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Conserved domains on  [gi|2217354453|ref|XP_047272685|]
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WD repeat-containing protein 36 isoform X1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
164-636 8.24e-36

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 140.05  E-value: 8.24e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217354453 164 ILLGSEQGSLQLWNVKSNKLLYTFPGWKVGVTALQQAPAVDVVAIGLMSGQVIIHNIKFNETLMKFRQDWGPITSISFRT 243
Cdd:COG2319     9 LAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSP 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217354453 244 DGHPVmAAGSPCGHIGLWDLEDKKLINQMRnAHSTAIAGLTFLHREPLLVTNGADNALRIWifdgPTGEGRLLRFRMGHS 323
Cdd:COG2319    89 DGRLL-ASASADGTVRLWDLATGLLLRTLT-GHTGAVRSVAFSPDGKTLASGSADGTVRLW----DLATGKLLRTLTGHS 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217354453 324 APLTNIRYyGQNGQQILSASQDGTlqsfstvhekfnkslghglinkkrvkrkglqntmsVRLppitkfaaeearesdWDg 403
Cdd:COG2319   163 GAVTSVAF-SPDGKLLASGSDDGT-----------------------------------VRL---------------WD- 190

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217354453 404 iiaCHQGKLscstwnyqkstigayflkPKELKKDDITATAVDITSCGNFAVIGLSSGTVDVYNMQSGIHRGSFgkdQAHK 483
Cdd:COG2319   191 ---LATGKL------------------LRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTL---TGHS 246

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217354453 484 GSVRGVAV--DGlnQLTVTTGSEGLLKFWNFKNKILIHSVS-LSSSPNIMLLHRDSGILGLALDDFSISVLDIETRKIVR 560
Cdd:COG2319   247 GSVRSVAFspDG--RLLASGSADGTVRLWDLATGELLRTLTgHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLR 324

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2217354453 561 EFSGHQGQINDMAFSPDGRWLISAAMDCSIRTWDLPSGCLIDCFLLDSAPLN-VSMSPTGDFLATSHVDHlGIYLWS 636
Cdd:COG2319   325 TLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTsVAFSPDGRTLASGSADG-TVRLWD 400
Utp21 super family cl04442
Utp21 specific WD40 associated putative domain; Utp21 is a subunit of U3 snoRNP, which is ...
 689-756 5.08e-16

Utp21 specific WD40 associated putative domain; Utp21 is a subunit of U3 snoRNP, which is essential for synthesis of 18S rRNA.


The actual alignment was detected with superfamily member pfam04192:

Pssm-ID: 461219  Cd Length: 209  Bit Score: 77.57  E-value: 5.08e-16
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2217354453 689 EQLNEQLVTLSLLPESRWKNLLNLDVIKKKNKPKEPPKVPKSAPFFIPTIPGLVPRYAAPEQNNDPQQ 756
Cdd:pfam04192   1 DQLSEDLVTLSLLPRSRWQTLLHLDLIKQRNKPKEAPKKPEKAPFFLPTLGGLVGDFASVEAQEEEEE 68
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 93-217 1.66e-07

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 53.49  E-value: 1.66e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217354453  93 ARNKEIVHTFKGHKAEIHFLQPFGD--HIISVDTDGILIIWHIYSEEEYLQLT-FDKSVFkiSAILHPSTYLnkILLGSE 169
Cdd:cd00200   164 LRTGKCVATLTGHTGEVNSVAFSPDgeKLLSSSSDGTIKLWDLSTGKCLGTLRgHENGVN--SVAFSPDGYL--LASGSE 239

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 2217354453 170 QGSLQLWNVKSNKLLYTFPGWKVGVTALQQAPAVDVVAIGLMSGQVII 217
Cdd:cd00200   240 DGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRI 287
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
164-636 8.24e-36

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 140.05  E-value: 8.24e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217354453 164 ILLGSEQGSLQLWNVKSNKLLYTFPGWKVGVTALQQAPAVDVVAIGLMSGQVIIHNIKFNETLMKFRQDWGPITSISFRT 243
Cdd:COG2319     9 LAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSP 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217354453 244 DGHPVmAAGSPCGHIGLWDLEDKKLINQMRnAHSTAIAGLTFLHREPLLVTNGADNALRIWifdgPTGEGRLLRFRMGHS 323
Cdd:COG2319    89 DGRLL-ASASADGTVRLWDLATGLLLRTLT-GHTGAVRSVAFSPDGKTLASGSADGTVRLW----DLATGKLLRTLTGHS 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217354453 324 APLTNIRYyGQNGQQILSASQDGTlqsfstvhekfnkslghglinkkrvkrkglqntmsVRLppitkfaaeearesdWDg 403
Cdd:COG2319   163 GAVTSVAF-SPDGKLLASGSDDGT-----------------------------------VRL---------------WD- 190

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217354453 404 iiaCHQGKLscstwnyqkstigayflkPKELKKDDITATAVDITSCGNFAVIGLSSGTVDVYNMQSGIHRGSFgkdQAHK 483
Cdd:COG2319   191 ---LATGKL------------------LRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTL---TGHS 246

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217354453 484 GSVRGVAV--DGlnQLTVTTGSEGLLKFWNFKNKILIHSVS-LSSSPNIMLLHRDSGILGLALDDFSISVLDIETRKIVR 560
Cdd:COG2319   247 GSVRSVAFspDG--RLLASGSADGTVRLWDLATGELLRTLTgHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLR 324

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2217354453 561 EFSGHQGQINDMAFSPDGRWLISAAMDCSIRTWDLPSGCLIDCFLLDSAPLN-VSMSPTGDFLATSHVDHlGIYLWS 636
Cdd:COG2319   325 TLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTsVAFSPDGRTLASGSADG-TVRLWD 400
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 276-594 3.67e-30

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 120.90  E-value: 3.67e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217354453 276 HSTAIAGLTFLHREPLLVTNGADNALRIWIFDGptgeGRLLRFRMGHSAPLTNIRYYGqNGQQILSASQDGTLQSFSTVH 355
Cdd:cd00200     8 HTGGVTCVAFSPDGKLLATGSGDGTIKVWDLET----GELLRTLKGHTGPVRDVAASA-DGTYLASGSSDKTIRLWDLET 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217354453 356 EKFNKSL-GHglinKKRVkrkglqntMSVRLPPITKFAAEeareSDWDGIIAChqgklscstWNyqksTIGAYFLKPKEL 434
Cdd:cd00200    83 GECVRTLtGH----TSYV--------SSVAFSPDGRILSS----SSRDKTIKV---------WD----VETGKCLTTLRG 133

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217354453 435 KKDDITAtaVDITSCGNFAVIGLSSGTVDVYNMQSGIHRGSFgkdQAHKGSVRGVAVDGLNQLTVTTGSEGLLKFWNFKN 514
Cdd:cd00200   134 HTDWVNS--VAFSPDGTFVASSSQDGTIKLWDLRTGKCVATL---TGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLST 208

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217354453 515 KILIHSvsLSSSPNI---MLLHRDSGILGLALDDFSISVLDIETRKIVREFSGHQGQINDMAFSPDGRWLISAAMDCSIR 591
Cdd:cd00200   209 GKCLGT--LRGHENGvnsVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIR 286


                  ...
gi 2217354453 592 TWD 594
Cdd:cd00200   287 IWD 289
Utp21 pfam04192
Utp21 specific WD40 associated putative domain; Utp21 is a subunit of U3 snoRNP, which is ...
 689-756 5.08e-16

Utp21 specific WD40 associated putative domain; Utp21 is a subunit of U3 snoRNP, which is essential for synthesis of 18S rRNA.


Pssm-ID: 461219  Cd Length: 209  Bit Score: 77.57  E-value: 5.08e-16
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2217354453 689 EQLNEQLVTLSLLPESRWKNLLNLDVIKKKNKPKEPPKVPKSAPFFIPTIPGLVPRYAAPEQNNDPQQ 756
Cdd:pfam04192   1 DQLSEDLVTLSLLPRSRWQTLLHLDLIKQRNKPKEAPKKPEKAPFFLPTLGGLVGDFASVEAQEEEEE 68
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 555-594 1.72e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 53.47  E-value: 1.72e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 2217354453  555 TRKIVREFSGHQGQINDMAFSPDGRWLISAAMDCSIRTWD 594
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
556-594 3.70e-09

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 52.73  E-value: 3.70e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 2217354453 556 RKIVREFSGHQGQINDMAFSPDGRWLISAAMDCSIRTWD 594
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 93-217 1.66e-07

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 53.49  E-value: 1.66e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217354453  93 ARNKEIVHTFKGHKAEIHFLQPFGD--HIISVDTDGILIIWHIYSEEEYLQLT-FDKSVFkiSAILHPSTYLnkILLGSE 169
Cdd:cd00200   164 LRTGKCVATLTGHTGEVNSVAFSPDgeKLLSSSSDGTIKLWDLSTGKCLGTLRgHENGVN--SVAFSPDGYL--LASGSE 239

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 2217354453 170 QGSLQLWNVKSNKLLYTFPGWKVGVTALQQAPAVDVVAIGLMSGQVII 217
Cdd:cd00200   240 DGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRI 287
PQQ_ABC_repeats TIGR03866
PQQ-dependent catabolism-associated beta-propeller protein; Members of this protein family ...
 517-625 5.69e-05

PQQ-dependent catabolism-associated beta-propeller protein; Members of this protein family consist of seven repeats each of the YVTN family beta-propeller repeat (see TIGR02276). Members occur invariably as part of a transport operon that is associated with PQQ-dependent catabolism of alcohols such as phenylethanol.


Pssm-ID: 274824 [Multi-domain]  Cd Length: 310  Bit Score: 45.80  E-value: 5.69e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217354453 517 LIHSVSLSSSPNIMLLHRDSGILGLA-LDDFSISVLDIETRKIVrefsghqGQIN------DMAFSPDGRWLISAAMDCS 589
Cdd:TIGR03866  75 VLHTLPSGPDPEQFALHPNGKILYIAnEDDALVTVIDIETRKVL-------AQIDvgvepeGMAVSPDGKIVVNTSETTN 147

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 2217354453 590 IRTW-DLPSGCLIDCFLLDSAPLNVSMSPTGDFLATS 625
Cdd:TIGR03866 148 MAHWiDTATYEIVDNTLVDARPRFAEFTADGKELWVS 184
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 95-132 5.17e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 35.37  E-value: 5.17e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 2217354453   95 NKEIVHTFKGHKAEIHFLQ--PFGDHIISVDTDGILIIWH 132
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAfsPDGKYLASGSDDGTIKLWD 40
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
164-636 8.24e-36

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 140.05  E-value: 8.24e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217354453 164 ILLGSEQGSLQLWNVKSNKLLYTFPGWKVGVTALQQAPAVDVVAIGLMSGQVIIHNIKFNETLMKFRQDWGPITSISFRT 243
Cdd:COG2319     9 LAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSP 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217354453 244 DGHPVmAAGSPCGHIGLWDLEDKKLINQMRnAHSTAIAGLTFLHREPLLVTNGADNALRIWifdgPTGEGRLLRFRMGHS 323
Cdd:COG2319    89 DGRLL-ASASADGTVRLWDLATGLLLRTLT-GHTGAVRSVAFSPDGKTLASGSADGTVRLW----DLATGKLLRTLTGHS 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217354453 324 APLTNIRYyGQNGQQILSASQDGTlqsfstvhekfnkslghglinkkrvkrkglqntmsVRLppitkfaaeearesdWDg 403
Cdd:COG2319   163 GAVTSVAF-SPDGKLLASGSDDGT-----------------------------------VRL---------------WD- 190

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217354453 404 iiaCHQGKLscstwnyqkstigayflkPKELKKDDITATAVDITSCGNFAVIGLSSGTVDVYNMQSGIHRGSFgkdQAHK 483
Cdd:COG2319   191 ---LATGKL------------------LRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTL---TGHS 246

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217354453 484 GSVRGVAV--DGlnQLTVTTGSEGLLKFWNFKNKILIHSVS-LSSSPNIMLLHRDSGILGLALDDFSISVLDIETRKIVR 560
Cdd:COG2319   247 GSVRSVAFspDG--RLLASGSADGTVRLWDLATGELLRTLTgHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLR 324

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2217354453 561 EFSGHQGQINDMAFSPDGRWLISAAMDCSIRTWDLPSGCLIDCFLLDSAPLN-VSMSPTGDFLATSHVDHlGIYLWS 636
Cdd:COG2319   325 TLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTsVAFSPDGRTLASGSADG-TVRLWD 400
WD40 COG2319
WD40 repeat [General function prediction only];
164-597 4.46e-35

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 138.12  E-value: 4.46e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217354453 164 ILLGSEQGSLQLWNVKSNKLLYTFPGWKVGVTALQQAPAVDVVAIGLMSGQVIIHNIKFNETLMKFRQDWGPITSISFRT 243
Cdd:COG2319    51 LAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSP 130

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217354453 244 DGHPVMAAGSPcGHIGLWDLEDKKLINQMRnAHSTAIAGLTFLHREPLLVTNGADNALRIWifDGPTGegRLLRFRMGHS 323
Cdd:COG2319   131 DGKTLASGSAD-GTVRLWDLATGKLLRTLT-GHSGAVTSVAFSPDGKLLASGSDDGTVRLW--DLATG--KLLRTLTGHT 204

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217354453 324 APLTNIRYyGQNGQQILSASQDGTlqsfstvhekfnkslghglinkkrvkrkglqntmsVRLppitkfaaeearesdWDg 403
Cdd:COG2319   205 GAVRSVAF-SPDGKLLASGSADGT-----------------------------------VRL---------------WD- 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217354453 404 iiaCHQGKLscstwnyqkstigayflkPKELKKDDITATAVDITSCGNFAVIGLSSGTVDVYNMQSGIHRGSFGkdqAHK 483
Cdd:COG2319   233 ---LATGKL------------------LRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLT---GHS 288

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217354453 484 GSVRGVAVDGLNQLTVTTGSEGLLKFWNFKNKILIHSVSLSSSPNIML-LHRDSGILGLALDDFSISVLDIETRKIVREF 562
Cdd:COG2319   289 GGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVaFSPDGKTLASGSDDGTVRLWDLATGELLRTL 368

                         410       420       430
                  ....*....|....*....|....*....|....*
gi 2217354453 563 SGHQGQINDMAFSPDGRWLISAAMDCSIRTWDLPS 597
Cdd:COG2319   369 TGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 276-594 3.67e-30

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 120.90  E-value: 3.67e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217354453 276 HSTAIAGLTFLHREPLLVTNGADNALRIWIFDGptgeGRLLRFRMGHSAPLTNIRYYGqNGQQILSASQDGTLQSFSTVH 355
Cdd:cd00200     8 HTGGVTCVAFSPDGKLLATGSGDGTIKVWDLET----GELLRTLKGHTGPVRDVAASA-DGTYLASGSSDKTIRLWDLET 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217354453 356 EKFNKSL-GHglinKKRVkrkglqntMSVRLPPITKFAAEeareSDWDGIIAChqgklscstWNyqksTIGAYFLKPKEL 434
Cdd:cd00200    83 GECVRTLtGH----TSYV--------SSVAFSPDGRILSS----SSRDKTIKV---------WD----VETGKCLTTLRG 133

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217354453 435 KKDDITAtaVDITSCGNFAVIGLSSGTVDVYNMQSGIHRGSFgkdQAHKGSVRGVAVDGLNQLTVTTGSEGLLKFWNFKN 514
Cdd:cd00200   134 HTDWVNS--VAFSPDGTFVASSSQDGTIKLWDLRTGKCVATL---TGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLST 208

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217354453 515 KILIHSvsLSSSPNI---MLLHRDSGILGLALDDFSISVLDIETRKIVREFSGHQGQINDMAFSPDGRWLISAAMDCSIR 591
Cdd:cd00200   209 GKCLGT--LRGHENGvnsVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIR 286


                  ...
gi 2217354453 592 TWD 594
Cdd:cd00200   287 IWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 99-364 9.47e-25

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 105.11  E-value: 9.47e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217354453  99 VHTFKGHKAEIHFLQ--PFGDHIISVDTDGILIIWHIYSEEEYLQLT-FDKSVFKISAILHpstyLNKILLGSEQGSLQL 175
Cdd:cd00200     2 RRTLKGHTGGVTCVAfsPDGKLLATGSGDGTIKVWDLETGELLRTLKgHTGPVRDVAASAD----GTYLASGSSDKTIRL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217354453 176 WNVKSNKLLYTFPGWKVGVTALQQAPAVDVVAIGLMSGQVIIHNIKFNETLMKFRQDWGPITSISFRTDGHpVMAAGSPC 255
Cdd:cd00200    78 WDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGT-FVASSSQD 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217354453 256 GHIGLWDLEDKKLINQMRnAHSTAIAGLTFLHREPLLVTNGADNALRIWIFDgptgEGRLLRFRMGHSAPLTNIRYyGQN 335
Cdd:cd00200   157 GTIKLWDLRTGKCVATLT-GHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLS----TGKCLGTLRGHENGVNSVAF-SPD 230

                         250       260       270
                  ....*....|....*....|....*....|
gi 2217354453 336 GQQILSASQDGTLQSFSTVHEKFNKSL-GH 364
Cdd:cd00200   231 GYLLASGSEDGTIRVWDLRTGECVQTLsGH 260
WD40 COG2319
WD40 repeat [General function prediction only];
93-349 3.96e-24

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 105.38  E-value: 3.96e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217354453  93 ARNKEIVHTFKGHKAEIHFLQ--PFGDHIISVDTDGILIIWHIYSEEEYLQLTFDKSVFKISAILHPSTYLnkiLLGSEQ 170
Cdd:COG2319   149 LATGKLLRTLTGHSGAVTSVAfsPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLL---ASGSAD 225

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217354453 171 GSLQLWNVKSNKLLYTFPGWKVGVTALQQAPAVDVVAIGLMSGQVIIHNIKFNETLMKFRQDWGPITSISFRTDGHPVMA 250
Cdd:COG2319   226 GTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLAS 305

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217354453 251 AGSPcGHIGLWDLEDKKLINQMRnAHSTAIAGLTFLHREPLLVTNGADNALRIWIFDGptgeGRLLRFRMGHSAPLTNIR 330
Cdd:COG2319   306 GSDD-GTVRLWDLATGKLLRTLT-GHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLAT----GELLRTLTGHTGAVTSVA 379

                         250
                  ....*....|....*....
gi 2217354453 331 YyGQNGQQILSASQDGTLQ 349
Cdd:COG2319   380 F-SPDGRTLASGSADGTVR 397
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 71-348 2.80e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 94.71  E-value: 2.80e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217354453  71 ICCMA--ADGRLVFAAYGN----VFSAFarNKEIVHTFKGHKAEIHFLQ--PFGDHIISVDTDGILIIWHIYSEEEYLQL 142
Cdd:cd00200    12 VTCVAfsPDGKLLATGSGDgtikVWDLE--TGELLRTLKGHTGPVRDVAasADGTYLASGSSDKTIRLWDLETGECVRTL 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217354453 143 T-FDKSVFKISaiLHPSTYLnkILLGSEQGSLQLWNVKSNKLLYTFPGWKVGVTALQQAPAVDVVAIGLMSGQVIIHNIK 221
Cdd:cd00200    90 TgHTSYVSSVA--FSPDGRI--LSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLR 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217354453 222 FNETLMKFRQDWGPITSISFRTDGHPVMAAGSPcGHIGLWDLEDKKLINQMRnAHSTAIAGLTFLHREPLLVTNGADNAL 301
Cdd:cd00200   166 TGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSD-GTIKLWDLSTGKCLGTLR-GHENGVNSVAFSPDGYLLASGSEDGTI 243

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 2217354453 302 RIWifDGPTGEgRLLRFRmGHSAPLTNIRYYGqNGQQILSASQDGTL 348
Cdd:cd00200   244 RVW--DLRTGE-CVQTLS-GHTNSVTSLAWSP-DGKRLASGSADGTI 285
WD40 COG2319
WD40 repeat [General function prediction only];
31-304 2.56e-20

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 94.21  E-value: 2.56e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217354453  31 VRFSALKRRFyVTTCVGKSFHTYDVQKLSLVAVSNSVPQDICCMA--ADGRLVFAAYGN----VFSAfaRNKEIVHTFKG 104
Cdd:COG2319   126 VAFSPDGKTL-ASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAfsPDGKLLASGSDDgtvrLWDL--ATGKLLRTLTG 202

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217354453 105 HKAEIHFLQ--PFGDHIISVDTDGILIIWHIYSEEeyLQLTFDKSVFKISAI-LHPStylNKILL-GSEQGSLQLWNVKS 180
Cdd:COG2319   203 HTGAVRSVAfsPDGKLLASGSADGTVRLWDLATGK--LLRTLTGHSGSVRSVaFSPD---GRLLAsGSADGTVRLWDLAT 277

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217354453 181 NKLLYTFPGWKVGVTALQQAPAVDVVAIGLMSGQVIIHNIKFNETLMKFRQDWGPITSISFRTDGHPVmAAGSPCGHIGL 260
Cdd:COG2319   278 GELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTL-ASGSDDGTVRL 356

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 2217354453 261 WDLEDKKLINQMRnAHSTAIAGLTFLHREPLLVTNGADNALRIW 304
Cdd:COG2319   357 WDLATGELLRTLT-GHTGAVTSVAFSPDGRTLASGSADGTVRLW 399
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 442-636 4.89e-20

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 91.24  E-value: 4.89e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217354453 442 TAVDITSCGNFAVIGLSSGTVDVYNMQSGIHRGSFgkdQAHKGSVRGVAVDGLNQLTVTTGSEGLLKFWNFKNKILIH-- 519
Cdd:cd00200    13 TCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTL---KGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRtl 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217354453 520 --------SVSLSSSPNIML---------------------------------LHRDSGILGLALDDFSISVLDIETRKI 558
Cdd:cd00200    90 tghtsyvsSVAFSPDGRILSsssrdktikvwdvetgkclttlrghtdwvnsvaFSPDGTFVASSSQDGTIKLWDLRTGKC 169

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2217354453 559 VREFSGHQGQINDMAFSPDGRWLISAAMDCSIRTWDLPSGCLIDCFLLDSAPLN-VSMSPTGDFLATSHVDHlGIYLWS 636
Cdd:cd00200   170 VATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNsVAFSPDGYLLASGSEDG-TIRVWD 247
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 480-636 6.79e-20

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 90.86  E-value: 6.79e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217354453 480 QAHKGSVRGVAVDGLNQLTVTTGSEGLLKFWNFKNKILI-----HSVSLSSSpnimLLHRDSGILGLALDDFSISVLDIE 554
Cdd:cd00200     6 KGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLrtlkgHTGPVRDV----AASADGTYLASGSSDKTIRLWDLE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217354453 555 TRKIVREFSGHQGQINDMAFSPDGRWLISAAMDCSIRTWDLPSGCLIDCFLLDSAPLN-VSMSPTGDFLATSHVDHLgIY 633
Cdd:cd00200    82 TGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNsVAFSPDGTFVASSSQDGT-IK 160


                  ...
gi 2217354453 634 LWS 636
Cdd:cd00200   161 LWD 163
Utp21 pfam04192
Utp21 specific WD40 associated putative domain; Utp21 is a subunit of U3 snoRNP, which is ...
 689-756 5.08e-16

Utp21 specific WD40 associated putative domain; Utp21 is a subunit of U3 snoRNP, which is essential for synthesis of 18S rRNA.


Pssm-ID: 461219  Cd Length: 209  Bit Score: 77.57  E-value: 5.08e-16
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2217354453 689 EQLNEQLVTLSLLPESRWKNLLNLDVIKKKNKPKEPPKVPKSAPFFIPTIPGLVPRYAAPEQNNDPQQ 756
Cdd:pfam04192   1 DQLSEDLVTLSLLPRSRWQTLLHLDLIKQRNKPKEAPKKPEKAPFFLPTLGGLVGDFASVEAQEEEEE 68
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 94-304 2.52e-14

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 74.29  E-value: 2.52e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217354453  94 RNKEIVHTFKGHKAEI---HFLQpfGDHIISVD-TDGILIIWHIysEEEYLQLTFD---KSVFKISaiLHPStylNKILL 166
Cdd:cd00200    81 ETGECVRTLTGHTSYVssvAFSP--DGRILSSSsRDKTIKVWDV--ETGKCLTTLRghtDWVNSVA--FSPD---GTFVA 151

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217354453 167 GSEQ-GSLQLWNVKSNKLLYTFPGWKVGVTALQQAPAVDVVAIGLMSGQVIIHNIKFNETLMKFRQDWGPITSISFRTDG 245
Cdd:cd00200   152 SSSQdGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDG 231

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2217354453 246 HpVMAAGSPCGHIGLWDLEDKKLINQMRnAHSTAIAGLTFLHREPLLVTNGADNALRIW 304
Cdd:cd00200   232 Y-LLASGSEDGTIRVWDLRTGECVQTLS-GHTNSVTSLAWSPDGKRLASGSADGTIRIW 288
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 559-636 8.95e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 60.43  E-value: 8.95e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2217354453 559 VREFSGHQGQINDMAFSPDGRWLISAAMDCSIRTWDLPSGCLIDCFLLDSAPLN-VSMSPTGDFLATSHVDHLgIYLWS 636
Cdd:cd00200     2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRdVAASADGTYLASGSSDKT-IRLWD 79
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 555-594 1.72e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 53.47  E-value: 1.72e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 2217354453  555 TRKIVREFSGHQGQINDMAFSPDGRWLISAAMDCSIRTWD 594
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
556-594 3.70e-09

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 52.73  E-value: 3.70e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 2217354453 556 RKIVREFSGHQGQINDMAFSPDGRWLISAAMDCSIRTWD 594
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
439-622 3.07e-08

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 55.09  E-value: 3.07e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217354453 439 ITATAVDITSCGNFAVIGLSSGTVDVYNMQSGIHRGSFGKDQAHKGSVRGVAVDGlNQLTVTTGSEGLLKFWNFKNKILI 518
Cdd:COG3391    25 VAALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADG-RRLYVANSGSGRVSVIDLATGKVV 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217354453 519 HSVSLSSSPNIMLLHRDSGILGLA-LDDFSISVLDIETRKIVREFSGHqGQINDMAFSPDGRWLISAAMDCS-----IRT 592
Cdd:COG3391   104 ATIPVGGGPRGLAVDPDGGRLYVAdSGNGRVSVIDTATGKVVATIPVG-AGPHGIAVDPDGKRLYVANSGSNtvsviVSV 182

                         170       180       190
                  ....*....|....*....|....*....|
gi 2217354453 593 WDLPSGCLIDCFLLDSAPLNVSMSPTGDFL 622
Cdd:COG3391   183 IDTATGKVVATIPVGGGPVGVAVSPDGRRL 212
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 93-217 1.66e-07

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 53.49  E-value: 1.66e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217354453  93 ARNKEIVHTFKGHKAEIHFLQPFGD--HIISVDTDGILIIWHIYSEEEYLQLT-FDKSVFkiSAILHPSTYLnkILLGSE 169
Cdd:cd00200   164 LRTGKCVATLTGHTGEVNSVAFSPDgeKLLSSSSDGTIKLWDLSTGKCLGTLRgHENGVN--SVAFSPDGYL--LASGSE 239

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 2217354453 170 QGSLQLWNVKSNKLLYTFPGWKVGVTALQQAPAVDVVAIGLMSGQVII 217
Cdd:cd00200   240 DGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRI 287
PQQ_ABC_repeats TIGR03866
PQQ-dependent catabolism-associated beta-propeller protein; Members of this protein family ...
 517-625 5.69e-05

PQQ-dependent catabolism-associated beta-propeller protein; Members of this protein family consist of seven repeats each of the YVTN family beta-propeller repeat (see TIGR02276). Members occur invariably as part of a transport operon that is associated with PQQ-dependent catabolism of alcohols such as phenylethanol.


Pssm-ID: 274824 [Multi-domain]  Cd Length: 310  Bit Score: 45.80  E-value: 5.69e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217354453 517 LIHSVSLSSSPNIMLLHRDSGILGLA-LDDFSISVLDIETRKIVrefsghqGQIN------DMAFSPDGRWLISAAMDCS 589
Cdd:TIGR03866  75 VLHTLPSGPDPEQFALHPNGKILYIAnEDDALVTVIDIETRKVL-------AQIDvgvepeGMAVSPDGKIVVNTSETTN 147

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 2217354453 590 IRTW-DLPSGCLIDCFLLDSAPLNVSMSPTGDFLATS 625
Cdd:TIGR03866 148 MAHWiDTATYEIVDNTLVDARPRFAEFTADGKELWVS 184
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 201-285 6.62e-04

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 39.18  E-value: 6.62e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217354453 201 PAVDVVAIGLMSGQVIIHNIKFNE--TLMKFRQDwGPITSISFRTDGHpVMAAGSPCGHIGLWDLEDKKLINQmRNAHST 278
Cdd:pfam12894   5 PTMDLIALATEDGELLLHRLNWQRvwTLSPDKED-LEVTSLAWRPDGK-LLAVGYSDGTVRLLDAENGKIVHH-FSAGSD 81


                  ....*..
gi 2217354453 279 AIAGLTF 285
Cdd:pfam12894  82 LITCLGW 88
COG4946 COG4946
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ...
 544-581 1.86e-03

Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];


Pssm-ID: 443973 [Multi-domain]  Cd Length: 1072  Bit Score: 41.95  E-value: 1.86e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 2217354453  544 DDFSISVLDIET---RKIVRefSGHQGQINDMAFSPDGRWL 581
Cdd:COG4946    408 NRGRLWVVDLASgkvRKVDT--DGYGDGISDLAWSPDSKWL 446
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 95-132 5.17e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 35.37  E-value: 5.17e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 2217354453   95 NKEIVHTFKGHKAEIHFLQ--PFGDHIISVDTDGILIIWH 132
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAfsPDGKYLASGSDDGTIKLWD 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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