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Conserved domains on  [gi|2020851986|ref|XP_040321049|]
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clathrin heavy chain 2 isoform X1 [Puma yagouaroundi]

Protein Classification

clathrin heavy chain( domain architecture ID 12019196)

clathrin heavy chain is a component of clathrin, the major protein of the polyhedral coat of coated pits and vesicles

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CLH smart00299
Clathrin heavy chain repeat homology;
1274-1416 4.69e-41

Clathrin heavy chain repeat homology;


:

Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 148.19  E-value: 4.69e-41
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2020851986  1274 LHIVIHADELEELIRYYQDRGYFEELISLLEAALGLERAHMGMFTELAILYSKFKPQKMPEHLELFWSRVNIPKVLRAAE 1353
Cdd:smart00299    1 LLEVSDPIDVSEVVELFEKRNLLEELIPYLESALKLNSENPALQTKLIELYAKYDPQKEIERLDNKSNHYDIEKVGKLCE 80

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2020851986  1354 QAHLWAELVFLYDKYEEYDNAVLTMINHPTDAwreGQFKDVIAKVANVELYYKALQFCLDYKP 1416
Cdd:smart00299   81 KAKLYEEAVELYKKDGNFKDAIVTLIEHLGNY---EKAIEYFVKQNNPELWAEVLKALLDKPR 140
CLH smart00299
Clathrin heavy chain repeat homology;
979-1119 7.23e-34

Clathrin heavy chain repeat homology;


:

Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 127.78  E-value: 7.23e-34
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2020851986   979 LSETQDPEEVSVTVKAFMTADLPNELIELLEKIVLDNSvfsEHRNLQNLLILTAIKADRTRVMEYISR-LDNYDAPDIAN 1057
Cdd:smart00299    1 LLEVSDPIDVSEVVELFEKRNLLEELIPYLESALKLNS---ENPALQTKLIELYAKYDPQKEIERLDNkSNHYDIEKVGK 77

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2020851986  1058 IAVSSALYEEAFTIFRKFDVNASAIQVLIEHIGNLDRAYEFAERCNEPAVWSQLACAQLQKD 1119
Cdd:smart00299   78 LCEKAKLYEEAVELYKKDGNFKDAIVTLIEHLGNYEKAIEYFVKQNNPELWAEVLKALLDKP 139
Clathrin pfam00637
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are ...
 1428-1564 1.14e-32

Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are composed of multiple alpha helical repeats. They occur in the arm region of the Clathrin heavy chain.


:

Pssm-ID: 459884 [Multi-domain]  Cd Length: 142  Bit Score: 124.29  E-value: 1.14e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2020851986 1428 PRLDHTRTVGFFSKAGQLPLVKPYLRSVQ---SHNNKSVNEALNHLLTEEEDYQGLRASIDAYDNFDNIALAQRLEKHQL 1504
Cdd:pfam00637    6 DPIDVSRVVKLFEKAGLLEELISYLESALkedSRENPALQTALIELYAKYDDPEELEEFLKKNNNYDLEKVAKLCEKADL 85

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2020851986 1505 IEFRRiaaYLYKGNNRWAQSVELCKKDHLYKDAMQHAAESRDAELAEKLLQWFLEEGKRE 1564
Cdd:pfam00637   86 YEEAV---ILYKKIGNWKEAISLLKKLGDYKDAIEYAVKSSNPELWEELLEALLDNGRFE 142
CLH smart00299
Clathrin heavy chain repeat homology;
686-824 1.13e-31

Clathrin heavy chain repeat homology;


:

Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 121.23  E-value: 1.13e-31
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2020851986   686 ASKYHEQLGTQSLVELFESFKSYEGLFYFLGSIVNF-SQDPDVHLKYIQAACKTGQIKEVERICRESNCYNAERVKNFLK 764
Cdd:smart00299    1 LLEVSDPIDVSEVVELFEKRNLLEELIPYLESALKLnSENPALQTKLIELYAKYDPQKEIERLDNKSNHYDIEKVGKLCE 80

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2020851986   765 EAKLTDQLPLIIVCDrFDFVHDLVLYLYR-NNLQKYIEIYIQKVNPSRIPAVVGGLLDVDC 824
Cdd:smart00299   81 KAKLYEEAVELYKKD-GNFKDAIVTLIEHlGNYEKAIEYFVKQNNPELWAEVLKALLDKPR 140
CLH smart00299
Clathrin heavy chain repeat homology;
833-960 1.37e-31

Clathrin heavy chain repeat homology;


:

Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 121.23  E-value: 1.37e-31
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2020851986   833 IMVVRGQFSTDELVAEVEKRNRLKLLLPWLESRSHEGCEEPATHNALAKIYIDSNNSP--ERFLRENAYYDSRVVGRYCE 910
Cdd:smart00299    1 LLEVSDPIDVSEVVELFEKRNLLEELIPYLESALKLNSENPALQTKLIELYAKYDPQKeiERLDNKSNHYDIEKVGKLCE 80

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|..
gi 2020851986   911 KRDPH-LACVAYERGQCDLELIKVCNENS-LFKSEARYLVRRKDPELWAHVL 960
Cdd:smart00299   81 KAKLYeEAVELYKKDGNFKDAIVTLIEHLgNYEKAIEYFVKQNNPELWAEVL 132
CLH smart00299
Clathrin heavy chain repeat homology;
541-671 1.27e-30

Clathrin heavy chain repeat homology;


:

Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 118.53  E-value: 1.27e-30
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2020851986   541 EPLANIDQIVDVFMENSLIQQCTSFLLDALKNNrPAEGHLQTRLLEMNLIHAPQVADAILGNqMFTHYDRAHIAQLCEKA 620
Cdd:smart00299    5 SDPIDVSEVVELFEKRNLLEELIPYLESALKLN-SENPALQTKLIELYAKYDPQKEIERLDN-KSNHYDIEKVGKLCEKA 82

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....
gi 2020851986   621 GLLQRALEHYTDLYDIKRAVVHT--HLLNPEWLVSFFGS-LSVEDSLACLHALL 671
Cdd:smart00299   83 KLYEEAVELYKKDGNFKDAIVTLieHLGNYEKAIEYFVKqNNPELWAEVLKALL 136
Clathrin pfam00637
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are ...
 1128-1267 1.61e-30

Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are composed of multiple alpha helical repeats. They occur in the arm region of the Clathrin heavy chain.


:

Pssm-ID: 459884 [Multi-domain]  Cd Length: 142  Bit Score: 118.13  E-value: 1.61e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2020851986 1128 YIRADDPSSYLEVVQAASRSNNWEDLVKFLQMARKKGRE--SYIETELIFALAKTGRLSELEDCINGPNNAHIQQVGDRC 1205
Cdd:pfam00637    1 LIESTDPIDVSRVVKLFEKAGLLEELISYLESALKEDSRenPALQTALIELYAKYDDPEELEEFLKKNNNYDLEKVAKLC 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2020851986 1206 YEEGMYEAAKLLYSSVSNFARLASTLVHLGEYQAAVDSSRKANSTRTWKEVCFACVDGQEFR 1267
Cdd:pfam00637   81 EKADLYEEAVILYKKIGNWKEAISLLKKLGDYKDAIEYAVKSSNPELWEELLEALLDNGRFE 142
Clathrin_H_link pfam13838
Clathrin-H-link; This short domain is found on clathrins, and often appears on proteins ...
 356-421 2.87e-19

Clathrin-H-link; This short domain is found on clathrins, and often appears on proteins directly downstream from the Clathrin-link domain pfam09268.


:

Pssm-ID: 463995  Cd Length: 66  Bit Score: 83.41  E-value: 2.87e-19
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2020851986  356 NLAGAEELFVRKFTTLFAQGSYAEAAKVAASAPKGVLRTSDTVRKFQSIPAQPGQASPLLQYFGIL 421
Cdd:pfam13838    1 GLPGADDLYFQQFNQLLNQGDYAEAAKVAANSPRGALRTPETIQRFKQLPAQPGQLSPILQYFGTL 66
Clathrin-link pfam09268
Clathrin, heavy-chain linker; Members of this family adopt a structure consisting of ...
 331-354 8.66e-07

Clathrin, heavy-chain linker; Members of this family adopt a structure consisting of alpha-alpha superhelix. They are predominantly found in clathrin, where they act as a heavy-chain linker domain.


:

Pssm-ID: 462732  Cd Length: 24  Bit Score: 46.67  E-value: 8.66e-07
                           10        20
                   ....*....|....*....|....
gi 2020851986  331 EDNIVNYATSVLQNPDLGLRLAIR 354
Cdd:pfam09268    1 EDNIIPYILNTLQNPDLALRLASR 24
Clathrin_propel pfam01394
Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that ...
 296-330 1.57e-06

Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that surrounds coated vesicles. The soluble assembly unit, a triskelion, contains three heavy chains and three light chains in an extended three-legged structure. Each leg contains one heavy and one light chain. The N-terminus of the heavy chain is known as the globular domain, and is composed of seven repeats which form a beta propeller.


:

Pssm-ID: 460192  Cd Length: 37  Bit Score: 46.25  E-value: 1.57e-06
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 2020851986  296 NRISADTIFVTAPHESTSGIIGVN--KKGQVLSVCVE 330
Cdd:pfam01394    1 NAISAIIIFPTATMESWLFIIAINgtKKGQVQIVDVE 37
Clathrin_propel pfam01394
Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that ...
 19-55 8.92e-05

Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that surrounds coated vesicles. The soluble assembly unit, a triskelion, contains three heavy chains and three light chains in an extended three-legged structure. Each leg contains one heavy and one light chain. The N-terminus of the heavy chain is known as the globular domain, and is composed of seven repeats which form a beta propeller.


:

Pssm-ID: 460192  Cd Length: 37  Bit Score: 41.25  E-value: 8.92e-05
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 2020851986   19 GINPANIGFSTLTMESDKFICVREKVGeQAQVVIVDM 55
Cdd:pfam01394    1 NAISAIIIFPTATMESWLFIIAINGTK-KGQVQIVDV 36
Clathrin_propel pfam01394
Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that ...
 198-234 1.83e-04

Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that surrounds coated vesicles. The soluble assembly unit, a triskelion, contains three heavy chains and three light chains in an extended three-legged structure. Each leg contains one heavy and one light chain. The N-terminus of the heavy chain is known as the globular domain, and is composed of seven repeats which form a beta propeller.


:

Pssm-ID: 460192  Cd Length: 37  Bit Score: 40.48  E-value: 1.83e-04
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 2020851986  198 AAAFAEFKSEGNAKPATLFCFAVRSPTGGKLHIIEVG 234
Cdd:pfam01394    1 NAISAIIIFPTATMESWLFIIAINGTKKGQVQIVDVE 37
Clathrin_propel pfam01394
Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that ...
 256-288 5.66e-04

Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that surrounds coated vesicles. The soluble assembly unit, a triskelion, contains three heavy chains and three light chains in an extended three-legged structure. Each leg contains one heavy and one light chain. The N-terminus of the heavy chain is known as the globular domain, and is composed of seven repeats which form a beta propeller.


:

Pssm-ID: 460192  Cd Length: 37  Bit Score: 38.94  E-value: 5.66e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 2020851986  256 AQTDFPVAMQIGAKHGVIYLITKYGYLHMYDLE 288
Cdd:pfam01394    5 AIIIFPTATMESWLFIIAINGTKKGQVQIVDVE 37
 
Name Accession Description Interval E-value
CLH smart00299
Clathrin heavy chain repeat homology;
1274-1416 4.69e-41

Clathrin heavy chain repeat homology;


Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 148.19  E-value: 4.69e-41
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2020851986  1274 LHIVIHADELEELIRYYQDRGYFEELISLLEAALGLERAHMGMFTELAILYSKFKPQKMPEHLELFWSRVNIPKVLRAAE 1353
Cdd:smart00299    1 LLEVSDPIDVSEVVELFEKRNLLEELIPYLESALKLNSENPALQTKLIELYAKYDPQKEIERLDNKSNHYDIEKVGKLCE 80

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2020851986  1354 QAHLWAELVFLYDKYEEYDNAVLTMINHPTDAwreGQFKDVIAKVANVELYYKALQFCLDYKP 1416
Cdd:smart00299   81 KAKLYEEAVELYKKDGNFKDAIVTLIEHLGNY---EKAIEYFVKQNNPELWAEVLKALLDKPR 140
CLH smart00299
Clathrin heavy chain repeat homology;
979-1119 7.23e-34

Clathrin heavy chain repeat homology;


Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 127.78  E-value: 7.23e-34
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2020851986   979 LSETQDPEEVSVTVKAFMTADLPNELIELLEKIVLDNSvfsEHRNLQNLLILTAIKADRTRVMEYISR-LDNYDAPDIAN 1057
Cdd:smart00299    1 LLEVSDPIDVSEVVELFEKRNLLEELIPYLESALKLNS---ENPALQTKLIELYAKYDPQKEIERLDNkSNHYDIEKVGK 77

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2020851986  1058 IAVSSALYEEAFTIFRKFDVNASAIQVLIEHIGNLDRAYEFAERCNEPAVWSQLACAQLQKD 1119
Cdd:smart00299   78 LCEKAKLYEEAVELYKKDGNFKDAIVTLIEHLGNYEKAIEYFVKQNNPELWAEVLKALLDKP 139
Clathrin pfam00637
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are ...
 1428-1564 1.14e-32

Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are composed of multiple alpha helical repeats. They occur in the arm region of the Clathrin heavy chain.


Pssm-ID: 459884 [Multi-domain]  Cd Length: 142  Bit Score: 124.29  E-value: 1.14e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2020851986 1428 PRLDHTRTVGFFSKAGQLPLVKPYLRSVQ---SHNNKSVNEALNHLLTEEEDYQGLRASIDAYDNFDNIALAQRLEKHQL 1504
Cdd:pfam00637    6 DPIDVSRVVKLFEKAGLLEELISYLESALkedSRENPALQTALIELYAKYDDPEELEEFLKKNNNYDLEKVAKLCEKADL 85

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2020851986 1505 IEFRRiaaYLYKGNNRWAQSVELCKKDHLYKDAMQHAAESRDAELAEKLLQWFLEEGKRE 1564
Cdd:pfam00637   86 YEEAV---ILYKKIGNWKEAISLLKKLGDYKDAIEYAVKSSNPELWEELLEALLDNGRFE 142
CLH smart00299
Clathrin heavy chain repeat homology;
686-824 1.13e-31

Clathrin heavy chain repeat homology;


Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 121.23  E-value: 1.13e-31
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2020851986   686 ASKYHEQLGTQSLVELFESFKSYEGLFYFLGSIVNF-SQDPDVHLKYIQAACKTGQIKEVERICRESNCYNAERVKNFLK 764
Cdd:smart00299    1 LLEVSDPIDVSEVVELFEKRNLLEELIPYLESALKLnSENPALQTKLIELYAKYDPQKEIERLDNKSNHYDIEKVGKLCE 80

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2020851986   765 EAKLTDQLPLIIVCDrFDFVHDLVLYLYR-NNLQKYIEIYIQKVNPSRIPAVVGGLLDVDC 824
Cdd:smart00299   81 KAKLYEEAVELYKKD-GNFKDAIVTLIEHlGNYEKAIEYFVKQNNPELWAEVLKALLDKPR 140
CLH smart00299
Clathrin heavy chain repeat homology;
833-960 1.37e-31

Clathrin heavy chain repeat homology;


Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 121.23  E-value: 1.37e-31
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2020851986   833 IMVVRGQFSTDELVAEVEKRNRLKLLLPWLESRSHEGCEEPATHNALAKIYIDSNNSP--ERFLRENAYYDSRVVGRYCE 910
Cdd:smart00299    1 LLEVSDPIDVSEVVELFEKRNLLEELIPYLESALKLNSENPALQTKLIELYAKYDPQKeiERLDNKSNHYDIEKVGKLCE 80

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|..
gi 2020851986   911 KRDPH-LACVAYERGQCDLELIKVCNENS-LFKSEARYLVRRKDPELWAHVL 960
Cdd:smart00299   81 KAKLYeEAVELYKKDGNFKDAIVTLIEHLgNYEKAIEYFVKQNNPELWAEVL 132
Clathrin pfam00637
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are ...
 979-1119 1.12e-30

Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are composed of multiple alpha helical repeats. They occur in the arm region of the Clathrin heavy chain.


Pssm-ID: 459884 [Multi-domain]  Cd Length: 142  Bit Score: 118.51  E-value: 1.12e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2020851986  979 LSETQDPEEVSVTVKAFMTADLPNELIELLEKIVLDNSvfSEHRNLQNLLILTAIKADR-TRVMEYISRLDNYDAPDIAN 1057
Cdd:pfam00637    1 LIESTDPIDVSRVVKLFEKAGLLEELISYLESALKEDS--RENPALQTALIELYAKYDDpEELEEFLKKNNNYDLEKVAK 78

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2020851986 1058 IAVSSALYEEAFTIFRKFDVNASAIqVLIEHIGNLDRAYEFAERCNEPAVWSQLACAQLQKD 1119
Cdd:pfam00637   79 LCEKADLYEEAVILYKKIGNWKEAI-SLLKKLGDYKDAIEYAVKSSNPELWEELLEALLDNG 139
CLH smart00299
Clathrin heavy chain repeat homology;
541-671 1.27e-30

Clathrin heavy chain repeat homology;


Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 118.53  E-value: 1.27e-30
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2020851986   541 EPLANIDQIVDVFMENSLIQQCTSFLLDALKNNrPAEGHLQTRLLEMNLIHAPQVADAILGNqMFTHYDRAHIAQLCEKA 620
Cdd:smart00299    5 SDPIDVSEVVELFEKRNLLEELIPYLESALKLN-SENPALQTKLIELYAKYDPQKEIERLDN-KSNHYDIEKVGKLCEKA 82

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....
gi 2020851986   621 GLLQRALEHYTDLYDIKRAVVHT--HLLNPEWLVSFFGS-LSVEDSLACLHALL 671
Cdd:smart00299   83 KLYEEAVELYKKDGNFKDAIVTLieHLGNYEKAIEYFVKqNNPELWAEVLKALL 136
Clathrin pfam00637
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are ...
 1128-1267 1.61e-30

Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are composed of multiple alpha helical repeats. They occur in the arm region of the Clathrin heavy chain.


Pssm-ID: 459884 [Multi-domain]  Cd Length: 142  Bit Score: 118.13  E-value: 1.61e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2020851986 1128 YIRADDPSSYLEVVQAASRSNNWEDLVKFLQMARKKGRE--SYIETELIFALAKTGRLSELEDCINGPNNAHIQQVGDRC 1205
Cdd:pfam00637    1 LIESTDPIDVSRVVKLFEKAGLLEELISYLESALKEDSRenPALQTALIELYAKYDDPEELEEFLKKNNNYDLEKVAKLC 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2020851986 1206 YEEGMYEAAKLLYSSVSNFARLASTLVHLGEYQAAVDSSRKANSTRTWKEVCFACVDGQEFR 1267
Cdd:pfam00637   81 EKADLYEEAVILYKKIGNWKEAISLLKKLGDYKDAIEYAVKSSNPELWEELLEALLDNGRFE 142
CLH smart00299
Clathrin heavy chain repeat homology;
1128-1265 2.04e-30

Clathrin heavy chain repeat homology;


Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 117.76  E-value: 2.04e-30
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2020851986  1128 YIRADDPSSYLEVVQAASRSNNWEDLVKFLQMARKKGRE-SYIETELIFALAKTGRLSELEDCINGPNNAHIQQVGDRCY 1206
Cdd:smart00299    1 LLEVSDPIDVSEVVELFEKRNLLEELIPYLESALKLNSEnPALQTKLIELYAKYDPQKEIERLDNKSNHYDIEKVGKLCE 80

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2020851986  1207 EEGMYEAAKLLYSSVSNFARLASTLV-HLGEYQAAVDSSRKANSTRTWKEVCFACVDGQE 1265
Cdd:smart00299   81 KAKLYEEAVELYKKDGNFKDAIVTLIeHLGNYEKAIEYFVKQNNPELWAEVLKALLDKPR 140
Clathrin pfam00637
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are ...
 1274-1416 5.33e-29

Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are composed of multiple alpha helical repeats. They occur in the arm region of the Clathrin heavy chain.


Pssm-ID: 459884 [Multi-domain]  Cd Length: 142  Bit Score: 113.89  E-value: 5.33e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2020851986 1274 LHIVIHADELEELIRYYQDRGYFEELISLLEAALGL-ERAHMGMFTELAILYSKF-KPQKMPEHLELFWSrVNIPKVLRA 1351
Cdd:pfam00637    1 LIESTDPIDVSRVVKLFEKAGLLEELISYLESALKEdSRENPALQTALIELYAKYdDPEELEEFLKKNNN-YDLEKVAKL 79

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2020851986 1352 AEQAHLWAELVFLYDKYEEYDNAVLTMinHPTDAWREGQfkDVIAKVANVELYYKALQFCLDYKP 1416
Cdd:pfam00637   80 CEKADLYEEAVILYKKIGNWKEAISLL--KKLGDYKDAI--EYAVKSSNPELWEELLEALLDNGR 140
Clathrin pfam00637
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are ...
 843-970 1.30e-27

Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are composed of multiple alpha helical repeats. They occur in the arm region of the Clathrin heavy chain.


Pssm-ID: 459884 [Multi-domain]  Cd Length: 142  Bit Score: 110.04  E-value: 1.30e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2020851986  843 DELVAEVEKRNRLKLLLPWLES-RSHEGCEEPATHNALAKIYIDSN--NSPERFLRENAYYDSRVVGRYCEKRDPH-LAC 918
Cdd:pfam00637   11 SRVVKLFEKAGLLEELISYLESaLKEDSRENPALQTALIELYAKYDdpEELEEFLKKNNNYDLEKVAKLCEKADLYeEAV 90

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 2020851986  919 VAYERGQCDLELIKVCNENSLFKSEARYLVRRKDPELWAHVLEETNPSRRQL 970
Cdd:pfam00637   91 ILYKKIGNWKEAISLLKKLGDYKDAIEYAVKSSNPELWEELLEALLDNGRFE 142
CLH smart00299
Clathrin heavy chain repeat homology;
1427-1578 1.57e-26

Clathrin heavy chain repeat homology;


Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 106.59  E-value: 1.57e-26
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2020851986  1427 APRLDHTRTVGFFSKAGQLPLVKPYLRSVQSHNnkSVNEALNHLLTEEEDYQGLRASIDAYDNFdnialaqrlekHQLIE 1506
Cdd:smart00299    5 SDPIDVSEVVELFEKRNLLEELIPYLESALKLN--SENPALQTKLIELYAKYDPQKEIERLDNK-----------SNHYD 71

                            90       100       110       120       130       140       150
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2020851986  1507 FRRIAAYLYKGNNrWAQSVELCKKDHLYKDAMQHAAEsrDAELAEKLLQWFLEEGKRECFAASLFTCYDLLP 1578
Cdd:smart00299   72 IEKVGKLCEKAKL-YEEAVELYKKDGNFKDAIVTLIE--HLGNYEKAIEYFVKQNNPELWAEVLKALLDKPR 140
Clathrin pfam00637
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are ...
 688-826 2.93e-25

Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are composed of multiple alpha helical repeats. They occur in the arm region of the Clathrin heavy chain.


Pssm-ID: 459884 [Multi-domain]  Cd Length: 142  Bit Score: 103.10  E-value: 2.93e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2020851986  688 KYHEQLGTQSLVELFESFKSYEGLFYFLGSIVNFS--QDPDVHLKYIQAACKTGQIKEVERICRESNCYNAERVKNFLKE 765
Cdd:pfam00637    3 ESTDPIDVSRVVKLFEKAGLLEELISYLESALKEDsrENPALQTALIELYAKYDDPEELEEFLKKNNNYDLEKVAKLCEK 82

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2020851986  766 AKLTDQLPLIIVCdrFDFVHDLV-LYLYRNNLQKYIEIYIQKVNPSRIPAVVGGLLDVDCSE 826
Cdd:pfam00637   83 ADLYEEAVILYKK--IGNWKEAIsLLKKLGDYKDAIEYAVKSSNPELWEELLEALLDNGRFE 142
Clathrin pfam00637
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are ...
 541-667 7.76e-23

Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are composed of multiple alpha helical repeats. They occur in the arm region of the Clathrin heavy chain.


Pssm-ID: 459884 [Multi-domain]  Cd Length: 142  Bit Score: 96.17  E-value: 7.76e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2020851986  541 EPLANIDQIVDVFMENSLIQQCTSFLLDALKNNRPAEGHLQTRLLEMNLIHAP-QVADAILgnQMFTHYDRAHIAQLCEK 619
Cdd:pfam00637    5 TDPIDVSRVVKLFEKAGLLEELISYLESALKEDSRENPALQTALIELYAKYDDpEELEEFL--KKNNNYDLEKVAKLCEK 82

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 2020851986  620 AGLLQRALEHYTDLYDIKRAV-VHTHLLNPEWLVSFFGSLSVEDSLACL 667
Cdd:pfam00637   83 ADLYEEAVILYKKIGNWKEAIsLLKKLGDYKDAIEYAVKSSNPELWEEL 131
Clathrin_H_link pfam13838
Clathrin-H-link; This short domain is found on clathrins, and often appears on proteins ...
 356-421 2.87e-19

Clathrin-H-link; This short domain is found on clathrins, and often appears on proteins directly downstream from the Clathrin-link domain pfam09268.


Pssm-ID: 463995  Cd Length: 66  Bit Score: 83.41  E-value: 2.87e-19
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2020851986  356 NLAGAEELFVRKFTTLFAQGSYAEAAKVAASAPKGVLRTSDTVRKFQSIPAQPGQASPLLQYFGIL 421
Cdd:pfam13838    1 GLPGADDLYFQQFNQLLNQGDYAEAAKVAANSPRGALRTPETIQRFKQLPAQPGQLSPILQYFGTL 66
Clathrin-link pfam09268
Clathrin, heavy-chain linker; Members of this family adopt a structure consisting of ...
 331-354 8.66e-07

Clathrin, heavy-chain linker; Members of this family adopt a structure consisting of alpha-alpha superhelix. They are predominantly found in clathrin, where they act as a heavy-chain linker domain.


Pssm-ID: 462732  Cd Length: 24  Bit Score: 46.67  E-value: 8.66e-07
                           10        20
                   ....*....|....*....|....
gi 2020851986  331 EDNIVNYATSVLQNPDLGLRLAIR 354
Cdd:pfam09268    1 EDNIIPYILNTLQNPDLALRLASR 24
Clathrin_propel pfam01394
Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that ...
 296-330 1.57e-06

Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that surrounds coated vesicles. The soluble assembly unit, a triskelion, contains three heavy chains and three light chains in an extended three-legged structure. Each leg contains one heavy and one light chain. The N-terminus of the heavy chain is known as the globular domain, and is composed of seven repeats which form a beta propeller.


Pssm-ID: 460192  Cd Length: 37  Bit Score: 46.25  E-value: 1.57e-06
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 2020851986  296 NRISADTIFVTAPHESTSGIIGVN--KKGQVLSVCVE 330
Cdd:pfam01394    1 NAISAIIIFPTATMESWLFIIAINgtKKGQVQIVDVE 37
Clathrin_propel pfam01394
Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that ...
 19-55 8.92e-05

Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that surrounds coated vesicles. The soluble assembly unit, a triskelion, contains three heavy chains and three light chains in an extended three-legged structure. Each leg contains one heavy and one light chain. The N-terminus of the heavy chain is known as the globular domain, and is composed of seven repeats which form a beta propeller.


Pssm-ID: 460192  Cd Length: 37  Bit Score: 41.25  E-value: 8.92e-05
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 2020851986   19 GINPANIGFSTLTMESDKFICVREKVGeQAQVVIVDM 55
Cdd:pfam01394    1 NAISAIIIFPTATMESWLFIIAINGTK-KGQVQIVDV 36
Coatomer_WDAD_beta-like cd22947
Coatomer WD Associated Region from Coatomer Subunit Beta and Beta'; Coatomer subunit beta', ...
 1064-1185 1.02e-04

Coatomer WD Associated Region from Coatomer Subunit Beta and Beta'; Coatomer subunit beta', also called beta'-coat protein; beta'-COP; p102, is a component of the coatomer, which is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complexes are hetero-oligomers composed of at least an alpha, beta, beta', gamma, delta, epsilon and zeta subunit. It is a heptameric complex that can polymerize into a cage to deform the membrane into a bud. This model corresponds to the WD-associated (WDAD) region found in coatomer subunits beta and beta' and is composed of a beta-propeller and an alpha-solenoid. The WD40 domain is found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly. It typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40. Between the GH and WD lies a conserved core. It forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet. Each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade. The last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure. The residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands allowing them to bind either stably or reversibly.


Pssm-ID: 438572  Cd Length: 475  Bit Score: 47.08  E-value: 1.02e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2020851986 1064 LYEEAFTIFR----KFDVnasAIQvliehIGNLDRAYEFAERCNEPAVWSQLACAQLQKDLVKEAIDSYIRADDPSSYLE 1139
Cdd:cd22947    327 LKELALEVSTdpdhKFEL---ALQ-----LGDLDLALEIARESESESKWKQLGDLALSKGDFDLAEECLKKAGDLSGLLL 398

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2020851986 1140 VvqaASRSNNWEDLVKFLQMARKKGR--------------ESYIETelifaLAKTGRLSE 1185
Cdd:cd22947    399 L---YSSTGDKEGLEELAELAEAAGKnniaflayfllgdlDKCVDL-----LIKTGRLPE 450
Clathrin_propel pfam01394
Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that ...
 198-234 1.83e-04

Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that surrounds coated vesicles. The soluble assembly unit, a triskelion, contains three heavy chains and three light chains in an extended three-legged structure. Each leg contains one heavy and one light chain. The N-terminus of the heavy chain is known as the globular domain, and is composed of seven repeats which form a beta propeller.


Pssm-ID: 460192  Cd Length: 37  Bit Score: 40.48  E-value: 1.83e-04
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 2020851986  198 AAAFAEFKSEGNAKPATLFCFAVRSPTGGKLHIIEVG 234
Cdd:pfam01394    1 NAISAIIIFPTATMESWLFIIAINGTKKGQVQIVDVE 37
Clathrin_propel pfam01394
Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that ...
 256-288 5.66e-04

Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that surrounds coated vesicles. The soluble assembly unit, a triskelion, contains three heavy chains and three light chains in an extended three-legged structure. Each leg contains one heavy and one light chain. The N-terminus of the heavy chain is known as the globular domain, and is composed of seven repeats which form a beta propeller.


Pssm-ID: 460192  Cd Length: 37  Bit Score: 38.94  E-value: 5.66e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 2020851986  256 AQTDFPVAMQIGAKHGVIYLITKYGYLHMYDLE 288
Cdd:pfam01394    5 AIIIFPTATMESWLFIIAINGTKKGQVQIVDVE 37
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 1055-1219 1.01e-03

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 43.18  E-value: 1.01e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2020851986 1055 IANIAVSSALYEEAFTIFRKF----DVNASAIQVLI---EHIGNLDRAYEFAERC-----NEPAVWSQLACAQLQKDLVK 1122
Cdd:COG2956     82 LAQDYLKAGLLDRAEELLEKLleldPDDAEALRLLAeiyEQEGDWEKAIEVLERLlklgpENAHAYCELAELYLEQGDYD 161

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2020851986 1123 EAIDSYIRA-----DDPSSYLEVVQAASRSNNWEDLVKFLQMARKKGRESY-IETELIFALAKTGRLSE----LEDCI-N 1191
Cdd:COG2956    162 EAIEALEKAlkldpDCARALLLLAELYLEQGDYEEAIAALERALEQDPDYLpALPRLAELYEKLGDPEEalelLRKALeL 241

                          170       180
                   ....*....|....*....|....*...
gi 2020851986 1192 GPNNAHIQQVGDRCYEEGMYEAAKLLYS 1219
Cdd:COG2956    242 DPSDDLLLALADLLERKEGLEAALALLE 269
 
Name Accession Description Interval E-value
CLH smart00299
Clathrin heavy chain repeat homology;
1274-1416 4.69e-41

Clathrin heavy chain repeat homology;


Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 148.19  E-value: 4.69e-41
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2020851986  1274 LHIVIHADELEELIRYYQDRGYFEELISLLEAALGLERAHMGMFTELAILYSKFKPQKMPEHLELFWSRVNIPKVLRAAE 1353
Cdd:smart00299    1 LLEVSDPIDVSEVVELFEKRNLLEELIPYLESALKLNSENPALQTKLIELYAKYDPQKEIERLDNKSNHYDIEKVGKLCE 80

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2020851986  1354 QAHLWAELVFLYDKYEEYDNAVLTMINHPTDAwreGQFKDVIAKVANVELYYKALQFCLDYKP 1416
Cdd:smart00299   81 KAKLYEEAVELYKKDGNFKDAIVTLIEHLGNY---EKAIEYFVKQNNPELWAEVLKALLDKPR 140
CLH smart00299
Clathrin heavy chain repeat homology;
979-1119 7.23e-34

Clathrin heavy chain repeat homology;


Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 127.78  E-value: 7.23e-34
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2020851986   979 LSETQDPEEVSVTVKAFMTADLPNELIELLEKIVLDNSvfsEHRNLQNLLILTAIKADRTRVMEYISR-LDNYDAPDIAN 1057
Cdd:smart00299    1 LLEVSDPIDVSEVVELFEKRNLLEELIPYLESALKLNS---ENPALQTKLIELYAKYDPQKEIERLDNkSNHYDIEKVGK 77

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2020851986  1058 IAVSSALYEEAFTIFRKFDVNASAIQVLIEHIGNLDRAYEFAERCNEPAVWSQLACAQLQKD 1119
Cdd:smart00299   78 LCEKAKLYEEAVELYKKDGNFKDAIVTLIEHLGNYEKAIEYFVKQNNPELWAEVLKALLDKP 139
Clathrin pfam00637
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are ...
 1428-1564 1.14e-32

Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are composed of multiple alpha helical repeats. They occur in the arm region of the Clathrin heavy chain.


Pssm-ID: 459884 [Multi-domain]  Cd Length: 142  Bit Score: 124.29  E-value: 1.14e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2020851986 1428 PRLDHTRTVGFFSKAGQLPLVKPYLRSVQ---SHNNKSVNEALNHLLTEEEDYQGLRASIDAYDNFDNIALAQRLEKHQL 1504
Cdd:pfam00637    6 DPIDVSRVVKLFEKAGLLEELISYLESALkedSRENPALQTALIELYAKYDDPEELEEFLKKNNNYDLEKVAKLCEKADL 85

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2020851986 1505 IEFRRiaaYLYKGNNRWAQSVELCKKDHLYKDAMQHAAESRDAELAEKLLQWFLEEGKRE 1564
Cdd:pfam00637   86 YEEAV---ILYKKIGNWKEAISLLKKLGDYKDAIEYAVKSSNPELWEELLEALLDNGRFE 142
CLH smart00299
Clathrin heavy chain repeat homology;
686-824 1.13e-31

Clathrin heavy chain repeat homology;


Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 121.23  E-value: 1.13e-31
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2020851986   686 ASKYHEQLGTQSLVELFESFKSYEGLFYFLGSIVNF-SQDPDVHLKYIQAACKTGQIKEVERICRESNCYNAERVKNFLK 764
Cdd:smart00299    1 LLEVSDPIDVSEVVELFEKRNLLEELIPYLESALKLnSENPALQTKLIELYAKYDPQKEIERLDNKSNHYDIEKVGKLCE 80

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2020851986   765 EAKLTDQLPLIIVCDrFDFVHDLVLYLYR-NNLQKYIEIYIQKVNPSRIPAVVGGLLDVDC 824
Cdd:smart00299   81 KAKLYEEAVELYKKD-GNFKDAIVTLIEHlGNYEKAIEYFVKQNNPELWAEVLKALLDKPR 140
CLH smart00299
Clathrin heavy chain repeat homology;
833-960 1.37e-31

Clathrin heavy chain repeat homology;


Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 121.23  E-value: 1.37e-31
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2020851986   833 IMVVRGQFSTDELVAEVEKRNRLKLLLPWLESRSHEGCEEPATHNALAKIYIDSNNSP--ERFLRENAYYDSRVVGRYCE 910
Cdd:smart00299    1 LLEVSDPIDVSEVVELFEKRNLLEELIPYLESALKLNSENPALQTKLIELYAKYDPQKeiERLDNKSNHYDIEKVGKLCE 80

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|..
gi 2020851986   911 KRDPH-LACVAYERGQCDLELIKVCNENS-LFKSEARYLVRRKDPELWAHVL 960
Cdd:smart00299   81 KAKLYeEAVELYKKDGNFKDAIVTLIEHLgNYEKAIEYFVKQNNPELWAEVL 132
Clathrin pfam00637
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are ...
 979-1119 1.12e-30

Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are composed of multiple alpha helical repeats. They occur in the arm region of the Clathrin heavy chain.


Pssm-ID: 459884 [Multi-domain]  Cd Length: 142  Bit Score: 118.51  E-value: 1.12e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2020851986  979 LSETQDPEEVSVTVKAFMTADLPNELIELLEKIVLDNSvfSEHRNLQNLLILTAIKADR-TRVMEYISRLDNYDAPDIAN 1057
Cdd:pfam00637    1 LIESTDPIDVSRVVKLFEKAGLLEELISYLESALKEDS--RENPALQTALIELYAKYDDpEELEEFLKKNNNYDLEKVAK 78

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2020851986 1058 IAVSSALYEEAFTIFRKFDVNASAIqVLIEHIGNLDRAYEFAERCNEPAVWSQLACAQLQKD 1119
Cdd:pfam00637   79 LCEKADLYEEAVILYKKIGNWKEAI-SLLKKLGDYKDAIEYAVKSSNPELWEELLEALLDNG 139
CLH smart00299
Clathrin heavy chain repeat homology;
541-671 1.27e-30

Clathrin heavy chain repeat homology;


Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 118.53  E-value: 1.27e-30
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2020851986   541 EPLANIDQIVDVFMENSLIQQCTSFLLDALKNNrPAEGHLQTRLLEMNLIHAPQVADAILGNqMFTHYDRAHIAQLCEKA 620
Cdd:smart00299    5 SDPIDVSEVVELFEKRNLLEELIPYLESALKLN-SENPALQTKLIELYAKYDPQKEIERLDN-KSNHYDIEKVGKLCEKA 82

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....
gi 2020851986   621 GLLQRALEHYTDLYDIKRAVVHT--HLLNPEWLVSFFGS-LSVEDSLACLHALL 671
Cdd:smart00299   83 KLYEEAVELYKKDGNFKDAIVTLieHLGNYEKAIEYFVKqNNPELWAEVLKALL 136
Clathrin pfam00637
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are ...
 1128-1267 1.61e-30

Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are composed of multiple alpha helical repeats. They occur in the arm region of the Clathrin heavy chain.


Pssm-ID: 459884 [Multi-domain]  Cd Length: 142  Bit Score: 118.13  E-value: 1.61e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2020851986 1128 YIRADDPSSYLEVVQAASRSNNWEDLVKFLQMARKKGRE--SYIETELIFALAKTGRLSELEDCINGPNNAHIQQVGDRC 1205
Cdd:pfam00637    1 LIESTDPIDVSRVVKLFEKAGLLEELISYLESALKEDSRenPALQTALIELYAKYDDPEELEEFLKKNNNYDLEKVAKLC 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2020851986 1206 YEEGMYEAAKLLYSSVSNFARLASTLVHLGEYQAAVDSSRKANSTRTWKEVCFACVDGQEFR 1267
Cdd:pfam00637   81 EKADLYEEAVILYKKIGNWKEAISLLKKLGDYKDAIEYAVKSSNPELWEELLEALLDNGRFE 142
CLH smart00299
Clathrin heavy chain repeat homology;
1128-1265 2.04e-30

Clathrin heavy chain repeat homology;


Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 117.76  E-value: 2.04e-30
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2020851986  1128 YIRADDPSSYLEVVQAASRSNNWEDLVKFLQMARKKGRE-SYIETELIFALAKTGRLSELEDCINGPNNAHIQQVGDRCY 1206
Cdd:smart00299    1 LLEVSDPIDVSEVVELFEKRNLLEELIPYLESALKLNSEnPALQTKLIELYAKYDPQKEIERLDNKSNHYDIEKVGKLCE 80

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2020851986  1207 EEGMYEAAKLLYSSVSNFARLASTLV-HLGEYQAAVDSSRKANSTRTWKEVCFACVDGQE 1265
Cdd:smart00299   81 KAKLYEEAVELYKKDGNFKDAIVTLIeHLGNYEKAIEYFVKQNNPELWAEVLKALLDKPR 140
Clathrin pfam00637
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are ...
 1274-1416 5.33e-29

Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are composed of multiple alpha helical repeats. They occur in the arm region of the Clathrin heavy chain.


Pssm-ID: 459884 [Multi-domain]  Cd Length: 142  Bit Score: 113.89  E-value: 5.33e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2020851986 1274 LHIVIHADELEELIRYYQDRGYFEELISLLEAALGL-ERAHMGMFTELAILYSKF-KPQKMPEHLELFWSrVNIPKVLRA 1351
Cdd:pfam00637    1 LIESTDPIDVSRVVKLFEKAGLLEELISYLESALKEdSRENPALQTALIELYAKYdDPEELEEFLKKNNN-YDLEKVAKL 79

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2020851986 1352 AEQAHLWAELVFLYDKYEEYDNAVLTMinHPTDAWREGQfkDVIAKVANVELYYKALQFCLDYKP 1416
Cdd:pfam00637   80 CEKADLYEEAVILYKKIGNWKEAISLL--KKLGDYKDAI--EYAVKSSNPELWEELLEALLDNGR 140
Clathrin pfam00637
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are ...
 843-970 1.30e-27

Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are composed of multiple alpha helical repeats. They occur in the arm region of the Clathrin heavy chain.


Pssm-ID: 459884 [Multi-domain]  Cd Length: 142  Bit Score: 110.04  E-value: 1.30e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2020851986  843 DELVAEVEKRNRLKLLLPWLES-RSHEGCEEPATHNALAKIYIDSN--NSPERFLRENAYYDSRVVGRYCEKRDPH-LAC 918
Cdd:pfam00637   11 SRVVKLFEKAGLLEELISYLESaLKEDSRENPALQTALIELYAKYDdpEELEEFLKKNNNYDLEKVAKLCEKADLYeEAV 90

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 2020851986  919 VAYERGQCDLELIKVCNENSLFKSEARYLVRRKDPELWAHVLEETNPSRRQL 970
Cdd:pfam00637   91 ILYKKIGNWKEAISLLKKLGDYKDAIEYAVKSSNPELWEELLEALLDNGRFE 142
CLH smart00299
Clathrin heavy chain repeat homology;
1427-1578 1.57e-26

Clathrin heavy chain repeat homology;


Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 106.59  E-value: 1.57e-26
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2020851986  1427 APRLDHTRTVGFFSKAGQLPLVKPYLRSVQSHNnkSVNEALNHLLTEEEDYQGLRASIDAYDNFdnialaqrlekHQLIE 1506
Cdd:smart00299    5 SDPIDVSEVVELFEKRNLLEELIPYLESALKLN--SENPALQTKLIELYAKYDPQKEIERLDNK-----------SNHYD 71

                            90       100       110       120       130       140       150
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2020851986  1507 FRRIAAYLYKGNNrWAQSVELCKKDHLYKDAMQHAAEsrDAELAEKLLQWFLEEGKRECFAASLFTCYDLLP 1578
Cdd:smart00299   72 IEKVGKLCEKAKL-YEEAVELYKKDGNFKDAIVTLIE--HLGNYEKAIEYFVKQNNPELWAEVLKALLDKPR 140
Clathrin pfam00637
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are ...
 688-826 2.93e-25

Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are composed of multiple alpha helical repeats. They occur in the arm region of the Clathrin heavy chain.


Pssm-ID: 459884 [Multi-domain]  Cd Length: 142  Bit Score: 103.10  E-value: 2.93e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2020851986  688 KYHEQLGTQSLVELFESFKSYEGLFYFLGSIVNFS--QDPDVHLKYIQAACKTGQIKEVERICRESNCYNAERVKNFLKE 765
Cdd:pfam00637    3 ESTDPIDVSRVVKLFEKAGLLEELISYLESALKEDsrENPALQTALIELYAKYDDPEELEEFLKKNNNYDLEKVAKLCEK 82

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2020851986  766 AKLTDQLPLIIVCdrFDFVHDLV-LYLYRNNLQKYIEIYIQKVNPSRIPAVVGGLLDVDCSE 826
Cdd:pfam00637   83 ADLYEEAVILYKK--IGNWKEAIsLLKKLGDYKDAIEYAVKSSNPELWEELLEALLDNGRFE 142
Clathrin pfam00637
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are ...
 541-667 7.76e-23

Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are composed of multiple alpha helical repeats. They occur in the arm region of the Clathrin heavy chain.


Pssm-ID: 459884 [Multi-domain]  Cd Length: 142  Bit Score: 96.17  E-value: 7.76e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2020851986  541 EPLANIDQIVDVFMENSLIQQCTSFLLDALKNNRPAEGHLQTRLLEMNLIHAP-QVADAILgnQMFTHYDRAHIAQLCEK 619
Cdd:pfam00637    5 TDPIDVSRVVKLFEKAGLLEELISYLESALKEDSRENPALQTALIELYAKYDDpEELEEFL--KKNNNYDLEKVAKLCEK 82

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 2020851986  620 AGLLQRALEHYTDLYDIKRAV-VHTHLLNPEWLVSFFGSLSVEDSLACL 667
Cdd:pfam00637   83 ADLYEEAVILYKKIGNWKEAIsLLKKLGDYKDAIEYAVKSSNPELWEEL 131
Clathrin_H_link pfam13838
Clathrin-H-link; This short domain is found on clathrins, and often appears on proteins ...
 356-421 2.87e-19

Clathrin-H-link; This short domain is found on clathrins, and often appears on proteins directly downstream from the Clathrin-link domain pfam09268.


Pssm-ID: 463995  Cd Length: 66  Bit Score: 83.41  E-value: 2.87e-19
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2020851986  356 NLAGAEELFVRKFTTLFAQGSYAEAAKVAASAPKGVLRTSDTVRKFQSIPAQPGQASPLLQYFGIL 421
Cdd:pfam13838    1 GLPGADDLYFQQFNQLLNQGDYAEAAKVAANSPRGALRTPETIQRFKQLPAQPGQLSPILQYFGTL 66
Clathrin-link pfam09268
Clathrin, heavy-chain linker; Members of this family adopt a structure consisting of ...
 331-354 8.66e-07

Clathrin, heavy-chain linker; Members of this family adopt a structure consisting of alpha-alpha superhelix. They are predominantly found in clathrin, where they act as a heavy-chain linker domain.


Pssm-ID: 462732  Cd Length: 24  Bit Score: 46.67  E-value: 8.66e-07
                           10        20
                   ....*....|....*....|....
gi 2020851986  331 EDNIVNYATSVLQNPDLGLRLAIR 354
Cdd:pfam09268    1 EDNIIPYILNTLQNPDLALRLASR 24
Clathrin_propel pfam01394
Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that ...
 296-330 1.57e-06

Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that surrounds coated vesicles. The soluble assembly unit, a triskelion, contains three heavy chains and three light chains in an extended three-legged structure. Each leg contains one heavy and one light chain. The N-terminus of the heavy chain is known as the globular domain, and is composed of seven repeats which form a beta propeller.


Pssm-ID: 460192  Cd Length: 37  Bit Score: 46.25  E-value: 1.57e-06
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 2020851986  296 NRISADTIFVTAPHESTSGIIGVN--KKGQVLSVCVE 330
Cdd:pfam01394    1 NAISAIIIFPTATMESWLFIIAINgtKKGQVQIVDVE 37
Coatomer_WDAD pfam04053
Coatomer WD associated region; This region is composed of WD40 repeats.
 1074-1185 2.09e-05

Coatomer WD associated region; This region is composed of WD40 repeats.


Pssm-ID: 427679  Cd Length: 439  Bit Score: 49.16  E-value: 2.09e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2020851986 1074 KFDVnasAIQvliehIGNLDRAYEFAERCNEPAVWSQLACAQLQKDLVKEAIDSYIRADDPS--SYLevvqaASRSNNWE 1151
Cdd:pfam04053  320 RFDL---ALE-----LGNLDVALEIAKELDDPAKWKRLGDAALSQGNIKLAEEAYQKAKDFDklLLL-----YLSTGNME 386

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 2020851986 1152 DLVKFLQMARKKGRES-----YIET----ELIFALAKTGRLSE 1185
Cdd:pfam04053  387 KLKKLAKIAEKRGDYNsafqnALYLgdveKCVDILIKTGRLPE 429
Clathrin_propel pfam01394
Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that ...
 19-55 8.92e-05

Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that surrounds coated vesicles. The soluble assembly unit, a triskelion, contains three heavy chains and three light chains in an extended three-legged structure. Each leg contains one heavy and one light chain. The N-terminus of the heavy chain is known as the globular domain, and is composed of seven repeats which form a beta propeller.


Pssm-ID: 460192  Cd Length: 37  Bit Score: 41.25  E-value: 8.92e-05
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 2020851986   19 GINPANIGFSTLTMESDKFICVREKVGeQAQVVIVDM 55
Cdd:pfam01394    1 NAISAIIIFPTATMESWLFIIAINGTK-KGQVQIVDV 36
Coatomer_WDAD_beta-like cd22947
Coatomer WD Associated Region from Coatomer Subunit Beta and Beta'; Coatomer subunit beta', ...
 1064-1185 1.02e-04

Coatomer WD Associated Region from Coatomer Subunit Beta and Beta'; Coatomer subunit beta', also called beta'-coat protein; beta'-COP; p102, is a component of the coatomer, which is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complexes are hetero-oligomers composed of at least an alpha, beta, beta', gamma, delta, epsilon and zeta subunit. It is a heptameric complex that can polymerize into a cage to deform the membrane into a bud. This model corresponds to the WD-associated (WDAD) region found in coatomer subunits beta and beta' and is composed of a beta-propeller and an alpha-solenoid. The WD40 domain is found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly. It typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40. Between the GH and WD lies a conserved core. It forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet. Each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade. The last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure. The residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands allowing them to bind either stably or reversibly.


Pssm-ID: 438572  Cd Length: 475  Bit Score: 47.08  E-value: 1.02e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2020851986 1064 LYEEAFTIFR----KFDVnasAIQvliehIGNLDRAYEFAERCNEPAVWSQLACAQLQKDLVKEAIDSYIRADDPSSYLE 1139
Cdd:cd22947    327 LKELALEVSTdpdhKFEL---ALQ-----LGDLDLALEIARESESESKWKQLGDLALSKGDFDLAEECLKKAGDLSGLLL 398

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2020851986 1140 VvqaASRSNNWEDLVKFLQMARKKGR--------------ESYIETelifaLAKTGRLSE 1185
Cdd:cd22947    399 L---YSSTGDKEGLEELAELAEAAGKnniaflayfllgdlDKCVDL-----LIKTGRLPE 450
Clathrin_propel pfam01394
Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that ...
 198-234 1.83e-04

Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that surrounds coated vesicles. The soluble assembly unit, a triskelion, contains three heavy chains and three light chains in an extended three-legged structure. Each leg contains one heavy and one light chain. The N-terminus of the heavy chain is known as the globular domain, and is composed of seven repeats which form a beta propeller.


Pssm-ID: 460192  Cd Length: 37  Bit Score: 40.48  E-value: 1.83e-04
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 2020851986  198 AAAFAEFKSEGNAKPATLFCFAVRSPTGGKLHIIEVG 234
Cdd:pfam01394    1 NAISAIIIFPTATMESWLFIIAINGTKKGQVQIVDVE 37
Clathrin_propel pfam01394
Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that ...
 256-288 5.66e-04

Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that surrounds coated vesicles. The soluble assembly unit, a triskelion, contains three heavy chains and three light chains in an extended three-legged structure. Each leg contains one heavy and one light chain. The N-terminus of the heavy chain is known as the globular domain, and is composed of seven repeats which form a beta propeller.


Pssm-ID: 460192  Cd Length: 37  Bit Score: 38.94  E-value: 5.66e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 2020851986  256 AQTDFPVAMQIGAKHGVIYLITKYGYLHMYDLE 288
Cdd:pfam01394    5 AIIIFPTATMESWLFIIAINGTKKGQVQIVDVE 37
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 1055-1219 1.01e-03

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 43.18  E-value: 1.01e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2020851986 1055 IANIAVSSALYEEAFTIFRKF----DVNASAIQVLI---EHIGNLDRAYEFAERC-----NEPAVWSQLACAQLQKDLVK 1122
Cdd:COG2956     82 LAQDYLKAGLLDRAEELLEKLleldPDDAEALRLLAeiyEQEGDWEKAIEVLERLlklgpENAHAYCELAELYLEQGDYD 161

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2020851986 1123 EAIDSYIRA-----DDPSSYLEVVQAASRSNNWEDLVKFLQMARKKGRESY-IETELIFALAKTGRLSE----LEDCI-N 1191
Cdd:COG2956    162 EAIEALEKAlkldpDCARALLLLAELYLEQGDYEEAIAALERALEQDPDYLpALPRLAELYEKLGDPEEalelLRKALeL 241

                          170       180
                   ....*....|....*....|....*...
gi 2020851986 1192 GPNNAHIQQVGDRCYEEGMYEAAKLLYS 1219
Cdd:COG2956    242 DPSDDLLLALADLLERKEGLEAALALLE 269
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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