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Conserved domains on  [gi|1958807188|ref|XP_038955599|]
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BCL-6 corepressor-like protein 1 isoform X1 [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PUFD_like_1 cd14260
PCGF Ub-like fold discriminator of BCOR-like 1; The PUFD domain binds the RAWUL (RING finger ...
1669-1782 1.05e-65

PCGF Ub-like fold discriminator of BCOR-like 1; The PUFD domain binds the RAWUL (RING finger and WD40-associated ubiquitin-like) domain of the polycomb-group RING finger homologs PCGF1 and PCGF3. PUFD was characterized as a domain of the BCL6 corepressor BCOR. It does not appear to bind to PCGF2 and PCGF4. PCGF1 is a component of the Polycomb group (PcG) multi-protein BCOR complex, which is involved in repressing the transcription of BCL6 and CDKN1A. The BCL-6 corepressor-like protein 1 (BCoR-L1) is largely uncharacterized; it contains ankyrin repeats.


:

Pssm-ID: 271223  Cd Length: 115  Bit Score: 217.79  E-value: 1.05e-65
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188 1669 EQDDFMFELSDKPLLPCYNLQVSVSRGPCNWFLFSDVLKRLKLSSRIFQARFPHLEITTLPKAEFYRQVASSQLLTPAER 1748
Cdd:cd14260      2 EEDDFMFEFSDKPLLPCYNLQVSVSRGPCNWFLFSDVLKRLKLSSRIFQARFPHFEIATMPKAEFYRQVLSSQLLTPAER 81
                           90       100       110
                   ....*....|....*....|....*....|....
gi 1958807188 1749 PGSLEDRSPPGSSETVELVQYEPELLRLLGSEVE 1782
Cdd:cd14260     82 PGGLDDRSPQGSSETVELVRYEPELLRLLGSAVE 115
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1499-1615 1.36e-27

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 114.67  E-value: 1.36e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188 1499 NAGETLLQRAARLGYKDVVLYCLQKHSeDVNHRDNAGYTALHEACSRGWTDILNILLQHGANVNCSSQDGTRPVHDAVVN 1578
Cdd:COG0666    118 KDGETPLHLAAYNGNLEIVKLLLEAGA-DVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAEN 196
                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 1958807188 1579 DNLETIWLLLSYGADPTLATYSGQTAMKLASSDNMKR 1615
Cdd:COG0666    197 GHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLE 233
PHA03247 super family cl33720
large tegument protein UL36; Provisional
201-636 6.17e-14

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 78.06  E-value: 6.17e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188  201 APICPPAPGSASGTPSVPDPFQVPLSVPAPVPHSGLVPVQVATSASAPSPPLAPVPALAPAAPSVPTLISDSNPLSVSAS 280
Cdd:PHA03247  2600 APVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSP 2679
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188  281 VLVPVPVSAPhsvpvplsaPAPTPLTVSVSAPPlaliQAPVPPSAPTLVLASVPTPvlapmpastppaapappsvpmPTP 360
Cdd:PHA03247  2680 PQRPRRRAAR---------PTVGSLTSLADPPP----PPPTPEPAPHALVSATPLP---------------------PGP 2725
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188  361 TPSSGPPSTPTLIPAFAPTPVPAPTPAPIFTPAPTPMPAATPAAIPTSAPI-----------PASFSLSRVCFPAAQAPA 429
Cdd:PHA03247  2726 AAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAagpprrltrpaVASLSESRESLPSPWDPA 2805
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188  430 MQKVPLSFQPGTVLTPNQPLVYIPPPSCGQPLSVATLPTTLGVSSTLTLPVLPsylqdrclpgvlASPELRSYPYAFSVA 509
Cdd:PHA03247  2806 DPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAP------------GGDVRRRPPSRSPAA 2873
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188  510 RPLASDSKLVSlevnRLSCTSPSSSTNSQPAPEGVPGP-----LADTSLTTASAKVLPTSQPLLPAPSGSSVPLHPSKMP 584
Cdd:PHA03247  2874 KPAAPARPPVR----RLARPAVSRSTESFALPPDQPERppqpqAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDP 2949
                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1958807188  585 GGTDQQTEGTSVTFSPLKSPPQLE--REMASPPECSeMPLDLSSKSNRQKLPLP 636
Cdd:PHA03247  2950 AGAGEPSGAVPQPWLGALVPGRVAvpRFRVPQPAPS-REAPASSTPPLTGHSLS 3002
 
Name Accession Description Interval E-value
PUFD_like_1 cd14260
PCGF Ub-like fold discriminator of BCOR-like 1; The PUFD domain binds the RAWUL (RING finger ...
1669-1782 1.05e-65

PCGF Ub-like fold discriminator of BCOR-like 1; The PUFD domain binds the RAWUL (RING finger and WD40-associated ubiquitin-like) domain of the polycomb-group RING finger homologs PCGF1 and PCGF3. PUFD was characterized as a domain of the BCL6 corepressor BCOR. It does not appear to bind to PCGF2 and PCGF4. PCGF1 is a component of the Polycomb group (PcG) multi-protein BCOR complex, which is involved in repressing the transcription of BCL6 and CDKN1A. The BCL-6 corepressor-like protein 1 (BCoR-L1) is largely uncharacterized; it contains ankyrin repeats.


Pssm-ID: 271223  Cd Length: 115  Bit Score: 217.79  E-value: 1.05e-65
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188 1669 EQDDFMFELSDKPLLPCYNLQVSVSRGPCNWFLFSDVLKRLKLSSRIFQARFPHLEITTLPKAEFYRQVASSQLLTPAER 1748
Cdd:cd14260      2 EEDDFMFEFSDKPLLPCYNLQVSVSRGPCNWFLFSDVLKRLKLSSRIFQARFPHFEIATMPKAEFYRQVLSSQLLTPAER 81
                           90       100       110
                   ....*....|....*....|....*....|....
gi 1958807188 1749 PGSLEDRSPPGSSETVELVQYEPELLRLLGSEVE 1782
Cdd:cd14260     82 PGGLDDRSPQGSSETVELVRYEPELLRLLGSAVE 115
PUFD pfam16553
BCORL-PCGF1-binding domain; PUFD is the minimal domain at the C-terminus of BCORL (BCL6 ...
1671-1787 1.13e-61

BCORL-PCGF1-binding domain; PUFD is the minimal domain at the C-terminus of BCORL (BCL6 corepressor) that is needed for binding and giving specificity to some of the PCGF proteins, polycomb-group RING finger homologs. PUFD binds to the RAWUL (RING finger- and WD40-associated ubiquitin-like) domain of the particular PCGF PCGF1, pfam16207. Polycomb group proteins form repressive complexes (PRC) that mediate epigenetic modifications of histones. In humans there are many different PCGF homologs whose functions all vary, but the direct binding partner of PCGF1 is BCOR. BCOR has emerged as an important player in development and health.


Pssm-ID: 465171  Cd Length: 114  Bit Score: 206.08  E-value: 1.13e-61
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188 1671 DDFMFELSDKPLLPCYNLQVSVSRGPCNWFLFSDVLKRLKLSSRIFQARFPHLEITTLPKAEFYRQVASSQLLTPAERPG 1750
Cdd:pfam16553    2 DVFEFEFSDKPLLPCYNIQVSLSQGPRNWLLLSDVLKRLKMSSRIFRARFPHFEVVTIAEAEFYKQVSLSQLLSPPEDLE 81
                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 1958807188 1751 SledrSPPGSSETVELVQYEPELLRLLGSEVEYQSWS 1787
Cdd:pfam16553   82 A----FNPDSKELVELVEFTPELQTLLGSSVEFLHPS 114
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1499-1615 1.36e-27

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 114.67  E-value: 1.36e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188 1499 NAGETLLQRAARLGYKDVVLYCLQKHSeDVNHRDNAGYTALHEACSRGWTDILNILLQHGANVNCSSQDGTRPVHDAVVN 1578
Cdd:COG0666    118 KDGETPLHLAAYNGNLEIVKLLLEAGA-DVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAEN 196
                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 1958807188 1579 DNLETIWLLLSYGADPTLATYSGQTAMKLASSDNMKR 1615
Cdd:COG0666    197 GHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLE 233
Ank_2 pfam12796
Ankyrin repeats (3 copies);
1505-1596 1.04e-16

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 76.69  E-value: 1.04e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188 1505 LQRAARLGYKDVVLYCLQKHSeDVNHRDNAGYTALHEACSRGWTDILNILLQHgANVNCSSQDGTrPVHDAVVNDNLETI 1584
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGA-DANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKDNGRT-ALHYAARSGHLEIV 77
                           90
                   ....*....|..
gi 1958807188 1585 WLLLSYGADPTL 1596
Cdd:pfam12796   78 KLLLEKGADINV 89
PHA03247 PHA03247
large tegument protein UL36; Provisional
201-636 6.17e-14

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 78.06  E-value: 6.17e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188  201 APICPPAPGSASGTPSVPDPFQVPLSVPAPVPHSGLVPVQVATSASAPSPPLAPVPALAPAAPSVPTLISDSNPLSVSAS 280
Cdd:PHA03247  2600 APVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSP 2679
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188  281 VLVPVPVSAPhsvpvplsaPAPTPLTVSVSAPPlaliQAPVPPSAPTLVLASVPTPvlapmpastppaapappsvpmPTP 360
Cdd:PHA03247  2680 PQRPRRRAAR---------PTVGSLTSLADPPP----PPPTPEPAPHALVSATPLP---------------------PGP 2725
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188  361 TPSSGPPSTPTLIPAFAPTPVPAPTPAPIFTPAPTPMPAATPAAIPTSAPI-----------PASFSLSRVCFPAAQAPA 429
Cdd:PHA03247  2726 AAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAagpprrltrpaVASLSESRESLPSPWDPA 2805
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188  430 MQKVPLSFQPGTVLTPNQPLVYIPPPSCGQPLSVATLPTTLGVSSTLTLPVLPsylqdrclpgvlASPELRSYPYAFSVA 509
Cdd:PHA03247  2806 DPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAP------------GGDVRRRPPSRSPAA 2873
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188  510 RPLASDSKLVSlevnRLSCTSPSSSTNSQPAPEGVPGP-----LADTSLTTASAKVLPTSQPLLPAPSGSSVPLHPSKMP 584
Cdd:PHA03247  2874 KPAAPARPPVR----RLARPAVSRSTESFALPPDQPERppqpqAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDP 2949
                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1958807188  585 GGTDQQTEGTSVTFSPLKSPPQLE--REMASPPECSeMPLDLSSKSNRQKLPLP 636
Cdd:PHA03247  2950 AGAGEPSGAVPQPWLGALVPGRVAvpRFRVPQPAPS-REAPASSTPPLTGHSLS 3002
PHA03100 PHA03100
ankyrin repeat protein; Provisional
1502-1593 3.16e-10

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 64.30  E-value: 3.16e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188 1502 ETLLQRAARLGYKDVVLYCLqKHSEDVNHRDNAGYTALHEACSRGWTDILNILLQHGANVNCSSQDGTRPVHDAVVNDNL 1581
Cdd:PHA03100   160 KLLIDKGVDINAKNRVNYLL-SYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNK 238
                           90
                   ....*....|..
gi 1958807188 1582 ETIWLLLSYGAD 1593
Cdd:PHA03100   239 EIFKLLLNNGPS 250
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
218-664 7.02e-07

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 54.39  E-value: 7.02e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188  218 PDPFQVPLSVPAPVPHSGLVPVQVATSASAPSPPLAPVPALAPAAPSVPTLISDSNPLSV--SASVLVPVPVSAPHSVPV 295
Cdd:pfam03154  171 PPVLQAQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPHTLiqQTPTLHPQRLPSPHPPLQ 250
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188  296 PLSAPAPtPLTVSVSAPPLALIQAPVPP------SAPTLVLASVPTpvlapMPASTPPAAPAPPSVPMPTPTPSSGPPST 369
Cdd:pfam03154  251 PMTQPPP-PSQVSPQPLPQPSLHGQMPPmphslqTGPSHMQHPVPP-----QPFPLTPQSSQSQVPPGPSPAAPGQSQQR 324
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188  370 PTLIPAFAPTPVPAPTPAPIFTPAPTPMPAATPaaiPTSAPIPAsfslsrvcFPAAQA---PAMQKVPLSFQPGTVLtpn 446
Cdd:pfam03154  325 IHTPPSQSQLQSQQPPREQPLPPAPLSMPHIKP---PPTTPIPQ--------LPNPQShkhPPHLSGPSPFQMNSNL--- 390
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188  447 qplvyiPPPSCGQPLSvaTLPTTLGVSStlTLPVLPSYLQDRCLPGVLASPelrsypyafsvarPLASDSKLVSLEVNRL 526
Cdd:pfam03154  391 ------PPPPALKPLS--SLSTHHPPSA--HPPPLQLMPQSQQLPPPPAQP-------------PVLTQSQSLPPPAASH 447
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188  527 SCTSPSSSTNSQP-------APEGVPGPLADTSLTTASAKVLPTSQPLLPAPSGSSVPLhpskmPGGTDQQTEGTSVTFS 599
Cdd:pfam03154  448 PPTSGLHQVPSQSpfpqhpfVPGGPPPITPPSGPPTSTSSAMPGIQPPSSASVSSSGPV-----PAAVSCPLPPVQIKEE 522
                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958807188  600 PLKSPPQLEremaSPPecsempldlssksnrqklPLPNQRKTPPMPVLTPVHTSSKALLSTVLSR 664
Cdd:pfam03154  523 ALDEAEEPE----SPP------------------PPPRSPSPEPTVVNTPSHASQSARFYKHLDR 565
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
1535-1563 5.90e-06

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 44.50  E-value: 5.90e-06
                            10        20
                    ....*....|....*....|....*....
gi 1958807188  1535 GYTALHEACSRGWTDILNILLQHGANVNC 1563
Cdd:smart00248    2 GRTPLHLAAENGNLEVVKLLLDKGADINA 30
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
1494-1593 8.20e-04

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 44.23  E-value: 8.20e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188 1494 LIVNKNAGETLLQRAARLGYKDVVLYCLQKHSEDVNHRDNAGYTALHEACSRGWTDILNILLQHG---ANVNCSSQ--DG 1568
Cdd:cd22192     10 LLQQKRISESPLLLAAKENDVQAIKKLLKCPSCDLFQRGALGETALHVAALYDNLEAAVVLMEAApelVNEPMTSDlyQG 89
                           90       100
                   ....*....|....*....|....*
gi 1958807188 1569 TRPVHDAVVNDNLETIWLLLSYGAD 1593
Cdd:cd22192     90 ETALHIAVVNQNLNLVRELIARGAD 114
 
Name Accession Description Interval E-value
PUFD_like_1 cd14260
PCGF Ub-like fold discriminator of BCOR-like 1; The PUFD domain binds the RAWUL (RING finger ...
1669-1782 1.05e-65

PCGF Ub-like fold discriminator of BCOR-like 1; The PUFD domain binds the RAWUL (RING finger and WD40-associated ubiquitin-like) domain of the polycomb-group RING finger homologs PCGF1 and PCGF3. PUFD was characterized as a domain of the BCL6 corepressor BCOR. It does not appear to bind to PCGF2 and PCGF4. PCGF1 is a component of the Polycomb group (PcG) multi-protein BCOR complex, which is involved in repressing the transcription of BCL6 and CDKN1A. The BCL-6 corepressor-like protein 1 (BCoR-L1) is largely uncharacterized; it contains ankyrin repeats.


Pssm-ID: 271223  Cd Length: 115  Bit Score: 217.79  E-value: 1.05e-65
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188 1669 EQDDFMFELSDKPLLPCYNLQVSVSRGPCNWFLFSDVLKRLKLSSRIFQARFPHLEITTLPKAEFYRQVASSQLLTPAER 1748
Cdd:cd14260      2 EEDDFMFEFSDKPLLPCYNLQVSVSRGPCNWFLFSDVLKRLKLSSRIFQARFPHFEIATMPKAEFYRQVLSSQLLTPAER 81
                           90       100       110
                   ....*....|....*....|....*....|....
gi 1958807188 1749 PGSLEDRSPPGSSETVELVQYEPELLRLLGSEVE 1782
Cdd:cd14260     82 PGGLDDRSPQGSSETVELVRYEPELLRLLGSAVE 115
PUFD pfam16553
BCORL-PCGF1-binding domain; PUFD is the minimal domain at the C-terminus of BCORL (BCL6 ...
1671-1787 1.13e-61

BCORL-PCGF1-binding domain; PUFD is the minimal domain at the C-terminus of BCORL (BCL6 corepressor) that is needed for binding and giving specificity to some of the PCGF proteins, polycomb-group RING finger homologs. PUFD binds to the RAWUL (RING finger- and WD40-associated ubiquitin-like) domain of the particular PCGF PCGF1, pfam16207. Polycomb group proteins form repressive complexes (PRC) that mediate epigenetic modifications of histones. In humans there are many different PCGF homologs whose functions all vary, but the direct binding partner of PCGF1 is BCOR. BCOR has emerged as an important player in development and health.


Pssm-ID: 465171  Cd Length: 114  Bit Score: 206.08  E-value: 1.13e-61
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188 1671 DDFMFELSDKPLLPCYNLQVSVSRGPCNWFLFSDVLKRLKLSSRIFQARFPHLEITTLPKAEFYRQVASSQLLTPAERPG 1750
Cdd:pfam16553    2 DVFEFEFSDKPLLPCYNIQVSLSQGPRNWLLLSDVLKRLKMSSRIFRARFPHFEVVTIAEAEFYKQVSLSQLLSPPEDLE 81
                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 1958807188 1751 SledrSPPGSSETVELVQYEPELLRLLGSEVEYQSWS 1787
Cdd:pfam16553   82 A----FNPDSKELVELVEFTPELQTLLGSSVEFLHPS 114
PUFD_like cd14259
PCGF Ub-like fold discriminator and related domains; The PUFD domain binds the RAWUL (RING ...
1671-1782 2.17e-42

PCGF Ub-like fold discriminator and related domains; The PUFD domain binds the RAWUL (RING finger and WD40-associated ubiquitin-like) domain of the polycomb-group RING finger homologs PCGF1 and PCGF3. PUFD was characterized as a domain of the BCL6 corepressor BCOR. It does not appear to bind to PCGF2 and PCGF4. PCGF1 is a component of the Polycomb group (PcG) multi-protein BCOR complex, which is involved in repressing the transcription of BCL6 and CDKN1A. The BCL-6 corepressor (BCOR) is a transcriptional repressor required for germinal center formation and is possibly involved in apoptosis.


Pssm-ID: 271222  Cd Length: 106  Bit Score: 150.54  E-value: 2.17e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188 1671 DDFMFELSDKPLLPCYNLQVSVSRGPCNWFLFSDVLKRLKLSSRIFQARFPHLEITTLPKAEFYRQVASSQLLTPAERPg 1750
Cdd:cd14259      1 DDFEFEFSDEPLPPLYNLRISPNDGPRNWHLLSDVLTRLKLKSRDFLLKQICLELTSIPIEDFLEQASCLQLLCAGEKL- 79
                           90       100       110
                   ....*....|....*....|....*....|..
gi 1958807188 1751 sledrSPPGSSETVELVQYEPELLRLLGSEVE 1782
Cdd:cd14259     80 -----TNNVSSSKVELVEYNDSLRSLLGIEVE 106
PUFD cd14261
PCGF Ub-like fold discriminator of BCOR; The PUFD domain binds the RAWUL (RING finger and ...
1666-1783 7.67e-39

PCGF Ub-like fold discriminator of BCOR; The PUFD domain binds the RAWUL (RING finger and WD40-associated ubiquitin-like) domain of the polycomb-group RING finger homologs PCGF1 and PCGF3. PUFD was characterized as a domain of the BCL6 corepressor BCOR. It does not appear to bind to PCGF2 and PCGF4. PCGF1 is a component of the Polycomb group (PcG) multi-protein BCOR complex, which is involved in repressing the transcription of BCL6 and CDKN1A. The BCL-6 corepressor (BCOR) is a transcriptional repressor required for germinal center formation and is possibly involved in apoptosis.


Pssm-ID: 271224  Cd Length: 117  Bit Score: 141.14  E-value: 7.67e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188 1666 DDSEQDDFMFELSDKPLLPCYNLQVSVSRGPCNWFLFSDVLKRLKLSSRIFQARFPHLEITTLPKAEFYRQVASSQLLTP 1745
Cdd:cd14261      1 DDAYSDVFEFEFSDRPLLPCYNIQVSLSQGPRNWLLLSDVLKRLKMSSRIFRCNFPNVEVVTIAEAEFYRQVSLSQLFSC 80
                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 1958807188 1746 AErpgSLEDRSPPgSSETVELVQYEPELLRLLGSEVEY 1783
Cdd:cd14261     81 PK---DLEAFNPD-SKELLDLVEFTNELQTLLGSSLEW 114
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1499-1615 1.36e-27

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 114.67  E-value: 1.36e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188 1499 NAGETLLQRAARLGYKDVVLYCLQKHSeDVNHRDNAGYTALHEACSRGWTDILNILLQHGANVNCSSQDGTRPVHDAVVN 1578
Cdd:COG0666    118 KDGETPLHLAAYNGNLEIVKLLLEAGA-DVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAEN 196
                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 1958807188 1579 DNLETIWLLLSYGADPTLATYSGQTAMKLASSDNMKR 1615
Cdd:COG0666    197 GHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLE 233
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1494-1612 2.35e-25

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 108.12  E-value: 2.35e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188 1494 LIVNKNAGETLLQRAARLGYKDVVLYCLqKHSEDVNHRDNAGYTALHEACSRGWTDILNILLQHGANVNCSSQDGTRPVH 1573
Cdd:COG0666     80 INAKDDGGNTLLHAAARNGDLEIVKLLL-EAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLH 158
                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 1958807188 1574 DAVVNDNLETIWLLLSYGADPTLATYSGQTAMKLASSDN 1612
Cdd:COG0666    159 LAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENG 197
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1489-1615 9.23e-20

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 91.94  E-value: 9.23e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188 1489 PEARRLIVNKNA--------GETLLQRAARLGYKDVVLYCLqKHSEDVNHRDNAGYTALHEACSRGWTDILNILLQHGAN 1560
Cdd:COG0666    133 LEIVKLLLEAGAdvnaqdndGNTPLHLAAANGNLEIVKLLL-EAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGAD 211
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1958807188 1561 VNCSSQDGTRPVHDAVVNDNLETIWLLLSYGADPTLATYSGQTAMKLASSDNMKR 1615
Cdd:COG0666    212 VNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAAL 266
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1494-1612 5.85e-17

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 83.46  E-value: 5.85e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188 1494 LIVNKNAGETLLQRAARLGYKDVVLYCLQKHSEDVNHRDNAGYTALHEACSRGWTDILNILLQHGANVNCSSQDGTRPVH 1573
Cdd:COG0666     46 ALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLH 125
                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 1958807188 1574 DAVVNDNLETIWLLLSYGADPTLATYSGQTAMKLASSDN 1612
Cdd:COG0666    126 LAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANG 164
Ank_2 pfam12796
Ankyrin repeats (3 copies);
1505-1596 1.04e-16

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 76.69  E-value: 1.04e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188 1505 LQRAARLGYKDVVLYCLQKHSeDVNHRDNAGYTALHEACSRGWTDILNILLQHgANVNCSSQDGTrPVHDAVVNDNLETI 1584
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGA-DANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKDNGRT-ALHYAARSGHLEIV 77
                           90
                   ....*....|..
gi 1958807188 1585 WLLLSYGADPTL 1596
Cdd:pfam12796   78 KLLLEKGADINV 89
PHA03247 PHA03247
large tegument protein UL36; Provisional
201-636 6.17e-14

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 78.06  E-value: 6.17e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188  201 APICPPAPGSASGTPSVPDPFQVPLSVPAPVPHSGLVPVQVATSASAPSPPLAPVPALAPAAPSVPTLISDSNPLSVSAS 280
Cdd:PHA03247  2600 APVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSP 2679
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188  281 VLVPVPVSAPhsvpvplsaPAPTPLTVSVSAPPlaliQAPVPPSAPTLVLASVPTPvlapmpastppaapappsvpmPTP 360
Cdd:PHA03247  2680 PQRPRRRAAR---------PTVGSLTSLADPPP----PPPTPEPAPHALVSATPLP---------------------PGP 2725
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188  361 TPSSGPPSTPTLIPAFAPTPVPAPTPAPIFTPAPTPMPAATPAAIPTSAPI-----------PASFSLSRVCFPAAQAPA 429
Cdd:PHA03247  2726 AAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAagpprrltrpaVASLSESRESLPSPWDPA 2805
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188  430 MQKVPLSFQPGTVLTPNQPLVYIPPPSCGQPLSVATLPTTLGVSSTLTLPVLPsylqdrclpgvlASPELRSYPYAFSVA 509
Cdd:PHA03247  2806 DPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAP------------GGDVRRRPPSRSPAA 2873
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188  510 RPLASDSKLVSlevnRLSCTSPSSSTNSQPAPEGVPGP-----LADTSLTTASAKVLPTSQPLLPAPSGSSVPLHPSKMP 584
Cdd:PHA03247  2874 KPAAPARPPVR----RLARPAVSRSTESFALPPDQPERppqpqAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDP 2949
                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1958807188  585 GGTDQQTEGTSVTFSPLKSPPQLE--REMASPPECSeMPLDLSSKSNRQKLPLP 636
Cdd:PHA03247  2950 AGAGEPSGAVPQPWLGALVPGRVAvpRFRVPQPAPS-REAPASSTPPLTGHSLS 3002
PHA03247 PHA03247
large tegument protein UL36; Provisional
66-544 7.81e-12

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 71.12  E-value: 7.81e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188   66 GSGSNARGTNPDGSTTEKLGHRSEDQPDDPQakmdyvgntaeaeGLLVPLSSPGDSLKLPTPDGTEASHSRANCSWTPLS 145
Cdd:PHA03247  2579 EPAVTSRARRPDAPPQSARPRAPVDDRGDPR-------------GPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPT 2645
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188  146 TQMSKQVDCSPAGvkaldSRHSVGEKNTFILATLGTGVPVEGTLPlvttnfsqlpaPICPPAPGSASGTPSVPDPFQVPL 225
Cdd:PHA03247  2646 VPPPERPRDDPAP-----GRVSRPRRARRLGRAAQASSPPQRPRR-----------RAARPTVGSLTSLADPPPPPPTPE 2709
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188  226 SVPAP-VPHSGLVPVQVATSASAPSPPlapvpalapaapsvptliSDSNPLSVSASVLVPVPVSAPHSVPVPLSAPAPTP 304
Cdd:PHA03247  2710 PAPHAlVSATPLPPGPAAARQASPALP------------------AAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAP 2771
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188  305 LTVSVSAPPLALIQAPVPPSAPTLvlASVPTPvlapmpastpPAAPAPPSVPMPTPTPSSGPPSTPTLIPAFAPTPVPAP 384
Cdd:PHA03247  2772 PAAPAAGPPRRLTRPAVASLSESR--ESLPSP----------WDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAP 2839
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188  385 TPAPIFTPAPTPM--------------PAATPAAIPTSAPIP-----ASFSLSRVCFPAAQAPAMQKVPLSFQPGTVLTP 445
Cdd:PHA03247  2840 PPPPGPPPPSLPLggsvapggdvrrrpPSRSPAAKPAAPARPpvrrlARPAVSRSTESFALPPDQPERPPQPQAPPPPQP 2919
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188  446 N-----QPLVYIPPPSCGQPLSVATlPTTLGVSSTLTLPVLPSYLQDRCLPGVLASPELRSYPYAFSVARPLASDSKLVS 520
Cdd:PHA03247  2920 QpqpppPPQPQPPPPPPPRPQPPLA-PTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPASSTPPLTG 2998
                          490       500
                   ....*....|....*....|....
gi 1958807188  521 LEVNRLSCTSPSSSTNSQPAPEGV 544
Cdd:PHA03247  2999 HSLSRVSSWASSLALHEETDPPPV 3022
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1499-1605 1.23e-11

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 67.67  E-value: 1.23e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188 1499 NAGETLLQRAARLGYKDVVLYcLQKHSEDVNHRDNAGYTALHEACSRGWTDILNILLQHGANVNCSSQDGTRPVHDAVVN 1578
Cdd:COG0666    184 NDGETPLHLAAENGHLEIVKL-LLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAA 262
                           90       100
                   ....*....|....*....|....*..
gi 1958807188 1579 DNLETIWLLLSYGADPTLATYSGQTAM 1605
Cdd:COG0666    263 GAALIVKLLLLALLLLAAALLDLLTLL 289
PHA03100 PHA03100
ankyrin repeat protein; Provisional
1502-1593 3.16e-10

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 64.30  E-value: 3.16e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188 1502 ETLLQRAARLGYKDVVLYCLqKHSEDVNHRDNAGYTALHEACSRGWTDILNILLQHGANVNCSSQDGTRPVHDAVVNDNL 1581
Cdd:PHA03100   160 KLLIDKGVDINAKNRVNYLL-SYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNK 238
                           90
                   ....*....|..
gi 1958807188 1582 ETIWLLLSYGAD 1593
Cdd:PHA03100   239 EIFKLLLNNGPS 250
Ank_2 pfam12796
Ankyrin repeats (3 copies);
1496-1562 7.61e-10

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 57.43  E-value: 7.61e-10
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958807188 1496 VNKNAGETLLQRAARLGYKDVVLYCLQKhsEDVNHRDNaGYTALHEACSRGWTDILNILLQHGANVN 1562
Cdd:pfam12796   25 LQDKNGRTALHLAAKNGHLEIVKLLLEH--ADVNLKDN-GRTALHYAARSGHLEIVKLLLEKGADIN 88
Ank_2 pfam12796
Ankyrin repeats (3 copies);
1539-1624 4.81e-09

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 55.12  E-value: 4.81e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188 1539 LHEACSRGWTDILNILLQHGANVNCSSQDGTRPVHDAVVNDNLETIWLLLSYGAdpTLATYSGQTAMKLASSDNMK---R 1615
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHAD--VNLKDNGRTALHYAARSGHLeivK 78

                   ....*....
gi 1958807188 1616 FLSDHLSDL 1624
Cdd:pfam12796   79 LLLEKGADI 87
PHA03100 PHA03100
ankyrin repeat protein; Provisional
1489-1622 8.14e-09

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 60.06  E-value: 8.14e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188 1489 PEARRLIVNKNA--------GETLLQRAA--RLGYKDVVLYCLQKHSeDVNHRDNAGYTALHEA--CSRGWTDILNILLQ 1556
Cdd:PHA03100    86 KEIVKLLLEYGAnvnapdnnGITPLLYAIskKSNSYSIVEYLLDNGA-NVNIKNSDGENLLHLYleSNKIDLKILKLLID 164
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188 1557 HGANVN-CSSQD---------------GTRPVHDAVVNDNLETIWLLLSYGADPTLATYSGQTAMKLASSDNMKRFLSDH 1620
Cdd:PHA03100   165 KGVDINaKNRVNyllsygvpinikdvyGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLL 244

                   ..
gi 1958807188 1621 LS 1622
Cdd:PHA03100   245 LN 246
PHA02876 PHA02876
ankyrin repeat protein; Provisional
1470-1593 2.23e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 55.84  E-value: 2.23e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188 1470 YRSAGSEETSESPTARQIPPEARRLIVNKNA----GETLLQRAARLGYKDVVLYCLQKHSEDVNHRDNAGYTALHEACSR 1545
Cdd:PHA02876   272 CKNTPLHHASQAPSLSRLVPKLLERGADVNAknikGETPLYLMAKNGYDTENIRTLIMLGADVNAADRLYITPLHQASTL 351
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 1958807188 1546 G-WTDILNILLQHGANVNCSSQDGTRPVHDAVVNDNLETIWLLLSYGAD 1593
Cdd:PHA02876   352 DrNKDIVITLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGAD 400
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1490-1612 2.67e-07

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 54.19  E-value: 2.67e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188 1490 EARRLIVNKNAGETLLQRAARLGYKDVVLYCLQKHSEDVNHRDNAGYTALHEACSRGWTDILNILLQHGANVNCSSQDGT 1569
Cdd:COG0666      9 LLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGN 88
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 1958807188 1570 RPVHDAVVNDNLETIWLLLSYGADPTLATYSGQTAMKLASSDN 1612
Cdd:COG0666     89 TLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNG 131
Ank_4 pfam13637
Ankyrin repeats (many copies);
1535-1587 3.64e-07

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 48.42  E-value: 3.64e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1958807188 1535 GYTALHEACSRGWTDILNILLQHGANVNCSSQDGTRPVHDAVVNDNLETI-WLL 1587
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLkLLL 54
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
1553-1637 4.08e-07

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 54.90  E-value: 4.08e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188 1553 ILLQHGANVNCSSQDGTRPVHDAVVNDNLETIWLLLSYGADPTLATYSGQTAMKLASSDNMKRFLSDHLSDLQGRAEGDP 1632
Cdd:PTZ00322   100 ILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRHSQCHFELGA 179

                   ....*
gi 1958807188 1633 RASWD 1637
Cdd:PTZ00322   180 NAKPD 184
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
218-664 7.02e-07

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 54.39  E-value: 7.02e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188  218 PDPFQVPLSVPAPVPHSGLVPVQVATSASAPSPPLAPVPALAPAAPSVPTLISDSNPLSV--SASVLVPVPVSAPHSVPV 295
Cdd:pfam03154  171 PPVLQAQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPHTLiqQTPTLHPQRLPSPHPPLQ 250
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188  296 PLSAPAPtPLTVSVSAPPLALIQAPVPP------SAPTLVLASVPTpvlapMPASTPPAAPAPPSVPMPTPTPSSGPPST 369
Cdd:pfam03154  251 PMTQPPP-PSQVSPQPLPQPSLHGQMPPmphslqTGPSHMQHPVPP-----QPFPLTPQSSQSQVPPGPSPAAPGQSQQR 324
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188  370 PTLIPAFAPTPVPAPTPAPIFTPAPTPMPAATPaaiPTSAPIPAsfslsrvcFPAAQA---PAMQKVPLSFQPGTVLtpn 446
Cdd:pfam03154  325 IHTPPSQSQLQSQQPPREQPLPPAPLSMPHIKP---PPTTPIPQ--------LPNPQShkhPPHLSGPSPFQMNSNL--- 390
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188  447 qplvyiPPPSCGQPLSvaTLPTTLGVSStlTLPVLPSYLQDRCLPGVLASPelrsypyafsvarPLASDSKLVSLEVNRL 526
Cdd:pfam03154  391 ------PPPPALKPLS--SLSTHHPPSA--HPPPLQLMPQSQQLPPPPAQP-------------PVLTQSQSLPPPAASH 447
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188  527 SCTSPSSSTNSQP-------APEGVPGPLADTSLTTASAKVLPTSQPLLPAPSGSSVPLhpskmPGGTDQQTEGTSVTFS 599
Cdd:pfam03154  448 PPTSGLHQVPSQSpfpqhpfVPGGPPPITPPSGPPTSTSSAMPGIQPPSSASVSSSGPV-----PAAVSCPLPPVQIKEE 522
                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958807188  600 PLKSPPQLEremaSPPecsempldlssksnrqklPLPNQRKTPPMPVLTPVHTSSKALLSTVLSR 664
Cdd:pfam03154  523 ALDEAEEPE----SPP------------------PPPRSPSPEPTVVNTPSHASQSARFYKHLDR 565
PHA03095 PHA03095
ankyrin-like protein; Provisional
1521-1604 1.31e-06

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 53.10  E-value: 1.31e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188 1521 LQKHSEDVNHRDNAGYTALHeACSRGW---TDILNILLQHGANVNCSSQDGTRPVHDAVVNDN--LETIWLLLSYGADPT 1595
Cdd:PHA03095   103 LIKAGADVNAKDKVGRTPLH-VYLSGFninPKVIRLLLRKGADVNALDLYGMTPLAVLLKSRNanVELLRLLIDAGADVY 181

                   ....*....
gi 1958807188 1596 LATYSGQTA 1604
Cdd:PHA03095   182 AVDDRFRSL 190
Ank_4 pfam13637
Ankyrin repeats (many copies);
1503-1555 1.82e-06

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 46.50  E-value: 1.82e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1958807188 1503 TLLQRAARLGYKDVVLYCLQkHSEDVNHRDNAGYTALHEACSRGWTDILNILL 1555
Cdd:pfam13637    3 TALHAAAASGHLELLRLLLE-KGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA02874 PHA02874
ankyrin repeat protein; Provisional
1527-1605 3.63e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 51.50  E-value: 3.63e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958807188 1527 DVNHRDNAGYTALHEACSRGWTDILNILLQHGANVNCSSQDGTRPVHDAVVNDNLETIWLLLSYGADPTLATYSGQTAM 1605
Cdd:PHA02874   116 DVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPL 194
PHA02878 PHA02878
ankyrin repeat protein; Provisional
1513-1608 3.88e-06

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 51.42  E-value: 3.88e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188 1513 YKDVVLYCLQKHSEDVNHRDNAGYTALHEACSRGWT-DILNILLQHGANVNC-SSQDGTRPVHDAVVNDnlETIWLLLSY 1590
Cdd:PHA02878   212 YNKPIVHILLENGASTDARDKCGNTPLHISVGYCKDyDILKLLLEHGVDVNAkSYILGLTALHSSIKSE--RKLKLLLEY 289
                           90
                   ....*....|....*...
gi 1958807188 1591 GADPTLATYSGQTAMKLA 1608
Cdd:PHA02878   290 GADINSLNSYKLTPLSSA 307
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
1535-1563 5.90e-06

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 44.50  E-value: 5.90e-06
                            10        20
                    ....*....|....*....|....*....
gi 1958807188  1535 GYTALHEACSRGWTDILNILLQHGANVNC 1563
Cdd:smart00248    2 GRTPLHLAAENGNLEVVKLLLDKGADINA 30
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
208-419 1.17e-05

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 50.26  E-value: 1.17e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188  208 PGSASGTPSVPDPFQVPLSVPAPVPHSGLVPVQVATSASAPSPPLAPVPALAPAAPSVPTLIS---DSNPLSVSASVLVP 284
Cdd:PRK12323   365 PGQSGGGAGPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSpapEALAAARQASARGP 444
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188  285 VPVSAPHSVPVPLSAPAPTPLTVSVSAPPLALIQAPVPPsaptlvlASVPTPVLAPMPASTPPAAPAPPSVPMPTPTPSS 364
Cdd:PRK12323   445 GGAPAPAPAPAAAPAAAARPAAAGPRPVAAAAAAAPARA-------APAAAPAPADDDPPPWEELPPEFASPAPAQPDAA 517
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1958807188  365 GPPSTPTLIPAFAPTPVPAPTPAPIFTPAPTPMPAATPAAIPTSAPIPASFSLSR 419
Cdd:PRK12323   518 PAGWVAESIPDPATADPDDAFETLAPAPAAAPAPRAAAATEPVVAPRPPRASASG 572
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
1501-1617 1.44e-05

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 50.25  E-value: 1.44e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188 1501 GETLLQRAARLGYKDVVLYCLqKHSEDVNHRDNAGYTALHEACSRGWTDILNILLQHGANVNcsSQDGTRPVHDAVVNDN 1580
Cdd:PLN03192   558 GRTPLHIAASKGYEDCVLVLL-KHACNVHIRDANGNTALWNAISAKHHKIFRILYHFASISD--PHAAGDLLCTAAKRND 634
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 1958807188 1581 LETIWLLLSYGADPTLATYSGQTAMKLASSD---NMKRFL 1617
Cdd:PLN03192   635 LTAMKELLKQGLNVDSEDHQGATALQVAMAEdhvDMVRLL 674
PHA03100 PHA03100
ankyrin repeat protein; Provisional
1536-1624 1.74e-05

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 49.28  E-value: 1.74e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188 1536 YTALHEACSRGWTDILNILLQHGANVNCSSQDGTRPVH-----DAVVNDNLETIWLLLSYGADPTLATYSGQT-----AM 1605
Cdd:PHA03100    36 VLPLYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHylsniKYNLTDVKEIVKLLLEYGANVNAPDNNGITpllyaIS 115
                           90
                   ....*....|....*....
gi 1958807188 1606 KLASSDNMKRFLSDHLSDL 1624
Cdd:PHA03100   116 KKSNSYSIVEYLLDNGANV 134
PHA02878 PHA02878
ankyrin repeat protein; Provisional
1521-1610 2.02e-05

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 49.11  E-value: 2.02e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188 1521 LQKHSEDVNHRD-NAGYTALHEACSRGWTDILNILLQHGANVNCSSQDGTRPVHDAVVNDNLETIWLLLSYGADPTLATY 1599
Cdd:PHA02878   153 LLSYGADINMKDrHKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDK 232
                           90
                   ....*....|.
gi 1958807188 1600 SGQTAMKLASS 1610
Cdd:PHA02878   233 CGNTPLHISVG 243
PHA03095 PHA03095
ankyrin-like protein; Provisional
1527-1593 2.03e-05

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 49.25  E-value: 2.03e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958807188 1527 DVNHRDNAGYTALHEACSRGW---TDILNILLQHGANVNCSSQDGTRPVHDAVVNDN-LETIWLLLSYGAD 1593
Cdd:PHA03095    39 DVNFRGEYGKTPLHLYLHYSSekvKDIVRLLLEAGADVNAPERCGFTPLHLYLYNATtLDVIKLLIKAGAD 109
PHA03247 PHA03247
large tegument protein UL36; Provisional
215-649 2.14e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 49.94  E-value: 2.14e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188  215 PSVPDPFQVPLSVPAPVPHSGLVP-VQVATSASAPSPPLAPVPALAPAAPSVPTLISDSnplsvSASVLVPVPVSAPHSV 293
Cdd:PHA03247  2489 PFAAGAAPDPGGGGPPDPDAPPAPsRLAPAILPDEPVGEPVHPRMLTWIRGLEELASDD-----AGDPPPPLPPAAPPAA 2563
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188  294 P---VPLSAPAPTPLTVSV-------SAPPL-ALIQAPV-PPSAPTLVLASVPTPVLAPMPASTPPAAPAPPSVPMPTPT 361
Cdd:PHA03247  2564 PdrsVPPPRPAPRPSEPAVtsrarrpDAPPQsARPRAPVdDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPP 2643
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188  362 PSSGPPSTPTLIPAfaptPVPAPTPAPIFTPAPTPMPAATPAAIPTSAPIPASFSLSRVCFPAAQAPAMQKVPLSFQPGT 441
Cdd:PHA03247  2644 PTVPPPERPRDDPA----PGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSAT 2719
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188  442 VLTPNQPLVYIPPPScgQPLSVATLPTTLGvsstltlPVLPSYLQDRCLPGVLASPELRSYPyafsVARPLASDSKLVSL 521
Cdd:PHA03247  2720 PLPPGPAAARQASPA--LPAAPAPPAVPAG-------PATPGGPARPARPPTTAGPPAPAPP----AAPAAGPPRRLTRP 2786
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188  522 EVNRLSCTSPSSSTNSQPAPEGVPGPLADTSLTTASA---------KVLPTSQPLLPAPSGSSVPLHPSKMPGG--TDQQ 590
Cdd:PHA03247  2787 AVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASpagplppptSAQPTAPPPPPGPPPPSLPLGGSVAPGGdvRRRP 2866
                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188  591 TEGTSVTFSPLKSPPQLEREMASPPECSEMPLDLSSKS-NRQKLPLPNQRKTPPMPVLTP 649
Cdd:PHA03247  2867 PSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQpERPPQPQAPPPPQPQPQPPPP 2926
Ank_5 pfam13857
Ankyrin repeats (many copies);
1521-1573 3.30e-05

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 43.10  E-value: 3.30e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1958807188 1521 LQKHSEDVNHRDNAGYTALHEACSRGWTDILNILLQHGANVNCSSQDGTRPVH 1573
Cdd:pfam13857    2 LEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALD 54
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
1535-1563 4.13e-05

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 42.28  E-value: 4.13e-05
                           10        20        30
                   ....*....|....*....|....*....|
gi 1958807188 1535 GYTALHEACSR-GWTDILNILLQHGANVNC 1563
Cdd:pfam00023    2 GNTPLHLAAGRrGNLEIVKLLLSKGADVNA 31
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
1527-1590 1.22e-04

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 46.82  E-value: 1.22e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958807188 1527 DVNHRDNAGYTALHEACSRGWTDILNILLQHGANVNCSSQDGTRPVHDAVVNDNLETIWLLLSY 1590
Cdd:PTZ00322   107 DPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRH 170
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
1535-1563 1.46e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 40.32  E-value: 1.46e-04
                           10        20
                   ....*....|....*....|....*....
gi 1958807188 1535 GYTALHEACSRGWTDILNILLQHGANVNC 1563
Cdd:pfam13606    2 GNTPLHLAARNGRLEIVKLLLENGADINA 30
PHA02876 PHA02876
ankyrin repeat protein; Provisional
1521-1584 2.94e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 45.82  E-value: 2.94e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958807188 1521 LQKHSEDVNHRDNAGYTALHEACSRGWTDILNILLQHGANVNCSSQDGTRPVHDAVVNDNLETI 1584
Cdd:PHA02876   164 LLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTI 227
PHA03100 PHA03100
ankyrin repeat protein; Provisional
1495-1562 3.32e-04

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 45.04  E-value: 3.32e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958807188 1495 IVNKNA-GETLLQRAARLGYKDVVLYCLQKhSEDVNHRDNAGYTALHEACSRGWTDILNILLQHGANVN 1562
Cdd:PHA03100   185 INIKDVyGFTPLHYAVYNNNPEFVKYLLDL-GANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPSIK 252
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
1521-1617 4.15e-04

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 45.24  E-value: 4.15e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188 1521 LQKHSEDVNHRDNAGYTALHEACSRGWTDILNILLQHGANVNCSSQDGTRPVHDAVVNDNLETIWLLLSYGA--DPTLAT 1598
Cdd:PLN03192   544 LLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHKIFRILYHFASisDPHAAG 623
                           90
                   ....*....|....*....
gi 1958807188 1599 YSGQTAMKLASSDNMKRFL 1617
Cdd:PLN03192   624 DLLCTAAKRNDLTAMKELL 642
PHA02874 PHA02874
ankyrin repeat protein; Provisional
1502-1608 5.25e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 44.57  E-value: 5.25e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188 1502 ETLLQRAARLGYKDVVlYCLQKHSEDVNHRDNAGYTALHEACSRGWTDILNILLQHGANVNCSSQDGTRPVHDAVVNDNL 1581
Cdd:PHA02874   125 KTFLHYAIKKGDLESI-KMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDY 203
                           90       100
                   ....*....|....*....|....*..
gi 1958807188 1582 ETIWLLLSYGADPTLATYSGQTAMKLA 1608
Cdd:PHA02874   204 ACIKLLIDHGNHIMNKCKNGFTPLHNA 230
PHA03095 PHA03095
ankyrin-like protein; Provisional
1513-1595 7.27e-04

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 44.25  E-value: 7.27e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188 1513 YKDVVLyCLQKHSEDVNHRDNAGYTALH-EACSRGWTDILNILLQHGANVNCSSQDGTRPVHD--AVVNDNLETIWLLLS 1589
Cdd:PHA03095    62 VKDIVR-LLLEAGADVNAPERCGFTPLHlYLYNATTLDVIKLLIKAGADVNAKDKVGRTPLHVylSGFNINPKVIRLLLR 140

                   ....*.
gi 1958807188 1590 YGADPT 1595
Cdd:PHA03095   141 KGADVN 146
PHA03095 PHA03095
ankyrin-like protein; Provisional
1521-1622 7.99e-04

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 44.25  E-value: 7.99e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188 1521 LQKHSEDVNHRDNAGYTALHEA---CSRGWTDILNiLLQHGANVNCSSQDGTRPVHDAVVNDNLETIWLLLSYGADPTLA 1597
Cdd:PHA03095   208 LIRAGCDPAATDMLGNTPLHSMatgSSCKRSLVLP-LLIAGISINARNRYGQTPLHYAAVFNNPRACRRLIALGADINAV 286
                           90       100
                   ....*....|....*....|....*....
gi 1958807188 1598 TYSGQTAMKLASSDN----MKRFLSDHLS 1622
Cdd:PHA03095   287 SSDGNTPLSLMVRNNngraVRAALAKNPS 315
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
1494-1593 8.20e-04

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 44.23  E-value: 8.20e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188 1494 LIVNKNAGETLLQRAARLGYKDVVLYCLQKHSEDVNHRDNAGYTALHEACSRGWTDILNILLQHG---ANVNCSSQ--DG 1568
Cdd:cd22192     10 LLQQKRISESPLLLAAKENDVQAIKKLLKCPSCDLFQRGALGETALHVAALYDNLEAAVVLMEAApelVNEPMTSDlyQG 89
                           90       100
                   ....*....|....*....|....*
gi 1958807188 1569 TRPVHDAVVNDNLETIWLLLSYGAD 1593
Cdd:cd22192     90 ETALHIAVVNQNLNLVRELIARGAD 114
PHA02875 PHA02875
ankyrin repeat protein; Provisional
1521-1598 1.09e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 43.44  E-value: 1.09e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958807188 1521 LQKHSEDVNHRDNAGYTALHEACSRGWTDILNILLQHGANVNCSSQDG-TRPVHDAVVNDNLETIWLLLSYGADPTLAT 1598
Cdd:PHA02875   154 LIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANIDYFGKNGcVAALCYAIENNKIDIVRLFIKRGADCNIMF 232
PHA02875 PHA02875
ankyrin repeat protein; Provisional
1518-1610 1.16e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 43.44  E-value: 1.16e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188 1518 LYCLQKHSEDVNHRDnaGYTALHEACSRGWTDILNILLQHGANVNCSSQDGTRPVHDAVVNDNLETIWLLLSYGADPTLA 1597
Cdd:PHA02875    87 LLDLGKFADDVFYKD--GMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIE 164
                           90
                   ....*....|...
gi 1958807188 1598 TYSGQTAMKLASS 1610
Cdd:PHA02875   165 DCCGCTPLIIAMA 177
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
1495-1567 2.18e-03

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 42.93  E-value: 2.18e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958807188 1495 IVNKNAGETLLQRAARLGykDV-VLYCLQKHSEDVNHRDNAGYTALHEACSRGWTDILNILLQHGANVNCSSQD 1567
Cdd:PLN03192   616 ISDPHAAGDLLCTAAKRN--DLtAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGADVDKANTD 687
Ank_5 pfam13857
Ankyrin repeats (many copies);
1554-1608 2.92e-03

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 37.71  E-value: 2.92e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1958807188 1554 LLQHG-ANVNCSSQDGTRPVHDAVVNDNLETIWLLLSYGADPTLATYSGQTAMKLA 1608
Cdd:pfam13857    1 LLEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
PHA03269 PHA03269
envelope glycoprotein C; Provisional
175-336 3.77e-03

envelope glycoprotein C; Provisional


Pssm-ID: 165527 [Multi-domain]  Cd Length: 566  Bit Score: 42.02  E-value: 3.77e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188  175 ILATLGTGVPvegTLPLVTTNFSQLPapicPPAPGSASGTPSVPDPFQVPLSVPAPVPHSGLVPVQVATSASAPSpplap 254
Cdd:PHA03269    18 IIANLNTNIP---IPELHTSAATQKP----DPAPAPHQAASRAPDPAVAPTSAASRKPDLAQAPTPAASEKFDPA----- 85
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188  255 vpalapaapsvptlisdsnPLSVSASVLVPVPVSAPHSVpvplSAPAPTPLTVSVSAPPlaliQAPVPPSAPTLVLASVP 334
Cdd:PHA03269    86 -------------------PAPHQAASRAPDPAVAPQLA----AAPKPDAAEAFTSAAQ----AHEAPADAGTSAASKKP 138

                   ..
gi 1958807188  335 TP 336
Cdd:PHA03269   139 DP 140
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
311-569 7.75e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 41.01  E-value: 7.75e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188  311 APPLALIQAPVPPSAPTLVLASVPTPVLAPMPASTPPAAPAPPSVPMPTPTPSSGPPSTPTLIPAFAPTPVPaptpapif 390
Cdd:PRK12323   372 AGPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARG-------- 443
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188  391 tPAPTPMPAATPAAIPTSAPIPASFSLSRVCFPAAQAPAMQKVPLSFQPGTVLTPnqPLVYIPPpscgqplsvatlpttl 470
Cdd:PRK12323   444 -PGGAPAPAPAPAAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPP--PWEELPP---------------- 504
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188  471 gvsstlTLPVLPSYLQDRCLPGVLASPELRSYPYAFSVARPlasdsklvSLEVNRLSCTSPSSSTNSQPAPEGVPGPLAD 550
Cdd:PRK12323   505 ------EFASPAPAQPDAAPAGWVAESIPDPATADPDDAFE--------TLAPAPAAAPAPRAAAATEPVVAPRPPRASA 570
                          250
                   ....*....|....*....
gi 1958807188  551 TSLTTASAKVLPTSQPLLP 569
Cdd:PRK12323   571 SGLPDMFDGDWPALAARLP 589
PHA02876 PHA02876
ankyrin repeat protein; Provisional
1550-1612 8.94e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 40.82  E-value: 8.94e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958807188 1550 ILNILLQHGANVNCSSQDGTRPVHDAVVNDNLETIWLLLSYGADPTLATYSGQTAMKLASSDN 1612
Cdd:PHA02876   160 IAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSK 222
PHA02795 PHA02795
ankyrin-like protein; Provisional
1526-1568 9.42e-03

ankyrin-like protein; Provisional


Pssm-ID: 165157 [Multi-domain]  Cd Length: 437  Bit Score: 40.36  E-value: 9.42e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1958807188 1526 EDVNHRDNAGYTALHEACSRGWTDILNILLQHGANVNCSSQDG 1568
Cdd:PHA02795   212 EDINQLDAGGRTLLYRAIYAGYIDLVSWLLENGANVNAVMSNG 254
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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