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Conserved domains on  [gi|2215954558|ref|XP_047236095|]
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COMM domain-containing protein 7 isoform X2 [Girardinichthys multiradiatus]

Protein Classification

COMM domain-containing protein 7( domain architecture ID 10140835)

COMM domain-containing protein 7 (COMMD7) may modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes and associates with the NF-kappa-B complex and suppresses its transcriptional activity

Gene Symbol:  COMMD7
Gene Ontology:  GO:0051059|GO:0006355
PubMed:  15799966
SCOP:  4005215

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Commd7 cd04755
COMM_Domain containing protein 7. The COMM Domain is found at the C-terminus of a variety of ...
 62-240 2.76e-109

COMM_Domain containing protein 7. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


:

Pssm-ID: 240103  Cd Length: 180  Bit Score: 312.08  E-value: 2.76e-109
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2215954558  62 FQNLCKF-DEQFRHLIEILFQFLLDPKETNRFMQRLTEFAGEHGMSAGPLRNLMKSVLLVPQGALKKNLTTDQVKEDLIT 140
Cdd:cd04755     1 IQNLNQLsEQQFSRLTEILFEFLLEPKESERLLNQLDEFAGENGISLGPLKNIVKSILLVPNGALKRNLTAEQLREDLIQ 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2215954558 141 LGLNEEKAAHFSLQWGEHYAALSRLAVGQTLMVNQLVDMEWKFGVTVGTSEIQKVGNIFLQLKLVVRKGNSTENVFMELT 220
Cdd:cd04755    81 LGLSEEKASYFSEQWKQHYSTLSRSAVGQTLMVNQLVDMEWKFGVTAGSSELQKVGSIFLQLKLVVRKGNQTENVYMELT 160

                         170       180
                  ....*....|....*....|
gi 2215954558 221 LPQFYNFLHEMERAKASMEC 240
Cdd:cd04755   161 LPQFYSFLHEMERAKASLEC 180
 
Name Accession Description Interval E-value
Commd7 cd04755
COMM_Domain containing protein 7. The COMM Domain is found at the C-terminus of a variety of ...
 62-240 2.76e-109

COMM_Domain containing protein 7. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


Pssm-ID: 240103  Cd Length: 180  Bit Score: 312.08  E-value: 2.76e-109
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2215954558  62 FQNLCKF-DEQFRHLIEILFQFLLDPKETNRFMQRLTEFAGEHGMSAGPLRNLMKSVLLVPQGALKKNLTTDQVKEDLIT 140
Cdd:cd04755     1 IQNLNQLsEQQFSRLTEILFEFLLEPKESERLLNQLDEFAGENGISLGPLKNIVKSILLVPNGALKRNLTAEQLREDLIQ 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2215954558 141 LGLNEEKAAHFSLQWGEHYAALSRLAVGQTLMVNQLVDMEWKFGVTVGTSEIQKVGNIFLQLKLVVRKGNSTENVFMELT 220
Cdd:cd04755    81 LGLSEEKASYFSEQWKQHYSTLSRSAVGQTLMVNQLVDMEWKFGVTAGSSELQKVGSIFLQLKLVVRKGNQTENVYMELT 160

                         170       180
                  ....*....|....*....|
gi 2215954558 221 LPQFYNFLHEMERAKASMEC 240
Cdd:cd04755   161 LPQFYSFLHEMERAKASLEC 180
COMM_domain pfam07258
COMM domain; The leucine-rich, 70-85 amino acid long COMM domain is predicted to form a ...
 172-234 4.42e-16

COMM domain; The leucine-rich, 70-85 amino acid long COMM domain is predicted to form a beta-sheet and an extreme C-terminal alpha- helix. The COMM domain containing proteins are about 200 residues in length and passed the C-terminal COMM domain.


Pssm-ID: 462125  Cd Length: 64  Bit Score: 70.27  E-value: 4.42e-16
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2215954558 172 MVNQLVDMEWKFGVTVGTSEIQKVGNIFLQLKLVVRKG-NSTENVFMELTLPQFYNFLHEMERA 234
Cdd:pfam07258   1 SLPQLVDLDWRLDVQLSSSSLSKVNEPVVLLELKLSDGdGSSEEVTFELSKEQLQDLLNELEEA 64
 
Name Accession Description Interval E-value
Commd7 cd04755
COMM_Domain containing protein 7. The COMM Domain is found at the C-terminus of a variety of ...
 62-240 2.76e-109

COMM_Domain containing protein 7. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


Pssm-ID: 240103  Cd Length: 180  Bit Score: 312.08  E-value: 2.76e-109
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2215954558  62 FQNLCKF-DEQFRHLIEILFQFLLDPKETNRFMQRLTEFAGEHGMSAGPLRNLMKSVLLVPQGALKKNLTTDQVKEDLIT 140
Cdd:cd04755     1 IQNLNQLsEQQFSRLTEILFEFLLEPKESERLLNQLDEFAGENGISLGPLKNIVKSILLVPNGALKRNLTAEQLREDLIQ 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2215954558 141 LGLNEEKAAHFSLQWGEHYAALSRLAVGQTLMVNQLVDMEWKFGVTVGTSEIQKVGNIFLQLKLVVRKGNSTENVFMELT 220
Cdd:cd04755    81 LGLSEEKASYFSEQWKQHYSTLSRSAVGQTLMVNQLVDMEWKFGVTAGSSELQKVGSIFLQLKLVVRKGNQTENVYMELT 160

                         170       180
                  ....*....|....*....|
gi 2215954558 221 LPQFYNFLHEMERAKASMEC 240
Cdd:cd04755   161 LPQFYSFLHEMERAKASLEC 180
Commd cd04748
COMM_Domain, a family of domains found at the C-terminus of HCarG, the copper metabolism gene ...
 154-238 8.43e-25

COMM_Domain, a family of domains found at the C-terminus of HCarG, the copper metabolism gene MURR1 product, and related proteins. Presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB. Murr1/Commd1 is a protein involved in copper homeostasis, which has also been identified as a regulator of the human delta epithelial sodium channel. HCaRG, a nuclear protein that might be involved in cell proliferation, is negatively regulated by extracellular calcium concentration, and its basal mRNA levels are higher in hypertensive animals.


Pssm-ID: 240096  Cd Length: 87  Bit Score: 93.91  E-value: 8.43e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2215954558 154 QWGEHYAALSRLAVGQTLMVNQLVDMEWKFGVTVGTSEIQKVGN--IFLQLKLVVRKGNSTENVFMELTLPQFYNFLHEM 231
Cdd:cd04748     1 LLTENKAEIEELLSKQSLSLPQLVDFDWRLDVQISSSSLAKVKQptILVQLKLQVGDNNSSEKICFEMTKEELQNFLNKL 80


                  ....*..
gi 2215954558 232 ERAKASM 238
Cdd:cd04748    81 KKIKAQL 87
COMM_domain pfam07258
COMM domain; The leucine-rich, 70-85 amino acid long COMM domain is predicted to form a ...
 172-234 4.42e-16

COMM domain; The leucine-rich, 70-85 amino acid long COMM domain is predicted to form a beta-sheet and an extreme C-terminal alpha- helix. The COMM domain containing proteins are about 200 residues in length and passed the C-terminal COMM domain.


Pssm-ID: 462125  Cd Length: 64  Bit Score: 70.27  E-value: 4.42e-16
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2215954558 172 MVNQLVDMEWKFGVTVGTSEIQKVGNIFLQLKLVVRKG-NSTENVFMELTLPQFYNFLHEMERA 234
Cdd:pfam07258   1 SLPQLVDLDWRLDVQLSSSSLSKVNEPVVLLELKLSDGdGSSEEVTFELSKEQLQDLLNELEEA 64
Commd4 cd04752
COMM_Domain containing protein 4. The COMM Domain is found at the C-terminus of a variety of ...
 124-239 6.46e-11

COMM_Domain containing protein 4. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


Pssm-ID: 240100 [Multi-domain]  Cd Length: 174  Bit Score: 59.37  E-value: 6.46e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2215954558 124 ALKKNLTTDQVKEDLITLGLNEEKAAHFSLQWGEHYAALSRLAVGQTLMVNQLVDMEWKFGVTVGTSEIQKVGNIFLQLK 203
Cdd:cd04752    55 AAKYNVDGESLSSELQQLGLPKEHATSLCRSYEEKQSKLQESLRANSLRLSRLESVDWRVDYILSSSELQEVNEPLVQLR 134

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 2215954558 204 LVVR--KGNSTENVFMELTLPQFYNFLHEMERAKASME 239
Cdd:cd04752   135 LKVRnaDTGEITPHPFSVSADKFRVLLAELKQAQTLME 172
Commd6 cd04754
COMM_Domain containing protein 6. The COMM Domain is found at the C-terminus of a variety of ...
 154-239 4.15e-08

COMM_Domain containing protein 6. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


Pssm-ID: 240102  Cd Length: 86  Bit Score: 49.54  E-value: 4.15e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2215954558 154 QWGEHYAALSRlAVGQTLMVNQLVDMEWKFGVTVGTSEIQKVGNIF--LQLKLVVRKGNSTENVFmELTLPQFYNFLHEM 231
Cdd:cd04754     1 DQQGKLLTASD-SVDQVLNIGQLVDFKWKLGMAVSSDTCRSLNSPYvaVTLKVADPSGQVVTKSF-EMTIPEFQNFSRQF 78


                  ....*...
gi 2215954558 232 ERAKASME 239
Cdd:cd04754    79 KEMAAVLE 86
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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