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Conserved domains on  [gi|1958711632|ref|XP_038951776|]
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queuosine 5'-phosphate N-glycosylase/hydrolase isoform X1 [Rattus norvegicus]

Protein Classification

queuosine salvage family protein( domain architecture ID 5543)

queuosine salvage family protein is involved in salvaging queuosine, similar to Homo sapiens queuosine 5'-phosphate N-glycosylase/hydrolase that catalyzes the hydrolysis of queuosine 5'-phosphate, releasing the nucleobase queuine (q)

EC:  3.2.2.-
Gene Ontology:  GO:0101030|GO:0043174|GO:0016787
PubMed:  24911101

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Q_salvage super family cl11011
Potential Queuosine, Q, salvage protein family; Q_salvage proteins occur in most Eukarya as ...
 55-201 4.40e-87

Potential Queuosine, Q, salvage protein family; Q_salvage proteins occur in most Eukarya as well as in a few bacteria possible via horizontal gene-transfer. Queuosine (Q) is a chemical modification found at the wobble position of tRNAs that have GUN anticodons. Most bacteria synthesize queuosine de novo, whereas eukaryotes rely solely on salvaging this essential component from the environment or the gut flora. The exact enzymatic function of the domain has yet to be determined, but structural similarity with DNA glycosidases suggests a ribonucleoside hydrolase role.


The actual alignment was detected with superfamily member pfam10343:

Pssm-ID: 463052  Cd Length: 285  Bit Score: 257.82  E-value: 4.40e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958711632  55 LNPRGSDEAALDWVFMVDSLNFSFWAER-EERKCEVRYGGTAYTGYWALCAAVNRALDQGIPVTSASYYATVTLDQVRNI 133
Cdd:pfam10343   1 LHPKDDDESTVDWIFVVDTLNFSFWSEKdEEERFAVEYKGKRYTGYWSLCAALNRALDEGIPITDPKFYSSLTEELLRHI 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958711632 134 FRSDTAVPMPLLEERHRILNETGKILLEKFGGSFLNCVQKSGKSAQKLMHLIVENFPSYRDEAWFEEK 201
Cdd:pfam10343  81 FRSDTEEEIPLLEERLRCLREAGRVLLEKFDGSFVNCIKAANGSAAKLVNLLVENFPSFRDEAVYEGR 148
 
Name Accession Description Interval E-value
Q_salvage pfam10343
Potential Queuosine, Q, salvage protein family; Q_salvage proteins occur in most Eukarya as ...
 55-201 4.40e-87

Potential Queuosine, Q, salvage protein family; Q_salvage proteins occur in most Eukarya as well as in a few bacteria possible via horizontal gene-transfer. Queuosine (Q) is a chemical modification found at the wobble position of tRNAs that have GUN anticodons. Most bacteria synthesize queuosine de novo, whereas eukaryotes rely solely on salvaging this essential component from the environment or the gut flora. The exact enzymatic function of the domain has yet to be determined, but structural similarity with DNA glycosidases suggests a ribonucleoside hydrolase role.


Pssm-ID: 463052  Cd Length: 285  Bit Score: 257.82  E-value: 4.40e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958711632  55 LNPRGSDEAALDWVFMVDSLNFSFWAER-EERKCEVRYGGTAYTGYWALCAAVNRALDQGIPVTSASYYATVTLDQVRNI 133
Cdd:pfam10343   1 LHPKDDDESTVDWIFVVDTLNFSFWSEKdEEERFAVEYKGKRYTGYWSLCAALNRALDEGIPITDPKFYSSLTEELLRHI 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958711632 134 FRSDTAVPMPLLEERHRILNETGKILLEKFGGSFLNCVQKSGKSAQKLMHLIVENFPSYRDEAWFEEK 201
Cdd:pfam10343  81 FRSDTEEEIPLLEERLRCLREAGRVLLEKFDGSFVNCIKAANGSAAKLVNLLVENFPSFRDEAVYEGR 148
 
Name Accession Description Interval E-value
Q_salvage pfam10343
Potential Queuosine, Q, salvage protein family; Q_salvage proteins occur in most Eukarya as ...
 55-201 4.40e-87

Potential Queuosine, Q, salvage protein family; Q_salvage proteins occur in most Eukarya as well as in a few bacteria possible via horizontal gene-transfer. Queuosine (Q) is a chemical modification found at the wobble position of tRNAs that have GUN anticodons. Most bacteria synthesize queuosine de novo, whereas eukaryotes rely solely on salvaging this essential component from the environment or the gut flora. The exact enzymatic function of the domain has yet to be determined, but structural similarity with DNA glycosidases suggests a ribonucleoside hydrolase role.


Pssm-ID: 463052  Cd Length: 285  Bit Score: 257.82  E-value: 4.40e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958711632  55 LNPRGSDEAALDWVFMVDSLNFSFWAER-EERKCEVRYGGTAYTGYWALCAAVNRALDQGIPVTSASYYATVTLDQVRNI 133
Cdd:pfam10343   1 LHPKDDDESTVDWIFVVDTLNFSFWSEKdEEERFAVEYKGKRYTGYWSLCAALNRALDEGIPITDPKFYSSLTEELLRHI 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958711632 134 FRSDTAVPMPLLEERHRILNETGKILLEKFGGSFLNCVQKSGKSAQKLMHLIVENFPSYRDEAWFEEK 201
Cdd:pfam10343  81 FRSDTEEEIPLLEERLRCLREAGRVLLEKFDGSFVNCIKAANGSAAKLVNLLVENFPSFRDEAVYEGR 148
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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