|
Name |
Accession |
Description |
Interval |
E-value |
| DEXHc_DDX60 |
cd18025 |
DEXH-box helicase domain of DEAD box protein 60; DEAD box protein 60 (DDX60) is an ... |
743-926 |
2.71e-101 |
|
DEXH-box helicase domain of DEAD box protein 60; DEAD box protein 60 (DDX60) is an IFN-inducible cytoplasmic helicase that plays a role in RIG-I-mediated type I interferon (IFN) nuclease-mediated viral RNA degradation. DDX60 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350783 [Multi-domain] Cd Length: 192 Bit Score: 322.40 E-value: 2.71e-101
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217352639 743 IPNAWQQELLDVVDKNESAVIVAPTSSGKTYASYYCMEKVLRESDVGVVVYVAPAKSLVGQVAATVENRFTKTL-PAGRT 821
Cdd:cd18025 1 NPDAWQRELLDIVDRRESALIVAPTSSGKTFISYYCMEKVLRESDDGVVVYVAPTKALVNQVVAEVYARFSKKYpPSGKS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217352639 822 LCGAFTRDYCHN-VLNCQVLITVPECFEILLLAPHRQKWVERIRYVIFDEVHYLGREVGAKFWELLLVIIRCPFLVLSAT 900
Cdd:cd18025 81 LWGVFTRDYRHNnPMNCQVLITVPECLEILLLSPHNASWVPRIKYVIFDEIHSIGQSEDGAVWEQLLLLIPCPFLALSAT 160
|
170 180
....*....|....*....|....*.
gi 2217352639 901 INNPNLLTKWLQSVKQYWKQADKIME 926
Cdd:cd18025 161 IGNPQKFHEWLQSVQRARKAELKKIE 186
|
|
| SF2_C_Ski2 |
cd18795 |
C-terminal helicase domain of the Ski2 family helicases; Ski2-like RNA helicases play an ... |
1220-1273 |
3.52e-18 |
|
C-terminal helicase domain of the Ski2 family helicases; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. This family includes spliceosomal Brr2 RNA helicase, ASCC3 (involved in the repair of N-alkylated nucleotides), Mtr4 (involved in processing of structured RNAs), DDX60 (involved in viral RNA degradation), and other proteins. Ski2-like RNA helicases are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350182 [Multi-domain] Cd Length: 154 Bit Score: 82.99 E-value: 3.52e-18
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2217352639 1220 VVTATETLALGIHMPCKSVVFAQDSVY-------LDALNYRQMSGRAGRRGQDLLGNVYFF 1273
Cdd:cd18795 92 VLVATSTLAAGVNLPARTVIIKGTQRYdgkgyreLSPLEYLQMIGRAGRPGFDTRGEAIIM 152
|
|
| BRR2 |
COG1204 |
Replicative superfamily II helicase [Replication, recombination and repair]; |
748-911 |
4.34e-18 |
|
Replicative superfamily II helicase [Replication, recombination and repair];
Pssm-ID: 440817 [Multi-domain] Cd Length: 529 Bit Score: 89.95 E-value: 4.34e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217352639 748 QQELLD-VVDKNESAVIVAPTSSGKTYASYYCMEKVLRESdvGVVVYVAPAKSLVGQVaatvENRFTKTLPAGRTLCGAF 826
Cdd:COG1204 27 QAEALEaGLLEGKNLVVSAPTASGKTLIAELAILKALLNG--GKALYIVPLRALASEK----YREFKRDFEELGIKVGVS 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217352639 827 TRDYCHN---VLNCQVLITVPECFEILLLapHRQKWVERIRYVIFDEVHYLG-REVGAKFwELLLVIIR--CP---FLVL 897
Cdd:COG1204 101 TGDYDSDdewLGRYDILVATPEKLDSLLR--NGPSWLRDVDLVVVDEAHLIDdESRGPTL-EVLLARLRrlNPeaqIVAL 177
|
170
....*....|....
gi 2217352639 898 SATINNPNLLTKWL 911
Cdd:COG1204 178 SATIGNAEEIAEWL 191
|
|
| Dob10 |
COG4581 |
Superfamily II RNA helicase [Replication, recombination and repair]; |
748-1338 |
4.57e-17 |
|
Superfamily II RNA helicase [Replication, recombination and repair];
Pssm-ID: 443638 [Multi-domain] Cd Length: 751 Bit Score: 87.30 E-value: 4.57e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217352639 748 QQELLDVVDKNESAVIVAPTSSGKTYASYYCMEKVLRESdvGVVVYVAPAKSLVGQvaatvenRFtktlpagRTLCGAFT 827
Cdd:COG4581 30 QEEAILALEAGRSVLVAAPTGSGKTLVAEFAIFLALARG--RRSFYTAPIKALSNQ-------KF-------FDLVERFG 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217352639 828 RDychNV--------LNCQVLITVpeC-FEIL---LLAPHRQkwVERIRYVIFDEVHYLG-REVGAkFWELllVIIRCP- 893
Cdd:COG4581 94 AE---NVglltgdasVNPDAPIVV--MtTEILrnmLYREGAD--LEDVGVVVMDEFHYLAdPDRGW-VWEE--PIIHLPa 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217352639 894 ---FLVLSATINNPNLLTKWLQSVKQywkqadkimeekcisekqadkclnflqdhsyknqsyEVRLVLCGERYNDLEKHI 970
Cdd:COG4581 164 rvqLVLLSATVGNAEEFAEWLTRVRG------------------------------------ETAVVVSEERPVPLEFHY 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217352639 971 CsvkhddvyfdhfhpcaaLTTDIIEKYGFPPDLTLTPQesiqlydtmaqVWETwpraqelcpeefilfknkivikkldar 1050
Cdd:COG4581 208 L-----------------VTPRLFPLFRVNPELLRPPS-----------RHEV--------------------------- 232
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217352639 1051 kyeenlkaeltnwikngqvkkvkrvlknlspdslssskdmvkmfpllVEKLRQMDKLPAIFFLFKNDDVGKRA-----GS 1125
Cdd:COG4581 233 -----------------------------------------------IEELDRGGLLPAIVFIFSRRGCDEAAqqllsAR 265
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217352639 1126 VCTFLEKtetkshphtechsyvfaiDEVLEKVRKTQKRITKKNPKKAEKLERKKV----------YRaeyinflenlkil 1195
Cdd:COG4581 266 LTTKEER------------------AEIREAIDEFAEDFSVLFGKTLSRLLRRGIavhhagmlpkYR------------- 314
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217352639 1196 EISEDCtyadvkALHTEITrnkdsVVTATETLALGIHMPCKSVVFAQDS-------VYLDALNYRQMSGRAGRRGQDLLG 1268
Cdd:COG4581 315 RLVEEL------FQAGLLK-----VVFATDTLAVGINMPARTVVFTKLSkfdgerhRPLTAREFHQIAGRAGRRGIDTEG 383
|
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2217352639 1269 NVY-----FFDiplPKIKRLLASSVPE-LRGQFPLSITLVLRlmLLASKGddPEDAKAkvlsVLKHSLLSFKRRRA 1338
Cdd:COG4581 384 HVVvlapeHDD---PKKFARLASARPEpLRSSFRPSYNMVLN--LLARPG--LERARE----LLEDSFAQFQADRS 448
|
|
| DEAD |
pfam00270 |
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ... |
748-902 |
8.13e-17 |
|
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.
Pssm-ID: 425570 [Multi-domain] Cd Length: 165 Bit Score: 79.59 E-value: 8.13e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217352639 748 QQELLDVVDKNESAVIVAPTSSGKTYASYYCMEKVLRESDVGV-VVYVAPAKSLVGQVAATVENRFTKTLPAGRTLCGAF 826
Cdd:pfam00270 4 QAEAIPAILEGRDVLVQAPTGSGKTLAFLLPALEALDKLDNGPqALVLAPTRELAEQIYEELKKLGKGLGLKVASLLGGD 83
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2217352639 827 TRDYCHNVL-NCQVLITVPECFEILLlapHRQKWVERIRYVIFDEVHYLGREVGAKFWELLLVIIR--CPFLVLSATIN 902
Cdd:pfam00270 84 SRKEQLEKLkGPDILVGTPGRLLDLL---QERKLLKNLKLLVLDEAHRLLDMGFGPDLEEILRRLPkkRQILLLSATLP 159
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
742-911 |
3.11e-16 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 79.07 E-value: 3.11e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217352639 742 FIPNAWQQELLD-VVDKNESAVIVAPTSSGKTYASYYCMEKVLRESDVGVVVYVAPAKSLVGQVAATVENRFTKTlpaGR 820
Cdd:smart00487 7 EPLRPYQKEAIEaLLSGLRDVILAAPTGSGKTLAALLPALEALKRGKGGRVLVLVPTRELAEQWAEELKKLGPSL---GL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217352639 821 TLCGAFTRDYCHNVL------NCQVLITVPECFEILLLapHRQKWVERIRYVIFDEVHYLGrevGAKFWELLLVIIR--- 891
Cdd:smart00487 84 KVVGLYGGDSKREQLrklesgKTDILVTTPGRLLDLLE--NDKLSLSNVDLVILDEAHRLL---DGGFGDQLEKLLKllp 158
|
170 180
....*....|....*....|..
gi 2217352639 892 --CPFLVLSATINNPNLLTKWL 911
Cdd:smart00487 159 knVQLLLLSATPPEEIENLLEL 180
|
|
| PRK00254 |
PRK00254 |
ski2-like helicase; Provisional |
757-919 |
1.91e-09 |
|
ski2-like helicase; Provisional
Pssm-ID: 234702 [Multi-domain] Cd Length: 720 Bit Score: 62.53 E-value: 1.91e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217352639 757 KNESAVIVAPTSSGKTYASYYCM-EKVLRESdvGVVVYVAPAKSLVGQ--------------VAATVENRFTKTLPAGRT 821
Cdd:PRK00254 38 EGKNLVLAIPTASGKTLVAEIVMvNKLLREG--GKAVYLVPLKALAEEkyrefkdweklglrVAMTTGDYDSTDEWLGKY 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217352639 822 lcgaftrdychnvlncQVLITVPECFEILLlaPHRQKWVERIRYVIFDEVHYLG-REVGAKFwELLL--VIIRCPFLVLS 898
Cdd:PRK00254 116 ----------------DIIIATAEKFDSLL--RHGSSWIKDVKLVVADEIHLIGsYDRGATL-EMILthMLGRAQILGLS 176
|
170 180
....*....|....*....|...
gi 2217352639 899 ATINNPNLLTKWLQS--VKQYWK 919
Cdd:PRK00254 177 ATVGNAEELAEWLNAelVVSDWR 199
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
1191-1263 |
7.28e-06 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 45.67 E-value: 7.28e-06
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2217352639 1191 NLKILEISEDCTYADVKALHTEITRNKDSVVTATETLALGIHMPCKSVVFaQDSVYLDALNYRQMSGRAGRRG 1263
Cdd:smart00490 11 GIKVARLHGGLSQEEREEILDKFNNGKIKVLVATDVAERGLDLPGVDLVI-IYDLPWSPASYIQRIGRAGRAG 82
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
1183-1263 |
5.65e-04 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 41.04 E-value: 5.65e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217352639 1183 AEYINFLENLKILEISEDCTYADVKALHTEITRNKDSVVTATETLALGIHMPCKSVVFAQDSVYlDALNYRQMSGRAGRR 1262
Cdd:pfam00271 30 AELLLEKEGIKVARLHGDLSQEEREEILEDFRKGKIDVLVATDVAERGLDLPDVDLVINYDLPW-NPASYIQRIGRAGRA 108
|
.
gi 2217352639 1263 G 1263
Cdd:pfam00271 109 G 109
|
|
| PRK02362 |
PRK02362 |
ATP-dependent DNA helicase; |
1220-1265 |
1.56e-03 |
|
ATP-dependent DNA helicase;
Pssm-ID: 235032 [Multi-domain] Cd Length: 737 Bit Score: 43.41 E-value: 1.56e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 2217352639 1220 VVTATETLALGIHMPCKSVV------FAQDS--VYLDALNYRQMSGRAGRRGQD 1265
Cdd:PRK02362 332 VISSTPTLAAGLNLPARRVIirdyrrYDGGAgmQPIPVLEYHQMAGRAGRPGLD 385
|
|
|
|
Name |
Accession |
Description |
Interval |
E-value |
| DEXHc_DDX60 |
cd18025 |
DEXH-box helicase domain of DEAD box protein 60; DEAD box protein 60 (DDX60) is an ... |
743-926 |
2.71e-101 |
|
DEXH-box helicase domain of DEAD box protein 60; DEAD box protein 60 (DDX60) is an IFN-inducible cytoplasmic helicase that plays a role in RIG-I-mediated type I interferon (IFN) nuclease-mediated viral RNA degradation. DDX60 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350783 [Multi-domain] Cd Length: 192 Bit Score: 322.40 E-value: 2.71e-101
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217352639 743 IPNAWQQELLDVVDKNESAVIVAPTSSGKTYASYYCMEKVLRESDVGVVVYVAPAKSLVGQVAATVENRFTKTL-PAGRT 821
Cdd:cd18025 1 NPDAWQRELLDIVDRRESALIVAPTSSGKTFISYYCMEKVLRESDDGVVVYVAPTKALVNQVVAEVYARFSKKYpPSGKS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217352639 822 LCGAFTRDYCHN-VLNCQVLITVPECFEILLLAPHRQKWVERIRYVIFDEVHYLGREVGAKFWELLLVIIRCPFLVLSAT 900
Cdd:cd18025 81 LWGVFTRDYRHNnPMNCQVLITVPECLEILLLSPHNASWVPRIKYVIFDEIHSIGQSEDGAVWEQLLLLIPCPFLALSAT 160
|
170 180
....*....|....*....|....*.
gi 2217352639 901 INNPNLLTKWLQSVKQYWKQADKIME 926
Cdd:cd18025 161 IGNPQKFHEWLQSVQRARKAELKKIE 186
|
|
| DEXHc_Ski2 |
cd17921 |
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases ... |
745-914 |
1.17e-40 |
|
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350679 [Multi-domain] Cd Length: 181 Bit Score: 148.56 E-value: 1.17e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217352639 745 NAWQQELLD-VVDKNESAVIVAPTSSGKTYASYYCMEKVLRESDvGVVVYVAPAKSLVGQVAAtvenRFTKTLPAGRTLC 823
Cdd:cd17921 3 NPIQREALRaLYLSGDSVLVSAPTSSGKTLIAELAILRALATSG-GKAVYIAPTRALVNQKEA----DLRERFGPLGKNV 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217352639 824 GAFTRDYCHN---VLNCQVLITVPECFEILLLAPHrQKWVERIRYVIFDEVHYLGREVGAKFWELLLVIIR-----CPFL 895
Cdd:cd17921 78 GLLTGDPSVNkllLAEADILVATPEKLDLLLRNGG-ERLIQDVRLVVVDEAHLIGDGERGVVLELLLSRLLrinknARFV 156
|
170
....*....|....*....
gi 2217352639 896 VLSATINNPNLLTKWLQSV 914
Cdd:cd17921 157 GLSATLPNAEDLAEWLGVE 175
|
|
| SF2_C_Ski2 |
cd18795 |
C-terminal helicase domain of the Ski2 family helicases; Ski2-like RNA helicases play an ... |
1220-1273 |
3.52e-18 |
|
C-terminal helicase domain of the Ski2 family helicases; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. This family includes spliceosomal Brr2 RNA helicase, ASCC3 (involved in the repair of N-alkylated nucleotides), Mtr4 (involved in processing of structured RNAs), DDX60 (involved in viral RNA degradation), and other proteins. Ski2-like RNA helicases are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350182 [Multi-domain] Cd Length: 154 Bit Score: 82.99 E-value: 3.52e-18
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2217352639 1220 VVTATETLALGIHMPCKSVVFAQDSVY-------LDALNYRQMSGRAGRRGQDLLGNVYFF 1273
Cdd:cd18795 92 VLVATSTLAAGVNLPARTVIIKGTQRYdgkgyreLSPLEYLQMIGRAGRPGFDTRGEAIIM 152
|
|
| BRR2 |
COG1204 |
Replicative superfamily II helicase [Replication, recombination and repair]; |
748-911 |
4.34e-18 |
|
Replicative superfamily II helicase [Replication, recombination and repair];
Pssm-ID: 440817 [Multi-domain] Cd Length: 529 Bit Score: 89.95 E-value: 4.34e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217352639 748 QQELLD-VVDKNESAVIVAPTSSGKTYASYYCMEKVLRESdvGVVVYVAPAKSLVGQVaatvENRFTKTLPAGRTLCGAF 826
Cdd:COG1204 27 QAEALEaGLLEGKNLVVSAPTASGKTLIAELAILKALLNG--GKALYIVPLRALASEK----YREFKRDFEELGIKVGVS 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217352639 827 TRDYCHN---VLNCQVLITVPECFEILLLapHRQKWVERIRYVIFDEVHYLG-REVGAKFwELLLVIIR--CP---FLVL 897
Cdd:COG1204 101 TGDYDSDdewLGRYDILVATPEKLDSLLR--NGPSWLRDVDLVVVDEAHLIDdESRGPTL-EVLLARLRrlNPeaqIVAL 177
|
170
....*....|....
gi 2217352639 898 SATINNPNLLTKWL 911
Cdd:COG1204 178 SATIGNAEEIAEWL 191
|
|
| Dob10 |
COG4581 |
Superfamily II RNA helicase [Replication, recombination and repair]; |
748-1338 |
4.57e-17 |
|
Superfamily II RNA helicase [Replication, recombination and repair];
Pssm-ID: 443638 [Multi-domain] Cd Length: 751 Bit Score: 87.30 E-value: 4.57e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217352639 748 QQELLDVVDKNESAVIVAPTSSGKTYASYYCMEKVLRESdvGVVVYVAPAKSLVGQvaatvenRFtktlpagRTLCGAFT 827
Cdd:COG4581 30 QEEAILALEAGRSVLVAAPTGSGKTLVAEFAIFLALARG--RRSFYTAPIKALSNQ-------KF-------FDLVERFG 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217352639 828 RDychNV--------LNCQVLITVpeC-FEIL---LLAPHRQkwVERIRYVIFDEVHYLG-REVGAkFWELllVIIRCP- 893
Cdd:COG4581 94 AE---NVglltgdasVNPDAPIVV--MtTEILrnmLYREGAD--LEDVGVVVMDEFHYLAdPDRGW-VWEE--PIIHLPa 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217352639 894 ---FLVLSATINNPNLLTKWLQSVKQywkqadkimeekcisekqadkclnflqdhsyknqsyEVRLVLCGERYNDLEKHI 970
Cdd:COG4581 164 rvqLVLLSATVGNAEEFAEWLTRVRG------------------------------------ETAVVVSEERPVPLEFHY 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217352639 971 CsvkhddvyfdhfhpcaaLTTDIIEKYGFPPDLTLTPQesiqlydtmaqVWETwpraqelcpeefilfknkivikkldar 1050
Cdd:COG4581 208 L-----------------VTPRLFPLFRVNPELLRPPS-----------RHEV--------------------------- 232
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217352639 1051 kyeenlkaeltnwikngqvkkvkrvlknlspdslssskdmvkmfpllVEKLRQMDKLPAIFFLFKNDDVGKRA-----GS 1125
Cdd:COG4581 233 -----------------------------------------------IEELDRGGLLPAIVFIFSRRGCDEAAqqllsAR 265
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217352639 1126 VCTFLEKtetkshphtechsyvfaiDEVLEKVRKTQKRITKKNPKKAEKLERKKV----------YRaeyinflenlkil 1195
Cdd:COG4581 266 LTTKEER------------------AEIREAIDEFAEDFSVLFGKTLSRLLRRGIavhhagmlpkYR------------- 314
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217352639 1196 EISEDCtyadvkALHTEITrnkdsVVTATETLALGIHMPCKSVVFAQDS-------VYLDALNYRQMSGRAGRRGQDLLG 1268
Cdd:COG4581 315 RLVEEL------FQAGLLK-----VVFATDTLAVGINMPARTVVFTKLSkfdgerhRPLTAREFHQIAGRAGRRGIDTEG 383
|
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2217352639 1269 NVY-----FFDiplPKIKRLLASSVPE-LRGQFPLSITLVLRlmLLASKGddPEDAKAkvlsVLKHSLLSFKRRRA 1338
Cdd:COG4581 384 HVVvlapeHDD---PKKFARLASARPEpLRSSFRPSYNMVLN--LLARPG--LERARE----LLEDSFAQFQADRS 448
|
|
| DEAD |
pfam00270 |
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ... |
748-902 |
8.13e-17 |
|
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.
Pssm-ID: 425570 [Multi-domain] Cd Length: 165 Bit Score: 79.59 E-value: 8.13e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217352639 748 QQELLDVVDKNESAVIVAPTSSGKTYASYYCMEKVLRESDVGV-VVYVAPAKSLVGQVAATVENRFTKTLPAGRTLCGAF 826
Cdd:pfam00270 4 QAEAIPAILEGRDVLVQAPTGSGKTLAFLLPALEALDKLDNGPqALVLAPTRELAEQIYEELKKLGKGLGLKVASLLGGD 83
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2217352639 827 TRDYCHNVL-NCQVLITVPECFEILLlapHRQKWVERIRYVIFDEVHYLGREVGAKFWELLLVIIR--CPFLVLSATIN 902
Cdd:pfam00270 84 SRKEQLEKLkGPDILVGTPGRLLDLL---QERKLLKNLKLLVLDEAHRLLDMGFGPDLEEILRRLPkkRQILLLSATLP 159
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
742-911 |
3.11e-16 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 79.07 E-value: 3.11e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217352639 742 FIPNAWQQELLD-VVDKNESAVIVAPTSSGKTYASYYCMEKVLRESDVGVVVYVAPAKSLVGQVAATVENRFTKTlpaGR 820
Cdd:smart00487 7 EPLRPYQKEAIEaLLSGLRDVILAAPTGSGKTLAALLPALEALKRGKGGRVLVLVPTRELAEQWAEELKKLGPSL---GL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217352639 821 TLCGAFTRDYCHNVL------NCQVLITVPECFEILLLapHRQKWVERIRYVIFDEVHYLGrevGAKFWELLLVIIR--- 891
Cdd:smart00487 84 KVVGLYGGDSKREQLrklesgKTDILVTTPGRLLDLLE--NDKLSLSNVDLVILDEAHRLL---DGGFGDQLEKLLKllp 158
|
170 180
....*....|....*....|..
gi 2217352639 892 --CPFLVLSATINNPNLLTKWL 911
Cdd:smart00487 159 knVQLLLLSATPPEEIENLLEL 180
|
|
| DEXHc_LHR-like |
cd17922 |
DEXH-box helicase domain of LHR; Large helicase-related protein (LHR) is a DNA ... |
758-911 |
1.01e-15 |
|
DEXH-box helicase domain of LHR; Large helicase-related protein (LHR) is a DNA damage-inducible helicase that uses ATP hydrolysis to drive unidirectional 3'-to-5' translocation along single-stranded DNA (ssDNA) and to unwind RNA:DNA duplexes. This group also includes related bacterial and archaeal helicases from the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350680 [Multi-domain] Cd Length: 166 Bit Score: 76.47 E-value: 1.01e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217352639 758 NESAVIVAPTSSGKTYASYYC-MEKVLRESDVGV-VVYVAPAKSLV------------------------GQVAATVENR 811
Cdd:cd17922 1 GRNVLIAAPTGSGKTEAAFLPaLSSLADEPEKGVqVLYISPLKALIndqerrleepldeidleipvavrhGDTSQSEKAK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217352639 812 FTKTLPagrtlcgaftrdychnvlncQVLITVPECFEILLLAPHRQKWVERIRYVIFDEVH-YLGREVGAKFwELLLV-- 888
Cdd:cd17922 81 QLKNPP--------------------GILITTPESLELLLVNKKLRELFAGLRYVVVDEIHaLLGSKRGVQL-ELLLErl 139
|
170 180
....*....|....*....|....*..
gi 2217352639 889 --IIRCPFLV--LSATINNPNLLTKWL 911
Cdd:cd17922 140 rkLTGRPLRRigLSATLGNLEEAAAFL 166
|
|
| SSL2 |
COG1061 |
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair]; |
725-900 |
6.39e-15 |
|
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
Pssm-ID: 440681 [Multi-domain] Cd Length: 566 Bit Score: 80.07 E-value: 6.39e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217352639 725 HYLIRDERKDRDPRVQ-DFIPNAWQQELLD-----VVDKNESAVIVAPTSSGKTYASYYCMEKVLResdVGVVVYVAPAK 798
Cdd:COG1061 61 ELAEAEALEAGDEASGtSFELRPYQQEALEallaaLERGGGRGLVVAPTGTGKTVLALALAAELLR---GKRVLVLVPRR 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217352639 799 SLVGQVAATVENRFTKTLPAGrtlcGAFTRDYCHNVLNCQVLITvpecfeilllAPHRQKWVERIRYVIFDEVHYLgrev 878
Cdd:COG1061 138 ELLEQWAEELRRFLGDPLAGG----GKKDSDAPITVATYQSLAR----------RAHLDELGDRFGLVIIDEAHHA---- 199
|
170 180
....*....|....*....|...
gi 2217352639 879 GAKFWELLLVIIRCPFLV-LSAT 900
Cdd:COG1061 200 GAPSYRRILEAFPAAYRLgLTAT 222
|
|
| DEXHc_HFM1 |
cd18023 |
DEXH-box helicase domain of ATP-dependent DNA helicase HFM1; HFM1 is a type II DEAD box ... |
745-912 |
7.55e-15 |
|
DEXH-box helicase domain of ATP-dependent DNA helicase HFM1; HFM1 is a type II DEAD box helicase, required for crossover formation and complete synapsis of homologous chromosomes during meiosis. HFM1 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350781 [Multi-domain] Cd Length: 206 Bit Score: 75.09 E-value: 7.55e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217352639 745 NAWQQELL-DVVDKNESAVIVAPTSSGKTYASYYCMEKVLRESDVG-----VVVYVAPAKSLVGQVAATVENRFTktlPA 818
Cdd:cd18023 3 NRIQSEVFpDLLYSDKNFVVSAPTGSGKTVLFELAILRLLKERNPLpwgnrKVVYIAPIKALCSEKYDDWKEKFG---PL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217352639 819 GRTlCGAFTRDY----CHNVLNCQVLITVPECFE-ILLLAPHRQKWVERIRYVIFDEVHYLGREVGA------------- 880
Cdd:cd18023 80 GLS-CAELTGDTemddTFEIQDADIILTTPEKWDsMTRRWRDNGNLVQLVALVLIDEVHIIKENRGAtlevvvsrmktls 158
|
170 180 190
....*....|....*....|....*....|...
gi 2217352639 881 KFWELL-LVIIRCPFLVLSATINNPNLLTKWLQ 912
Cdd:cd18023 159 SSSELRgSTVRPMRFVAVSATIPNIEDLAEWLG 191
|
|
| DEXHc_ASCC3_2 |
cd18022 |
C-terminal DEXH-box helicase domain of Activating signal cointegrator 1 complex subunit 3; ... |
758-911 |
1.38e-14 |
|
C-terminal DEXH-box helicase domain of Activating signal cointegrator 1 complex subunit 3; Activating signal cointegrator 1 complex subunit 3 (ASCC3) is a type II DEAD box helicase that plays a role in the repair of N-alkylated nucleotides. ASCC3 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350780 [Multi-domain] Cd Length: 189 Bit Score: 73.95 E-value: 1.38e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217352639 758 NESAVIVAPTSSGKTYASYYCMEKVLRESDVGVVVYVAPAKSLVGQVAATVENRFTKTLpaGRT---LCGAFTRDyCHNV 834
Cdd:cd18022 17 DNNVLLGAPTGSGKTIAAELAMFRAFNKYPGSKVVYIAPLKALVRERVDDWKKRFEEKL--GKKvveLTGDVTPD-MKAL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217352639 835 LNCQVLITVPECFEILLLAPHRQKWVERIRYVIFDEVHYLGREVGAkfweLLLVII-RCPFLV-----------LSATIN 902
Cdd:cd18022 94 ADADIIITTPEKWDGISRSWQTREYVQQVSLIIIDEIHLLGSDRGP----VLEVIVsRMNYISsqtekpvrlvgLSTALA 169
|
....*....
gi 2217352639 903 NPNLLTKWL 911
Cdd:cd18022 170 NAGDLANWL 178
|
|
| DEXHc_Mtr4-like |
cd18024 |
DEXH-box helicase domain of ATP-dependent RNA helicase Mtr4; Mtr4 (also known as DOB1 or ... |
742-916 |
6.83e-13 |
|
DEXH-box helicase domain of ATP-dependent RNA helicase Mtr4; Mtr4 (also known as DOB1 or SKIV2L2) is a type II DEAD box helicase that plays a role in the processing of structured RNAs, including the maturation of 5.8S ribosomal RNA (rRNA)and is part of the TRAMP complex that is involved in exosome-mediated degradation of aberrant RNAs. Mtr4 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350782 [Multi-domain] Cd Length: 205 Bit Score: 69.39 E-value: 6.83e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217352639 742 FIPNAWQQELLDVVDKNESAVIVAPTSSGKTYASYYCMEKVLRESDvgVVVYVAPAKSLVGQVAATVENRFTKTlpagrt 821
Cdd:cd18024 31 FTLDPFQKTAIACIERNESVLVSAHTSAGKTVVAEYAIAQSLRDKQ--RVIYTSPIKALSNQKYRELQEEFGDV------ 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217352639 822 lcGAFTRDYCHN-VLNCQVLITvpecfEILLLAPHRQKWVER-IRYVIFDEVHYL-GREVGAkFWE--LLLVIIRCPFLV 896
Cdd:cd18024 103 --GLMTGDVTINpNASCLVMTT-----EILRSMLYRGSEIMReVAWVIFDEIHYMrDKERGV-VWEetIILLPDKVRYVF 174
|
170 180
....*....|....*....|
gi 2217352639 897 LSATINNPNLLTKWLQSVKQ 916
Cdd:cd18024 175 LSATIPNARQFAEWICKIHK 194
|
|
| ResIII |
pfam04851 |
Type III restriction enzyme, res subunit; |
741-902 |
4.83e-12 |
|
Type III restriction enzyme, res subunit;
Pssm-ID: 398492 [Multi-domain] Cd Length: 162 Bit Score: 65.77 E-value: 4.83e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217352639 741 DFIPNAWQQELLD-----VVDKNESAVIVAPTSSGKTYASYYCMEKVLRESDVGVVVYVAPAKSLVGQvaatVENRFTKT 815
Cdd:pfam04851 1 KLELRPYQIEAIEnllesIKNGQKRGLIVMATGSGKTLTAAKLIARLFKKGPIKKVLFLVPRKDLLEQ----ALEEFKKF 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217352639 816 LPAGRTLCGAFT-RDYCHNVLNCQVLITVPECFEILLLAPHRQKWVERIRYVIFDEVHYLgrevGAKFWELLLVIIRCPF 894
Cdd:pfam04851 77 LPNYVEIGEIISgDKKDESVDDNKIVVTTIQSLYKALELASLELLPDFFDVIIIDEAHRS----GASSYRNILEYFKPAF 152
|
....*....
gi 2217352639 895 LV-LSATIN 902
Cdd:pfam04851 153 LLgLTATPE 161
|
|
| DEXHc_archSki2 |
cd18028 |
DEXH-box helicase domain of archaeal Ski2-type helicase; Archaeal Ski2-type RNA helicases play ... |
748-911 |
1.08e-11 |
|
DEXH-box helicase domain of archaeal Ski2-type helicase; Archaeal Ski2-type RNA helicases play an important role in RNA degradation, processing and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350786 [Multi-domain] Cd Length: 177 Bit Score: 65.05 E-value: 1.08e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217352639 748 QQELLD-VVDKNESAVIVAPTSSGKTYASYYCMEKVLRESdvGVVVYVAPAKSLVGQVAatveNRFTKTLPAGRTlCGAF 826
Cdd:cd18028 6 QAEAVRaGLLKGENLLISIPTASGKTLIAEMAMVNTLLEG--GKALYLVPLRALASEKY----EEFKKLEEIGLK-VGIS 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217352639 827 TRDY---CHNVLNCQVLITVPECFEILLlaPHRQKWVERIRYVIFDEVHYLGREVGAKFWELLLVIIR-----CPFLVLS 898
Cdd:cd18028 79 TGDYdedDEWLGDYDIIVATYEKFDSLL--RHSPSWLRDVGVVVVDEIHLISDEERGPTLESIVARLRrlnpnTQIIGLS 156
|
170
....*....|...
gi 2217352639 899 ATINNPNLLTKWL 911
Cdd:cd18028 157 ATIGNPDELAEWL 169
|
|
| DEXHc_SKIV2L |
cd18027 |
DEXH-box helicase domain of SKIV2L; Superkiller viralicidic activity 2-like (SKIV2L, also ... |
742-916 |
1.69e-10 |
|
DEXH-box helicase domain of SKIV2L; Superkiller viralicidic activity 2-like (SKIV2L, also called SKI2 or DHX13) plays a role in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. SKIV2L belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350785 [Multi-domain] Cd Length: 179 Bit Score: 61.90 E-value: 1.69e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217352639 742 FIPNAWQQELLDVVDKNESAVIVAPTSSGKTYASYYCMekVLRESDVGVVVYVAPAKSLVGQVAATVENRFTKTlpagrt 821
Cdd:cd18027 7 FELDVFQKQAILHLEAGDSVFVAAHTSAGKTVVAEYAI--ALAQKHMTRTIYTSPIKALSNQKFRDFKNTFGDV------ 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217352639 822 lcGAFTRDY-CHNVLNCQVLITvpecfEILLLAPHRQKWVER-IRYVIFDEVHYLGREVGAKFWELLLVII--RCPFLVL 897
Cdd:cd18027 79 --GLITGDVqLNPEASCLIMTT-----EILRSMLYNGSDVIRdLEWVIFDEVHYINDAERGVVWEEVLIMLpdHVSIILL 151
|
170
....*....|....*....
gi 2217352639 898 SATINNPNLLTKWLQSVKQ 916
Cdd:cd18027 152 SATVPNTVEFADWIGRIKK 170
|
|
| SF2-N |
cd00046 |
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ... |
758-900 |
7.87e-10 |
|
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.
Pssm-ID: 350668 [Multi-domain] Cd Length: 146 Bit Score: 58.95 E-value: 7.87e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217352639 758 NESAVIVAPTSSGKTYASYYCMEKVLRESDVGVVvYVAPAKSLVGQVAATVENRFTKTLPagrtlCGAFTRDY--CHNVL 835
Cdd:cd00046 1 GENVLITAPTGSGKTLAALLAALLLLLKKGKKVL-VLVPTKALALQTAERLRELFGPGIR-----VAVLVGGSsaEEREK 74
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2217352639 836 NC----QVLITVPECFEILLLaPHRQKWVERIRYVIFDEVH-YLGREVGAkfWELLLVIIR-----CPFLVLSAT 900
Cdd:cd00046 75 NKlgdaDIIIATPDMLLNLLL-REDRLFLKDLKLIIVDEAHaLLIDSRGA--LILDLAVRKaglknAQVILLSAT 146
|
|
| PRK00254 |
PRK00254 |
ski2-like helicase; Provisional |
757-919 |
1.91e-09 |
|
ski2-like helicase; Provisional
Pssm-ID: 234702 [Multi-domain] Cd Length: 720 Bit Score: 62.53 E-value: 1.91e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217352639 757 KNESAVIVAPTSSGKTYASYYCM-EKVLRESdvGVVVYVAPAKSLVGQ--------------VAATVENRFTKTLPAGRT 821
Cdd:PRK00254 38 EGKNLVLAIPTASGKTLVAEIVMvNKLLREG--GKAVYLVPLKALAEEkyrefkdweklglrVAMTTGDYDSTDEWLGKY 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217352639 822 lcgaftrdychnvlncQVLITVPECFEILLlaPHRQKWVERIRYVIFDEVHYLG-REVGAKFwELLL--VIIRCPFLVLS 898
Cdd:PRK00254 116 ----------------DIIIATAEKFDSLL--RHGSSWIKDVKLVVADEIHLIGsYDRGATL-EMILthMLGRAQILGLS 176
|
170 180
....*....|....*....|...
gi 2217352639 899 ATINNPNLLTKWLQS--VKQYWK 919
Cdd:PRK00254 177 ATVGNAEELAEWLNAelVVSDWR 199
|
|
| DEXHc_RE |
cd17926 |
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family ... |
747-900 |
5.66e-09 |
|
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family is composed of helicase restriction enzymes and similar proteins such as TFIIH basal transcription factor complex helicase XPB subunit. These proteins are part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350684 [Multi-domain] Cd Length: 146 Bit Score: 56.55 E-value: 5.66e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217352639 747 WQQELLDVVDKNES---AVIVAPTSSGKTYASYYCMEKVLRESdvgvVVYVAPAKSLVGQVAAtvenRFTKTLPaGRTLc 823
Cdd:cd17926 4 YQEEALEAWLAHKNnrrGILVLPTGSGKTLTALALIAYLKELR----TLIVVPTDALLDQWKE----RFEDFLG-DSSI- 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217352639 824 GAFTRDYCHNVLNCQVLITVPECFEILL---LAPHRQKWverirYVIFDEVHYLgrevGAKFWELLLVIIRCPFLV-LSA 899
Cdd:cd17926 74 GLIGGGKKKDFDDANVVVATYQSLSNLAeeeKDLFDQFG-----LLIVDEAHHL----PAKTFSEILKELNAKYRLgLTA 144
|
.
gi 2217352639 900 T 900
Cdd:cd17926 145 T 145
|
|
| DEXHc_Brr2_1 |
cd18019 |
N-terminal DEXH-box helicase domain of spliceosomal Brr2 RNA helicase; Brr2 is a type II DEAD ... |
756-903 |
6.28e-08 |
|
N-terminal DEXH-box helicase domain of spliceosomal Brr2 RNA helicase; Brr2 is a type II DEAD box helicase that mediates spliceosome catalytic activation. It is a stable subunit of the spliceosome, required during splicing catalysis and spliceosome disassembly. Brr2 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350777 [Multi-domain] Cd Length: 214 Bit Score: 55.07 E-value: 6.28e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217352639 756 DKNESAVIVAPTSSGKTYASYYCMEKVL---RESDVGV------VVYVAPAKSLVGQVAATVENRFTktlPAG---RTLC 823
Cdd:cd18019 31 ETDENLLLCAPTGAGKTNVALLTILREIgkhRNPDGTInldafkIVYIAPMKALVQEMVGNFSKRLA---PYGitvAELT 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217352639 824 G--AFTRDYCHNVlncQVLITVPECFEILLLAPHRQKWVERIRYVIFDEVHYLGREVGAKFWELLLVIIR--------CP 893
Cdd:cd18019 108 GdqQLTKEQISET---QIIVTTPEKWDIITRKSGDRTYTQLVRLIIIDEIHLLHDDRGPVLESIVARTIRqieqtqeyVR 184
|
170
....*....|
gi 2217352639 894 FLVLSATINN 903
Cdd:cd18019 185 LVGLSATLPN 194
|
|
| Lhr |
COG1201 |
Lhr-like helicase [Replication, recombination and repair]; |
744-911 |
1.54e-07 |
|
Lhr-like helicase [Replication, recombination and repair];
Pssm-ID: 440814 [Multi-domain] Cd Length: 850 Bit Score: 56.26 E-value: 1.54e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217352639 744 PNAWQQELLDVVDKNESAVIVAPTSSGKTYASYY-CMEKVLRESDVGV------VVYVAPAKSL--------------VG 802
Cdd:COG1201 25 PTPPQREAWPAIAAGESTLLIAPTGSGKTLAAFLpALDELARRPRPGElpdglrVLYISPLKALandiernlrapleeIG 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217352639 803 QVAA------TVENRFTKTLPAGRTlcgAFTRDYCHnvlncqVLITVPECFEILLLAPHRQKWVERIRYVIFDEVHYLgr 876
Cdd:COG1201 105 EAAGlplpeiRVGVRTGDTPASERQ---RQRRRPPH------ILITTPESLALLLTSPDARELLRGVRTVIVDEIHAL-- 173
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 2217352639 877 eVGAK---FWELLL----VIIRCPFLV--LSATINNPNLLTKWL 911
Cdd:COG1201 174 -AGSKrgvHLALSLerlrALAPRPLQRigLSATVGPLEEVARFL 216
|
|
| DEXHc_Brr2_2 |
cd18021 |
C-terminal D[D/E]X[H/Q]-box helicase domain of spliceosomal Brr2 RNA helicase; Brr2 is a type ... |
745-880 |
1.58e-07 |
|
C-terminal D[D/E]X[H/Q]-box helicase domain of spliceosomal Brr2 RNA helicase; Brr2 is a type II DEAD box helicase that mediates spliceosome catalytic activation. It is a stable subunit of the spliceosome, required during splicing catalysis and spliceosome disassembly. Brr2 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350779 [Multi-domain] Cd Length: 191 Bit Score: 53.42 E-value: 1.58e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217352639 745 NAWQQELLDVV-DKNESAVIVAPTSSGKTYASYYCMEKVLRESDVGVVVYVAPAKSLVGQVAATVENRFTKTLpaGRT-- 821
Cdd:cd18021 5 NPIQTQVFNSLyNTDDNVFVGAPTGSGKTVCAELALLRHWRQNPKGRAVYIAPMQELVDARYKDWRAKFGPLL--GKKvv 82
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217352639 822 -LCGAFTRDYCHnVLNCQVLITVPECFEILLLAPHRQKWVERIRYVIFDEVHYLGREVGA 880
Cdd:cd18021 83 kLTGETSTDLKL-LAKSDVILATPEQWDVLSRRWKQRKNVQSVELFIADELHLIGGENGP 141
|
|
| DEXHc_Hrq1-like |
cd17923 |
DEAH-box helicase domain of Hrq1 and similar proteins; Yeast Hrq1, similar to RecQ4, plays a ... |
759-904 |
2.69e-07 |
|
DEAH-box helicase domain of Hrq1 and similar proteins; Yeast Hrq1, similar to RecQ4, plays a role in DNA inter-strand crosslink (ICL) repair and in telomere maintenance. Hrq1 lacks the Sld2-like domain found in RecQ4. Hrq1 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350681 [Multi-domain] Cd Length: 182 Bit Score: 52.59 E-value: 2.69e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217352639 759 ESAVIVAPTSSGKTYAsyY---CMEKVLRESDVgVVVYVAPAKSLvgqvAATVENRFTKTLPA--GRTLCGAFTRDYCHN 833
Cdd:cd17923 16 RSVVVTTGTASGKSLC--YqlpILEALLRDPGS-RALYLYPTKAL----AQDQLRSLRELLEQlgLGIRVATYDGDTPRE 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217352639 834 V------LNCQVLITVPECFEILLLAPHRQ--KWVERIRYVIFDEVHY----LGREVGAKFWELL---------LVIIRC 892
Cdd:cd17923 89 ErraiirNPPRILLTNPDMLHYALLPHHDRwaRFLRNLRYVVLDEAHTyrgvFGSHVALLLRRLRrlcrrygadPQFILT 168
|
170
....*....|..
gi 2217352639 893 pflvlSATINNP 904
Cdd:cd17923 169 -----SATIGNP 175
|
|
| DEXHc_RLR |
cd18036 |
DEXH-box helicase domain of RIG-I-like receptors; RIG-I-like receptors (RLRs) sense ... |
742-877 |
3.47e-06 |
|
DEXH-box helicase domain of RIG-I-like receptors; RIG-I-like receptors (RLRs) sense cytoplasmic viral RNA and comprise RIG-I, RLR-2/MDA5 (melanoma differentiation-associated protein 5) and RLR-3/LGP2 (laboratory of genetics and physiology 2). RIG-I-like receptors (RLRs) are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350794 [Multi-domain] Cd Length: 204 Bit Score: 49.78 E-value: 3.47e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217352639 742 FIPNAWQQELLDVVDKNESAVIVAPTSSGKTYASYYCMEKVLRE----SDVGVVVYVAPAKSLVGQvAATVENRFTKTLP 817
Cdd:cd18036 1 LELRNYQLELVLPALRGKNTIICAPTGSGKTRVAVYICRHHLEKrrsaGEKGRVVVLVNKVPLVEQ-QLEKFFKYFRKGY 79
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2217352639 818 AGRTLCGAfTRDYC---HNVLNCQVLITVPECFEILLLAPHRQKWVERIRY--VIFDEVHYLGRE 877
Cdd:cd18036 80 KVTGLSGD-SSHKVsfgQIVKASDVIICTPQILINNLLSGREEERVYLSDFslLIFDECHHTQKE 143
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
1191-1263 |
7.28e-06 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 45.67 E-value: 7.28e-06
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2217352639 1191 NLKILEISEDCTYADVKALHTEITRNKDSVVTATETLALGIHMPCKSVVFaQDSVYLDALNYRQMSGRAGRRG 1263
Cdd:smart00490 11 GIKVARLHGGLSQEEREEILDKFNNGKIKVLVATDVAERGLDLPGVDLVI-IYDLPWSPASYIQRIGRAGRAG 82
|
|
| DEXHc_RIG-I |
cd17927 |
DEXH-box helicase domain of DEAD-like helicase RIG-I family proteins; Members of the RIG-I ... |
744-872 |
2.59e-05 |
|
DEXH-box helicase domain of DEAD-like helicase RIG-I family proteins; Members of the RIG-I family include FANCM, dicer, Hef, and the RIG-I-like receptors. Fanconi anemia group M (FANCM) protein is a DNA-dependent ATPase component of the Fanconi anemia (FA) core complex required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. Dicer ribonucleases cleave double-stranded RNA (dsRNA) precursors to generate microRNAs (miRNAs) and small interfering RNAs (siRNAs). Hef (helicase-associated endonuclease fork-structure) is involved in stalled replication fork repair. RIG-I-like receptors (RLRs) sense cytoplasmic viral RNA and comprises RIG-I, RLR-2/MDA5 (melanoma differentiation-associated protein 5) and RLR-3/LGP2 (laboratory of genetics and physiology 2). The RIG-I family is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350685 [Multi-domain] Cd Length: 201 Bit Score: 47.04 E-value: 2.59e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217352639 744 PNAWQQELLDVVDKNESAVIVAPTSSGKTYASYYCMEKVL---RESDVGVVVYVAPAKSLVGQVAATVENRFTKtlPAGR 820
Cdd:cd17927 3 PRNYQLELAQPALKGKNTIICLPTGSGKTFVAVLICEHHLkkfPAGRKGKVVFLANKVPLVEQQKEVFRKHFER--PGYK 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 2217352639 821 TlcGAFTRDYCHNVLN------CQVLITVPECFEILLLApHRQKWVERIRYVIFDEVH 872
Cdd:cd17927 81 V--TGLSGDTSENVSVeqivesSDVIIVTPQILVNDLKS-GTIVSLSDFSLLVFDECH 135
|
|
| DEXHc_Hef |
cd18035 |
DEXH-box helicase domain of Hef; Hef (helicase-associated endonuclease fork-structure) belongs ... |
748-872 |
5.74e-05 |
|
DEXH-box helicase domain of Hef; Hef (helicase-associated endonuclease fork-structure) belongs to the XPF/MUS81/FANCM family of endonucleases and is involved in stalled replication fork repair. All archaea encode a protein of the XPF/MUS81/FANCM family of endonucleases. It exists in two forms: a long form, referred as Hef which consists of an N-terminal helicase fused to a C-terminal nuclease and is specific to euryarchaea and a short form, referred as XPF which lacks the helicase domain and is specific to crenarchaea and thaumarchaea. Hef has the unique feature of having both active helicase and nuclease domains. This domain configuration is highly similar with the human FANCM, a possible ortholog of archaeal Hef proteins. Hef is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350793 [Multi-domain] Cd Length: 181 Bit Score: 45.58 E-value: 5.74e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217352639 748 QQELLDVVDKNESAVIVAPTSSGKTYASYYCMEKVLRESDvGVVVYVAPAKSLVGQVAATVENRFTKTLPAGrTLCGAFT 827
Cdd:cd18035 6 YQVLIAAVALNGNTLIVLPTGLGKTIIAILVAADRLTKKG-GKVLILAPSRPLVEQHAENLKRVLNIPDKIT-SLTGEVK 83
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 2217352639 828 RDYCHNVLN-CQVLITVPECFEILLLAPHRQkwVERIRYVIFDEVH 872
Cdd:cd18035 84 PEERAERWDaSKIIVATPQVIENDLLAGRIT--LDDVSLLIFDEAH 127
|
|
| Cas3 |
COG1203 |
CRISPR-Cas type I system-associated endonuclease/helicase Cas3 [Defense mechanisms]; ... |
745-900 |
8.09e-05 |
|
CRISPR-Cas type I system-associated endonuclease/helicase Cas3 [Defense mechanisms]; CRISPR-Cas type I system-associated endonuclease/helicase Cas3 is part of the Pathway/BioSystem: CRISPR-Cas system
Pssm-ID: 440816 [Multi-domain] Cd Length: 535 Bit Score: 47.38 E-value: 8.09e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217352639 745 NAWQQELLDVVDKNESA-----VIVAPTSSGKTYASYYCMEKVLRESDVGVVVYVAPAKSLVGQVAATVENRFT------ 813
Cdd:COG1203 129 NPLQNEALELALEAAEEepglfILTAPTGGGKTEAALLFALRLAAKHGGRRIIYALPFTSIINQTYDRLRDLFGedvllh 208
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217352639 814 --KTLPAGRTLCGAFTRDYCHNVLNCQVL---ITVpeC-----FEILLLA-PHRQKWVERIRY--VIFDEVHYLgrevGA 880
Cdd:COG1203 209 hsLADLDLLEEEEEYESEARWLKLLKELWdapVVV--TtidqlFESLFSNrKGQERRLHNLANsvIILDEVQAY----PP 282
|
170 180
....*....|....*....|....*.
gi 2217352639 881 KFWELLLVIIR------CPFLVLSAT 900
Cdd:COG1203 283 YMLALLLRLLEwlknlgGSVILMTAT 308
|
|
| DEXHc_ASCC3_1 |
cd18020 |
N-terminal DEXH-box helicase domain of Activating signal cointegrator 1 complex subunit 3; ... |
745-880 |
1.16e-04 |
|
N-terminal DEXH-box helicase domain of Activating signal cointegrator 1 complex subunit 3; Activating signal cointegrator 1 complex subunit 3 (ASCC3) is a type II DEAD box helicase that plays a role in the repair of N-alkylated nucleotides. ASCC3 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350778 [Multi-domain] Cd Length: 199 Bit Score: 45.11 E-value: 1.16e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217352639 745 NAWQQELLDVVDK-NESAVIVAPTSSGKTYASYYCMEKVLRES---------DVGVVVYVAPAKSLvgqvAATVENRFTK 814
Cdd:cd18020 3 NRIQSLVFPVAYKtNENMLICAPTGAGKTNIAMLTILHEIRQHvnqggvikkDDFKIVYIAPMKAL----AAEMVEKFSK 78
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2217352639 815 TL-PAG---RTLCG--AFTRDychNVLNCQVLITVPECFEILLL-APHRQKWVERIRYVIFDEVHYLGREVGA 880
Cdd:cd18020 79 RLaPLGikvKELTGdmQLTKK---EIAETQIIVTTPEKWDVVTRkSSGDVALSQLVRLLIIDEVHLLHDDRGP 148
|
|
| PRK13767 |
PRK13767 |
ATP-dependent helicase; Provisional |
755-874 |
3.39e-04 |
|
ATP-dependent helicase; Provisional
Pssm-ID: 237497 [Multi-domain] Cd Length: 876 Bit Score: 45.65 E-value: 3.39e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217352639 755 VDKNESAVIVAPTSSGKTYASY---------YCMEKVLRESdvgV-VVYVAPAKSL-----------VGQVAATVEN--- 810
Cdd:PRK13767 44 IHEGKNVLISSPTGSGKTLAAFlaiidelfrLGREGELEDK---VyCLYVSPLRALnndihrnleepLTEIREIAKErge 120
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2217352639 811 ---------RFTKTLPAGRTlcgAFTRDYCHnvlncqVLITVPECFEILLLAPH-RQKwVERIRYVIFDEVHYL 874
Cdd:PRK13767 121 elpeirvaiRTGDTSSYEKQ---KMLKKPPH------ILITTPESLAILLNSPKfREK-LRTVKWVIVDEIHSL 184
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
1183-1263 |
5.65e-04 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 41.04 E-value: 5.65e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217352639 1183 AEYINFLENLKILEISEDCTYADVKALHTEITRNKDSVVTATETLALGIHMPCKSVVFAQDSVYlDALNYRQMSGRAGRR 1262
Cdd:pfam00271 30 AELLLEKEGIKVARLHGDLSQEEREEILEDFRKGKIDVLVATDVAERGLDLPDVDLVINYDLPW-NPASYIQRIGRAGRA 108
|
.
gi 2217352639 1263 G 1263
Cdd:pfam00271 109 G 109
|
|
| PRK02362 |
PRK02362 |
ATP-dependent DNA helicase; |
1220-1265 |
1.56e-03 |
|
ATP-dependent DNA helicase;
Pssm-ID: 235032 [Multi-domain] Cd Length: 737 Bit Score: 43.41 E-value: 1.56e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 2217352639 1220 VVTATETLALGIHMPCKSVV------FAQDS--VYLDALNYRQMSGRAGRRGQD 1265
Cdd:PRK02362 332 VISSTPTLAAGLNLPARRVIirdyrrYDGGAgmQPIPVLEYHQMAGRAGRPGLD 385
|
|
|