BCL-6 corepressor-like protein 1 isoform X1 [Rattus norvegicus]
List of domain hits
Name | Accession | Description | Interval | E-value | |||||||
PUFD_like_1 | cd14260 | PCGF Ub-like fold discriminator of BCOR-like 1; The PUFD domain binds the RAWUL (RING finger ... |
1669-1782 | 1.05e-65 | |||||||
PCGF Ub-like fold discriminator of BCOR-like 1; The PUFD domain binds the RAWUL (RING finger and WD40-associated ubiquitin-like) domain of the polycomb-group RING finger homologs PCGF1 and PCGF3. PUFD was characterized as a domain of the BCL6 corepressor BCOR. It does not appear to bind to PCGF2 and PCGF4. PCGF1 is a component of the Polycomb group (PcG) multi-protein BCOR complex, which is involved in repressing the transcription of BCL6 and CDKN1A. The BCL-6 corepressor-like protein 1 (BCoR-L1) is largely uncharacterized; it contains ankyrin repeats. : Pssm-ID: 271223 Cd Length: 115 Bit Score: 217.79 E-value: 1.05e-65
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ANKYR | COG0666 | Ankyrin repeat [Signal transduction mechanisms]; |
1499-1615 | 1.36e-27 | |||||||
Ankyrin repeat [Signal transduction mechanisms]; : Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 114.67 E-value: 1.36e-27
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PHA03247 super family | cl33720 | large tegument protein UL36; Provisional |
201-636 | 6.17e-14 | |||||||
large tegument protein UL36; Provisional The actual alignment was detected with superfamily member PHA03247: Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 78.06 E-value: 6.17e-14
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Name | Accession | Description | Interval | E-value | |||||||
PUFD_like_1 | cd14260 | PCGF Ub-like fold discriminator of BCOR-like 1; The PUFD domain binds the RAWUL (RING finger ... |
1669-1782 | 1.05e-65 | |||||||
PCGF Ub-like fold discriminator of BCOR-like 1; The PUFD domain binds the RAWUL (RING finger and WD40-associated ubiquitin-like) domain of the polycomb-group RING finger homologs PCGF1 and PCGF3. PUFD was characterized as a domain of the BCL6 corepressor BCOR. It does not appear to bind to PCGF2 and PCGF4. PCGF1 is a component of the Polycomb group (PcG) multi-protein BCOR complex, which is involved in repressing the transcription of BCL6 and CDKN1A. The BCL-6 corepressor-like protein 1 (BCoR-L1) is largely uncharacterized; it contains ankyrin repeats. Pssm-ID: 271223 Cd Length: 115 Bit Score: 217.79 E-value: 1.05e-65
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PUFD | pfam16553 | BCORL-PCGF1-binding domain; PUFD is the minimal domain at the C-terminus of BCORL (BCL6 ... |
1671-1787 | 1.13e-61 | |||||||
BCORL-PCGF1-binding domain; PUFD is the minimal domain at the C-terminus of BCORL (BCL6 corepressor) that is needed for binding and giving specificity to some of the PCGF proteins, polycomb-group RING finger homologs. PUFD binds to the RAWUL (RING finger- and WD40-associated ubiquitin-like) domain of the particular PCGF PCGF1, pfam16207. Polycomb group proteins form repressive complexes (PRC) that mediate epigenetic modifications of histones. In humans there are many different PCGF homologs whose functions all vary, but the direct binding partner of PCGF1 is BCOR. BCOR has emerged as an important player in development and health. Pssm-ID: 465171 Cd Length: 114 Bit Score: 206.08 E-value: 1.13e-61
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ANKYR | COG0666 | Ankyrin repeat [Signal transduction mechanisms]; |
1499-1615 | 1.36e-27 | |||||||
Ankyrin repeat [Signal transduction mechanisms]; Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 114.67 E-value: 1.36e-27
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Ank_2 | pfam12796 | Ankyrin repeats (3 copies); |
1505-1596 | 1.04e-16 | |||||||
Ankyrin repeats (3 copies); Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 76.69 E-value: 1.04e-16
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PHA03247 | PHA03247 | large tegument protein UL36; Provisional |
201-636 | 6.17e-14 | |||||||
large tegument protein UL36; Provisional Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 78.06 E-value: 6.17e-14
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PHA03100 | PHA03100 | ankyrin repeat protein; Provisional |
1502-1593 | 3.16e-10 | |||||||
ankyrin repeat protein; Provisional Pssm-ID: 222984 [Multi-domain] Cd Length: 422 Bit Score: 64.30 E-value: 3.16e-10
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Atrophin-1 | pfam03154 | Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
218-664 | 7.02e-07 | |||||||
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity. Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 54.39 E-value: 7.02e-07
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ANK | smart00248 | ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ... |
1535-1563 | 5.90e-06 | |||||||
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure. Pssm-ID: 197603 [Multi-domain] Cd Length: 30 Bit Score: 44.50 E-value: 5.90e-06
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TRPV5-6 | cd22192 | Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ... |
1494-1593 | 8.20e-04 | |||||||
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues. Pssm-ID: 411976 [Multi-domain] Cd Length: 609 Bit Score: 44.23 E-value: 8.20e-04
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Name | Accession | Description | Interval | E-value | ||||||||
PUFD_like_1 | cd14260 | PCGF Ub-like fold discriminator of BCOR-like 1; The PUFD domain binds the RAWUL (RING finger ... |
1669-1782 | 1.05e-65 | ||||||||
PCGF Ub-like fold discriminator of BCOR-like 1; The PUFD domain binds the RAWUL (RING finger and WD40-associated ubiquitin-like) domain of the polycomb-group RING finger homologs PCGF1 and PCGF3. PUFD was characterized as a domain of the BCL6 corepressor BCOR. It does not appear to bind to PCGF2 and PCGF4. PCGF1 is a component of the Polycomb group (PcG) multi-protein BCOR complex, which is involved in repressing the transcription of BCL6 and CDKN1A. The BCL-6 corepressor-like protein 1 (BCoR-L1) is largely uncharacterized; it contains ankyrin repeats. Pssm-ID: 271223 Cd Length: 115 Bit Score: 217.79 E-value: 1.05e-65
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PUFD | pfam16553 | BCORL-PCGF1-binding domain; PUFD is the minimal domain at the C-terminus of BCORL (BCL6 ... |
1671-1787 | 1.13e-61 | ||||||||
BCORL-PCGF1-binding domain; PUFD is the minimal domain at the C-terminus of BCORL (BCL6 corepressor) that is needed for binding and giving specificity to some of the PCGF proteins, polycomb-group RING finger homologs. PUFD binds to the RAWUL (RING finger- and WD40-associated ubiquitin-like) domain of the particular PCGF PCGF1, pfam16207. Polycomb group proteins form repressive complexes (PRC) that mediate epigenetic modifications of histones. In humans there are many different PCGF homologs whose functions all vary, but the direct binding partner of PCGF1 is BCOR. BCOR has emerged as an important player in development and health. Pssm-ID: 465171 Cd Length: 114 Bit Score: 206.08 E-value: 1.13e-61
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PUFD_like | cd14259 | PCGF Ub-like fold discriminator and related domains; The PUFD domain binds the RAWUL (RING ... |
1671-1782 | 2.17e-42 | ||||||||
PCGF Ub-like fold discriminator and related domains; The PUFD domain binds the RAWUL (RING finger and WD40-associated ubiquitin-like) domain of the polycomb-group RING finger homologs PCGF1 and PCGF3. PUFD was characterized as a domain of the BCL6 corepressor BCOR. It does not appear to bind to PCGF2 and PCGF4. PCGF1 is a component of the Polycomb group (PcG) multi-protein BCOR complex, which is involved in repressing the transcription of BCL6 and CDKN1A. The BCL-6 corepressor (BCOR) is a transcriptional repressor required for germinal center formation and is possibly involved in apoptosis. Pssm-ID: 271222 Cd Length: 106 Bit Score: 150.54 E-value: 2.17e-42
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PUFD | cd14261 | PCGF Ub-like fold discriminator of BCOR; The PUFD domain binds the RAWUL (RING finger and ... |
1666-1783 | 7.67e-39 | ||||||||
PCGF Ub-like fold discriminator of BCOR; The PUFD domain binds the RAWUL (RING finger and WD40-associated ubiquitin-like) domain of the polycomb-group RING finger homologs PCGF1 and PCGF3. PUFD was characterized as a domain of the BCL6 corepressor BCOR. It does not appear to bind to PCGF2 and PCGF4. PCGF1 is a component of the Polycomb group (PcG) multi-protein BCOR complex, which is involved in repressing the transcription of BCL6 and CDKN1A. The BCL-6 corepressor (BCOR) is a transcriptional repressor required for germinal center formation and is possibly involved in apoptosis. Pssm-ID: 271224 Cd Length: 117 Bit Score: 141.14 E-value: 7.67e-39
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ANKYR | COG0666 | Ankyrin repeat [Signal transduction mechanisms]; |
1499-1615 | 1.36e-27 | ||||||||
Ankyrin repeat [Signal transduction mechanisms]; Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 114.67 E-value: 1.36e-27
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ANKYR | COG0666 | Ankyrin repeat [Signal transduction mechanisms]; |
1494-1612 | 2.35e-25 | ||||||||
Ankyrin repeat [Signal transduction mechanisms]; Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 108.12 E-value: 2.35e-25
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ANKYR | COG0666 | Ankyrin repeat [Signal transduction mechanisms]; |
1489-1615 | 9.23e-20 | ||||||||
Ankyrin repeat [Signal transduction mechanisms]; Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 91.94 E-value: 9.23e-20
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ANKYR | COG0666 | Ankyrin repeat [Signal transduction mechanisms]; |
1494-1612 | 5.85e-17 | ||||||||
Ankyrin repeat [Signal transduction mechanisms]; Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 83.46 E-value: 5.85e-17
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Ank_2 | pfam12796 | Ankyrin repeats (3 copies); |
1505-1596 | 1.04e-16 | ||||||||
Ankyrin repeats (3 copies); Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 76.69 E-value: 1.04e-16
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PHA03247 | PHA03247 | large tegument protein UL36; Provisional |
201-636 | 6.17e-14 | ||||||||
large tegument protein UL36; Provisional Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 78.06 E-value: 6.17e-14
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PHA03247 | PHA03247 | large tegument protein UL36; Provisional |
66-544 | 7.81e-12 | ||||||||
large tegument protein UL36; Provisional Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 71.12 E-value: 7.81e-12
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ANKYR | COG0666 | Ankyrin repeat [Signal transduction mechanisms]; |
1499-1605 | 1.23e-11 | ||||||||
Ankyrin repeat [Signal transduction mechanisms]; Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 67.67 E-value: 1.23e-11
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PHA03100 | PHA03100 | ankyrin repeat protein; Provisional |
1502-1593 | 3.16e-10 | ||||||||
ankyrin repeat protein; Provisional Pssm-ID: 222984 [Multi-domain] Cd Length: 422 Bit Score: 64.30 E-value: 3.16e-10
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Ank_2 | pfam12796 | Ankyrin repeats (3 copies); |
1496-1562 | 7.61e-10 | ||||||||
Ankyrin repeats (3 copies); Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 57.43 E-value: 7.61e-10
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Ank_2 | pfam12796 | Ankyrin repeats (3 copies); |
1539-1624 | 4.81e-09 | ||||||||
Ankyrin repeats (3 copies); Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 55.12 E-value: 4.81e-09
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PHA03100 | PHA03100 | ankyrin repeat protein; Provisional |
1489-1622 | 8.14e-09 | ||||||||
ankyrin repeat protein; Provisional Pssm-ID: 222984 [Multi-domain] Cd Length: 422 Bit Score: 60.06 E-value: 8.14e-09
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PHA02876 | PHA02876 | ankyrin repeat protein; Provisional |
1470-1593 | 2.23e-07 | ||||||||
ankyrin repeat protein; Provisional Pssm-ID: 165207 [Multi-domain] Cd Length: 682 Bit Score: 55.84 E-value: 2.23e-07
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ANKYR | COG0666 | Ankyrin repeat [Signal transduction mechanisms]; |
1490-1612 | 2.67e-07 | ||||||||
Ankyrin repeat [Signal transduction mechanisms]; Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 54.19 E-value: 2.67e-07
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Ank_4 | pfam13637 | Ankyrin repeats (many copies); |
1535-1587 | 3.64e-07 | ||||||||
Ankyrin repeats (many copies); Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 48.42 E-value: 3.64e-07
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PTZ00322 | PTZ00322 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional |
1553-1637 | 4.08e-07 | ||||||||
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional Pssm-ID: 140343 [Multi-domain] Cd Length: 664 Bit Score: 54.90 E-value: 4.08e-07
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Atrophin-1 | pfam03154 | Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
218-664 | 7.02e-07 | ||||||||
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity. Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 54.39 E-value: 7.02e-07
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PHA03095 | PHA03095 | ankyrin-like protein; Provisional |
1521-1604 | 1.31e-06 | ||||||||
ankyrin-like protein; Provisional Pssm-ID: 222980 [Multi-domain] Cd Length: 471 Bit Score: 53.10 E-value: 1.31e-06
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Ank_4 | pfam13637 | Ankyrin repeats (many copies); |
1503-1555 | 1.82e-06 | ||||||||
Ankyrin repeats (many copies); Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 46.50 E-value: 1.82e-06
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PHA02874 | PHA02874 | ankyrin repeat protein; Provisional |
1527-1605 | 3.63e-06 | ||||||||
ankyrin repeat protein; Provisional Pssm-ID: 165205 [Multi-domain] Cd Length: 434 Bit Score: 51.50 E-value: 3.63e-06
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PHA02878 | PHA02878 | ankyrin repeat protein; Provisional |
1513-1608 | 3.88e-06 | ||||||||
ankyrin repeat protein; Provisional Pssm-ID: 222939 [Multi-domain] Cd Length: 477 Bit Score: 51.42 E-value: 3.88e-06
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ANK | smart00248 | ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ... |
1535-1563 | 5.90e-06 | ||||||||
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure. Pssm-ID: 197603 [Multi-domain] Cd Length: 30 Bit Score: 44.50 E-value: 5.90e-06
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PRK12323 | PRK12323 | DNA polymerase III subunit gamma/tau; |
208-419 | 1.17e-05 | ||||||||
DNA polymerase III subunit gamma/tau; Pssm-ID: 237057 [Multi-domain] Cd Length: 700 Bit Score: 50.26 E-value: 1.17e-05
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PLN03192 | PLN03192 | Voltage-dependent potassium channel; Provisional |
1501-1617 | 1.44e-05 | ||||||||
Voltage-dependent potassium channel; Provisional Pssm-ID: 215625 [Multi-domain] Cd Length: 823 Bit Score: 50.25 E-value: 1.44e-05
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PHA03100 | PHA03100 | ankyrin repeat protein; Provisional |
1536-1624 | 1.74e-05 | ||||||||
ankyrin repeat protein; Provisional Pssm-ID: 222984 [Multi-domain] Cd Length: 422 Bit Score: 49.28 E-value: 1.74e-05
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PHA02878 | PHA02878 | ankyrin repeat protein; Provisional |
1521-1610 | 2.02e-05 | ||||||||
ankyrin repeat protein; Provisional Pssm-ID: 222939 [Multi-domain] Cd Length: 477 Bit Score: 49.11 E-value: 2.02e-05
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PHA03095 | PHA03095 | ankyrin-like protein; Provisional |
1527-1593 | 2.03e-05 | ||||||||
ankyrin-like protein; Provisional Pssm-ID: 222980 [Multi-domain] Cd Length: 471 Bit Score: 49.25 E-value: 2.03e-05
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PHA03247 | PHA03247 | large tegument protein UL36; Provisional |
215-649 | 2.14e-05 | ||||||||
large tegument protein UL36; Provisional Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 49.94 E-value: 2.14e-05
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Ank_5 | pfam13857 | Ankyrin repeats (many copies); |
1521-1573 | 3.30e-05 | ||||||||
Ankyrin repeats (many copies); Pssm-ID: 433530 [Multi-domain] Cd Length: 56 Bit Score: 43.10 E-value: 3.30e-05
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Ank | pfam00023 | Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ... |
1535-1563 | 4.13e-05 | ||||||||
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity. Pssm-ID: 459634 [Multi-domain] Cd Length: 34 Bit Score: 42.28 E-value: 4.13e-05
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PTZ00322 | PTZ00322 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional |
1527-1590 | 1.22e-04 | ||||||||
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional Pssm-ID: 140343 [Multi-domain] Cd Length: 664 Bit Score: 46.82 E-value: 1.22e-04
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Ank_3 | pfam13606 | Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ... |
1535-1563 | 1.46e-04 | ||||||||
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Pssm-ID: 463933 [Multi-domain] Cd Length: 30 Bit Score: 40.32 E-value: 1.46e-04
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PHA02876 | PHA02876 | ankyrin repeat protein; Provisional |
1521-1584 | 2.94e-04 | ||||||||
ankyrin repeat protein; Provisional Pssm-ID: 165207 [Multi-domain] Cd Length: 682 Bit Score: 45.82 E-value: 2.94e-04
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PHA03100 | PHA03100 | ankyrin repeat protein; Provisional |
1495-1562 | 3.32e-04 | ||||||||
ankyrin repeat protein; Provisional Pssm-ID: 222984 [Multi-domain] Cd Length: 422 Bit Score: 45.04 E-value: 3.32e-04
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PLN03192 | PLN03192 | Voltage-dependent potassium channel; Provisional |
1521-1617 | 4.15e-04 | ||||||||
Voltage-dependent potassium channel; Provisional Pssm-ID: 215625 [Multi-domain] Cd Length: 823 Bit Score: 45.24 E-value: 4.15e-04
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PHA02874 | PHA02874 | ankyrin repeat protein; Provisional |
1502-1608 | 5.25e-04 | ||||||||
ankyrin repeat protein; Provisional Pssm-ID: 165205 [Multi-domain] Cd Length: 434 Bit Score: 44.57 E-value: 5.25e-04
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PHA03095 | PHA03095 | ankyrin-like protein; Provisional |
1513-1595 | 7.27e-04 | ||||||||
ankyrin-like protein; Provisional Pssm-ID: 222980 [Multi-domain] Cd Length: 471 Bit Score: 44.25 E-value: 7.27e-04
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PHA03095 | PHA03095 | ankyrin-like protein; Provisional |
1521-1622 | 7.99e-04 | ||||||||
ankyrin-like protein; Provisional Pssm-ID: 222980 [Multi-domain] Cd Length: 471 Bit Score: 44.25 E-value: 7.99e-04
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TRPV5-6 | cd22192 | Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ... |
1494-1593 | 8.20e-04 | ||||||||
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues. Pssm-ID: 411976 [Multi-domain] Cd Length: 609 Bit Score: 44.23 E-value: 8.20e-04
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PHA02875 | PHA02875 | ankyrin repeat protein; Provisional |
1521-1598 | 1.09e-03 | ||||||||
ankyrin repeat protein; Provisional Pssm-ID: 165206 [Multi-domain] Cd Length: 413 Bit Score: 43.44 E-value: 1.09e-03
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PHA02875 | PHA02875 | ankyrin repeat protein; Provisional |
1518-1610 | 1.16e-03 | ||||||||
ankyrin repeat protein; Provisional Pssm-ID: 165206 [Multi-domain] Cd Length: 413 Bit Score: 43.44 E-value: 1.16e-03
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PLN03192 | PLN03192 | Voltage-dependent potassium channel; Provisional |
1495-1567 | 2.18e-03 | ||||||||
Voltage-dependent potassium channel; Provisional Pssm-ID: 215625 [Multi-domain] Cd Length: 823 Bit Score: 42.93 E-value: 2.18e-03
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Ank_5 | pfam13857 | Ankyrin repeats (many copies); |
1554-1608 | 2.92e-03 | ||||||||
Ankyrin repeats (many copies); Pssm-ID: 433530 [Multi-domain] Cd Length: 56 Bit Score: 37.71 E-value: 2.92e-03
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PHA03269 | PHA03269 | envelope glycoprotein C; Provisional |
175-336 | 3.77e-03 | ||||||||
envelope glycoprotein C; Provisional Pssm-ID: 165527 [Multi-domain] Cd Length: 566 Bit Score: 42.02 E-value: 3.77e-03
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PRK12323 | PRK12323 | DNA polymerase III subunit gamma/tau; |
311-569 | 7.75e-03 | ||||||||
DNA polymerase III subunit gamma/tau; Pssm-ID: 237057 [Multi-domain] Cd Length: 700 Bit Score: 41.01 E-value: 7.75e-03
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PHA02876 | PHA02876 | ankyrin repeat protein; Provisional |
1550-1612 | 8.94e-03 | ||||||||
ankyrin repeat protein; Provisional Pssm-ID: 165207 [Multi-domain] Cd Length: 682 Bit Score: 40.82 E-value: 8.94e-03
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PHA02795 | PHA02795 | ankyrin-like protein; Provisional |
1526-1568 | 9.42e-03 | ||||||||
ankyrin-like protein; Provisional Pssm-ID: 165157 [Multi-domain] Cd Length: 437 Bit Score: 40.36 E-value: 9.42e-03
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Blast search parameters | ||||
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