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Conserved domains on  [gi|2093742949|ref|XP_043504765|]
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craniofacial development protein 2-like [Polistes fuscatus]

Protein Classification

exonuclease/endonuclease/phosphatase family protein( domain architecture ID 662)

exonuclease/endonuclease/phosphatase (EEP) family protein may cleave phosphodiester bonds

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
EEP super family cl00490
Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; This large superfamily includes ...
 1-228 3.05e-25

Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; This large superfamily includes the catalytic domain (exonuclease/endonuclease/phosphatase or EEP domain) of a diverse set of proteins including the ExoIII family of apurinic/apyrimidinic (AP) endonucleases, inositol polyphosphate 5-phosphatases (INPP5), neutral sphingomyelinases (nSMases), deadenylases (such as the vertebrate circadian-clock regulated nocturnin), bacterial cytolethal distending toxin B (CdtB), deoxyribonuclease 1 (DNase1), the endonuclease domain of the non-LTR retrotransposon LINE-1, and related domains. These diverse enzymes share a common catalytic mechanism of cleaving phosphodiester bonds; their substrates range from nucleic acids to phospholipids and perhaps proteins.


The actual alignment was detected with superfamily member cd09076:

Pssm-ID: 469791 [Multi-domain]  Cd Length: 236  Bit Score: 99.73  E-value: 3.05e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2093742949   1 MDEVILELKNMKVDIAVVTEIKKKGQGSQKLGYYDHF--YSGVPKHIRAqqGVSIFI-HRTLRKHITSWEAINERMIKVN 77
Cdd:cd09076    15 RAQLLEELKRKKLDILGLQETHWTGEGELKKKREGGTilYSGSDSGKSR--GVAILLsKTAANKLLEYTKVVSGRIIMVR 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2093742949  78 MNIYGYRTTILGVYGVNEDALvANKDEFYEQLNDEIVKVGNTREIILLGDLNGRTGNKKqddvVGRYGEEMLNDNGTK-- 155
Cdd:cd09076    93 FKIKGKRLTIINVYAPTARDE-EEKEEFYDQLQDVLDKVPRHDTLIIGGDFNAVLGPKD----DGRKGLDKRNENGERal 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2093742949 156 --------IINMCKQNNLRimsgffqhrcIHKYTRTQPTMNQESIIDYLLIKQRSRMKIndVRVYRGATCGSDYHLLKAK 227
Cdd:cd09076   168 salieehdLVDVWRENNPK----------TREYTWRSPDHGSRSRIDRILVSKRLRVKV--KKTKITPGAGSDHRLVTLK 235


                  .
gi 2093742949 228 I 228
Cdd:cd09076   236 L 236
 
Name Accession Description Interval E-value
L1-EN cd09076
Endonuclease domain (L1-EN) of the non-LTR retrotransposon LINE-1 (L1), and related domains; ...
 1-228 3.05e-25

Endonuclease domain (L1-EN) of the non-LTR retrotransposon LINE-1 (L1), and related domains; This family contains the endonuclease domain (L1-EN) of the non-LTR retrotransposon LINE-1 (L1), and related domains, including the endonuclease of Xenopus laevis Tx1. These retrotranspons belong to the subtype 2, L1-clade. LINES can be classified into two subtypes. Subtype 2 has two ORFs: the second (ORF2) encodes a modular protein consisting of an N-terminal apurine/apyrimidine endonuclease domain (EN), a central reverse transcriptase, and a zinc-finger-like domain at the C-terminus. LINE-1/L1 elements (full length and truncated) comprise about 17% of the human genome. This endonuclease nicks the genomic DNA at the consensus target sequence 5'TTTT-AA3' producing a ribose 3'-hydroxyl end as a primer for reverse transcription of associated template RNA. This subgroup also includes the endonuclease of Xenopus laevis Tx1, another member of the L1-clade. This family belongs to the large EEP (exonuclease/endonuclease/phosphatase) superfamily that contains functionally diverse enzymes that share a common catalytic mechanism of cleaving phosphodiester bonds.


Pssm-ID: 197310 [Multi-domain]  Cd Length: 236  Bit Score: 99.73  E-value: 3.05e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2093742949   1 MDEVILELKNMKVDIAVVTEIKKKGQGSQKLGYYDHF--YSGVPKHIRAqqGVSIFI-HRTLRKHITSWEAINERMIKVN 77
Cdd:cd09076    15 RAQLLEELKRKKLDILGLQETHWTGEGELKKKREGGTilYSGSDSGKSR--GVAILLsKTAANKLLEYTKVVSGRIIMVR 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2093742949  78 MNIYGYRTTILGVYGVNEDALvANKDEFYEQLNDEIVKVGNTREIILLGDLNGRTGNKKqddvVGRYGEEMLNDNGTK-- 155
Cdd:cd09076    93 FKIKGKRLTIINVYAPTARDE-EEKEEFYDQLQDVLDKVPRHDTLIIGGDFNAVLGPKD----DGRKGLDKRNENGERal 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2093742949 156 --------IINMCKQNNLRimsgffqhrcIHKYTRTQPTMNQESIIDYLLIKQRSRMKIndVRVYRGATCGSDYHLLKAK 227
Cdd:cd09076   168 salieehdLVDVWRENNPK----------TREYTWRSPDHGSRSRIDRILVSKRLRVKV--KKTKITPGAGSDHRLVTLK 235


                  .
gi 2093742949 228 I 228
Cdd:cd09076   236 L 236
Exo_endo_phos pfam03372
Endonuclease/Exonuclease/phosphatase family; This large family of proteins includes magnesium ...
 1-129 1.60e-04

Endonuclease/Exonuclease/phosphatase family; This large family of proteins includes magnesium dependent endonucleases and a large number of phosphatases involved in intracellular signalling. This family includes: AP endonuclease proteins EC:4.2.99.18, DNase I proteins EC:3.1.21.1, Synaptojanin an inositol-1,4,5-trisphosphate phosphatase EC:3.1.3.56, Sphingomyelinase EC:3.1.4.12 and Nocturnin.


Pssm-ID: 460902 [Multi-domain]  Cd Length: 183  Bit Score: 41.44  E-value: 1.60e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2093742949   1 MDEVILELKNMKVDIAVVTEIKKKGQGSQKL---GYYDHFYSGVPKHIRAQQGVSIFIHRTLRKHITSWEAINERMIKVN 77
Cdd:pfam03372  19 LDALAALIRAYDPDVVALQETDDDDASRLLLallAYGGFLSYGGPGGGGGGGGVAILSRYPLSSVILVDLGEFGDPALRG 98

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2093742949  78 MNIYGYRTTILGVYGVNE---DALVANKDEFYEQLNDEIVK-VGNTREIILLGDLN 129
Cdd:pfam03372  99 AIAPFAGVLVVPLVLTLAphaSPRLARDEQRADLLLLLLALlAPRSEPVILAGDFN 154
 
Name Accession Description Interval E-value
L1-EN cd09076
Endonuclease domain (L1-EN) of the non-LTR retrotransposon LINE-1 (L1), and related domains; ...
 1-228 3.05e-25

Endonuclease domain (L1-EN) of the non-LTR retrotransposon LINE-1 (L1), and related domains; This family contains the endonuclease domain (L1-EN) of the non-LTR retrotransposon LINE-1 (L1), and related domains, including the endonuclease of Xenopus laevis Tx1. These retrotranspons belong to the subtype 2, L1-clade. LINES can be classified into two subtypes. Subtype 2 has two ORFs: the second (ORF2) encodes a modular protein consisting of an N-terminal apurine/apyrimidine endonuclease domain (EN), a central reverse transcriptase, and a zinc-finger-like domain at the C-terminus. LINE-1/L1 elements (full length and truncated) comprise about 17% of the human genome. This endonuclease nicks the genomic DNA at the consensus target sequence 5'TTTT-AA3' producing a ribose 3'-hydroxyl end as a primer for reverse transcription of associated template RNA. This subgroup also includes the endonuclease of Xenopus laevis Tx1, another member of the L1-clade. This family belongs to the large EEP (exonuclease/endonuclease/phosphatase) superfamily that contains functionally diverse enzymes that share a common catalytic mechanism of cleaving phosphodiester bonds.


Pssm-ID: 197310 [Multi-domain]  Cd Length: 236  Bit Score: 99.73  E-value: 3.05e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2093742949   1 MDEVILELKNMKVDIAVVTEIKKKGQGSQKLGYYDHF--YSGVPKHIRAqqGVSIFI-HRTLRKHITSWEAINERMIKVN 77
Cdd:cd09076    15 RAQLLEELKRKKLDILGLQETHWTGEGELKKKREGGTilYSGSDSGKSR--GVAILLsKTAANKLLEYTKVVSGRIIMVR 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2093742949  78 MNIYGYRTTILGVYGVNEDALvANKDEFYEQLNDEIVKVGNTREIILLGDLNGRTGNKKqddvVGRYGEEMLNDNGTK-- 155
Cdd:cd09076    93 FKIKGKRLTIINVYAPTARDE-EEKEEFYDQLQDVLDKVPRHDTLIIGGDFNAVLGPKD----DGRKGLDKRNENGERal 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2093742949 156 --------IINMCKQNNLRimsgffqhrcIHKYTRTQPTMNQESIIDYLLIKQRSRMKIndVRVYRGATCGSDYHLLKAK 227
Cdd:cd09076   168 salieehdLVDVWRENNPK----------TREYTWRSPDHGSRSRIDRILVSKRLRVKV--KKTKITPGAGSDHRLVTLK 235


                  .
gi 2093742949 228 I 228
Cdd:cd09076   236 L 236
Exo_endo_phos pfam03372
Endonuclease/Exonuclease/phosphatase family; This large family of proteins includes magnesium ...
 1-129 1.60e-04

Endonuclease/Exonuclease/phosphatase family; This large family of proteins includes magnesium dependent endonucleases and a large number of phosphatases involved in intracellular signalling. This family includes: AP endonuclease proteins EC:4.2.99.18, DNase I proteins EC:3.1.21.1, Synaptojanin an inositol-1,4,5-trisphosphate phosphatase EC:3.1.3.56, Sphingomyelinase EC:3.1.4.12 and Nocturnin.


Pssm-ID: 460902 [Multi-domain]  Cd Length: 183  Bit Score: 41.44  E-value: 1.60e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2093742949   1 MDEVILELKNMKVDIAVVTEIKKKGQGSQKL---GYYDHFYSGVPKHIRAQQGVSIFIHRTLRKHITSWEAINERMIKVN 77
Cdd:pfam03372  19 LDALAALIRAYDPDVVALQETDDDDASRLLLallAYGGFLSYGGPGGGGGGGGVAILSRYPLSSVILVDLGEFGDPALRG 98

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2093742949  78 MNIYGYRTTILGVYGVNE---DALVANKDEFYEQLNDEIVK-VGNTREIILLGDLN 129
Cdd:pfam03372  99 AIAPFAGVLVVPLVLTLAphaSPRLARDEQRADLLLLLLALlAPRSEPVILAGDFN 154
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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