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Conserved domains on  [gi|2020852020|ref|XP_040321066|]
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protein HIRA isoform X5 [Puma yagouaroundi]

Protein Classification

HIRA_B and Hira domain-containing protein( domain architecture ID 13236958)

protein containing domains WD40, HIRA_B, and Hira

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Hira pfam07569
TUP1-like enhancer of split; The Hira proteins are found in a range of eukaryotes and are ...
 630-816 2.09e-48

TUP1-like enhancer of split; The Hira proteins are found in a range of eukaryotes and are implicated in the assembly of repressive chromatin. These proteins also contain pfam00400.


:

Pssm-ID: 462211  Cd Length: 221  Bit Score: 171.26  E-value: 2.09e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2020852020 630 GRRLLPPILLPSPISTLHCTGSYVMALTAAATLSVWDVHRQVVVVKEESLHSILAGS---------DMTVSQILLTQHGI 700
Cdd:pfam07569   1 GRRLLPPIVLGSPASFLECSGSYLLAVTSVGLLYVWDIKKQKALLPPVSLAPLLDSSsrysdkltrAPTITSASLTSNGV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2020852020 701 PVMNLSDGKAYCFNPSLSTWNLVSDKQDSLA-QCADFRSSLPPQDAMLCSGPLAIVQ----------GRASTSGRQAARL 769
Cdd:pfam07569  81 PIVTLSNGDGYLYDKSLETWLRISDSWWALGsQYWDSTGSSRSSSQSSAAGILSFLErktneellrkGRGRLLQRLAKTL 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 2020852020 770 FSVPHVVQQET--TLAYLENQVAAALTLQSSHEYRHWLLLYARYLVNEG 816
Cdd:pfam07569 161 LMKEGFENFETvvTLAHLENRLAAALLLGSPDEYRHWLLMYAKRLAEEG 209
WD40 COG2319
WD40 repeat [General function prediction only];
3-233 2.66e-25

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 109.62  E-value: 2.66e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2020852020   3 VAWSPHDAWLASCSVDNTVVIWNAVKfPEILATLRGHSGLVKGLTWDPVGKYIASQADDRSLKVWRTLDWQLETSITkpf 82
Cdd:COG2319   126 VAFSPDGKTLASGSADGTVRLWDLAT-GKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLT--- 201

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2020852020  83 decGGTTHVLRLSWSPDGHYLVSAHAmnnsGPTAQIIEREGWKTNMDFVGHRKAVTVVKFNPkifkkkqkNGSSAkpscp 162
Cdd:COG2319   202 ---GHTGAVRSVAFSPDGKLLASGSA----DGTVRLWDLATGKLLRTLTGHSGSVRSVAFSP--------DGRLL----- 261

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2020852020 163 ycccAVGSKDRSLSVWLTCLKRPLVVIHELFDkSIMDISWTLNGLGILVCSMDGSVAFLDFSQDELGDPLS 233
Cdd:COG2319   262 ----ASGSADGTVRLWDLATGELLRTLTGHSG-GVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLT 327
Treacle super family cl25490
Treacher Collins syndrome protein Treacle;
364-583 2.05e-03

Treacher Collins syndrome protein Treacle;


The actual alignment was detected with superfamily member pfam03546:

Pssm-ID: 460967 [Multi-domain]  Cd Length: 531  Bit Score: 41.98  E-value: 2.05e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2020852020 364 NPQLLPLDSSTPNSFGASKPSTEPVATAGARP---------AGDTASKDSVNATSTPAASS---PSVLTTPSKIEPMKAF 431
Cdd:pfam03546 127 NSQVRPASTVGKGPSGKGANPAPPGKAGSAAPlvqvgkkeeDSESSSEESDSEGEAPPAATqakPSGKILQVRPASGPAK 206

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2020852020 432 DSRFTERSKATPGApaltsvTPTTVERLKEQNlvkdlrprDLLESSSDSDEKVPVAKPSSLSKRKLELEvETVEKKKKGR 511
Cdd:pfam03546 207 GAAPAPPQKAGPVA------TQVKAERSKEDS--------ESSEESSDSEEEAPAAATPAQAKPALKTP-QTKASPRKGT 271

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2020852020 512 P--RKESRLMPVSLSVQSPAALTTEKDTVCLSVPAPAlklpmPGPQRAFTLQVSSDPSMYIEVENEVTAVGGVK 583
Cdd:pfam03546 272 PitPTSAKVPPVRVGTPAPWKAGTVTSPACASSPAVA-----RGAQRPEEDSSSSEESESEEETAPAAAVGQAK 340
 
Name Accession Description Interval E-value
Hira pfam07569
TUP1-like enhancer of split; The Hira proteins are found in a range of eukaryotes and are ...
 630-816 2.09e-48

TUP1-like enhancer of split; The Hira proteins are found in a range of eukaryotes and are implicated in the assembly of repressive chromatin. These proteins also contain pfam00400.


Pssm-ID: 462211  Cd Length: 221  Bit Score: 171.26  E-value: 2.09e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2020852020 630 GRRLLPPILLPSPISTLHCTGSYVMALTAAATLSVWDVHRQVVVVKEESLHSILAGS---------DMTVSQILLTQHGI 700
Cdd:pfam07569   1 GRRLLPPIVLGSPASFLECSGSYLLAVTSVGLLYVWDIKKQKALLPPVSLAPLLDSSsrysdkltrAPTITSASLTSNGV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2020852020 701 PVMNLSDGKAYCFNPSLSTWNLVSDKQDSLA-QCADFRSSLPPQDAMLCSGPLAIVQ----------GRASTSGRQAARL 769
Cdd:pfam07569  81 PIVTLSNGDGYLYDKSLETWLRISDSWWALGsQYWDSTGSSRSSSQSSAAGILSFLErktneellrkGRGRLLQRLAKTL 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 2020852020 770 FSVPHVVQQET--TLAYLENQVAAALTLQSSHEYRHWLLLYARYLVNEG 816
Cdd:pfam07569 161 LMKEGFENFETvvTLAHLENRLAAALLLGSPDEYRHWLLMYAKRLAEEG 209
WD40 COG2319
WD40 repeat [General function prediction only];
3-233 2.66e-25

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 109.62  E-value: 2.66e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2020852020   3 VAWSPHDAWLASCSVDNTVVIWNAVKfPEILATLRGHSGLVKGLTWDPVGKYIASQADDRSLKVWRTLDWQLETSITkpf 82
Cdd:COG2319   126 VAFSPDGKTLASGSADGTVRLWDLAT-GKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLT--- 201

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2020852020  83 decGGTTHVLRLSWSPDGHYLVSAHAmnnsGPTAQIIEREGWKTNMDFVGHRKAVTVVKFNPkifkkkqkNGSSAkpscp 162
Cdd:COG2319   202 ---GHTGAVRSVAFSPDGKLLASGSA----DGTVRLWDLATGKLLRTLTGHSGSVRSVAFSP--------DGRLL----- 261

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2020852020 163 ycccAVGSKDRSLSVWLTCLKRPLVVIHELFDkSIMDISWTLNGLGILVCSMDGSVAFLDFSQDELGDPLS 233
Cdd:COG2319   262 ----ASGSADGTVRLWDLATGELLRTLTGHSG-GVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLT 327
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 1-218 3.32e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 97.79  E-value: 3.32e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2020852020   1 MDVAWSPHDAWLASCSVDNTVVIWNAVKFpEILATLRGHSGLVKGLTWDPVGKYIASQADDRSLKVWRTLDWQLETSItk 80
Cdd:cd00200    97 SSVAFSPDGRILSSSSRDKTIKVWDVETG-KCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATL-- 173

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2020852020  81 pfdecggTTH---VLRLSWSPDGHYLVSAhamnNSGPTAQIIEREGWKTNMDFVGHRKAVTVVKFNP--KIFkkkqkngs 155
Cdd:cd00200   174 -------TGHtgeVNSVAFSPDGEKLLSS----SSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPdgYLL-------- 234

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2020852020 156 sakpscpycccAVGSKDRSLSVWLTCLKRPLVVI--HElfdKSIMDISWTLNGLGILVCSMDGSV 218
Cdd:cd00200   235 -----------ASGSEDGTIRVWDLRTGECVQTLsgHT---NSVTSLAWSPDGKRLASGSADGTI 285
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 31-67 3.11e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.61  E-value: 3.11e-06
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 2020852020   31 EILATLRGHSGLVKGLTWDPVGKYIASQADDRSLKVW 67
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
31-67 2.61e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.95  E-value: 2.61e-05
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 2020852020  31 EILATLRGHSGLVKGLTWDPVGKYIASQADDRSLKVW 67
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
Treacle pfam03546
Treacher Collins syndrome protein Treacle;
364-583 2.05e-03

Treacher Collins syndrome protein Treacle;


Pssm-ID: 460967 [Multi-domain]  Cd Length: 531  Bit Score: 41.98  E-value: 2.05e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2020852020 364 NPQLLPLDSSTPNSFGASKPSTEPVATAGARP---------AGDTASKDSVNATSTPAASS---PSVLTTPSKIEPMKAF 431
Cdd:pfam03546 127 NSQVRPASTVGKGPSGKGANPAPPGKAGSAAPlvqvgkkeeDSESSSEESDSEGEAPPAATqakPSGKILQVRPASGPAK 206

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2020852020 432 DSRFTERSKATPGApaltsvTPTTVERLKEQNlvkdlrprDLLESSSDSDEKVPVAKPSSLSKRKLELEvETVEKKKKGR 511
Cdd:pfam03546 207 GAAPAPPQKAGPVA------TQVKAERSKEDS--------ESSEESSDSEEEAPAAATPAQAKPALKTP-QTKASPRKGT 271

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2020852020 512 P--RKESRLMPVSLSVQSPAALTTEKDTVCLSVPAPAlklpmPGPQRAFTLQVSSDPSMYIEVENEVTAVGGVK 583
Cdd:pfam03546 272 PitPTSAKVPPVRVGTPAPWKAGTVTSPACASSPAVA-----RGAQRPEEDSSSSEESESEEETAPAAAVGQAK 340
 
Name Accession Description Interval E-value
Hira pfam07569
TUP1-like enhancer of split; The Hira proteins are found in a range of eukaryotes and are ...
 630-816 2.09e-48

TUP1-like enhancer of split; The Hira proteins are found in a range of eukaryotes and are implicated in the assembly of repressive chromatin. These proteins also contain pfam00400.


Pssm-ID: 462211  Cd Length: 221  Bit Score: 171.26  E-value: 2.09e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2020852020 630 GRRLLPPILLPSPISTLHCTGSYVMALTAAATLSVWDVHRQVVVVKEESLHSILAGS---------DMTVSQILLTQHGI 700
Cdd:pfam07569   1 GRRLLPPIVLGSPASFLECSGSYLLAVTSVGLLYVWDIKKQKALLPPVSLAPLLDSSsrysdkltrAPTITSASLTSNGV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2020852020 701 PVMNLSDGKAYCFNPSLSTWNLVSDKQDSLA-QCADFRSSLPPQDAMLCSGPLAIVQ----------GRASTSGRQAARL 769
Cdd:pfam07569  81 PIVTLSNGDGYLYDKSLETWLRISDSWWALGsQYWDSTGSSRSSSQSSAAGILSFLErktneellrkGRGRLLQRLAKTL 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 2020852020 770 FSVPHVVQQET--TLAYLENQVAAALTLQSSHEYRHWLLLYARYLVNEG 816
Cdd:pfam07569 161 LMKEGFENFETvvTLAHLENRLAAALLLGSPDEYRHWLLMYAKRLAEEG 209
WD40 COG2319
WD40 repeat [General function prediction only];
3-233 2.66e-25

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 109.62  E-value: 2.66e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2020852020   3 VAWSPHDAWLASCSVDNTVVIWNAVKfPEILATLRGHSGLVKGLTWDPVGKYIASQADDRSLKVWRTLDWQLETSITkpf 82
Cdd:COG2319   126 VAFSPDGKTLASGSADGTVRLWDLAT-GKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLT--- 201

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2020852020  83 decGGTTHVLRLSWSPDGHYLVSAHAmnnsGPTAQIIEREGWKTNMDFVGHRKAVTVVKFNPkifkkkqkNGSSAkpscp 162
Cdd:COG2319   202 ---GHTGAVRSVAFSPDGKLLASGSA----DGTVRLWDLATGKLLRTLTGHSGSVRSVAFSP--------DGRLL----- 261

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2020852020 163 ycccAVGSKDRSLSVWLTCLKRPLVVIHELFDkSIMDISWTLNGLGILVCSMDGSVAFLDFSQDELGDPLS 233
Cdd:COG2319   262 ----ASGSADGTVRLWDLATGELLRTLTGHSG-GVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLT 327
WD40 COG2319
WD40 repeat [General function prediction only];
2-218 7.78e-24

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 104.99  E-value: 7.78e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2020852020   2 DVAWSPHDAWLASCSVDNTVVIWNaVKFPEILATLRGHSGLVKGLTWDPVGKYIASQADDRSLKVWRTLDWQLETSITkp 81
Cdd:COG2319   209 SVAFSPDGKLLASGSADGTVRLWD-LATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLT-- 285

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2020852020  82 fdecGGTTHVLRLSWSPDGHYLVSAhamnNSGPTAQIIEREGWKTNMDFVGHRKAVTVVKFNPkifkkkqkNGSSAkpsc 161
Cdd:COG2319   286 ----GHSGGVNSVAFSPDGKLLASG----SDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP--------DGKTL---- 345

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2020852020 162 pycccAVGSKDRSLSVWLTCLKRPLVVIHElFDKSIMDISWTLNGLGILVCSMDGSV 218
Cdd:COG2319   346 -----ASGSDDGTVRLWDLATGELLRTLTG-HTGAVTSVAFSPDGRTLASGSADGTV 396
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 1-218 3.32e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 97.79  E-value: 3.32e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2020852020   1 MDVAWSPHDAWLASCSVDNTVVIWNAVKFpEILATLRGHSGLVKGLTWDPVGKYIASQADDRSLKVWRTLDWQLETSItk 80
Cdd:cd00200    97 SSVAFSPDGRILSSSSRDKTIKVWDVETG-KCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATL-- 173

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2020852020  81 pfdecggTTH---VLRLSWSPDGHYLVSAhamnNSGPTAQIIEREGWKTNMDFVGHRKAVTVVKFNP--KIFkkkqkngs 155
Cdd:cd00200   174 -------TGHtgeVNSVAFSPDGEKLLSS----SSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPdgYLL-------- 234

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2020852020 156 sakpscpycccAVGSKDRSLSVWLTCLKRPLVVI--HElfdKSIMDISWTLNGLGILVCSMDGSV 218
Cdd:cd00200   235 -----------ASGSEDGTIRVWDLRTGECVQTLsgHT---NSVTSLAWSPDGKRLASGSADGTI 285
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 2-222 1.64e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 95.86  E-value: 1.64e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2020852020   2 DVAWSPHDAWLASCSVDNTVVIWNaVKFPEILATLRGHSGLVKGLTWDPVGKYIASQADDRSLKVWRTLDWQLETSITkp 81
Cdd:cd00200    56 DVAASADGTYLASGSSDKTIRLWD-LETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLR-- 132

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2020852020  82 fdecGGTTHVLRLSWSPDGHYLVSAHAMNnsgpTAQIIEREGWKTNMDFVGHRKAVTVVKFNPkifkkkqkNGSSakpsc 161
Cdd:cd00200   133 ----GHTDWVNSVAFSPDGTFVASSSQDG----TIKLWDLRTGKCVATLTGHTGEVNSVAFSP--------DGEK----- 191

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2020852020 162 pyccCAVGSKDRSLSVWLTCLKRPLVVIHElFDKSIMDISWTLNGLGILVCSMDGSVAFLD 222
Cdd:cd00200   192 ----LLSSSSDGTIKLWDLSTGKCLGTLRG-HENGVNSVAFSPDGYLLASGSEDGTIRVWD 247
WD40 COG2319
WD40 repeat [General function prediction only];
3-233 6.46e-21

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 96.52  E-value: 6.46e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2020852020   3 VAWSPHDAWLASCSVDNTVVIWNAVKfPEILATLRGHSGLVKGLTWDPVGKYIASQADDRSLKVWRTLDWQLETSITkpf 82
Cdd:COG2319    84 VAFSPDGRLLASASADGTVRLWDLAT-GLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLT--- 159

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2020852020  83 decGGTTHVLRLSWSPDGHYLVSAHamnnSGPTAQIIEREGWKTNMDFVGHRKAVTVVKFNPkifkkkqkNGSSAkpscp 162
Cdd:COG2319   160 ---GHSGAVTSVAFSPDGKLLASGS----DDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP--------DGKLL----- 219

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2020852020 163 ycccAVGSKDRSLSVW-LTclKRPLVVIHELFDKSIMDISWTLNGLGILVCSMDGSVAFLDFSQDELGDPLS 233
Cdd:COG2319   220 ----ASGSADGTVRLWdLA--TGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLT 285
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 1-238 1.29e-20

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 93.17  E-value: 1.29e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2020852020   1 MDVAWSPHDAWLASCSVDNTVVIWNaVKFPEILATLRGHSGLVKGLTWDPVGKYIASQADDRSLKVWrtlDWQLETSITK 80
Cdd:cd00200    13 TCVAFSPDGKLLATGSGDGTIKVWD-LETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLW---DLETGECVRT 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2020852020  81 PFDECGGtthVLRLSWSPDGHYLVSAHAMNnsgpTAQIIEREGWKTNMDFVGHRKAVTVVKFNPkifkkkqkNGSSAkps 160
Cdd:cd00200    89 LTGHTSY---VSSVAFSPDGRILSSSSRDK----TIKVWDVETGKCLTTLRGHTDWVNSVAFSP--------DGTFV--- 150

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2020852020 161 cpycccAVGSKDRSLSVW-LTCLKrpLVVIHELFDKSIMDISWTLNGLGILVCSMDGSVAFLDFSQDELGDPLSEEEKS 238
Cdd:cd00200   151 ------ASSSQDGTIKLWdLRTGK--CVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENG 221
WD40 COG2319
WD40 repeat [General function prediction only];
2-233 4.10e-14

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 75.33  E-value: 4.10e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2020852020   2 DVAWSPHDAWLASCSVDNTVVIWNAVKfPEILATLRGHSGLVKGLTWDPVGKYIASQADDRSLKVWRTLDWQLETSITkp 81
Cdd:COG2319    41 SLAASPDGARLAAGAGDLTLLLLDAAA-GALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLT-- 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2020852020  82 fdecGGTTHVLRLSWSPDGHYLVSAHAmnnsGPTAQIIEREGWKTNMDFVGHRKAVTVVKFNPkifkkkqkNGSSAkpsc 161
Cdd:COG2319   118 ----GHTGAVRSVAFSPDGKTLASGSA----DGTVRLWDLATGKLLRTLTGHSGAVTSVAFSP--------DGKLL---- 177

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2020852020 162 pycccAVGSKDRSLSVWLTCLKRPLVVI--HelfDKSIMDISWTLNGLGILVCSMDGSVAFLDFSQDELGDPLS 233
Cdd:COG2319   178 -----ASGSDDGTVRLWDLATGKLLRTLtgH---TGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLT 243
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 3-68 1.41e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 72.37  E-value: 1.41e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2020852020   3 VAWSPHDAWLASCSVDNTVVIWNAVKFpEILATLRGHSGLVKGLTWDPVGKYIASQADDRSLKVWR 68
Cdd:cd00200   225 VAFSPDGYLLASGSEDGTIRVWDLRTG-ECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
3-69 1.74e-13

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 73.41  E-value: 1.74e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2020852020   3 VAWSPHDAWLASCSVDNTVVIWNaVKFPEILATLRGHSGLVKGLTWDPVGKYIASQADDRSLKVWRT 69
Cdd:COG2319   336 VAFSPDGKTLASGSDDGTVRLWD-LATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDL 401
WD40 COG2319
WD40 repeat [General function prediction only];
4-233 1.93e-06

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 51.45  E-value: 1.93e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2020852020   4 AWSPHDAWLASCSVDNTVVIWNAVKfPEILATLRGHSGLVKGLTWDPVGKYIASQADDRSLKVWRTLDWQLETSITkpfd 83
Cdd:COG2319     1 ALSADGAALAAASADLALALLAAAL-GALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLL---- 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2020852020  84 ecGGTTHVLRLSWSPDGHYLVSAhamnNSGPTAQIIEREGWKTNMDFVGHRKAVTVVKFNPkifkkkqkNGSSAkpscpy 163
Cdd:COG2319    76 --GHTAAVLSVAFSPDGRLLASA----SADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSP--------DGKTL------ 135

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2020852020 164 cccAVGSKDRSLSVWLTCLKRPLVVIHElFDKSIMDISWTLNGLGILVCSMDGSVAFLDFSQDELGDPLS 233
Cdd:COG2319   136 ---ASGSADGTVRLWDLATGKLLRTLTG-HSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLT 201
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 31-67 3.11e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.61  E-value: 3.11e-06
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 2020852020   31 EILATLRGHSGLVKGLTWDPVGKYIASQADDRSLKVW 67
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
31-67 2.61e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.95  E-value: 2.61e-05
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 2020852020  31 EILATLRGHSGLVKGLTWDPVGKYIASQADDRSLKVW 67
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
COG4946 COG4946
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ...
 2-111 1.47e-04

Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];


Pssm-ID: 443973 [Multi-domain]  Cd Length: 1072  Bit Score: 45.80  E-value: 1.47e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2020852020    2 DVAWSPHDAWLASCS-VDNTVVIW----NAVKFPEILATlrGHSGLVKGLTWDPVGKYIASQADDRSLKVwrtLDwqLET 76
Cdd:COG4946    347 LPAWSPDGKSIAYFSdASGEYELYiapaDGSGEPKQLTL--GDLGRVFNPVWSPDGKKIAFTDNRGRLWV---VD--LAS 419

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 2020852020   77 SITKPFDECGGTTHVLRLSWSPDGHYLVSAHAMNN 111
Cdd:COG4946    420 GKVRKVDTDGYGDGISDLAWSPDSKWLAYSKPGPN 454
WD40 pfam00400
WD domain, G-beta repeat;
1-25 2.98e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.25  E-value: 2.98e-04
                          10        20
                  ....*....|....*....|....*
gi 2020852020   1 MDVAWSPHDAWLASCSVDNTVVIWN 25
Cdd:pfam00400  15 TSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 2-25 3.99e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.83  E-value: 3.99e-04
                           10        20
                   ....*....|....*....|....
gi 2020852020    2 DVAWSPHDAWLASCSVDNTVVIWN 25
Cdd:smart00320  17 SVAFSPDGKYLASGSDDGTIKLWD 40
Treacle pfam03546
Treacher Collins syndrome protein Treacle;
364-583 2.05e-03

Treacher Collins syndrome protein Treacle;


Pssm-ID: 460967 [Multi-domain]  Cd Length: 531  Bit Score: 41.98  E-value: 2.05e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2020852020 364 NPQLLPLDSSTPNSFGASKPSTEPVATAGARP---------AGDTASKDSVNATSTPAASS---PSVLTTPSKIEPMKAF 431
Cdd:pfam03546 127 NSQVRPASTVGKGPSGKGANPAPPGKAGSAAPlvqvgkkeeDSESSSEESDSEGEAPPAATqakPSGKILQVRPASGPAK 206

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2020852020 432 DSRFTERSKATPGApaltsvTPTTVERLKEQNlvkdlrprDLLESSSDSDEKVPVAKPSSLSKRKLELEvETVEKKKKGR 511
Cdd:pfam03546 207 GAAPAPPQKAGPVA------TQVKAERSKEDS--------ESSEESSDSEEEAPAAATPAQAKPALKTP-QTKASPRKGT 271

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2020852020 512 P--RKESRLMPVSLSVQSPAALTTEKDTVCLSVPAPAlklpmPGPQRAFTLQVSSDPSMYIEVENEVTAVGGVK 583
Cdd:pfam03546 272 PitPTSAKVPPVRVGTPAPWKAGTVTSPACASSPAVA-----RGAQRPEEDSSSSEESESEEETAPAAAVGQAK 340
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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