958795120 1199 CEASNFQCHNGHCIPQRWACDGDADCQDGSDED 1231
Cdd:cd00112      1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1240-1271 7.83e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 57.99  E-value: 7.83e-11
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1958795120 1240 NGFHCPNGTCIPSSKHCDGLRDCPDGSDEQHC 1271
Cdd:cd00112      4 NEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1419-1453 1.05e-10

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 57.60  E-value: 1.05e-10
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1958795120 1419 CLPNYFRCSSGACVMGTWVCDGYRDCADGSDEEAC 1453
Cdd:cd00112      1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1078-1112 1.16e-10

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 57.60  E-value: 1.16e-10
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1958795120 1078 CLRNQYHCSNGNCINSIWWCDFDNDCGDMSDERNC 1112
Cdd:cd00112      1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1373-1403 1.17e-10

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 57.64  E-value: 1.17e-10
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1958795120 1373 QFHCENGRCIPNRWKCDRENDCGDWSDEKDC 1403
Cdd:pfam00057    7 EFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1157-1189 1.59e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 57.26  E-value: 1.59e-10
                            10        20        30
                    ....*....|....*....|....*....|...
gi 1958795120  1157 QCRSDEFNCSSGMCIRSSWVCDGDNDCRDWSDE 1189
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 824-866 3.95e-10

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 56.46  E-value: 3.95e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1958795120   824 EVIINSGLETVEALAFEPLSQLLYWVDAGFKKIEVANPDGDFR 866
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1325-1359 7.00e-10

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 55.33  E-value: 7.00e-10
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1958795120 1325 CDEFGFQCQNGVCISLIWKCDGMDDCGDYSDEANC 1359
Cdd:pfam00057    3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1324-1356 8.78e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 54.95  E-value: 8.78e-10
                            10        20        30
                    ....*....|....*....|....*....|...
gi 1958795120  1324 ECDEFGFQCQNGVCISLIWKCDGMDDCGDYSDE 1356
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1373-1400 9.88e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 54.95  E-value: 9.88e-10
                            10        20
                    ....*....|....*....|....*...
gi 1958795120  1373 QFHCENGRCIPNRWKCDRENDCGDWSDE 1400
Cdd:smart00192    6 EFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1418-1450 1.24e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 54.56  E-value: 1.24e-09
                            10        20        30
                    ....*....|....*....|....*....|...
gi 1958795120  1418 TCLPNYFRCSSGACVMGTWVCDGYRDCADGSDE 1450
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1240-1271 1.30e-09

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 54.56  E-value: 1.30e-09
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1958795120 1240 NGFHCPNGTCIPSSKHCDGLRDCPDGSDEQHC 1271
Cdd:pfam00057    6 NEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1239-1268 2.68e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 53.79  E-value: 2.68e-09
                            10        20        30
                    ....*....|....*....|....*....|
gi 1958795120  1239 CNGFHCPNGTCIPSSKHCDGLRDCPDGSDE 1268
Cdd:smart00192    4 PGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1417-1453 3.52e-09

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 53.41  E-value: 3.52e-09
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1958795120 1417 STCLPNYFRCSSGACVMGTWVCDGYRDCADGSDEEAC 1453
Cdd:pfam00057    1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1077-1109 3.56e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 53.41  E-value: 3.56e-09
                            10        20        30
                    ....*....|....*....|....*....|...
gi 1958795120  1077 TCLRNQYHCSNGNCINSIWWCDFDNDCGDMSDE 1109
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 913-953 8.96e-09

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 52.60  E-value: 8.96e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1958795120   913 YRLVSEDVKWPNGISVD--GHWIYWTDAYLDCIERITFSGQQR 953
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDwiEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1117-1153 1.40e-08

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 51.82  E-value: 1.40e-08
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1958795120 1117 CDADtQFRCQeSGTCIPLSYKCDLEDDCGDNSDESHC 1153
Cdd:cd00112      1 CPPN-EFRCA-NGRCIPSSWVCDGEDDCGDGSDEENC 35
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1077-1112 1.44e-08

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 51.87  E-value: 1.44e-08
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1958795120 1077 TCLRNQYHCSNGNCINSIWWCDFDNDCGDMSDERNC 1112
Cdd:pfam00057    2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1471-1506 1.10e-07

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 49.13  E-value: 1.10e-07
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1958795120 1471 CDRFEFECRQpKKCIPNWKRCDGHQDCQDGQDEANC 1506
Cdd:cd00112      1 CPPNEFRCAN-GRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1117-1150 3.34e-07

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 47.63  E-value: 3.34e-07
                            10        20        30
                    ....*....|....*....|....*....|....
gi 1958795120  1117 CDADtQFRCQeSGTCIPLSYKCDLEDDCGDNSDE 1150
Cdd:smart00192    2 CPPG-EFQCD-NGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 890-929 4.41e-07

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 47.54  E-value: 4.41e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1958795120  890 MFWTDWGdLKPGIYRSNMDGSAAYRLVSEDVKWPNGISVD 929
Cdd:pfam00058    3 LYWTDSS-LRASISSADLNGSDRKTLFTDDLQHPNAIAVD 41
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1470-1506 8.46e-07

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 46.86  E-value: 8.46e-07
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1958795120 1470 QCDRFEFECRQpKKCIPNWKRCDGHQDCQDGQDEANC 1506
Cdd:pfam00057    2 TCSPNEFQCGS-GECIPRSWVCDGDPDCGDGSDEENC 37
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1470-1503 2.64e-06

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 45.32  E-value: 2.64e-06
                            10        20        30
                    ....*....|....*....|....*....|....
gi 1958795120  1470 QCDRFEFECRqPKKCIPNWKRCDGHQDCQDGQDE 1503
Cdd:smart00192    1 TCPPGEFQCD-NGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1117-1153 5.40e-06

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 44.55  E-value: 5.40e-06
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1958795120 1117 CDADtQFRCQeSGTCIPLSYKCDLEDDCGDNSDESHC 1153
Cdd:pfam00057    3 CSPN-EFQCG-SGECIPRSWVCDGDPDCGDGSDEENC 37
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 868-910 2.60e-05

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 42.59  E-value: 2.60e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1958795120   868 TIVNSSvLDRPRALVLVPQEGVMFWTDWGdlKPGIYRSNMDGS 910
Cdd:smart00135    2 TLLSSG-LGHPNGLAVDWIEGRLYWTDWG--LDVIEVANLDGT 41
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 780-821 1.04e-04

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 41.05  E-value: 1.04e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 1958795120   780 EQLPLSGLRAAVALDFDYEHNCLYWSDLALDTIQRLCLNGST 821
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTN 42
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1281-1308 2.55e-04

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 39.54  E-value: 2.55e-04
                            10        20
                    ....*....|....*....|....*...
gi 1958795120  1281 FVCKNRQqCLFHSMVCDGIIQCRDGSDE 1308
Cdd:smart00192    7 FQCDNGR-CIPSSWVCDGVDDCGDGSDE 33
PRKCSH-like pfam12999
Glucosidase II beta subunit-like; The sequences found in this family are similar to a region ...
 1166-1240 2.76e-04

Glucosidase II beta subunit-like; The sequences found in this family are similar to a region found in the beta-subunit of glucosidase II, which is also known as protein kinase C substrate 80K-H (PRKCSH). The enzyme catalyzes the sequential removal of two alpha-1,3-linked glucose residues in the second step of N-linked oligosaccharide processing. The beta subunit is required for the solubility and stability of the heterodimeric enzyme, and is involved in retaining the enzyme within the endoplasmic reticulum.


Pssm-ID: 372423 [Multi-domain]  Cd Length: 176  Bit Score: 43.24  E-value: 2.76e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958795120 1166 SSGMCIRSSWVCDGDNDCRDWSDEANCTAiyhtCEASNFQCHN-GHC---IPQRWACDGDAD---CQDGSDEDPISCEKK 1238
Cdd:pfam12999   43 HSEIKLSFDQVNDDYCDCPDGSDEPGTNA----CSNGKFYCANeGFIpgyIPSFKVDDGVCDydiCCDGSDEALGKCPNK 118


                   ..
gi 1958795120 1239 CN 1240
Cdd:pfam12999  119 CG 120
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 798-937 3.75e-04

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 44.11  E-value: 3.75e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958795120  798 EHNCLYWSDLALDTIQRLCLNGSTGQEVIINSGLetVEALAFEPLSQL--------LYWVDAGFKKIEVANPDGDFRLTI 869
Cdd:COG3386     17 PDGRLYWVDIPGGRIHRYDPDGGAVEVFAEPSGR--PNGLAFDPDGRLlvadhgrgLVRFDPADGEVTVLADEYGKPLNR 94

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958795120  870 VNSSVLDRpralvlvpqEGVMFWTDWGDLKP--GIYRSNMDGSAayRLVSEDVKWPNGI--SVDGHWIYWTD 937
Cdd:COG3386     95 PNDGVVDP---------DGRLYFTDMGEYLPtgALYRVDPDGSL--RVLADGLTFPNGIafSPDGRTLYVAD 155
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1281-1309 7.10e-04

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 38.34  E-value: 7.10e-04
                           10        20
                   ....*....|....*....|....*....
gi 1958795120 1281 FVCKNRQqCLFHSMVCDGIIQCRDGSDED 1309
Cdd:cd00112      6 FRCANGR-CIPSSWVCDGEDDCGDGSDEE 33
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 933-969 1.94e-03

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 37.52  E-value: 1.94e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1958795120  933 IYWTDAYLDC-IERITFSGQQRSVIL-DNLPHPYAIAVF 969
Cdd:pfam00058    3 LYWTDSSLRAsISSADLNGSDRKTLFtDDLQHPNAIAVD 41
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 953-987 4.04e-03

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 36.43  E-value: 4.04e-03
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 1958795120   953 RSVILDNLPHPYAIAV--FKNEIYWDDWSQLSIFRAS 987
Cdd:smart00135    1 RTLLSSGLGHPNGLAVdwIEGRLYWTDWGLDVIEVAN 37
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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