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Conserved domains on  [gi|2038332540|ref|XP_041435212|]
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SUN domain-containing protein 1 isoform X6 [Xenopus laevis]

Protein Classification

MRP and Sad1_UNC domain-containing protein( domain architecture ID 10291593)

MRP and Sad1_UNC domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Sad1_UNC pfam07738
Sad1 / UNC-like C-terminal; The C. elegans UNC-84 protein is a nuclear envelope protein that ...
 766-900 1.72e-47

Sad1 / UNC-like C-terminal; The C. elegans UNC-84 protein is a nuclear envelope protein that is involved in nuclear anchoring and migration during development. The S. pombe Sad1 protein localizes at the spindle pole body. UNC-84 and and Sad1 share a common C-terminal region, that is often termed the SUN (Sad1 and UNC) domain. In mammals, the SUN domain is present in two proteins, Sun1 and Sun2. The SUN domain of Sun2 has been demonstrated to be in the periplasm.


:

Pssm-ID: 400199  Cd Length: 130  Bit Score: 165.16  E-value: 1.72e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038332540 766 LWYFSQSPRVVIQPDMYPGNCWAFKGTQGFLVVRLSRMIYPTAFSIEHIPKSLsplgnITSAPKDFAIYGLDDEYQEDGQ 845
Cdd:pfam07738   1 LNYEAKPPKVILQPDYMPGPCWSFKGSRGFVVIELSEFIIVEAITLEHVEKSV-----FSSAPKDFEVSGSDRYPTTKWV 75

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2038332540 846 VLLRAMYDQEGEPLQVFHIQEDCRKPFQIVELRIFSNWGQQDFTCLYRFRAHGTP 900
Cdd:pfam07738  76 LLGEFSYDLDGKTIQTFQLENPPDIWVKYVKLRILSNYGNEHYTCLYRFRVHGTV 130
MRP super family cl09637
Mitochondrial RNA binding protein MRP; MRP1 and MRP2 are mitochondrial RNA binding proteins ...
 127-200 3.15e-07

Mitochondrial RNA binding protein MRP; MRP1 and MRP2 are mitochondrial RNA binding proteins that form a heteromeric complex. The MRP1/MRP2 heterotetrameric complex binds to guide RNAs and stabilizes them in an unfolded conformation suitable for RNA-RNA hybridization. Each MRP subunit adopts a 'whirly' transcription factor fold.


The actual alignment was detected with superfamily member pfam09387:

Pssm-ID: 430576  Cd Length: 192  Bit Score: 51.49  E-value: 3.15e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2038332540 127 ASLIReQTEVSSIWGLD----DEELMKDGNTTLIQSNGDFnsaETQTTMINGYTCSDCSIVSQRNDTLTARSASYSAS 200
Cdd:pfam09387  54 GSLIR-QTKVDHFWGLDyhlpDDGDLKGGPKAAPQGNGDR---AVSVALPNGYTARFCSVLEGRLTKHEVASGPTNRV 127
 
Name Accession Description Interval E-value
Sad1_UNC pfam07738
Sad1 / UNC-like C-terminal; The C. elegans UNC-84 protein is a nuclear envelope protein that ...
 766-900 1.72e-47

Sad1 / UNC-like C-terminal; The C. elegans UNC-84 protein is a nuclear envelope protein that is involved in nuclear anchoring and migration during development. The S. pombe Sad1 protein localizes at the spindle pole body. UNC-84 and and Sad1 share a common C-terminal region, that is often termed the SUN (Sad1 and UNC) domain. In mammals, the SUN domain is present in two proteins, Sun1 and Sun2. The SUN domain of Sun2 has been demonstrated to be in the periplasm.


Pssm-ID: 400199  Cd Length: 130  Bit Score: 165.16  E-value: 1.72e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038332540 766 LWYFSQSPRVVIQPDMYPGNCWAFKGTQGFLVVRLSRMIYPTAFSIEHIPKSLsplgnITSAPKDFAIYGLDDEYQEDGQ 845
Cdd:pfam07738   1 LNYEAKPPKVILQPDYMPGPCWSFKGSRGFVVIELSEFIIVEAITLEHVEKSV-----FSSAPKDFEVSGSDRYPTTKWV 75

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2038332540 846 VLLRAMYDQEGEPLQVFHIQEDCRKPFQIVELRIFSNWGQQDFTCLYRFRAHGTP 900
Cdd:pfam07738  76 LLGEFSYDLDGKTIQTFQLENPPDIWVKYVKLRILSNYGNEHYTCLYRFRVHGTV 130
MRP pfam09387
Mitochondrial RNA binding protein MRP; MRP1 and MRP2 are mitochondrial RNA binding proteins ...
 127-200 3.15e-07

Mitochondrial RNA binding protein MRP; MRP1 and MRP2 are mitochondrial RNA binding proteins that form a heteromeric complex. The MRP1/MRP2 heterotetrameric complex binds to guide RNAs and stabilizes them in an unfolded conformation suitable for RNA-RNA hybridization. Each MRP subunit adopts a 'whirly' transcription factor fold.


Pssm-ID: 430576  Cd Length: 192  Bit Score: 51.49  E-value: 3.15e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2038332540 127 ASLIReQTEVSSIWGLD----DEELMKDGNTTLIQSNGDFnsaETQTTMINGYTCSDCSIVSQRNDTLTARSASYSAS 200
Cdd:pfam09387  54 GSLIR-QTKVDHFWGLDyhlpDDGDLKGGPKAAPQGNGDR---AVSVALPNGYTARFCSVLEGRLTKHEVASGPTNRV 127
 
Name Accession Description Interval E-value
Sad1_UNC pfam07738
Sad1 / UNC-like C-terminal; The C. elegans UNC-84 protein is a nuclear envelope protein that ...
 766-900 1.72e-47

Sad1 / UNC-like C-terminal; The C. elegans UNC-84 protein is a nuclear envelope protein that is involved in nuclear anchoring and migration during development. The S. pombe Sad1 protein localizes at the spindle pole body. UNC-84 and and Sad1 share a common C-terminal region, that is often termed the SUN (Sad1 and UNC) domain. In mammals, the SUN domain is present in two proteins, Sun1 and Sun2. The SUN domain of Sun2 has been demonstrated to be in the periplasm.


Pssm-ID: 400199  Cd Length: 130  Bit Score: 165.16  E-value: 1.72e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038332540 766 LWYFSQSPRVVIQPDMYPGNCWAFKGTQGFLVVRLSRMIYPTAFSIEHIPKSLsplgnITSAPKDFAIYGLDDEYQEDGQ 845
Cdd:pfam07738   1 LNYEAKPPKVILQPDYMPGPCWSFKGSRGFVVIELSEFIIVEAITLEHVEKSV-----FSSAPKDFEVSGSDRYPTTKWV 75

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2038332540 846 VLLRAMYDQEGEPLQVFHIQEDCRKPFQIVELRIFSNWGQQDFTCLYRFRAHGTP 900
Cdd:pfam07738  76 LLGEFSYDLDGKTIQTFQLENPPDIWVKYVKLRILSNYGNEHYTCLYRFRVHGTV 130
MRP pfam09387
Mitochondrial RNA binding protein MRP; MRP1 and MRP2 are mitochondrial RNA binding proteins ...
 127-200 3.15e-07

Mitochondrial RNA binding protein MRP; MRP1 and MRP2 are mitochondrial RNA binding proteins that form a heteromeric complex. The MRP1/MRP2 heterotetrameric complex binds to guide RNAs and stabilizes them in an unfolded conformation suitable for RNA-RNA hybridization. Each MRP subunit adopts a 'whirly' transcription factor fold.


Pssm-ID: 430576  Cd Length: 192  Bit Score: 51.49  E-value: 3.15e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2038332540 127 ASLIReQTEVSSIWGLD----DEELMKDGNTTLIQSNGDFnsaETQTTMINGYTCSDCSIVSQRNDTLTARSASYSAS 200
Cdd:pfam09387  54 GSLIR-QTKVDHFWGLDyhlpDDGDLKGGPKAAPQGNGDR---AVSVALPNGYTARFCSVLEGRLTKHEVASGPTNRV 127
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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