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Conserved domains on  [gi|2082462442|ref|XP_042947647|]
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uncharacterized WD repeat-containing protein C2A9.03-like isoform X1 [Carya illinoinensis]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
243-426 2.05e-24

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 104.61  E-value: 2.05e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082462442 243 SSSGAIHFTASNnDCGVRDFDMEKFQLSKHFR-FPWPVNHTSLSPDGKLLIVVGDnpDGTMV--DSQTGKAVMPLCGHLD 319
Cdd:COG2319   171 SPDGKLLASGSD-DGTVRLWDLATGKLLRTLTgHTGAVRSVAFSPDGKLLASGSA--DGTVRlwDLATGKLLRTLTGHSG 247

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082462442 320 FSFASAWHPNGVTFATGNQDKTCRVWDVRNlSKSVAILKGNLGAIRSIRYTSDGRYMAIAEPADFVHVYDVKSGYEKEQE 399
Cdd:COG2319   248 SVRSVAFSPDGRLLASGSADGTVRLWDLAT-GELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTL 326

                         170       180
                  ....*....|....*....|....*..
gi 2082462442 400 IDFFGEVSGISFSPDTESLFIGVWDRT 426
Cdd:COG2319   327 TGHTGAVRSVAFSPDGKTLASGSDDGT 353
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
243-426 2.05e-24

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 104.61  E-value: 2.05e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082462442 243 SSSGAIHFTASNnDCGVRDFDMEKFQLSKHFR-FPWPVNHTSLSPDGKLLIVVGDnpDGTMV--DSQTGKAVMPLCGHLD 319
Cdd:COG2319   171 SPDGKLLASGSD-DGTVRLWDLATGKLLRTLTgHTGAVRSVAFSPDGKLLASGSA--DGTVRlwDLATGKLLRTLTGHSG 247

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082462442 320 FSFASAWHPNGVTFATGNQDKTCRVWDVRNlSKSVAILKGNLGAIRSIRYTSDGRYMAIAEPADFVHVYDVKSGYEKEQE 399
Cdd:COG2319   248 SVRSVAFSPDGRLLASGSADGTVRLWDLAT-GELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTL 326

                         170       180
                  ....*....|....*....|....*..
gi 2082462442 400 IDFFGEVSGISFSPDTESLFIGVWDRT 426
Cdd:COG2319   327 TGHTGAVRSVAFSPDGKTLASGSDDGT 353
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 278-426 7.19e-18

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 83.54  E-value: 7.19e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082462442 278 PVNHTSLSPDGKLLIVVGDnpDGT--MVDSQTGKAVMPLCGHLDFSFASAWHPNGVTFATGNQDKTCRVWDVRNlSKSVA 355
Cdd:cd00200    53 PVRDVAASADGTYLASGSS--DKTirLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVET-GKCLT 129

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2082462442 356 ILKGNLGAIRSIRYTSDGRYMAIAEPADFVHVYDVKSGYEKEQEIDFFGEVSGISFSPDTESLFIGVWDRT 426
Cdd:cd00200   130 TLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGT 200
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 307-346 1.59e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.83  E-value: 1.59e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 2082462442  307 TGKAVMPLCGHLDFSFASAWHPNGVTFATGNQDKTCRVWD 346
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
308-346 2.33e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.78  E-value: 2.33e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 2082462442 308 GKAVMPLCGHLDFSFASAWHPNGVTFATGNQDKTCRVWD 346
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
243-426 2.05e-24

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 104.61  E-value: 2.05e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082462442 243 SSSGAIHFTASNnDCGVRDFDMEKFQLSKHFR-FPWPVNHTSLSPDGKLLIVVGDnpDGTMV--DSQTGKAVMPLCGHLD 319
Cdd:COG2319   171 SPDGKLLASGSD-DGTVRLWDLATGKLLRTLTgHTGAVRSVAFSPDGKLLASGSA--DGTVRlwDLATGKLLRTLTGHSG 247

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082462442 320 FSFASAWHPNGVTFATGNQDKTCRVWDVRNlSKSVAILKGNLGAIRSIRYTSDGRYMAIAEPADFVHVYDVKSGYEKEQE 399
Cdd:COG2319   248 SVRSVAFSPDGRLLASGSADGTVRLWDLAT-GELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTL 326

                         170       180
                  ....*....|....*....|....*..
gi 2082462442 400 IDFFGEVSGISFSPDTESLFIGVWDRT 426
Cdd:COG2319   327 TGHTGAVRSVAFSPDGKTLASGSDDGT 353
WD40 COG2319
WD40 repeat [General function prediction only];
277-426 4.23e-22

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 97.67  E-value: 4.23e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082462442 277 WPVNHTSLSPDGKLLIVVGDnpDGT--MVDSQTGKAVMPLCGHLDFSFASAWHPNGVTFATGNQDKTCRVWDVRNlSKSV 354
Cdd:COG2319   247 GSVRSVAFSPDGRLLASGSA--DGTvrLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLAT-GKLL 323

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2082462442 355 AILKGNLGAIRSIRYTSDGRYMAIAEPADFVHVYDVKSGYEKEQEIDFFGEVSGISFSPDTESLFIGVWDRT 426
Cdd:COG2319   324 RTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGT 395
WD40 COG2319
WD40 repeat [General function prediction only];
277-426 1.25e-19

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 90.36  E-value: 1.25e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082462442 277 WPVNHTSLSPDGKLLIVVGDNPDGTMVDSQTGKAVMPLCGHLDFSFASAWHPNGVTFATGNQDKTCRVWDVRNlSKSVAI 356
Cdd:COG2319    79 AAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLAT-GKLLRT 157

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2082462442 357 LKGNLGAIRSIRYTSDGRYMAIAEPADFVHVYDVKSGyekeQEIDFF----GEVSGISFSPDTESLFIGVWDRT 426
Cdd:COG2319   158 LTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATG----KLLRTLtghtGAVRSVAFSPDGKLLASGSADGT 227
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 278-426 7.19e-18

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 83.54  E-value: 7.19e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082462442 278 PVNHTSLSPDGKLLIVVGDnpDGT--MVDSQTGKAVMPLCGHLDFSFASAWHPNGVTFATGNQDKTCRVWDVRNlSKSVA 355
Cdd:cd00200    53 PVRDVAASADGTYLASGSS--DKTirLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVET-GKCLT 129

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2082462442 356 ILKGNLGAIRSIRYTSDGRYMAIAEPADFVHVYDVKSGYEKEQEIDFFGEVSGISFSPDTESLFIGVWDRT 426
Cdd:cd00200   130 TLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGT 200
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 250-426 1.19e-17

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 82.77  E-value: 1.19e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082462442 250 FTASNNDCGVRDFDMEKFQLSKHFRFPW-PVNHTSLSPDGKLLIVVGDnpDGTM--VDSQTGKAVMPLCGHLDFSFASAW 326
Cdd:cd00200   108 LSSSSRDKTIKVWDVETGKCLTTLRGHTdWVNSVAFSPDGTFVASSSQ--DGTIklWDLRTGKCVATLTGHTGEVNSVAF 185

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082462442 327 HPNGVTFATGNQDKTCRVWDVRNlSKSVAILKGNLGAIRSIRYTSDGRYMAIAEPADFVHVYDVKSGYEKEQEIDFFGEV 406
Cdd:cd00200   186 SPDGEKLLSSSSDGTIKLWDLST-GKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSV 264

                         170       180
                  ....*....|....*....|
gi 2082462442 407 SGISFSPDTESLFIGVWDRT 426
Cdd:cd00200   265 TSLAWSPDGKRLASGSADGT 284
WD40 COG2319
WD40 repeat [General function prediction only];
278-392 2.85e-15

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 77.26  E-value: 2.85e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082462442 278 PVNHTSLSPDGKLLIVVGDnpDGT--MVDSQTGKAVMPLCGHLDFSFASAWHPNGVTFATGNQDKTCRVWDVRNlSKSVA 355
Cdd:COG2319   290 GVNSVAFSPDGKLLASGSD--DGTvrLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLAT-GELLR 366

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 2082462442 356 ILKGNLGAIRSIRYTSDGRYMAIAEPADFVHVYDVKS 392
Cdd:COG2319   367 TLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
268-426 6.54e-14

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 73.02  E-value: 6.54e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082462442 268 QLSKHFRFPWPVNHTSLSPDGKLLIVVGDNPDGTMVDSQTGKAVMPLCGHLDFSFASAWHPNGVTFATGNQDKTCRVWDV 347
Cdd:COG2319    28 LLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDL 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082462442 348 RNlSKSVAILKGNLGAIRSIRYTSDGRYMAIAEPADFVHVYDVKSGyekeQEIDFF----GEVSGISFSPDTESLFIGVW 423
Cdd:COG2319   108 AT-GLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATG----KLLRTLtghsGAVTSVAFSPDGKLLASGSD 182


                  ...
gi 2082462442 424 DRT 426
Cdd:COG2319   183 DGT 185
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 184-389 1.99e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 70.44  E-value: 1.99e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082462442 184 LEGFSQTqVSTLAV--KDKLLVTGGFQGELICKHLDRPGvsfCSRTTYDDNAITNAVEIyaSSSGAIHFTASNNDCgVRD 261
Cdd:cd00200    89 LTGHTSY-VSSVAFspDGRILSSSSRDKTIKVWDVETGK---CLTTLRGHTDWVNSVAF--SPDGTFVASSSQDGT-IKL 161

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082462442 262 FDMEKFQLSKHFRFP-WPVNHTSLSPDGKLLIVVGDnpDGT--MVDSQTGKAVMPLCGHLDFSFASAWHPNGVTFATGNQ 338
Cdd:cd00200   162 WDLRTGKCVATLTGHtGEVNSVAFSPDGEKLLSSSS--DGTikLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSE 239

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2082462442 339 DKTCRVWDVRNLsKSVAILKGNLGAIRSIRYTSDGRYMAIAEPADFVHVYD 389
Cdd:cd00200   240 DGTIRVWDLRTG-ECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 278-426 2.29e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 70.44  E-value: 2.29e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082462442 278 PVNHTSLSPDGKLLIVVGDnpDGT--MVDSQTGKAVMPLCGHLDFSFASAWHPNGVTFATGNQDKTCRVWDVRNlSKSVA 355
Cdd:cd00200    11 GVTCVAFSPDGKLLATGSG--DGTikVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLET-GECVR 87

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2082462442 356 ILKGNLGAIRSIRYTSDGRYMAIAEPADFVHVYDVKSGYEKEQEIDFFGEVSGISFSPDTESLFIGVWDRT 426
Cdd:cd00200    88 TLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGT 158
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 316-426 2.73e-11

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 63.89  E-value: 2.73e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082462442 316 GHLDFSFASAWHPNGVTFATGNQDKTCRVWDVRNLSKsVAILKGNLGAIRSIRYTSDGRYMAIAEPADFVHVYDVKSGYE 395
Cdd:cd00200     7 GHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGEL-LRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGEC 85

                          90       100       110
                  ....*....|....*....|....*....|.
gi 2082462442 396 KEQEIDFFGEVSGISFSPDTESLFIGVWDRT 426
Cdd:cd00200    86 VRTLTGHTSYVSSVAFSPDGRILSSSSRDKT 116
WD40 COG2319
WD40 repeat [General function prediction only];
283-426 4.11e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 58.38  E-value: 4.11e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082462442 283 SLSPDGKLLIVVGDNPDGTMVDSQTGKAVMPLCGHLDFSFASAWHPNGVTFATGNQDKTCRVWDVRNlSKSVAILKGNLG 362
Cdd:COG2319     1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAA-GALLATLLGHTA 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2082462442 363 AIRSIRYTSDGRYMAIAEPADFVHVYDVKSGYEKEQEIDFFGEVSGISFSPDTESLFIGVWDRT 426
Cdd:COG2319    80 AVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGT 143
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 307-346 1.59e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.83  E-value: 1.59e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 2082462442  307 TGKAVMPLCGHLDFSFASAWHPNGVTFATGNQDKTCRVWD 346
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
308-346 2.33e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.78  E-value: 2.33e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 2082462442 308 GKAVMPLCGHLDFSFASAWHPNGVTFATGNQDKTCRVWD 346
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
286-420 3.59e-03

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 38.91  E-value: 3.59e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082462442 286 PDGKLLIVVGDNPDG-TMVDSQTGKAVMplcghldfSFASAWHPNGVTFATGNQdktcRVWDVRNLSKSVAILKGNLGAI 364
Cdd:COG3391    77 ADGRRLYVANSGSGRvSVIDLATGKVVA--------TIPVGGGPRGLAVDPDGG----RLYVADSGNGRVSVIDTATGKV 144

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2082462442 365 ----------RSIRYTSDGRYMAIAEPAD-----FVHVYDVKSGyEKEQEIDFFGEVSGISFSPDTESLFI 420
Cdd:COG3391   145 vatipvgagpHGIAVDPDGKRLYVANSGSntvsvIVSVIDTATG-KVVATIPVGGGPVGVAVSPDGRRLYV 214
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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