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Conserved domains on  [gi|2217266012|ref|XP_047272535|]
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centromere protein R isoform X7 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CENP-R super family cl05996
Kinetochore component, CENP-R; This family consists of mammalian kinetochore sub-complex ...
 1-122 1.39e-60

Kinetochore component, CENP-R; This family consists of mammalian kinetochore sub-complex proteins CENP-R, also referred to as nuclear receptor co-activator NRIF3 proteins. NRIF3 exhibits a distinct receptor specificity in interacting with and potentiating the activity of only TRs and RXRs but not other examined nuclear receptors. NRIF3 as a co-regulator that possesses both transactivation and transrepression domains and/or functions. Collectively, the NRIF3 family of co-regulators may play dual roles in mediating both positive and negative regulatory effects on gene expression. CENP-R is one of the 15 components that make up the constitutive centromere associated complex (CCAN) part of the kinetochore. A sub-complex of CCAN, consisting of CENP-P/O/R/Q/U self-assembles on kinetochores with varying stoichiometry and undergoes a pre-mitotic maturation step. Kinetochore assembly is a cell cycle regulated multi-step process. The initial step occurs during interphase and involves loading of the 15-subunit constitutive centromere associated complex (CCAN). Kinetochores are multi-protein megadalton assemblies that are required for attachment of microtubules to centromeres and, in turn, the segregation of chromosomes in mitosis.


The actual alignment was detected with superfamily member pfam06729:

Pssm-ID: 429086  Cd Length: 138  Bit Score: 182.68  E-value: 1.39e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217266012   1 MSLFASPTSSEEQKHRNGLSNEKRKKLNHPSLTESKESTTKDnDEFMMLLSKVEKLSEEIMEIMQNLSSIQALEGSRELE 80
Cdd:pfam06729  17 MSPFSSPTSSKEQEHRNGPSNGKRKKLNHLSLSRRGQSTTKD-DEFMVLLSKVEKSLEEIMEIMQNLSSLQALEGSRELE 95

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 2217266012  81 NLIGISCASHFLKREMQKTKELMTKVNKQKLFEK-STGLPHKD 122
Cdd:pfam06729  96 NLIGVSCTSCFLKREMQKTKELMTKAEKQKLLEKkSSGLPAKE 138
 
Name Accession Description Interval E-value
CENP-R pfam06729
Kinetochore component, CENP-R; This family consists of mammalian kinetochore sub-complex ...
 1-122 1.39e-60

Kinetochore component, CENP-R; This family consists of mammalian kinetochore sub-complex proteins CENP-R, also referred to as nuclear receptor co-activator NRIF3 proteins. NRIF3 exhibits a distinct receptor specificity in interacting with and potentiating the activity of only TRs and RXRs but not other examined nuclear receptors. NRIF3 as a co-regulator that possesses both transactivation and transrepression domains and/or functions. Collectively, the NRIF3 family of co-regulators may play dual roles in mediating both positive and negative regulatory effects on gene expression. CENP-R is one of the 15 components that make up the constitutive centromere associated complex (CCAN) part of the kinetochore. A sub-complex of CCAN, consisting of CENP-P/O/R/Q/U self-assembles on kinetochores with varying stoichiometry and undergoes a pre-mitotic maturation step. Kinetochore assembly is a cell cycle regulated multi-step process. The initial step occurs during interphase and involves loading of the 15-subunit constitutive centromere associated complex (CCAN). Kinetochores are multi-protein megadalton assemblies that are required for attachment of microtubules to centromeres and, in turn, the segregation of chromosomes in mitosis.


Pssm-ID: 429086  Cd Length: 138  Bit Score: 182.68  E-value: 1.39e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217266012   1 MSLFASPTSSEEQKHRNGLSNEKRKKLNHPSLTESKESTTKDnDEFMMLLSKVEKLSEEIMEIMQNLSSIQALEGSRELE 80
Cdd:pfam06729  17 MSPFSSPTSSKEQEHRNGPSNGKRKKLNHLSLSRRGQSTTKD-DEFMVLLSKVEKSLEEIMEIMQNLSSLQALEGSRELE 95

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 2217266012  81 NLIGISCASHFLKREMQKTKELMTKVNKQKLFEK-STGLPHKD 122
Cdd:pfam06729  96 NLIGVSCTSCFLKREMQKTKELMTKAEKQKLLEKkSSGLPAKE 138
 
Name Accession Description Interval E-value
CENP-R pfam06729
Kinetochore component, CENP-R; This family consists of mammalian kinetochore sub-complex ...
 1-122 1.39e-60

Kinetochore component, CENP-R; This family consists of mammalian kinetochore sub-complex proteins CENP-R, also referred to as nuclear receptor co-activator NRIF3 proteins. NRIF3 exhibits a distinct receptor specificity in interacting with and potentiating the activity of only TRs and RXRs but not other examined nuclear receptors. NRIF3 as a co-regulator that possesses both transactivation and transrepression domains and/or functions. Collectively, the NRIF3 family of co-regulators may play dual roles in mediating both positive and negative regulatory effects on gene expression. CENP-R is one of the 15 components that make up the constitutive centromere associated complex (CCAN) part of the kinetochore. A sub-complex of CCAN, consisting of CENP-P/O/R/Q/U self-assembles on kinetochores with varying stoichiometry and undergoes a pre-mitotic maturation step. Kinetochore assembly is a cell cycle regulated multi-step process. The initial step occurs during interphase and involves loading of the 15-subunit constitutive centromere associated complex (CCAN). Kinetochores are multi-protein megadalton assemblies that are required for attachment of microtubules to centromeres and, in turn, the segregation of chromosomes in mitosis.


Pssm-ID: 429086  Cd Length: 138  Bit Score: 182.68  E-value: 1.39e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217266012   1 MSLFASPTSSEEQKHRNGLSNEKRKKLNHPSLTESKESTTKDnDEFMMLLSKVEKLSEEIMEIMQNLSSIQALEGSRELE 80
Cdd:pfam06729  17 MSPFSSPTSSKEQEHRNGPSNGKRKKLNHLSLSRRGQSTTKD-DEFMVLLSKVEKSLEEIMEIMQNLSSLQALEGSRELE 95

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 2217266012  81 NLIGISCASHFLKREMQKTKELMTKVNKQKLFEK-STGLPHKD 122
Cdd:pfam06729  96 NLIGVSCTSCFLKREMQKTKELMTKAEKQKLLEKkSSGLPAKE 138
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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