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Conserved domains on  [gi|2178034425|ref|XP_045739485|]
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neurogenic locus notch homolog protein 1 isoform X1 [Mirounga angustirostris]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
JMTM_Notch1 cd21702
juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein ...
1720-1799 4.09e-49

juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein 1 (Notch1) and similar proteins; Neurogenic locus notch homolog protein 1 (Notch1), also called translocation-associated notch protein TAN-1, functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. It affects the implementation of differentiation, proliferation and apoptotic programs. It is also involved in angiogenesis, and also negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. This model corresponds to the juxtamembrane and transmembrane (JMTM) domain of Notch1, which comprises an extended coil, a transmembrane helix (TM), and a beta-strand.


:

Pssm-ID: 411985  Cd Length: 80  Bit Score: 169.20  E-value: 4.09e-49
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178034425 1720 AVQSETVEPPPPPQLHFMYVAVAAFVLLFFVGCGVLLSRKRRRQHGQLWFPEGFKVSEASKKKRREPLGEDSVGLKPLKN 1799
Cdd:cd21702      1 AVKSETVEPPPPSQLYPMYVVLAALVLLAFVGVGVLVSRKRRREHGQLWFPEGFKVSEPSKKKRREPVGEDSVGLKPLKN 80
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1904-2118 4.81e-37

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 142.79  E-value: 4.81e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178034425 1904 EDAPAVISDFIYQGASLHNQTDRTGETALHLAARYSRSDAAKRLLEASADANIQDNMGRTPLHAAVSADAQGVFQILIRN 1983
Cdd:COG0666     63 LAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEA 142
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178034425 1984 RAtDLDARMHDGTTPLILAARLAVEGMLEDLINSHADVNAVDDLGKSALHWAAAVNNVEAAVVLLKNGANKDMQNNKEET 2063
Cdd:COG0666    143 GA-DVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKT 221
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2178034425 2064 PLFLAAREGSYETAKVLLDHFANRDITDHMDRLPRDIAQERMHHDIVRLLDEYSL 2118
Cdd:COG0666    222 ALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALL 276
NOD pfam06816
NOTCH protein; NOTCH signalling plays a fundamental role during a great number of ...
1567-1622 4.34e-27

NOTCH protein; NOTCH signalling plays a fundamental role during a great number of developmental processes in multicellular animals. NOD and NODP represent a region present in many NOTCH proteins and NOTCH homologs in multiple species such as NOTCH2 and NOTCH3, LIN12, SC1 and TAN1. Role of NOD domain remains to be elucidated.


:

Pssm-ID: 462014  Cd Length: 56  Bit Score: 105.67  E-value: 4.34e-27
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2178034425 1567 PERLAAGALVLVVLTPPAQLRNNSLHFLRELSRLLHTNVVFKRDAHGQPMIFPYYG 1622
Cdd:pfam06816    1 PEKLAEGVLVIVVLMDPEELLNNSVQFLRELSTVLRTNVRFKKDENGNPMIYPWYG 56
NODP pfam07684
NOTCH protein; NOTCH signalling plays a fundamental role during a great number of ...
1671-1729 3.31e-24

NOTCH protein; NOTCH signalling plays a fundamental role during a great number of developmental processes in multicellular animals. NOD and NODP represent a region present in many NOTCH proteins and NOTCH homologs in multiple species such as NOTCH2 and NOTCH3, LIN12, SC1 and TAN1. The role of the NOD and NODP domains remains to be elucidated.


:

Pssm-ID: 462229  Cd Length: 59  Bit Score: 97.34  E-value: 3.31e-24
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 2178034425 1671 IRGSIVYLEIDNRQCVQSSSQCFQSATDVAAFLGALASLGSLNIPYKIEAVQSETVEPP 1729
Cdd:pfam07684    1 VIGSVVYLEIDNRKCSQSSDECFSTAQSAADFLAALAAKGGLDLPYPIKEVRSEPPPPP 59
Notch pfam00066
LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch ...
1488-1523 1.06e-08

LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch related proteins. The structure of the domain has been determined by NMR and was shown to contain three disulphide bonds and coordinate a calcium ion. Three repeats are also found in the PAPP-A peptidase.


:

Pssm-ID: 459658  Cd Length: 35  Bit Score: 52.53  E-value: 1.06e-08
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 2178034425 1488 WQNCSQSlQCWKYFSNGRCDSQCNSVGCLFDGFDCQ 1523
Cdd:pfam00066    1 WPNCPYP-YCWDKFGNGVCDEECNNAECLWDGGDCS 35
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
679-714 1.86e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 52.25  E-value: 1.86e-08
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 2178034425  679 NIDECA-GNPCHHGGTCEDGVNSFTCRCPEGYHGPTC 714
Cdd:cd00054      1 DIDECAsGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
870-906 2.19e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 51.87  E-value: 2.19e-08
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2178034425  870 DINECV-KSPCRNGASCQNTNGGYRCRCRAGYTGHNCE 906
Cdd:cd00054      1 DIDECAsGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
NL smart00004
Domain found in Notch and Lin-12; The Notch protein is essential for the proper ...
1522-1562 2.64e-08

Domain found in Notch and Lin-12; The Notch protein is essential for the proper differentiation of the Drosophila ectoderm. This protein contains 3 NL domains.


:

Pssm-ID: 197463  Cd Length: 38  Bit Score: 51.56  E-value: 2.64e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 2178034425  1522 CQRAEGQCNplyDQYCKDHFGDGHCDQGCNSAECEWDGLDC 1562
Cdd:smart00004    1 PQDPWSRCE---DAQCWDKFGDGVCDEECNNAECLWDGGDC 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
413-451 3.48e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 51.48  E-value: 3.48e-08
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 2178034425  413 DVDECSLGaNPCEHAGKCINTLGSFECQCLQGYTGPRCE 451
Cdd:cd00054      1 DIDECASG-NPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
529-565 9.17e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 50.33  E-value: 9.17e-08
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2178034425  529 DVDECAST-PCKNGAKCLDGPNTYTCVCTEGYTGPHCE 565
Cdd:cd00054      1 DIDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
1022-1058 9.91e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 49.94  E-value: 9.91e-08
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2178034425 1022 DVNECDSR-PCLHGGTCQDSYGTYKCTCPQGYTGLNCQ 1058
Cdd:cd00054      1 DIDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
946-982 1.22e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 49.94  E-value: 1.22e-07
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2178034425  946 DINECAS-NPCRHGANCTDCVDSYTCTCPAGFSGIHCE 982
Cdd:cd00054      1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
1147-1181 2.11e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 49.17  E-value: 2.11e-07
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 2178034425 1147 VDEC-SPSPCQNGATCTDYPGGYSCECVAGYHGVNC 1181
Cdd:cd00054      2 IDECaSGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
NL smart00004
Domain found in Notch and Lin-12; The Notch protein is essential for the proper ...
1443-1480 2.77e-07

Domain found in Notch and Lin-12; The Notch protein is essential for the proper differentiation of the Drosophila ectoderm. This protein contains 3 NL domains.


:

Pssm-ID: 197463  Cd Length: 38  Bit Score: 48.86  E-value: 2.77e-07
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 2178034425  1443 PPQIEEACELPECREEAGNKVCSLACNNHACGWDGGDC 1480
Cdd:smart00004    1 PQDPWSRCEDAQCWDKFGDGVCDEECNNAECLWDGGDC 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
179-217 4.14e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 48.40  E-value: 4.14e-07
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 2178034425  179 DVNECSQNPrLCQNGGTCHNEVGSYRCTCRTTHTGPHCE 217
Cdd:cd00054      1 DIDECASGN-PCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
296-333 4.90e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 48.02  E-value: 4.90e-07
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2178034425  296 DVDECQlMPNACQNGGTCHNSHGGYNCVCVNGWTGEDC 333
Cdd:cd00054      1 DIDECA-SGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
453-489 7.24e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 47.63  E-value: 7.24e-07
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2178034425  453 DVNEC-ISNPCQNEATCLDQIGEFQCICMPGYEGVHCE 489
Cdd:cd00054      1 DIDECaSGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
792-828 1.59e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.48  E-value: 1.59e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2178034425  792 NINECAS-NPCLNQGSCIDDVAGYKCNCPLPYTGATCE 828
Cdd:cd00054      1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
1185-1220 2.11e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.48  E-value: 2.11e-06
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 2178034425 1185 INECVSQ-PCQNGGTCIDLTNTYKCSCPRGTQGVHCE 1220
Cdd:cd00054      2 IDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
1230-1266 3.84e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 45.71  E-value: 3.84e-06
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 2178034425 1230 IDPVSRGPKCFNNGTCVDQVGGYSCTCPPGFVGERCE 1266
Cdd:cd00054      2 IDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
908-944 8.83e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.55  E-value: 8.83e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2178034425  908 DVDDCR-PNPCHNGGSCTDGVNTAFCDCLPGFRGPFCE 944
Cdd:cd00054      1 DIDECAsGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
989-1020 1.20e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.16  E-value: 1.20e-05
                           10        20        30
                   ....*....|....*....|....*....|..
gi 2178034425  989 TESSCFNGGTCVDGINSFTCLCPPGFTGSYCQ 1020
Cdd:cd00054      7 SGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
756-790 3.04e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.01  E-value: 3.04e-05
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 2178034425  756 DECES-NPCANGGACRDMTSGYVCTCREGFSGPNCQ 790
Cdd:cd00054      3 DECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
567-602 3.29e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.01  E-value: 3.29e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2178034425  567 DIDECD-PDPCHY-GVCKDGVATFTCLCRPGYTGHHCE 602
Cdd:cd00054      1 DIDECAsGNPCQNgGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
258-294 5.59e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.24  E-value: 5.59e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2178034425  258 NVDDC-PGNNCKNGGACVDGVNTYNCRCPPEWTGQYCT 294
Cdd:cd00054      1 DIDECaSGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
604-640 6.05e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.24  E-value: 6.05e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2178034425  604 NINECHSQ-PCRHGGTCQDRDNAYLCSCLKGTTGPNCE 640
Cdd:cd00054      1 DIDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
1268-1306 1.19e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.47  E-value: 1.19e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 2178034425 1268 DVNECLS-NPCDARGTqnCVQRVNDFYCECRAGHTGRRCE 1306
Cdd:cd00054      1 DIDECASgNPCQNGGT--CVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
143-176 1.30e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.08  E-value: 1.30e-04
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 2178034425  143 DPCAS-NPCANGGQCLPFEASYICGCPHGFHGPTC 176
Cdd:cd00054      3 DECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
718-751 5.47e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.54  E-value: 5.47e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 2178034425  718 VNECSS-DPCIHGA-CRDSLNGYKCDCDPGWSGANC 751
Cdd:cd00054      2 IDECASgNPCQNGGtCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
336-371 6.46e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.16  E-value: 6.46e-04
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 2178034425  336 NIDDCASAA-CFHGATCHDRVASFYCECPHGRTGLLC 371
Cdd:cd00054      1 DIDECASGNpCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
491-527 1.08e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.77  E-value: 1.08e-03
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2178034425  491 NTDECAS-SPCLQNGRCLDKINEFLCECSTGFTGHLCQ 527
Cdd:cd00054      1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
PRK12323 super family cl46901
DNA polymerase III subunit gamma/tau;
2449-2532 3.00e-03

DNA polymerase III subunit gamma/tau;


The actual alignment was detected with superfamily member PRK14950:

Pssm-ID: 481241 [Multi-domain]  Cd Length: 585  Bit Score: 42.87  E-value: 3.00e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178034425 2449 PSQADVQPLGPSSLAVHTILPQDSQALPTALPATLAPPMTTAQFLTPPsqhsyssSPADNTPSHQLQVPEHPFLTPSPES 2528
Cdd:PRK14950   378 PVRPTPAPSTRPKAAAAANIPPKEPVRETATPPPVPPRPVAPPVPHTP-------ESAPKLTRAAIPVDEKPKYTPPAPP 450

                   ....
gi 2178034425 2529 PDQW 2532
Cdd:PRK14950   451 KEEE 454
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
1316-1347 3.65e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.23  E-value: 3.65e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 2178034425 1316 PCQNGGTCavaSNTARGFICKCPAGFEGATCE 1347
Cdd:cd00054     10 PCQNGGTC---VNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
224-256 4.67e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.85  E-value: 4.67e-03
                           10        20        30
                   ....*....|....*....|....*....|...
gi 2178034425  224 SPSPCQNGGTCRPTGDTtHECACLPGFTGQNCE 256
Cdd:cd00054      7 SGNPCQNGGTCVNTVGS-YRCSCPPGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
1064-1094 7.34e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


:

Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.21  E-value: 7.34e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 2178034425 1064 CDSSPCKNGGRCWQTNTRYRCECHSGWTGLY 1094
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
 
Name Accession Description Interval E-value
JMTM_Notch1 cd21702
juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein ...
1720-1799 4.09e-49

juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein 1 (Notch1) and similar proteins; Neurogenic locus notch homolog protein 1 (Notch1), also called translocation-associated notch protein TAN-1, functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. It affects the implementation of differentiation, proliferation and apoptotic programs. It is also involved in angiogenesis, and also negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. This model corresponds to the juxtamembrane and transmembrane (JMTM) domain of Notch1, which comprises an extended coil, a transmembrane helix (TM), and a beta-strand.


Pssm-ID: 411985  Cd Length: 80  Bit Score: 169.20  E-value: 4.09e-49
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178034425 1720 AVQSETVEPPPPPQLHFMYVAVAAFVLLFFVGCGVLLSRKRRRQHGQLWFPEGFKVSEASKKKRREPLGEDSVGLKPLKN 1799
Cdd:cd21702      1 AVKSETVEPPPPSQLYPMYVVLAALVLLAFVGVGVLVSRKRRREHGQLWFPEGFKVSEPSKKKRREPVGEDSVGLKPLKN 80
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1904-2118 4.81e-37

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 142.79  E-value: 4.81e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178034425 1904 EDAPAVISDFIYQGASLHNQTDRTGETALHLAARYSRSDAAKRLLEASADANIQDNMGRTPLHAAVSADAQGVFQILIRN 1983
Cdd:COG0666     63 LAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEA 142
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178034425 1984 RAtDLDARMHDGTTPLILAARLAVEGMLEDLINSHADVNAVDDLGKSALHWAAAVNNVEAAVVLLKNGANKDMQNNKEET 2063
Cdd:COG0666    143 GA-DVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKT 221
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2178034425 2064 PLFLAAREGSYETAKVLLDHFANRDITDHMDRLPRDIAQERMHHDIVRLLDEYSL 2118
Cdd:COG0666    222 ALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALL 276
NOD pfam06816
NOTCH protein; NOTCH signalling plays a fundamental role during a great number of ...
1567-1622 4.34e-27

NOTCH protein; NOTCH signalling plays a fundamental role during a great number of developmental processes in multicellular animals. NOD and NODP represent a region present in many NOTCH proteins and NOTCH homologs in multiple species such as NOTCH2 and NOTCH3, LIN12, SC1 and TAN1. Role of NOD domain remains to be elucidated.


Pssm-ID: 462014  Cd Length: 56  Bit Score: 105.67  E-value: 4.34e-27
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2178034425 1567 PERLAAGALVLVVLTPPAQLRNNSLHFLRELSRLLHTNVVFKRDAHGQPMIFPYYG 1622
Cdd:pfam06816    1 PEKLAEGVLVIVVLMDPEELLNNSVQFLRELSTVLRTNVRFKKDENGNPMIYPWYG 56
NODP pfam07684
NOTCH protein; NOTCH signalling plays a fundamental role during a great number of ...
1671-1729 3.31e-24

NOTCH protein; NOTCH signalling plays a fundamental role during a great number of developmental processes in multicellular animals. NOD and NODP represent a region present in many NOTCH proteins and NOTCH homologs in multiple species such as NOTCH2 and NOTCH3, LIN12, SC1 and TAN1. The role of the NOD and NODP domains remains to be elucidated.


Pssm-ID: 462229  Cd Length: 59  Bit Score: 97.34  E-value: 3.31e-24
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 2178034425 1671 IRGSIVYLEIDNRQCVQSSSQCFQSATDVAAFLGALASLGSLNIPYKIEAVQSETVEPP 1729
Cdd:pfam07684    1 VIGSVVYLEIDNRKCSQSSDECFSTAQSAADFLAALAAKGGLDLPYPIKEVRSEPPPPP 59
Ank_2 pfam12796
Ankyrin repeats (3 copies);
1932-2025 9.02e-16

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 74.77  E-value: 9.02e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178034425 1932 LHLAARYSRSDAAKRLLEASADANIQDNMGRTPLHAAVSADAQGVFQILIRNRATDLDarmHDGTTPLILAARLAVEGML 2011
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNLK---DNGRTALHYAARSGHLEIV 77
                           90
                   ....*....|....
gi 2178034425 2012 EDLINSHADVNAVD 2025
Cdd:pfam12796   78 KLLLEKGADINVKD 91
PHA02878 PHA02878
ankyrin repeat protein; Provisional
1917-2089 2.81e-11

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 68.75  E-value: 2.81e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178034425 1917 GASLHNQTDRTGETALHLAARYSRSDAAKRLLEASADANIQDNMGRTPLHAAVSADAQGVFQILIRNRATdLDARMHDGT 1996
Cdd:PHA02878   157 GADINMKDRHKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGAS-TDARDKCGN 235
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178034425 1997 TPL-ILAARLAVEGMLEDLINSHADVNAVDD-LGKSALHwaAAVNNVEAAVVLLKNGANKDMQNNKEETPLFLAAREGS- 2073
Cdd:PHA02878   236 TPLhISVGYCKDYDILKLLLEHGVDVNAKSYiLGLTALH--SSIKSERKLKLLLEYGADINSLNSYKLTPLSSAVKQYLc 313
                          170       180
                   ....*....|....*....|.
gi 2178034425 2074 YETAKVLLDH-----FANRDI 2089
Cdd:PHA02878   314 INIGRILISNicllkRIKPDI 334
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
1928-2072 3.01e-09

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 62.34  E-value: 3.01e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178034425 1928 GETALHLAARYSRSDAAKRLLEASADAnIQDNM------GRTPLHAAVSADAQGVFQILIRNRATDLDAR---------- 1991
Cdd:cd22192     51 GETALHVAALYDNLEAAVVLMEAAPEL-VNEPMtsdlyqGETALHIAVVNQNLNLVRELIARGADVVSPRatgtffrpgp 129
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178034425 1992 ---MHDGTTPLILAARLAVEGMLEDLINSHADVNAVDDLGKSALHWAAAVNNVEAAVV----LLKNGANKD------MQN 2058
Cdd:cd22192    130 knlIYYGEHPLSFAACVGNEEIVRLLIEHGADIRAQDSLGNTVLHILVLQPNKTFACQmydlILSYDKEDDlqpldlVPN 209
                          170
                   ....*....|....
gi 2178034425 2059 NKEETPLFLAAREG 2072
Cdd:cd22192    210 NQGLTPFKLAAKEG 223
Notch pfam00066
LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch ...
1488-1523 1.06e-08

LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch related proteins. The structure of the domain has been determined by NMR and was shown to contain three disulphide bonds and coordinate a calcium ion. Three repeats are also found in the PAPP-A peptidase.


Pssm-ID: 459658  Cd Length: 35  Bit Score: 52.53  E-value: 1.06e-08
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 2178034425 1488 WQNCSQSlQCWKYFSNGRCDSQCNSVGCLFDGFDCQ 1523
Cdd:pfam00066    1 WPNCPYP-YCWDKFGNGVCDEECNNAECLWDGGDCS 35
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
679-714 1.86e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 52.25  E-value: 1.86e-08
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 2178034425  679 NIDECA-GNPCHHGGTCEDGVNSFTCRCPEGYHGPTC 714
Cdd:cd00054      1 DIDECAsGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
870-906 2.19e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 51.87  E-value: 2.19e-08
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2178034425  870 DINECV-KSPCRNGASCQNTNGGYRCRCRAGYTGHNCE 906
Cdd:cd00054      1 DIDECAsGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
NL smart00004
Domain found in Notch and Lin-12; The Notch protein is essential for the proper ...
1522-1562 2.64e-08

Domain found in Notch and Lin-12; The Notch protein is essential for the proper differentiation of the Drosophila ectoderm. This protein contains 3 NL domains.


Pssm-ID: 197463  Cd Length: 38  Bit Score: 51.56  E-value: 2.64e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 2178034425  1522 CQRAEGQCNplyDQYCKDHFGDGHCDQGCNSAECEWDGLDC 1562
Cdd:smart00004    1 PQDPWSRCE---DAQCWDKFGDGVCDEECNNAECLWDGGDC 38
Notch pfam00066
LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch ...
1526-1562 2.68e-08

LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch related proteins. The structure of the domain has been determined by NMR and was shown to contain three disulphide bonds and coordinate a calcium ion. Three repeats are also found in the PAPP-A peptidase.


Pssm-ID: 459658  Cd Length: 35  Bit Score: 51.76  E-value: 2.68e-08
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 2178034425 1526 EGQCNPlydQYCKDHFGDGHCDQGCNSAECEWDGLDC 1562
Cdd:pfam00066    1 WPNCPY---PYCWDKFGNGVCDEECNNAECLWDGGDC 34
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
413-451 3.48e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 51.48  E-value: 3.48e-08
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 2178034425  413 DVDECSLGaNPCEHAGKCINTLGSFECQCLQGYTGPRCE 451
Cdd:cd00054      1 DIDECASG-NPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
529-565 9.17e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 50.33  E-value: 9.17e-08
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2178034425  529 DVDECAST-PCKNGAKCLDGPNTYTCVCTEGYTGPHCE 565
Cdd:cd00054      1 DIDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
1022-1058 9.91e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 49.94  E-value: 9.91e-08
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2178034425 1022 DVNECDSR-PCLHGGTCQDSYGTYKCTCPQGYTGLNCQ 1058
Cdd:cd00054      1 DIDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
870-906 1.10e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 49.94  E-value: 1.10e-07
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 2178034425   870 DINECV-KSPCRNGASCQNTNGGYRCRCRAGYT-GHNCE 906
Cdd:smart00179    1 DIDECAsGNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
946-982 1.22e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 49.94  E-value: 1.22e-07
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2178034425  946 DINECAS-NPCRHGANCTDCVDSYTCTCPAGFSGIHCE 982
Cdd:cd00054      1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
1147-1181 2.11e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 49.17  E-value: 2.11e-07
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 2178034425 1147 VDEC-SPSPCQNGATCTDYPGGYSCECVAGYHGVNC 1181
Cdd:cd00054      2 IDECaSGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA smart00179
Calcium-binding EGF-like domain;
679-714 2.36e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 49.17  E-value: 2.36e-07
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 2178034425   679 NIDECA-GNPCHHGGTCEDGVNSFTCRCPEGYH-GPTC 714
Cdd:smart00179    1 DIDECAsGNPCQNGGTCVNTVGSYRCECPPGYTdGRNC 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
413-451 2.55e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 48.78  E-value: 2.55e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 2178034425   413 DVDECSLGaNPCEHAGKCINTLGSFECQCLQGYT-GPRCE 451
Cdd:smart00179    1 DIDECASG-NPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
NL smart00004
Domain found in Notch and Lin-12; The Notch protein is essential for the proper ...
1443-1480 2.77e-07

Domain found in Notch and Lin-12; The Notch protein is essential for the proper differentiation of the Drosophila ectoderm. This protein contains 3 NL domains.


Pssm-ID: 197463  Cd Length: 38  Bit Score: 48.86  E-value: 2.77e-07
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 2178034425  1443 PPQIEEACELPECREEAGNKVCSLACNNHACGWDGGDC 1480
Cdd:smart00004    1 PQDPWSRCEDAQCWDKFGDGVCDEECNNAECLWDGGDC 38
NL smart00004
Domain found in Notch and Lin-12; The Notch protein is essential for the proper ...
1486-1522 3.82e-07

Domain found in Notch and Lin-12; The Notch protein is essential for the proper differentiation of the Drosophila ectoderm. This protein contains 3 NL domains.


Pssm-ID: 197463  Cd Length: 38  Bit Score: 48.48  E-value: 3.82e-07
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 2178034425  1486 DPWQNCsQSLQCWKYFSNGRCDSQCNSVGCLFDGFDC 1522
Cdd:smart00004    3 DPWSRC-EDAQCWDKFGDGVCDEECNNAECLWDGGDC 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
179-217 4.14e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 48.40  E-value: 4.14e-07
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 2178034425  179 DVNECSQNPrLCQNGGTCHNEVGSYRCTCRTTHTGPHCE 217
Cdd:cd00054      1 DIDECASGN-PCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
Notch pfam00066
LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch ...
1447-1481 4.72e-07

LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch related proteins. The structure of the domain has been determined by NMR and was shown to contain three disulphide bonds and coordinate a calcium ion. Three repeats are also found in the PAPP-A peptidase.


Pssm-ID: 459658  Cd Length: 35  Bit Score: 47.91  E-value: 4.72e-07
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 2178034425 1447 EEACELPECREEAGNKVCSLACNNHACGWDGGDCS 1481
Cdd:pfam00066    1 WPNCPYPYCWDKFGNGVCDEECNNAECLWDGGDCS 35
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
296-333 4.90e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 48.02  E-value: 4.90e-07
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2178034425  296 DVDECQlMPNACQNGGTCHNSHGGYNCVCVNGWTGEDC 333
Cdd:cd00054      1 DIDECA-SGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA smart00179
Calcium-binding EGF-like domain;
946-982 7.07e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 47.63  E-value: 7.07e-07
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 2178034425   946 DINECAS-NPCRHGANCTDCVDSYTCTCPAGFS-GIHCE 982
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
453-489 7.24e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 47.63  E-value: 7.24e-07
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2178034425  453 DVNEC-ISNPCQNEATCLDQIGEFQCICMPGYEGVHCE 489
Cdd:cd00054      1 DIDECaSGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
792-828 1.59e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.48  E-value: 1.59e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2178034425  792 NINECAS-NPCLNQGSCIDDVAGYKCNCPLPYTGATCE 828
Cdd:cd00054      1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
1185-1220 2.11e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.48  E-value: 2.11e-06
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 2178034425 1185 INECVSQ-PCQNGGTCIDLTNTYKCSCPRGTQGVHCE 1220
Cdd:cd00054      2 IDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
1147-1181 2.93e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 46.09  E-value: 2.93e-06
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 2178034425  1147 VDEC-SPSPCQNGATCTDYPGGYSCECVAGYH-GVNC 1181
Cdd:smart00179    2 IDECaSGNPCQNGGTCVNTVGSYRCECPPGYTdGRNC 38
EGF_CA pfam07645
Calcium-binding EGF domain;
413-444 3.18e-06

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 45.69  E-value: 3.18e-06
                           10        20        30
                   ....*....|....*....|....*....|..
gi 2178034425  413 DVDECSLGANPCEHAGKCINTLGSFECQCLQG 444
Cdd:pfam07645    1 DVDECATGTHNCPANTVCVNTIGSFECRCPDG 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
1022-1058 3.30e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 45.70  E-value: 3.30e-06
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 2178034425  1022 DVNECDSR-PCLHGGTCQDSYGTYKCTCPQGYT-GLNCQ 1058
Cdd:smart00179    1 DIDECASGnPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
1230-1266 3.84e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 45.71  E-value: 3.84e-06
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 2178034425 1230 IDPVSRGPKCFNNGTCVDQVGGYSCTCPPGFVGERCE 1266
Cdd:cd00054      2 IDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
529-565 4.30e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 45.32  E-value: 4.30e-06
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 2178034425   529 DVDECAST-PCKNGAKCLDGPNTYTCVCTEGYT-GPHCE 565
Cdd:smart00179    1 DIDECASGnPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
179-217 6.42e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.93  E-value: 6.42e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 2178034425   179 DVNECSQNPrLCQNGGTCHNEVGSYRCTCRT-THTGPHCE 217
Cdd:smart00179    1 DIDECASGN-PCQNGGTCVNTVGSYRCECPPgYTDGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
453-489 7.74e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.55  E-value: 7.74e-06
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 2178034425   453 DVNECIS-NPCQNEATCLDQIGEFQCICMPGYE-GVHCE 489
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
908-944 8.83e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.55  E-value: 8.83e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2178034425  908 DVDDCR-PNPCHNGGSCTDGVNTAFCDCLPGFRGPFCE 944
Cdd:cd00054      1 DIDECAsGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
989-1020 1.20e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.16  E-value: 1.20e-05
                           10        20        30
                   ....*....|....*....|....*....|..
gi 2178034425  989 TESSCFNGGTCVDGINSFTCLCPPGFTGSYCQ 1020
Cdd:cd00054      7 SGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
296-333 1.22e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.16  E-value: 1.22e-05
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 2178034425   296 DVDECQlMPNACQNGGTCHNSHGGYNCVCVNGWT-GEDC 333
Cdd:smart00179    1 DIDECA-SGNPCQNGGTCVNTVGSYRCECPPGYTdGRNC 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
1184-1220 1.91e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.77  E-value: 1.91e-05
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 2178034425  1184 EINECVS-QPCQNGGTCIDLTNTYKCSCPRG-TQGVHCE 1220
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGyTDGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
756-790 3.04e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.01  E-value: 3.04e-05
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 2178034425  756 DECES-NPCANGGACRDMTSGYVCTCREGFSGPNCQ 790
Cdd:cd00054      3 DECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
567-602 3.29e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.01  E-value: 3.29e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2178034425  567 DIDECD-PDPCHY-GVCKDGVATFTCLCRPGYTGHHCE 602
Cdd:cd00054      1 DIDECAsGNPCQNgGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
683-713 3.44e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 42.76  E-value: 3.44e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 2178034425  683 CAGNPCHHGGTCEDGVNSFTCRCPEGYHGPT 713
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
533-563 4.99e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 42.37  E-value: 4.99e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 2178034425  533 CASTPCKNGAKCLDGPNTYTCVCTEGYTGPH 563
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
258-294 5.59e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.24  E-value: 5.59e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2178034425  258 NVDDC-PGNNCKNGGACVDGVNTYNCRCPPEWTGQYCT 294
Cdd:cd00054      1 DIDECaSGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
604-640 6.05e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.24  E-value: 6.05e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2178034425  604 NINECHSQ-PCRHGGTCQDRDNAYLCSCLKGTTGPNCE 640
Cdd:cd00054      1 DIDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
1026-1056 6.90e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 41.98  E-value: 6.90e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 2178034425 1026 CDSRPCLHGGTCQDSYGTYKCTCPQGYTGLN 1056
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
792-828 9.94e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.46  E-value: 9.94e-05
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 2178034425   792 NINECAS-NPCLNQGSCIDDVAGYKCNCPLPYT-GATCE 828
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
1268-1306 1.19e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.47  E-value: 1.19e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 2178034425 1268 DVNECLS-NPCDARGTqnCVQRVNDFYCECRAGHTGRRCE 1306
Cdd:cd00054      1 DIDECASgNPCQNGGT--CVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
143-176 1.30e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.08  E-value: 1.30e-04
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 2178034425  143 DPCAS-NPCANGGQCLPFEASYICGCPHGFHGPTC 176
Cdd:cd00054      3 DECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA pfam07645
Calcium-binding EGF domain;
179-208 2.07e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 40.68  E-value: 2.07e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 2178034425  179 DVNECSQNPRLCQNGGTCHNEVGSYRCTCR 208
Cdd:pfam07645    1 DVDECATGTHNCPANTVCVNTIGSFECRCP 30
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
1150-1180 2.78e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 40.06  E-value: 2.78e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 2178034425 1150 CSPSPCQNGATCTDYPGGYSCECVAGYHGVN 1180
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA pfam07645
Calcium-binding EGF domain;
296-327 2.78e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 40.30  E-value: 2.78e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 2178034425  296 DVDECQLMPNACQNGGTCHNSHGGYNCVCVNG 327
Cdd:pfam07645    1 DVDECATGTHNCPANTVCVNTIGSFECRCPDG 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
604-640 3.50e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.92  E-value: 3.50e-04
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 2178034425   604 NINECHS-QPCRHGGTCQDRDNAYLCSCLKG-TTGPNCE 640
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGyTDGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
908-944 4.26e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.92  E-value: 4.26e-04
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 2178034425   908 DVDDC-RPNPCHNGGSCTDGVNTAFCDCLPGFR-GPFCE 944
Cdd:smart00179    1 DIDECaSGNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
1222-1266 4.43e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.92  E-value: 4.43e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 2178034425  1222 NVDDCSppidpvSRGPkCFNNGTCVDQVGGYSCTCPPGFV-GERCE 1266
Cdd:smart00179    1 DIDECA------SGNP-CQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
993-1020 4.93e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.54  E-value: 4.93e-04
                            10        20
                    ....*....|....*....|....*....
gi 2178034425   993 CFNGGTCVDGINSFTCLCPPGFT-GSYCQ 1020
Cdd:smart00179   11 CQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
718-751 5.47e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.54  E-value: 5.47e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 2178034425  718 VNECSS-DPCIHGA-CRDSLNGYKCDCDPGWSGANC 751
Cdd:cd00054      2 IDECASgNPCQNGGtCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
336-371 6.46e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.16  E-value: 6.46e-04
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 2178034425  336 NIDDCASAA-CFHGATCHDRVASFYCECPHGRTGLLC 371
Cdd:cd00054      1 DIDECASGNpCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA smart00179
Calcium-binding EGF-like domain;
567-602 9.44e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.77  E-value: 9.44e-04
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 2178034425   567 DIDEC-DPDPCHYG-VCKDGVATFTCLCRPGYT-GHHCE 602
Cdd:smart00179    1 DIDECaSGNPCQNGgTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA pfam07645
Calcium-binding EGF domain;
870-899 9.60e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 38.76  E-value: 9.60e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 2178034425  870 DINECV--KSPCRNGASCQNTNGGYRCRCRAG 899
Cdd:pfam07645    1 DVDECAtgTHNCPANTVCVNTIGSFECRCPDG 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
756-790 1.01e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.77  E-value: 1.01e-03
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 2178034425   756 DECES-NPCANGGACRDMTSGYVCTCREGFS-GPNCQ 790
Cdd:smart00179    3 DECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
491-527 1.08e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.77  E-value: 1.08e-03
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2178034425  491 NTDECAS-SPCLQNGRCLDKINEFLCECSTGFTGHLCQ 527
Cdd:cd00054      1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
796-826 1.34e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 38.13  E-value: 1.34e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 2178034425  796 CASNPCLNQGSCIDDVAGYKCNCPLPYTGAT 826
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
988-1018 1.68e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 38.13  E-value: 1.68e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 2178034425  988 CTESSCFNGGTCVDGINSFTCLCPPGFTGSY 1018
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
262-292 1.82e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 37.75  E-value: 1.82e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 2178034425  262 CPGNNCKNGGACVDGVNTYNCRCPPEWTGQY 292
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
145-175 2.17e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 37.75  E-value: 2.17e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 2178034425  145 CASNPCANGGQCLPFEASYICGCPHGFHGPT 175
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
336-365 2.43e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.61  E-value: 2.43e-03
                            10        20        30
                    ....*....|....*....|....*....|.
gi 2178034425   336 NIDDCASAA-CFHGATCHDRVASFYCECPHG 365
Cdd:smart00179    1 DIDECASGNpCQNGGTCVNTVGSYRCECPPG 31
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
912-942 2.97e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 37.36  E-value: 2.97e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 2178034425  912 CRPNPCHNGGSCTDGVNTAFCDCLPGFRGPF 942
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
PRK14950 PRK14950
DNA polymerase III subunits gamma and tau; Provisional
2449-2532 3.00e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237864 [Multi-domain]  Cd Length: 585  Bit Score: 42.87  E-value: 3.00e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178034425 2449 PSQADVQPLGPSSLAVHTILPQDSQALPTALPATLAPPMTTAQFLTPPsqhsyssSPADNTPSHQLQVPEHPFLTPSPES 2528
Cdd:PRK14950   378 PVRPTPAPSTRPKAAAAANIPPKEPVRETATPPPVPPRPVAPPVPHTP-------ESAPKLTRAAIPVDEKPKYTPPAPP 450

                   ....
gi 2178034425 2529 PDQW 2532
Cdd:PRK14950   451 KEEE 454
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
1316-1347 3.65e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.23  E-value: 3.65e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 2178034425 1316 PCQNGGTCavaSNTARGFICKCPAGFEGATCE 1347
Cdd:cd00054     10 PCQNGGTC---VNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
258-294 4.22e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.84  E-value: 4.22e-03
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 2178034425   258 NVDDC-PGNNCKNGGACVDGVNTYNCRCPPEWT-GQYCT 294
Cdd:smart00179    1 DIDECaSGNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
224-256 4.67e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.85  E-value: 4.67e-03
                           10        20        30
                   ....*....|....*....|....*....|...
gi 2178034425  224 SPSPCQNGGTCRPTGDTtHECACLPGFTGQNCE 256
Cdd:cd00054      7 SGNPCQNGGTCVNTVGS-YRCSCPPGYTGRNCE 38
hEGF pfam12661
Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six ...
1239-1260 4.92e-03

Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six conserved residues disulfide-bonded into the characteriztic 'ababcc' pattern. They are involved in growth and proliferation of cells, in proteins of the Notch/Delta pathway, neurogulin and selectins. hEGFs are also found in mosaic proteins with four-disulfide laminin EGFs such as aggrecan and perlecan. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal Cys residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In hEGFs the C-terminal thiol resides in the beta-turn, resulting in shorter loop-lengths between the Cys residues of disulfide 'c', typically C[8-9]XC. These shorter loop-lengths are also typical of the four-disulfide EGF domains, laminin ad integrin. Tandem hEGF domains have six linking residues between terminal cysteines of adjacent domains. hEGF domains may or may not bind calcium in the linker region. hEGF domains with the consensus motif CXD4X[F,Y]XCXC are hydroxylated exclusively in the Asp residue.


Pssm-ID: 463660  Cd Length: 22  Bit Score: 36.54  E-value: 4.92e-03
                           10        20
                   ....*....|....*....|..
gi 2178034425 1239 CFNNGTCVDQVGGYSCTCPPGF 1260
Cdd:pfam12661    1 CQNGGTCVDGVNGYKCQCPPGY 22
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
1064-1094 7.34e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.21  E-value: 7.34e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 2178034425 1064 CDSSPCKNGGRCWQTNTRYRCECHSGWTGLY 1094
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
717-752 7.92e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.07  E-value: 7.92e-03
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 2178034425   717 EVNECSS-DPCIHGA-CRDSLNGYKCDCDPGWS-GANCD 752
Cdd:smart00179    1 DIDECASgNPCQNGGtCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
1268-1306 8.49e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.07  E-value: 8.49e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 2178034425  1268 DVNECLS-NPCDARGTqnCVQRVNDFYCECRAGHT-GRRCE 1306
Cdd:smart00179    1 DIDECASgNPCQNGGT--CVNTVGSYRCECPPGYTdGRNCE 39
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
1188-1218 8.68e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 35.82  E-value: 8.68e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 2178034425 1188 CVSQPCQNGGTCIDLTNTYKCSCPRGTQGVH 1218
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
143-176 9.18e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.07  E-value: 9.18e-03
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 2178034425   143 DPCAS-NPCANGGQCLPFEASYICGCPHGFH-GPTC 176
Cdd:smart00179    3 DECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNC 38
 
Name Accession Description Interval E-value
JMTM_Notch1 cd21702
juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein ...
1720-1799 4.09e-49

juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein 1 (Notch1) and similar proteins; Neurogenic locus notch homolog protein 1 (Notch1), also called translocation-associated notch protein TAN-1, functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. It affects the implementation of differentiation, proliferation and apoptotic programs. It is also involved in angiogenesis, and also negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. This model corresponds to the juxtamembrane and transmembrane (JMTM) domain of Notch1, which comprises an extended coil, a transmembrane helix (TM), and a beta-strand.


Pssm-ID: 411985  Cd Length: 80  Bit Score: 169.20  E-value: 4.09e-49
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178034425 1720 AVQSETVEPPPPPQLHFMYVAVAAFVLLFFVGCGVLLSRKRRRQHGQLWFPEGFKVSEASKKKRREPLGEDSVGLKPLKN 1799
Cdd:cd21702      1 AVKSETVEPPPPSQLYPMYVVLAALVLLAFVGVGVLVSRKRRREHGQLWFPEGFKVSEPSKKKRREPVGEDSVGLKPLKN 80
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1904-2118 4.81e-37

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 142.79  E-value: 4.81e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178034425 1904 EDAPAVISDFIYQGASLHNQTDRTGETALHLAARYSRSDAAKRLLEASADANIQDNMGRTPLHAAVSADAQGVFQILIRN 1983
Cdd:COG0666     63 LAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEA 142
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178034425 1984 RAtDLDARMHDGTTPLILAARLAVEGMLEDLINSHADVNAVDDLGKSALHWAAAVNNVEAAVVLLKNGANKDMQNNKEET 2063
Cdd:COG0666    143 GA-DVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKT 221
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2178034425 2064 PLFLAAREGSYETAKVLLDHFANRDITDHMDRLPRDIAQERMHHDIVRLLDEYSL 2118
Cdd:COG0666    222 ALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALL 276
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1917-2116 6.35e-37

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 142.40  E-value: 6.35e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178034425 1917 GASLHNQTDRTGETALHLAARYSRSDAAKRLLEASADANIQDNMGRTPLHAAVSADAQGVFQILIRNRAtDLDARMHDGT 1996
Cdd:COG0666     43 ALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGA-DVNARDKDGE 121
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178034425 1997 TPLILAARLAVEGMLEDLINSHADVNAVDDLGKSALHWAAAVNNVEAAVVLLKNGANKDMQNNKEETPLFLAAREGSYET 2076
Cdd:COG0666    122 TPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEI 201
                          170       180       190       200
                   ....*....|....*....|....*....|....*....|
gi 2178034425 2077 AKVLLDHFANRDITDHMDRLPRDIAQERMHHDIVRLLDEY 2116
Cdd:COG0666    202 VKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEA 241
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1873-2092 1.15e-35

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 138.55  E-value: 1.15e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178034425 1873 DVNVRGPDGFTPLMIASCSGggletgnseeeedAPAVISDFIYQGASLhNQTDRTGETALHLAARYSRSDAAKRLLEASA 1952
Cdd:COG0666     79 DINAKDDGGNTLLHAAARNG-------------DLEIVKLLLEAGADV-NARDKDGETPLHLAAYNGNLEIVKLLLEAGA 144
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178034425 1953 DANIQDNMGRTPLHAAVSADAQGVFQILIRNRAtDLDARMHDGTTPLILAARLAVEGMLEDLINSHADVNAVDDLGKSAL 2032
Cdd:COG0666    145 DVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGA-DVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTAL 223
                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178034425 2033 HWAAAVNNVEAAVVLLKNGANKDMQNNKEETPLFLAAREGSYETAKVLLDHFANRDITDH 2092
Cdd:COG0666    224 DLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALL 283
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1873-2065 1.03e-30

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 124.30  E-value: 1.03e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178034425 1873 DVNVRGPDGFTPLMIASCSGggletgnseeeedAPAVISDFIYQGASLhNQTDRTGETALHLAARYSRSDAAKRLLEASA 1952
Cdd:COG0666    112 DVNARDKDGETPLHLAAYNG-------------NLEIVKLLLEAGADV-NAQDNDGNTPLHLAAANGNLEIVKLLLEAGA 177
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178034425 1953 DANIQDNMGRTPLHAAVSADAQGVFQILIRNRAtDLDARMHDGTTPLILAARLAVEGMLEDLINSHADVNAVDDLGKSAL 2032
Cdd:COG0666    178 DVNARDNDGETPLHLAAENGHLEIVKLLLEAGA-DVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTAL 256
                          170       180       190
                   ....*....|....*....|....*....|...
gi 2178034425 2033 HWAAAVNNVEAAVVLLKNGANKDMQNNKEETPL 2065
Cdd:COG0666    257 LLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
JMTM_Notch cd21701
juxtamembrane and transmembrane (JMTM) domain found in Notch protein family; Neurogenic locus ...
1715-1797 2.65e-28

juxtamembrane and transmembrane (JMTM) domain found in Notch protein family; Neurogenic locus notch homolog (Notch) proteins are a family of type-1 transmembrane proteins that form a core component of the Notch signaling pathway. They operate in a variety of different tissues and play a role in a variety of developmental processes by controlling cell fate decisions. The model corresponds to the juxtamembrane and transmembrane (JMTM) domain of Notch proteins, which comprises an extended coil, a transmembrane helix (TM), and a beta-strand.


Pssm-ID: 411984  Cd Length: 85  Bit Score: 110.16  E-value: 2.65e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178034425 1715 PYKIEAVQSET--VEPPPPPQLHFMYVAVAAFVLLFFVGCGVLLSRKRRRqHGQLWFPEGFKVSEASK-KKRREPLGEDS 1791
Cdd:cd21701      1 PYPIYSVRSEPgpATKTTPPAQLSPLVVAAVCVLLVLVVLGVLVARKRRR-HGTLWFPEGFPRTRASRrSRRRDPVGQDS 79

                   ....*.
gi 2178034425 1792 VGLKPL 1797
Cdd:cd21701     80 VGLKNL 85
NOD pfam06816
NOTCH protein; NOTCH signalling plays a fundamental role during a great number of ...
1567-1622 4.34e-27

NOTCH protein; NOTCH signalling plays a fundamental role during a great number of developmental processes in multicellular animals. NOD and NODP represent a region present in many NOTCH proteins and NOTCH homologs in multiple species such as NOTCH2 and NOTCH3, LIN12, SC1 and TAN1. Role of NOD domain remains to be elucidated.


Pssm-ID: 462014  Cd Length: 56  Bit Score: 105.67  E-value: 4.34e-27
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2178034425 1567 PERLAAGALVLVVLTPPAQLRNNSLHFLRELSRLLHTNVVFKRDAHGQPMIFPYYG 1622
Cdd:pfam06816    1 PEKLAEGVLVIVVLMDPEELLNNSVQFLRELSTVLRTNVRFKKDENGNPMIYPWYG 56
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1908-2113 6.36e-27

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 113.13  E-value: 6.36e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178034425 1908 AVISDFIYQGASLHNQTDRTGETALHLAARYSRSDAAKRLLEASADANIQDNMGRTPLHAAVSADAQGVFQILIRNRAtD 1987
Cdd:COG0666      1 LLLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGA-D 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178034425 1988 LDARMHDGTTPLILAARLAVEGMLEDLINSHADVNAVDDLGKSALHWAAAVNNVEAAVVLLKNGANKDMQNNKEETPLFL 2067
Cdd:COG0666     80 INAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHL 159
                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*.
gi 2178034425 2068 AAREGSYETAKVLLDHFANRDITDHMDRLPRDIAQERMHHDIVRLL 2113
Cdd:COG0666    160 AAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLL 205
NODP pfam07684
NOTCH protein; NOTCH signalling plays a fundamental role during a great number of ...
1671-1729 3.31e-24

NOTCH protein; NOTCH signalling plays a fundamental role during a great number of developmental processes in multicellular animals. NOD and NODP represent a region present in many NOTCH proteins and NOTCH homologs in multiple species such as NOTCH2 and NOTCH3, LIN12, SC1 and TAN1. The role of the NOD and NODP domains remains to be elucidated.


Pssm-ID: 462229  Cd Length: 59  Bit Score: 97.34  E-value: 3.31e-24
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 2178034425 1671 IRGSIVYLEIDNRQCVQSSSQCFQSATDVAAFLGALASLGSLNIPYKIEAVQSETVEPP 1729
Cdd:pfam07684    1 VIGSVVYLEIDNRKCSQSSDECFSTAQSAADFLAALAAKGGLDLPYPIKEVRSEPPPPP 59
JMTM_Notch2 cd21703
juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein ...
1714-1797 1.83e-23

juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein 2 (Notch2) and similar proteins; Neurogenic locus notch homolog protein 2 (Notch2) functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Notch2 is involved in bone remodeling and homeostasis. In collaboration with RELA/p65, it enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation. Notch2 positively regulates self-renewal of liver cancer cells. This model corresponds to the juxtamembrane and transmembrane (JMTM) domain of Notch2, which comprises an extended coil, a transmembrane helix (TM), and a beta-strand.


Pssm-ID: 411986  Cd Length: 82  Bit Score: 96.37  E-value: 1.83e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178034425 1714 IPYKIEAVQSEtvePPPPPQLHFMY-VAVAAFVLLFFVGCGVLLSrKRRRQHGQLWFPEGFKVS-EASKKKRREPLGEDS 1791
Cdd:cd21703      1 LPYPLVSVTSE---PLKETKFNLLYlLAVAVAIILLILLLGVLVA-KRKRKHGPLWFPEGFILNkENSNRKRREPVGQDA 76

                   ....*.
gi 2178034425 1792 VGLKPL 1797
Cdd:cd21703     77 VGMKNL 82
JMTM_Notch3 cd21704
juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein ...
1712-1795 4.67e-22

juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein 3 (Notch3) and similar proteins; Neurogenic locus notch homolog protein 3 (Notch3) functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. The model corresponds to the juxtamembrane and transmembrane (JMTM) domain of Notch3, which comprises an extended coil, a transmembrane helix (TM), and a beta-strand.


Pssm-ID: 411987  Cd Length: 90  Bit Score: 92.50  E-value: 4.67e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178034425 1712 LNIPYKIEAVQSETVEPPPPPQLHFMYVAVAAFVLLFFVGCGVLLSRkRRRQHGQLWFPEGFKV-SEASKKKRREPLGED 1790
Cdd:cd21704      3 LEFPYPIKEVRGEKLEPPPPPVRLLPLLGVAAVILLVILVLGVLVAR-RKREHSTLWFPEGFFLkKESSNKNRREPVGQD 81

                   ....*
gi 2178034425 1791 SVGLK 1795
Cdd:cd21704     82 ALGMK 86
JMTM_Notch4 cd21705
juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein ...
1714-1798 2.36e-18

juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein 4 (Notch4) and similar proteins; Neurogenic locus notch homolog protein 4 (Notch4) functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. It affects the implementation of differentiation, proliferation and apoptotic programs. This model corresponds to the juxtamembrane and transmembrane (JMTM) domain of Notch4, which comprises an extended coil, a transmembrane helix (TM), and a beta-strand.


Pssm-ID: 411988  Cd Length: 92  Bit Score: 82.05  E-value: 2.36e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178034425 1714 IPYKIEAVQSETVEPPPP---PQL--HFMYVAVAAFVLLFF-VGCGVLLSRKRRRQHGQLWFPEGFKVSEASK-KKRREP 1786
Cdd:cd21705      1 LPFPLLAVTVEEAEKDPQlvaAQLpwPLVCSSVAGVLALVLgALLGVQLIRRRQREHGALWLPPGFARHRDPNpHRRREP 80
                           90
                   ....*....|..
gi 2178034425 1787 LGEDSVGLKPLK 1798
Cdd:cd21705     81 VGEDAIGLKPLK 92
Ank_2 pfam12796
Ankyrin repeats (3 copies);
1932-2025 9.02e-16

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 74.77  E-value: 9.02e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178034425 1932 LHLAARYSRSDAAKRLLEASADANIQDNMGRTPLHAAVSADAQGVFQILIRNRATDLDarmHDGTTPLILAARLAVEGML 2011
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNLK---DNGRTALHYAARSGHLEIV 77
                           90
                   ....*....|....
gi 2178034425 2012 EDLINSHADVNAVD 2025
Cdd:pfam12796   78 KLLLEKGADINVKD 91
JMTM_dNotch cd21706
juxtamembrane and transmembrane (JMTM) domain found in Drosophila melanogaster neurogenic ...
1716-1784 1.14e-12

juxtamembrane and transmembrane (JMTM) domain found in Drosophila melanogaster neurogenic locus Notch protein (dNotch) and similar proteins; Drosophila melanogaster neurogenic locus Notch protein (dNotch) is an essential signaling protein which has a major role in many developmental processes. It functions as a receptor for membrane-bound ligands Delta and Serrate to regulate cell-fate determination. It regulates oogenesis, the differentiation of the ectoderm and the development of the central and peripheral nervous system, eye, wing disk, muscles and segmental appendages such as antennae and legs, through lateral inhibition or induction. It also regulates neuroblast self-renewal, identity and proliferation through the regulation of bHLH-O proteins; in larval brains, it is involved in the maintenance of type II neuroblast self-renewal and identity by suppressing erm expression together with pnt. It might also regulate dpn expression through the activation of the transcriptional regulator Su(H). This model corresponds to the juxtamembrane and transmembrane (JMTM) domain of dNotch, which comprises an extended coil, a transmembrane helix (TM), and a beta-strand.


Pssm-ID: 411989  Cd Length: 90  Bit Score: 65.74  E-value: 1.14e-12
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178034425 1716 YKIEAVQSETVEPPPPPQlHFMYVAVAAFVLLFFVGC-GVLLSRKRRRQHGQLWFPEGFKVSEASKKKRR 1784
Cdd:cd21706      5 YQVRGEDPPDPPPEPPPS-NLTYVVIGVVVVLLIGLLlGVLVTTQRKRARGITWFPEGFFTTSSSQRRRR 73
PHA02878 PHA02878
ankyrin repeat protein; Provisional
1917-2089 2.81e-11

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 68.75  E-value: 2.81e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178034425 1917 GASLHNQTDRTGETALHLAARYSRSDAAKRLLEASADANIQDNMGRTPLHAAVSADAQGVFQILIRNRATdLDARMHDGT 1996
Cdd:PHA02878   157 GADINMKDRHKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGAS-TDARDKCGN 235
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178034425 1997 TPL-ILAARLAVEGMLEDLINSHADVNAVDD-LGKSALHwaAAVNNVEAAVVLLKNGANKDMQNNKEETPLFLAAREGS- 2073
Cdd:PHA02878   236 TPLhISVGYCKDYDILKLLLEHGVDVNAKSYiLGLTALH--SSIKSERKLKLLLEYGADINSLNSYKLTPLSSAVKQYLc 313
                          170       180
                   ....*....|....*....|.
gi 2178034425 2074 YETAKVLLDH-----FANRDI 2089
Cdd:PHA02878   314 INIGRILISNicllkRIKPDI 334
PHA03095 PHA03095
ankyrin-like protein; Provisional
1873-2081 2.83e-11

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 68.51  E-value: 2.83e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178034425 1873 DVNVRGPDGFTPLMIASCsggGLETgnseeeedAPAVISDFIYQGASLhNQTDRTGETALHLAARYSRSDAA--KRLLEA 1950
Cdd:PHA03095   109 DVNAKDKVGRTPLHVYLS---GFNI--------NPKVIRLLLRKGADV-NALDLYGMTPLAVLLKSRNANVEllRLLIDA 176
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178034425 1951 SADANIQDNMGRTPLHA-AVSADA-QGVFQILIRnRATDLDARMHDGTTPLILAARLAV--EGMLEDLINSHADVNAVDD 2026
Cdd:PHA03095   177 GADVYAVDDRFRSLLHHhLQSFKPrARIVRELIR-AGCDPAATDMLGNTPLHSMATGSSckRSLVLPLLIAGISINARNR 255
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2178034425 2027 LGKSALHWAAAVNNVEAAVVLLKNGANKDMQNNKEETPLFLAAREGSYETAKVLL 2081
Cdd:PHA03095   256 YGQTPLHYAAVFNNPRACRRLIALGADINAVSSDGNTPLSLMVRNNNGRAVRAAL 310
PHA03095 PHA03095
ankyrin-like protein; Provisional
1873-2033 1.55e-10

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 66.20  E-value: 1.55e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178034425 1873 DVNVRGPDGFTPL-MIASCSGggletgnseeeEDAPAVISDFIYQGASLhNQTDRTGETALHLAARYS-RSDAAKRLLEA 1950
Cdd:PHA03095    39 DVNFRGEYGKTPLhLYLHYSS-----------EKVKDIVRLLLEAGADV-NAPERCGFTPLHLYLYNAtTLDVIKLLIKA 106
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178034425 1951 SADANIQDNMGRTPLHAAVSADA--QGVFQILIRNRAtDLDARMHDGTTPL---ILAARLAVEgMLEDLINSHADVNAVD 2025
Cdd:PHA03095   107 GADVNAKDKVGRTPLHVYLSGFNinPKVIRLLLRKGA-DVNALDLYGMTPLavlLKSRNANVE-LLRLLIDAGADVYAVD 184

                   ....*...
gi 2178034425 2026 DLGKSALH 2033
Cdd:PHA03095   185 DRFRSLLH 192
Ank_2 pfam12796
Ankyrin repeats (3 copies);
1999-2091 2.00e-10

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 59.36  E-value: 2.00e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178034425 1999 LILAARLAVEGMLEDLINSHADVNAVDDLGKSALHWAAAVNNVEAAVVLLKNgANKDMQNNKeETPLFLAAREGSYETAK 2078
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKDNG-RTALHYAARSGHLEIVK 78
                           90
                   ....*....|...
gi 2178034425 2079 VLLDHFANRDITD 2091
Cdd:pfam12796   79 LLLEKGADINVKD 91
PHA03095 PHA03095
ankyrin-like protein; Provisional
1914-2086 5.51e-10

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 64.28  E-value: 5.51e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178034425 1914 IYQGASLhNQTDRTGETALHLAARYS---RSDAAKRLLEASADANIQDNMGRTPLHAAV-SADAQGVFQILIRNRAtDLD 1989
Cdd:PHA03095    34 LAAGADV-NFRGEYGKTPLHLYLHYSsekVKDIVRLLLEAGADVNAPERCGFTPLHLYLyNATTLDVIKLLIKAGA-DVN 111
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178034425 1990 ARMHDGTTPL--ILAARLAVEGMLEDLINSHADVNAVDDLGKSALHwaaavnnveaavVLLKN-GANKDMQNnkeetpLF 2066
Cdd:PHA03095   112 AKDKVGRTPLhvYLSGFNINPKVIRLLLRKGADVNALDLYGMTPLA------------VLLKSrNANVELLR------LL 173
                          170       180
                   ....*....|....*....|....*
gi 2178034425 2067 LAAreGSYETAK-----VLLDHFAN 2086
Cdd:PHA03095   174 IDA--GADVYAVddrfrSLLHHHLQ 196
PHA02875 PHA02875
ankyrin repeat protein; Provisional
1922-2113 8.02e-10

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 63.86  E-value: 8.02e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178034425 1922 NQTDRTGETALHLAARYSRSDAAKRLLEASADANIQDNMGRTPLHAAV-SADAQGVFQILIRNRATDlDARMHDGTTPLI 2000
Cdd:PHA02875    29 NFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVeEGDVKAVEELLDLGKFAD-DVFYKDGMTPLH 107
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178034425 2001 LAARLAVEGMLEDLINSHADVNAVDDLGKSALHWAAAVNNVEAAVVLLKNGANKDMQNNKEETPLFLAAREGSYETAKVL 2080
Cdd:PHA02875   108 LATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKML 187
                          170       180       190
                   ....*....|....*....|....*....|....*...
gi 2178034425 2081 LDHFANrdiTDHMDRLPrDI-----AQERMHHDIVRLL 2113
Cdd:PHA02875   188 LDSGAN---IDYFGKNG-CVaalcyAIENNKIDIVRLF 221
PHA03095 PHA03095
ankyrin-like protein; Provisional
1945-2086 2.48e-09

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 62.35  E-value: 2.48e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178034425 1945 KRLLEASADANIQDNMGRTPLHAAV---SADAQGVFQILIRNRAtDLDARMHDGTTPLILAARLA-VEGMLEDLINSHAD 2020
Cdd:PHA03095    31 RRLLAAGADVNFRGEYGKTPLHLYLhysSEKVKDIVRLLLEAGA-DVNAPERCGFTPLHLYLYNAtTLDVIKLLIKAGAD 109
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178034425 2021 VNAVDDLGKSALHWAAAVNNVEAA--VVLLKNGANKDMQNNKEETPL--FLAAREGSYETAKVLLDHFAN 2086
Cdd:PHA03095   110 VNAKDKVGRTPLHVYLSGFNINPKviRLLLRKGADVNALDLYGMTPLavLLKSRNANVELLRLLIDAGAD 179
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
1928-2072 3.01e-09

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 62.34  E-value: 3.01e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178034425 1928 GETALHLAARYSRSDAAKRLLEASADAnIQDNM------GRTPLHAAVSADAQGVFQILIRNRATDLDAR---------- 1991
Cdd:cd22192     51 GETALHVAALYDNLEAAVVLMEAAPEL-VNEPMtsdlyqGETALHIAVVNQNLNLVRELIARGADVVSPRatgtffrpgp 129
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178034425 1992 ---MHDGTTPLILAARLAVEGMLEDLINSHADVNAVDDLGKSALHWAAAVNNVEAAVV----LLKNGANKD------MQN 2058
Cdd:cd22192    130 knlIYYGEHPLSFAACVGNEEIVRLLIEHGADIRAQDSLGNTVLHILVLQPNKTFACQmydlILSYDKEDDlqpldlVPN 209
                          170
                   ....*....|....
gi 2178034425 2059 NKEETPLFLAAREG 2072
Cdd:cd22192    210 NQGLTPFKLAAKEG 223
PHA02876 PHA02876
ankyrin repeat protein; Provisional
1922-2116 3.71e-09

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 62.39  E-value: 3.71e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178034425 1922 NQTDRTGETALHLAARYS-RSDAAKRLLEASADANIQDNMGRTPLHAAVSADAQGVFQILIRNRATDLDARMHDGTTPLI 2000
Cdd:PHA02876   301 NAKNIKGETPLYLMAKNGyDTENIRTLIMLGADVNAADRLYITPLHQASTLDRNKDIVITLLELGANVNARDYCDKTPIH 380
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178034425 2001 LAARLAVEGMLEDLINSHADVNAVDDLGKSALHWA-AAVNNVEAAVVLLKNGANKDMQNNKEETPLFLAAREG-SYETAK 2078
Cdd:PHA02876   381 YAAVRNNVVIINTLLDYGADIEALSQKIGTALHFAlCGTNPYMSVKTLIDRGANVNSKNKDLSTPLHYACKKNcKLDVIE 460
                          170       180       190
                   ....*....|....*....|....*....|....*...
gi 2178034425 2079 VLLDHFANRDITDHMDRLPRDIAQErmHHDIVRLLDEY 2116
Cdd:PHA02876   461 MLLDNGADVNAINIQNQYPLLIALE--YHGIVNILLHY 496
Ank_5 pfam13857
Ankyrin repeats (many copies);
1917-1968 9.26e-09

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 53.50  E-value: 9.26e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 2178034425 1917 GASLHNQTDRTGETALHLAARYSRSDAAKRLLEASADANIQDNMGRTPLHAA 1968
Cdd:pfam13857    5 GPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
Notch pfam00066
LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch ...
1488-1523 1.06e-08

LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch related proteins. The structure of the domain has been determined by NMR and was shown to contain three disulphide bonds and coordinate a calcium ion. Three repeats are also found in the PAPP-A peptidase.


Pssm-ID: 459658  Cd Length: 35  Bit Score: 52.53  E-value: 1.06e-08
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 2178034425 1488 WQNCSQSlQCWKYFSNGRCDSQCNSVGCLFDGFDCQ 1523
Cdd:pfam00066    1 WPNCPYP-YCWDKFGNGVCDEECNNAECLWDGGDCS 35
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
1845-2062 1.23e-08

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 60.65  E-value: 1.23e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178034425 1845 QQHLDAADLRVSAMaPTPPQGEADTDCMDVNVrgpdgftpLMIAScsgggleTGNSeeeedapAVISDFIYQGASlHNQT 1924
Cdd:PLN03192   499 QHHKELHDLNVGDL-LGDNGGEHDDPNMASNL--------LTVAS-------TGNA-------ALLEELLKAKLD-PDIG 554
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178034425 1925 DRTGETALHLAARYSRSDAAKRLLEASADANIQDNMGRTPLHAAVSADAQGVFQILIR-NRATDldarMHDGTTPLILAA 2003
Cdd:PLN03192   555 DSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHKIFRILYHfASISD----PHAAGDLLCTAA 630
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 2178034425 2004 RLAVEGMLEDLINSHADVNAVDDLGKSALHWAAAVNNVEAAVVLLKNGANKDMQNNKEE 2062
Cdd:PLN03192   631 KRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGADVDKANTDDD 689
Ank_2 pfam12796
Ankyrin repeats (3 copies);
2047-2113 1.83e-08

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 53.97  E-value: 1.83e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2178034425 2047 LLKNGANKDMQNNKEETPLFLAAREGSYETAKVLLDHfANRDITDHmDRLPRDIAQERMHHDIVRLL 2113
Cdd:pfam12796   16 LLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKDN-GRTALHYAARSGHLEIVKLL 80
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
679-714 1.86e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 52.25  E-value: 1.86e-08
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 2178034425  679 NIDECA-GNPCHHGGTCEDGVNSFTCRCPEGYHGPTC 714
Cdd:cd00054      1 DIDECAsGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
870-906 2.19e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 51.87  E-value: 2.19e-08
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2178034425  870 DINECV-KSPCRNGASCQNTNGGYRCRCRAGYTGHNCE 906
Cdd:cd00054      1 DIDECAsGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
NL smart00004
Domain found in Notch and Lin-12; The Notch protein is essential for the proper ...
1522-1562 2.64e-08

Domain found in Notch and Lin-12; The Notch protein is essential for the proper differentiation of the Drosophila ectoderm. This protein contains 3 NL domains.


Pssm-ID: 197463  Cd Length: 38  Bit Score: 51.56  E-value: 2.64e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 2178034425  1522 CQRAEGQCNplyDQYCKDHFGDGHCDQGCNSAECEWDGLDC 1562
Cdd:smart00004    1 PQDPWSRCE---DAQCWDKFGDGVCDEECNNAECLWDGGDC 38
Notch pfam00066
LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch ...
1526-1562 2.68e-08

LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch related proteins. The structure of the domain has been determined by NMR and was shown to contain three disulphide bonds and coordinate a calcium ion. Three repeats are also found in the PAPP-A peptidase.


Pssm-ID: 459658  Cd Length: 35  Bit Score: 51.76  E-value: 2.68e-08
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 2178034425 1526 EGQCNPlydQYCKDHFGDGHCDQGCNSAECEWDGLDC 1562
Cdd:pfam00066    1 WPNCPY---PYCWDKFGNGVCDEECNNAECLWDGGDC 34
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
413-451 3.48e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 51.48  E-value: 3.48e-08
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 2178034425  413 DVDECSLGaNPCEHAGKCINTLGSFECQCLQGYTGPRCE 451
Cdd:cd00054      1 DIDECASG-NPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
PHA03100 PHA03100
ankyrin repeat protein; Provisional
1932-2113 6.75e-08

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 57.75  E-value: 6.75e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178034425 1932 LHLAARYSRSDAAKRLLEASADANIQDNMGRTPLH-----AAVSADAQGVFQILIRNRAtDLDARMHDGTTPLILAARLA 2006
Cdd:PHA03100    39 LYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHylsniKYNLTDVKEIVKLLLEYGA-NVNAPDNNGITPLLYAISKK 117
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178034425 2007 VEG--MLEDLINSHADVNAVDDLGKSALHWAAAVNNVEAA------------------VVLLKNGANKDMQNNKEETPLF 2066
Cdd:PHA03100   118 SNSysIVEYLLDNGANVNIKNSDGENLLHLYLESNKIDLKilkllidkgvdinaknrvNYLLSYGVPINIKDVYGFTPLH 197
                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*..
gi 2178034425 2067 LAAREGSYETAKVLLDHFANRDITDHMDRLPRDIAQERMHHDIVRLL 2113
Cdd:PHA03100   198 YAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLL 244
Ank_2 pfam12796
Ankyrin repeats (3 copies);
1873-1958 7.09e-08

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 52.04  E-value: 7.09e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178034425 1873 DVNVRGPDGFTPLMIAsCSGGGLEtgnseeeedapavISDFIYQGASLHNQTDrtGETALHLAARYSRSDAAKRLLEASA 1952
Cdd:pfam12796   22 DANLQDKNGRTALHLA-AKNGHLE-------------IVKLLLEHADVNLKDN--GRTALHYAARSGHLEIVKLLLEKGA 85

                   ....*.
gi 2178034425 1953 DANIQD 1958
Cdd:pfam12796   86 DINVKD 91
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
529-565 9.17e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 50.33  E-value: 9.17e-08
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2178034425  529 DVDECAST-PCKNGAKCLDGPNTYTCVCTEGYTGPHCE 565
Cdd:cd00054      1 DIDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
1022-1058 9.91e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 49.94  E-value: 9.91e-08
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2178034425 1022 DVNECDSR-PCLHGGTCQDSYGTYKCTCPQGYTGLNCQ 1058
Cdd:cd00054      1 DIDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
870-906 1.10e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 49.94  E-value: 1.10e-07
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 2178034425   870 DINECV-KSPCRNGASCQNTNGGYRCRCRAGYT-GHNCE 906
Cdd:smart00179    1 DIDECAsGNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
946-982 1.22e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 49.94  E-value: 1.22e-07
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2178034425  946 DINECAS-NPCRHGANCTDCVDSYTCTCPAGFSGIHCE 982
Cdd:cd00054      1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
1147-1181 2.11e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 49.17  E-value: 2.11e-07
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 2178034425 1147 VDEC-SPSPCQNGATCTDYPGGYSCECVAGYHGVNC 1181
Cdd:cd00054      2 IDECaSGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA smart00179
Calcium-binding EGF-like domain;
679-714 2.36e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 49.17  E-value: 2.36e-07
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 2178034425   679 NIDECA-GNPCHHGGTCEDGVNSFTCRCPEGYH-GPTC 714
Cdd:smart00179    1 DIDECAsGNPCQNGGTCVNTVGSYRCECPPGYTdGRNC 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
413-451 2.55e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 48.78  E-value: 2.55e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 2178034425   413 DVDECSLGaNPCEHAGKCINTLGSFECQCLQGYT-GPRCE 451
Cdd:smart00179    1 DIDECASG-NPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
NL smart00004
Domain found in Notch and Lin-12; The Notch protein is essential for the proper ...
1443-1480 2.77e-07

Domain found in Notch and Lin-12; The Notch protein is essential for the proper differentiation of the Drosophila ectoderm. This protein contains 3 NL domains.


Pssm-ID: 197463  Cd Length: 38  Bit Score: 48.86  E-value: 2.77e-07
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 2178034425  1443 PPQIEEACELPECREEAGNKVCSLACNNHACGWDGGDC 1480
Cdd:smart00004    1 PQDPWSRCEDAQCWDKFGDGVCDEECNNAECLWDGGDC 38
PHA02876 PHA02876
ankyrin repeat protein; Provisional
1910-2114 3.72e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 55.84  E-value: 3.72e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178034425 1910 ISDFIYQGASLHNQTDRTGETALHLAARYSRSDAAKRLLEASADANIQDNMGRTPLHAAVSADAQGVFQILIRNRATdld 1989
Cdd:PHA02876   160 IAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIIDNRSN--- 236
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178034425 1990 arMHDGTTPLILAAR---LAVEGMLEDlinSHADVNAVDDLGKSALHWAAAVNN-VEAAVVLLKNGANKDMQNNKEETPL 2065
Cdd:PHA02876   237 --INKNDLSLLKAIRnedLETSLLLYD---AGFSVNSIDDCKNTPLHHASQAPSlSRLVPKLLERGADVNAKNIKGETPL 311
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|..
gi 2178034425 2066 FLAAREG-SYETAKVLLDHFANRDITDHMDRLPRDIAQ--ERMHHDIVRLLD 2114
Cdd:PHA02876   312 YLMAKNGyDTENIRTLIMLGADVNAADRLYITPLHQAStlDRNKDIVITLLE 363
NL smart00004
Domain found in Notch and Lin-12; The Notch protein is essential for the proper ...
1486-1522 3.82e-07

Domain found in Notch and Lin-12; The Notch protein is essential for the proper differentiation of the Drosophila ectoderm. This protein contains 3 NL domains.


Pssm-ID: 197463  Cd Length: 38  Bit Score: 48.48  E-value: 3.82e-07
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 2178034425  1486 DPWQNCsQSLQCWKYFSNGRCDSQCNSVGCLFDGFDC 1522
Cdd:smart00004    3 DPWSRC-EDAQCWDKFGDGVCDEECNNAECLWDGGDC 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
179-217 4.14e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 48.40  E-value: 4.14e-07
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 2178034425  179 DVNECSQNPrLCQNGGTCHNEVGSYRCTCRTTHTGPHCE 217
Cdd:cd00054      1 DIDECASGN-PCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
Notch pfam00066
LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch ...
1447-1481 4.72e-07

LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch related proteins. The structure of the domain has been determined by NMR and was shown to contain three disulphide bonds and coordinate a calcium ion. Three repeats are also found in the PAPP-A peptidase.


Pssm-ID: 459658  Cd Length: 35  Bit Score: 47.91  E-value: 4.72e-07
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 2178034425 1447 EEACELPECREEAGNKVCSLACNNHACGWDGGDCS 1481
Cdd:pfam00066    1 WPNCPYPYCWDKFGNGVCDEECNNAECLWDGGDCS 35
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
296-333 4.90e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 48.02  E-value: 4.90e-07
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2178034425  296 DVDECQlMPNACQNGGTCHNSHGGYNCVCVNGWTGEDC 333
Cdd:cd00054      1 DIDECA-SGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
Ank_4 pfam13637
Ankyrin repeats (many copies);
1930-1981 5.23e-07

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 48.42  E-value: 5.23e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 2178034425 1930 TALHLAARYSRSDAAKRLLEASADANIQDNMGRTPLHAAVSADAQGVFQILI 1981
Cdd:pfam13637    3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
EGF_CA smart00179
Calcium-binding EGF-like domain;
946-982 7.07e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 47.63  E-value: 7.07e-07
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 2178034425   946 DINECAS-NPCRHGANCTDCVDSYTCTCPAGFS-GIHCE 982
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
453-489 7.24e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 47.63  E-value: 7.24e-07
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2178034425  453 DVNEC-ISNPCQNEATCLDQIGEFQCICMPGYEGVHCE 489
Cdd:cd00054      1 DIDECaSGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
792-828 1.59e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.48  E-value: 1.59e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2178034425  792 NINECAS-NPCLNQGSCIDDVAGYKCNCPLPYTGATCE 828
Cdd:cd00054      1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
PHA02874 PHA02874
ankyrin repeat protein; Provisional
1873-2097 1.63e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 53.04  E-value: 1.63e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178034425 1873 DVNVRGPDGFTPLMIASCSgggletgNSEEeedapaVISDFIYQGASLhNQTDRTGETALHLAARYSRSDAAKRLLEASA 1952
Cdd:PHA02874   149 DVNIEDDNGCYPIHIAIKH-------NFFD------IIKLLLEKGAYA-NVKDNNGESPLHNAAEYGDYACIKLLIDHGN 214
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178034425 1953 DANIQDNMGRTPLHAAVSADaQGVFQILIRNRA-TDLDArmhDGTTPLILAarlavegmledlINSHADVNAVDdlgksa 2031
Cdd:PHA02874   215 HIMNKCKNGFTPLHNAIIHN-RSAIELLINNASiNDQDI---DGSTPLHHA------------INPPCDIDIID------ 272
                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2178034425 2032 lhwaaavnnveaavVLLKNGANKDMQNNKEETPLFLAARegSYETAKVLLDHFANRDITDHMDRLP 2097
Cdd:PHA02874   273 --------------ILLYHKADISIKDNKGENPIDTAFK--YINKDPVIKDIIANAVLIKEADKLK 322
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
1185-1220 2.11e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.48  E-value: 2.11e-06
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 2178034425 1185 INECVSQ-PCQNGGTCIDLTNTYKCSCPRGTQGVHCE 1220
Cdd:cd00054      2 IDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
1147-1181 2.93e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 46.09  E-value: 2.93e-06
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 2178034425  1147 VDEC-SPSPCQNGATCTDYPGGYSCECVAGYH-GVNC 1181
Cdd:smart00179    2 IDECaSGNPCQNGGTCVNTVGSYRCECPPGYTdGRNC 38
EGF_CA pfam07645
Calcium-binding EGF domain;
413-444 3.18e-06

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 45.69  E-value: 3.18e-06
                           10        20        30
                   ....*....|....*....|....*....|..
gi 2178034425  413 DVDECSLGANPCEHAGKCINTLGSFECQCLQG 444
Cdd:pfam07645    1 DVDECATGTHNCPANTVCVNTIGSFECRCPDG 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
1022-1058 3.30e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 45.70  E-value: 3.30e-06
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 2178034425  1022 DVNECDSR-PCLHGGTCQDSYGTYKCTCPQGYT-GLNCQ 1058
Cdd:smart00179    1 DIDECASGnPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
1230-1266 3.84e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 45.71  E-value: 3.84e-06
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 2178034425 1230 IDPVSRGPKCFNNGTCVDQVGGYSCTCPPGFVGERCE 1266
Cdd:cd00054      2 IDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
529-565 4.30e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 45.32  E-value: 4.30e-06
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 2178034425   529 DVDECAST-PCKNGAKCLDGPNTYTCVCTEGYT-GPHCE 565
Cdd:smart00179    1 DIDECASGnPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
179-217 6.42e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.93  E-value: 6.42e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 2178034425   179 DVNECSQNPrLCQNGGTCHNEVGSYRCTCRT-THTGPHCE 217
Cdd:smart00179    1 DIDECASGN-PCQNGGTCVNTVGSYRCECPPgYTDGRNCE 39
PHA03100 PHA03100
ankyrin repeat protein; Provisional
1922-1986 7.44e-06

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 51.20  E-value: 7.44e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2178034425 1922 NQTDRTGETALHLAARYSRSDAAKRLLEASADANIQDNMGRTPLHAAVSADAQGVFQILIRNRAT 1986
Cdd:PHA03100   186 NIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPS 250
EGF_CA smart00179
Calcium-binding EGF-like domain;
453-489 7.74e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.55  E-value: 7.74e-06
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 2178034425   453 DVNECIS-NPCQNEATCLDQIGEFQCICMPGYE-GVHCE 489
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
908-944 8.83e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.55  E-value: 8.83e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2178034425  908 DVDDCR-PNPCHNGGSCTDGVNTAFCDCLPGFRGPFCE 944
Cdd:cd00054      1 DIDECAsGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
989-1020 1.20e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.16  E-value: 1.20e-05
                           10        20        30
                   ....*....|....*....|....*....|..
gi 2178034425  989 TESSCFNGGTCVDGINSFTCLCPPGFTGSYCQ 1020
Cdd:cd00054      7 SGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
296-333 1.22e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.16  E-value: 1.22e-05
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 2178034425   296 DVDECQlMPNACQNGGTCHNSHGGYNCVCVNGWT-GEDC 333
Cdd:smart00179    1 DIDECA-SGNPCQNGGTCVNTVGSYRCECPPGYTdGRNC 38
JMTM_Notch_APP cd21700
juxtamembrane and transmembrane (JMTM) domain found in Notch and APP family proteins; The ...
1721-1760 1.55e-05

juxtamembrane and transmembrane (JMTM) domain found in Notch and APP family proteins; The substrates of gamma-secretase include amyloid precursor protein (APP) and the Notch receptor. APP, also called APPI, or Alzheimer disease amyloid protein (ABPP), or amyloid precursor protein, or amyloid-beta A4 protein, or cerebral vascular amyloid peptide (CVAP), or PreA4, or protease nexin-II (PN-II), functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Notch proteins are a family of type-1 transmembrane proteins that form a core component of the Notch signaling pathway. They operate in a variety of different tissues and play a role in a variety of developmental processes by controlling cell fate decisions. Successive cleavage of the APP carboxyl-terminal fragment generates amyloid-beta (Abeta) peptides of varying lengths. Accumulation of Abeta peptides such as Abeta42 and Abeta43 leads to formation of amyloid plaques in the brain, a hallmark of Alzheimer's disease. Notch cleavage is involved in cell-fate determination during development and neurogenesis. The model corresponds to the juxtamembrane and transmembrane (JMTM) domain found in Notch and APP family proteins. It comprises a transmembrane helix (TM) with adjacent juxtamembrane (JM) regions. The JMTM domain is likely to be recognized by gamma-secretase in a similar fashion to both Notch and APP family proteins.


Pssm-ID: 411983  Cd Length: 41  Bit Score: 43.92  E-value: 1.55e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 2178034425 1721 VQSETVEPPPPPQLHFMYVAVAAFVLLFFVGCG-VLLSRKR 1760
Cdd:cd21700      1 LPFFALDDGSGKGAIIGLLVGAVVILLVFVITGgLVAARKK 41
EGF_CA smart00179
Calcium-binding EGF-like domain;
1184-1220 1.91e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.77  E-value: 1.91e-05
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 2178034425  1184 EINECVS-QPCQNGGTCIDLTNTYKCSCPRG-TQGVHCE 1220
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGyTDGRNCE 39
PHA03100 PHA03100
ankyrin repeat protein; Provisional
1914-2095 1.97e-05

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 49.66  E-value: 1.97e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178034425 1914 IYQGASLhNQTDRTGETALHLAARYSRS-----DAAKRLLEASADANIQDNMGRTPLHAAVSADAQGVFQI-LIRNRATD 1987
Cdd:PHA03100    55 LDNGADI-NSSTKNNSTPLHYLSNIKYNltdvkEIVKLLLEYGANVNAPDNNGITPLLYAISKKSNSYSIVeYLLDNGAN 133
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178034425 1988 LDARMHDGTTPLilaaRLAVEG------MLEDLINSHADVNA----------------VDDLGKSALHWAAAVNNVEAAV 2045
Cdd:PHA03100   134 VNIKNSDGENLL----HLYLESnkidlkILKLLIDKGVDINAknrvnyllsygvpiniKDVYGFTPLHYAVYNNNPEFVK 209
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|
gi 2178034425 2046 VLLKNGANKDMQNNKEETPLFLAAREGSYETAKVLLDHFANrdiTDHMDR 2095
Cdd:PHA03100   210 YLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPS---IKTIIE 256
PHA02874 PHA02874
ankyrin repeat protein; Provisional
1942-2086 2.66e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 49.19  E-value: 2.66e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178034425 1942 DAAKRLLEASADANIQDNMGRTPLHAAVSADAQGVFQILIRNRAtdldarmhdgttplilaarlavegmledlinshaDV 2021
Cdd:PHA02874   105 DMIKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGA----------------------------------DV 150
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2178034425 2022 NAVDDLGKSALHWAAAVNNVEAAVVLLKNGANKDMQNNKEETPLFLAAREGSYETAKVLLDHFAN 2086
Cdd:PHA02874   151 NIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYACIKLLIDHGNH 215
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
756-790 3.04e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.01  E-value: 3.04e-05
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 2178034425  756 DECES-NPCANGGACRDMTSGYVCTCREGFSGPNCQ 790
Cdd:cd00054      3 DECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
PHA02874 PHA02874
ankyrin repeat protein; Provisional
1970-2115 3.19e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 49.19  E-value: 3.19e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178034425 1970 SADAQGVfQILIRNRATDLDARMHDGTTPLILAARLAVEGMLEDLINSHADVNAVDDLGKSALHWAAAVNNVEAAVVLLK 2049
Cdd:PHA02874    11 SGDIEAI-EKIIKNKGNCINISVDETTTPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLID 89
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178034425 2050 NGA----------NKDM-------------QNNKEETPLFLAAREGSYETAKVLLDHFANRDITDHMDRLPRDIAQERMH 2106
Cdd:PHA02874    90 NGVdtsilpipciEKDMiktildcgidvniKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNF 169

                   ....*....
gi 2178034425 2107 HDIVRLLDE 2115
Cdd:PHA02874   170 FDIIKLLLE 178
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
567-602 3.29e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.01  E-value: 3.29e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2178034425  567 DIDECD-PDPCHY-GVCKDGVATFTCLCRPGYTGHHCE 602
Cdd:cd00054      1 DIDECAsGNPCQNgGTCVNTVGSYRCSCPPGYTGRNCE 38
Ank_5 pfam13857
Ankyrin repeats (many copies);
1947-2002 3.36e-05

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 43.49  E-value: 3.36e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 2178034425 1947 LLEA-SADANIQDNMGRTPLHAAVSADAQGVFQILIRNRAtDLDARMHDGTTPLILA 2002
Cdd:pfam13857    1 LLEHgPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGV-DLNLKDEEGLTALDLA 56
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
683-713 3.44e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 42.76  E-value: 3.44e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 2178034425  683 CAGNPCHHGGTCEDGVNSFTCRCPEGYHGPT 713
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
TRPV3 cd22194
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a ...
1928-2095 3.56e-05

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a temperature-sensitive Transient Receptor Potential (TRP) ion channel that is activated by warm temperatures, synthetic small-molecule chemicals, and natural compounds from plants. TRPV3 function is regulated by physiological factors such as extracellular divalent cations and acidic pH, intracellular adenosine triphosphate, membrane voltage, and arachidonic acid. It is expressed in both neuronal and non-neuronal tissues including epidermal keratinocytes, epithelial cells in the gut, endothelial cells in blood vessels, and neurons in dorsal root ganglia and CNS. TRPV3 null mice have abnormal hair morphogenesis and compromised skin barrier function. It may play roles in inflammatory skin disorders, such as itch and pain sensation. TRPV3 is also expressed by many neuronal and non-neuronal tissues, showing that TRPV3 might play roles in other unknown cellular and physiological functions. TRPV3 belongs to the vanilloid TRP subfamily (TRPV), named after the founding member vanilloid receptor 1 (TRPV1). The structure of TRPV shows the typical topology features of all TRP ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.


Pssm-ID: 411978 [Multi-domain]  Cd Length: 680  Bit Score: 49.37  E-value: 3.56e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178034425 1928 GETALHLAARYSRSDAAKRLLEASADANIQdnmgrtplhaavsadAQGVFqilirNRATDLDARMHDGTTPLILAA---R 2004
Cdd:cd22194    141 GQTALNIAIERRQGDIVKLLIAKGADVNAH---------------AKGVF-----FNPKYKHEGFYFGETPLALAActnQ 200
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178034425 2005 LAVEGMLEDliNSHADVNAVDDLGKSALHWAAAVNNVEAAVV---------LLKNGANKD---MQNNKEETPLFLAAREG 2072
Cdd:cd22194    201 PEIVQLLME--KESTDITSQDSRGNTVLHALVTVAEDSKTQNdfvkrmydmILLKSENKNletIRNNEGLTPLQLAAKMG 278
                          170       180
                   ....*....|....*....|...
gi 2178034425 2073 SYEtakvLLDHFANRDITDHMDR 2095
Cdd:cd22194    279 KAE----ILKYILSREIKEKPNR 297
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
533-563 4.99e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 42.37  E-value: 4.99e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 2178034425  533 CASTPCKNGAKCLDGPNTYTCVCTEGYTGPH 563
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
258-294 5.59e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.24  E-value: 5.59e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2178034425  258 NVDDC-PGNNCKNGGACVDGVNTYNCRCPPEWTGQYCT 294
Cdd:cd00054      1 DIDECaSGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
604-640 6.05e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.24  E-value: 6.05e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2178034425  604 NINECHSQ-PCRHGGTCQDRDNAYLCSCLKGTTGPNCE 640
Cdd:cd00054      1 DIDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
1026-1056 6.90e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 41.98  E-value: 6.90e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 2178034425 1026 CDSRPCLHGGTCQDSYGTYKCTCPQGYTGLN 1056
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
TRPV cd21882
Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily ...
1927-2102 7.82e-05

Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily (TRPV), named after the vanilloid receptor 1 (TRPV1), consists of six members: four thermo-sensing channels (TRPV1, TRPV2, TRPV3, and TRPV4) and two Ca2+ selective channels (TRPV5 and TRPV6). The calcium-selective channels TRPV5 and TRPV6 can be heterotetramers and are important for general Ca2+ homeostasis. All four channels within the TRPV1-4 group show temperature-invoked currents when expressed in heterologous cell systems, ranging from activation at ~25C for TRPV4 to ~52C for TRPV2. The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains. The TRP family consists of membrane proteins that function as ion channels that communicate between the cell and its environment, by a vast array of physical or chemical stimuli, including radiation (in the form of temperature, infrared ,or light) and pressure (osmotic or mechanical). TRP channels are formed by a tetrameric complex of channel subunits. Based on sequence identity, the mammalian TRP channel family is classified into six subfamilies, with significant sequence similarity within the transmembrane domains, but very low similarity in their N- and C-terminal cytoplasmic regions. The six subfamilies are named based on their first member: TRPC (canonical), TRPV (vanilloid), TRPM (melastatin), TRPA (ankyrin), TRPML (mucolipin), and TRPP (polycystic).


Pssm-ID: 411975 [Multi-domain]  Cd Length: 600  Bit Score: 47.95  E-value: 7.82e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178034425 1927 TGETALHLAARY---SRSDAAKRLLEASADANIQDNM-----------GRTPLHAAVSADAQGVFQILIRNRAtDLDAR- 1991
Cdd:cd21882     25 TGKTCLHKAALNlndGVNEAIMLLLEAAPDSGNPKELvnapctdefyqGQTALHIAIENRNLNLVRLLVENGA-DVSARa 103
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178034425 1992 ------------MHDGTTPLILAARLAVEGMLEDLI-NSH--ADVNAVDDLGKSALH---------WAAAVNNVEAAVVL 2047
Cdd:cd21882    104 tgrffrkspgnlFYFGELPLSLAACTNQEEIVRLLLeNGAqpAALEAQDSLGNTVLHalvlqadntPENSAFVCQMYNLL 183
                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2178034425 2048 LKNGANKD-------MQNNKEETPLFLAAREGSYetakVLLDHFANRDITDHMDRLPRDIAQ 2102
Cdd:cd21882    184 LSYGAHLDptqqleeIPNHQGLTPLKLAAVEGKI----VMFQHILQREFSGPYQPLSRKFTE 241
EGF_CA smart00179
Calcium-binding EGF-like domain;
792-828 9.94e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.46  E-value: 9.94e-05
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 2178034425   792 NINECAS-NPCLNQGSCIDDVAGYKCNCPLPYT-GATCE 828
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
1268-1306 1.19e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.47  E-value: 1.19e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 2178034425 1268 DVNECLS-NPCDARGTqnCVQRVNDFYCECRAGHTGRRCE 1306
Cdd:cd00054      1 DIDECASgNPCQNGGT--CVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
143-176 1.30e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.08  E-value: 1.30e-04
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 2178034425  143 DPCAS-NPCANGGQCLPFEASYICGCPHGFHGPTC 176
Cdd:cd00054      3 DECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA pfam07645
Calcium-binding EGF domain;
179-208 2.07e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 40.68  E-value: 2.07e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 2178034425  179 DVNECSQNPRLCQNGGTCHNEVGSYRCTCR 208
Cdd:pfam07645    1 DVDECATGTHNCPANTVCVNTIGSFECRCP 30
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
1923-2021 2.27e-04

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 46.54  E-value: 2.27e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178034425 1923 QTDRTGETALHLAARYSRSDAAKRLLE-ASADANIQDNMGRTPLHAAVSADAQGVFQILIRNrATDL-----DARMHDGT 1996
Cdd:cd22192     12 QQKRISESPLLLAAKENDVQAIKKLLKcPSCDLFQRGALGETALHVAALYDNLEAAVVLMEA-APELvnepmTSDLYQGE 90
                           90       100
                   ....*....|....*....|....*
gi 2178034425 1997 TPLILAARLAVEGMLEDLINSHADV 2021
Cdd:cd22192     91 TALHIAVVNQNLNLVRELIARGADV 115
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
1150-1180 2.78e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 40.06  E-value: 2.78e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 2178034425 1150 CSPSPCQNGATCTDYPGGYSCECVAGYHGVN 1180
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA pfam07645
Calcium-binding EGF domain;
296-327 2.78e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 40.30  E-value: 2.78e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 2178034425  296 DVDECQLMPNACQNGGTCHNSHGGYNCVCVNG 327
Cdd:pfam07645    1 DVDECATGTHNCPANTVCVNTIGSFECRCPDG 32
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
1922-1990 3.47e-04

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 46.04  E-value: 3.47e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2178034425 1922 NQTDRTGETALHLAARYSRSDAAKRLLEASADANIQDNMGRTPLHAAVSADAQGVFQILIRNRATDLDA 1990
Cdd:PTZ00322   109 NCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRHSQCHFEL 177
EGF_CA smart00179
Calcium-binding EGF-like domain;
604-640 3.50e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.92  E-value: 3.50e-04
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 2178034425   604 NINECHS-QPCRHGGTCQDRDNAYLCSCLKG-TTGPNCE 640
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGyTDGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
908-944 4.26e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.92  E-value: 4.26e-04
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 2178034425   908 DVDDC-RPNPCHNGGSCTDGVNTAFCDCLPGFR-GPFCE 944
Cdd:smart00179    1 DIDECaSGNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
1222-1266 4.43e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.92  E-value: 4.43e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 2178034425  1222 NVDDCSppidpvSRGPkCFNNGTCVDQVGGYSCTCPPGFV-GERCE 1266
Cdd:smart00179    1 DIDECA------SGNP-CQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
TRPV1-4 cd22193
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 1-4; TRPV1-4 are ...
1928-2101 4.81e-04

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 1-4; TRPV1-4 are thermo-sensing channels that function directly in temperature-sensing and nociception; they share substantial structural and functional properties. Transient Receptor Potential (TRP) ion channels activated by temperature (thermo TRPs) are important molecular players in acute, inflammatory, and chronic pain states. So far, 11 TRP channels in mammalian cells have been identified as thermosensitive TRP (thermo-TRP) channels. TRPV1-4 channels are activated by different heat temperatures, for example, TRPV1 and TRPV2 are activated by high temperatures (>43C and >55C, respectively). TRPV1-4 belong to the vanilloid TRP subfamily (TRPV), named after the founding member vanilloid receptor 1 (TRPV1). The structure of TRPV shows the typical topology features of all TRP ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.


Pssm-ID: 411977 [Multi-domain]  Cd Length: 607  Bit Score: 45.56  E-value: 4.81e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178034425 1928 GETALHLAARYSRSDAAKRLLEASADANIQDN--------------MGRTPLHAAVSADAQGVFQILIRNRATDLDARMH 1993
Cdd:cd22193     76 GQTALHIAIERRQGDIVALLVENGADVHAHAKgrffqpkyqgegfyFGELPLSLAACTNQPDIVQYLLENEHQPADIEAQ 155
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178034425 1994 DGTTPLILAARLAVEgmlEDLINSHADVNAVDDLgksalhwaaavnnveaavvLLKNGAN-------KDMQNNKEETPLF 2066
Cdd:cd22193    156 DSRGNTVLHALVTVA---DNTKENTKFVTRMYDM-------------------ILIRGAKlcptvelEEIRNNDGLTPLQ 213
                          170       180       190
                   ....*....|....*....|....*....|....*....
gi 2178034425 2067 LAAREGSYEtakvLLDHFANRDITD----HMDRLPRDIA 2101
Cdd:cd22193    214 LAAKMGKIE----ILKYILQREIKEpelrHLSRKFTDWA 248
EGF_CA smart00179
Calcium-binding EGF-like domain;
993-1020 4.93e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.54  E-value: 4.93e-04
                            10        20
                    ....*....|....*....|....*....
gi 2178034425   993 CFNGGTCVDGINSFTCLCPPGFT-GSYCQ 1020
Cdd:smart00179   11 CQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
2047-2149 5.18e-04

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 45.27  E-value: 5.18e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178034425 2047 LLKNGANKDMQNNKEETPLFLAAREGSYETAKVLLDHFANRDITDHMDRLPRDIAQERMHHDIVRLL------------- 2113
Cdd:PTZ00322   101 LLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLsrhsqchfelgan 180
                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 2178034425 2114 ---DEYSLVRSPQLHGPALGGAPTLSPplcSPNGYLGNL 2149
Cdd:PTZ00322   181 akpDSFTGKPPSLEDSPISSHHPDFSA---VPQPMMGSL 216
PHA02878 PHA02878
ankyrin repeat protein; Provisional
1909-2116 5.25e-04

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 45.26  E-value: 5.25e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178034425 1909 VISDFIYQGASLhNQTDRTGETALHLAARYSRSDAAKRLLEASadanIQDNMGRT--PLHAAVSADAQGVFQILIRNRAT 1986
Cdd:PHA02878    52 VVKSLLTRGHNV-NQPDHRDLTPLHIICKEPNKLGMKEMIRSI----NKCSVFYTlvAIKDAFNNRNVEIFKIILTNRYK 126
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178034425 1987 DLdaRMHDGTTPLILAARLAVEGMLEDLINSH-ADVNAVD-DLGKSALHWAAAVNNVEAAVVLLKNGANKDMQNNKEETP 2064
Cdd:PHA02878   127 NI--QTIDLVYIDKKSKDDIIEAEITKLLLSYgADINMKDrHKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSP 204
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2178034425 2065 LFLAAREGSYETAKVLLDHFANRDITDHMDRLPRDIAQER-MHHDIVRLLDEY 2116
Cdd:PHA02878   205 LHHAVKHYNKPIVHILLENGASTDARDKCGNTPLHISVGYcKDYDILKLLLEH 257
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
718-751 5.47e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.54  E-value: 5.47e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 2178034425  718 VNECSS-DPCIHGA-CRDSLNGYKCDCDPGWSGANC 751
Cdd:cd00054      2 IDECASgNPCQNGGtCVNTVGSYRCSCPPGYTGRNC 37
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
1928-1959 5.50e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 39.19  E-value: 5.50e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 2178034425 1928 GETALHLAA-RYSRSDAAKRLLEASADANIQDN 1959
Cdd:pfam00023    2 GNTPLHLAAgRRGNLEIVKLLLSKGADVNARDK 34
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
336-371 6.46e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.16  E-value: 6.46e-04
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 2178034425  336 NIDDCASAA-CFHGATCHDRVASFYCECPHGRTGLLC 371
Cdd:cd00054      1 DIDECASGNpCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
682-713 7.76e-04

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 39.00  E-value: 7.76e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 2178034425  682 ECA-GNPCHHGGTCEDGVNSFTCRCPEGYHGPT 713
Cdd:cd00053      1 ECAaSNPCSNGGTCVNTPGSYRCVCPPGYTGDR 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
567-602 9.44e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.77  E-value: 9.44e-04
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 2178034425   567 DIDEC-DPDPCHYG-VCKDGVATFTCLCRPGYT-GHHCE 602
Cdd:smart00179    1 DIDECaSGNPCQNGgTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA pfam07645
Calcium-binding EGF domain;
870-899 9.60e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 38.76  E-value: 9.60e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 2178034425  870 DINECV--KSPCRNGASCQNTNGGYRCRCRAG 899
Cdd:pfam07645    1 DVDECAtgTHNCPANTVCVNTIGSFECRCPDG 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
756-790 1.01e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.77  E-value: 1.01e-03
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 2178034425   756 DECES-NPCANGGACRDMTSGYVCTCREGFS-GPNCQ 790
Cdd:smart00179    3 DECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
491-527 1.08e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.77  E-value: 1.08e-03
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2178034425  491 NTDECAS-SPCLQNGRCLDKINEFLCECSTGFTGHLCQ 527
Cdd:cd00054      1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
796-826 1.34e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 38.13  E-value: 1.34e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 2178034425  796 CASNPCLNQGSCIDDVAGYKCNCPLPYTGAT 826
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
1928-1956 1.54e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 38.01  E-value: 1.54e-03
                           10        20
                   ....*....|....*....|....*....
gi 2178034425 1928 GETALHLAARYSRSDAAKRLLEASADANI 1956
Cdd:pfam13606    2 GNTPLHLAARNGRLEIVKLLLENGADINA 30
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
988-1018 1.68e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 38.13  E-value: 1.68e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 2178034425  988 CTESSCFNGGTCVDGINSFTCLCPPGFTGSY 1018
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
262-292 1.82e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 37.75  E-value: 1.82e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 2178034425  262 CPGNNCKNGGACVDGVNTYNCRCPPEWTGQY 292
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
hEGF pfam12661
Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six ...
993-1014 2.04e-03

Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six conserved residues disulfide-bonded into the characteriztic 'ababcc' pattern. They are involved in growth and proliferation of cells, in proteins of the Notch/Delta pathway, neurogulin and selectins. hEGFs are also found in mosaic proteins with four-disulfide laminin EGFs such as aggrecan and perlecan. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal Cys residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In hEGFs the C-terminal thiol resides in the beta-turn, resulting in shorter loop-lengths between the Cys residues of disulfide 'c', typically C[8-9]XC. These shorter loop-lengths are also typical of the four-disulfide EGF domains, laminin ad integrin. Tandem hEGF domains have six linking residues between terminal cysteines of adjacent domains. hEGF domains may or may not bind calcium in the linker region. hEGF domains with the consensus motif CXD4X[F,Y]XCXC are hydroxylated exclusively in the Asp residue.


Pssm-ID: 463660  Cd Length: 22  Bit Score: 37.70  E-value: 2.04e-03
                           10        20
                   ....*....|....*....|..
gi 2178034425  993 CFNGGTCVDGINSFTCLCPPGF 1014
Cdd:pfam12661    1 CQNGGTCVDGVNGYKCQCPPGY 22
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
145-175 2.17e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 37.75  E-value: 2.17e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 2178034425  145 CASNPCANGGQCLPFEASYICGCPHGFHGPT 175
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
877-906 2.29e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 37.84  E-value: 2.29e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 2178034425  877 SPCRNGASCQNTNGGYRCRCRAGYTG-HNCE 906
Cdd:cd00053      6 NPCSNGGTCVNTPGSYRCVCPPGYTGdRSCE 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
336-365 2.43e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.61  E-value: 2.43e-03
                            10        20        30
                    ....*....|....*....|....*....|.
gi 2178034425   336 NIDDCASAA-CFHGATCHDRVASFYCECPHG 365
Cdd:smart00179    1 DIDECASGNpCQNGGTCVNTVGSYRCECPPG 31
PHA02946 PHA02946
ankyin-like protein; Provisional
1879-2033 2.60e-03

ankyin-like protein; Provisional


Pssm-ID: 165256 [Multi-domain]  Cd Length: 446  Bit Score: 42.73  E-value: 2.60e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178034425 1879 PDGFTPLMIASCSGGGLETGNSEEeedapavisdFIYQGASlHNQTDRTGETALHLAARYSRSDAAKRLLEASADANIQD 1958
Cdd:PHA02946    34 PSGNYHILHAYCGIKGLDERFVEE----------LLHRGYS-PNETDDDGNYPLHIASKINNNRIVAMLLTHGADPNACD 102
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2178034425 1959 NMGRTPLHAAVSADAQGVFQI--LIRNRATDLDARMHDGTTPLiLAARLAVEGMLEDLINSHADVNAVDDLGKSALH 2033
Cdd:PHA02946   103 KQHKTPLYYLSGTDDEVIERInlLVQYGAKINNSVDEEGCGPL-LACTDPSERVFKKIMSIGFEARIVDKFGKNHIH 178
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
912-942 2.97e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 37.36  E-value: 2.97e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 2178034425  912 CRPNPCHNGGSCTDGVNTAFCDCLPGFRGPF 942
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
PRK14950 PRK14950
DNA polymerase III subunits gamma and tau; Provisional
2449-2532 3.00e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237864 [Multi-domain]  Cd Length: 585  Bit Score: 42.87  E-value: 3.00e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178034425 2449 PSQADVQPLGPSSLAVHTILPQDSQALPTALPATLAPPMTTAQFLTPPsqhsyssSPADNTPSHQLQVPEHPFLTPSPES 2528
Cdd:PRK14950   378 PVRPTPAPSTRPKAAAAANIPPKEPVRETATPPPVPPRPVAPPVPHTP-------ESAPKLTRAAIPVDEKPKYTPPAPP 450

                   ....
gi 2178034425 2529 PDQW 2532
Cdd:PRK14950   451 KEEE 454
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
1149-1180 3.08e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 37.46  E-value: 3.08e-03
                           10        20        30
                   ....*....|....*....|....*....|...
gi 2178034425 1149 ECS-PSPCQNGATCTDYPGGYSCECVAGYHGVN 1180
Cdd:cd00053      1 ECAaSNPCSNGGTCVNTPGSYRCVCPPGYTGDR 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
1316-1347 3.65e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.23  E-value: 3.65e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 2178034425 1316 PCQNGGTCavaSNTARGFICKCPAGFEGATCE 1347
Cdd:cd00054     10 PCQNGGTC---VNTVGSYRCSCPPGYTGRNCE 38
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
416-449 4.10e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 37.07  E-value: 4.10e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 2178034425  416 ECSLGaNPCEHAGKCINTLGSFECQCLQGYTGPR 449
Cdd:cd00053      1 ECAAS-NPCSNGGTCVNTPGSYRCVCPPGYTGDR 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
258-294 4.22e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.84  E-value: 4.22e-03
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 2178034425   258 NVDDC-PGNNCKNGGACVDGVNTYNCRCPPEWT-GQYCT 294
Cdd:smart00179    1 DIDECaSGNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
224-256 4.67e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.85  E-value: 4.67e-03
                           10        20        30
                   ....*....|....*....|....*....|...
gi 2178034425  224 SPSPCQNGGTCRPTGDTtHECACLPGFTGQNCE 256
Cdd:cd00054      7 SGNPCQNGGTCVNTVGS-YRCSCPPGYTGRNCE 38
hEGF pfam12661
Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six ...
1239-1260 4.92e-03

Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six conserved residues disulfide-bonded into the characteriztic 'ababcc' pattern. They are involved in growth and proliferation of cells, in proteins of the Notch/Delta pathway, neurogulin and selectins. hEGFs are also found in mosaic proteins with four-disulfide laminin EGFs such as aggrecan and perlecan. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal Cys residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In hEGFs the C-terminal thiol resides in the beta-turn, resulting in shorter loop-lengths between the Cys residues of disulfide 'c', typically C[8-9]XC. These shorter loop-lengths are also typical of the four-disulfide EGF domains, laminin ad integrin. Tandem hEGF domains have six linking residues between terminal cysteines of adjacent domains. hEGF domains may or may not bind calcium in the linker region. hEGF domains with the consensus motif CXD4X[F,Y]XCXC are hydroxylated exclusively in the Asp residue.


Pssm-ID: 463660  Cd Length: 22  Bit Score: 36.54  E-value: 4.92e-03
                           10        20
                   ....*....|....*....|..
gi 2178034425 1239 CFNNGTCVDQVGGYSCTCPPGF 1260
Cdd:pfam12661    1 CQNGGTCVDGVNGYKCQCPPGY 22
PHA02874 PHA02874
ankyrin repeat protein; Provisional
1930-2113 5.00e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 41.87  E-value: 5.00e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178034425 1930 TALHLAARYSRSDAAKRLLEASADANIQDNMGRTPLHAAVSADAQGVFQILIRNratdldarmhdGTTPLILAARLAVEG 2009
Cdd:PHA02874    37 TPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLIDN-----------GVDTSILPIPCIEKD 105
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178034425 2010 MLEDLINSHADVNAVDDLGKSALHWAAAVNNVEAAVVLLKNGANKDMQNNKEETPLFLAAREGSYETAKVLLDHFANRDI 2089
Cdd:PHA02874   106 MIKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANV 185
                          170       180
                   ....*....|....*....|....
gi 2178034425 2090 TDHMDRLPRDIAQERMHHDIVRLL 2113
Cdd:PHA02874   186 KDNNGESPLHNAAEYGDYACIKLL 209
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
1239-1264 5.14e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 36.69  E-value: 5.14e-03
                           10        20
                   ....*....|....*....|....*.
gi 2178034425 1239 CFNNGTCVDQVGGYSCTCPPGFVGER 1264
Cdd:cd00053      8 CSNGGTCVNTPGSYRCVCPPGYTGDR 33
PHA03100 PHA03100
ankyrin repeat protein; Provisional
1981-2091 5.32e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 41.96  E-value: 5.32e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178034425 1981 IRNRATDLDARMHDGTTPLILAARLAVEGMLEDLINSHADVNAVDDLGKSALHWAAAVNNVEAAVV-----LLKNGANKD 2055
Cdd:PHA03100    21 IIMEDDLNDYSYKKPVLPLYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHYLSNIKYNLTDVKeivklLLEYGANVN 100
                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 2178034425 2056 MQNNKEETPLFLAARE--GSYETAKVLLDHFANRDITD 2091
Cdd:PHA03100   101 APDNNGITPLLYAISKksNSYSIVEYLLDNGANVNIKN 138
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
422-449 5.57e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.59  E-value: 5.57e-03
                           10        20
                   ....*....|....*....|....*...
gi 2178034425  422 NPCEHAGKCINTLGSFECQCLQGYTGPR 449
Cdd:pfam00008    4 NPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
993-1017 6.32e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 36.30  E-value: 6.32e-03
                           10        20
                   ....*....|....*....|....*
gi 2178034425  993 CFNGGTCVDGINSFTCLCPPGFTGS 1017
Cdd:cd00053      8 CSNGGTCVNTPGSYRCVCPPGYTGD 32
hEGF pfam12661
Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six ...
688-709 6.74e-03

Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six conserved residues disulfide-bonded into the characteriztic 'ababcc' pattern. They are involved in growth and proliferation of cells, in proteins of the Notch/Delta pathway, neurogulin and selectins. hEGFs are also found in mosaic proteins with four-disulfide laminin EGFs such as aggrecan and perlecan. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal Cys residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In hEGFs the C-terminal thiol resides in the beta-turn, resulting in shorter loop-lengths between the Cys residues of disulfide 'c', typically C[8-9]XC. These shorter loop-lengths are also typical of the four-disulfide EGF domains, laminin ad integrin. Tandem hEGF domains have six linking residues between terminal cysteines of adjacent domains. hEGF domains may or may not bind calcium in the linker region. hEGF domains with the consensus motif CXD4X[F,Y]XCXC are hydroxylated exclusively in the Asp residue.


Pssm-ID: 463660  Cd Length: 22  Bit Score: 36.16  E-value: 6.74e-03
                           10        20
                   ....*....|....*....|..
gi 2178034425  688 CHHGGTCEDGVNSFTCRCPEGY 709
Cdd:pfam12661    1 CQNGGTCVDGVNGYKCQCPPGY 22
PHA02917 PHA02917
ankyrin-like protein; Provisional
1922-1970 6.76e-03

ankyrin-like protein; Provisional


Pssm-ID: 165231 [Multi-domain]  Cd Length: 661  Bit Score: 41.91  E-value: 6.76e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 2178034425 1922 NQTDRTGETALHLAARYSRSDAAKRLLEASADANIQDNMGRTPLHAAVS 1970
Cdd:PHA02917   446 NMIDKRGETLLHKAVRYNKQSLVSLLLESGSDVNIRSNNGYTCIAIAIN 494
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
299-331 6.77e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 36.30  E-value: 6.77e-03
                           10        20        30
                   ....*....|....*....|....*....|...
gi 2178034425  299 ECQLmPNACQNGGTCHNSHGGYNCVCVNGWTGE 331
Cdd:cd00053      1 ECAA-SNPCSNGGTCVNTPGSYRCVCPPGYTGD 32
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
1025-1054 6.90e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 36.30  E-value: 6.90e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 2178034425 1025 ECD-SRPCLHGGTCQDSYGTYKCTCPQGYTG 1054
Cdd:cd00053      1 ECAaSNPCSNGGTCVNTPGSYRCVCPPGYTG 31
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
1064-1094 7.34e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.21  E-value: 7.34e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 2178034425 1064 CDSSPCKNGGRCWQTNTRYRCECHSGWTGLY 1094
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
717-752 7.92e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.07  E-value: 7.92e-03
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 2178034425   717 EVNECSS-DPCIHGA-CRDSLNGYKCDCDPGWS-GANCD 752
Cdd:smart00179    1 DIDECASgNPCQNGGtCVNTVGSYRCECPPGYTdGRNCE 39
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
2005-2129 8.19e-03

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 41.78  E-value: 8.19e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178034425 2005 LAVEGMLEDLINSHADVN------AVDDLGKSALhwaaavnnveaAVVLLKNGANKDMQNNKEETPLFLAAREGSYETAK 2078
Cdd:PLN03192   507 LNVGDLLGDNGGEHDDPNmasnllTVASTGNAAL-----------LEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVL 575
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2178034425 2079 VLLDHFANRDITDHMDRLPRDIAQERMHHDIVRLLDEYSLVRSPQLHGPAL 2129
Cdd:PLN03192   576 VLLKHACNVHIRDANGNTALWNAISAKHHKIFRILYHFASISDPHAAGDLL 626
EGF_CA smart00179
Calcium-binding EGF-like domain;
1268-1306 8.49e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.07  E-value: 8.49e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 2178034425  1268 DVNECLS-NPCDARGTqnCVQRVNDFYCECRAGHT-GRRCE 1306
Cdd:smart00179    1 DIDECASgNPCQNGGT--CVNTVGSYRCECPPGYTdGRNCE 39
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
1188-1218 8.68e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 35.82  E-value: 8.68e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 2178034425 1188 CVSQPCQNGGTCIDLTNTYKCSCPRGTQGVH 1218
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
143-176 9.18e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.07  E-value: 9.18e-03
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 2178034425   143 DPCAS-NPCANGGQCLPFEASYICGCPHGFH-GPTC 176
Cdd:smart00179    3 DECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNC 38
PHA02743 PHA02743
Viral ankyrin protein; Provisional
1913-2030 9.36e-03

Viral ankyrin protein; Provisional


Pssm-ID: 222925 [Multi-domain]  Cd Length: 166  Bit Score: 39.41  E-value: 9.36e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178034425 1913 FIYQGASLHNQTDRTGETALHLAARYSRSDAAKR---LLEASADANIQD-NMGRTPLHAAVSADAQGVFQILIRNRATDL 1988
Cdd:PHA02743    42 FISGDGHLLHRYDHHGRQCTHMVAWYDRANAVMKielLVNMGADINARElGTGNTLLHIAASTKNYELAEWLCRQLGVNL 121
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 2178034425 1989 DARMHDGTTPLILAARLAVEGMLEDLINSHADVNAVDDLGKS 2030
Cdd:PHA02743   122 GAINYQHETAYHIAYKMRDRRMMEILRANGAVCDDPLSIGLS 163
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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