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Conserved domains on  [gi|2217351347|ref|XP_047271885|]
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mastermind-like protein 3 isoform X1 [Homo sapiens]

Protein Classification

MamL-1 domain-containing protein( domain architecture ID 10560254)

MamL-1 domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
MamL-1 pfam09596
MamL-1 domain; The MamL-1 domain is a polypeptide of up to 70 residues, numbers 15-67 of which ...
68-125 4.67e-22

MamL-1 domain; The MamL-1 domain is a polypeptide of up to 70 residues, numbers 15-67 of which adopt an elongated kinked helix that wraps around ANK and CSL forming one of the complexes in the build-up of the Notch transcriptional complex for recruiting general transcription factors..


:

Pssm-ID: 462834  Cd Length: 58  Bit Score: 90.45  E-value: 4.67e-22
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 2217351347   68 PKHSTVVERLRQRIEGCRRHHVNCENRYQQAQVEQLELERRDTVSLYQRTLEQRAKKS 125
Cdd:pfam09596    1 PKHQAVVDRLRRRIELYRRHHNDCESRYDNTQAERCEQERQETLMLHQRVLDSKAKRT 58
PRK12323 super family cl46901
DNA polymerase III subunit gamma/tau;
372-466 5.47e-04

DNA polymerase III subunit gamma/tau;


The actual alignment was detected with superfamily member PRK12323:

Pssm-ID: 481241 [Multi-domain]  Cd Length: 700  Bit Score: 44.10  E-value: 5.47e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217351347  372 GSPQARPSSSGPPFSTVSTATSLPSVAsTPAAPNPASSPANCAVQSPQTPNQAHTPGQAPPRPGNGYLLNPAAVTVAGSA 451
Cdd:PRK12323   369 GGGAGPATAAAAPVAQPAPAAAAPAAA-APAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGPGGA 447
                           90
                   ....*....|....*
gi 2217351347  452 SGPVAVPSSDMSPAE 466
Cdd:PRK12323   448 PAPAPAPAAAPAAAA 462
 
Name Accession Description Interval E-value
MamL-1 pfam09596
MamL-1 domain; The MamL-1 domain is a polypeptide of up to 70 residues, numbers 15-67 of which ...
68-125 4.67e-22

MamL-1 domain; The MamL-1 domain is a polypeptide of up to 70 residues, numbers 15-67 of which adopt an elongated kinked helix that wraps around ANK and CSL forming one of the complexes in the build-up of the Notch transcriptional complex for recruiting general transcription factors..


Pssm-ID: 462834  Cd Length: 58  Bit Score: 90.45  E-value: 4.67e-22
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 2217351347   68 PKHSTVVERLRQRIEGCRRHHVNCENRYQQAQVEQLELERRDTVSLYQRTLEQRAKKS 125
Cdd:pfam09596    1 PKHQAVVDRLRRRIELYRRHHNDCESRYDNTQAERCEQERQETLMLHQRVLDSKAKRT 58
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
372-466 5.47e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 44.10  E-value: 5.47e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217351347  372 GSPQARPSSSGPPFSTVSTATSLPSVAsTPAAPNPASSPANCAVQSPQTPNQAHTPGQAPPRPGNGYLLNPAAVTVAGSA 451
Cdd:PRK12323   369 GGGAGPATAAAAPVAQPAPAAAAPAAA-APAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGPGGA 447
                           90
                   ....*....|....*
gi 2217351347  452 SGPVAVPSSDMSPAE 466
Cdd:PRK12323   448 PAPAPAPAAAPAAAA 462
 
Name Accession Description Interval E-value
MamL-1 pfam09596
MamL-1 domain; The MamL-1 domain is a polypeptide of up to 70 residues, numbers 15-67 of which ...
68-125 4.67e-22

MamL-1 domain; The MamL-1 domain is a polypeptide of up to 70 residues, numbers 15-67 of which adopt an elongated kinked helix that wraps around ANK and CSL forming one of the complexes in the build-up of the Notch transcriptional complex for recruiting general transcription factors..


Pssm-ID: 462834  Cd Length: 58  Bit Score: 90.45  E-value: 4.67e-22
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 2217351347   68 PKHSTVVERLRQRIEGCRRHHVNCENRYQQAQVEQLELERRDTVSLYQRTLEQRAKKS 125
Cdd:pfam09596    1 PKHQAVVDRLRRRIELYRRHHNDCESRYDNTQAERCEQERQETLMLHQRVLDSKAKRT 58
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
372-466 5.47e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 44.10  E-value: 5.47e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217351347  372 GSPQARPSSSGPPFSTVSTATSLPSVAsTPAAPNPASSPANCAVQSPQTPNQAHTPGQAPPRPGNGYLLNPAAVTVAGSA 451
Cdd:PRK12323   369 GGGAGPATAAAAPVAQPAPAAAAPAAA-APAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGPGGA 447
                           90
                   ....*....|....*
gi 2217351347  452 SGPVAVPSSDMSPAE 466
Cdd:PRK12323   448 PAPAPAPAAAPAAAA 462
PRK13042 PRK13042
superantigen-like protein SSL4; Reviewed;
346-433 1.19e-03

superantigen-like protein SSL4; Reviewed;


Pssm-ID: 183854 [Multi-domain]  Cd Length: 291  Bit Score: 42.31  E-value: 1.19e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217351347  346 TETPLSQESASVKSDPSHSPFAHVSMGSPQARPSSSGPPFSTVSTATSLPSvastpaapnpASSPANCAVQSPQTPNQAH 425
Cdd:PRK13042    25 TQAANATTPSSTKVEAPQSTPPSTKVEAPQSKPNATTPPSTKVEAPQQTPN----------ATTPSSTKVETPQSPTTKQ 94

                   ....*...
gi 2217351347  426 TPGQAPPR 433
Cdd:PRK13042    95 VPTEINPK 102
PHA03247 PHA03247
large tegument protein UL36; Provisional
339-466 3.92e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.46  E-value: 3.92e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217351347  339 PEFSQPATETPLSQESASVKSD-------PSHSPFAHVSMGSPQARPSSSGPPFSTVSTATSLPSVASTPAAPNPASSPA 411
Cdd:PHA03247  2712 PHALVSATPLPPGPAAARQASPalpaapaPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASL 2791
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2217351347  412 NCAVQSPQTPNQAHTPGQAPPRPGNGylLNPAAVTVAGSASGPVAVPSSDMSPAE 466
Cdd:PHA03247  2792 SESRESLPSPWDPADPPAAVLAPAAA--LPPAASPAGPLPPPTSAQPTAPPPPPG 2844
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
355-466 5.05e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 41.12  E-value: 5.05e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217351347  355 ASVKSDPSHSPFAHVSmGSPQARPSSSGPPFSTVSTATSLPSVASTPAAPNPASSPANCAVQSPQTPNQAHTPGQAPPRP 434
Cdd:PRK07764   390 GAGAPAAAAPSAAAAA-PAAAPAPAAAAPAAAAAPAPAAAPQPAPAPAPAPAPPSPAGNAPAGGAPSPPPAAAPSAQPAP 468
                           90       100       110
                   ....*....|....*....|....*....|..
gi 2217351347  435 GNGyllnPAAVTVAGSASGPVAVPSSDMSPAE 466
Cdd:PRK07764   469 APA----AAPEPTAAPAPAPPAAPAPAAAPAA 496
PRK06975 PRK06975
bifunctional uroporphyrinogen-III synthetase/uroporphyrin-III C-methyltransferase; Reviewed
367-453 5.43e-03

bifunctional uroporphyrinogen-III synthetase/uroporphyrin-III C-methyltransferase; Reviewed


Pssm-ID: 235899 [Multi-domain]  Cd Length: 656  Bit Score: 40.86  E-value: 5.43e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217351347  367 AHVSMGSPQARPSSSGPPFSTVSTATSLPSVASTPAAPNPASSPAncavqspqtPNQAHTPGQAPPRPGNGYLLNPAAVT 446
Cdd:PRK06975   261 AFLTWADAAAQPATAAPAPSRMTDTNDSKSVTSQPAAAAAAPAPP---------PNPPATPPEPPARRGRGSAALWFVVV 331

                   ....*..
gi 2217351347  447 VAGSASG 453
Cdd:PRK06975   332 VLACAAA 338
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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