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Conserved domains on  [gi|1958668704|ref|XP_038945372|]
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protein strawberry notch homolog 1 isoform X6 [Rattus norvegicus]

Protein Classification

strawberry notch family protein( domain architecture ID 10620596)

strawberry notch (SBNO) family protein similar to Drosophila melanogaster protein strawberry notch that is a Notch pathway component and may contribute to the specificity between lateral and inductive Notch signaling pathways in the wing disk

CATH:  3.40.50.300
Gene Ontology:  GO:0006355|GO:0031490|GO:0042393
PubMed:  8287794

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
AAA_34 pfam13872
P-loop containing NTP hydrolase pore-1;
51-353 0e+00

P-loop containing NTP hydrolase pore-1;


:

Pssm-ID: 464010  Cd Length: 300  Bit Score: 573.73  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668704   51 DAVVETSSLSSVTPPDVWYKTSISEETIDNGWLSALQLEAVTYAAQQHETFLPNGDRAGFLIGDGAGVGKGRTIAGIIYE 130
Cdd:pfam13872    1 DPLVESASLASVAPPDPTYRLALPGDVIDSGLLSALQLEAVIYACQAHEQFLPDGFRAGFFLGDGAGVGKGRQIAGIILE 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668704  131 NYLLSRKRALWFSVSNDLKYDAERDLRDIGAKNILVHSLNKFKYG-KISSkhNGSVKKGVIFATYSSLIGESQSGGKykT 209
Cdd:pfam13872   81 NWLQGRRRALWVSVSNDLKEDAERDLRDIGGSRIDVQPLNKFKYGdKISE--NGRLKEGVLFSTYSTLISESKGGKK--S 156
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668704  210 RLKQLLHWCGDDFDGVIVFDECHKAKNLCPVGSSKPTKTGLAVLELQNKLPKARVVYASATGASEPRNMAYMNRLGIWGE 289
Cdd:pfam13872  157 RLQQLVDWLGEDFDGVIVFDECHKAKNLAPGGSKKPTKQGLAVLELQNALPNARVVYASATGASEPRNLAYMVRLGLWGP 236
                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958668704  290 GTPFREFSDFIQAVERRGVGAMEIVAMDMKLRGMYIARQLSFTGVTFKIEEVLLSQSYVKMYNK 353
Cdd:pfam13872  237 GTPFPDFEDFINAMEKRGVGAMELVAMDLKARGLYVARQLSFEGVEFEILEHELSPEQIRVYDA 300
Helicase_C_4 pfam13871
C-terminal domain on Strawberry notch homolog; Strawberry notch proteins carry DExD/H-box ...
665-941 2.17e-167

C-terminal domain on Strawberry notch homolog; Strawberry notch proteins carry DExD/H-box groups upstream of this domain. The function of this domain is not known. These proteins promote the expression of diverse targets, potentially through interactions with transcriptional activator or repressor complexes.


:

Pssm-ID: 464009  Cd Length: 269  Bit Score: 495.54  E-value: 2.17e-167
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668704  665 NTLDELIDELGGPENVAEMTGRKGRVVSNDDGSISYESRSELDVPVEILNITEKQRFMDGDKNIAIISEAASSGISLQAD 744
Cdd:pfam13871    1 NALDQLIDHLGGPENVAEMTGRSGRIVRKDDGRVVYESRSESDVPLESANLAEKQAFMDGEKLIAIISDAASTGISLHAD 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668704  745 RRAKNQRRRVHMTLELPWSADRAIQQFGRTHRSNQVTAPEYVFLISELAGEQRFASIVAKRLESLGALTHGDRRA-TESR 823
Cdd:pfam13871   81 RRAKNQRRRVHITLELPWSADKAIQQFGRTHRSNQASAPEYRPLTTDLKGERRFASTVARRLDSLGALTRGDRRAgGQGL 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668704  824 DLSRFNFDNKYGRNALEIVMKSIVNLDSPMVSPPPDYpgeffKDVRQGLIGVGLINVEdrsgILTLDKDYNNIGKFLNRI 903
Cdd:pfam13871  161 DLSEDNLDSKYGRRALRQVYQLIVGGKLPGVSLPEFE-----SMTGLALLDVGLLKAE----IEILDKDLPPIPRFLNRI 231
                          250       260       270
                   ....*....|....*....|....*....|....*...
gi 1958668704  904 LGMEVHQQNALFQYFADTLTAVVQNAKKNGRYDMGILD 941
Cdd:pfam13871  232 LGLPVELQNALFEYFEDTLEARIEQAKAAGTYDLGIED 269
 
Name Accession Description Interval E-value
AAA_34 pfam13872
P-loop containing NTP hydrolase pore-1;
51-353 0e+00

P-loop containing NTP hydrolase pore-1;


Pssm-ID: 464010  Cd Length: 300  Bit Score: 573.73  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668704   51 DAVVETSSLSSVTPPDVWYKTSISEETIDNGWLSALQLEAVTYAAQQHETFLPNGDRAGFLIGDGAGVGKGRTIAGIIYE 130
Cdd:pfam13872    1 DPLVESASLASVAPPDPTYRLALPGDVIDSGLLSALQLEAVIYACQAHEQFLPDGFRAGFFLGDGAGVGKGRQIAGIILE 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668704  131 NYLLSRKRALWFSVSNDLKYDAERDLRDIGAKNILVHSLNKFKYG-KISSkhNGSVKKGVIFATYSSLIGESQSGGKykT 209
Cdd:pfam13872   81 NWLQGRRRALWVSVSNDLKEDAERDLRDIGGSRIDVQPLNKFKYGdKISE--NGRLKEGVLFSTYSTLISESKGGKK--S 156
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668704  210 RLKQLLHWCGDDFDGVIVFDECHKAKNLCPVGSSKPTKTGLAVLELQNKLPKARVVYASATGASEPRNMAYMNRLGIWGE 289
Cdd:pfam13872  157 RLQQLVDWLGEDFDGVIVFDECHKAKNLAPGGSKKPTKQGLAVLELQNALPNARVVYASATGASEPRNLAYMVRLGLWGP 236
                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958668704  290 GTPFREFSDFIQAVERRGVGAMEIVAMDMKLRGMYIARQLSFTGVTFKIEEVLLSQSYVKMYNK 353
Cdd:pfam13872  237 GTPFPDFEDFINAMEKRGVGAMELVAMDLKARGLYVARQLSFEGVEFEILEHELSPEQIRVYDA 300
Helicase_C_4 pfam13871
C-terminal domain on Strawberry notch homolog; Strawberry notch proteins carry DExD/H-box ...
665-941 2.17e-167

C-terminal domain on Strawberry notch homolog; Strawberry notch proteins carry DExD/H-box groups upstream of this domain. The function of this domain is not known. These proteins promote the expression of diverse targets, potentially through interactions with transcriptional activator or repressor complexes.


Pssm-ID: 464009  Cd Length: 269  Bit Score: 495.54  E-value: 2.17e-167
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668704  665 NTLDELIDELGGPENVAEMTGRKGRVVSNDDGSISYESRSELDVPVEILNITEKQRFMDGDKNIAIISEAASSGISLQAD 744
Cdd:pfam13871    1 NALDQLIDHLGGPENVAEMTGRSGRIVRKDDGRVVYESRSESDVPLESANLAEKQAFMDGEKLIAIISDAASTGISLHAD 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668704  745 RRAKNQRRRVHMTLELPWSADRAIQQFGRTHRSNQVTAPEYVFLISELAGEQRFASIVAKRLESLGALTHGDRRA-TESR 823
Cdd:pfam13871   81 RRAKNQRRRVHITLELPWSADKAIQQFGRTHRSNQASAPEYRPLTTDLKGERRFASTVARRLDSLGALTRGDRRAgGQGL 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668704  824 DLSRFNFDNKYGRNALEIVMKSIVNLDSPMVSPPPDYpgeffKDVRQGLIGVGLINVEdrsgILTLDKDYNNIGKFLNRI 903
Cdd:pfam13871  161 DLSEDNLDSKYGRRALRQVYQLIVGGKLPGVSLPEFE-----SMTGLALLDVGLLKAE----IEILDKDLPPIPRFLNRI 231
                          250       260       270
                   ....*....|....*....|....*....|....*...
gi 1958668704  904 LGMEVHQQNALFQYFADTLTAVVQNAKKNGRYDMGILD 941
Cdd:pfam13871  232 LGLPVELQNALFEYFEDTLEARIEQAKAAGTYDLGIED 269
SSL2 COG1061
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
117-270 1.61e-06

Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];


Pssm-ID: 440681 [Multi-domain]  Cd Length: 566  Bit Score: 52.33  E-value: 1.61e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668704  117 GVGKGRTIAGIIYEnyLLSRKRALWFSVSNDLKYDAERDLRdigaknilvhslnKFKYGKISSKHNGSVKKGVIFATYSS 196
Cdd:COG1061    110 GTGKTVLALALAAE--LLRGKRVLVLVPRRELLEQWAEELR-------------RFLGDPLAGGGKKDSDAPITVATYQS 174
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958668704  197 LIGESQsggkyktrlkqlLHWCGDDFDgVIVFDECHKAknlcpvgsskPTKTGLAVLELqnkLPKARVVYASAT 270
Cdd:COG1061    175 LARRAH------------LDELGDRFG-LVIIDEAHHA----------GAPSYRRILEA---FPAAYRLGLTAT 222
SF2-N cd00046
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ...
117-270 2.72e-05

N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.


Pssm-ID: 350668 [Multi-domain]  Cd Length: 146  Bit Score: 45.47  E-value: 2.72e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668704  117 GVGKGRTIAGIIYENYLLSRKRALWFSVSNDLKYDAERDLRDIGAKNILVHSLnkfkYGKISSKHNGSVKKG---VIFAT 193
Cdd:cd00046     11 GSGKTLAALLAALLLLLKKGKKVLVLVPTKALALQTAERLRELFGPGIRVAVL----VGGSSAEEREKNKLGdadIIIAT 86
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958668704  194 YSSLIgesqsggkykTRLKQLLHWCGDDFDgVIVFDECHKaknlcpVGSSKPTKTGLAVLELQNKLPKARVVYASAT 270
Cdd:cd00046     87 PDMLL----------NLLLREDRLFLKDLK-LIIVDEAHA------LLIDSRGALILDLAVRKAGLKNAQVILLSAT 146
 
Name Accession Description Interval E-value
AAA_34 pfam13872
P-loop containing NTP hydrolase pore-1;
51-353 0e+00

P-loop containing NTP hydrolase pore-1;


Pssm-ID: 464010  Cd Length: 300  Bit Score: 573.73  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668704   51 DAVVETSSLSSVTPPDVWYKTSISEETIDNGWLSALQLEAVTYAAQQHETFLPNGDRAGFLIGDGAGVGKGRTIAGIIYE 130
Cdd:pfam13872    1 DPLVESASLASVAPPDPTYRLALPGDVIDSGLLSALQLEAVIYACQAHEQFLPDGFRAGFFLGDGAGVGKGRQIAGIILE 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668704  131 NYLLSRKRALWFSVSNDLKYDAERDLRDIGAKNILVHSLNKFKYG-KISSkhNGSVKKGVIFATYSSLIGESQSGGKykT 209
Cdd:pfam13872   81 NWLQGRRRALWVSVSNDLKEDAERDLRDIGGSRIDVQPLNKFKYGdKISE--NGRLKEGVLFSTYSTLISESKGGKK--S 156
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668704  210 RLKQLLHWCGDDFDGVIVFDECHKAKNLCPVGSSKPTKTGLAVLELQNKLPKARVVYASATGASEPRNMAYMNRLGIWGE 289
Cdd:pfam13872  157 RLQQLVDWLGEDFDGVIVFDECHKAKNLAPGGSKKPTKQGLAVLELQNALPNARVVYASATGASEPRNLAYMVRLGLWGP 236
                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958668704  290 GTPFREFSDFIQAVERRGVGAMEIVAMDMKLRGMYIARQLSFTGVTFKIEEVLLSQSYVKMYNK 353
Cdd:pfam13872  237 GTPFPDFEDFINAMEKRGVGAMELVAMDLKARGLYVARQLSFEGVEFEILEHELSPEQIRVYDA 300
Helicase_C_4 pfam13871
C-terminal domain on Strawberry notch homolog; Strawberry notch proteins carry DExD/H-box ...
665-941 2.17e-167

C-terminal domain on Strawberry notch homolog; Strawberry notch proteins carry DExD/H-box groups upstream of this domain. The function of this domain is not known. These proteins promote the expression of diverse targets, potentially through interactions with transcriptional activator or repressor complexes.


Pssm-ID: 464009  Cd Length: 269  Bit Score: 495.54  E-value: 2.17e-167
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668704  665 NTLDELIDELGGPENVAEMTGRKGRVVSNDDGSISYESRSELDVPVEILNITEKQRFMDGDKNIAIISEAASSGISLQAD 744
Cdd:pfam13871    1 NALDQLIDHLGGPENVAEMTGRSGRIVRKDDGRVVYESRSESDVPLESANLAEKQAFMDGEKLIAIISDAASTGISLHAD 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668704  745 RRAKNQRRRVHMTLELPWSADRAIQQFGRTHRSNQVTAPEYVFLISELAGEQRFASIVAKRLESLGALTHGDRRA-TESR 823
Cdd:pfam13871   81 RRAKNQRRRVHITLELPWSADKAIQQFGRTHRSNQASAPEYRPLTTDLKGERRFASTVARRLDSLGALTRGDRRAgGQGL 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668704  824 DLSRFNFDNKYGRNALEIVMKSIVNLDSPMVSPPPDYpgeffKDVRQGLIGVGLINVEdrsgILTLDKDYNNIGKFLNRI 903
Cdd:pfam13871  161 DLSEDNLDSKYGRRALRQVYQLIVGGKLPGVSLPEFE-----SMTGLALLDVGLLKAE----IEILDKDLPPIPRFLNRI 231
                          250       260       270
                   ....*....|....*....|....*....|....*...
gi 1958668704  904 LGMEVHQQNALFQYFADTLTAVVQNAKKNGRYDMGILD 941
Cdd:pfam13871  232 LGLPVELQNALFEYFEDTLEARIEQAKAAGTYDLGIED 269
SSL2 COG1061
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
117-270 1.61e-06

Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];


Pssm-ID: 440681 [Multi-domain]  Cd Length: 566  Bit Score: 52.33  E-value: 1.61e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668704  117 GVGKGRTIAGIIYEnyLLSRKRALWFSVSNDLKYDAERDLRdigaknilvhslnKFKYGKISSKHNGSVKKGVIFATYSS 196
Cdd:COG1061    110 GTGKTVLALALAAE--LLRGKRVLVLVPRRELLEQWAEELR-------------RFLGDPLAGGGKKDSDAPITVATYQS 174
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958668704  197 LIGESQsggkyktrlkqlLHWCGDDFDgVIVFDECHKAknlcpvgsskPTKTGLAVLELqnkLPKARVVYASAT 270
Cdd:COG1061    175 LARRAH------------LDELGDRFG-LVIIDEAHHA----------GAPSYRRILEA---FPAAYRLGLTAT 222
ResIII pfam04851
Type III restriction enzyme, res subunit;
87-234 1.22e-05

Type III restriction enzyme, res subunit;


Pssm-ID: 398492 [Multi-domain]  Cd Length: 162  Bit Score: 46.90  E-value: 1.22e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668704   87 QLEAVTYAAQQHEtflpNGDRAGFLIGdGAGVGKGRTIAGIIYENYLLSRKRALWFSV-SNDLKYDAERDLRDIGAKNil 165
Cdd:pfam04851    8 QIEAIENLLESIK----NGQKRGLIVM-ATGSGKTLTAAKLIARLFKKGPIKKVLFLVpRKDLLEQALEEFKKFLPNY-- 80
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958668704  166 vHSLNKFKYG--KISSKHNGSVkkgvIFATYSSLIGESQSGGKYKtrlkqllhwcGDDFDGVIVFDECHKA 234
Cdd:pfam04851   81 -VEIGEIISGdkKDESVDDNKI----VVTTIQSLYKALELASLEL----------LPDFFDVIIIDEAHRS 136
SF2-N cd00046
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ...
117-270 2.72e-05

N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.


Pssm-ID: 350668 [Multi-domain]  Cd Length: 146  Bit Score: 45.47  E-value: 2.72e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668704  117 GVGKGRTIAGIIYENYLLSRKRALWFSVSNDLKYDAERDLRDIGAKNILVHSLnkfkYGKISSKHNGSVKKG---VIFAT 193
Cdd:cd00046     11 GSGKTLAALLAALLLLLKKGKKVLVLVPTKALALQTAERLRELFGPGIRVAVL----VGGSSAEEREKNKLGdadIIIAT 86
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958668704  194 YSSLIgesqsggkykTRLKQLLHWCGDDFDgVIVFDECHKaknlcpVGSSKPTKTGLAVLELQNKLPKARVVYASAT 270
Cdd:cd00046     87 PDMLL----------NLLLREDRLFLKDLK-LIIVDEAHA------LLIDSRGALILDLAVRKAGLKNAQVILLSAT 146
DEXHc_RE_I_III_res cd18032
DEXH-box helicase domain of type III restriction enzyme res subunit; Members of this model ...
117-234 1.30e-03

DEXH-box helicase domain of type III restriction enzyme res subunit; Members of this model includes both type I and type III restriction enzymes. Both are hetero-oligomeric proteins. Type I REs are encoded by three closely linked genes: a specificity subunit (HsdS or S) for recognizing a DNA sequence, a methylation subunit (HsdM or M) for methylating the recognized target bases, and a restriction subunit (HsdR or R) for the translocation and random cleavage of non-methylated DNA. They show diverse catalytic activities, including methyltransferase (MTase), ATP hydrolase (ATPase), DNA translocation and restriction activities. These enzymes cut at a site that differs, and is a random distance (at least 1000 bp) away, from their recognition site. Cleavage at these random sites follows a process of DNA translocation, which shows that these enzymes are also molecular motors. The recognition site is asymmetrical and is composed of two specific portions: one containing 3-4 nucleotides, and another containing 4-5 nucleotides, separated by a non-specific spacer of about 6-8 nucleotides. Type III enzymes are composed of two subunits, Res and Mod. The Mod subunit recognizes the DNA sequence specific for the system and is a modification methyltransferase; as such, it is functionally equivalent to the M and S subunits of type I restriction endonucleases. Res is required for restriction, although it has no enzymatic activity on its own. Type III enzymes recognize short 5-6 bp-long asymmetric DNA sequences and cleave 25-27 bp downstream to leave short, single-stranded 5' protrusions. They require the presence of two inversely oriented unmethylated recognition sites for restriction to occur. These enzymes methylate only one strand of the DNA, at the N-6 position of adenosyl residues, so newly replicated DNA will have only one strand methylated, which is sufficient to protect against restriction. Both type I and type III REs are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350790 [Multi-domain]  Cd Length: 163  Bit Score: 40.62  E-value: 1.30e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668704  117 GVGKGRTIAGIIYeNYLLSR--KRALWFSVSNDLKYDAERDLRDIgaknilvhsLNKFKYGKISSKHNGSVKKGVIFATY 194
Cdd:cd18032     30 GTGKTYTAAFLIK-RLLEANrkKRILFLAHREELLEQAERSFKEV---------LPDGSFGNLKGGKKKPDDARVVFATV 99
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 1958668704  195 SSLIGESqsggkyktRLKQLLHwcgDDFDGVIVfDECHKA 234
Cdd:cd18032    100 QTLNKRK--------RLEKFPP---DYFDLIII-DEAHHA 127
DEXHc_RE cd17926
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family ...
87-232 3.83e-03

DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family is composed of helicase restriction enzymes and similar proteins such as TFIIH basal transcription factor complex helicase XPB subunit. These proteins are part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350684 [Multi-domain]  Cd Length: 146  Bit Score: 39.21  E-value: 3.83e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668704   87 QLEAVTYAAQQHetflpNGDRAGFLIGDGAGvgKGRTIAGIIYEnylLSRKRALWFSVSNDLKYDAERDLRDIGAKnilv 166
Cdd:cd17926      5 QEEALEAWLAHK-----NNRRGILVLPTGSG--KTLTALALIAY---LKELRTLIVVPTDALLDQWKERFEDFLGD---- 70
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958668704  167 HSLNKFKYGKISSKHNGSVkkgvIFATYSSLIGESQSGGKYKtrlkqllhwcgdDFDGVIVFDECH 232
Cdd:cd17926     71 SSIGLIGGGKKKDFDDANV----VVATYQSLSNLAEEEKDLF------------DQFGLLIVDEAH 120
Helicase_C pfam00271
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ...
695-778 8.09e-03

Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.


Pssm-ID: 459740 [Multi-domain]  Cd Length: 109  Bit Score: 37.19  E-value: 8.09e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668704  695 DGSISYESRseldvpVEILnitekQRFMDGDKNIAIISEAASSGISLQAdrraknqRRRVHMtLELPWSADRAIQQFGRT 774
Cdd:pfam00271   45 HGDLSQEER------EEIL-----EDFRKGKIDVLVATDVAERGLDLPD-------VDLVIN-YDLPWNPASYIQRIGRA 105

                   ....
gi 1958668704  775 HRSN 778
Cdd:pfam00271  106 GRAG 109
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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