NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|2215954587|ref|XP_047236236|]
View 

zinc finger protein 260-like [Girardinichthys multiradiatus]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
369-647 6.85e-09

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 58.55  E-value: 6.85e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2215954587 369 KCFTCDDCGKTFHWKNHLSRHMRIHTGEKPFSCEVCGQRFNQNSNLNK--HMRIHTGGKPF-GCDVCGQRFNLKSYLHIH 445
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELsrHLRTHHNNPSDlNSKSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2215954587 446 MRIHTGEKPFGCDVCGQRFNQKSNL------------NKHAKIHTGGKPFSCDFC------GQRFNLKSYLNKHVRVH-- 505
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQlpdllsisnlrnNPLPGNNSSSVNTPQSNSlhpplpANSLSKDPSSNLSLLISsn 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2215954587 506 --TGEKPFRCDVCEQRFNLKSHLNLHKIIHSGEKPFACDVCGQRLMQKSALKKHMKIHSEIKSFDCDVCGRRFNQKSALK 583
Cdd:COG5048   192 vsTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQ 271

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2215954587 584 RHLRIHTG-------DKPFGCDVCGQKFNQKAHLNKHM--TIHTG--AKPFGCDV--CGLGFNLKSHLMRHTKIHTD 647
Cdd:COG5048   272 SSSPNESDsssekgfSLPIKSKQCNISFSRSSPLTRHLrsVNHSGesLKPFSCPYslCGKLFSRNDALKRHILLHTS 348
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
369-647 6.85e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 58.55  E-value: 6.85e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2215954587 369 KCFTCDDCGKTFHWKNHLSRHMRIHTGEKPFSCEVCGQRFNQNSNLNK--HMRIHTGGKPF-GCDVCGQRFNLKSYLHIH 445
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELsrHLRTHHNNPSDlNSKSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2215954587 446 MRIHTGEKPFGCDVCGQRFNQKSNL------------NKHAKIHTGGKPFSCDFC------GQRFNLKSYLNKHVRVH-- 505
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQlpdllsisnlrnNPLPGNNSSSVNTPQSNSlhpplpANSLSKDPSSNLSLLISsn 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2215954587 506 --TGEKPFRCDVCEQRFNLKSHLNLHKIIHSGEKPFACDVCGQRLMQKSALKKHMKIHSEIKSFDCDVCGRRFNQKSALK 583
Cdd:COG5048   192 vsTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQ 271

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2215954587 584 RHLRIHTG-------DKPFGCDVCGQKFNQKAHLNKHM--TIHTG--AKPFGCDV--CGLGFNLKSHLMRHTKIHTD 647
Cdd:COG5048   272 SSSPNESDsssekgfSLPIKSKQCNISFSRSSPLTRHLrsVNHSGesLKPFSCPYslCGKLFSRNDALKRHILLHTS 348
zf-H2C2_2 pfam13465
Zinc-finger double domain;
385-410 1.12e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 42.36  E-value: 1.12e-05
                          10        20
                  ....*....|....*....|....*.
gi 2215954587 385 HLSRHMRIHTGEKPFSCEVCGQRFNQ 410
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
369-647 6.85e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 58.55  E-value: 6.85e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2215954587 369 KCFTCDDCGKTFHWKNHLSRHMRIHTGEKPFSCEVCGQRFNQNSNLNK--HMRIHTGGKPF-GCDVCGQRFNLKSYLHIH 445
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELsrHLRTHHNNPSDlNSKSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2215954587 446 MRIHTGEKPFGCDVCGQRFNQKSNL------------NKHAKIHTGGKPFSCDFC------GQRFNLKSYLNKHVRVH-- 505
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQlpdllsisnlrnNPLPGNNSSSVNTPQSNSlhpplpANSLSKDPSSNLSLLISsn 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2215954587 506 --TGEKPFRCDVCEQRFNLKSHLNLHKIIHSGEKPFACDVCGQRLMQKSALKKHMKIHSEIKSFDCDVCGRRFNQKSALK 583
Cdd:COG5048   192 vsTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQ 271

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2215954587 584 RHLRIHTG-------DKPFGCDVCGQKFNQKAHLNKHM--TIHTG--AKPFGCDV--CGLGFNLKSHLMRHTKIHTD 647
Cdd:COG5048   272 SSSPNESDsssekgfSLPIKSKQCNISFSRSSPLTRHLrsVNHSGesLKPFSCPYslCGKLFSRNDALKRHILLHTS 348
zf-H2C2_2 pfam13465
Zinc-finger double domain;
385-410 1.12e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 42.36  E-value: 1.12e-05
                          10        20
                  ....*....|....*....|....*.
gi 2215954587 385 HLSRHMRIHTGEKPFSCEVCGQRFNQ 410
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
369-613 3.44e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.53  E-value: 3.44e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2215954587 369 KCFTCDDCGKTFHWKNHLSRHMRIHTG-EKPFSCEVCGQRFNQNSNLNKHMR--IHTG--GKPFGCDV--CGQRFNLKSY 441
Cdd:COG5048   259 ESPRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGesLKPFSCPYslCGKLFSRNDA 338

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2215954587 442 LHIHMRIHTGEKPFGC--DVCGQRFNQKSNLNKHAKIHtggkpfscdfcgqrfnlKSYLNKHVRVHTGEKPFRCDVCEQR 519
Cdd:COG5048   339 LKRHILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLQ-----------------QYKDLKNDKKSETLSNSCIRNFKRD 401

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2215954587 520 FNLKSHLNLHKIihsgekpfacdvcgqrlmqksalkkhmkihSEIKSFDCDVCGRRFNQKSALKRHLRIHTGDKPFGCDV 599
Cdd:COG5048   402 SNLSLHIITHLS------------------------------FRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSI 451

                         250
                  ....*....|....
gi 2215954587 600 CGqKFNQKAHLNKH 613
Cdd:COG5048   452 LK-SFRRDLDLSNH 464
zf-H2C2_2 pfam13465
Zinc-finger double domain;
497-521 4.13e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 4.13e-04
                          10        20
                  ....*....|....*....|....*
gi 2215954587 497 YLNKHVRVHTGEKPFRCDVCEQRFN 521
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
581-606 5.44e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 5.44e-04
                          10        20
                  ....*....|....*....|....*.
gi 2215954587 581 ALKRHLRIHTGDKPFGCDVCGQKFNQ 606
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 399-421 5.75e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 37.28  E-value: 5.75e-04
                          10        20
                  ....*....|....*....|...
gi 2215954587 399 FSCEVCGQRFNQNSNLNKHMRIH 421
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 567-589 1.87e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.12  E-value: 1.87e-03
                          10        20
                  ....*....|....*....|...
gi 2215954587 567 FDCDVCGRRFNQKSALKRHLRIH 589
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
413-437 1.93e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.93e-03
                          10        20
                  ....*....|....*....|....*
gi 2215954587 413 NLNKHMRIHTGGKPFGCDVCGQRFN 437
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
445-466 3.25e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 3.25e-03
                          10        20
                  ....*....|....*....|..
gi 2215954587 445 HMRIHTGEKPFGCDVCGQRFNQ 466
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 507-592 6.49e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 39.32  E-value: 6.49e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2215954587 507 GEKPFRCDV--CEQRFNLKSHLNLHKIihSGEkpfacdvCGQRLMQKSALKKHMKIHSEIKSFDCDVCGRRFNQKSALKR 584
Cdd:COG5189   346 DGKPYKCPVegCNKKYKNQNGLKYHML--HGH-------QNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ....*...
gi 2215954587 585 HlRIHTGD 592
Cdd:COG5189   417 H-RKHSHD 423
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH